CN201346410Y - Continuous middle-pressure post tomographic separation facility - Google Patents

Continuous middle-pressure post tomographic separation facility Download PDF

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Publication number
CN201346410Y
CN201346410Y CNU2008202383963U CN200820238396U CN201346410Y CN 201346410 Y CN201346410 Y CN 201346410Y CN U2008202383963 U CNU2008202383963 U CN U2008202383963U CN 200820238396 U CN200820238396 U CN 200820238396U CN 201346410 Y CN201346410 Y CN 201346410Y
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CN
China
Prior art keywords
feed arrangement
feeding device
cylinder
column chromatography
medium pressure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNU2008202383963U
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Chinese (zh)
Inventor
刘玲
顾正桂
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Nanjing Normal University
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Nanjing Normal University
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Priority to CNU2008202383963U priority Critical patent/CN201346410Y/en
Application granted granted Critical
Publication of CN201346410Y publication Critical patent/CN201346410Y/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Abstract

A continuous middle-pressure post tomographic separation facility comprises a feeding device, a post part and a discharging device which are connected from the top down, and is characterized in that the feeding device is provided with a post head pressurization mechanism, and the structure of the post head pressurization mechanism is that the feeding device is provided with a pressurization port, and an inactive gas steel cylinder (such as a nitrogen cylinder) is connected with the feeding device through a manometer and the pressurization port. In the optimized scheme, the feed inlet on the top end of the feeding device adopts the external screw thread port design. The right side on the lower end of the feeding device is opened with a discharge port which is controlled by a cork. The continuous middle-pressure post tomographic separation facility has the advantages of fast and simple operation, low power consumption, effectively separating mixture, no pollution in experiment processes and the like. The nitrogen cylinder can be easily pressurized and controlled, is stable, and has no pollution in experiment processes, the post and the feeding device can be easily disassembled, which is convenient for cleaning, granule-thin adsorbent can be selected, mixture which is difficult to separate can be separated, and the whole facility has excellent sealing performance and stable system after pressurization.

Description

Continuous medium pressure column chromatography separator
Technical field
The utility model relates to the separator of a kind of biology, chemical field, is specifically related to a kind of continuous medium pressure column chromatography separator, is a kind of a kind of novel medium pressure column chromatography device that is applicable to separating natural plant, Chinese medicine, active ingredient monomer.
Background technology
At present, the separation of chemical product or natural products mainly is to utilize normal pressure and decompression chromatographic column.Normal pressure chromatographic column, eluant, eluent rely on gravity that each component in the mixture is eluted successively, because the internal pressure deficiency can only be used the bigger adsorbent of particle, and the wash-out consumed time is long and final effect is relatively poor.The decompression chromatographic column is the pressure that utilizes water pump to bleed to reduce in the filter flask, and washing and dehydrating integrated machine relies on external atmosphere pressure that each component in the mixture is eluted successively, and the solvent loss that its uses is many, operates comparatively loaded down with trivial detailsly, and separating effect is also undesirable.
Summary of the invention
At the above-mentioned deficiency of prior art, the purpose of the utility model device provides a kind of continuous medium pressure column chromatography separator, the continuous medium pressure column chromatography separator that this device can quick, easy and simple to handle, effective each component of separating mixture.
The technical scheme that the utility model provides is: a kind of continuous medium pressure column chromatography separator, connect and compose by top-down feed arrangement, cylinder part and drawing mechanism, it is characterized in that, on feed arrangement, be provided with the column cap pressing mechanism, the structure of this column cap pressing mechanism is: be provided with the pressurization mouth on feed arrangement, inert gas steel cylinder (for example, nitrogen cylinder) links to each other with feed arrangement with this pressurization mouth by Pressure gauge.
Package unit of the present utility model adopts glass to make, and mainly is made up of four parts: column cap pressures partially, feed arrangement, cylinder part and drawing mechanism.Column cap pressurization is to exert pressure by nitrogen cylinder, and feed arrangement roughly is funnel-form, and the top is provided with charging aperture and pressurization mouthful, and the lower end, right side is provided with the side line discharging opening, adopts flange to be connected between feed arrangement and the cylinder, is evenly distributed with four bolts hole on every side.Also adopt identical connection between cylinder and the drawing mechanism.The centre of drawing mechanism is covered with one deck quartz sand.
During use, column body is filled with fixedly phase, flow to be added to feed arrangement and to feed continuously in the chromatographic column, and last sample, logical nitrogen pressure, separated component is according to separating with mobile mutually interactional different reaching effectively with fixing phase separately.
In other words, the concrete structure of above-described continuous medium pressure column chromatography separator is: the column cap pressures partially is to adopt the pressurization of nitrogen steel cylinder, and is simple to operate, is convenient to control.Feed arrangement is funnel type, and the top is provided with charging aperture and pressurization mouth, and charging aperture adopts the design of external screw thread mouth, can guarantee the sealing of compression system like this.The lower end, right side of feed arrangement is provided with the side line discharging opening, and outlet is controlled by cock, adds when excessive as eluant, eluent, then can emit from the side, does like this and has saved solvent.Adopt flange to be connected between feed arrangement and the cylinder, the centre is provided with pad, and four bolts hole that evenly distribute on every side adopt not only convenient disassembly of such connection, be convenient to cleaning, and the sealing of system is guaranteed.Also adopted identical connection between cylinder and the drawing mechanism.The centre of drawing mechanism is covered with one deck quartz sand, is carrying the fixedly phase that column interior is filled, and prevents that whole pillar is contaminated.
Beneficial effect: this continuous medium pressure column chromatography separator has quick, easy and simple to handle, advantages such as energy resource consumption is low, effective separating mixture, experimentation is pollution-free, be embodied in: 1. continuous medium pressure column chromatography, speed is fast, and the conventional efficient height is fit to suitability for industrialized production; 2. adopt the nitrogen cylinder pressurization, simple to operate, easy to control, device is stable; 3. experimentation is pollution-free, and industrial continuous production is convenient in all recyclable utilization of used mobile phase solvent; 4. between cylinder and the feed arrangement, all adopt flange to be connected between cylinder and the drawing mechanism, convenient disassembly is convenient to clean; 5. owing to adopted pressurization, then can select the thin adsorbent of particle for use, so just can be used to separate the mixture of difficult separation; 6. whole device good airproof performance, pressurization back system stability.
Description of drawings
Fig. 1 is the continuous medium pressure column chromatography separator of a utility model structural representation.
The specific embodiment
Embodiment 1, with reference to Fig. 1: the medium pressure column chromatography separator is by pressure regulation column cap device 1 continuously, feed arrangement 2, and cylinder 3 and drawing mechanism 4 constitute, column cap device 1 comprises nitrogen steel cylinder 1-1 and Pressure gauge 1-2, and the column cap device links to each other with feed arrangement 2 by a pressurization mouthful 2-1.Feed arrangement 2 tops have charging aperture 2-2, are designed to the external screw thread mouth, and the lower end, right side has side line discharging opening 2-3.Be connected by flange 5 between feed arrangement 2 and the cylinder 3, flange 5 comprises pad 5-1 and equally distributed four bolt hole 5-2.Be connected by flange 6 between cylinder 3 and the drawing mechanism 4, concrete structure is identical with flange 5.Be covered with one deck quartz sand 4-1 in the middle of the drawing mechanism 4, the lower end discharging opening is controlled by cock 4-2.When eluant, eluent is excessive, be convenient to emit from the side, saved solvent.
Because whole device is a compression resistance, in order to keep the stability of system, the glass wall thickening of cylinder.Thickness is 5cm.
The continuous medium pressure column chromatography separator of the utility model is a kind of device that is applicable to separating natural plant, Chinese medicine, active ingredient monomer.Whole device is made by glass, consider and need bear certain pressure, so the glass wall thickness is 0.5cm.Feed arrangement roughly is funnel-form, and charging aperture 2-2 internal diameter is 2.0cm, the long 10cm in upper end, and lower end 2cm, 45 ° of radians of upper and lower side connect, and the lower end, right side has the side line discharging opening.Cylinder internal diameter 2.5cm, flange diameter 11.5cm, four bolts hole that evenly distribute on every side, the aperture is 1cm.

Claims (6)

1, a kind of continuous medium pressure column chromatography separator, connect and compose by top-down feed arrangement, cylinder part and drawing mechanism, it is characterized in that, on feed arrangement, be provided with the column cap pressing mechanism, the structure of this column cap pressing mechanism is: be provided with the pressurization mouth on feed arrangement, the inert gas steel cylinder links to each other with feed arrangement with this pressurization mouth by Pressure gauge.
2, according to the described continuous medium pressure column chromatography separator of claim 1, it is characterized in that: the charging aperture on described feed arrangement top, adopt the design of external screw thread mouth.
3, according to the described continuous medium pressure column chromatography separator of claim 1, it is characterized in that: the right side of described feed arrangement lower end has discharging opening, and outlet is controlled by cock.
4, according to the described continuous medium pressure column chromatography separator of claim 1, it is characterized in that: adopt flange to connect between described cylinder part and the feed arrangement, the flange circle is four bolts hole of distribution evenly, and the centre is provided with pad, also adopt identical flange to connect between cylinder and the drawing mechanism.
6, according to the described continuous medium pressure column chromatography separator of one of claim 1~5, it is characterized in that: the drawing mechanism of cylinder below, the centre is covered with one deck quartz sand, and the fixedly phase that the carrying column interior is filled prevents that whole pillar is contaminated.
7, according to the described continuous medium pressure column chromatography separator of claim 1, it is characterized in that: the glass wall thickening of cylinder: thickness is 5cm.
CNU2008202383963U 2008-12-30 2008-12-30 Continuous middle-pressure post tomographic separation facility Expired - Fee Related CN201346410Y (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CNU2008202383963U CN201346410Y (en) 2008-12-30 2008-12-30 Continuous middle-pressure post tomographic separation facility

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNU2008202383963U CN201346410Y (en) 2008-12-30 2008-12-30 Continuous middle-pressure post tomographic separation facility

Publications (1)

Publication Number Publication Date
CN201346410Y true CN201346410Y (en) 2009-11-18

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Family Applications (1)

Application Number Title Priority Date Filing Date
CNU2008202383963U Expired - Fee Related CN201346410Y (en) 2008-12-30 2008-12-30 Continuous middle-pressure post tomographic separation facility

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103007578A (en) * 2012-12-10 2013-04-03 福建省微生物研究所 Antibiotic purifying device

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103007578A (en) * 2012-12-10 2013-04-03 福建省微生物研究所 Antibiotic purifying device
CN103007578B (en) * 2012-12-10 2015-07-22 福建省微生物研究所 Antibiotic purifying device

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GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20091118

Termination date: 20121230