CN106175975B - A kind of oral nasal inhalation contamination device of Powder aerosol dynamic formula - Google Patents
A kind of oral nasal inhalation contamination device of Powder aerosol dynamic formula Download PDFInfo
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- CN106175975B CN106175975B CN201610541458.7A CN201610541458A CN106175975B CN 106175975 B CN106175975 B CN 106175975B CN 201610541458 A CN201610541458 A CN 201610541458A CN 106175975 B CN106175975 B CN 106175975B
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
- A61D7/04—Devices for anaesthetising animals by gases or vapours; Inhaling devices
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Abstract
The present invention relates to a kind of oral nasal inhalation contamination device of Powder aerosol dynamic formula, the contamination device includes exposure chamber, fixing device for experimental animal, air compressor, powder diffuser, diffusive gas flow pipeline, rapping apparatus, dust aerosol sample channel, opposite-flushing type mixes room, the dilution air flow that liquidates pipeline, blower fan, microcomputer control unit, powder diffuser is used to solve quantitative sprinkling and the diffusion problem of solid tested material powder, powder diffuser is connected to opposite-flushing type and mixes room by dust aerosol sample channel, opposite-flushing type mixes the top that exposure chamber is fixed in room, connected with exposure chamber inside, exposure chamber is provided with exposure chamber interface, the front end of fixing device for experimental animal is connected by exposure chamber interface with exposure chamber, microcomputer control unit is used to regulate and control the operational factor of contamination device.Invention emulates the Powder aerosol exposure chamber in actual environment, tested material uniform concentration distribution, exposed state stabilization, experimental result is reproducible, and facility swift to operate is applied widely.
Description
Technical field
The present invention relates to a kind of experimental provision, more particularly to a kind of oral nasal inhalation contamination device of Powder aerosol dynamic formula.
Background technology
Existing Powder aerosol suction exposure contamination equipment mainly has quiet formula suction exposure contamination and dynamic formula to suck exposure
Two kinds of contamination.The shortcoming of quiet formula suction exposure toxicant exposure cabinet is：Tested material concentration is gradually reduced (molten for powder gas in toxicant exposure cabinet
Glue, due to settlement action, its concentration can be reduced substantially)；Experimental animal has through the possibility of skin absorption；With entering for experiment
OK, decrease in oxygen partial pressure is obvious.The shortcoming of existing dynamic inhalation contamination equipment is：Tested material in the form of the Powder aerosol including
Flow at high speed in the less pipeline in footpath, does not meet the exposure chamber of actual environment, while the amount for consuming tested material is larger；For stream
The bad powder of dynamic property (easily pile up and lump), it is impossible to realize quantitative control exactly, and be likely to result in pipeline blockage；Structure
It is complex with control, it is not easy to operate.
The content of the invention
The present invention be directed to above-mentioned the deficiencies in the prior art, and design a kind of oral snuffing of Powder aerosol dynamic formula of assembling
Enter to expose contamination device.
The invention provides a kind of oral nasal inhalation contamination device of Powder aerosol dynamic formula, it is characterised in that the contamination
Device includes exposure chamber, fixing device for experimental animal, air compressor, powder diffuser, diffusive gas flow pipeline, rapping apparatus, powder
Dust and gas colloidal sol sample channel, opposite-flushing type mix room, the dilution air flow that liquidates pipeline, blower fan, microcomputer control unit；
The air compressor is connected by the diffusive gas flow pipeline with the powder diffuser,
The powder diffuser is used to solve quantitative sprinkling and the diffusion problem of solid tested material powder, is filled with the rapping
Put and connected by vertical axle, the rapping apparatus is disintegrated upright accumulation and the caking phenomenon of powder by rapping, so as to protect
The quantitative control of the powder diffuser is demonstrate,proved, the powder diffuser is connected to described by the dust aerosol sample channel
Opposite-flushing type mixes room,
The opposite-flushing type mixes the top that the exposure chamber is fixed in room, and the opposite-flushing type is mixed in room and the exposure chamber
Portion is connected, and the opposite-flushing type is mixed room and is connected with the air compressor by the dilution air flow pipeline that liquidates,
Exposure chamber interface is provided with around four the week side of boss walls of the exposure chamber, the front end of the fixing device for experimental animal passes through institute
Exposure chamber interface is stated to be connected with the exposure chamber,
The bottom of the exposure chamber is connected by pipeline with the blower fan,
The microcomputer control unit is used to regulate and control the operational factor of the contamination device.
Further, the contamination device also includes main cabinet, exhaust purifier, parameter display unit, the main cabinet
Body has base plate, middle level dividing plate, top board, four columns, and the air compressor is placed in outside the main cabinet, the powder diffusion
Device is individually fixed in inside and outside the top of the main cabinet with the rapping apparatus；The exposure chamber is fixed on the main cabinet
On the middle level dividing plate of body；The exhaust purifier, the microcomputer control unit and the parameter display unit be fixed on it is described in
On crossbeam under layer dividing plate, the blower fan is fixed on the base plate of the main cabinet, four column bottoms dress of the main cabinet
With universal wheel, the exhaust purifier is connected by pipeline with the bottom of the exposure chamber, and the parameter display unit is used to show
Show the running status and parameter of the contamination device.
Further, the exposure chamber is the barrel-shaped structure of big volume, major diameter, and lower end is connected with taper dust receipts
Storage, exposure chamber interface takes staggered arrangement, and the exposure chamber interface is furnished with blind plate, can be with occluding member interface.
Further, the fixing device for experimental animal includes movable carriage, elastic reducing-fixing band, animal accommodation chamber, work
Dynamic baffle plate, excrement urine collector, the animal accommodation chamber are made of transparent organic glass, and its front end is mutually fitted with animal head
The tapered conical bucket answered；The main part of the animal accommodation chamber is barrel-shaped cylinder, and there is different in width its top and bottom
Open slot, open top groove is used for the movement and fixation of the sideboard, and the open slot of bottom is easy to the excrement that animal drains
Just urine enters the excrement urine collector that be connected with the animal accommodation chamber, the bottom of the animal accommodation chamber be equipped with and
The supporting latch of the excrement urine collector upper groove, is coordinated by the groove and the latch, facilitates the excrement to urinate
The installation and disassembly, cleaning of collection；The sideboard by can be elastic nut and with certain thickness circular baffle plate group
Into, its configuration circular baffle plate inside have with animal buttocks be adapted curved surface and can allow animal tail pass through the sideboard
Circular hole；
The contamination device also includes first support, and the movable carriage is placed in the relevant position of the first support
Place, the main body of the fixing device for experimental animal is placed in on the mounted movable carriage, with the movable carriage
The elastic reducing-fixing band of configuration fixes the fixing device for experimental animal.
Further, the first support be followed successively by from top to bottom by the base of stainless steel substrates material, lower floor, middle level and
Upper strata, is fixed between each layer by threaded rod and nut, and the height per layer height with exposure chamber interface is adapted.
Further, the powder diffuser includes magnetic valve, sprayer, medicine bottle, and the diffusive gas flow pipeline is passed through
The magnetic valve is connected with the sprayer；The medicine bottle is fixed on the sprayer by screw thread and sealing gasket；The spray
Day with fog mixes room and is connected by the Powder aerosol sample channel and the opposite-flushing type, and certain density Powder aerosol is sent
Enter the opposite-flushing type and mix room；The microcomputer control unit is connected by data wire with the magnetic valve.
Further, the sprayer includes inner sleeve, and sheath tracheae, the sprayer is compressed using double gas circuit structures
Air from the diffusive gas flow pipeline into the sprayer after be divided into two-way, the medicine bottle bottom is opened below into all the way, by powder
Shape medicine blows afloat, and is sprayed outward from the inner sleeve；Another road air-flow is bypassed from sheath tracheae described in top, on the outside of the inner sleeve
Form parcel sheath gas.The powdered drug composition that the sheath gas is sent out with the inner sleeve is sent out outward for mixed airflow, further
Room is mixed into opposite-flushing type.
Further, the rapping apparatus includes electromagnet, cover plate, back-moving spring, second support, and the cover plate is whole
The top board of individual toxicant exposure cabinet, the electromagnet is fixed on the cover plate；Four threaded rods that the second support is equipped with by it
It is fixed on the cover plate, the vibrating shaft on the electromagnet passes through circular hole and the institute at the cover plate and the second support center
State the firm connection of sprayer；Screwed stainless steel shaft is installed with the middle of the back-moving spring, through in the second support
Circular hole is firm with the sprayer to be connected.
Further, the opposite-flushing type mixes room has mixing chamber, and the mixing chamber communicates with the exposure chamber, described
The mouth of pipe of dust aerosol sample channel and the middle of the dilution air flow pipeline mouth of pipe positioned at the mixing chamber that liquidate, and on
Lower relative, internal diameter is in the same size.
A kind of control method of the oral nasal inhalation contamination device of Powder aerosol dynamic formula of the invention, it is characterised in that
Step 1, open general supply at the microcomputer control unit, now microcomputer control unit, parameter display unit and
Blower fan is in energization operating condition, and the program of microcomputer control unit is set into " standby " pattern, then according to the parameter of display,
Set the compressor flow of requirement of experiment；The power supply and its air delivery valve of air compressor are opened, and output pressure is set.
Step 2, it is under " standby " mode state in equipment, removes the dress sample bottle on powder diffuser, will be appropriate
After powdered samples load dress sample bottle, then install back on powder diffuser；What selection to be run at microcomputer control unit enters
After sample program, the property according to given the test agent powder chooses whether to run rapping apparatus；Now, contamination equipment starts according to target
The corresponding parameter operation of exposure concentrations.
" cleaning " program of operation microcomputer control unit before step 3, shutdown, after the operation of this program is finished, closes air
Compressor and its air delivery valve, finally close general supply.
The beneficial effects of the present invention are：
(1) exposure chamber of the invention use big volume, the barrel-like structure of major diameter, the sedimentation of dust is similar in air
The natural subsidence of grain thing, simulates the Powder aerosol exposure chamber in actual environment.
(2) exposure chamber interface takes rational staggered arrangement, both can guarantee that experiment capacity, can prevent mutually masking dry again
Disturb, advantageously ensure that the uniformity of experimental animal exposed environments.Interface is furnished with blind plate, can block part of interface, conveniently carries out
The experiment of more small-scale (experimental animal quantity).
(3) powder diffuser can stably realize the quantitative sprinkling of powder medicaments, and opposite-flushing type mixes room and can guarantee that exposure
Tested material uniform concentration distribution in room, exposed state stabilization, after experimental animal exposure contamination, experimental result is reproducible.
(4) present invention can easily control the ventilation rate of exposure chamber by changing compressor flow, while keeping suitable oxygen
Partial pressure；By adjusting the parameters such as the pressure of air-flow, flow, sprinkling frequency and ventilation rate, reach in dosage and exposure chamber
The control of tested material concentration, facility swift to operate；Re-scaled by adjusting parameter, the rapping apparatus of outfit can ensure difference
The quantitative sprinkling of the powder tested material of flow behavior, it is applied widely.
Brief description of the drawings
Fig. 1 is the oral nasal inhalation contamination device structural representation of a kind of Powder aerosol dynamic formula of the present invention；
Fig. 2 is exposure chamber schematic diagram in the present invention；
Fig. 3 is exposure chamber fixing device for experimental animal, holder combination schematic diagram in the present invention；
Fig. 4 is medium-height trestle schematic diagram of the present invention；
Fig. 5 is fixing device for experimental animal structural decomposition diagram in the present invention；
Fig. 6 is fixing device for experimental animal combination diagram in the present invention；
Fig. 7 is rapping apparatus structural representation in the present invention；
Fig. 8 is powder diffuser floor map in the present invention；
Fig. 9 is powder diffuser internal sprayer sectional view in the present invention；
Figure 10 is opposite-flushing type mixing cell structure schematic diagram in the present invention.
Wherein：1st, main cabinet, 2, exposure chamber, 3, exposure chamber interface, 4, fixing device for experimental animal, 5, support, 6, air pressure
Contracting machine, 7, powder diffuser, 8, diffusive gas flow pipeline, 9, rapping apparatus, 10, dust aerosol sample channel, 11, opposite-flushing type mixes
Even room, 12, the dilution air flow that liquidates pipeline, 13, exhaust purifier, 14, blower fan, 15, microcomputer control unit, 16, parameter display it is single
Unit, 17, movable carriage, 18, elastic reducing-fixing band, 19, animal accommodation chamber, 20, sideboard, 21, excrement urine collector,
22nd, latch, 23, circular hole, 24, electromagnet, 25, cover plate, 26, back-moving spring, 27, support, 28, magnetic valve, 29, sprayer, 30,
Medicine bottle, 31, data wire, 32, inner sleeve, 33, sheath tracheae, 34, powdered drug, 35, sheath gas, 36, mixed airflow, 37, mix chamber.
Specific embodiment
Technical scheme is described in detail below with reference to accompanying drawing 1-10.
As shown in figure 1, the invention provides a kind of oral nasal inhalation contamination device of Powder aerosol dynamic formula, including：Main cabinet
Body 1, exposure chamber 2, exposure chamber interface 3, fixing device for experimental animal 4, support 5, air compressor 6, powder diffuser 7, diffusion gas
Flow tube road 8, rapping apparatus 9, dust aerosol sample channel 10, opposite-flushing type mix room 11, the dilution air flow that liquidates pipeline 12, tail gas
Clarifier 13, blower fan 14, microcomputer control unit 15, parameter display unit 16.
As shown in figure 1, air compressor 6 is placed in outside main cabinet 1, powder diffuser 7 passes through vertical axle with rapping apparatus 9
Connection, and be individually fixed in inside and outside the top of main cabinet 1；Exposure chamber 2 is fixed on the middle level dividing plate of main cabinet 1；Tail
Gas purifier 13, microcomputer control unit 15 and parameter display unit 16 are fixed on the crossbeam under the dividing plate of middle level, and blower fan 14 is fixed
On the base plate of main cabinet 1, four column bottoms assembling universal wheel of main cabinet 1 is easy to contamination device to move.
Air compressor 6 is used to provide clean compressed air, is connected with powder diffuser 7 by diffusive gas flow pipeline 8, will
Clean compressed air feeding powder diffuser 7；Room 11 is mixed by liquidate dilution air flow pipeline 12 and opposite-flushing type to be connected, by cleaning
Compressed air feeding opposite-flushing type mixes room 11.
Powder diffuser 7 mixes room 11 and is connected by dust aerosol sample channel 10 and opposite-flushing type.
The bottom of exposure chamber 2 is connected by pipeline with exhaust purifier 13, and exhaust purifier 13 is connected with blower fan 14.Blower fan
14 are used to extract the mixed gas in exposure chamber 2 out, and mixed gas feeding exhaust purifier 13 is purified.Blower fan 14 was both protected
The air circulation in exposure chamber 2 is demonstrate,proved, has been that exposure chamber 2 provides suitable partial pressure of oxygen, it is real waste gas feeding can will to be tested after purification again
Test chamber ventilated system.
Microcomputer control unit 15 is used to control the operation of the contamination device.
Parameter display unit 16 is used to show the contamination device running status and parameter.
As shown in Fig. 2 exposure chamber 2 is big volume, the barrel-shaped structure of major diameter, the sedimentation of dust is similar in air
The natural subsidence of grain thing, the exposure chamber in simulation actual environment, lower end is connected with taper dust collector, exposure chamber interface 3
It is circumferentially positioned on four the week side of boss walls of exposure chamber 2, and takes rational staggered arrangement, both can guarantee that experiment capacity, can prevents again
Mutually masking interference, advantageously ensures that the uniformity of experimental animal exposed environments.Exposure chamber interface 3 is furnished with blind plate, can block
Part of interface, conveniently carries out the experiment of more small-scale (experimental animal quantity).
Support 5 is placed on the middle level dividing plate of main cabinet 1 and around exposure chamber 2, as shown in figure 3, be made with stainless steel,
Fixing device for experimental animal 4 can be fixed on support 5 by movable carriage 17 and its subsidiary elastic reducing-fixing band 18；Such as Fig. 4
Shown, support 5 is followed successively by base, lower floor, middle level and the upper strata of stainless steel substrates material from top to bottom, and threaded rod is passed through between each layer
Fixed with nut, the height per layer height with exposure chamber interface 3 is adapted, in order to stable fixed fixing device for experimental animal 4.
Fixing device for experimental animal 4 is fixed on support 5, the front end of fixing device for experimental animal 4 by exposure chamber interface 3 with it is sudden and violent
Dew room 2 connects.As shown in figure 5, fixing device for experimental animal 4 includes movable carriage 17, elastic reducing-fixing band 18, animal accommodation chamber
19th, sideboard 20, excrement urine collector 21.Animal accommodation chamber 19 makes of transparent organic glass, and its front end is and animal
The adaptable tapered conical bucket of head；The main part of animal accommodation chamber 19 is barrel-shaped cylinder, and its top and bottom has not
With the open slot of width, open top groove is used for the movement and fixation of sideboard 20, and the open slot of bottom is easy to animal to drain
Excrement urine enter the excrement urine collector 21 that be connected with animal accommodation chamber 19, bottom is equipped with and excrement urine collector 21
The supporting latch 22 of upper groove, is coordinated by groove and latch 22, facilitates the installation and disassembly, cleaning of excrement urine collector 21；
Sideboard 20 by can be elastic nut and constitute with certain thickness circular baffle plate, have inside the circular baffle plate of its configuration with
The adaptable curved surface of animal buttocks and can allow the circular hole 23 that animal tail passes through.Movable carriage 17 is placed in the corresponding positions of support 5
Place is put, the main body of fixing device for experimental animal 4 is placed in on mounted movable carriage 17, as shown in fig. 6, using movable carriage
The elastic reducing-fixing band 18 configured on 17 is by the fix tightly of fixing device for experimental animal 4；By experimental animal from the tail of fixing device for experimental animal 4
Animal accommodation chamber 19 is put at end opening, fixed sideboard 20 to appropriate location is installed, the mouth and nose of animal is stretched out animal and hold
The front end in cabin 19 is received, to contact exposed environments, and by the tail of experimental animal through the circular hole 23 on sideboard 20.
The effect of rapping apparatus 9 is that by rapping upright accumulation and caking phenomenon to be disintegrated powder, so as to ensure
The quantitative control of powder diffuser 7, expands the scope of application of diffuser, rapping apparatus 9 it is main by electromagnet 24, it is cover plate 25, multiple
Position spring 26, support 27 are constituted, as shown in fig. 7, cover plate 25 is the top board of whole toxicant exposure cabinet, electromagnet 24 is fixed by screws in
On cover plate 25；Support 27 is fixed on cover plate 25 by its four threaded rod being equipped with, and the vibrating shaft on electromagnet 24 passes through lid
Plate 25 and the circular hole at the center of support 27 are firm with sprayer 29 to be connected；Screwed stainless steel is installed with the middle of back-moving spring 26
Axle, the circular hole through on support 27 is firm with sprayer 29 to be connected.When electromagnet 24 is powered, carried on vibrating shaft, back-moving spring 26
Compression；When electromagnet 24 is powered off, vibrating shaft is moved down, and back-moving spring 26 resets；By the adhesive of electromagnet 24 make with sprayer 29
Medicine bottle 30 move up, electromagnet 24 power off after sprayer 29 is resetted in the presence of back-moving spring 26 formed rapping act on,
It is disintegrated upright accumulation and the caking of powder；By regulating time controller, the rapping frequency of control device can be applicable device
In the powder of different mobility, simultaneously because back-moving spring 26 has certain cushioning effect, be unlikely to cause medicine bottle 30 due to
High vibration and come off.Additionally, rapping program is relevant with sample introduction frequency, typically rapping once, can be according to receiving during sample introduction twice
Examination thing characteristic makes corresponding change.
Powder diffuser 7 is used to solve the problems, such as the quantitative sprinkling of drug powder, as shown in figure 8, powder diffuser 7 includes electricity
Magnet valve 28, sprayer 29, medicine bottle 30.Diffusive gas flow pipeline 8 passes through magnetic valve 28, is connected with sprayer 29；Medicine bottle 30 passes through spiral shell
Line and sealing gasket are fixed on sprayer 29, can at any time be dismantled and be varied；The Powder aerosol sample channel being connected with sprayer 29
10, further mix room 11 with opposite-flushing type and be connected, certain density Powder aerosol feeding opposite-flushing type is mixed into room 11；Microcomputer control
Unit processed 15 is connected by data wire 31 with magnetic valve 28, for controlling rapping frequency, is connected with magnetic valve 28 by data wire 31
Connect, for controlling compressed air stream, further control sample introduction frequency and sample size.Microcomputer control unit 15 is mainly by inside it
Single-chip microcomputer in injection procedure and rapping program, control sample introduction frequency and rapping frequency.According to Powder aerosol in exposure chamber
The settlement law of concentration requirement and particulate matter, by calculating and debugging, obtains the corresponding injection procedure of each concentration gradient and rapping
Program, in download program to the microcomputer control unit 15 that will be obtained, you can operationally select different aerosol concentrations corresponding
Program.
Sprayer 29 includes inner sleeve 32, sheath tracheae 33.Sprayer 29 is using double gas circuit structures, air-flow details such as Fig. 9 institutes
Show：Compressed air from diffusive gas flow pipeline 8 into sprayer 29 after be divided into two-way, the bottom of medicine bottle 30 is opened below into all the way, by powder
Shape medicine 34 blows afloat, and forms high concentration Powder aerosol, is sprayed outward from inner sleeve 32；Another road air-flow from top sheath tracheae 33 around
Cross, parcel sheath gas 35 is formed in the outside of inner sleeve 32.Sheath gas 35 is mixed airflow with the powdered drug composition that inner sleeve 32 is sent out
36 send out outward, travel further into opposite-flushing type and mix room 11.Being designed with for sheath gas 35 is beneficial to prevent Powder aerosol sample channel
10 block.The present invention can be used to solve the accumulation agglomeration problems of lazy flow powder, it is ensured that the stability of sprinkling.
In the implementation, opposite-flushing type mixes room 11 and is fixed on the top of exposure chamber 2 by flange (shimming sealing), both
Inside is connection, and as shown in Figure 10, opposite-flushing type mixes room 11 has mixing chamber 37, mixes chamber 37 and is communicated with exposure chamber 2, dust
The mouth of pipe of aerosol sample channel 10 is located at the middle for mixing chamber 37, and phase up and down with the mouth of pipe of dilution air flow pipeline 12 that liquidates
It is in the same size to, internal diameter.
Clean gas flow into powder diffuser 7, will be stored in sample successively through diffusive gas flow pipeline 8 and magnetic valve 28
Solid tested material powder diffusion in bottle 30, then by Powder aerosol sample channel 10 and the dilution air flow pipeline 12 that liquidates
Clean gas mix chamber 37 in carry out opposite-flushing type dilution diffusion.
The operational factor of the oral nasal inhalation contamination device of Powder aerosol dynamic formula of the invention is adjusted by microcomputer control unit 15
Control, running status and supplemental characteristic are shown by parameter display unit 16；
Present invention also offers a kind of control method of the oral nasal inhalation contamination device of Powder aerosol dynamic formula, its specific bag
Include：
The general supply of step 1, opening at microcomputer control unit 15, now microcomputer control unit 15, parameter display is single
Unit 16 and blower fan 14 are in energization operating condition, and the program of microcomputer control unit 15 is set into " standby " pattern, then according to
The parameter of display, sets the compressor flow of requirement of experiment；The power supply and its air delivery valve of air compressor 6 are opened, and output is set
Air pressure.
Step 2, it is under " standby " mode state in equipment, removes the dress sample bottle on powder diffuser 7, will be appropriate
After powdered samples load dress sample bottle, then install back on powder diffuser 7；Selection to be run at microcomputer control unit 15
After injection procedure, the property according to given the test agent powder chooses whether to run rapping apparatus 9；Now, contamination equipment start according to
The corresponding parameter operation of target exposure concentration.
" cleaning " program of operation microcomputer control unit 15 before step 3, shutdown, after the operation of this program is finished, closes empty
Air compressor 6 and its air delivery valve, finally close general supply.
All operational factors of the present apparatus show in parameter display unit 16, and operational factor is arranged on microcomputer control unit
It is configured at 15.After selecting a certain program to run, powder diffuser 7 quantitatively sends out powdered samples, then molten through dust gas
Glue sample channel 10 enters opposite-flushing type and mixes room 11, and powdered samples are in the mixing room 11 that liquidates and after the dilution air flow effect that liquidates
Powder aerosol is formed, exposure chamber 2 is subsequently entered.Experimental animal is placed in fixing device for experimental animal 4, fixing device for experimental animal
4 are placed on supporting support 5, and the snoot of animal stretches out the front end circular hole of fixing device for experimental animal 4 exposed to exposure chamber 2
In, complete exposure purpose.Required clean gas flow is provided by air compressor 6 during plant running, the tail gas that experimentation is produced
Through the purified treatment heel row of exhaust purifier 13 to laboratory ventilation system.
Additionally, the present invention is in addition to for the oral nasal inhalation exposure exposure experiment of Powder aerosol dynamic formula, it may also be used for liquid
The oral nasal inhalation exposure exposure experiment of aerosol dynamic formula, room 11 is mixed by the powder diffuser 7 in Fig. 1 and its connection opposite-flushing type
Sample feeding pipe, is replaced as liquid atomiser (liquid aersol generator) and its supporting sample feeding pipe, by adjust air-flow pressure,
The control parameters such as flow, sprinkling frequency, ventilation rate, reach the control to tested material concentration in dosage and exposure chamber.
Although being described in detail to principle of the invention above in conjunction with the preferred embodiments of the present invention, this area skill
Art personnel are not wrapped to the present invention it should be understood that above-described embodiment is only the explanation to exemplary implementation of the invention
Restriction containing scope.Details in embodiment is simultaneously not meant to limit the scope of the invention, without departing substantially from spirit of the invention and
In the case of scope, any equivalent transformation based on technical solution of the present invention, simple replacement etc. are obvious to be changed, and is all fallen within
Within the scope of the present invention.
Claims (7)
1. the oral nasal inhalation contamination device of a kind of Powder aerosol dynamic formula, it is characterised in that the contamination device includes exposure chamber
(2), fixing device for experimental animal (4), air compressor (6), powder diffuser (7), diffusive gas flow pipeline (8), rapping apparatus
(9), dust aerosol sample channel (10), opposite-flushing type mix room (11), the dilution air flow that liquidates pipeline (12), blower fan (14), micro-
Machine control unit (15)；
The air compressor (6) is connected by the diffusive gas flow pipeline (8) with the powder diffuser (7),
The powder diffuser (7) fills for solving quantitative sprinkling and the diffusion problem of solid tested material powder with the rapping
Put (9) to be connected by vertical axle, the rapping apparatus (9) is disintegrated upright accumulation and the caking phenomenon of powder by rapping,
So as to ensure the quantitative control of the powder diffuser (7), the powder diffuser (7) is by the dust aerosol sample feeding pipe
Road (10) is connected to the opposite-flushing type and mixes room (11),
The opposite-flushing type mixes the top that room (11) are fixed on the exposure chamber (2), the opposite-flushing type mix room (11) with it is described
Connection inside exposure chamber (2), the opposite-flushing type mixes room (11) by dilution air flow pipeline (12) and the air of liquidating
Compressor (6) is connected,
The four the week side of boss walls around the exposure chamber (2) are provided with exposure chamber interface (3), the front end of the fixing device for experimental animal (4)
It is connected with the exposure chamber (2) by the exposure chamber interface (3),
The bottom of the exposure chamber (2) is connected by pipeline with the blower fan (14),
The microcomputer control unit (15) is for regulating and controlling the operational factor of the contamination device；
The powder diffuser (7) includes magnetic valve (28), sprayer (29), medicine bottle (30), and the diffusive gas flow pipeline (8) is worn
The magnetic valve (28) is crossed to be connected with the sprayer (29)；The medicine bottle (30) is fixed on the spray by screw thread and sealing gasket
On day with fog (29)；The sprayer (29) mixes room (11) by the Powder aerosol sample channel (10) with the opposite-flushing type
Connection, sends certain density Powder aerosol into the opposite-flushing type and mixes room (11)；The microcomputer control unit (15) passes through
Data wire (31) is connected with the magnetic valve (28)；
The sprayer (29) includes inner sleeve (32), sheath tracheae (33), and the sprayer (29) is using double gas circuit structures, compression
Air is divided into two-way after entering the sprayer (29) from the diffusive gas flow pipeline (8), and the medicine bottle is opened below into all the way
(30) bottom, powdered drug (34) is blown afloat, and is sprayed outward from the inner sleeve (32)；Another road air-flow is from sheath tracheae described in top
(33) bypass, parcel sheath gas (35) is formed in the inner sleeve (32) outside；The sheath gas (35) is sent with the inner sleeve (32)
The powdered drug composition for going out is sent out outward for mixed airflow (36), travels further into opposite-flushing type and mixes room (11).
2. the oral nasal inhalation contamination device of Powder aerosol dynamic formula according to claim 1, it is characterised in that the contamination
Device also include main cabinet (1), exhaust purifier (13), parameter display unit (16), the main cabinet (1) with base plate, in
Layer dividing plate, top board, four columns, the air compressor (6) is placed in the main cabinet (1) outward, the powder diffuser (7) with
The rapping apparatus (9) is individually fixed in inside and outside the top of the main cabinet (1)；The exposure chamber (2) is fixed on institute
State on the middle level dividing plate of main cabinet (1)；The exhaust purifier (13), the microcomputer control unit (15) and the parameter show
Unit (16) is fixed on the crossbeam under the middle level dividing plate, and the blower fan (14) is fixed on the base plate of the main cabinet (1),
Four column bottoms assembling universal wheel of the main cabinet (1), the exhaust purifier (13) is by pipeline and the exposure chamber
(2) bottom connection, the parameter display unit (16) is for showing the running status and parameter of the contamination device.
3. the oral nasal inhalation contamination device of Powder aerosol dynamic formula according to claim 1, it is characterised in that the exposure
Room (2) is the barrel-shaped structure of big volume, major diameter, and lower end is connected with taper dust collector, and exposure chamber interface (3) takes mistake
Position layout, the exposure chamber interface (3), can be with occluding member interface equipped with blind plate.
4. the oral nasal inhalation contamination device of Powder aerosol dynamic formula according to claim 1, it is characterised in that the experiment
Animal holder (4) includes movable carriage (17), elastic reducing-fixing band (18), animal accommodation chamber (19), sideboard (20), excrement
Just urine collector (21), the animal accommodation chamber (19) is made of transparent organic glass, and its front end is mutually fitted with animal head
The tapered conical bucket answered；The main part of the animal accommodation chamber (19) is barrel-shaped cylinder, and there is difference its top and bottom
The open slot of width, open top groove is used for the movement and fixation of the sideboard (20), and the open slot of bottom is easy to animal
The excrement urine of excretion enters the excrement urine collector (21) being connected with the animal accommodation chamber (19), and the animal is held
Receiving the bottom in cabin (19) is equipped with the latch (22) supporting with excrement urine collector (21) upper groove, by the groove and
The latch (22) coordinates, and facilitates the installation and disassembly, cleaning of the excrement urine collector (21)；The sideboard (20)
By can be elastic nut and constitute with certain thickness circular baffle plate, have and animal buttocks phase inside the circular baffle plate of its configuration
The curved surface of adaptation and can allow animal tail through the sideboard (20) circular hole (23)；
The contamination device also includes first support (5), and the movable carriage (17) is placed in the corresponding of the first support (5)
At position, the main body of the fixing device for experimental animal (4) is placed in on the mounted movable carriage (17), with it is described can
The elastic reducing-fixing band (18) configured on movable support bracket (17) is fixed by the fixing device for experimental animal (4).
5. the oral nasal inhalation contamination device of Powder aerosol dynamic formula according to claim 4, it is characterised in that described first
Support (5) is followed successively by by the base of stainless steel substrates material, lower floor, middle level and upper strata from top to bottom, and threaded rod is passed through between each layer
Fixed with nut, the height per layer height with exposure chamber interface (3) is adapted.
6. the oral nasal inhalation contamination device of Powder aerosol dynamic formula according to claim 1, it is characterised in that the rapping
Device (9) includes electromagnet (24), cover plate (25), back-moving spring (26), second support (27), and the cover plate (25) is whole dye
The top board of malicious cabinet, the electromagnet (24) is fixed on the cover plate (25)；The second support (27) be equipped with by it four
Root threaded rod is fixed on the cover plate (25), and the vibrating shaft on the electromagnet (24) is through the cover plate (25) and described the
The circular hole at two supports (27) center is firm with the sprayer (29) to be connected；It is installed with the middle of the back-moving spring (26) and is threaded
Stainless steel shaft, be connected through the circular hole in the second support (27) and the sprayer (29) are firm.
7. the oral nasal inhalation contamination device of Powder aerosol dynamic formula according to claim 1, it is characterised in that described to liquidate
Formula mixes room (11) with chamber (37) are mixed, and the mixing chamber (37) communicates with the exposure chamber (2), and the dust aerosol enters
The mouth of pipe of sample pipeline (10) with it is described liquidate dilution air flow pipeline (12) mouth of pipe positioned at the mixing chamber (37) middle, and on
Lower relative, internal diameter is in the same size.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610541458.7A CN106175975B (en) | 2016-07-11 | 2016-07-11 | A kind of oral nasal inhalation contamination device of Powder aerosol dynamic formula |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610541458.7A CN106175975B (en) | 2016-07-11 | 2016-07-11 | A kind of oral nasal inhalation contamination device of Powder aerosol dynamic formula |
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| CN106175975A CN106175975A (en) | 2016-12-07 |
| CN106175975B true CN106175975B (en) | 2017-07-04 |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109512541A (en) * | 2017-09-19 | 2019-03-26 | 中国人民解放军军事科学院军事医学研究院微生物流行病研究所 | Medium and small animal organism aerosol mouth and nose exposure system |
| CN110251266B (en) * | 2019-06-25 | 2021-06-04 | 中国人民解放军陆军军医大学 | Rat noise and carbon monoxide integrated combined exposure contamination experimental device |
| CN112875047A (en) * | 2021-01-12 | 2021-06-01 | 辽宁科技学院 | Component detection kit applied to chemical drugs |
| WO2022178752A1 (en) * | 2021-02-25 | 2022-09-01 | 中国科学院生态环境研究中心 | Expiratory metabolism measurement system |
| CN113768657B (en) * | 2021-10-12 | 2024-05-10 | 兵器工业卫生研究所 | Exposure device for gas inhalation contamination experiment |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4520808A (en) * | 1983-03-10 | 1985-06-04 | Stauffer Chemical Company | Inhalation exposure apparatus |
| CN100490761C (en) * | 2006-02-17 | 2009-05-27 | 范维林 | Dynamic inhalational contamination experimental instrument with solid-phase dust |
| JP2007232453A (en) * | 2006-02-28 | 2007-09-13 | Sumitomo Chemical Co Ltd | Inhalation toxicity tester and inhalation toxicity testing method |
| CN202128563U (en) * | 2011-07-06 | 2012-02-01 | 天津开发区合普工贸有限公司 | Rodent only-nasal type inhalation toxicity exposure test device |
| CN203029422U (en) * | 2012-12-20 | 2013-07-03 | 中国人民解放军第三军医大学 | Infection concentration tank and rat mouth-nose infection concentration tank |
| CN203370537U (en) * | 2013-07-23 | 2014-01-01 | 公安部天津消防研究所 | Ultrafine powder body aerosol continuous generation device |
| CN104367398A (en) * | 2013-08-13 | 2015-02-25 | 北京慧荣和科技有限公司 | Whole body exposure system for animals |
| CN104374928B (en) * | 2013-08-13 | 2018-06-01 | 北京慧荣和科技有限公司 | More concentration animal mouth and nose suck dynamic exposure device |
| CN105092786A (en) * | 2015-07-23 | 2015-11-25 | 上海化工研究院 | Oppositely-impacting quantitative atomization drug delivery apparatus |
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