CN113768657A - Gas inhalation contamination experiment exposure device - Google Patents

Gas inhalation contamination experiment exposure device Download PDF

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Publication number
CN113768657A
CN113768657A CN202111189991.9A CN202111189991A CN113768657A CN 113768657 A CN113768657 A CN 113768657A CN 202111189991 A CN202111189991 A CN 202111189991A CN 113768657 A CN113768657 A CN 113768657A
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gas
chamber
ball valve
control ball
mixing
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CN202111189991.9A
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CN113768657B (en
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刘进仁
高俊宏
王鸿
范小琳
卢青
李亮
刘志永
赵彬
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Ordnance Industry Hygiene Institute
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Ordnance Industry Hygiene Institute
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61DVETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A61D7/04Devices for anaesthetising animals by gases or vapours; Inhaling devices

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
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  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

The invention belongs to the technical field of contamination experiment devices, and particularly relates to an exposure device for a gas inhalation contamination experiment. The gas mixing device comprises a plurality of gas steel cylinders, a premixing cavity for receiving gas in the gas steel cylinders, a mixing cavity for receiving the gas in the premixing cavity and mixing the gas, and an exposure box for receiving the gas in the mixing cavity, wherein the outlet of each gas steel cylinder is provided with a first gas control ball valve and a gas mass flow controller, the gas mass flow controller is connected with the inlet of the premixing cavity, the inlet of the premixing cavity is also provided with a second gas control ball valve, and the outlet of the premixing cavity is connected with the mixing cavity through a third gas control ball valve; the blending cavity comprises a conveying chamber, a diffusion chamber, a mixing chamber and a collecting chamber which are sequentially communicated and is used for uniformly mixing a plurality of gases; the device can uniformly mix a plurality of gases in real time, and the mixing proportion can be adjusted at will.

Description

Gas inhalation contamination experiment exposure device
Technical Field
The invention belongs to the technical field of contamination experiment devices, and particularly relates to an exposure device for a gas inhalation contamination experiment.
Background
Taking explosion as an example, toxic and harmful components such as oxynitride, oxysulfide, carbon monoxide, carbon dioxide and the like contained in the explosion gas and the oxygen-deficient environment after explosion all can pose threats to the health of people. Limited by safety and experimental materials, laboratory studies of explosive gas biotoxicity are rare. Currently mature inhalation exposure devices allow animal exposure experiments to be performed on a single component and simply composed gas mixture. There is currently no mature animal exposure facility for mixed gases of multi-component gases with dynamically varying proportions between the components.
The animal contamination equipment that is applied to poisonous and harmful gas suction research at present mainly is by dynamic formula, quiet formula and three types of hybrid, and wherein dynamic formula contamination device has the continuous replenishment of external air current at the animal in-process that exposes, can guarantee that the concentration of test object is unchangeable, and the stability of temperature humidity and pressure in the contamination cabin can be guaranteed in the replacement of air current. Based on the above advantages, the dynamic contamination device has become the first tool for inhalation exposure research. However, in the study of the toxic effects of multi-component gases on organisms, the inhalation toxicant exposure devices currently on the market all have the following drawbacks: (1) the conventional inhalation contamination equipment does not have supporting facilities for premixing various gases in real time, and needs to be premixed, pressurized and bottled according to gas components, so that the difficulty is high and the danger is high. (2) The change range of the proportion of each component is large, the concentration of each component needs to be changed in the animal toxicant exposure process, the toxicity effect of the mixed gas is comprehensively analyzed, and the research on the toxicity of each component on organisms generated by different proportions is difficult to realize by using the bottled premixed gas. (3) The difficulty of researching the key components playing the toxic effect in the multi-component mixed gas by using the traditional dynamic contamination equipment is large. (4) The uniformity of the explosive gas plays an important role in animal contamination, and the existing contamination equipment does not have the function of uniformly mixing.
Disclosure of Invention
The invention aims to provide a gas inhalation contamination experiment exposure device, which solves the technical problem.
The purpose of the invention can be realized by the following scheme:
the utility model provides a gas inhales contamination experiment and exposes device, includes a plurality of gas steel cylinders of storing gas, is used for receiving gas mixes the chamber in advance of gas steel cylinder gas, is used for receiving mix chamber that gas and messenger's gas mixing in the chamber in advance and be used for receiving the exposure case of gas in the mixing chamber.
Mixing chamber is including the transport chamber, diffusion chamber, mixing chamber and the room of converging that communicate in proper order, transport chamber and mixing chamber are cylindricly, just the transport chamber diameter is less than the mixing chamber diameter, be provided with rotatable axial-flow impeller in the transport chamber, the diffusion chamber with it is hourglass hopper-shaped to converge the room, and with the mixing chamber sets up for central symmetry, the diffusion chamber with it all is provided with the grid structure in the room to converge, grid structure portion has the porous next door that configures into and surrounds a plurality of compartments, and this a plurality of compartments extend to the outflow terminal surface from the inflow terminal surface, constitute gaseous flow path.
Further, every the export of gas steel bottle all is provided with first gas control ball valve and gas mass flow controller, gas mass flow controller with the access connection in advance mixing chamber, still be provided with the gaseous control ball valve of second in advance mixing chamber's import, in advance mixing chamber's export through third gas control ball valve with the mixing chamber is connected, in advance mixing chamber still is connected with first gas analysis appearance.
Furthermore, each gas steel cylinder is provided with a pressure reducing valve.
Furthermore, each gas mass flow controller is connected with the same flow control display instrument.
Furthermore, the axial-flow impeller passes through the rotating electrical machines drive, the axial-flow impeller is connected with the one end of pivot, the pivot rotate connect in the inner wall of transport chamber, the other end of pivot is provided with first bevel gear, first bevel gear and second bevel gear meshing, second bevel gear with the output shaft of rotating electrical machines, just the rotating electrical machines set up in the outer diapire of transport chamber.
Furthermore, the narrow-end of the collection chamber is connected with the first end of a four-way pipe through a fourth gas control ball valve, the second end of the four-way pipe is connected with a vacuum pump through a fifth gas control ball valve, the third end of the four-way pipe is connected with a second gas analyzer through a sixth gas control ball valve, and the fourth end of the four-way pipe is connected with the exposure box through a seventh gas control ball valve.
Further, expose the case and be the double-deck high transparent thickening organic glass box, be equipped with the intermediate layer between the double-deck, box inlayer lateral wall evenly is equipped with a plurality of gas pockets, the box top is equipped with the animal business turn over hatch door of taking seal ring, the outer lateral wall of box still is provided with first gas outlet, second gas outlet and third gas outlet, first gas outlet is connected with exhaust-gas treatment system through eighth gas control ball valve, the second gas outlet with be connected with the third gas analysis appearance through ninth gas control ball valve, the third gas outlet is connected with the barometer through tenth gas control ball valve.
Furthermore, the gas control ball valve is also provided with a single chip microcomputer and a control panel, all the gas control ball valves are electromagnetic valves, and the control panel, the rotating motor and all the electromagnetic valves are electrically connected with the single chip microcomputer.
Compared with the prior art, the invention has the following beneficial effects:
1. the gas mass flow controller is used for accurately regulating and controlling the flow of each gas in real time, so that the exposed gases with different mixing ratios can be quickly obtained.
2. The premixing cavity is provided with the first gas analyzer, the concentration of each component of the mixed gas can be monitored in real time, and accurate control over the exposed gas components and the concentration is achieved by combining the mass flow controller.
3. The mixing cavity can uniformly mix a plurality of gases, the axial-flow impeller primarily disperses and conveys the gases to the diffusion chamber, the mixing chamber and the collecting chamber, and the gases are further uniformly mixed by the partition of the partition wall with the grid structure.
4. Expose the case and adopt high printing opacity organic glass material, conveniently observe changes such as animal contamination in-process physiology, action, expose the external pressure gauge of case and can combine the adjustable cabin internal pressure of gas outlet, expose the case and set to the bilayer, a plurality of gas pockets are established to the inlayer, release gas that can be even.
5. The toxic effects of different types of gases in the mixed components can be studied in a targeted manner.
6. Compared with the mainstream inhalation contamination equipment used at present, the invention has the advantages of smaller volume, lower cost, simple structure, convenient operation and convenient cleaning.
Drawings
FIG. 1 is a schematic structural diagram of the present invention.
FIG. 2 is a schematic cross-sectional view of a diffusion chamber of the present invention.
In the figure, 1-gas cylinder, 2-premix chamber, 3-exposure chamber, 4-gas mass flow controller, 5-first gas analyzer, 6-delivery chamber, 7-diffusion chamber, 8-mixing chamber, 9-collection chamber, 10-axial flow impeller, 11-vacuum pump, 12-second gas analyzer, 13-flow control display, 14-rotating motor, 15-waste gas treatment system, 16-third gas analyzer, 17-barometer.
Detailed Description
The invention is described in detail below with reference to the figures and the specific embodiments, but the invention should not be construed as being limited thereto. The technical means used in the following examples are conventional means well known to those skilled in the art, and materials, reagents and the like used in the following examples can be commercially available unless otherwise specified.
Example 1
Referring to fig. 1-2, the gas inhalation contamination experiment exposure device of the present embodiment includes a plurality of gas cylinders 1 with pressure reducing valves, a premixing chamber 2 for receiving gas in the gas cylinders 1, a mixing chamber for receiving gas in the premixing chamber 2 and mixing the gas, and an exposure box 3 for receiving gas in the mixing chamber;
the outlet of each gas steel cylinder 1 is provided with a first gas control ball valve and a gas mass flow controller 4, the gas mass flow controller 4 is connected with the inlet of the premixing cavity 2, the inlet of the premixing cavity 2 is also provided with a second gas control ball valve, the outlet of the premixing cavity 2 is connected with the mixing cavity through a third gas control ball valve, and the premixing cavity is also connected with a first gas analyzer 5;
the mixing cavity comprises a conveying chamber 6, a diffusion chamber 7, a mixing chamber 8 and a collecting chamber 9 which are sequentially communicated, the conveying chamber 6 and the mixing chamber 8 are both cylindrical, the diameter of the conveying chamber 6 is smaller than that of the mixing chamber 8, a rotatable axial-flow impeller 10 is arranged in the conveying chamber 6, the diffusion chamber 7 and the collecting chamber 9 are both funnel-shaped and are symmetrically arranged by taking the mixing chamber 8 as a center, grid structures are arranged in the diffusion chamber 7 and the collecting chamber 9, the grid structures are provided with porous partition walls configured to surround a plurality of compartments, and the compartments extend from an inflow end face to an outflow end face to form a gas flow path;
the narrow mouth end of the collecting chamber 9 is connected with the first end of the four-way pipe through a fourth gas control ball valve, the second end of the four-way pipe is connected with a vacuum pump 11 through a fifth gas control ball valve, the third end of the four-way pipe is connected with a second gas analyzer 12 through a sixth gas control ball valve, and the fourth end of the four-way pipe is connected with the exposure box 3 through a seventh gas control ball valve.
In this embodiment, each gas mass flow controller 4 is connected to the same flow control display 13 for monitoring the gas flow.
In this embodiment, the axial-flow impeller 10 is driven by the rotating motor 14, the axial-flow impeller 10 is connected with one end of the rotating shaft, the rotating shaft is rotatably connected to the inner wall of the conveying chamber, the other end of the rotating shaft is provided with a first bevel gear, the first bevel gear is engaged with a second bevel gear, the second bevel gear is connected with an output shaft of the rotating motor 14, and the rotating motor 14 is arranged on the outer bottom wall of the conveying chamber 6, so as to disperse the gas flowing out of the premixing cavity 2 preliminarily, on the other hand, the gas is conveyed to the diffusion chamber 7, the mixing chamber 8 and the collection chamber 9, the gas is divided by the grid structure in the diffusion chamber 7, further dispersed, mixed in the mixing chamber 8, and then collected into a small strand of uniformly mixed gas by the grid structure in the collection chamber 9.
In the embodiment, the exposure box 3 is a double-layer high-transparency thickened organic glass box body, an interlayer is arranged between the double layers, and the side wall of the inner layer of the box body is uniformly provided with a plurality of air holes; the top of the box body is provided with an animal in-out cabin door with a sealing washer, the animal is in-out, the outer side wall of the box body is further provided with a first gas outlet, a second gas outlet and a third gas outlet, the first gas outlet is connected with a waste gas treatment system 15 through an eighth gas control ball valve, the waste gas is discharged in a treatment mode, the second gas outlet is connected with a third gas analyzer 16 through a ninth gas control ball valve, the concentration of each component of mixed gas is monitored in real time, and the third gas outlet is connected with a barometer 17 through a tenth gas control ball valve and is used for monitoring the gas pressure in the cabin in real time.
In this embodiment, still be provided with singlechip and control panel, all the gas control ball valve is the solenoid valve, control panel, rotating electrical machines 14 and all solenoid valves all with the singlechip electricity is connected, according to required gas quantity, input instruction in advance, by the switching of singlechip automatic control solenoid valve, rotating electrical machines.
According to the exposure device for the gas inhalation contamination experiment, the flow of each gas is accurately regulated and controlled in real time by using the mass flow controller, so that the exposed gases with different mixing ratios can be quickly obtained, the first gas analyzer 5 is arranged in the premixing cavity 2, the concentration of each component of the mixed gas can be monitored in real time, and the components and the concentration of the exposed gases are accurately controlled by combining the mass flow controller 4. Through setting up the mixing chamber, by the preliminary dispersion of axial-flow type impeller 10 with the gaseous mixture of input to conveying gas to diffusion chamber 7, mixing chamber 8 and collection room 9, gaseous through the partition of the next door of grid structure, further with gaseous mixing, make gaseous exposure even.
While preferred embodiments of the present invention have been described, additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. Therefore, it is intended that the appended claims be interpreted as including preferred embodiments and all such alterations and modifications as fall within the scope of the invention.
It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.

Claims (8)

1. The utility model provides a gaseous inhalation contamination experiment exposes device, includes a plurality of gas steel bottle (1) of storing gas, is used for receiving gas mixes chamber (2), is used for receiving in gas steel bottle (1) gas mixes the chamber with being used for receiving in mixing chamber (2) gas and the mixing chamber that makes the gas mixing in the mixing chamber gaseous exposure case (3), its characterized in that:
mixing chamber is including transport chamber (6), diffusion chamber (7), mixing chamber (8) that communicate in proper order and collect room (9), transport chamber (6) and mixing chamber (8) are cylindricly, just transport chamber (6) diameter is less than mixing chamber (8) diameter, be provided with rotatable axial-flow impeller (10) in transport chamber (6), diffusion chamber (7) with it is hourglass hopper-shaped to collect room (9), and the two with mixing chamber (8) are central symmetry and set up, diffusion chamber (7) with it all is provided with the grid structure in room (9) to collect, grid structure portion has the porous next door that configures into to surround a plurality of compartments, and this a plurality of compartments extend to the outflow terminal surface from the inflow terminal surface, constitute gaseous flow path.
2. The gas inhalation contamination experiment exposure device according to claim 1, wherein an outlet of each gas steel cylinder (1) is provided with a first gas control ball valve and a gas mass flow controller (4), the gas mass flow controller (4) is connected with an inlet of the premixing cavity (2), an inlet of the premixing cavity (2) is further provided with a second gas control ball valve, an outlet of the premixing cavity (2) is connected with the mixing cavity through a third gas control ball valve, and the premixing cavity is further connected with a first gas analyzer (5).
3. A gas inhalation contamination experiment exposure apparatus according to claim 2, wherein each of the gas cylinders (1) is provided with a pressure reducing valve.
4. A gas inhalation contamination experiment exposure apparatus according to claim 3, wherein each of the gas mass flow controllers (4) is connected to the same flow control display (13).
5. A gas inhalation contamination experiment exposure apparatus according to claim 4, wherein the axial flow impeller (10) is driven by a rotating motor (14), the axial flow impeller (10) is connected with one end of a rotating shaft, the rotating shaft is rotatably connected with the inner wall of the conveying chamber, the other end of the rotating shaft is provided with a first bevel gear, the first bevel gear is meshed with a second bevel gear, the second bevel gear is connected with an output shaft of the rotating motor (14), and the rotating motor (14) is arranged on the outer bottom wall of the conveying chamber (6).
6. A gas inhalation contamination experiment exposure apparatus according to claim 5, wherein the narrow end of the collection chamber (9) is connected to the first end of a four-way pipe through a fourth gas control ball valve, the second end of the four-way pipe is connected to the vacuum pump (11) through a fifth gas control ball valve, the third end of the four-way pipe is connected to the second gas analyzer (12) through a sixth gas control ball valve, and the fourth end of the four-way pipe is connected to the exposure box (3) through a seventh gas control ball valve.
7. The gas inhalation contamination experiment exposure device according to claim 6, wherein the exposure box (3) is a double-layer high-transparency thickened organic glass box body, an interlayer is arranged between the double layers, a plurality of air holes are uniformly formed in the side wall of the inner layer of the box body, an animal in-out cabin door with a sealing gasket is arranged at the top of the box body, a first air outlet, a second air outlet and a third air outlet are further formed in the side wall of the outer layer of the box body, the first air outlet is connected with a waste gas treatment system (15) through an eighth gas control ball valve, the second air outlet is connected with a third gas analyzer (16) through a ninth gas control ball valve, and the third air outlet is connected with a barometer (17) through a tenth gas control ball valve.
8. The gas inhalation contamination experiment exposure device according to claim 7, further comprising a single chip microcomputer and a control panel, wherein all the gas control ball valves are electromagnetic valves, and the control panel, the rotating electrical machine (14) and all the electromagnetic valves are electrically connected with the single chip microcomputer.
CN202111189991.9A 2021-10-12 2021-10-12 Exposure device for gas inhalation contamination experiment Active CN113768657B (en)

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CN113768657B CN113768657B (en) 2024-05-10

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Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040216737A1 (en) * 2001-07-26 2004-11-04 Anderson Leslie B. System for anesthetizing laboratory animals
US20110011160A1 (en) * 2007-06-28 2011-01-20 Inhalation Sciences Sweden Ab Exposure System
CN102191177A (en) * 2011-03-28 2011-09-21 天津开发区合普工贸有限公司 Cell radon exposure experimental device
CN202128563U (en) * 2011-07-06 2012-02-01 天津开发区合普工贸有限公司 Rodent only-nasal type inhalation toxicity exposure test device
CN102389339A (en) * 2011-07-06 2012-03-28 天津开发区合普工贸有限公司 Only-nose inhaling poison exposure experimental equipment for rodent
CN105974053A (en) * 2015-10-29 2016-09-28 兵器工业卫生研究所 Armoured vehicle cabin harmful gas simulation experiment system
CN106175975A (en) * 2016-07-11 2016-12-07 中国环境科学研究院 A kind of Powder aerosol dynamic formula per os nasal inhalation contamination device
US20200023152A1 (en) * 2016-02-07 2020-01-23 U.S. Government, As Represented By The Secretary Of The Army Oro-nasal Inhalation Plethysmography Mask Exposure System
CN216908248U (en) * 2021-10-12 2022-07-08 兵器工业卫生研究所 Multicomponent gas inhales contamination experiment and exposes device

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040216737A1 (en) * 2001-07-26 2004-11-04 Anderson Leslie B. System for anesthetizing laboratory animals
US20110011160A1 (en) * 2007-06-28 2011-01-20 Inhalation Sciences Sweden Ab Exposure System
CN102191177A (en) * 2011-03-28 2011-09-21 天津开发区合普工贸有限公司 Cell radon exposure experimental device
CN202128563U (en) * 2011-07-06 2012-02-01 天津开发区合普工贸有限公司 Rodent only-nasal type inhalation toxicity exposure test device
CN102389339A (en) * 2011-07-06 2012-03-28 天津开发区合普工贸有限公司 Only-nose inhaling poison exposure experimental equipment for rodent
CN105974053A (en) * 2015-10-29 2016-09-28 兵器工业卫生研究所 Armoured vehicle cabin harmful gas simulation experiment system
US20200023152A1 (en) * 2016-02-07 2020-01-23 U.S. Government, As Represented By The Secretary Of The Army Oro-nasal Inhalation Plethysmography Mask Exposure System
CN106175975A (en) * 2016-07-11 2016-12-07 中国环境科学研究院 A kind of Powder aerosol dynamic formula per os nasal inhalation contamination device
CN216908248U (en) * 2021-10-12 2022-07-08 兵器工业卫生研究所 Multicomponent gas inhales contamination experiment and exposes device

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