CN201514402U - High-performance chromatograph for circulating liquid phase - Google Patents
High-performance chromatograph for circulating liquid phase Download PDFInfo
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- CN201514402U CN201514402U CN2009200942731U CN200920094273U CN201514402U CN 201514402 U CN201514402 U CN 201514402U CN 2009200942731 U CN2009200942731 U CN 2009200942731U CN 200920094273 U CN200920094273 U CN 200920094273U CN 201514402 U CN201514402 U CN 201514402U
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- fluid passage
- liquid
- switch valve
- pressure pump
- mixer
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Abstract
A high-performance chromatograph for circulating liquid phase belongs to the technical field of manufacturing of analytical instruments, and consists of a liquid accumulator, a mixer, a high-pressure pump, a sample injection machine, a chromatographic column, a detector and a recorder. A primary fluid passage switch valve is installed between the mixer and the high-pressure pump, and the other output port of the primary fluid passage switch valve is connected with a liquid dropping machine which is connected with an output port of the detector by a secondary fluid passage switch valve; and the liquid dropping machine consists of a hopper and a dropper. When in work, the following steps are conducted: firstly mixing a mobile phase by the mixer, then guiding the mixture into a high-pressure pump by the primary fluid passage switch valve, and then controlling the second fluid passage switch valve to switch the mobile phase into a main fluid passage when sample is injected in the chromatographic column by the sample injection machine, and after solvent peak flows out, and simultaneously, controlling the primary fluid passage switch valve to communicate the liquid dropping machine and the high-pressure pump, thus realizing the function of circulating liquid phase. The high-performance chromatograph for circulating liquid phase has super strong chromatograph separation capability, and can separate the mixture which can not be separated on a common chromatograph for preparing the liquid phase.
Description
Technical field:
The utility model belongs to analytical instrument manufacturing technology field, is a kind of high performance liquid chromatogram tripping device.
Background technology:
Existing high performance liquid chromatograph mainly is made of reservoir, mixer, high-pressure pump, injector, chromatographic column, detecting device and registering instrument.Moving phase in the reservoir is squeezed into system through mixer by high-pressure pump, sample solution enters system's stream through injector, be written in the chromatographic column by moving phase, because each component in the sample solution has difference on translational speed, be separated into single component and flow out in post successively, during by detecting device, sample concentration is converted into electric signal and is sent to registering instrument, data print with the collection of illustrative plates form, and moving phase is discharged by the output port of detecting device.At present, preparative high-performance liquid chromatographic has become the main separation means of pharmaceutical industry.But still have the chromatographic behavior of a lot of compounds very similar, as steric isomer, diastereo-isomerism.Separate the very challenging property of these compounds.Often can only reach part to these compounds separates.Use longer chromatographic column can obtain better degree of separation, but can be subjected to the restriction that these chromatographic columns produce higher back-pressure.In addition, the organic solvent consumption of common preparation liquid phase is very big, and environment is polluted.
Summary of the invention:
The technical problems to be solved in the utility model is to disclose a kind of circulation high performance liquid chromatograph with superpower separating power.
The scheme of the utility model technical solution problem is that the one-level flow channel switching valve is housed between mixer and high-pressure pump, another output port of one-level flow channel switching valve is connected with liquid-drop machine, liquid-drop machine is by the output port of secondary flow channel switching valve connection detector, liquid-drop machine is made of funnel and dropper, funnel bottom connects the one-level flow channel switching valve, dropper connects the secondary flow channel switching valve, and dropper is above funnel.During work, moving phase is at first mixed then by one-level flow channel switching valve importing high-pressure pump through mixer, after sample injects chromatographic column by injector, the time portion of checkmating earlier imports waste liquid by the secondary flow channel switching valve, to prevent that solvent peak from disturbing separated material signal, after treating that solvent peak flows out, control secondary flow channel switching valve switches to moving phase in the primary flow path.Control the one-level flow channel switching valve simultaneously liquid-drop machine and high-pressure pump are communicated with, realize circulation liquid phase function.At any time by the detector monitors signal.After material to be separated separated fully, control one-level flow channel switching valve was communicated with mixer again with infusion pump, controls the secondary flow channel switching valve simultaneously detecting device and liquid-drop machine are cut off, and open the floss hole of secondary flow channel switching valve.The moving phase and the liquid-drop machine that flow out from detecting device are not airtight, and a little moving phase (what can be decided according to the model and the stroke of used chromatogram infusion pump, are example with Waters 600E chromatographic system, approximately need 200 microlitres) is housed in the funnel type container in advance.Moving phase is to enter liquid-drop machine in the mode that splashes into, and so both can prevent that bubble from entering high-pressure pump, has also guaranteed detecting device and atmosphere UNICOM, has realized circulatory function simultaneously.
The utlity model has superpower chromatogram separating capacity.Can be separated in the potpourri that can't separate on the common preparative liquid chromatography.Used moving phase is 1/5 to 1/10 of common liquid chromatography simultaneously, and simple in structure, easy to operate.
Description of drawings:
Fig. 1 is the utility model structural representation;
Fig. 2 is the cut-open view of liquid-drop machine;
Fig. 3 is the circulation high-efficient liquid phase chromatogram.
Embodiment:
The utility model is made of reservoir 1, mixer 2, high-pressure pump 3, injector 4, chromatographic column 5, detecting device 6 and registering instrument 7, between mixer 2 and high-pressure pump 3, one-level flow channel switching valve 10 is housed, another output port of one-level flow channel switching valve 10 is connected with liquid-drop machine 9, liquid-drop machine 9 is by the output port of secondary flow channel switching valve 8 connection detectors 6, liquid-drop machine 9 is made of dropper 11 and funnel 12, funnel 12 bottoms connect one-level flow channel switching valve 10, dropper 11 connects secondary flow channel switching valve 8, and dropper 11 is above funnel 12.
Claims (1)
1. circulation high performance liquid chromatograph, constitute by reservoir, mixer, high-pressure pump, injector, chromatographic column, detecting device and registering instrument, it is characterized in that: the one-level flow channel switching valve is housed between mixer and the high-pressure pump, another output port of one-level flow channel switching valve is connected with liquid-drop machine, liquid-drop machine is by the output port of secondary flow channel switching valve connection detector, liquid-drop machine is made of funnel and dropper, funnel bottom connects the one-level flow channel switching valve, dropper connects the secondary flow channel switching valve, and dropper is above funnel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009200942731U CN201514402U (en) | 2009-08-28 | 2009-08-28 | High-performance chromatograph for circulating liquid phase |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009200942731U CN201514402U (en) | 2009-08-28 | 2009-08-28 | High-performance chromatograph for circulating liquid phase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201514402U true CN201514402U (en) | 2010-06-23 |
Family
ID=42485815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009200942731U Expired - Fee Related CN201514402U (en) | 2009-08-28 | 2009-08-28 | High-performance chromatograph for circulating liquid phase |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201514402U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102221584A (en) * | 2011-03-30 | 2011-10-19 | 安徽皖仪科技股份有限公司 | Cycling screening chromatographic apparatus for liquid chromatograph and method thereof |
| CN104422735A (en) * | 2013-08-19 | 2015-03-18 | 中国科学院大连化学物理研究所 | Preparative circulating chromatography apparatus |
| CN109374799A (en) * | 2018-09-13 | 2019-02-22 | 泰州成医药开发有限公司 | A kind of circulatory system and its control method of high performance liquid chromatograph mobile phase |
-
2009
- 2009-08-28 CN CN2009200942731U patent/CN201514402U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102221584A (en) * | 2011-03-30 | 2011-10-19 | 安徽皖仪科技股份有限公司 | Cycling screening chromatographic apparatus for liquid chromatograph and method thereof |
| CN104422735A (en) * | 2013-08-19 | 2015-03-18 | 中国科学院大连化学物理研究所 | Preparative circulating chromatography apparatus |
| CN109374799A (en) * | 2018-09-13 | 2019-02-22 | 泰州成医药开发有限公司 | A kind of circulatory system and its control method of high performance liquid chromatograph mobile phase |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100623 Termination date: 20170828 |