CN104374928B - More concentration animal mouth and nose suck dynamic exposure device - Google Patents
More concentration animal mouth and nose suck dynamic exposure device Download PDFInfo
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- CN104374928B CN104374928B CN201310351055.2A CN201310351055A CN104374928B CN 104374928 B CN104374928 B CN 104374928B CN 201310351055 A CN201310351055 A CN 201310351055A CN 104374928 B CN104374928 B CN 104374928B
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Abstract
The invention discloses a kind of more concentration animal mouth and nose sucking dynamic exposure devices, including air compressor, aerosol generating system, mouth and nose exposure unit and waste gas reclamation treatment system；Mouth and nose exposure unit includes experimental group exposure chamber；The aerosol import connection of aerosol generating system and experimental group exposure chamber；The waste gas outlet of experimental group exposure chamber is connected with waste gas reclamation treatment system；Wherein, multi-concentration dilution system is further included；Experimental group exposure chamber includes more piece and tests exposure chamber；Multi-concentration dilution system includes the 3rd air flow controller of the air inlet amount in the second aerosol diluter of the second aerosol diluter and control being arranged between each section experiment exposure chamber.By the second aerosol diluter being arranged between each section experiment exposure chamber, it is diluted to entering the second section experiment exposure indoor aerosols by first segment experiment exposure chamber, to meet the requirement of experiment, also allows for the comparison tested under various concentration.
Description
Technical field
It is sudden and violent more particularly to a kind of more concentration animal mouth and nose sucking dynamics the present invention relates to animal sucking toxicological experiment field
Reveal equipment.It is various available for sucking toxicity Drug safety assessment, pesticide acute toxicity sucking experimental study, structure animal COPD
Disease model and its curative effect of medication experimental study, atmosphere pollution are to research of animal breath systematic influence etc..
Background technology
At present, in sucking in the relevant various scientific researches of toxicity, particularly some are to human health harmful substance
Research, such as PM2.5, due to that cannot cannot test directly or to the mankind first, thus often will using experimental animal into
Row sucking Exposure Assessment.Therefore, animal exposing device has in industry, agricultural, medicine, environmental pollution and military science research
It is widely applied.EXPERIMENT STUDY ON SUBCHRONIC or the evaluation of a kind of substance are completed, generally requires the animal exposure for carrying out multiple dosage
Experiment.Animal exposing device of the prior art is all single concentration, i.e., once experiment can only carry out the animal of a dosage group
Exposure will carry out the animal exposure test of multiple dosage groups, it is necessary to utilize more set animal exposing devices or passed through with set of device
Many experiments could be completed, it is impossible to realize and be carried out at the same time more concentration zooperies in same set of sucking exposing device and compare
Analysis.
Therefore there is following deficiency：In the prior art can not simultaneously in same experimental facilities and at various concentrations into
Object of taking action sucks toxicological experiment.
The content of the invention
The purpose of the embodiment of the present invention is to provide a kind of more concentration animal mouth and nose sucking dynamic exposure devices, solves existing
The problem of can not carrying out animal sucking toxicological experiment in technology in same experimental facilities and at various concentrations simultaneously.
To achieve these goals, the present invention provides a kind of more concentration animal mouth and nose to suck dynamic exposure devices, including
For providing the air compressor of compressed air, aerosol generating system, mouth and nose exposure unit and waste gas reclamation treatment system；
The mouth and nose exposure unit includes experimental group exposure chamber and fixing device for experimental animal；The aerosol generating system includes aerosol
Generator, for control the air inlet amount in the aerosol generator the first air flow controller, for described
It is dilute that aerosol generator provides the medicinal liquid bottle of liquid, the first aerosol being connected with the aerosol outlet of the aerosol generator
Release device and the second air flow controller for controlling the air inlet amount in first aerosol diluter；Described first
Aerosol diluter is connected with the aerosol import of the experimental group exposure chamber；The waste gas outlet of the experimental group exposure chamber and institute
State waste gas reclamation treatment system connection；Wherein,
Further include multi-concentration dilution system；The experimental group exposure chamber includes more piece and tests exposure chamber；More concentration dilution systems
System is included in the second aerosol diluter of the second aerosol diluter and control being arranged between each section experiment exposure chamber
Air inlet amount the 3rd air flow controller.
Preferably, the waste gas reclamation treatment system includes the waste gas recovery case, device for drying and filtering, waste gas stream being sequentially connected
Amount controller, manual ball valve, vacuum pump and high altitude discharge processing system)；The waste gas recovery case is connected with the waste gas outlet
It is logical.
Preferably, the mouth and nose exposure unit further includes oxygen concentration sensor, pressure sensor, temperature sensor and wet
Spend sensor and sampling of aerosol pipe, the oxygen concentration sensor, the pressure sensor, the temperature sensor, institute
It states humidity sensor and the sampling of aerosol pipe is arranged in each section experiment exposure chamber.
Preferably, security mask cabinet and vacuum tiny structure processing system are further included；
The security mask cabinet includes animal behavior remote monitoring camera, headlamp, ultraviolet disinfection lamp, USB communications
Interface and the thief hatch for gathering aerosol sample；
The vacuum tiny structure processing system be used to preventing the aerosol of a small amount of leakage in the security mask cabinet into
Enter air, the vacuum tiny structure processing system includes check valve, differential pressure indicator and vacuum pump.
Preferably, sampling system and control system are further included.
Preferably, the sampling system include be sequentially connected the two-position two-way solenoid valve connect, aerosol concentration monitor and
Aerosol flow controller and vacuum pump；The two-position two-way solenoid valve is connected with the sampling of aerosol pipe.
Preferably, the control system include industrial PC, touch screen computer, software programming control terminal, data collecting card,
Relay control panel, contactor and RS485 communication interfaces；
The contactor, the relay control panel, the data collecting card and the industrial PC are sequentially connected, described
RS485 communication interfaces connect the industrial PC, and the software programming control terminal connects the industrial PC, the touch screen electricity
Brain connects the industrial PC.
Preferably, the mouth and nose exposure unit further includes control group exposure chamber.
Preferably, the more piece experiment exposure chamber tests exposure chamber or four section experiment exposure chambers for three sections or five section experiments are sudden and violent
Reveal room.
Preferably, second aerosol diluter is set in the aerosol entrance.
At least there are following technique effects for the embodiment of the present invention：
1) the second aerosol of the second aerosol diluter and control by being arranged between each section experiment exposure chamber
3rd air flow controller of the air inlet amount in diluter, to entering the experiment of the second section by first segment experiment exposure chamber
Exposure indoor aerosols are diluted, and to meet the requirement of experiment, also allow for the comparison tested under various concentration.
2) by setting sampling system and control system, the degree of automation and control accuracy of the equipment are improved.
3) by setting waste gas reclamation treatment system and security mask cabinet and vacuum tiny structure processing system, poison can be prevented
Gas is revealed, and eliminates the pollution to operating personnel, improves security and the precision of contamination.
4) aerosol generated from aerosol generator can be used for multiple experiments simultaneously, and be used continuously, and save gas
Colloidal sol usage amount improves the utilization rate of aerosol.
5) aerosol generated using an aerosol generator prevents that traditional more concentration are real simultaneously for multiple experiments
It is bigger to test the middle systematic error generated using multiple aerosol generators, equipment is complicated, bulky etc..
6) multiple experiments are carried out at the same time, experimental efficiency is high, and the time is short.
According to the accompanying drawings to the detailed description of the specific embodiment of the invention, those skilled in the art will be brighter
The above and other objects, advantages and features of the present invention.
Description of the drawings
Some specific embodiments of detailed description of the present invention by way of example, and not by way of limitation with reference to the accompanying drawings hereinafter.
Identical reference numeral denotes same or similar component or part in attached drawing.It should be appreciated by those skilled in the art that these
What attached drawing was not necessarily drawn to scale.In attached drawing：
Fig. 1 is the structure diagram of the embodiment of the present invention；
Fig. 2 is the detailed construction schematic diagram of the embodiment of the present invention；
Fig. 3 is the sectional view of the mouth and nose exposure unit of the embodiment of the present invention；
Fig. 4 is the structure diagram of the second aerosol diluter of the embodiment of the present invention；
Fig. 5 is the sectional view of another mouth and nose exposure unit of the embodiment of the present invention；
Fig. 6 is the structure diagram of the second aerosol diluter of another kind of the embodiment of the present invention；
Reference numeral：Air compressor 111, aerosol generating system 1, air flow control valve 19, aerosol generator
11, the first aerosol diluter 12, medicinal liquid bottle 13, the first air flow controller 17, the second air flow controller 16, control
System 2, industrial PC 21, touch screen computer 22, software programming control terminal 23, data collecting card 24, relay control panel 25 connect
Tentaculum 26, RS485 communication interfaces 27, sampling system 3, two-position two-way solenoid valve 31, aerosol concentration monitor 32, aerosol stream
Amount controller 35, vacuum tiny structure processing system 5, check valve 51, differential pressure indicator 52, mouth and nose exposure unit 6, control group exposure chamber
61, fixing device for experimental animal 62, experimental group exposure chamber 63, first segment experiment exposure chamber 110, the second section experiment exposure chamber 120, the
Three section experiment exposure chambers 130, inner cylinder 101, outer barrel 102, aerosol import 112, stomata 631, connecting tube 65, the 4th air mass flow
Controller 68, multi-concentration dilution system 7, Dilution air device 71, the 3rd air flow controller 72, the second aerosol diluter
73, the first air inlet of gas 41, gas inlet pipe 42, venthole 43, first gas static pressure chamber 44, static pressure chamber outlet 45, forepart
Component 46, middle member 47, back member 48, the first matter inlet 401, gas feed 402, the second matter inlet 403, second
Gas-static chamber 405 mixes ejector pipe 406, mixing chamber 407, compounding substances outlet 408, security mask cabinet 8, animal behavior
Remote monitoring camera 81, headlamp 82, ultraviolet disinfection lamp 83, USB communication interfaces 84, thief hatch 85, waste gas recovery processing
System 9, waste gas recovery case 91, device for drying and filtering 92, exhaust gas flow controller 93, manual ball valve 94, high altitude discharge processing system
96。
Specific embodiment
To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below in conjunction with attached drawing to specific real
Example is applied to be described in detail.
As depicted in figs. 1 and 2, more concentration animal mouth and nose sucking dynamic exposure devices, including being used to provide compressed air
Air compressor 111, aerosol generating system 1, mouth and nose exposure unit 6 and waste gas reclamation treatment system 9；In air compressor
111 exit is provided with air flow control valve 19；Mouth and nose exposure unit 6 includes experimental group exposure chamber 63 and experimental animal is consolidated
Determine device 62；Aerosol generating system 1 includes aerosol generator 11, for controlling the air inlet amount in aerosol generator 11
The first air flow controller 17, for aerosol generator 11 provide liquid medicinal liquid bottle 13 and aerosol generator
The first aerosol diluter 12 that 11 aerosol outlet is connected and for control the air in the first aerosol diluter 12 into
Second air flow controller 16 of tolerance；First aerosol diluter 12 and the aerosol import 112 of experimental group exposure chamber 63
Connection；The waste gas outlet of experimental group exposure chamber 63 is connected with waste gas reclamation treatment system 9；Wherein, more concentration dilution systems are further included
System 7；Experimental group exposure chamber 63 includes more piece and tests exposure chamber, tests exposure chamber as experimental group exposure chamber 63 includes three sections, respectively
The section of exposure chamber 110, second experiment exposure chamber 120 and Section of three experiment exposure chamber 130 are tested for first segment；It can also include four sections
Test exposure chamber or five section experiment exposure chambers.Multi-concentration dilution system 7 includes be arranged between each section experiment exposure chamber second
3rd air flow controller 72 of the air inlet amount in the second aerosol diluter 73 of aerosol diluter 73 and control, such as
Second aerosol diluter 73 is set between the first segment experiment section experiment exposure chamber 120 of exposure chamber 110 and second, in the second section
Second aerosol diluter 73 is set between experiment exposure chamber 120 and Section of three experiment exposure chamber 130, it can also be real in first segment
The entrance for testing exposure chamber 110 sets the second aerosol diluter 73.Fixing device for experimental animal 62 installs each section experiment exposure chamber
Periphery, animal is mounted in fixing device for experimental animal 62, absorbs the indoor aerosol of exposure by connecting tube 65, generation it is useless
Gas and the extra aerosol being inhaled into are recycled and handled by waste gas reclamation treatment system 9.
Exposure chamber includes inner cylinder 101 and outer barrel 102；The first end of inner cylinder 101 is provided with aerosol import 112, inner cylinder 101
Second end closing, in order to convenient for cleaning, be provided with aperture after testing in the second end bottom of inner cylinder 101, with stifled during experiment
Head blocks, and closes the second end of inner cylinder 101；The first end closing of outer barrel 102, the second end of outer barrel 102 are provided with exhaust gas and go out
Mouthful, waste gas outlet is multiple ventholes；The connecting tube 65 being connected with fixing device for experimental animal 62 is provided on inner cylinder 101；Outside
Cylinder 102 is connected with fixing device for experimental animal 62, can be by animal mouth and nose respiratory siphon being set to be connected or in connecting tube
65 are connected with the gap set at the mouth wall of fixator connector.Exposure chamber includes experimental group exposure chamber 63 and control group exposes
Room 61.
It can be seen that in the embodiment of the present invention, the first via compressed air that air compressor 111 generates enters aerosol hair
In raw device 11, liquid, which is entered from medicinal liquid bottle 13 in aerosol generator 11, maintains the liquid level of 11 the inside of aerosol generator high
It spends constant, so as to generate high concentration and the good aerosol of stability of concentration, reaches 98% below 5 μm of aerosol particle, into
Enter into the first aerosol diluter 12, generated afterwards with the air compressor 111 entered through the second air flow controller 16
The first segment that experimental group exposure chamber 63 is entered from aerosol import 112 after second tunnel compressed air mixed diluting tests exposure chamber
In 110 inner cylinder, the concentration that aerosol dilution is contaminated to needs, it can ensure that experimental animal can be more preferable in this case
Carry out toxicological experiment, a part of aerosol is arranged on the fixing device for experimental animal 62 of first segment experiment exposure chamber 110 periphery
In animal absorb after discharge after, entered from fixing device for experimental animal 62 in the outer barrel 102 of experimental group exposure chamber 63, pass through
The waste gas outlet that the second end of outer barrel 102 is set, enters waste gas reclamation treatment system 9, and first segment is tested in exposure chamber 110
Another part aerosol enters the after the second aerosol diluter 73 dilution between being arranged on each section experiment exposure chamber
In the inner cylinder of two section experiment exposure chambers 120, the 3rd tunnel compressed air that air compressor 111 generates is by the second aerosol of control
3rd air flow controller 72 of the air inlet amount in diluter 73 is entered in the second aerosol diluter 73 for dilute
The aerosol that will be entered in the second section experiment exposure chamber 120 is released, the second section tests a part of aerosol in exposure chamber 120
After the animal being arranged in the fixing device for experimental animal 62 of 120 periphery of the second section experiment exposure chamber is discharged after absorbing, from experiment
It is entered in animal holder 62 in the outer barrel 102 of experimental group exposure chamber 63, the exhaust gas set by the second end of outer barrel 102 goes out
Mouthful, enter waste gas reclamation treatment system 9.By same mode, another part gas in the second section experiment exposure chamber 120 is molten
Glue is entered in Section of three experiment exposure chamber 130.
Therefore, the embodiment of the present invention can realize the animal sucking toxicological experiment under various concentration in same equipment.Energy
Enough realize is realized animal is tested under more concentration levels and comparative analysis simultaneously.
Meanwhile mouth and nose exposure unit 6 further includes control group exposure chamber 61, set control group purpose be that by with just
Animal under the conditions of being frequently grown is compared, and the 4th tunnel compressed air that air compressor 111 generates passes through the 4th air mass flow
Controller 68 enters control group exposure chamber 61, and animal absorbs check plot by connecting tube 65 and exposes indoor air, generation
Exhaust gas and the extra air being inhaled into are recycled and handled by waste gas reclamation treatment system 9.
Waste gas reclamation treatment system 9 includes waste gas recovery case 91, device for drying and filtering 92, the exhaust gas flow control being sequentially connected
Device 93, manual ball valve 94, vacuum pump and high altitude discharge processing system 96.Waste gas recovery case 91 is for recycling exhaust gas, with exposure chamber
Outer barrel 102 second end set waste gas outlet be connected.In the present embodiment, waste gas reclamation treatment system 9 is two, point
The exhaust gas in experimental group exposure chamber 63 and control group exposure chamber 61 Yong Yu not handled.
Mouth and nose exposure unit 6 further include oxygen concentration sensor, pressure sensor, temperature sensor and humidity sensor with
And sampling of aerosol pipe, it is arranged in each section experiment exposure chamber, for detecting the indoor oxygen concentration of each section experiment exposure, pressure
Power, temperature and humidity and aerosol concentration.
In another embodiment of the presently claimed invention, more concentration animal mouth and nose sucking dynamic exposure devices further include protective screen
Cover cabinet 8 and vacuum tiny structure processing system 5.Security mask cabinet 8 include animal behavior remote monitoring camera 81, headlamp 82,
Ultraviolet disinfection lamp 83, USB communication interfaces 84 and the thief hatch 85 for gathering aerosol sample.Vacuum tiny structure processing system
5 are used to prevent the aerosol of a small amount of leakage in security mask cabinet 8 from entering air；Vacuum tiny structure processing system 5 includes single
To valve 51, differential pressure indicator 52 and vacuum pump.
In another embodiment of the presently claimed invention, more concentration animal mouth and nose sucking dynamic exposure devices further include sampling system
System 3 and control system 2.
Sampling system 3 includes being sequentially connected the two-position two-way solenoid valve 31 connect, aerosol concentration monitor 32 and aerosol
Flow controller 35 and vacuum pump.Two-position two-way solenoid valve 31 is connected with sampling of aerosol pipe.Aerosol concentration monitor
32 be the core component of sampling system, can the indoor aerosol concentration of each section experiment exposure is monitored and be sampled in real time point
Analysis, to draw experimental data and response curve, to show that experiment conclusion provides good condition.
Control system 2 include industrial PC 21, touch screen computer 22, software programming control terminal 23, data collecting card 24, after
Appliance controling plate 25, contactor 26 and RS485 communication interfaces 27；For collecting various parameters, and set according to these state modulators
The concentration of each component working and each section exposure indoor aerosols of control in standby, makes equipment meet the requirement of experiment.
Industrial PC 21, lower contact relay control panel 25, the connection contact of relay control panel 25 are connect on data collecting card 24
Device 26, contactor 26 are used to control being turned on or off for all vacuum pumps and air compressor 111.Oxygen concentration sensor,
Pressure sensor, temperature sensor and humidity sensor are connected with data collecting card 24.First air flow controller 17, second
Air flow controller 16, the 3rd air flow controller 72, the 4th air flow controller 68, exhaust gas flow controller 93,
Aerosol flow controller 35 and two-position two-way solenoid valve 31 are all connected with RS485 communication interfaces 27, and RS485 communication interfaces 27 connect
Then industrial PC 21 write program to each control hardware terminal from software programming control terminal 23 and send corresponding life
Order, ensure that the precision of experiment.With automatic control system, high degree of automation, experimental precision is high.
In use, first carrying out thorough disinfection to security mask cabinet 8 with ultraviolet disinfecting 83, experiment liquid is placed into medicinal liquid bottle
In 13, opening control 2 is configured experiment parameter, including medicinal liquid flow, the first air mass flow, the second air mass flow,
3rd air mass flow, the 4th air mass flow, exhaust gas flow, aerosol flow and negative pressure value etc., after setting completed by experimental animal
It is put into fixing device for experimental animal 62, opens vacuum tiny structure processing system 5, then click on the start button in industrial PC 21
Order contamination starts.Aerosol is generated by aerosol generating system 1 and enters experimental group exposure chamber 63.Control group exposure chamber 61 will be logical
Enter a certain amount of compressed air to carry out real-time sampling comparison with the experimental group exposure chamber 63 for being passed through aerosol.Sampling system 3 is right
The indoor aerosol of each section experiment exposure in experimental group exposure chamber 63 is sampled and obtains the concentration feedback of aerosol to controlling
System 2 processed.Oxygen concentration sensor in each section experiment exposure chamber, pressure sensor, temperature sensor and humidity sensor are adopted
The information collected constantly feeds back to control system 2.Control system 2 is according to the indoor oxygen concentration of each section experiment exposure, pressure, temperature
Degree and humidity and aerosol concentration are adjusted to entering the indoor air capacity of section experiment exposure.Exhaust gas in experiment can
It filters and discharges by waste gas reclamation treatment system 9.When finishing, industrial PC 21 can generate experimental diagrams for experiment, for client into
Row analysis.Unlatching, the control of whole process can be completed with operation regulation and control in software programming control terminal 23, be realized full-automatic
Change monitoring and operation, make experiment more easy to operate, safety.More concentration animal mouth and nose sucking dynamic exposure devices, which generate, meets particle
The aerosol of size and concentration and concentration can be uniformly distributed, in each layer in each section of experimental group exposure chamber 63 how dense
It spends under the auxiliary of dilution system 7, each layer of aerosol concentration is different.Full-automation monitoring is with controlling, possessing at waste gas recovery
Reason system 9；It can prevent mouth and nose that poison gas reveals, powerful more concentration can be sampled in time, multi-functional from sucking dynamically
Exposure device.It is easy to operate, the pollution to operating personnel is eliminated, improves security and the precision of contamination.
According to the present invention, in another embodiment of the present invention, as shown in figure 3, mouth and nose exposure unit 6 further includes exposure
Unit base.Second aerosol diluter 73 is arranged in inner cylinder 101；Waste gas outlet is by being arranged on gas on exposure unit pedestal
Hole 631 is connected with waste gas reclamation treatment system 9；Sampling of aerosol pipe is arranged on inner cylinder 101, and gas is also set up on inner cylinder 101
Body inlet pipe.Gas inlet pipe is diluted aerosol, for being passed through air into the second aerosol diluter 73 on gas inlet pipe
It is provided with the 3rd air flow controller 72 and Dilution air device 71.
On the outer barrel of the first segment experiment section of exposure chamber 110, second experiment exposure chamber 120 and Section of three experiment exposure chamber 130
12 fixing device for experimental animal being disposed on the same plane 62 are both provided with, are tested by first segment in exposure chamber 110
The second aerosol diluter set at the connecting tube of cylinder and between the connecting tube of the inner cylinder of the second section experiment exposure chamber 120
73, make to enter the concentration even circumferential distribution of the aerosol at the connecting tube 65 of the inner cylinder of the second section experiment exposure chamber 120,
The concentration of aerosol is the same at the mouth of connecting tube 65, i.e., the concentration of indoor each layer of same circumferential location is exposed in the section
It is consistent, it is ensured that the concentration that each animal is drawn into mouth and nose is consistent；The indoor aerosol of each section experiment exposure
Concentration is the same, and the concentration before and after only the second aerosol diluter is different, i.e. the indoor aerosol of each section experiment exposure
Concentration it is inconsistent, if a part of aerosol in the indoor aerosol of first segment experiment exposure is absorbed by animal, remaining gas
Colloidal sol continues to flow downward, and is entered after the second aerosol diluter in the second section experiment exposure chamber.It is molten by changing gas
The ratio of glue and diluent gas can obtain different diluted concentrations.Following table show more concentration animal mouth and nose sucking dynamics
Concentration distribution (the unit in every section exposure chamber that exposure device is obtained by adjusting certain diluting gas flow：Milligram
Every cubic metre)：
| Interface | 1 | 2 | 3 | 4 | 5 | 6 |
| First segment | 4950 | 4930 | 4870 | 4860 | 5100 | 5090 |
| Second section | 985 | 993 | 971 | 985 | 1021 | 1012 |
| Section three, | 197 | 201 | 197 | 195 | 196 | 187 |
| Interface | 7 | 8 | 9 | 10 | 11 | 12 |
| First segment | 5060 | 4930 | 4970 | 4780 | 4860 | 4920 |
| Second section | 987 | 1020 | 978 | 975 | 983 | 987 |
| Section three, | 193 | 189 | 205 | 196 | 203 | 207 |
As seen from the above table, the dilution effect of more concentration animal mouth and nose sucking dynamic exposure devices is relatively good, after dilution
Often the section indoor aerosol concentration of exposure is convenient for contrast experiment than more uniform.
As shown in figure 4, a kind of second aerosol diluter 73 includes mixing ejector pipe 406 and mixing chamber 407, injection is mixed
The first end of pipe 406 is the first matter inlet 401, and the second end of mixing ejector pipe 406 is connected with mixing chamber 407；Wherein, also
Including the second matter inlet 403, the second matter inlet 403 be arranged on mixing ejector pipe 406 tube wall on gap, gap by
The first face and the second face being mutually parallel are formed.First face is circular conical surface, and circular conical surface is coaxial with mixing ejector pipe 406.Gap exists
It is tilted on the flow direction of second substance towards the direction of mixing chamber 407.Mixing chamber 407 includes being connected with mixing ejector pipe 406
Logical first end cone-shaped cavity, the cylindrical chamber of interlude and second end cone-shaped cavity, the end of second end cone-shaped cavity opens up
There is compounding substances outlet 408.First substance is aerosol, and the second substance is air.By setting gap-shaped gas-solvent
Import makes air inlet evenly, and more stable, dilution effect is more preferable.By setting the direction of the second matter inlet, make gap both ends
Differential pressure action makes gas-solvent enter in mixing chamber, and such setting can prevent the first substance or the second substance from flowing backwards, and influence to dilute
Efficiency.By the thin mixing chamber in thick both ends among setting, vortex is formed in mixing chamber, further makes mixing evenly.Gap
Width it is adjustable, the width adjusting scope in gap is 0-6mm.Specifically, mixing ejector pipe 406 is divided into first portion by gap
And second portion, it is connected through a screw thread between first portion and second portion.By setting the adjustable of gap width, to adjust
Two substance inlets, convenient for being applied to a variety of occasions, a variety of diluted concentrations.It can also be by controlling air input or gas molten
Glue input quantity adjusts required diluted concentration.After a large number of experimental verification and data simulation analysis, the width in gap exists
Effect between 0-6mm is best, and if more than 6mm, then the effect is relatively poor.Second gas static pressure chamber 405 is further included, second gas is quiet
Gas feed 402 is provided on pressure chamber 405, second gas static pressure chamber 405 is by the second matter inlet 403 with mixing ejector pipe
406 are connected.Second gas static pressure chamber 405 is annular housing, is arranged on the periphery of mixing ejector pipe 406；First matter inlet
401 be tapered opening, and tapered opening is towards the first matter inlet side.By setting second gas static pressure chamber, make the second substance first
Into second gas static pressure, after being uniformly distributed, the second matter inlet is entered back into, the gas-solvent for making entrance evenly, then mixes
It is more preferable to close effect.Mixing ejector pipe 406 includes the first segment ejector pipe set gradually along the flow direction of the first substance and the
Two sections of ejector pipes, the sectional area of first segment ejector pipe are less than the sectional area of second segment ejector pipe, and gap is arranged on second segment injection
On the tube wall of pipe.It can be prevented by such setting, when the first substance flows from the top to the bottom, there are some liquid or suspended particulates
Gap is blocked, that is, blocks the second matter inlet, results in that the equipment can not operate normally.It is coniform unremitting by setting
Gap makes air inlet evenly as gas-solvent import, more stable, and dilution effect is more preferable, concentration after mixing or dilution is stablized,
It is evenly distributed.By setting the direction of the second matter inlet, make the differential pressure action at gap both ends, gas-solvent is made to enter mixing chamber
Interior, such setting can prevent the first substance or the second substance from flowing backwards, and influence dilution efficiency.By setting the adjustable of gap width,
The second substance inlet is adjusted, convenient for being applied to a variety of occasions, a variety of diluted concentrations.It is mixed by the way that thick both ends among setting are thin
Chamber is closed, vortex is formed in mixing chamber, further makes mixing evenly.By setting gas-static chamber, make the second substance advanced
Enter gas-static chamber, gap can make gas generate hydrostatic pressure, after being distributed so as to even circumferential, enter back into the second substance
Import, making the gas-solvent circle distribution of entrance, evenly then mixed effect is more preferable.
Exemplified by connection between the first segment experiment section experiment exposure chamber 120 of exposure chamber 110 and second, first segment experiment is sudden and violent
The inner cylinder bottom of dew room 110 is equipped with the second aerosol diluter 73, and the gas that first segment is tested inside the inner cylinder of exposure chamber 110 is molten
Glue is entered by the first matter inlet 401 in the second aerosol diluter 73, after through mixing matter discharge port 408 enter
In the inner cylinder of second section experiment exposure chamber 120, the 3rd tunnel compressed air that air compressor 111 generates is entered through gas inlet pipe
In gas feed 402 in second aerosol diluter 73.
As shown in Figure 5,6, an embodiment of the present invention provides another 6 and second aerosol diluters 73 of mouth and nose exposure unit
Structure, the second aerosol diluter 73 include front piece 46, middle member 47 and back member 48；It is set in front piece 46
The first air inlet of gas 41 is equipped with, is connected with gas inlet pipe；Second aerosol diluter 73 is installed by gas inlet pipe and fixed
In inner cylinder 101.Cylindricality cavity is offered in the rear end of middle member 47, back member 48 includes covering in cylindricality cavity
The cover board of opening；Cavity between cover board and cylindricality cavity forms first gas static pressure chamber 44, and cover board is opened with cylindricality cavity
Mouthful place plane between there is gap, gap exports 45 for static pressure chamber；Back member 48, which further includes, is vertically set on cover board
Surface on gas inlet pipe 42, be provided with external screw thread, 41 He of the first air inlet of gas on the outer surface of gas inlet pipe 42
It is provided between cylindricality cavity and the matched internal thread through hole of external screw thread；Gas inlet pipe 42 and cylindricality cavity are coaxial, gas
The end of air inlet pipe 42 is evenly arranged with multiple ventholes 43.The aperture of static pressure chamber outlet 45 can pass through gas inlet pipe 42
Screw-in depth is adjusted.Exemplified by connection between the first segment experiment section experiment exposure chamber 120 of exposure chamber 110 and second, the
The inner cylinder bottom of one section experiment exposure chamber 110 is equipped with the second aerosol diluter 73, and first segment tests the inner cylinder of exposure chamber 110
Internal aerosol enters the second section by the gap between the inner wall of front piece 46 and inner cylinder 101 and tests exposure chamber 120
Inner cylinder in, air compressor 111 generate the 3rd tunnel compressed air enter the second aerosol diluter 73 through gas inlet pipe
In the first import of gas 41 in.The outlet of static pressure chamber is that be arranged on the cavity wall of gas-static chamber free of discontinuities with circumference that bottom surface is formed
The gap of adjustable size makes to enter gas at mixing evenly, more stable, mixing or dilution effect is more preferable, mixing
Or the concentration after dilution is stablized, and is evenly distributed.By setting first gas passage in inside, in outside the second substance is set to lead to
Road makes structure simpler, mixing or dilution device volume smaller, more practical.Being connected through a screw thread makes the adjustable of gap width, comes
First gas inlet is adjusted, convenient for being applied to a variety of occasions, a variety of diluted concentrations.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, without departing from the principle of the present invention, any improvements and modifications made also should be regarded as the protection of the present invention
Scope.
Claims (10)
1. a kind of more concentration animal mouth and nose sucking dynamic exposure devices, the air compressor including being used to provide compressed air
(111), aerosol generating system (1), mouth and nose exposure unit (6) and waste gas reclamation treatment system (9)；The mouth and nose exposure is single
First (6) include experimental group exposure chamber (63) and fixing device for experimental animal (62)；The aerosol generating system (1) includes aerosol
Generator (11), the first air flow controller for controlling the air inlet amount in the aerosol generator (11)
(17), for liquid is provided to the aerosol generator (11) medicinal liquid bottle (13), with the aerosol generator (11)
The first aerosol diluter (12) that aerosol outlet is connected and for controlling the sky in first aerosol diluter (12)
The second air flow controller (16) of gas air inflow；First aerosol diluter (12) and the experimental group exposure chamber
(63) aerosol import (112) connection；The waste gas outlet of the experimental group exposure chamber (63) and the waste gas recovery processing system
System (9) connection；It is characterized in that,
Further include multi-concentration dilution system (7)；The experimental group exposure chamber (63) includes more piece and tests exposure chamber；More concentration dilutions
System (7) includes the second aerosol of the second aerosol diluter (73) and control being arranged between each section experiment exposure chamber
3rd air flow controller (72) of the air inlet amount in diluter (73)；
Second aerosol diluter (73) includes mixing ejector pipe (406), mixing chamber (407) and the second matter inlet
(403)；The first end of the mixing ejector pipe (406) for the first matter inlet (401), first matter inlet (401) with
The experiment exposure chamber in upstream side connects in two adjacent experiment exposure chambers；The mixing ejector pipe (406)
Second end be connected with the mixing chamber (407)；Second matter inlet (403) is to be arranged on the mixing ejector pipe
(406) the gap on tube wall, the gap are formed by the first face being mutually parallel and the second face, first face be with it is described
Mix ejector pipe (406) coaxial circular conical surface, and the gap on the flow direction of the second substance towards the mixing chamber (407)
Direction tilt, and second matter inlet (403) is connected with the 3rd air flow controller (72)；The mixing chamber
(407) cylindrical chamber and second end of the first end cone-shaped cavity being connected with the mixing ejector pipe (406), interlude are included
Cone-shaped cavity, the end of second end cone-shaped cavity offer compounding substances outlet (408), the compounding substances outlet
(408) the experiment exposure chamber in downstream side connects in the experiment exposure chamber adjacent with two.
2. more concentration animal mouth and nose sucking dynamic exposure devices according to claim 1, which is characterized in that the exhaust gas returns
Receive processing system (9) include be sequentially connected waste gas recovery case (91), device for drying and filtering (92), exhaust gas flow controller (93),
Manual ball valve (94), vacuum pump and high altitude discharge processing system (96)；The waste gas recovery case (91) and the waste gas outlet phase
Connection.
3. more concentration animal mouth and nose sucking dynamic exposure devices according to claim 1, which is characterized in that the mouth and nose are sudden and violent
Dew unit (6) further includes oxygen concentration sensor, pressure sensor, temperature sensor and humidity sensor and sampling of aerosol
Pipe, the oxygen concentration sensor, the pressure sensor, the temperature sensor, the humidity sensor and the gas are molten
Glue sampling pipe is arranged in each section experiment exposure chamber.
4. more concentration animal mouth and nose sucking dynamic exposure devices according to claim 1, which is characterized in that further include safety
Shielding cabinet (8) and vacuum tiny structure processing system (5)；
The security mask cabinet (8) includes animal behavior remote monitoring camera (81), headlamp (82), ultraviolet disinfection lamp
(83), USB communication interfaces (84) and for gathering the thief hatch of aerosol sample (85)；
The vacuum tiny structure processing system (5) is used to prevent the aerosol of a small amount of leakage in the security mask cabinet from entering
Air, the vacuum tiny structure processing system (5) include check valve (51), differential pressure indicator (52) and vacuum pump.
5. more concentration animal mouth and nose sucking dynamic exposure device according to any one of claim 1-4, which is characterized in that
Further include sampling system (3) and control system (2).
6. more concentration animal mouth and nose sucking dynamic exposure devices according to claim 5, which is characterized in that the sampling system
System (3) includes being sequentially connected the two-position two-way solenoid valve (31) connect, aerosol concentration monitor (32) and aerosol flow control
Device (35) and vacuum pump；The two-position two-way solenoid valve (31) is connected with the sampling of aerosol pipe.
7. more concentration animal mouth and nose sucking dynamic exposure devices according to claim 5, which is characterized in that the control system
System (2) includes industrial PC (21), touch screen computer (22), software programming control terminal (23), data collecting card (24), relay
Control panel (25), contactor (26) and RS485 communication interfaces (27)；
The contactor (26), the relay control panel (25), the data collecting card (24) and the industrial PC (21)
It is sequentially connected,
The RS485 communication interfaces (27) connect the industrial PC (21), and the software programming control terminal (23) connects institute
Industrial PC (21) is stated, the touch screen computer (22) connects the industrial PC (21).
8. more concentration animal mouth and nose sucking dynamic exposure device according to any one of claim 1-4, which is characterized in that
The mouth and nose exposure unit (6) further includes control group exposure chamber (61).
9. more concentration animal mouth and nose sucking dynamic exposure devices according to claim 1, which is characterized in that the more piece is real
It tests exposure chamber and tests exposure chamber or four section experiment exposure chambers or five section experiment exposure chambers for three sections.
10. more concentration animal mouth and nose sucking dynamic exposure devices according to claim 1, which is characterized in that in the gas
Second aerosol diluter (73) is set at colloidal sol import (112).
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310351055.2A CN104374928B (en) | 2013-08-13 | 2013-08-13 | More concentration animal mouth and nose suck dynamic exposure device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310351055.2A CN104374928B (en) | 2013-08-13 | 2013-08-13 | More concentration animal mouth and nose suck dynamic exposure device |
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| Publication Number | Publication Date |
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| CN104374928A CN104374928A (en) | 2015-02-25 |
| CN104374928B true CN104374928B (en) | 2018-06-01 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014051504A1 (en) * | 2012-09-25 | 2014-04-03 | Inhalation Sciences Sweden Ab | Exposure system for aerosol and model material interaction |
| CN105136619B (en) * | 2015-07-29 | 2018-01-26 | 长三角环境气象预报预警中心（上海市环境气象中心） | A kind of artificial climate environmental exposure system and application process |
| CN105651944B (en) * | 2016-02-25 | 2017-12-08 | 青岛众瑞智能仪器有限公司 | A kind of animal aerosol exposes experimental system |
| CN106175975B (en) * | 2016-07-11 | 2017-07-04 | 中国环境科学研究院 | A kind of oral nasal inhalation contamination device of Powder aerosol dynamic formula |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5297502A (en) * | 1993-05-05 | 1994-03-29 | Jaeger Rudolf J | Modular reversible-flow-past nasopulmonary respiratory dosing system for laboratory animals |
| US7377276B2 (en) * | 2001-01-31 | 2008-05-27 | United States Of America As Represented By The Secretary Of The Army | Automated inhalation toxicology exposure system and method |
| CN101803962B (en) * | 2010-04-23 | 2011-10-05 | 中国人民解放军军事医学科学院微生物流行病研究所 | Rodent oronasal suction dynamic exposing device |
| CN102389339A (en) * | 2011-07-06 | 2012-03-28 | 天津开发区合普工贸有限公司 | Only-nose inhaling poison exposure experimental equipment for rodent |
| CN203029422U (en) * | 2012-12-20 | 2013-07-03 | 中国人民解放军第三军医大学 | Infection concentration tank and rat mouth-nose infection concentration tank |
| CN203432981U (en) * | 2013-08-13 | 2014-02-12 | 北京慧荣和科技有限公司 | Multi-concentration animal oral-nasal inhalation dynamic exposure equipment |
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