CN202658158U - Intelligent analog control device for organism gastrointestinal tract digestive system - Google Patents
Intelligent analog control device for organism gastrointestinal tract digestive system Download PDFInfo
- Publication number
- CN202658158U CN202658158U CN 201220211927 CN201220211927U CN202658158U CN 202658158 U CN202658158 U CN 202658158U CN 201220211927 CN201220211927 CN 201220211927 CN 201220211927 U CN201220211927 U CN 201220211927U CN 202658158 U CN202658158 U CN 202658158U
- Authority
- CN
- China
- Prior art keywords
- control device
- body pipe
- intelligent
- digestive
- pipe intestinal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Abstract
The utility model provides an intelligent analog control device for an organism gastrointestinal tract digestive system. The device comprises a plurality of airtight interlayer light storage tanks which are used for simulating all parts of the organism gastrointestinal tract digestive system; inner tanks are used for accommodating digestive juice; interlayer parts are fully filled with circulating water to ensure the constant temperature of the whole system; and biological digestion is simulated by magnetic stirring, and the digestive juice among all glass tanks is transferred through peristaltic pumps at regular time. Based on different conditions such as pH values required by the growth of microorganisms, an HCl or NaOH solution can be added through a pH value controller, so that the pH values can be kept in a required normal pH value range. Various sensors such as pressure sensors, temperature sensors and enzyme sensors can be arranged at the upper ends of the liquid storage tanks, so that the digestive juice of the inner tanks can be measured and adjusted on line in real time. The aim of intelligently controlling all the devices of the whole control device can be fulfilled by connecting a serial interface with a computer and setting and controlling parameters through special software.
Description
Technical field
The utility model relates to a kind of intelligent biology body pipe intestinal digesting systems simulation control device, life habit for different organisms, organism gastrointestinal physiology functional status is carried out the device of conditions in vitro Imitating, this device can be to the pH value of digestive tube inside, the parameters such as pressure, temperature, enzyme are measured and are automatically regulated, to reach the purpose at external reproduction organism gastrointestinal system.
Background technology
Because the extensive pollution in the excessive use of fertilizer and pesticide etc. and water body, farmland, the food of production has also accumulated the various pollutents such as plurality of heavy metal and agricultural chemicals, eats HUMAN HEALTH is constituted a serious threat.The biological effectiveness generally experiment made on the living (in vivo) by animal (goose, mouse) obtains, but have that experimental period is long, expense is high, the shortcoming such as poor reproducibility as a result.Experiment in vitro (in vitro, or claim simulated experiment) time is short, expense is cheap, as a result favorable reproducibility, be easy to the simplification design of complex experiment, and the Fast Measurement of suitable batch samples, therefore the extracorporeal simulating experiment of gastro-intestinal system becomes a kind of method of very effective assessment pollutent biological effectiveness, and reaches its maturity in methodology.
The microorganism of the Adsorption and desorption of pollutent and metamorphosis and environment is closely related in the environment, particularly plays vital effect aspect the pollutent decomposition and inversion of anaerobion in environment.And in human body alimentary canal, particularly have a large amount of anaerobions in the large intestine.Gross weight in the enteron aisle of present known normal adult has 1 ~ 2 kg, comprises approximately 500 ~ 1000 different kinds, its cell total amount (10
14) be 10 times of human body self cell, the gene dosage of its coding is to be more than 100 times of human body autogene, is containing the genetic information of magnanimity.The aspects such as intestinal microflora and host's digestion, nutrition, metabolism, immunity are closely related, are " environment " factors that enters human body, and its status and effect are equivalent to acquired one important " organ ".The huge microbial population of quantity like this, the common evolution by long-term and host is having very important effect aspect the nutrition and metabolism regulation and control, enzyme and the biochemical metabolism path that does not possess is provided for the host.The material that helps the Host Digestion human body directly not digest is such as vegetable polysaccharidess such as Mierocrystalline cellulose, hemicellulose, colloid, starch.The enteric microorganism genome is " human second genome " of control HUMAN HEALTH, with human genome, by interacting with envrionment conditions, affects the physiological metabolism of human body.After the noxious pollutant that enters human body by food enters large intestine, in large intestine under the effect of anaerobion, its biological effectiveness, form, the aspects such as toxicity all may change.
The method that multiple in-vitro simulated stomach and intestine are arranged at present comprises physiology principle extraction method (PBET), external stomach and intestine method (IVG), and validity is simplified extraction method (SBET) etc.These methods more stress with Digestive tract in the Digestive system such as enzyme on the impact of pollutent biological effectiveness, do not consider the effect of large intestine and large intestine microorganism, be not a complete Digestive tract.The human intestinal microorganism simulator (SHIME) of Ghent, Belgium university invention is also simulated except simulation stomach and small intestine and have been cultivated the large intestine microorganism, comprises the ascending colon, transverse colon, descending colon, controls the microorganism species of different steps by accurate control pH.This has not only simulated whole Digestive tract, can also investigate the metabolism behavior of large intestine microbe.
Take into full account different organisms, food classifications etc. are the larger difference of digestive process aspect on the feed, this research improves the SHIME system, make it easy to the needs according to research, simulation arranges differential responses system and various parameter, and various parameters are regulated in intellectuality as requested, to reach the physiological environment that can simulate multiple organism Digestive tract, for the validity of noxious pollutant in the various foods of accurate evaluation, conversion etc., provide technical support.
Summary of the invention
The purpose of this utility model is original SHIME device is carried out technological improvement, its range of application is expanded, not only be practically applicable to human gastrointestinal tract microbial ecological simulation under the conditions in vitro, also can under conditions in vitro, reappear the simulation of other organism gi tract and microecosystem.By the intellectuality control pH value to digestive tube inside, the parameters such as pressure, temperature, enzyme are measured and are automatically regulated, and with realization the gastrointestinal physiology functional status of different kind organism complexity are carried out simulation under the conditions in vitro.
The present utility model is a kind of intelligent biology body pipe intestinal digesting systems simulation control device, comprise a plurality of hermetic type interlayer container for storing liquids for simulation organism pipe intestinal digesting system each several part, this interlayer container for storing liquid comprises: all kinds of Digestive systems of storage, the inner canister of tetrafluoroethylene material, and glass material outer tank, sandwich portion in interior outer tank is full of thermostatical circulating water, be communicated with by polyfluortetraethylene pipe between each outer tank and be connected to constant temperature water bath apparatus, thereby reach the constant temperature purpose, wherein the concrete category simulated as required of water temperature is set.Each several part digestion wriggling stirs by the magnetic stirring apparatus under each glass pot is simulated.Lid in the container for storing liquid upper end has several holes, regularly shift Digestive system between each glass pot by peristaltic pump, also can by peristaltic pump with certain pump speed rotating control, in container for storing liquid, automatically add, perhaps take out Digestive system, and carry out the analysis of material to taking out liquid.
Different based on the needed condition of microorganism growth condition, such as pH value, can be by pH value controller interpolation HCL or NaOH solution, to the control that automatically adjusts of solution in each glass pot, it is maintained in the required normal ph scope.Various kinds of sensors be can increase in the container for storing liquid upper end, such as pressure, temperature, Enzyme sensor, can real-time on-line determination and adjusting be carried out to the Digestive system of inner canister.
Whole control device comprises: several peristaltic pumps and pH value controller, one cover thermostatical circulating water temperature control e Foerderanlage, the control of all devices, all by behind the RS485 RS 232 transmodulator, be connected with computer by serial line interface, and carry out parameter setting and control by special software, reach quick, accurate, time saving and energy saving, the purpose of intelligent control.
Description of drawings
Fig. 1 is that the structure of the utility model embodiment forms schematic diagram.
Fig. 2 is the electric circuit constitute schematic diagram of the utility model embodiment.Wherein: the 12 gastric juice fluid reservoir 3 small intestine fluid reservoir 4 colon ascendens fluid reservoir 5 transverse colon fluid reservoir 6 transverse colon fluid reservoir 7 food liquid 8 gastric juice 9 intestinal fluid 10 waste liquid cylinder 11 HCL solution 12 NaOH solution 13 polyfluortetraethylene pipe 14 magnetic stirring apparatus 15 glass material outer tank 16 peristaltic pump control device A 17 peristaltic pump control device B 18 of the water bath with thermostatic control with EGR extract digestive juice peristaltic pump 19 pH value control device 20 pH value controllers 21 and extract acid & alkali liquid peristaltic pump 22 sensor device 23 RS485 RS 232 converter 24 computers.
Embodiment
The utility model is described in further detail below in conjunction with specific embodiments and the drawings.
As illustrated in fig. 1 and 2, take people's pipe intestinal digesting systems simulation as example, this model comprises 5 hermetic type container for storing liquids such as gastric juice container for storing liquid 2, small intestine container for storing liquid 3, ascending colon container for storing liquid 4, transverse colon container for storing liquid 5, transverse colon container for storing liquid 6, each container for storing liquid outside is by a glass outer tank 15, middle portion is full of recirculated water, is communicated and is connected to 37 degrees centigrade constant temperature water bath apparatus 1 to reach the constant temperature effect by polyfluortetraethylene pipe 13; Stomach and intestinal digestion wriggling is simulated by stirring with magnetic stirring apparatus 14 under each glass pot, upper end at each sealed can, several holes are arranged, can be connected with peristaltic pump control device B17 by peristaltic pump control device A16 and add in the glass pot (pump line be connected with peristaltic pump connection omit), as in gastric juice container for storing liquid 2, adding food liquid 7 and gastric juice 8 by extracting Digestive system peristaltic pump 18, in small intestine container for storing liquid 3, add intestinal fluid 9 etc.PH value in the digester of various piece is by pH value control device 19 and extract acid ﹠ alkali liquid peristaltic pump 21 and draw the purpose that HCL solution 11 or NaOH solution 12 reach automatic control.And regularly shifting Digestive system between each container for storing liquid by the peristaltic pump control device, last reaction solution is disposed to waste liquid cylinder 10.Be inserted with sensor device 22 in each digester upper end, such as the sensor to the temperature in the digester, enzyme content, pressure, the isoparametric the real time measure of pH value.Above parameter can have material impact to digestive tube physiological situation, food decomposition and dietetic alimentation.
Whole control device comprises: several peristaltic pumps and pH value controller, thermostatical circulating water temperature control e Foerderanlage, the control of all devices, all by behind the RS485 RS 232 transmodulator 23, are connected connection with computer by serial line interface, and carry out parameter setting and control by special software, reach quick, accurate, time saving and energy saving, the purpose of intelligent control.
Claims (7)
1. intelligent biology body pipe intestinal digesting systems simulation control device, it is characterized in that comprising in the device hermetic type glass pot, magnetic stirring apparatus, thermostatical circulating water temperature control e Foerderanlage, a plurality of peristaltic pump and pH value controller, the various kinds of sensors of a plurality of sandwichs, RS485 RS 232 transmodulator and dedicated operations software; The control of all devices all by behind the RS485 RS 232 transmodulator, is connected with computer by serial line interface, and carries out parameter setting and control by special software.
2. intelligent biology body pipe intestinal digesting systems simulation control device as claimed in claim 1 is characterized in that the hermetic type container for storing liquid inner canister of sandwich is the retort of tetrafluoroethylene material, and outer tank is the synthetic glass material, is full of recirculated water between interior outer tank.
3. intelligent biology body pipe intestinal digesting systems simulation control device as claimed in claim 1 is characterized in that simulating each several part digestion wriggling, employing be the magnetic stirrer Digestive system.
4. intelligent biology body pipe intestinal digesting systems simulation control device as claimed in claim 1 is characterized in that interpolation or the taking-up of all kinds of Digestive systems, and what select is peristaltic pump.
5. intelligent biology body pipe intestinal digesting systems simulation control device as claimed in claim 1, it is characterized in that guaranteeing that solution maintains in the required normal ph scope in each glass pot, be to cooperate by pH value controller and two peristaltic pumps, add HCl or NaOH solution.
6. intelligent biology body pipe intestinal digesting systems simulation control device as claimed in claim 1 is characterized in that the container for storing liquid upper end can increase various kinds of sensors, can carry out real-time on-line determination and adjusting to the Digestive system of inner canister.
7. intelligent biology body pipe intestinal digesting systems simulation control device as claimed in claim 1, it is characterized in that the control of all devices, all by behind the RS485 RS 232 transmodulator, be connected with computer by serial line interface, and pass through supporting special software and can carry out real-time parameter setting and intelligent control to each submodule device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220211927 CN202658158U (en) | 2012-05-14 | 2012-05-14 | Intelligent analog control device for organism gastrointestinal tract digestive system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220211927 CN202658158U (en) | 2012-05-14 | 2012-05-14 | Intelligent analog control device for organism gastrointestinal tract digestive system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202658158U true CN202658158U (en) | 2013-01-09 |
Family
ID=47453077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201220211927 Expired - Fee Related CN202658158U (en) | 2012-05-14 | 2012-05-14 | Intelligent analog control device for organism gastrointestinal tract digestive system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202658158U (en) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103439476A (en) * | 2013-08-30 | 2013-12-11 | 北京市环境保护科学研究院 | Turnover testing device and method for heavy metal availability by stimulating human digestion characteristics |
| CN103675205A (en) * | 2013-11-26 | 2014-03-26 | 南昌大学 | Device for simulating gastric digestion and using method of device |
| CN103740589A (en) * | 2014-01-09 | 2014-04-23 | 江南大学 | Human body gastrointestinal tract bionic system and simulation experiment method based on system |
| CN103820314A (en) * | 2013-12-05 | 2014-05-28 | 南昌大学 | Device for simulating large intestine glycolysis and using method thereof |
| CN103837655A (en) * | 2013-12-05 | 2014-06-04 | 南昌大学 | Device for simulation of digestion in small intestine and use method thereof |
| CN103926375A (en) * | 2014-03-12 | 2014-07-16 | 南昌大学 | Device for simulating human digestive and glycolytic system and application method thereof |
| CN104851346A (en) * | 2015-04-30 | 2015-08-19 | 暨南大学 | Modular animal digestive tract in-vitro simulation system and human intestinal tract simulation method thereof |
| CN106148180A (en) * | 2016-07-06 | 2016-11-23 | 南京大学 | A kind of for simulated environment pollutant in the apparatus and method of the digested absorption of digestive system |
| CN107909880A (en) * | 2017-12-29 | 2018-04-13 | 上海交通大学医学院附属瑞金医院 | One kind drainage tube assembly |
| CN109142365A (en) * | 2018-11-01 | 2019-01-04 | 西安交通大学医学院第附属医院 | A kind of simulated gastrointestinal condition experiment porch |
| CN110231437A (en) * | 2019-04-26 | 2019-09-13 | 合肥工业大学 | A kind of device that test-type automatic imitation stomach and intestine continuously digest and application method |
| WO2019203632A1 (en) * | 2018-04-19 | 2019-10-24 | Centro De Investigación Y Asistencia En Tecnología Y Diseño Del Estado De Jalisco A.C. | Compact system for simulating the human digestive tract |
-
2012
- 2012-05-14 CN CN 201220211927 patent/CN202658158U/en not_active Expired - Fee Related
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103439476B (en) * | 2013-08-30 | 2015-07-15 | 北京市环境保护科学研究院 | Turnover testing device and method for heavy metal availability by stimulating human digestion characteristics |
| CN103439476A (en) * | 2013-08-30 | 2013-12-11 | 北京市环境保护科学研究院 | Turnover testing device and method for heavy metal availability by stimulating human digestion characteristics |
| CN103675205A (en) * | 2013-11-26 | 2014-03-26 | 南昌大学 | Device for simulating gastric digestion and using method of device |
| CN103675205B (en) * | 2013-11-26 | 2016-09-28 | 南昌大学 | A kind of device simulating gastric digestion and using method |
| CN103820314A (en) * | 2013-12-05 | 2014-05-28 | 南昌大学 | Device for simulating large intestine glycolysis and using method thereof |
| CN103837655A (en) * | 2013-12-05 | 2014-06-04 | 南昌大学 | Device for simulation of digestion in small intestine and use method thereof |
| CN103740589A (en) * | 2014-01-09 | 2014-04-23 | 江南大学 | Human body gastrointestinal tract bionic system and simulation experiment method based on system |
| CN103926375A (en) * | 2014-03-12 | 2014-07-16 | 南昌大学 | Device for simulating human digestive and glycolytic system and application method thereof |
| CN104851346A (en) * | 2015-04-30 | 2015-08-19 | 暨南大学 | Modular animal digestive tract in-vitro simulation system and human intestinal tract simulation method thereof |
| CN106148180A (en) * | 2016-07-06 | 2016-11-23 | 南京大学 | A kind of for simulated environment pollutant in the apparatus and method of the digested absorption of digestive system |
| CN107909880A (en) * | 2017-12-29 | 2018-04-13 | 上海交通大学医学院附属瑞金医院 | One kind drainage tube assembly |
| CN107909880B (en) * | 2017-12-29 | 2023-06-23 | 上海交通大学医学院附属瑞金医院 | Human body closed cavity drainage model |
| WO2019203632A1 (en) * | 2018-04-19 | 2019-10-24 | Centro De Investigación Y Asistencia En Tecnología Y Diseño Del Estado De Jalisco A.C. | Compact system for simulating the human digestive tract |
| CN109142365A (en) * | 2018-11-01 | 2019-01-04 | 西安交通大学医学院第附属医院 | A kind of simulated gastrointestinal condition experiment porch |
| CN110231437A (en) * | 2019-04-26 | 2019-09-13 | 合肥工业大学 | A kind of device that test-type automatic imitation stomach and intestine continuously digest and application method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN202658158U (en) | Intelligent analog control device for organism gastrointestinal tract digestive system | |
| CN103740589B (en) | Human body gastrointestinal tract bionic system and simulation experiment method based on system | |
| Ji et al. | In vitro gastrointestinal digestion and fermentation models and their applications in food carbohydrates | |
| US20190228681A1 (en) | Visual Bionic Digestive System for Human Gastrointestinal Tract Model | |
| CN101565673B (en) | Intelligent bionic rumen fermenter | |
| Montoya et al. | Production of lignocellulolytic enzymes and biomass of Trametes versicolor from agro-industrial residues in a novel fixed-bed bioreactor with natural convection and forced aeration at pilot scale | |
| CN103675205A (en) | Device for simulating gastric digestion and using method of device | |
| CN105754852A (en) | Equipment and measuring method for simulating growth curves of microorganisms in high-temperature and high-pressure oil reservoirs | |
| Chorukova et al. | Two-Phase Anaerobic Digestion of Corn Steep Liquor in Pilot Scale Biogas Plant with Automatic Control System with Simultaneous Hydrogen and Methane Production | |
| CN111778153A (en) | Continuous in-vitro simulated human intestinal flora fermentation equipment and method | |
| CN104585510B (en) | A kind of mixed fungus fermentation thing feed addictive and preparation method thereof | |
| Zieliński et al. | Microwave radiation influence on dairy waste anaerobic digestion in a multi-section hybrid anaerobic reactor (M-SHAR) | |
| CN102286359A (en) | Solid-liquid-gas three phase flow-dividing rumen imitation continuous fermentation system and method | |
| Wang et al. | Optimization of growth requirements and scale‐up cultivation of freshwater algae Desmodesmus armatus using response surface methodology | |
| CN209894792U (en) | Experimental device for automatically simulating gastrointestinal continuous digestion | |
| CN209625582U (en) | A kind of semi-permeable membrane judicial entity alimentary canal simulator | |
| Andrianou et al. | Upcycled Animal Feed: Sustainable Solution to Orange Peels Waste | |
| CN202116557U (en) | Small-sized fermentation equipment | |
| CN207503515U (en) | A kind of human gastrointestinal tract in vitro digestion device | |
| Hernalsteens et al. | The final fate of food: On the establishment of in vitro colon models | |
| CN204625617U (en) | Artificial rumen simulator | |
| Gonde et al. | pH-based control of anaerobic digestion to maximise ammonium production in liquid digestate | |
| Mäkivuokko et al. | In vitro methods to model the gastrointestinal tract | |
| CN207619409U (en) | A kind of external digestion system simulator | |
| CN204625616U (en) | Emulation rumen fermenter |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130109 Termination date: 20210514 |