CN113768657B - Exposure device for gas inhalation contamination experiment - Google Patents
Exposure device for gas inhalation contamination experiment Download PDFInfo
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- CN113768657B CN113768657B CN202111189991.9A CN202111189991A CN113768657B CN 113768657 B CN113768657 B CN 113768657B CN 202111189991 A CN202111189991 A CN 202111189991A CN 113768657 B CN113768657 B CN 113768657B
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- 238000011109 contamination Methods 0.000 title claims abstract description 27
- 238000002474 experimental method Methods 0.000 title claims abstract description 15
- 239000007789 gas Substances 0.000 claims abstract description 153
- 238000009792 diffusion process Methods 0.000 claims abstract description 14
- 241001465754 Metazoa Species 0.000 claims description 11
- 239000010410 layer Substances 0.000 claims description 10
- 229910000831 Steel Inorganic materials 0.000 claims description 8
- 239000010959 steel Substances 0.000 claims description 8
- 231100000824 inhalation exposure Toxicity 0.000 claims description 6
- 238000005192 partition Methods 0.000 claims description 5
- 239000011521 glass Substances 0.000 claims description 4
- 238000007789 sealing Methods 0.000 claims description 3
- 239000002912 waste gas Substances 0.000 claims description 3
- 239000011229 interlayer Substances 0.000 claims description 2
- 231100000331 toxic Toxicity 0.000 description 6
- 230000002588 toxic effect Effects 0.000 description 5
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 3
- 238000004880 explosion Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 230000004075 alteration Effects 0.000 description 2
- 239000002360 explosive Substances 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- TXKMVPPZCYKFAC-UHFFFAOYSA-N disulfur monoxide Inorganic materials O=S=S TXKMVPPZCYKFAC-UHFFFAOYSA-N 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000004868 gas analysis Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- XTQHKBHJIVJGKJ-UHFFFAOYSA-N sulfur monoxide Chemical compound S=O XTQHKBHJIVJGKJ-UHFFFAOYSA-N 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
- A61D7/04—Devices for anaesthetising animals by gases or vapours; Inhaling devices
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention belongs to the technical field of contamination experiment devices, and particularly relates to a gas inhalation contamination experiment exposure device. The gas cylinder comprises a plurality of gas cylinders, a premixing cavity for receiving the gas in the gas cylinders, a mixing cavity for receiving the gas in the premixing cavity and uniformly mixing the gas, and an exposure box for receiving the gas in the mixing cavity, wherein the outlet of each gas cylinder is provided with a first gas control ball valve and a gas mass flow controller, the gas mass flow controller is connected with the inlet of the premixing cavity, the inlet of the premixing cavity is also provided with a second gas control ball valve, and the outlet of the premixing cavity is connected with the mixing cavity through a third gas control ball valve; the mixing cavity comprises a conveying chamber, a diffusion chamber, a mixing chamber and a collecting chamber which are sequentially communicated and used for uniformly mixing a plurality of gases; the device can uniformly mix various gases in real time, and the mixing proportion can be adjusted at will.
Description
Technical Field
The invention belongs to the technical field of contamination experiment devices, and particularly relates to a gas inhalation contamination experiment exposure device.
Background
Taking explosion as an example, toxic and harmful components such as nitrogen oxide, sulfur oxide, carbon monoxide, carbon dioxide and the like contained in the explosion gas can cause threat to human health in the oxygen deficient environment after the explosion. Limited by safety and experimental materials, laboratory studies on the biotoxicity of explosive gases are relatively few. The current mature inhalation exposure device can perform animal exposure experiments on single-component and simply-composed mixed gas. There is currently no established animal exposure equipment for multi-component gases with dynamically changing ratios between the components.
The animal contamination equipment currently applied to toxic and harmful gas inhalation research mainly comprises a dynamic type contamination device, a static type contamination device and a mixed type contamination device, wherein the dynamic type contamination device is continuously supplemented with external air flow in the animal exposure process, so that the concentration of a tested object is kept unchanged, and the replacement of the air flow can ensure the stability of temperature, humidity and pressure in a contamination cabin. Based on the above advantages, dynamic contamination devices have become the tool of choice for inhalation exposure studies. However, in studying the toxic effects of multicomponent gases on living beings, the inhalation-contaminated devices currently on the market all have the following drawbacks: (1) The conventional inhalation contamination equipment does not have a supporting facility for premixing various gases in real time, needs to premix, pressurize and bottle according to the gas components, and has great difficulty and high risk. (2) The ratio of each component has a large range, the concentration of each component needs to be changed in the animal poisoning process, the toxicity effect of the mixed gas is comprehensively analyzed, and the toxicity of each component in different ratios is difficult to be researched by using bottled premixed gas. (3) The difficulty of researching key components which exert toxic effects in multi-component mixed gas by using traditional dynamic contamination equipment is high. (4) The uniformity of explosive gas plays an important role in animal contamination, and the existing contamination equipment does not have the function of uniform mixing.
Disclosure of Invention
The invention aims to provide a gas inhalation contamination experiment exposure device which solves the technical problems.
The aim of the invention can be achieved by the following scheme:
The gas inhalation exposure device for the contamination experiment comprises a plurality of gas steel cylinders for storing gas, a premixing cavity for receiving the gas in the gas steel cylinders, a mixing cavity for receiving the gas in the premixing cavity and uniformly mixing the gas, and an exposure box for receiving the gas in the mixing cavity.
The mixing chamber comprises a conveying chamber, a diffusion chamber, a mixing chamber and a collecting chamber which are sequentially communicated, wherein the conveying chamber and the mixing chamber are cylindrical, the diameter of the conveying chamber is smaller than that of the mixing chamber, a rotatable axial flow impeller is arranged in the conveying chamber, the diffusion chamber and the collecting chamber are funnel-shaped and are symmetrically arranged by taking the mixing chamber as a center, grid structures are arranged in the diffusion chamber and the collecting chamber, and the grid structures are provided with porous partition walls which are configured to surround a plurality of compartments, and the compartments extend from an inflow end face to an outflow end face to form a gas flow path.
Further, the outlet of each gas steel cylinder is provided with a first gas control ball valve and a gas mass flow controller, the gas mass flow controller is connected with the inlet of the premixing cavity, the inlet of the premixing cavity is further provided with a second gas control ball valve, the outlet of the premixing cavity is connected with the mixing cavity through a third gas control ball valve, and the premixing cavity is further connected with a first gas analyzer.
Further, each gas steel cylinder is provided with a pressure reducing valve.
Further, each of the gas mass flow controllers is connected to the same flow control display.
Still further, axial-flow impeller passes through rotating electrical machines drive, axial-flow impeller is connected with the one end of pivot, the pivot rotate connect in the inner wall of transport room, the other end of pivot is provided with first bevel gear, first bevel gear and second bevel gear meshing, the second bevel gear with rotating electrical machines's output shaft, just rotating electrical machines set up in the outer diapire of transport room.
Still further, the narrow mouth end of collecting the room is connected with the first end of four-way pipe through fourth gas control ball valve, the second end of four-way pipe is connected with the vacuum pump through fifth gas control ball valve, the third end of four-way pipe is connected with the second gas analysis appearance through sixth gas control ball valve, the fourth end of four-way pipe through seventh gas control ball valve with expose the case and be connected.
Still further, expose the case and be double-deck high transparent thickening organic glass box, be equipped with the intermediate layer between the bilayer, the inner layer lateral wall of box evenly is equipped with a plurality of gas pockets, the box top is equipped with the animal business turn over hatch door of taking sealing washer, the outer lateral wall of box still is provided with first gas outlet, second gas outlet and third gas outlet, first gas outlet is connected with exhaust gas treatment system through eighth gas control ball valve, the second gas outlet is connected with the third gas analyzer through ninth gas control ball valve, the third gas outlet is connected with the barometer through tenth gas control ball valve.
Still further, still be provided with singlechip and control panel, all gas control ball valve is the solenoid valve, control panel, rotating electrical machines and all solenoid valves all with the singlechip electricity is connected.
Compared with the prior art, the invention has the following beneficial effects:
1. The flow of each gas is accurately regulated and controlled in real time by using a gas mass flow controller, so that the exposed gases with different mixing ratios are rapidly obtained.
2. The first gas analyzer is arranged in the premixing cavity, so that the concentration of each component of the mixed gas can be monitored in real time, and the exposed gas component and the concentration can be accurately controlled by combining the mass flow controller.
3. The mixing cavity can uniformly mix a plurality of gases, the axial flow impeller is used for primarily dispersing and conveying the gases to the diffusion chamber, the mixing chamber and the collecting chamber, and the gases are further uniformly mixed through the division of the partition walls of the grid structure.
4. The exposure box is made of high-light-transmittance organic glass materials, so that the physiological, behavior and other changes of animals in the contamination process can be conveniently observed, the pressure in the cabin can be adjusted by combining the air outlet with the external pressure gauge of the exposure box, the exposure box is arranged into a double layer, and the inner layer is provided with a plurality of air holes, so that the air can be uniformly released.
5. The toxic effect of different kinds of gases in the mixed components can be purposefully studied.
6. Compared with the currently used main stream inhalation contamination equipment, the device has the advantages of smaller volume, lower cost, simple structure, convenient operation and convenient cleaning.
Drawings
Fig. 1 is a schematic structural view of the present invention.
FIG. 2 is a schematic cross-sectional view of a diffusion chamber of the present invention.
In the figure, 1-gas cylinder, 2-premix chamber, 3-exposure tank, 4-gas mass flow controller, 5-first gas analyzer, 6-delivery chamber, 7-diffusion chamber, 8-mixing chamber, 9-collection chamber, 10-axial flow impeller, 11-vacuum pump, 12-second gas analyzer, 13-flow control display, 14-rotating electric machine, 15-exhaust gas treatment system, 16-third gas analyzer, 17-barometer.
Detailed Description
The present invention will now be described in detail with reference to the drawings and specific examples, which should not be construed as limiting the invention. Unless otherwise indicated, the technical means used in the following examples are conventional means well known to those skilled in the art, and the materials, reagents, etc. used in the following examples are commercially available unless otherwise indicated.
Example 1
Referring to fig. 1-2, a gas inhalation contamination experiment exposure apparatus of the present embodiment includes a plurality of gas cylinders 1 including pressure reducing valves, a premixing chamber 2 for receiving gas in the gas cylinders 1, a mixing chamber for receiving and mixing gas in the premixing chamber 2, and an exposure box 3 for receiving gas in the mixing chamber;
The outlet of each gas steel cylinder 1 is provided with a first gas control ball valve and a gas mass flow controller 4, the gas mass flow controller 4 is connected with the inlet of the premixing cavity 2, the inlet of the premixing cavity 2 is also provided with a second gas control ball valve, the outlet of the premixing cavity 2 is connected with the mixing cavity through a third gas control ball valve, and the premixing cavity is also connected with a first gas analyzer 5;
the mixing cavity comprises a conveying chamber 6, a diffusion chamber 7, a mixing chamber 8 and a collecting chamber 9 which are sequentially communicated, wherein the conveying chamber 6 and the mixing chamber 8 are cylindrical, the diameter of the conveying chamber 6 is smaller than that of the mixing chamber 8, a rotatable axial flow impeller 10 is arranged in the conveying chamber 6, the diffusion chamber 7 and the collecting chamber 9 are funnel-shaped, the two chambers are symmetrically arranged with the mixing chamber 8 as a center, a grid structure is arranged in each of the diffusion chamber 7 and the collecting chamber 9, and the grid structure part is provided with a porous partition wall which is configured to surround a plurality of compartments, and the compartments extend from an inflow end face to an outflow end face to form a gas flow path;
The narrow mouth end of the collecting chamber 9 is connected with the first end of a four-way pipe through a fourth gas control ball valve, the second end of the four-way pipe is connected with a vacuum pump 11 through a fifth gas control ball valve, the third end of the four-way pipe is connected with a second gas analyzer 12 through a sixth gas control ball valve, and the fourth end of the four-way pipe is connected with the exposure box 3 through a seventh gas control ball valve.
In this embodiment, each gas mass flow controller 4 is connected to the same flow control display 13 for monitoring the gas flow.
In this embodiment, the axial flow impeller 10 is driven by the rotating motor 14, the axial flow impeller 10 is connected with one end of the rotating shaft, the rotating shaft is rotationally connected to the inner wall of the conveying chamber, the other end of the rotating shaft is provided with a first bevel gear, the first bevel gear is meshed with a second bevel gear, the second bevel gear is connected with the output shaft of the rotating motor 14, and the rotating motor 14 is arranged on the outer bottom wall of the conveying chamber 6.
In the embodiment, the exposure box 3 is a double-layer high-transparency thickened organic glass box body, an interlayer is arranged between the double layers, and a plurality of air holes are uniformly formed in the side wall of the inner layer of the box body, so that the mixed gas can be uniformly diffused from the periphery of the inner wall of the box body to the middle; the top of the box body is provided with an animal inlet and outlet door with a sealing gasket for animals to enter and exit, the side wall of the outer layer of the box body is also provided with a first air outlet, a second air outlet and a third air outlet, the first air outlet is connected with a waste gas treatment system 15 through an eighth gas control ball valve for treating discharged waste gas, the second air outlet is connected with a third gas analyzer 16 through a ninth gas control ball valve for monitoring the concentration of each component of the mixed gas in real time, and the third air outlet is connected with a barometer 17 through a tenth gas control ball valve for monitoring the pressure of the gas in the cabin in real time.
In this embodiment, a single-chip microcomputer and a control panel are further provided, all the gas control ball valves are electromagnetic valves, the control panel, the rotating motor 14 and all the electromagnetic valves are electrically connected with the single-chip microcomputer, and commands are input in advance according to the required gas quantity, and the single-chip microcomputer automatically controls the opening and closing of the electromagnetic valves and the rotating motor.
According to the exposure device for the gas inhalation contamination experiment, disclosed by the invention, the flow of each gas is accurately regulated and controlled in real time by utilizing the mass flow controller, so that the exposure gases with different mixing ratios are rapidly obtained, the concentration of each component of the mixed gas can be monitored in real time by arranging the first gas analyzer 5 in the premixing cavity 2, and the components and the concentration of the exposure gases are accurately controlled by combining the mass flow controller 4. By arranging the mixing cavity, the input mixed gas is primarily dispersed by the axial flow impeller 10, and the gas is conveyed to the diffusion chamber 7, the mixing chamber 8 and the collecting chamber 9, and is further uniformly mixed by dividing the gas by the partition walls of the grid structure, so that the gas is uniformly exposed.
While preferred embodiments of the present invention have been described, additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. It is therefore intended that the following claims be interpreted as including the preferred embodiments and all such alterations and modifications as fall within the scope of the invention.
It will be apparent to those skilled in the art that various modifications and variations can be made to the present invention without departing from the spirit or scope of the invention. Thus, it is intended that the present invention also include such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Claims (7)
1. The utility model provides a gaseous inhalation contamination experiment exposure device, includes a plurality of gas steel bottle (1) of storing gas, is used for receiving gas in gas steel bottle (1) mixes chamber (2) in advance, is used for receiving gas in premixing chamber (2) and make gaseous mixing's mixing chamber and be used for receiving gaseous exposure case (3) in the mixing chamber, its characterized in that:
The mixing cavity comprises a conveying chamber (6), a diffusion chamber (7), a mixing chamber (8) and a collecting chamber (9) which are sequentially communicated, wherein the conveying chamber (6) and the mixing chamber (8) are cylindrical, the diameter of the conveying chamber (6) is smaller than that of the mixing chamber (8), a rotatable axial flow impeller (10) is arranged in the conveying chamber (6), the diffusion chamber (7) and the collecting chamber (9) are funnel-shaped, the two chambers are symmetrically arranged by taking the mixing chamber (8) as a center, grid structures are arranged in the diffusion chamber (7) and the collecting chamber (9), and the grid structures are provided with porous partition walls which are configured to surround a plurality of compartments, and the compartments extend from an inflow end face to an outflow end face to form a gas flow path;
the outlet of each gas steel bottle (1) is provided with a first gas control ball valve and a gas mass flow controller (4), the gas mass flow controller (4) is connected with the inlet of the premixing cavity (2), the inlet of the premixing cavity (2) is further provided with a second gas control ball valve, the outlet of the premixing cavity (2) is connected with the mixing cavity through a third gas control ball valve, and the premixing cavity is further connected with a first gas analyzer (5).
2. A gas inhalation exposure device according to claim 1, characterized in that a pressure reducing valve is provided on each gas cylinder (1).
3. A gas inhalation exposure device according to claim 2 characterised in that each of the gas mass flow controllers (4) is connected to the same flow control display (13).
4. A gas inhalation exposure device according to claim 3 characterised in that the axial flow impeller (10) is driven by a rotating motor (14), the axial flow impeller (10) is connected with one end of a rotating shaft, the rotating shaft is rotatably connected to the inner wall of the conveying chamber, the other end of the rotating shaft is provided with a first bevel gear which is meshed with a second bevel gear which is connected with the output shaft of the rotating motor (14), and the rotating motor (14) is arranged on the outer bottom wall of the conveying chamber (6).
5. The exposure device for gas inhalation contamination experiment according to claim 4, wherein the narrow mouth end of the collecting chamber (9) is connected with the first end of a four-way pipe through a fourth gas control ball valve, the second end of the four-way pipe is connected with a vacuum pump (11) through a fifth gas control ball valve, the third end of the four-way pipe is connected with a second gas analyzer (12) through a sixth gas control ball valve, and the fourth end of the four-way pipe is connected with the exposure box (3) through a seventh gas control ball valve.
6. The exposure device for the gas inhalation contamination experiment according to claim 5, wherein the exposure box (3) is a double-layer high-transparency thickened organic glass box body, an interlayer is arranged between the double layers, a plurality of air holes are uniformly formed in the inner side wall of the box body, an animal inlet and outlet door with a sealing gasket is arranged at the top of the box body, a first air outlet, a second air outlet and a third air outlet are further formed in the outer side wall of the box body, the first air outlet is connected with the waste gas treatment system (15) through an eighth gas control ball valve, the second air outlet is connected with a third gas analyzer (16) through a ninth gas control ball valve, and the third air outlet is connected with the barometer (17) through a tenth gas control ball valve.
7. The exposure device for gas inhalation contamination experiment according to claim 6, further comprising a single chip microcomputer and a control panel, wherein all the gas control ball valves are solenoid valves, and the control panel, the rotating motor (14) and all the solenoid valves are electrically connected with the single chip microcomputer.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111189991.9A CN113768657B (en) | 2021-10-12 | 2021-10-12 | Exposure device for gas inhalation contamination experiment |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111189991.9A CN113768657B (en) | 2021-10-12 | 2021-10-12 | Exposure device for gas inhalation contamination experiment |
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| CN113768657A CN113768657A (en) | 2021-12-10 |
| CN113768657B true CN113768657B (en) | 2024-05-10 |
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| CN102191177A (en) * | 2011-03-28 | 2011-09-21 | 天津开发区合普工贸有限公司 | Cell radon exposure experimental device |
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| CN102389339A (en) * | 2011-07-06 | 2012-03-28 | 天津开发区合普工贸有限公司 | Only-nose inhaling poison exposure experimental equipment for rodent |
| CN105974053A (en) * | 2015-10-29 | 2016-09-28 | 兵器工业卫生研究所 | Armoured vehicle cabin harmful gas simulation experiment system |
| CN106175975A (en) * | 2016-07-11 | 2016-12-07 | 中国环境科学研究院 | A kind of Powder aerosol dynamic formula per os nasal inhalation contamination device |
| CN216908248U (en) * | 2021-10-12 | 2022-07-08 | 兵器工业卫生研究所 | Multicomponent gas inhales contamination experiment and exposes device |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20040216737A1 (en) * | 2001-07-26 | 2004-11-04 | Anderson Leslie B. | System for anesthetizing laboratory animals |
| CN101842127B (en) * | 2007-06-28 | 2013-01-02 | 吸入科学瑞典股份公司 | Exposure system |
| US11027086B2 (en) * | 2016-02-07 | 2021-06-08 | The Government Of The United States As Represented By The Secretary Of The Army | Oro-nasal inhalation plethysmography mask exposure system |
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2021
- 2021-10-12 CN CN202111189991.9A patent/CN113768657B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102191177A (en) * | 2011-03-28 | 2011-09-21 | 天津开发区合普工贸有限公司 | Cell radon exposure experimental device |
| CN202128563U (en) * | 2011-07-06 | 2012-02-01 | 天津开发区合普工贸有限公司 | Rodent only-nasal type inhalation toxicity exposure test device |
| CN102389339A (en) * | 2011-07-06 | 2012-03-28 | 天津开发区合普工贸有限公司 | Only-nose inhaling poison exposure experimental equipment for rodent |
| CN105974053A (en) * | 2015-10-29 | 2016-09-28 | 兵器工业卫生研究所 | Armoured vehicle cabin harmful gas simulation experiment system |
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