CN203432981U - Multi-concentration animal oral-nasal inhalation dynamic exposure equipment - Google Patents
Multi-concentration animal oral-nasal inhalation dynamic exposure equipment Download PDFInfo
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- CN203432981U CN203432981U CN201320491797.0U CN201320491797U CN203432981U CN 203432981 U CN203432981 U CN 203432981U CN 201320491797 U CN201320491797 U CN 201320491797U CN 203432981 U CN203432981 U CN 203432981U
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Abstract
The utility model discloses a multi-concentration animal oral-nasal inhalation dynamic exposure equipment which comprises an air compressor, an aerosol generation system, an oral-nasal exposure unit and a waste gas recovery treatment system, wherein the oral-nasal exposure unit comprises an experiment group exposure chamber; the aerosol generation system is connected with an aerosol inlet of the experiment group exposure chamber; a waste gas outlet of the experiment group exposure chamber is connected with the waste gas recovery treatment system; the equipment also comprises a multi-concentration dilution system; the experiment group exposure chamber comprises multiple sections of experiment exposure chambers; and the multi-concentration dilution system comprises a second aerosol diluter arranged among the sections of experiment exposure chambers and a third air flow controller for controlling the air inflow in the second aerosol diluter. The second aerosol diluter is arranged among the sections of experiment exposure chambers and used for diluting the aerosol entering the second section of experiment exposure chamber from the first section of experiment exposure chamber so as to meet the experiment requirements and perform experiment comparison in different concentration conditions.
Description
Technical field
The utility model relates to animal and sucks toxicological experiment field, particularly relates to a kind of many concentration animal mouth and nose and sucks dynamic exposure device.Can be used for sucking that toxicity drug safety is evaluated, agricultural chemicals acute toxicity sucks experimental study, build animal COPD various diseases model and its curative effect of medication experimental study, atmosphere pollution is to the research of animal breath systematic influence etc.
Background technology
At present, be to suck in the various scientific researches that toxicity is relevant, the more particularly research to human health objectionable impurities, as PM2.5 etc., owing to can not directly or can not first the mankind being tested, so often will use animal used as test to suck Exposure Assessment.Therefore, animal exposing device has a wide range of applications in industry, agricultural, medical science, environmental pollution and military science research.Complete a kind of EXPERIMENT STUDY ON SUBCHRONIC or evaluation of material, generally need to carry out the animal exposure test of a plurality of dosage.Animal exposing device of the prior art is all single concentration, it is the animal exposure that single test can only be carried out a dosage group, carry out the animal exposure test of a plurality of dosage groups, need to utilize many cover animal exposing devices or just can complete by many experiments with a covering device, can not realize and in same set of suction exposing device, carry out the zoopery of many concentration and comparative analysis simultaneously.
Therefore exist following not enough: can not be simultaneously in prior art at same experimental facilities with carry out animal suck toxicological experiment under multiple concentration.
Utility model content
The object of the utility model embodiment is to provide a kind of many concentration animal mouth and nose and sucks dynamic exposure device, solved in prior art can not be simultaneously at same experimental facilities with carry out the problem that animal sucks toxicological experiment under multiple concentration.
To achieve these goals, the utility model provides a kind of many concentration animal mouth and nose to suck dynamic exposure device, comprises for compressed-air actuated air compressor, gasoloid generation systems, mouth and nose exposure unit and waste gas reclamation treatment system are provided; Described mouth and nose exposure unit comprises experimental group exposure chamber and fixing device for experimental animal; Described gasoloid generation systems comprises aerosol generator, for controlling the first air flow controller of the air inlet amount of described aerosol generator, for providing the medicinal liquid bottle of liquid, the first aerosol diluter being connected with the gasoloid outlet of described aerosol generator to described aerosol generator and for controlling the second air flow controller of the air inlet amount of described the first aerosol diluter; Described the first aerosol diluter is connected with the gasoloid import of described experimental group exposure chamber; The waste gas outlet of described experimental group exposure chamber is connected with described waste gas reclamation treatment system; Wherein,
Also comprise many concentration dilutions system; Described experimental group exposure chamber comprises more piece experiment exposure chamber; Many concentration dilutions system comprises the 3rd air flow controller that is arranged on the second aerosol diluter of respectively saving between described experiment exposure chamber and controls the air inlet amount in the second aerosol diluter.
Preferably, described waste gas reclamation treatment system comprises in turn connected waste gas collection box, device for drying and filtering, exhaust gas flow controller, manual ball valve, vacuum pump and high altitude discharge disposal system); Described waste gas collection box is connected with described waste gas outlet.
Preferably, described mouth and nose exposure unit also comprises oxygen concentration sensor, pressure transducer, temperature sensor and humidity sensor and sampling of aerosol pipe, and described oxygen concentration sensor, described pressure transducer, described temperature sensor, described humidity sensor and described sampling of aerosol pipe are arranged on and respectively save in described experiment exposure chamber.
Preferably, also comprise the micro-negative pressure disposal system of security mask cabinet and vacuum;
Described security mask cabinet comprises animal behavior remote monitoring camera, illuminating lamp, ultraviolet disinfection lamp, USB communication interface and for gathering the thief hatch of gasoloid sample;
The micro-negative pressure disposal system of described vacuum is for preventing that the gasoloid of a small amount of leakage in described security mask cabinet from entering atmosphere, and the micro-negative pressure disposal system of described vacuum comprises retaining valve, differential pressure indicator and vacuum pump.
Preferably, also comprise sampling system and control system.
Preferably, described sampling system comprises two-position two-way solenoid valve, aerosol concentration monitor and gasoloid flow controller and the vacuum pump being connected successively; Described two-position two-way solenoid valve is connected with described sampling of aerosol pipe.
Preferably, described control system comprises industrial PC, touch screen computer, software programming control terminal, data collecting card, Control plate, contactor and RS485 communication interface;
Described contactor, described Control plate, described data collecting card are connected successively with described industrial PC, described RS485 communication interface connects described industrial PC, described software programming control terminal connects described industrial PC, and described touch screen computer connects described industrial PC.
Preferably, described mouth and nose exposure unit also comprises control group exposure chamber.
Preferably, described more piece experiment exposure chamber is three joint experiment exposure chamber or four joint experiment exposure chamber or five joint experiment exposure chamber.
Preferably, in described gasoloid inflow point, described the second aerosol diluter is set.
At least there is following technique effect in the utility model embodiment:
1) by being arranged on the second aerosol diluter respectively saving between described experiment exposure chamber and the 3rd air flow controller of controlling the air inlet amount in the second aerosol diluter, to entered into second section experiment exposure indoor aerosols by first segment experiment exposure chamber, dilute, to meet the requirement of experiment, be also convenient to the contrast of testing under variable concentrations.
2), by sampling system and control system are set, improve automaticity and the control accuracy of this equipment.
3) by the micro-negative pressure disposal system of waste gas reclamation treatment system and security mask cabinet and vacuum is set, can prevent poison gas leakage, exempted the pollution to operating personnel, improved the precision of security and contamination.
4) gasoloid producing from aerosol generator can be simultaneously for a plurality of experiments, and use continuously, save gasoloid use amount, improve aerocolloidal utilization rate.
5) use gasoloid that aerosol generator produces simultaneously for a plurality of experiments, prevent from using a plurality of aerosol generators in traditional many concentration experiments and the systematic error that produces is larger, equipment is complicated, bulky etc.
6) carry out a plurality of experiments, conventional efficient is high simultaneously, and the time is short.
According to the detailed description to the utility model specific embodiment by reference to the accompanying drawings below, those skilled in the art will understand above-mentioned and other objects, advantage and feature of the present utility model more.
Accompanying drawing explanation
Hereinafter in exemplary and nonrestrictive mode, describe specific embodiments more of the present utility model in detail with reference to the accompanying drawings.In accompanying drawing, identical Reference numeral has indicated same or similar parts or part.It should be appreciated by those skilled in the art that these accompanying drawings may not draw in proportion.In accompanying drawing:
Fig. 1 is the structural representation of the utility model embodiment;
Fig. 2 is the detailed structure schematic diagram of the utility model embodiment;
Fig. 3 is the cut-open view of the mouth and nose exposure unit of the utility model embodiment;
Fig. 4 is the structural representation of the second aerosol diluter of the utility model embodiment;
Fig. 5 is the cut-open view of the another kind of mouth and nose exposure unit of the utility model embodiment;
Fig. 6 is the structural representation of another kind the second aerosol diluter of the utility model embodiment;
Reference numeral: air compressor 111, gasoloid generation systems 1, air flow control valve 19, aerosol generator 11, the first aerosol diluter 12, medicinal liquid bottle 13, the first air flow controller 17, the second air flow controller 16, control system 2, industrial PC 21, touch screen computer 22, software programming control terminal 23, data collecting card 24, Control plate 25, contactor 26, RS485 communication interface 27, sampling system 3, two-position two-way solenoid valve 31, aerosol concentration monitor 32, gasoloid flow controller 35, the micro-negative pressure disposal system 5 of vacuum, retaining valve 51, differential pressure indicator 52, mouth and nose exposure unit 6, control group exposure chamber 61, fixing device for experimental animal 62, experimental group exposure chamber 63, first segment experiment exposure chamber 110, second section experiment exposure chamber 120, the 3rd joint experiment exposure chamber 130, inner core 101, urceolus 102, gasoloid import 112, pore 631, connecting pipe 65, the 4th air flow controller 68, many concentration dilutions system 7, Dilution air device 71, the 3rd air flow controller 72, the second aerosol diluter 73, gas the first air intake opening 41, gas inlet pipe 42, venthole 43, the first gas-static chamber 44, static pressure chamber outlet 45, front piece 46, middle part member 47, back member 48, the first material import 401, gas feed 402, the second material import 403, the second gas-static chamber 405, mix induction tunnel 406, hybrid chamber 407, compounding substances escape hole 408, security mask cabinet 8, animal behavior remote monitoring camera 81, illuminating lamp 82, ultraviolet disinfection lamp 83, USB communication interface 84, thief hatch 85, waste gas reclamation treatment system 9, waste gas collection box 91, device for drying and filtering 92, exhaust gas flow controller 93, manual ball valve 94, high altitude discharge disposal system 96.
Embodiment
For making object, technical scheme and the advantage of the utility model embodiment clearer, below in conjunction with accompanying drawing, specific embodiment is described in detail.
As depicted in figs. 1 and 2, many concentration animal mouth and nose suck dynamic exposure device, comprise for compressed-air actuated air compressor 111, gasoloid generation systems 1, mouth and nose exposure unit 6 and waste gas reclamation treatment system 9 are provided; In the exit of air compressor 111, be provided with air flow control valve 19; Mouth and nose exposure unit 6 comprises experimental group exposure chamber 63 and fixing device for experimental animal 62; Gasoloid generation systems 1 comprises aerosol generator 11, for controlling the first air flow controller 17 of the air inlet amount of aerosol generator 11, for providing the medicinal liquid bottle 13 of liquid, the first aerosol diluter 12 being connected with the gasoloid outlet of aerosol generator 11 to aerosol generator 11 and for controlling the second air flow controller 16 of the air inlet amount of the first aerosol diluter 12; The first aerosol diluter 12 is connected with the gasoloid import 112 of experimental group exposure chamber 63; The waste gas outlet of experimental group exposure chamber 63 is connected with waste gas reclamation treatment system 9; Wherein, also comprise many concentration dilutions system 7; Experimental group exposure chamber 63 comprises more piece experiment exposure chamber, as experimental group exposure chamber 63 comprises three joint experiment exposure chamber, is respectively first segment experiment exposure chamber 110, second section experiment exposure chamber 120 and the 3rd joint experiment exposure chamber 130; Also can comprise four joint experiment exposure chamber or five joint experiment exposure chamber.Many concentration dilutions system 7 comprises the 3rd air flow controller 72 that is arranged on the second aerosol diluter 73 between each joint experiment exposure chamber and controls the air inlet amount in the second aerosol diluter 73, as the second aerosol diluter 73 being set between first segment experiment exposure chamber 110 and second section experiment exposure chamber 120, between second section experiment exposure chamber 120 and the 3rd joint experiment exposure chamber 130, the second aerosol diluter 73 is set, the inflow point that also can test exposure chamber 110 at first segment arranges the second aerosol diluter 73.Fixing device for experimental animal 62 is installed the periphery of each joint experiment exposure chamber, animal is arranged in fixing device for experimental animal 62, the gasoloid absorbing in exposure chamber by connecting pipe 65, the waste gas of generation and the unnecessary gasoloid being inhaled into are reclaimed and process by waste gas reclamation treatment system 9.
Exposure chamber comprises inner core 101 and urceolus 102; The first end of inner core 101 is provided with gasoloid import 112, and the second end sealing of inner core 101, in order to be convenient to clean after testing, is provided with aperture in the second bottom portion of inner core 101, during experiment, with plug, stops up, and makes the second end sealing of inner core 101; The first end sealing of urceolus 102, the second end of urceolus 102 is provided with waste gas outlet, and waste gas outlet is a plurality of air holes; On inner core 101, be provided with the connecting pipe 65 being connected with fixing device for experimental animal 62; Urceolus 102 is connected with fixing device for experimental animal 62, can be connected by respiratory siphon being set at animal mouth and nose place, or be connected with the gap that the mouth wall place of fixator connector arranges at connecting pipe 65.Exposure chamber comprises experimental group exposure chamber 63 and control group exposure chamber 61.
In visible the utility model embodiment, air compressor 111 produce first via pressurized air enter into aerosol generator 11, liquid enters into aerosol generator 11 from medicinal liquid bottle 13, and to maintain the liquid level of aerosol generator 11 the insides constant, thereby produce high concentration and the good gasoloid of stability of concentration, below aerosol particle 5 μ m, reach 98, enter into the first aerosol diluter 12, after the second road pressurized air mixed diluting producing with the air compressor 111 entering through the second air flow controller 16 afterwards, from gasoloid import 112, enter into the inner core of the first segment experiment exposure chamber 110 of experimental group exposure chamber 63, gasoloid is diluted to the concentration that needs contamination, can guarantee that under these circumstances animal used as test can better carry out toxicological experiment, part gasoloid is arranged on first segment and tests after the rear discharge of animal absorption in the fixing device for experimental animal 62 of exposure chamber 110 peripheries, from fixing device for experimental animal 62, enter in the urceolus 102 of experimental group exposure chamber 63, the waste gas outlet that the second end of process urceolus 102 arranges, enter into waste gas reclamation treatment system 9, another part gasoloid in first segment experiment exposure chamber 110 enters into the inner core of second section experiment exposure chamber 120 after being arranged on the second aerosol diluter 73 dilutions between each joint experiment exposure chamber, the Third Road pressurized air that air compressor 111 produces enters into the second aerosol diluter 73 for diluting the gasoloid that will enter into second section experiment exposure chamber 120 through controlling the 3rd air flow controller 72 of the air inlet amount in the second aerosol diluter 73, a part of gasoloid in second section experiment exposure chamber 120 is arranged on second section and tests after the rear discharge of animal absorption in the fixing device for experimental animal 62 of exposure chamber 120 peripheries, from fixing device for experimental animal 62, enter in the urceolus 102 of experimental group exposure chamber 63, the waste gas outlet that the second end of process urceolus 102 arranges, enter into waste gas reclamation treatment system 9.Through same mode, another part gasoloid in second section experiment exposure chamber 120 enters into the 3rd joint experiment exposure chamber 130.
Therefore the animal that, the utility model embodiment can realize under variable concentrations in same equipment sucks toxicological experiment.Can realize realizing in many concentration situation simultaneously animal is tested and comparative analysis.
Simultaneously, mouth and nose exposure unit 6 also comprises control group exposure chamber 61, the object that control group is set be can realize with normal growth condition under animal contrast, air compressor 111 produces tetra-road pressurized air and enters into control group exposure chamber 61 through the 4th air flow controller 68, the air that animal absorbs in the exposure chamber of check plot by connecting pipe 65, the waste gas of generation and the unnecessary air being inhaled into are reclaimed and process by waste gas reclamation treatment system 9.
Waste gas reclamation treatment system 9 comprises in turn connected waste gas collection box 91, device for drying and filtering 92, exhaust gas flow controller 93, manual ball valve 94, vacuum pump and high altitude discharge disposal system 96.Waste gas collection box 91 is for reclaiming waste gas, is connected with the waste gas outlet of the second end setting of the urceolus 102 of exposure chamber.In the present embodiment, waste gas reclamation treatment system 9 is two, is respectively used to process the waste gas in experimental group exposure chamber 63 and control group exposure chamber 61.
Mouth and nose exposure unit 6 also comprises oxygen concentration sensor, pressure transducer, temperature sensor and humidity sensor and sampling of aerosol pipe, be arranged in each joint experiment exposure chamber, for detection of oxygen concentration, pressure, temperature and humidity and the aerosol concentration in each joint experiment exposure chamber.
In another one embodiment of the present utility model, many concentration animal mouth and nose suck dynamic exposure device and also comprise security mask cabinet 8 and the micro-negative pressure disposal system 5 of vacuum.Security mask cabinet 8 comprises animal behavior remote monitoring camera 81, illuminating lamp 82, ultraviolet disinfection lamp 83, USB communication interface 84 and for gathering the thief hatch 85 of gasoloid sample.The micro-negative pressure disposal system 5 of vacuum enters atmosphere for preventing the gasoloid of a small amount of leakage in security mask cabinet 8; The micro-negative pressure disposal system 5 of vacuum comprises retaining valve 51, differential pressure indicator 52 and vacuum pump.
In another one embodiment of the present utility model, many concentration animal mouth and nose suck dynamic exposure device and also comprise sampling system 3 and control system 2.
Control system 2 comprises industrial PC 21, touch screen computer 22, software programming control terminal 23, data collecting card 24, Control plate 25, contactor 26 and RS485 communication interface 27; Be used for collecting various parameters, and according to each component working in these parameter opertaing devices, and control and respectively save aerocolloidal concentration in exposure chamber, make equipment meet the requirement of experiment.
On data collecting card 24, connect industrial PC 21, under succeed appliance controling plate 25, Control plate 25 connects contactors 26, contactor 26 is for controlling the unlatching of all vacuum pumps and air compressor 111 or cutting out.Oxygen concentration sensor, pressure transducer, temperature sensor and humidity sensor are connected with data collecting card 24.The first air flow controller 17, the second air flow controller 16, the 3rd air flow controller 72, the 4th air flow controller 68, exhaust gas flow controller 93, gasoloid flow controller 35 are all being connected RS485 communication interface 27 with two-position two-way solenoid valve 31, RS485 communication interface 27 is connecting industrial PC 21, by software programming control terminal 23, to each control hardware terminal coding and send the corresponding command, guaranteed the precision of experiment.Have automation control system, automaticity is high, and experimental precision is high.
During use, first with 83 pairs of security mask cabinets of ultraviolet disinfecting 8, carry out thorough disinfection, to test liquid places in medicinal liquid bottle 13,2 pairs of experiment parameters of opening control arrange, comprise medicinal liquid flow, the first air mass flow, the second air mass flow, the 3rd air mass flow, the 4th air mass flow, exhaust gas flow, gasoloid flow and negative pressure value etc., after setting completed animal used as test is put into fixing device for experimental animal 62, open the micro-negative pressure disposal system 5 of vacuum, the start button order contamination of then clicking in industrial PC 21 starts.Gasoloid generates and enters experimental group exposure chamber 63 by gasoloid generation systems 1.Control group exposure chamber 61 will pass into a certain amount of pressurized air with pass into aerocolloidal experimental group exposure chamber 63 and carry out real-time sampling contrast.Gasoloid in each joint experiment exposure chamber in 3 pairs of experimental group exposure chamber 63 of sampling system is sampled and is obtained aerocolloidal concentration and feeds back to control system 2.Oxygen concentration sensor in each joint experiment exposure chamber, the information that pressure transducer, temperature sensor and humidity sensor collect feeds back to control system 2 constantly.Control system 2 regulates the air capacity entering in this joint experiment exposure chamber according to oxygen concentration, pressure, temperature and humidity and aerosol concentration in each joint experiment exposure chamber.Waste gas in experiment can filter and discharge through waste gas reclamation treatment system 9.Test when complete, industrial PC 21 can generate experimental diagrams, for client, analyzes.The unlatching of whole process, control and operation regulation and control all can complete in software programming control terminal 23, realize full-automatic monitoring and operation, make experiment more easy to operate, safety.Many concentration animal mouth and nose suck dynamic exposure device generated meet the gasoloid of grain size and concentration and concentration can the every one deck in each joint of experimental group exposure chamber 63 be uniformly distributed, under many concentration dilutions system 7 auxiliary, the aerosol concentration of every one deck is different.Full-automation is monitored and is controlled, has waste gas reclamation treatment system 9; Can prevent that poison gas from revealing, can carry out mouth and nose sampling, multi-functional powerful many concentration in time and suck dynamic exposure device.Simple to operate, exempted the pollution to operating personnel, improved the precision of security and contamination.
According to the utility model, in another embodiment of the present utility model, as shown in Figure 3, mouth and nose exposure unit 6 also comprises exposure unit base.The second aerosol diluter 73 is arranged in inner core 101; Waste gas outlet is connected with waste gas reclamation treatment system 9 by being arranged on pore 631 on exposure unit base; Sampling of aerosol pipe is arranged on inner core 101, and gas inlet pipe is also set on inner core 101.Gas inlet pipe, for pass into air in the second aerosol diluter 73, dilutes gasoloid, is provided with the 3rd air flow controller 72 and Dilution air device 71 on gas inlet pipe.
First segment experiment exposure chamber 110, on the urceolus of second section experiment exposure chamber 120 and the 3rd joint experiment exposure chamber 130, be provided with 12 settings fixing device for experimental animal 62 at grade, by first segment, test the second aerosol diluter 73 arranging between the connecting pipe place of inner core of exposure chamber 110 and the connecting pipe place of the inner core of second section experiment exposure chamber 120, the aerocolloidal concentration even circumferential at connecting pipe 65 places that makes to enter into the inner core of second section experiment exposure chamber 120 distributes, at the mouth place of connecting pipe 65, aerocolloidal concentration is the same, the concentration of the same circumferential location of the every one deck in this joint exposure chamber is consistent, can guarantee that the concentration that each animal is drawn in mouth and nose is consistent, aerocolloidal concentration in each joint experiment exposure chamber is the same, only have the concentration of the second aerosol diluter front and back different, the aerocolloidal concentration in each joint experiment exposure chamber is inconsistent, as a part of gasoloid in the gasoloid in first segment experiment exposure chamber is absorbed by animal, remaining gasoloid continues to flow downward, and enters in second section experiment exposure chamber after the second aerosol diluter.By changing the ratio of gasoloid and diluents, can obtain different dilute concentrations.Following table be depicted as these many concentration animal mouth and nose suck the CONCENTRATION DISTRIBUTION in every joint exposure chamber of dynamic exposure device by regulating certain diluting gas flow to obtain (unit: every cubic metre of milligram):
| Interface | 1 | 2 | 3 | 4 | 5 | 6 |
| First segment | 4950 | 4930 | 4870 | 4860 | 5100 | 5090 |
| Second section | 985 | 993 | 971 | 985 | 1021 | 1012 |
| The 3rd joint | 197 | 201 | 197 | 195 | 196 | 187 |
| Interface | 7 | 8 | 9 | 10 | 11 | 12 |
| First segment | 5060 | 4930 | 4970 | 4780 | 4860 | 4920 |
| Second section | 987 | 1020 | 978 | 975 | 983 | 987 |
| The 3rd joint | 193 | 189 | 205 | 196 | 203 | 207 |
As seen from the above table, the dilution effect that these many concentration animal mouth and nose suck dynamic exposure device is relatively good, and the aerosol concentration in the every joint exposure chamber after dilution is more even, is convenient to carry out contrast experiment.
As shown in Figure 4, a kind of the second aerosol diluter 73 comprises mixing induction tunnel 406 and hybrid chamber 407, and the first end that mixes induction tunnel 406 is the first material import 401, and the second end that mixes induction tunnel 406 is connected with hybrid chamber 407; Wherein, also comprise that the second material import 403, the second material imports 403 are for being arranged on the gap on the tube wall that mixes induction tunnel 406, gap is formed by the first surface being parallel to each other and second.First surface is circular conical surface, and circular conical surface is with to mix induction tunnel 406 coaxial.Gap tilts towards the direction of hybrid chamber 407 on the flow direction of the second material.Hybrid chamber 407 comprises the first end cone-shaped cavity being connected with mixing induction tunnel 406, cylindricality cavity and the second end toper cavity of interlude, and the end of the second end toper cavity offers compounding substances escape hole 408.The first material is gasoloid, and the second material is air.By slot-shaped gas-solvent import is set, make air inlet more even, more stable, dilution effect is better.By the direction of the second material import is set, make the differential pressure action at two ends, gap, gas-solvent is entered in hybrid chamber, this kind of setting can prevent that the first material or the second material from flowing backwards, and affects dilution efficiency.By the thin hybrid chamber in thick two in the middle of arranging, in hybrid chamber, form eddy current, further make to mix more even.The width in gap is adjustable, and the width adjusting scope in gap is 0-6mm.Particularly, mix induction tunnel 406 and be divided into first and second portion by gap, between first and second portion, be threaded connection.By the adjustable of gap width is set, regulate the second material inlet, be convenient to be applied to multiple occasion, multiple dilute concentration.Also can regulate needed dilute concentration by controlling air input or gasoloid input quantity.Through a large amount of experimental verification and digital simulation analysis, the effect of the width in gap between 0-6mm is best, if be greater than 6mm, effect is poor.Also comprise that on 405, the second gas-static chambeies 405, the second gas-static chamber, being provided with gas feed 402, the second gas-static chambeies 405 is connected with mixing induction tunnel 406 by the second material import 403.The second gas-static chamber 405 is annular housing, is arranged on the periphery of mixing induction tunnel 406; The first material import 401 is tapered opening, and tapered opening is towards the first material on the suction side.By the second gas-static chamber is set, make the second material be introduced into the second gas-static strong, after being uniformly distributed, then enter the second material import, make the gas-solvent that enters more even, mixed effect is better.Mix induction tunnel 406 and comprise first paragraph induction tunnel and the second segment induction tunnel setting gradually along the flow direction of the first material, the sectional area of first paragraph induction tunnel is less than the sectional area of second segment induction tunnel, and gap is arranged on the tube wall of second segment induction tunnel.By this kind of setting, can prevent, when the first material flows from the top down, exist some liquid or suspended particle to stop up gap, stop up the second material import, cause can not normally moving of equipment.By cone shape unremitting gap being set as gas-solvent import, make air inlet more even, more stable, dilution effect is better, mix or dilution after concentration stabilize, be evenly distributed.By the direction of the second material import is set, make the differential pressure action at two ends, gap, gas-solvent is entered in hybrid chamber, this kind of setting can prevent that the first material or the second material from flowing backwards, and affects dilution efficiency.By the adjustable of gap width is set, regulate the second material inlet, be convenient to be applied to multiple occasion, multiple dilute concentration.By the thin hybrid chamber in thick two in the middle of arranging, in hybrid chamber, form eddy current, further make to mix more even.By gas-static chamber is set, make the second material be introduced into gas-static chamber, gap can make γ-ray emission hydrostatic pressure, thereby after can even circumferential distributing, enter the second material import again, make the gas-solvent circle distribution that enters more even, mixed effect is better.
With the example that is connected between first segment experiment exposure chamber 110 and second section experiment exposure chamber 120, the inner core bottom of first segment experiment exposure chamber 110 is provided with the second aerosol diluter 73, the gasoloid of the inner core inside of first segment experiment exposure chamber 110 enters into the second aerosol diluter 73 by the first material import 401, after through compounding substances escape hole 408, enter in the inner core of second section experiment exposure chamber 120, the Third Road pressurized air that air compressor 111 produces is in gas inlet pipe enters into the gas feed 402 of the second aerosol diluter 73.
As shown in Figure 5,6, the utility model embodiment provides the structure of another kind of mouth and nose exposure unit 6 and the second aerosol diluter 73, and the second aerosol diluter 73 comprises front piece 46, middle part member 47 and back member 48; In front piece 46, be provided with gas the first air intake opening 41, be connected with gas inlet pipe; The second aerosol diluter 73 is fixed in inner core 101 by gas inlet pipe.In the rear end of middle part member 47, offer cylindricality cavity, back member 48 comprises for covering the cover plate at the opening part of cylindricality cavity; Cavity between cover plate and cylindricality cavity forms the first gas-static chamber 44, between the plane at the opening part place of cover plate and cylindricality cavity, has gap, and gap is static pressure chamber outlet 45; Back member 48 also comprises the lip-deep gas inlet pipe 42 that is vertically set on cover plate, on the outside surface of gas inlet pipe 42, is provided with external thread, between gas the first air intake opening 41 and cylindricality cavity, is provided with the internal thread through hole matching with external thread; Gas inlet pipe 42 is coaxial with cylindricality cavity, and the end of gas inlet pipe 42 is evenly provided with a plurality of ventholes 43.The aperture of static pressure chamber outlet 45 can regulate by the screw-in depth of gas inlet pipe 42.With the example that is connected between first segment experiment exposure chamber 110 and second section experiment exposure chamber 120, the inner core bottom of first segment experiment exposure chamber 110 is provided with the second aerosol diluter 73, the gasoloid of the inner core inside of first segment experiment exposure chamber 110 enters into by the gap between front piece 46 and the inwall of inner core 101 in the inner core of second section experiment exposure chamber 120, and the Third Road pressurized air that air compressor 111 produces is in gas inlet pipe enters into gas first import 41 of the second aerosol diluter 73.The outlet of static pressure chamber is the gap that is arranged on the circumference free of discontinuities adjustable size of the Bi Yu bottom surface, chamber in gas-static chamber formation, the gas that makes to enter into mixing place is more even, more stable, mix or dilution effect is better, mix or dilution after concentration stabilize, be evenly distributed.By the first gas passage is set in inside, the second substance channel is externally set, make structure simpler, mixing or air mix facilities volume are less, more practical.Be threaded connection and make the adjustable of gap width, regulate the first gas inlet, be convenient to be applied to multiple occasion, multiple dilute concentration.
The above is only preferred implementation of the present utility model; should be understood that; for those skilled in the art, do not departing under the prerequisite of the utility model principle, any improvements and modifications of making also should be considered as protection domain of the present utility model.
Claims (10)
1. the animal of concentration more than mouth and nose suck a dynamic exposure device, comprise for compressed-air actuated air compressor (111), gasoloid generation systems (1), mouth and nose exposure unit (6) and waste gas reclamation treatment system (9) are provided; Described mouth and nose exposure unit (6) comprises experimental group exposure chamber (63) and fixing device for experimental animal (62); Described gasoloid generation systems (1) comprises aerosol generator (11), for controlling first air flow controller (17) of the air inlet amount of described aerosol generator (11), for providing the medicinal liquid bottle (13) of liquid, the first aerosol diluter (12) being connected with the gasoloid outlet of described aerosol generator (11) to described aerosol generator (11) and for controlling second air flow controller (16) of the air inlet amount of described the first aerosol diluter (12); Described the first aerosol diluter (12) is connected with the gasoloid import (112) of described experimental group exposure chamber (63); The waste gas outlet of described experimental group exposure chamber (63) is connected with described waste gas reclamation treatment system (9); It is characterized in that,
Also comprise many concentration dilutions system (7); Described experimental group exposure chamber (63) comprises more piece experiment exposure chamber; Many concentration dilutions system (7) comprises the 3rd air flow controller (72) that is arranged on the second aerosol diluter (73) of respectively saving between described experiment exposure chamber and controls the air inlet amount in the second aerosol diluter (73).
2. many concentration animal mouth and nose according to claim 1 suck dynamic exposure device, it is characterized in that, described waste gas reclamation treatment system (9) comprises in turn connected waste gas collection box (91), device for drying and filtering (92), exhaust gas flow controller (93), manual ball valve (94), vacuum pump and high altitude discharge disposal system (96); Described waste gas collection box (91) is connected with described waste gas outlet.
3. many concentration animal mouth and nose according to claim 1 suck dynamic exposure device, it is characterized in that, described mouth and nose exposure unit (6) also comprises oxygen concentration sensor, pressure transducer, temperature sensor and humidity sensor and sampling of aerosol pipe, and described oxygen concentration sensor, described pressure transducer, described temperature sensor, described humidity sensor and described sampling of aerosol pipe are arranged on and respectively save in described experiment exposure chamber.
4. many concentration animal mouth and nose according to claim 1 suck dynamic exposure device, it is characterized in that, also comprise the micro-negative pressure disposal system of security mask cabinet (8) and vacuum (5);
Described security mask cabinet (8) comprises animal behavior remote monitoring camera (81), illuminating lamp (82), ultraviolet disinfection lamp (83), USB communication interface (84) and for gathering the thief hatch (85) of gasoloid sample;
The micro-negative pressure disposal system of described vacuum (5) enters atmosphere for preventing the gasoloid of a small amount of leakage in described security mask cabinet, and the micro-negative pressure disposal system of described vacuum (5) comprises retaining valve (51), differential pressure indicator (52) and vacuum pump.
5. according to the many concentration animal mouth and nose described in any one in claim 1-4, suck dynamic exposure device, it is characterized in that, also comprise sampling system (3) and control system (2).
6. many concentration animal mouth and nose according to claim 5 suck dynamic exposure device, it is characterized in that, described sampling system (3) comprises two-position two-way solenoid valve (31), aerosol concentration monitor (32) and gasoloid flow controller (35) and the vacuum pump being connected successively; Described two-position two-way solenoid valve (31) is connected with described sampling of aerosol pipe.
7. many concentration animal mouth and nose according to claim 5 suck dynamic exposure device, it is characterized in that, described control system (2) comprises industrial PC (21), touch screen computer (22), software programming control terminal (23), data collecting card (24), Control plate (25), contactor (26) and RS485 communication interface (27);
Described contactor (26), described Control plate (25), described data collecting card (24) and described industrial PC (21) are connected successively,
Described RS485 communication interface (27) connects described industrial PC (21), and described software programming control terminal (23) connects described industrial PC (21), and described touch screen computer (22) connects described industrial PC (21).
8. according to the many concentration animal mouth and nose described in any one in claim 1-4, suck dynamic exposure device, it is characterized in that, described mouth and nose exposure unit (6) also comprises control group exposure chamber (61).
9. according to the many concentration animal mouth and nose described in any one in claim 1-8, suck dynamic exposure device, it is characterized in that, described more piece experiment exposure chamber is three joint experiment exposure chamber or four joint experiment exposure chamber or five joint experiment exposure chamber.
10. according to the many concentration animal mouth and nose described in any one in claim 1-8, suck dynamic exposure device, it is characterized in that, in described gasoloid import (112), locate to arrange described the second aerosol diluter (73).
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| CN201320491797.0U CN203432981U (en) | 2013-08-13 | 2013-08-13 | Multi-concentration animal oral-nasal inhalation dynamic exposure equipment |
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| CN201320491797.0U CN203432981U (en) | 2013-08-13 | 2013-08-13 | Multi-concentration animal oral-nasal inhalation dynamic exposure equipment |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104374928A (en) * | 2013-08-13 | 2015-02-25 | 北京慧荣和科技有限公司 | Multi-concentration animal oral-nasal inhalation dynamic exposure equipment |
| CN109303623A (en) * | 2018-10-30 | 2019-02-05 | 中国环境科学研究院 | A kind of animal exposure experimental provision |
-
2013
- 2013-08-13 CN CN201320491797.0U patent/CN203432981U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104374928A (en) * | 2013-08-13 | 2015-02-25 | 北京慧荣和科技有限公司 | Multi-concentration animal oral-nasal inhalation dynamic exposure equipment |
| CN109303623A (en) * | 2018-10-30 | 2019-02-05 | 中国环境科学研究院 | A kind of animal exposure experimental provision |
| CN109303623B (en) * | 2018-10-30 | 2019-08-13 | 中国环境科学研究院 | A kind of animal exposure experimental provision |
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