CN201788111U - All-in-one machine for fast slide-making and staining of liquid-based thinlayer cells and cell DNAs - Google Patents
All-in-one machine for fast slide-making and staining of liquid-based thinlayer cells and cell DNAs Download PDFInfo
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- CN201788111U CN201788111U CN201020542942XU CN201020542942U CN201788111U CN 201788111 U CN201788111 U CN 201788111U CN 201020542942X U CN201020542942X U CN 201020542942XU CN 201020542942 U CN201020542942 U CN 201020542942U CN 201788111 U CN201788111 U CN 201788111U
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Abstract
An all-in-one machine for fast slide-making and staining of liquid-based thinlayer cells and cell DNAs. The all-in-one machine is disposed in a box body; a slide rack stand is disposed on two rotating disks; a slide rack is fixed in the slide rack stand through a notch structure; a liquid storing bottle and a DNA titration location are arranged on the slide rack; and two extracting disks are arranged above two rotating disks. The utility model could finish specimen treatment, slide-making and staining on the same instrument at one time; the produced specimen slide has stable quality and includes integral cells which are distributed uniformly; the machine could realize fast slide-making and staining at the same time and on the same instrument for liquid-based thinlayer cells and cell DNAs of samples and provide a powerful substance guarantee for timely and accurate conclusion of TBS analysis report of liquid-based cells and quantitative ploid analysis report of cell DNAs. The utility model could treat a large batch of samples in a high efficiency and is especially suitable for large-scale cancer-prevention general-survey and clinic diagnosis and screening in a large speciality hospital.
Description
Technical field
The utility model relates to the device of a kind of liquid based thin-layer cell and cell DNA film-making and dyeing, particularly a kind of LCT liquid based thin-layer cell and the quick film-making of cell DNA and dyeing all-in-one.
Technical background
In the detection method of the examination of human body exfoliative cytology anti-cancer, early diagnosis, cervical exfoliated cell is learned the method that detects examination early cervical carcinoma and precancerous lesion and is shown important especially.Its method of operating is: draw materials to put into Uterine neck bush and preserve the liquid bottle, after last machine is made cell suspension with sample, be divided into two groups, carry out liquid basal cell film-making and dyeing and film-making of cell DNA thin layer and dyeing respectively.In addition, pathological section or frozen section also can directly be gone up machine and carry out cell DNA dyeing.After dying lustful cell patch mounting, carrying out readding chip system by area of computer aided respectively (comprising: TBS report analysis system, cell DNA times body quantified system analysis, cell DNA content in the pathological image analytic system and times body analysis) scan and read sheet, make liquid basal cell TBS analysis report, quantitative times of body analysis report of cell DNA, cell DNA content in the pathological image analytic system and times body analysis report, it is one of important method of judging at present CIN (going up the intracutaneous pathology) state of development, wherein, the DNA heteroploid is a biomarker in the tumour cell forming process, the enforcement of the method can replenish the deficiency of conventional cytology or pathological diagnosis method, can help the judgement of pathologist to tumour character greatly, make it according to above analysis, make the early diagnosis report of early stage (uterine neck) cancer and precancerous lesion examination respectively.
From as can be seen above, the film-making of sample and dyeing quality are the deciding factors that influences liquid basal cell TBS analysis report and quantitative times of body analysis report of cell DNA.
For improving the film-making and the dyeing quality of sample, various liquid basal cell film-making overflow dyeing machines have been developed at present in succession, as the super cypress LCT liquid base pelleter of the U.S., Chinese patent 200920051732.8 also discloses natural subsidence liquid basal cell film-making overflow dyeing machine, it comprises that sampling mechanism, sample hold mechanism, and slide holds seat, dyeing liquor injecting mechanism, the pin that dyes moves up and down structure, lower shoe and control circuit.Adopt this machine can realize that sample disposal, film-making, dyeing once finishes at an instrument.Have advantages such as slice-making quality is stable, efficient is high, cell is complete, be evenly distributed.
But for cell DNA film-making and dyeing, at present still to make by hand; Not only efficient is low, and slice-making quality also is difficult to stablize.The hysteresis of cell DNA film-making and dyeing causes the hysteresis of quantitative times of body analysis report of cell DNA.
The utility model content
For overcoming above-mentioned deficiency, the utility model provides a kind of LCT liquid based thin-layer cell and quick film-making of cell DNA and dyeing all-in-one.
The technical solution of the utility model is: described film-making places in the casing 1 with the dyeing all-in-one; Slide frame deck 3 is evenly arranged on two rotating disks 2; Slide frame deck 3 is provided with draw-in groove, and slide frame 4 is fixed in the slide frame deck 3 by the draw-in groove structure level; Slide frame 4 is provided with protects liquid bottle bearing 7 and DNA titration position 6; Preserving liquid bottle 8 is fixed on guarantor's liquid bottle bearing 7 by helicitic texture, preserving liquid bottle 8 is isolated into preservation liquid bottle charge space 9 and protects liquid bottle through hole space 10, preserve liquid bottle charge space 9 lower end closed, upper end open, preserving liquid bottle through hole space 10 is the through-hole structure of upper and lower opening; Be provided with two suction dishes 11 above two rotating disks 2, suction dish 11 is provided with and slide frame deck 3 corresponding grooves 13, and suction pipe seat 12 places in the groove 13, and A suction pipe, two suction pipes of B suction pipe are installed on each suction pipe seat 12.
The home position of suction dish 11 is equipped with motor, and an end of each suction pipe seat 12 is fixed on groove 13 outer ends with spring, and another very useful draught line is fixed on the motor output shaft; Under the normality, 10 positions, liquid bottle through hole space are protected in the position of the A suction pipe on the same suction pipe seat 12 corresponding, 6 positions, DNA titration position on the corresponding same slide frame 4 of B suction pipe.
All A suction pipes come together in house steward A on the suction dish 11, and all B suction pipes combine in house steward B; House steward A links to each other with damping fluid injection control apparatus, imbibition control device, haematoxylin injection control apparatus, distilled water injection control apparatus, EA/OG injection control apparatus, absolute ethyl alcohol injection control apparatus, dimethylbenzene injection control apparatus respectively, and house steward B links to each other with formalin injection control device, imbibition control device, hydrochloric acid injection control apparatus, distilled water injection control apparatus, Schiff ' s reagent injection control apparatus, ethanol injection control device, absolute ethyl alcohol dehydration injection control apparatus, dimethylbenzene injection control apparatus respectively.
Be emitting shape on each rotating disk 2 and evenly be furnished with 16 slide frame decks 3.
Rotating disk 2 is connected with drive motor by gearing.
Be provided with thermostatically-controlled equipment in the casing.
On the A suction pipe paddle is housed.
The soft sufficient film-making frame of plastics that the leakage of preventing is arranged on the slide frame base plate 5.
The beneficial effects of the utility model are, the utility model can realize that sample disposal, film-making, dyeing once finishes at an instrument.Made sample tablet quality is stable, cell is complete, be evenly distributed.And can realize sample LCT liquid based thin-layer cell and cell DNA simultaneously with quick film-making of machine and dyeing, for liquid basal cell TBS analysis report and quantitative times of body analysis report of cell DNA are made the material guarantee that provides strong in time, accurately.The utility model processing sample is big in batches, efficient is high, especially is fit to the clinical diagnosis and the examination of extensive give protection against cancer generaI investigation and large-scale section hospital.
Below in conjunction with drawings and Examples the utility model is done and to be described in further detail.
Description of drawings
Fig. 1 is the vertical view behind the utility model removal suction dish;
Fig. 2 is the utility model slide frame schematic perspective view;
Fig. 3 preserves liquid bottle front view for the utility model;
Fig. 4 is the utility model suction dish upward view.
Among the figure: 1. casing, 2. rotating disk, 3. slide frame deck, 4. slide frame, 5. slide frame base plate, liquid bottle bearing is 7. protected in 6.DNA titration position, 8. preserves the liquid bottle, 9. preserves liquid bottle charge space, 10. preserves liquid bottle through hole space, 11. suction dishes, 12. suction pipe seats, 13. grooves.
Embodiment
The sampling pre-service: after the Uterine neck bush sampling, the Uterine neck bush of collecting cell is preserved in the preservation liquid bottle charge space 9, adds an amount of 0.1%DTT (dithiothreitol (DTT)) digestive juice 1.5ml, it is stand-by then it to be sticked the name number label.To be collected behind the sample of some, with above-mentioned preservation have guarantor's liquid bottle 8 usefulness shakers of Uterine neck bush vibrate 30-60min (150 times/min).
Last machine is fixed: clean slide and the soft sufficient frame of plastics are placed on the slide frame base plate 5, take out the Uterine neck bush of preserving in the liquid bottle 8, will preserve liquid bottle 8 and be fixed in regular turn in guarantor's liquid bottle bearing 7, slide frame 4 is fixed in the slide frame deck 3 by the draw-in groove structure again.When sample was discontented with 32, sample slide frame 4 symmetries were placed.
Centrifugal: rotating disk 2 is finished preserving the centrifugally operated of sample in the liquid bottle charge space 9 with the speed rotation 5min of 800r/min.
Abandon supernatant: drive rotating disk to desired location, all A suction pipes are preserved in 9 liquid of liquid bottle charge space over against one separately, and suction dish 11 moves downward, all A suction pipes be inserted into separately over against preservation liquid bottle charge space 9 in.The imbibition control device that driving links to each other with house steward A, the imbibition control device produces negative pressure, and the supernatant that the A suction pipe is drawn all samples drains into waste liquid pool, and suction dish 11 moves upward, and finishes the supernatant of abandoning of all samples is operated.
Add ethanol: drive the ethanol injection control device link to each other with house steward A, the A suction pipe to separately over against preservation liquid bottle charge space 9 in inject 50% ethanol 2ml, suction dish 11 moves upward, and finishes the ethanol operation that adds to all samples.
Repeat the above-mentioned centrifugation step of secondary, repeat the above-mentioned supernatant step of abandoning of secondary again.
Add immobile liquid: drive the formalin injection control device link to each other with house steward A, the A suction pipe to separately over against preservation liquid bottle charge space 9 in injection 4% formalin buffer 2ml, suction dish 11 moves upward, and finishes the immobile liquid that adds of all samples is operated.
Stirring and evenly mixing: suction dish 11 moves downward, all A suction pipes be inserted into separately over against preservation liquid bottle charge space 9 in, it is an amount of to inject the cell damping fluid.Computerized control system with the CO8000 principle under 600nm light or the little cell density of measuring cell suspension of Lamb ripple, cell density is divided into density is little, density is big, the moderate Three Estate of density, the little grade of density added cell damping fluid 0.7ml, the density middle grade add cell damping fluid 1.0ml, the big grade of density add cell buffering 1.5ml, make the cell density of each sample tube roughly the same, guarantee the quality height of made cell patch.Stir cell suspension 2S immediately, the driving suction is coiled 11 quick little displacements and is back and forth rotated, owing to have paddle on the A suction pipe, even the little displacement movement of A suction pipe, also can reach the effect of liquid in the abundant blender jar, suction dish 11 moves upward, and finishes the stirring and evenly mixing operation to all samples.Promptly make cell suspension.
Annotate cell suspension: suction dish 11 moves downward, all A suction pipes be inserted into separately over against preservation liquid bottle charge space 9 in.The imbibition control device that driving links to each other with house steward A, the imbibition control device produces negative pressure, and the A suction pipe adsorbs cell suspension under suction function, and suction dish 11 moves upward, and the A suction pipe leaves preserves liquid bottle charge space 9.At this moment, drive suction and coil the motor of 11 home positions, draught line spurs each suction pipe seat 12 and coils 11 home positions to suction and move, make the A suction pipe over against preserving 10 positions, liquid bottle through hole space, the imbibition control device that driving links to each other with house steward A, discharge negative pressure, the A suction pipe is annotated cell suspension 0.5ml to preserving liquid bottle through hole space 10.Drive suction again and coil the motor of 11 home positions, draught line spurs each suction pipe seat 12 to be continued to coil 11 home positions to suction and moves, and makes the A suction pipe over against DNA titration position 6, drives the imbibition control device that links to each other with house steward A, discharge negative pressure, the A suction pipe is annotated cell suspension 0.5ml to DNA titration position 6.Drive the motor backward rotation that 11 home positions are coiled in suction, discharge draught line, make all each suction pipe seats 12 reply the normality position, finish notes cell suspension operation all samples.
Cell suspension is in 6 positions, DNA titration position and preserve natural sedimentation 10min under the 10 position horizontalitys of liquid bottle through hole space, forward and backward rotation rotating disk are 3 times again, cell overlapping on the cell patch is shaken fall on the bottom diaphragm to be evenly distributed, promptly make the cell monolayer diaphragm.
Feulgen dyeing: open thermostatically-controlled equipment and make 37 ℃ of the interior maintenances of casing, hydrochloric acid and Schiffs reagent keep 60 ℃.
1. annotate formalin: drive the formalin injection control device that links to each other with house steward B, the B suction pipe injects 10% formalin buffer 1ml to DNA titration position;
2. removal waste fluid: suction dish 11 moves downward, all B suction pipes be inserted into separately over against DNA titration position, the imbibition control device that driving links to each other with house steward B, imbibition control device produce negative pressure, and the B suction pipe has adsorbed the surplus annex solution under suction function and enters waste liquid pool;
3. annotate hydrochloric acid: drive the hydrochloric acid injection control apparatus that links to each other with house steward B, the B suction pipe injects 5mol/L hydrochloric acid 1ml hydrolysis 5min to DNA titration position; 2. removal waste fluid is once for repeating step;
4. rinsing: drive the distilled water injection control apparatus that links to each other with house steward B, the B suction pipe injects distilled water 2ml to DNA titration position and carries out rinsing 10S; 2. removal waste fluid is once for repeating step;
Repeating step 4. once;
5. dyeing: drive the Schiff ' s reagent injection control apparatus that links to each other with house steward B, the B suction pipe injects Schiff ' s reagent 2ml, dyeing 10min to DNA titration position; 2. removal waste fluid is once for repeating step;
Repeating step 4. once;
6. ethanol dehydration: drive the ethanol injection control device link to each other with house steward B, the B suction pipe injects the 95% ethanol 2ml 10S that dewaters to DNA titration position;
7. absolute ethyl alcohol dehydration: drive the absolute ethyl alcohol injection control apparatus that links to each other with house steward B, the B suction pipe injects the absolute ethyl alcohol 2ml 10S that dewaters to DNA titration position;
8. annotate dimethylbenzene: drive the dimethylbenzene injection control apparatus link to each other with house steward B, the B suction pipe to separately over against DNA titration position inject dimethylbenzene 1ml, keep 5S;
Above-mentioned at every turn adding, carried out a 2. removal waste fluid action of step simultaneously after the reagent program is finished, promptly make the Feulgen staining section of cell DNA.
Pap staining:
1. A suction pipe contraposition: drive the motor that 11 home positions are coiled in suction, place groove inner suction pipe seat 12 under the draught line pulling, coil 11 home positions along groove to suction and move, make the A suction pipe over against preserving 10 positions, liquid bottle through hole space;
2. annotate damping fluid: drive the damping fluid injection control apparatus link to each other with house steward A, the A suction pipe to separately over against preservation liquid bottle through hole space 10 inject damping fluid 1ml, buffering 30S;
3. removal waste fluid: suction dish 11 moves downward, all A suction pipes be inserted into separately over against preservation liquid bottle through hole space 10, the imbibition control device that driving links to each other with house steward A, imbibition control device produce negative pressure, and the A suction pipe has adsorbed the surplus annex solution under suction function and enters waste liquid pool;
4. annotate haematoxylin: drive the haematoxylin injection control apparatus link to each other with house steward A, the A suction pipe to separately over against preservation liquid bottle through hole space 10 inject haematoxylin 1ml, keep 90S;
2. repeating step annotates damping fluid 2 times, each 10S;
5. flushing: drive the distilled water injection control apparatus link to each other with house steward A, the A suction pipe to separately over against guarantor's liquid bottle through hole space 10 inject distilled water 2ml, flushing 10S;
5. repeating step washes 1 time;
6. annotate EA/OG: drive the EA/OG injection control apparatus link to each other with house steward A, the A suction pipe to separately over against preservation liquid bottle through hole space 10 inject EA/OG1ml, keep 90S;
2. repeating step annotates damping fluid 2 times;
7. absolute ethyl alcohol dehydration: drive the absolute ethyl alcohol injection control apparatus that links to each other with house steward A, the A suction pipe to separately over against preservation liquid bottle through hole space 10 inject the absolute ethyl alcohol 2ml 10S that dewaters;
8. annotate dimethylbenzene: drive the dimethylbenzene injection control apparatus link to each other with house steward A, the A suction pipe to separately over against preservation liquid bottle through hole space 10 inject dimethylbenzene 1ml, keep 5S;
9. suction pipe seat resets: drive the motor backward rotation that 11 home positions are coiled in suction, discharge draught line, all suction pipe seats 12 are replied the normality position;
Above-mentioned at every turn adding, promptly carried out a 3. removal waste fluid action of step after the reagent program is finished, promptly make liquid basal cell pap staining sheet.
Take out slide, post the name number label, add neutral gum and cover glass respectively in cell DNA film position and liquid basal cell film position, with liquid basal cell staining section and the cell DNA staining section that makes, scan by area of computer aided cell detecting system and quantitative times of body analytic system of full-automatic cell DNA respectively and read sheet, can make quantitative times of body analysis report of liquid basal cell TBS analysis report and cell DNA simultaneously.
Above-mentioned making flow process is all controlled automatically by computerized control system.Each rotating disk of the utility model is provided with 16 slide frame cards, and each suction dish is provided with 16 corresponding suction pipe seats, once can handle 32 samples.
Except that being applied in specimen preparation such as uterine neck, ascites pleural fluid, sputum, urine, cerebrospinal fluid, puncture fluid and dyeing, the utility model can also be reported the result with quantitative times of body analytic system of the cell DNA in the pathological image analytic system to doing cell Feulgen dyeing through paraffin or freezing pathological section.
Claims (9)
1. LCT liquid based thin-layer cell and the quick film-making of cell DNA and dyeing all-in-one is characterized in that: described film-making places in the casing (1) with the dyeing all-in-one; Slide frame deck (3) is evenly arranged on two rotating disks (2); Slide frame deck (3) is provided with draw-in groove, and slide frame (4) is fixed in the slide frame deck (3) by the draw-in groove structure level; Slide frame (4) is provided with protects liquid bottle bearing (7) and DNA titration position (6); Preserving liquid bottle (8) is fixed on guarantor's liquid bottle bearing (7) by helicitic texture, preserving liquid bottle (8) is isolated into preservation liquid bottle charge space (9) and protects liquid bottle through hole space (10), preserve liquid bottle charge space (9) lower end closed, upper end open, preserving liquid bottle through hole space (10) is the through-hole structure of upper and lower opening; Be provided with two suction dishes (11) in the top of two rotating disks (2), suction dish (11) is provided with and the corresponding groove of slide frame deck (3) (13), suction pipe seat (12) places in the groove (13), and A suction pipe, two suction pipes of B suction pipe are installed on each suction pipe seat (12).
2. LCT liquid based thin-layer cell according to claim 1 and the quick film-making of cell DNA and dyeing all-in-one, it is characterized in that: the home position of suction dish (11) is equipped with motor, one end of each suction pipe seat (12) is fixed on groove (13) outer end with spring, and another very useful draught line is fixed on the motor output shaft; Under the normality, position, liquid bottle through hole space (10) is protected in the position of the A suction pipe on the same suction pipe seat (12) corresponding, the position, DNA titration position (6) on the corresponding same slide frame of B suction pipe (4).
3. LCT liquid based thin-layer cell according to claim 1 and the quick film-making of cell DNA and dyeing all-in-one, it is characterized in that: suction dish (11) is gone up all A suction pipes and is come together in house steward A, and all B suction pipes combine in house steward B; House steward A links to each other with damping fluid injection control apparatus, imbibition control device, haematoxylin injection control apparatus, distilled water injection control apparatus, EA/OG injection control apparatus, absolute ethyl alcohol injection control apparatus, dimethylbenzene injection control apparatus respectively, and house steward B links to each other with formalin injection control device, imbibition control device, hydrochloric acid injection control apparatus, distilled water injection control apparatus, Schiff ' s reagent injection control apparatus, ethanol injection control device, absolute ethyl alcohol dehydration injection control apparatus, dimethylbenzene injection control apparatus respectively.
4. LCT liquid based thin-layer cell according to claim 1 and the quick film-making of cell DNA and dyeing all-in-one is characterized in that: be emitting shape on each rotating disk (2) and evenly be furnished with 16 slide frame decks (3).
5. LCT liquid based thin-layer cell according to claim 1 and the quick film-making of cell DNA and dyeing all-in-one, it is characterized in that: rotating disk (2) is connected with drive motor by gearing.
6. LCT liquid based thin-layer cell according to claim 1 and the quick film-making of cell DNA and dyeing all-in-one is characterized in that: be provided with thermostatically-controlled equipment in the casing.
7. LCT liquid based thin-layer cell according to claim 1 and the quick film-making of cell DNA and dyeing all-in-one is characterized in that: on the A suction pipe paddle is housed.
8. LCT liquid based thin-layer cell according to claim 1 and the quick film-making of cell DNA and dyeing all-in-one, it is characterized in that: suction dish (11) is installed on the elevating mechanism at casing top.
9. LCT liquid based thin-layer cell according to claim 1 and the quick film-making of cell DNA and dyeing all-in-one is characterized in that: the soft sufficient film-making frame of plastics that the leakage of preventing is arranged on the slide frame base plate (5).
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201020542942XU CN201788111U (en) | 2010-09-19 | 2010-09-19 | All-in-one machine for fast slide-making and staining of liquid-based thinlayer cells and cell DNAs |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201020542942XU CN201788111U (en) | 2010-09-19 | 2010-09-19 | All-in-one machine for fast slide-making and staining of liquid-based thinlayer cells and cell DNAs |
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| CN201788111U true CN201788111U (en) | 2011-04-06 |
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| CN201020542942XU Expired - Fee Related CN201788111U (en) | 2010-09-19 | 2010-09-19 | All-in-one machine for fast slide-making and staining of liquid-based thinlayer cells and cell DNAs |
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Cited By (8)
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| CN103207106A (en) * | 2013-04-24 | 2013-07-17 | 梁建中 | Turntable type frozen slice dyeing machine |
| CN103543058A (en) * | 2012-07-10 | 2014-01-29 | 天津百利鑫生物科技有限公司 | Liquid injection and suction method for cell slide-making dyeing machine and device thereof |
| CN104614332A (en) * | 2015-02-02 | 2015-05-13 | 武汉呵尔医疗科技发展有限公司 | Quantitative measurement method of cell DNA under redyeing environment |
| CN104677824A (en) * | 2015-03-03 | 2015-06-03 | 张莉 | Tumor pathological nuclear morphological parameter measuring device |
| CN105675374A (en) * | 2016-03-10 | 2016-06-15 | 刘崇梅 | Semi-automatic smearing method of hydrothorax and ascite liquid-base cytology |
| CN108918222A (en) * | 2018-07-12 | 2018-11-30 | 上海裕隆医学检验所股份有限公司 | The cell collection device of diaphragm type liquid foot cell pellet mill |
| CN109520805A (en) * | 2018-11-27 | 2019-03-26 | 武汉医尔特科技有限公司 | A kind of full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine |
| WO2022073335A1 (en) * | 2020-10-09 | 2022-04-14 | 嘉兴晶铸生物科技有限公司 | Fully automated method for production of exfoliated cells |
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2010
- 2010-09-19 CN CN201020542942XU patent/CN201788111U/en not_active Expired - Fee Related
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103543058A (en) * | 2012-07-10 | 2014-01-29 | 天津百利鑫生物科技有限公司 | Liquid injection and suction method for cell slide-making dyeing machine and device thereof |
| CN103543058B (en) * | 2012-07-10 | 2016-06-15 | 天津百利鑫生物科技有限公司 | For fluid injection imbibition method and the device thereof of cell preparation staining machine |
| CN103207106A (en) * | 2013-04-24 | 2013-07-17 | 梁建中 | Turntable type frozen slice dyeing machine |
| CN104614332A (en) * | 2015-02-02 | 2015-05-13 | 武汉呵尔医疗科技发展有限公司 | Quantitative measurement method of cell DNA under redyeing environment |
| CN104614332B (en) * | 2015-02-02 | 2017-05-10 | 武汉呵尔医疗科技发展有限公司 | Quantitative measurement method of cell DNA under redyeing environment |
| CN104677824A (en) * | 2015-03-03 | 2015-06-03 | 张莉 | Tumor pathological nuclear morphological parameter measuring device |
| CN105675374A (en) * | 2016-03-10 | 2016-06-15 | 刘崇梅 | Semi-automatic smearing method of hydrothorax and ascite liquid-base cytology |
| CN108918222A (en) * | 2018-07-12 | 2018-11-30 | 上海裕隆医学检验所股份有限公司 | The cell collection device of diaphragm type liquid foot cell pellet mill |
| CN109520805A (en) * | 2018-11-27 | 2019-03-26 | 武汉医尔特科技有限公司 | A kind of full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine |
| WO2022073335A1 (en) * | 2020-10-09 | 2022-04-14 | 嘉兴晶铸生物科技有限公司 | Fully automated method for production of exfoliated cells |
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Legal Events
| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110406 Termination date: 20110919 |