CN207503515U - A kind of human gastrointestinal tract in vitro digestion device - Google Patents
A kind of human gastrointestinal tract in vitro digestion device Download PDFInfo
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- CN207503515U CN207503515U CN201721146538.9U CN201721146538U CN207503515U CN 207503515 U CN207503515 U CN 207503515U CN 201721146538 U CN201721146538 U CN 201721146538U CN 207503515 U CN207503515 U CN 207503515U
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- 230000029087 digestion Effects 0.000 title claims abstract description 24
- 238000000338 in vitro Methods 0.000 title claims abstract description 24
- 210000001035 gastrointestinal tract Anatomy 0.000 title claims abstract description 23
- 230000007246 mechanism Effects 0.000 claims abstract description 50
- 230000002572 peristaltic effect Effects 0.000 claims abstract description 39
- 239000000463 material Substances 0.000 claims abstract description 28
- 229920001296 polysiloxane Polymers 0.000 claims abstract description 22
- 239000011229 interlayer Substances 0.000 claims abstract description 16
- 238000006243 chemical reaction Methods 0.000 claims abstract description 9
- 239000007788 liquid Substances 0.000 claims description 30
- 239000002253 acid Substances 0.000 claims description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 24
- 239000003513 alkali Substances 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 22
- 230000008676 import Effects 0.000 claims description 10
- 238000004891 communication Methods 0.000 claims description 4
- 239000011521 glass Substances 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 2
- 239000000741 silica gel Substances 0.000 claims description 2
- 229910002027 silica gel Inorganic materials 0.000 claims description 2
- 238000004088 simulation Methods 0.000 abstract description 12
- 238000011160 research Methods 0.000 abstract description 8
- 230000003285 pharmacodynamic effect Effects 0.000 abstract description 4
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- 235000016709 nutrition Nutrition 0.000 abstract description 3
- 230000035764 nutrition Effects 0.000 abstract description 3
- 230000002349 favourable effect Effects 0.000 abstract 1
- 210000000214 mouth Anatomy 0.000 description 17
- 230000008569 process Effects 0.000 description 17
- 210000002784 stomach Anatomy 0.000 description 12
- 230000001079 digestive effect Effects 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 230000000968 intestinal effect Effects 0.000 description 5
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- 241001465754 Metazoa Species 0.000 description 4
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- 210000000813 small intestine Anatomy 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 238000001514 detection method Methods 0.000 description 3
- 210000002249 digestive system Anatomy 0.000 description 3
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- 235000011389 fruit/vegetable juice Nutrition 0.000 description 3
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- 238000004519 manufacturing process Methods 0.000 description 2
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Abstract
The utility model discloses a kind of human gastrointestinal tract in vitro digestion device, including two retort, middle part bindiny mechanism, Liang Ge ends bindiny mechanism, controller, material peristaltic pump and pressure peristaltic pump；Retort both ends open is internally provided with silicone tube, and silicone tube both ends are tightly connected respectively with retort both ends, surrounds independent interlayer cavity with reacting top tank structure, reaction tank skin connects interlayer cavity with pressure export equipped with pressure inlets；The one end open of two retort is connected by middle part bindiny mechanism, another opening of two retort is respectively communicated with an end bindiny mechanism；Material mouth is provided in the bindiny mechanism of end；Controller connects control material peristaltic pump and pressure peristaltic pump；Material peristaltic pump connects material mouth；Pressure peristaltic pump connects the pressure inlets or pressure export.The utility model simulation is true, favorable reproducibility, suitable for the research of the technical fields such as microbiology, pharmacodynamics, toxicology and nutrition.
Description
Technical field
The utility model belongs to bionics, microbiology, pharmacodynamics, toxicology, nutrition and analysis and testing technology field.
The utility model is related to a kind of in-vitro simulated device of human gastrointestinal tract, specifically, being to be related to a kind of conditions in vitro Imitating food
The device for being digested, absorbing in human gastrointestinal tract difference enteric cavity.
Background technology
The digestive system of human body is mainly made of alimentary canal and glandula digestive.Alimentary canal since oral cavity, be followed successively by down pharynx,
Esophagus, stomach, small intestine, large intestine；Glandula digestive includes salivary gland, pancreas, liver, gastric gland and enteraden.The major function of digestive system is
Intake, absorbs nutriment, excludes swill digestion food.Human body for food to digest and assimilate process extremely complex,
Digestion process refers mainly to that food resolves into digest tube can absorbed small-molecule substance；Absorption process is the object in digest tube
Matter enters the process of blood and lymph through alimentary canal mucous membrane.In the digestion process of human body, two main process are digested and assimilated
Almost occur simultaneously.Digestion becomes research in the fields such as microbiology, pharmacodynamics, toxicology, nutrition at present
Hot spot.However, the human relations involved in due to the complexity of digestion, the finiteness of scientific research technology and In vivo study process
Reason constraint, the research of digestion are difficult always.Therefore there is an urgent need to a set of flexible, accurately, again for academia
The model of the physiology courses such as the good in-vitro simulated human consumption absorption of renaturation energy.
In recent years, the in-vitro simulated device of human and animal's alimentary canal is constantly promoted, these simulators are in microorganism
, pharmacodynamics, toxicology, the research field of the mankind and animal nutrition are used widely, and are gradually received by academia, certain
Simulator can even be used as production equipment, and production needs certain active materials of specific intestinal environment or the activation of intestines bacterium.This
The external digestion road simulator having disclosed a bit is respectively provided with following similar Design theory：Simulate the different alimentary canals such as stomach, small intestine
The core component at position is closed reaction vessel in varying numbers, by adding different digestion into closed reaction vessel
Liquid, the suitable pH value of regulation and control and then environment substantially in the simple analog mankind and animal alimentary canal, and each simulator is equipped with
There are the action components such as peristaltic pump, magnetic stirring apparatus, temperature sensor.
Human vitronectin GIT model is directed to, design is roughly divided into four kinds, and respectively static one compartment model moves
State one compartment model, dynamic fixed double chamber bed and dynamic multi compartment model.Static one compartment model is represented as Dutch scientist
The pipe intestinal digesting system of the exploitation in 2002 such as A.G.Oomen, for the system only comprising a retort, digestive juice only includes saliva
Liquid, gastric juice, pancreatic juice and bile.Although the digestive system is widely used, the static limitation of its system can not be simulated
Physiology, biochemistry and the physicochemical property process of human body alimentary canal complexity.At present, human gastrointestinal tract external digestion model essence the most advanced
True is the TIM systems of Dutch TNO designs, which is a set of dynamic controlled by computer, multi-chamber systems, main analog
Three stomach, small intestine, large intestine alimentary canals control food chewing, digestion, absorption and gastric emptying process by computer control system,
Human gastrointestinal tract digestion process is accurately reappeared.China is relatively stagnant for human gastrointestinal tract in vitro digestion systematic research
Afterwards, mechanism only few in number at present carries out the research of device and method, such as invention patent mandate CN102533543A public affairs
A kind of human body intestinal canal environment that can simulate is opened for the device that enteric microorganism is cultivated, which provides and maintain given pace
Oscillation, relative constant temperature, humidity achieve the effect that simulate human body intestinal canal environment.Utility model patent grant number
CN201344874Y discloses a kind of animal imitating digester, by injecting the difference such as Stomach duodenum into dialysis tubing
The buffer solution that the digestive juice of alimentary canal section and corresponding change are passed through in glass tube is, it can be achieved that simulation feed is moving under in vitro conditions
The situation of absorption is digested in each section of object pipe intestinal digesting road.Invention patent mandate CN103740589A discloses a kind of human body
Gastrointestinal tract bionic system and the analogue experiment method based on the system, the system can real simulation isolated conditions by intelligent control
Lower food digesting and assimilating in human gastrointestinal tract.Invention patent mandate CN104851346A discloses a kind of modularization animal
The in-vitro simulated system of alimentary canal and its human intestine's analogy method.The system simulates stomach, small intestine, the colon ascendens, transverse colon, drop knot
Five alimentary canals of intestines, and multiple function modules are integrated in the frame, retort and function mould are controlled by intelligence control system
Block realizes and samples automatically, automatically saves sample parameters.
However, above-mentioned disclosed in-vitro simulated apparatus system all exists the defects of itself, if device is substantially all using magnetic
The wriggling function of power blender simulated gastrointestinal tract, in gastrointestinal tract simulated experiment, magnetic stirring apparatus needs energy continuous work at least
200 hours, but general magnetic stirring apparatus is unable to continuous work 10 hours or more.And with sensor and accurate control technique
Progress, must occur the information of more controllable components or acquisition in future models.Existing apparatus can not be kept away in design
Exempt to encounter structural adjustment or modification, intelligence control system also inevitable deeply accordingly being improved with research.
Utility model content
In view of the above-mentioned problems, the purpose of this utility model is to provide a kind of human gastrointestinal tract in vitro digestion device, it should
Gastrointestinal tract simulation digester true simulation food can be digested in human gastrointestinal tract difference enteric cavity, inhale under in vitro conditions
The situation of receipts.
To achieve these goals, the utility model employs following technical scheme：
A kind of human gastrointestinal tract in vitro digestion device, the in-vitro simulated device of human body alimentary canal include two retort,
Middle part bindiny mechanism, Liang Ge ends bindiny mechanism, controller, material peristaltic pump and pressure peristaltic pump；
Include to accommodate the cavity of liquid in the middle part bindiny mechanism and end bindiny mechanism；
The retort both ends open；The retort is internally provided with silicone tube, the silicone tube both ends respectively with instead
Tank both ends is answered to be tightly connected, the silica gel pipe outer wall surrounds independent interlayer cavity, the silicone tube with the top tank structure that reacts
The internal open communication with the retort both ends；It is described reaction tank skin be equipped with pressure inlets and pressure export, the pressure into
Mouth connects the interlayer cavity with pressure export；
The one end open of described two retort is connected by the cavity in the middle part bindiny mechanism, described two reactions
Another opening of tank is respectively communicated with the cavity of an end bindiny mechanism；
Material mouth is provided in the end bindiny mechanism, the material mouth connects the cavity of the end bindiny mechanism；
The controller connection controls the material peristaltic pump and the pressure peristaltic pump；The material peristaltic pump connects institute
State material mouth；The pressure peristaltic pump connects the pressure inlets or pressure export.
Temperature incubation function can be realized by being passed through constant-current constant-temperatureself-injection water into the interlayer cavity.
Further, linker has been provided with outside the in-vitro simulated unit of the human body alimentary canal, the linker connects institute
State pressure inlets or pressure export.By installing contact-free level instrument and linker can realize inspection to liquid level in tank
It surveys, realizes the measure to tank intraformational bed cavity volume.
Further, acid ＆ alkali liquid import is provided at least one end bindiny mechanism, the acid ＆ alkali liquid import connects
Lead to the cavity of the end bindiny mechanism.
Further, pH meter mouth is provided in the middle part bindiny mechanism, the pH meter mouth connects the middle part connection machine
The cavity of structure；PH meter is provided in the pH meter mouth, the pH meter connects controller；The controller control is connected with acid ＆ alkali liquid
Peristaltic pump, the acid ＆ alkali liquid peristaltic pump connect the acid ＆ alkali liquid import.Target ph is set by controller, if pH is less than minimum
Value or maximum value, start acid ＆ alkali liquid peristaltic pump, towards simulation reaction tank in inject diluted lye or acid solution, reach desired value
Afterwards, stop acid ＆ alkali liquid peristaltic pump.
Further, the opening at the retort both ends is ground, by flange and the middle part bindiny mechanism or described
End bindiny mechanism connects.
Further, the both ends of the silicone tube are routed up outside the opening of the retort.
Further, the retort is cylindrical tank.
Further, the retort is the glass material of high-temperature-resistant high-pressure-resistant.
Further, the human gastrointestinal tract in vitro digestion device further includes humidity control system, and the temperature is adjusted
System includes sealed constant temperature water tank and temperature sensor；The constant temperature water tank is controlled by the controller, and the controller connects
The temperature sensor is connect, the temperature sensor is set in the constant temperature water tank.Set fluid temperature in constant temperature water tank
Desired value, maximum value, minimum value, by fluid temperature in temperature sensor detection constant temperature water tank, if less than minimum value, controller
Control constant temperature water tank heating is until reach desired value；If temperature is higher than specified maximums, control pressure peristaltic pump stops to folder
Injection hot water in layer.
The utility model can be by changing the volume inside silicone tube, stomach and intestine to interlayer cavity supply gas or liquid
The wriggling in road is simulated by the continuous contraction process that squeezes of silicone tube.
The utility model has the following advantages that：
Traditional magnetic stirring apparatus simulated gastrointestinal tract is replaced using the good silicone tube of telescopicing performance in the utility model
Wriggling function, the defects of can overcoming magnetic stirring apparatus that cannot work long hours, and the convergent-divergent process of silicone tube are closer to stomach
The wriggling state of enteron aisle, simulation are more true to nature.
Description of the drawings
Fig. 1 is the utility model human gastrointestinal tract in vitro digestion unit mechanisms schematic diagram.
Wherein, 1 is retort, and 2 be silicone tube, and 3 be interlayer cavity, and 4 be end bindiny mechanism, and 5 be middle part bindiny mechanism,
6 be pressure inlets, and 7 be pressure export, and 8 be material mouth, and 9 be acid ＆ alkali liquid import, and 10 be pH meter mouths.
Specific embodiment
As shown in Figure 1,
A kind of human gastrointestinal tract in vitro digestion device, the in-vitro simulated device of human body alimentary canal include two retort
(1), middle part bindiny mechanism (5), Liang Ge ends bindiny mechanism (4), controller, material peristaltic pump and pressure peristaltic pump；
Include to accommodate the cavity of liquid in the middle part bindiny mechanism (5) and end bindiny mechanism (4)；
Retort (1) both ends open；The retort (1) is internally provided with silicone tube (2), the silicone tube (2)
Both ends are tightly connected respectively with retort (1) both ends, and silicone tube (2) outer wall surrounds independence with the retort (1) inner wall
Interlayer cavity (3), the internal open communication with the retort (1) both ends of the silicone tube (2)；Retort (1) wall
Equipped with pressure inlets (6) and pressure export (7), the pressure inlets (6) connect the interlayer cavity with pressure export (7)
(3)；
The one end open of described two retort (1) is connected by the cavity in the middle part bindiny mechanism (5), and described two
Another opening of a retort (1) is respectively communicated with the cavity of an end bindiny mechanism (4)；
Material mouth (8) is provided on the end bindiny mechanism (4), the material mouth (8) connects the end connection machine
The cavity of structure (4)；
The controller connection controls the material peristaltic pump and the pressure peristaltic pump；The material peristaltic pump connects institute
State material mouth (8)；The pressure peristaltic pump connects the pressure inlets (6) or pressure export (7).
Temperature incubation function can be realized by being passed through constant-current constant-temperatureself-injection water in the interlayer cavity (3).
Further, linker has been provided with outside the in-vitro simulated unit of the human body alimentary canal, the linker connects institute
State pressure inlets (6) or pressure export (7).It can be realized to liquid level in tank by installing contact-free level instrument and linker
Detection, realize the measure to tank intraformational bed cavity (3) volume.
Further, acid ＆ alkali liquid import (9), the acid ＆ alkali liquid are provided at least one end bindiny mechanism (4)
Import (9) connects the cavity of the end bindiny mechanism (4).
Further, pH meter mouth (10) is provided on the middle part bindiny mechanism (5), the pH meter mouth (10) connects institute
State the cavity of middle part bindiny mechanism (5)；PH meter is provided in the pH meter mouth (10), the pH meter connects controller；The control
Device control processed is connected with acid ＆ alkali liquid peristaltic pump, and the acid ＆ alkali liquid peristaltic pump connects the acid ＆ alkali liquid import (9).It is set by controller
Target ph is put, if pH is less than minimum value or maximum value, starts acid ＆ alkali liquid peristaltic pump, towards the interior injection dilution of simulation reaction tank (1)
Lye or acid solution, after reaching desired value, stop acid ＆ alkali liquid peristaltic pump.
Further, the opening at retort (1) both ends is ground, passes through flange and the middle part bindiny mechanism (5)
Or end bindiny mechanism (4) connection.
Further, the both ends of the silicone tube (2) are routed up outside the opening of the retort (1).
Further, the retort (1) is cylindrical tank.
Further, the retort (1) is the glass material of high-temperature-resistant high-pressure-resistant.
Further, the human gastrointestinal tract in vitro digestion device further includes humidity control system, and the temperature is adjusted
System includes sealed constant temperature water tank and temperature sensor；The constant temperature water tank is controlled by the controller, and the controller connects
The temperature sensor is connect, the temperature sensor is set in the constant temperature water tank.Set fluid temperature in constant temperature water tank
Desired value, maximum value, minimum value, by fluid temperature in temperature sensor detection constant temperature water tank, if less than minimum value, controller
Control constant temperature water tank heating is until reach desired value；If temperature is higher than specified maximums, control pressure peristaltic pump stops to folder
Injection hot water in layer.
When the peptic digest process for using the utility model simulation human body, foodstuff samples and stomach simulated digestive juice are passed through into object
Material mouth (8) is packed into retort (1), opens thermostat water bath water filling and enters interlayer cavity (3), silicone tube (2) is by interlayer cavity
(3) interior constant temperature water pressure is shunk, and foodstuff samples enter the other end from retort (1) one end.Adjust interlayer cavity (3)
Interior pressure size, foodstuff samples are moved back and forth out of retort (1) silicone tube (2) cavity, this process realizes the wriggling of stomach
Simulation.It can be inserted into the pH value of pH meter moment monitoring sample in the operating process, in the cavity of middle part bindiny mechanism (5).Pass through
System controller sets target ph, if pH is less than minimum value or maximum value in cavity, starts acid ＆ alkali liquid peristaltic pump, towards simulation
The interior acid ＆ alkali liquid import (9) of retort (1) injects diluted lye or acid solution, after reaching desired value, stops acid ＆ alkali liquid peristaltic pump.
The process also controls interlayer cavity (3) interior water temperature by sealed constant temperature water tank, and then controls the temperature of foodstuff samples, with maximum
Limit simulates human intestines and stomach's channel temp.After foodstuff samples fully react in retort (1) with stomach reaction solution, then stop pressure
Supply, so as to complete the simulation digestion process of stomach.
Claims (8)
1. a kind of human gastrointestinal tract in vitro digestion device, which is characterized in that including two retort, middle part bindiny mechanism, two
A end bindiny mechanism, controller, material peristaltic pump and pressure peristaltic pump；
Include to accommodate the cavity of liquid in the middle part bindiny mechanism and end bindiny mechanism；
The retort both ends open；The retort is internally provided with silicone tube, the silicone tube both ends respectively with retort
Both ends are tightly connected, and the silica gel pipe outer wall surrounds independent interlayer cavity with the top tank structure that reacts, inside the silicone tube
With the open communication at the retort both ends；It is described reaction tank skin be equipped with pressure inlets and pressure export, the pressure inlets and
Pressure export connects the interlayer cavity；
The one end open of described two retort is connected by the cavity in the middle part bindiny mechanism, described two retort
Another, which is open, is respectively communicated with the cavity of an end bindiny mechanism；
Material mouth is provided in the end bindiny mechanism, the material mouth connects the cavity of the end bindiny mechanism；
The controller connection controls the material peristaltic pump and the pressure peristaltic pump；The material peristaltic pump connects the object
Material mouth；The pressure peristaltic pump connects the pressure inlets or pressure export.
2. digester according to claim 1, which is characterized in that be provided with acid at least one end bindiny mechanism
Lye import, the cavity of end bindiny mechanism described in the acid ＆ alkali liquid inlet communication.
3. digester according to claim 1, which is characterized in that pH meter mouth, institute are provided in the middle part bindiny mechanism
State the cavity that pH meter mouth connects the middle part bindiny mechanism；PH meter is provided in the pH meter mouth, the pH meter connects controller；
The controller control is connected with acid ＆ alkali liquid peristaltic pump, and the acid ＆ alkali liquid peristaltic pump connects the acid ＆ alkali liquid import.
4. digester according to claim 1, which is characterized in that the opening at the retort both ends is ground, passes through method
It is blue to be connected with the middle part bindiny mechanism or the end bindiny mechanism.
5. digester according to claim 1, which is characterized in that the both ends of the silicone tube are in the opening of the retort
Place is outer to be routed up.
6. digester according to claim 1, which is characterized in that the retort is cylindrical tank.
7. digester according to claim 1, which is characterized in that the retort is the glass material of high-temperature-resistant high-pressure-resistant
Matter.
8. digester according to claim 1, which is characterized in that the human gastrointestinal tract in vitro digestion device further includes
Humidity control system, the humidity control system include sealed constant temperature water tank and temperature sensor；The constant temperature water tank is by institute
Controller control is stated, the controller connects the temperature sensor, and the temperature sensor is set in the constant temperature water tank.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721146538.9U CN207503515U (en) | 2017-09-08 | 2017-09-08 | A kind of human gastrointestinal tract in vitro digestion device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721146538.9U CN207503515U (en) | 2017-09-08 | 2017-09-08 | A kind of human gastrointestinal tract in vitro digestion device |
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| CN207503515U true CN207503515U (en) | 2018-06-15 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110632963A (en) * | 2019-09-12 | 2019-12-31 | 浙江大学 | Full-automatic program-controlled simulated bionic gastrointestinal digestion device |
| CN110850039A (en) * | 2019-12-10 | 2020-02-28 | 天津开发区合普工贸有限公司 | Dynamic swing type intestinal tract in-vitro substitution experimental device |
| CN112111393A (en) * | 2020-09-28 | 2020-12-22 | 重庆大学 | Bionic intestinal flow self-peristaltic reactor system and method |
-
2017
- 2017-09-08 CN CN201721146538.9U patent/CN207503515U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110632963A (en) * | 2019-09-12 | 2019-12-31 | 浙江大学 | Full-automatic program-controlled simulated bionic gastrointestinal digestion device |
| CN110850039A (en) * | 2019-12-10 | 2020-02-28 | 天津开发区合普工贸有限公司 | Dynamic swing type intestinal tract in-vitro substitution experimental device |
| CN112111393A (en) * | 2020-09-28 | 2020-12-22 | 重庆大学 | Bionic intestinal flow self-peristaltic reactor system and method |
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