CN202994745U - Reagent kit for screening neonate inherited metabolic diseases - Google Patents
Reagent kit for screening neonate inherited metabolic diseases Download PDFInfo
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- CN202994745U CN202994745U CN201220479072.5U CN201220479072U CN202994745U CN 202994745 U CN202994745 U CN 202994745U CN 201220479072 U CN201220479072 U CN 201220479072U CN 202994745 U CN202994745 U CN 202994745U
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- reagent bottle
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- holder
- reagent
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Abstract
The utility model relates to a container, in particular to a reagent kit for screening neonate inherited metabolic diseases. The reagent kit comprises a box body, a box cover, at least five reagent bottles, a 96-hole plate and a fixing seat. The fixing seat is placed at the bottom of the box body. All reagent bottles are respectively connected with the fixing seat in a detachable mode and are fixed in the box body through the fixing seat. The 96-hole plate is placed above the reagent bottles.
Description
Technical field
The utility model relates to a kind of container, specifically a kind of kit for the examination of neonate's Inherited Metabolic Disorders.
Background technology
Inherited metabolic disease claims again inborn error of metabolism (IEM), is a class hereditary disease that causes heredity biochemical metabolism functional defect to cause by gene mutation, mostly is single gene inheritance disease, as geneogenous metabolic deficiencies such as amino acid, organic acid, fatty acid.At present generally by the neonate is carried out examination or detection, to detect this type of Inherited Metabolic Disorders.Because need the kinds of Diseases of detection many, so generally adopt tandem mass spectrum, by Isotopic Internal Standard, the amino acid in neonate's Filter Paper Dry Blood sheet sample, the concentration of fatty acyl carnitine analyzed; Once experiment can be analyzed tens kinds of heredity metabolize diseases that comprise amino acid, organic acid and fatty acid simultaneously, has greatly improved detection efficiency.
Need a kind of comprehensive kit to detect simultaneously various Inherited Metabolic Disorders on market, present each laboratory need to buy Isotopic Internal Standard and other organic reagents prepare blood of neonate sheet sample, grope simultaneously suitable extraction solution, derivatization reagent and upper required liquid phase separation condition and the Mass Spectrometer Method condition of machine testing, this needs expensive manpower and financial resources.If a kind of comprehensive kit can be provided, the inside comprises the preparation of blood sheet sample and required material and the method for upper machine testing, can save time like this and cost, within very short time, blood sheet sample be carried out express-analysis, give the patient a in time analysis report of satisfaction.
In view of this, the purpose of this utility model is to provide a kind of new screening test agent box, can carry simultaneously easily new screening and survey required reagent, and provide blood of neonate sheet sample to prepare and the UPLC-MS detection method, simultaneously simple in structure, easy to use, easy to manufacture.
The utility model content
The purpose of this utility model is to provide the kit of a kind of neonate's of can be used for Inherited Metabolic Disorders examination.
The utility model is achieved in the following ways:
A kind of detection kit, comprise box body, lid, reagent bottle, 96 orifice plates and holder, described reagent bottle is at least 5, described holder is positioned over bottom box body, described each reagent bottle is connected with removably with holder respectively, each reagent bottle is fixed in box body by holder, and described 96 orifice plates are positioned over above reagent bottle.
Above-mentioned box body can be rectangular parallelepiped, square, right cylinder, six prisms or rhombus quadrangular etc., is preferably rectangular parallelepiped.
Above-mentioned lid can be connected also and can not connect with box body.
Described box body is preferably long 12-18cm, wide 8-14cm, high 10-16cm.
The number of mentioned reagent bottle is preferably 5.Shape size can be identical also different.
Above-mentioned holder is placed on the bottom of box body, and shape size and box body bottom matches.
Described holder is preferably and highly is no more than 1/4th of box body.
Above-mentioned holder upper surface is provided with and the identical hole of reagent bottle bottom size shape, and is fixing to facilitate reagent bottle to insert.Arrange with uniform distances between hole, be evenly distributed on holder.The degree of depth that is preferably hole is no more than 1/2nd of reagent bottle height.
Label on the mentioned reagent bottle.Further these labels can mark extraction solution, amino acid Isotopic Internal Standard working fluid, carnitine Isotopic Internal Standard working fluid, derivatization reagent and flow and equate printed words.Preferably, adopt different colours reagent bottle or different colours label that reagent bottle institute installed reagents is distinguished.
Extraction solution, amino acid Isotopic Internal Standard working fluid, carnitine Isotopic Internal Standard working fluid, derivatization reagent and mobile phase are housed respectively in the mentioned reagent bottle.
The shape of mentioned reagent bottle can be rectangular parallelepiped, square, right cylinder, six prisms or rhombus quadrangular etc., is preferably column type.
Above-mentioned 96 orifice plates comprise at the bottom of flat and V-type each.
Optionally, also comprise operational manual in kit.
Description of drawings
Fig. 1 kit stereographic map
Main drawing reference numeral explanation
1, box body 2, holder 3, hole
4, reagent bottle 5, label 6,96 orifice plates
7, operational manual 8, lid
Embodiment
Embodiment one
The kit that can be used for the examination of neonate's Inherited Metabolic Disorders that the utility model provides comprises box body 1, lid 8, reagent bottle 4,96 orifice plates 6 and holder 2.
In the present embodiment, box body 1 is rectangular parallelepiped, long 12cm, wide 8cm, high 10cm.
In the present embodiment, reagent bottle 4 is set to 5, and shape size differs.Each reagent bottle 4 is connected with removably with holder 2 respectively, and each reagent bottle 4 is fixed in box body 1 by holder 2.On reagent bottle 4, label 5.Label 5 marks respectively extraction solution, amino acid Isotopic Internal Standard working fluid, carnitine Isotopic Internal Standard working fluid, derivatization reagent and flow and equate printed words.
96 orifice plates 6 comprise at the bottom of flat and V-type each.96 orifice plates 6 are positioned over reagent bottle 4 tops.
Claims (9)
1. kit that is used for the examination of neonate's Inherited Metabolic Disorders, it is characterized in that: comprise box body, lid, reagent bottle, 96 orifice plates and holder, described reagent bottle is at least 5, described holder is positioned over bottom box body, described each reagent bottle is connected with removably with holder respectively, each reagent bottle is fixed in box body by holder, and described 96 orifice plates are positioned over above reagent bottle.
2. kit according to claim 1, it is characterized in that: described box body is rectangular parallelepiped, square, right cylinder, six prisms or rhombus quadrangular.
3. kit according to claim 1, it is characterized in that: described lid can be connected also and can not connect with box body.
4. kit according to claim 1, it is characterized in that: the number of reagent bottle is 5.
5. kit according to claim 1, it is characterized in that: described holder is placed on the bottom of box body, and size shape and box body bottom match.
6. kit according to claim 1 is characterized in that: the hole that described holder upper surface is provided with and reagent bottle bottom size shape is coincide, and fixing to facilitate reagent bottle to insert.
7. kit according to claim 1, is characterized in that: according to reagent bottle size, splendid attire extraction solution, amino acid Isotopic Internal Standard working fluid, carnitine Isotopic Internal Standard working fluid, derivatization reagent and mobile phase respectively.
8. kit according to claim 1, it is characterized in that: described reagent bottle is shaped as column type.
9. kit according to claim 1 is characterized in that: described 96 orifice plates comprise flat and V-type at the bottom of each.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201220479072.5U CN202994745U (en) | 2012-09-19 | 2012-09-19 | Reagent kit for screening neonate inherited metabolic diseases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201220479072.5U CN202994745U (en) | 2012-09-19 | 2012-09-19 | Reagent kit for screening neonate inherited metabolic diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202994745U true CN202994745U (en) | 2013-06-12 |
Family
ID=48565915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201220479072.5U Expired - Lifetime CN202994745U (en) | 2012-09-19 | 2012-09-19 | Reagent kit for screening neonate inherited metabolic diseases |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202994745U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104237442A (en) * | 2014-10-11 | 2014-12-24 | 杨绪庆 | Reagent kit, application of reagent kit and multiple amino acid and carnitine joint-detection method |
| CN108645924A (en) * | 2017-06-22 | 2018-10-12 | 南方医科大学 | The detection method of metabolism in newborn infants object based on ultra performance liquid chromatography tandem mass spectrum technology |
-
2012
- 2012-09-19 CN CN201220479072.5U patent/CN202994745U/en not_active Expired - Lifetime
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104237442A (en) * | 2014-10-11 | 2014-12-24 | 杨绪庆 | Reagent kit, application of reagent kit and multiple amino acid and carnitine joint-detection method |
| CN104237442B (en) * | 2014-10-11 | 2015-10-07 | 杨绪庆 | The method of kit and application and joint-detection several amino acids and carnitine |
| CN108645924A (en) * | 2017-06-22 | 2018-10-12 | 南方医科大学 | The detection method of metabolism in newborn infants object based on ultra performance liquid chromatography tandem mass spectrum technology |
| CN108645924B (en) * | 2017-06-22 | 2021-07-20 | 南方医科大学 | Detection method of metabolite of newborn based on ultra-high performance liquid chromatography tandem mass spectrometry technology |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: NANJING HUADA GENE TECHNOLOGY CO., LTD. Effective date: 20130916 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20130916 Address after: Beishan Industrial Zone Building in Yantian District of Shenzhen city of Guangdong Province in 518083 Patentee after: BGI SHENZHEN Patentee after: Nanjing Huada Gene Technology Co.,Ltd. Address before: Beishan Industrial Zone Building in Yantian District of Shenzhen city of Guangdong Province in 518083 Patentee before: BGI SHENZHEN |
|
| CX01 | Expiry of patent term |
Granted publication date: 20130612 |
|
| CX01 | Expiry of patent term |