CN202128563U - Rodent only-nasal type inhalation toxicity exposure test device - Google Patents
Rodent only-nasal type inhalation toxicity exposure test device Download PDFInfo
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- CN202128563U CN202128563U CN 201120234671 CN201120234671U CN202128563U CN 202128563 U CN202128563 U CN 202128563U CN 201120234671 CN201120234671 CN 201120234671 CN 201120234671 U CN201120234671 U CN 201120234671U CN 202128563 U CN202128563 U CN 202128563U
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Abstract
The utility model provides a rodent only-nasal type inhalation toxicity exposure test device which is characterized in that poisonous substance aerosol generator is controlled by a computer; concentration and flow of the aerosol are controlled by various flow monitors; the aerosol is conveyed to a poisonous gas exposure cavity and then aligns with the nasal part of a test animal fixed in an animal only-nasal fixing frame by using each branch pipe diffusion port to be inhaled; the exhalant waste gas is discharged by side wall discharging holes in the front of sealing nasal rings to a poisonous waste gas collecting cavity and then is conveyed to a waste gas adsorption treatment device by a poisonous waste gas discharging pipe to be treated and discharged safely; the whole set of device is closed; the animal exposure quantity can be increased or reduced randomly; the poisonous aerosol concentration and the oxygen concentration can be controlled manually; and test parameters can be stored and printed. The rodent only-nasal type inhalation toxicity exposure test device has the advantages of small volume and high precision, is safe and environment-friendly, saves the test animals and the poisonous substances, is widely applied in the fields of scientific research such as toxicology, occupational disease prevention, medical treatment and the like, and provides new methods and new test means for inhalation toxicology.
Description
Technical field
This utility model relates to a kind of rodent nose formula toxicity on inhalation and exposes experimental provision.
Background technology
Toxicity on inhalation commonly used exposes experimental provision and is mostly the systemic exposure mode, and the equipment therefor floor space is big, and cost is high; Efficient is low, and specific aim is poor, and the consumption sample size is big; Animal eye, ear, skin contamination influence experiment effect; The contamination medicine possibly licked by animal, is difficult to accomplish local toxicity on inhalation and exposes experiment, has restricted relevant development of scientific research.
The utility model content
For addressing the above problem, the purpose of this utility model provides a kind of rodent nose formula toxicity on inhalation and exposes experimental provision, and volume is little; Efficient is high, and cost is low, saves experiment sample; Do not pollute laboratory animal other positions except that nose, animal can't lick sample, only respiratory system is exposed contamination and does not pollute other positions such as skin; Laboratory facilities are flexible; With strong points, can be widely used in scientific research fields such as toxicity, prophylaxis, medical treatment, for inhalation toxicology provides new method and new laboratory facilities.
For realizing above-mentioned purpose; The technical scheme of this utility model provides a kind of rodent nose formula toxicity on inhalation and exposes experimental provision; Comprising computer-controlled contamination material aerosol generator is delivered to via the aerosol input in the contamination gas exposure chamber of contamination gas sampling intracavity through aerosol flow monitor control aerosol concentration and flow; Again by with each branch pipe diffusing opening over against the nose that is fixed on the laboratory animal in the animal nose fixed mount suck, afterbody is top flat assurance laboratory animal fixed-site fixedly; The sidewall discharge orifice of the waste gas of breathing out before by sealing nose circle is discharged to contamination gas sampling intracavity; Be displaced in the waste gas adsorption treatment device through the contamination exhaust emission tube then, and contamination gas exposes aerosol unnecessary in the chamber and is discharged in the waste gas adsorption treatment device safety dumping after the purified treatment under controlling through being installed in the toxic emission watch-dog that is connected with the air inlet pipe rightabout; This device take can dismounting the design of plug-in type hierarchy, every layer of dismantled and assembled sealing ring that all has conveniently adds installation and dismantling and subtracts the laboratory animal exposed surface; Contamination gas exposes the chamber and the branch pipe diffusing opening is respectively equipped with the fixed mount closed hole and the ferrule circle leaks in order to guarantee that an animal nose fixed mount sealing does not have; Experiment parameter can be stored in the computer or printer prints.
The effect of this utility model is: provide a kind of rodent nose formula toxicity on inhalation to expose experimental provision, volume is little, and efficient is high; Cost is low, saves experiment sample, does not pollute laboratory animal other positions except that nasal portion; Animal can't lick sample, only respiratory system is exposed contamination and does not pollute other positions such as skin, and laboratory facilities are flexible; With strong points, can be widely used in scientific research fields such as toxicity, prophylaxis, medical treatment, for inhalation toxicology provides new method and new laboratory facilities.
Description of drawings
Accompanying drawing 1 is for exposing the contamination sketch map;
Accompanying drawing 2 is contamination gas sampling chamber profile;
Accompanying drawing 3 is contamination gas sampling chamber vertical view;
Accompanying drawing 4 exposes the contamination profile for animal;
Among the figure:
1, compressed air source unit
2, gas flow watch-dog
3, aerosol generator
4, aerosol flow monitor
5, contamination gas sampling chamber
6, an animal nose fixed mount
7, laboratory animal
8, toxic emission watch-dog
9, waste gas adsorption treatment device
10, computer
11, printer
12, dismantled and assembled sealing ring
13, contamination gas exposes the chamber
14, branch pipe diffusing opening
15, contamination exhaust emission tube
16, sealing nose circle
17, sidewall discharge orifice
18, the fixing top flat of afterbody
19, fixed mount closed hole
20, ferrule circle.
The specific embodiment
In conjunction with accompanying drawing and embodiment this utility model is explained.
Shown in accompanying drawing 1, accompanying drawing 2 and accompanying drawing 3 and accompanying drawing 4, this utility model device comprises that compressed air source unit 1 carries gas to the aerosol generator 3 preparation contamination material aerosol systems of firm discharge under the monitoring of gas flow watch-dog 2; Contamination gas in aerosol flow monitor 4 is controlled aerosol concentration and flow volume delivery to the gas sampling chamber 5 of contaminating well exposes in the chamber 13; Expose outwards radial several contamination branch pipe diffusing openings 14 that is equipped with of level one circle on 13 sidewalls of chamber at contamination gas; The laboratory animal 7 that each contamination branch pipe diffusing opening 14 faces animal nose fixed mount 6 internal fixation is carried out a snuffing and is gone into the toxic exposure experiment, and afterbody fixedly top flat 18 guarantees that laboratory animal 7 fixing nothings move; This device take can dismounting the design of plug-in type hierarchy; Each layer all exposes chamber 13, contamination gas sampling chamber 5 and contamination branch pipe diffusing opening 14 by contamination gas and forms the animal layer of independently contaminating; All be can dismounting the plug-in type hierarchy, be used for freely increasing and decreasing the quantity of laboratory animal, each layer can be installed several animals nose fixed mount 6; Adopt sealing ring 12 sealing and fixing between every layer, can dismantle easily and assemble; An animal nose fixed mount 6 be mounted on through fixed mount closed hole 19 on the sidewall in contamination gas sampling chamber 5 and ferrule circle 20 on the contamination branch pipe diffusing opening 14 on the sidewall in contamination gas sampling chamber 5 and with the isolated installation and removal easily of external world's sealing; Thereby concentration and flow that package unit is taken place by the computer controlled automatic aerosol and enter into contamination gas and expose the contamination aerosol concentration of each contamination branch pipe diffusing opening 14 of chamber 13 neutralizations and contamination aerosol concentration and the flow that flow has also just been controlled each laboratory animal nose suction; Unnecessary contamination aerosol is installed in toxic emission watch-dog 8 controls that are connected with the air inlet pipe rightabout in contamination gas exposure chamber 13 and is discharged in the waste gas adsorption treatment device 9, and the waste gas of breathing out through the laboratory animal nose is discharged into contamination gas sampling chamber 5 safety dumping after contamination exhaust emission tube 15 is delivered to waste gas adsorption treatment device 9 purified treatment by sealing nose circle 16 preceding sidewall discharge orifices 17.Whole device sealingly secure does not have leakage, and each item technical parameter of experimentation and experimental result can be stored in the computer 10 or through printer 11 and print.
Embodiment
Using this utility model device to carry out a rodent nose formula toxicity on inhalation when exposing experiment; At first select to install the laboratory animal number of plies according to the required size of animal that experimentizes; And guarantee airtight firm; Put into each animal nose fixed mount 6 to laboratory animal 7 respectively, make the mouth and nose of laboratory animal pass the looping pit of sealing nose circle 16, with the fixing fixing laboratory animal 7 of top flat 18 of afterbody; And each animal nose fixed mount 6 is installed in the ferrule circle 20 on the fixed mount closed hole 19 contamination branch pipe diffusing openings 14 on 5 sidewalls of contamination gas sampling chamber, guarantee laboratory animals and the isolated installation and removal easily of extraneous sealing in the laboratory animal nose fixed mount 6.Open computer 10, compressed air source unit 1, gas flow watch-dog 2, aerosol generator 3, aerosol flow monitor 4 and toxic emission watch-dog 8 and waste gas adsorption treatment device 9 successively; Computer is adjusted gas flow watch-dog 2 according to pre-set ground program and is made with aerosol flow monitor 4 and satisfy requirement of experiment, and contamination material aerosol gets into contamination gas and exposes chamber 13 and be transported to through branch pipe diffusing opening 14 and carry out a snuffing in the animal nose fixed mount 6 and go into the toxic exposure experiment; The sidewall discharge orifices 17 of the waste gas of breathing out before by sealing nose circle 16 are discharged into contamination gas sampling chamber 5 and are delivering to waste gas adsorption treatment device 9 through contamination exhaust emission tube 15, and contamination gas exposes in the chamber 13 unnecessary contamination aerosol to be become waste gas and also deliver to waste gas adsorption treatment device 9 purified treatment safety dumpings in the monitoring of toxic emission watch-dog 8; All experiment parameters and result all can be by computer control, storage or printings in the experimentation.After experiment finishes; Close aerosol generator 8, aerosol flow monitor 4, compressed air source unit 1, gas flow watch-dog 2, toxic emission watch-dog 8 and waste gas adsorption treatment device 9 successively; Pull down an animal nose fixed mount 6, take out the laboratory animal experiment Analysis, finish experiment.
Claims (6)
1. a rodent nose formula toxicity on inhalation exposes experimental provision; It is characterized in that: the contamination material aerosol generator (3) that comprises computer (10) control is delivered to via the aerosol input in the contamination gas exposure chamber (13) in the contamination gas sampling chamber (5) through aerosol flow monitor (4) control aerosol concentration and flow; Again by with each branch pipe diffusing opening (14) over against the nose that is fixed on the laboratory animal (7) in the animal nose fixed mount (6) suck, afterbody is top flat (18) assurance laboratory animal (7) fixed-site fixedly; The waste gas of breathing out is discharged in the contamination gas sampling chamber (5) by the preceding sidewall discharge orifice (17) of sealing nose circle (16); Be displaced in the waste gas adsorption treatment device (9) through contamination exhaust emission tube (15) then, and contamination gas exposes aerosol unnecessary in the chamber (13) and is discharged in the waste gas adsorption treatment device (9) safety dumping after the purified treatment under controlling through being installed in the toxic emission watch-dog (8) that is connected with the air inlet pipe rightabout; This device take can dismounting the design of plug-in type hierarchy, every layer of dismantled and assembled sealing ring (12) that all has conveniently adds installation and dismantling and subtracts the laboratory animal exposed surface; Contamination gas exposes chamber (13) and branch pipe diffusing opening (14) is respectively equipped with fixed mount closed hole (19) and ferrule circle (20) leaks in order to guarantee that animal nose fixed mount (a 6) sealing does not have; Experiment parameter can be stored in the computer (10) or printer (11) is printed.
2. a kind of rodent according to claim 1 nose formula toxicity on inhalation exposes experimental provision; It is characterized in that: expose chamber (13) at described contamination gas and be enclosed in contamination center, gas sampling chamber (5); Expose outwards radial several contamination branch pipe diffusing openings (14) that is equipped with of level one circle on the sidewall of chamber (13) at contamination gas; Each contamination branch pipe diffusing opening (14) faces the nose of the laboratory animal (7) of laboratory animal nose fixed mount (a 6) internal fixation; Contamination gas exposes top, chamber (13) or bottom one end and air inlet pipe is installed is connected to aerosol flow monitor (4) and makes by the contamination gas delivery of control aerosol concentration and flow to the gas of contaminating and expose chamber (13), exposes chamber (13) at contamination gas and the rightabout connection toxic emission watch-dog (8) of air inlet pipe is installed and is connected to waste gas adsorption treatment device (9).
3. a kind of rodent according to claim 1 nose formula toxicity on inhalation exposes experimental provision; It is characterized in that: be enclosed in contamination gas in described contamination gas sampling chamber (5) and expose that chamber (13) is peripheral collects the waste gas that a plurality of sidewall discharge orifices (17) of being provided with from sealing nose circle (16) front side wall of an animal nose fixed mount (6) are discharged, be connected to waste gas adsorption treatment device (9) from the contamination exhaust emission tube (15) that exposes chamber (13) air inlet pipe rightabout one end with contamination gas.
4. a kind of rodent according to claim 1 nose formula toxicity on inhalation exposes experimental provision; It is characterized in that: expose chamber (13), contamination gas sampling chamber (5) and contamination branch pipe diffusing opening (14) at described contamination gas and be designed to the plug-in type hierarchy that conveniently to pull down or to install respectively; Each layer can be installed several animals nose fixed mount (6); Expose chamber (13) cavity at contamination gas respectively between every layer and adopt dismantled and assembled sealing ring (12) sealing and fixing with contamination gas sampling chamber (5) cavity, the contamination gas that laboratory animal that can be different according to experiment needs (7) quantity is installed the different numbers of plies exposes chamber (13) and can carry out a plurality of laboratory animals (7) exposure experiment simultaneously with contaminate the gas sampling chamber (5) and the branch pipe diffusing opening (14) of contaminating.
5. a kind of rodent according to claim 1 nose formula toxicity on inhalation exposes experimental provision; It is characterized in that: a laboratory animal nose fixed mount (6) is mounted on the sidewall in contamination gas sampling chamber (5) through fixed mount closed hole (19) on the sidewall of contamination gas sampling chamber (5) and the ferrule circle (20) on the contamination branch pipe diffusing opening (14), has both guaranteed laboratory animal and the isolated installation and removal easily of extraneous sealing in the laboratory animal nose fixed mount (6).
6. a kind of rodent according to claim 1 nose formula toxicity on inhalation exposes experimental provision; It is characterized in that: described animal nose fixed mount (a 6) front portion is provided with the ring packing nose circle made from flexible material (16), laboratory animal (7) rear portion be provided with afterbody fixedly top flat (18) in order to fixing laboratory animal (7); The nose of laboratory animal (7) leans out from the looping pit of sealing nose circle (16); Be exposed in the contamination branch pipe diffusing opening (14); On the preceding sidewall of the sealing nose circle (16) of an animal nose fixed mount (6), be provided with a plurality of sidewall discharge orifices (17); The waste gas of breathing out in order to discharging is to the gas sampling chamber (5) of contaminating, and other organ beyond laboratory animal (7) nose completely cuts off with contamination branch pipe diffusing opening (14) and contamination gas sampling chamber (5) are inner.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201120234671 CN202128563U (en) | 2011-07-06 | 2011-07-06 | Rodent only-nasal type inhalation toxicity exposure test device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201120234671 CN202128563U (en) | 2011-07-06 | 2011-07-06 | Rodent only-nasal type inhalation toxicity exposure test device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202128563U true CN202128563U (en) | 2012-02-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201120234671 Expired - Lifetime CN202128563U (en) | 2011-07-06 | 2011-07-06 | Rodent only-nasal type inhalation toxicity exposure test device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202128563U (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102389339A (en) * | 2011-07-06 | 2012-03-28 | 天津开发区合普工贸有限公司 | Only-nose inhaling poison exposure experimental equipment for rodent |
| CN102788868A (en) * | 2012-09-04 | 2012-11-21 | 天津开发区合普工贸有限公司 | Whole-body and only-nose compatible breathing toxicity test equipment |
| CN104812301A (en) * | 2012-09-25 | 2015-07-29 | 吸入科学瑞典股份公司 | Exposure system |
| CN106175975A (en) * | 2016-07-11 | 2016-12-07 | 中国环境科学研究院 | A kind of Powder aerosol dynamic formula per os nasal inhalation contamination device |
| CN110251266A (en) * | 2019-06-25 | 2019-09-20 | 中国人民解放军陆军军医大学 | Exposure contamination experiment device is combined in a kind of rat noise and carbon monoxide integration |
| CN113768657A (en) * | 2021-10-12 | 2021-12-10 | 兵器工业卫生研究所 | Gas inhalation contamination experiment exposure device |
-
2011
- 2011-07-06 CN CN 201120234671 patent/CN202128563U/en not_active Expired - Lifetime
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102389339A (en) * | 2011-07-06 | 2012-03-28 | 天津开发区合普工贸有限公司 | Only-nose inhaling poison exposure experimental equipment for rodent |
| CN102788868A (en) * | 2012-09-04 | 2012-11-21 | 天津开发区合普工贸有限公司 | Whole-body and only-nose compatible breathing toxicity test equipment |
| CN104812301A (en) * | 2012-09-25 | 2015-07-29 | 吸入科学瑞典股份公司 | Exposure system |
| CN106175975A (en) * | 2016-07-11 | 2016-12-07 | 中国环境科学研究院 | A kind of Powder aerosol dynamic formula per os nasal inhalation contamination device |
| CN110251266A (en) * | 2019-06-25 | 2019-09-20 | 中国人民解放军陆军军医大学 | Exposure contamination experiment device is combined in a kind of rat noise and carbon monoxide integration |
| CN113768657A (en) * | 2021-10-12 | 2021-12-10 | 兵器工业卫生研究所 | Gas inhalation contamination experiment exposure device |
| CN113768657B (en) * | 2021-10-12 | 2024-05-10 | 兵器工业卫生研究所 | Exposure device for gas inhalation contamination experiment |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee | ||
| CP02 | Change in the address of a patent holder |
Address after: 300110 Tianjin city Nankai District Weishui road win atlas building 2-602 Patentee after: Tianjin Development Zone Hepu Industry and Trade Co., Ltd. Address before: 300020 Xinjiang Road, Heping District, Tianjin, No. 9 Patentee before: Tianjin Development Zone Hepu Industry and Trade Co., Ltd. |
|
| CX01 | Expiry of patent term |
Granted publication date: 20120201 |
|
| CX01 | Expiry of patent term |