CN103007578B - Antibiotic purifying device - Google Patents
Antibiotic purifying device Download PDFInfo
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- CN103007578B CN103007578B CN201210529782.9A CN201210529782A CN103007578B CN 103007578 B CN103007578 B CN 103007578B CN 201210529782 A CN201210529782 A CN 201210529782A CN 103007578 B CN103007578 B CN 103007578B
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- column body
- internal diameter
- lower prop
- recess
- bayonet socket
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Abstract
The invention provides an antibiotic purifying device. The antibiotic purifying device comprises a top cover, an upper column body, a lower column body communicated with the upper column body, and a bottom cover, wherein the top cover and the upper column body, and the lower column body and the bottom cover are connected through locking components respectively; a feeding pipe is communicated with the top cover; the upper column body and the lower column body is connected in a locking way; the upper column body comprises a feeding end and a discharging end; the internal diameter of the feeding end is larger than the internal diameter of the discharging end; the internal diameter of the discharging end is equal to the internal diameter of the lower column body; liner plates are arranged between the upper column body and the lower column body, and between the lower column body and the bottom cover respectively; a plurality of small holes are formed on each liner plate; each liner plate is covered by a cotton layer; the cotton layer is further covered by a filler layer; and a collecting pipe is communicated with the bottom cover. The antibiotic purifying device can separate impurities with large structural difference and homolog with structural similarity at the same time, thus achieving an energy-saving and emission-reducing effect.
Description
[technical field]
The present invention relates to a kind of chromatographic column, particularly relate to a kind of antibiotic purification device.
[background technology]
Traditional tomography devices is the tubular equipment adopting homogeneous diameter, baffle plate and discharge nozzle are set bottom column, top arranges feed pipe, the compound large for some architectural differences adopts short column, and for the homologue compound of similar, often need longer height and diameter proportion to reach separation and purification, and for ferment antibiotics product, often along with dissimilar impurity, there is the impurity that structural property difference is large, also the homologue that structural property is similar is had, in order to effectively be separated these impurity, need to convert different chromatography scheme, cause the factors such as operating procedure is numerous and diverse, production cost can be caused larger to industrial-scale.
[summary of the invention]
Technical problem to be solved by this invention is to provide a kind of antibiotic purification device, can carry out effective magazins' layout and purifying rapidly to product, and applied sample amount increases, and the mixed bed chromatography that simultaneously can carry out unlike material uses.
The present invention solves the problems of the technologies described above by the following technical programs: a kind of antibiotic purification device, comprises a top cover, a column body, the lower prop be connected with described column body and a bottom; Described top cover is connected respectively by a lock cell with between column body, between lower prop and bottom; Described top cover is communicated with a feed pipe; Described column body with lock between lower prop pay be connected, this column body comprises a feed end and a discharge end, and the internal diameter of described feed end is greater than the internal diameter of discharge end, and the internal diameter of described discharge end is equal with the internal diameter of described lower prop; Be respectively equipped with a pad between described column body and lower prop, between lower prop and bottom, every described pad be equipped with a plurality of aperture, and this pad is covered with a cotton layer, described cotton layer is covered with a packing layer; Described bottom is communicated with a collecting pipe.
Preferably, the top of described bottom is equipped with a groove, and the pad between lower prop and bottom is arranged on this groove.
Preferably, described lock cell comprises the first locking mechanism, and this first locking mechanism comprises a plurality of first recess, a plurality of first bayonet socket and a plurality of first locking piece; Described first recess, the first bayonet socket are located at the edge of described top cover and the edge of feed end respectively; Described first locking piece is located at below described feed end, and described first recess, the first bayonet socket, the first locking piece one_to_one corresponding are arranged, and the first locking piece blocks described top cover by described first recess, the first bayonet socket.
Preferably, described lower prop has a discharging opening; Described lock cell also comprises the second locking mechanism, and this second locking mechanism comprises a plurality of second recess, a plurality of second bayonet socket and a plurality of second locking piece; Described second recess, the second bayonet socket are located at the edge of described discharging opening and the lateral edges on bottom top respectively; Described second locking piece is positioned at the top of described discharging opening; Described second recess, the second bayonet socket, the second locking piece one_to_one corresponding are arranged, and the second locking piece blocks described bottom by described second recess, the second bayonet socket.
Preferably, the height of described column body is 4:1 with internal diameter ratio.
Preferably, the height of described lower prop is 15:1 with internal diameter ratio.
Preferably, described top cover is also provided with a bleeder pipe.
Preferably, described bottom is also communicated with a sewer pipe, and this sewer pipe is provided with a switch.
Beneficial effect of the present invention is: can impurity that simultaneously isolating construction nature difference the is large homologue similar with structural property, reaches effect of energy-saving and emission-reduction.
[accompanying drawing explanation]
The invention will be further described in conjunction with the embodiments with reference to the accompanying drawings.
Fig. 1 is the structural representation of a kind of antibiotic purification device of the present invention.
Fig. 2 be in the present invention top cover and column body coordinate figure.
Fig. 3 is the cooperation figure of lower prop and bottom in the present invention.
[detailed description of the invention]
Refer to Fig. 1-3, a kind of antibiotic purification device, comprise lower prop 3 and a bottom 4 that top cover 1, column body 2, is connected with described column body 2; Described top cover 1 is connected respectively by a lock cell 5 with between column body 2, between lower prop 3 and bottom 4.
Referring again to Fig. 1-3, described top cover 1 is communicated with a feed pipe 6, this top cover 1 is also provided with a bleeder pipe 7.Described column body 2 with lock between lower prop 3 pay be connected, this column body 2 comprises feed end 21 and a discharge end 22, and the internal diameter of described feed end 21 is greater than the internal diameter of discharge end 22, and the internal diameter of described discharge end 22 is equal with the internal diameter of described lower prop 3.
Described lock cell 5 comprises the first locking mechanism 51 and the second locking mechanism 52, and this first locking mechanism 51 comprises a plurality of first recess 511, a plurality of first bayonet socket 512 and a plurality of first locking piece 513; Described first recess 511, first bayonet socket 512 is located at the edge of described top cover 1 and the edge of feed end 21 respectively; Described first locking piece 513 is located at below described feed end 21, and described first recess 511, first bayonet socket 512, first locking piece 513 one_to_one corresponding is arranged, and the first locking piece 513 blocks described top cover 1 by described first recess 511, first bayonet socket 512.
Described lower prop 3 has a discharging opening 31; Described second locking mechanism 52 comprises a plurality of second recess 521, a plurality of second bayonet socket 522 and a plurality of second locking piece 523; Described second recess 521, second bayonet socket 522 is located at the edge of described discharging opening 31 and the lateral edges on bottom 4 top respectively; Described second locking piece 523 is positioned at the top of described discharging opening; Described second recess 521, second bayonet socket 522, second locking piece 523 one_to_one corresponding is arranged, and the second locking piece 523 blocks described bottom by described second recess 521, second bayonet socket 522.
The height of described column body 2 is with internal diameter than being 4:1, and the height of described lower prop 3 is 15:1 with internal diameter ratio.A pad 8 is respectively equipped with between described column body 2 and lower prop 3, between lower prop 3 and bottom 4, every described pad 8 is equipped with a plurality of aperture (not shown), and this pad 8 is covered with a cotton layer 9, described cotton layer 9 is also covered with a packing layer (not shown); Described bottom 4 is communicated with a collecting pipe 10, the top of this bottom 4 is equipped with a groove 41, and the pad 8 between lower prop 3 and bottom 4 is arranged on this groove 41; Described bottom 4 is also communicated with a sewer pipe 12, and this sewer pipe 12 is provided with a switch (not shown).
Column body 2 and the packing layer in lower prop 3 of invention can be the chromatographic stuffing layer of different model, column body 2 mainly plays initial gross separation, and most impurity can be separated with target components, lower prop 3 is mainly for separating of homologous components, play isolating construction analog, improve product purity.
Compared with existing purification devices, by the chromatographic stuffing layer of same volume, mutually level chromatographic column calculates, the present invention's solvent used uses about 10%, time shorten 1/6, less under identical applied sample amount condition, sample purity improves, and pure component yield improves about 7 ~ 9% on year-on-year basis.In a word, conventional chromatographic column once cannot use two kinds of fillers simultaneously, and with chromatographic column many losses chromatographic stuffing and the eluting solvent of specific volume, thus the present invention has effect of energy-saving and emission-reduction.
The present invention as tacrolimus, cyclosporin etc. mainly for separating of purifying immunodepressant, is also applicable to other ferment antibiotics purifying and uses.
Claims (8)
1. an antibiotic purification device, is characterized in that: comprise a top cover, a column body, the lower prop be connected with described column body and a bottom; Described top cover is connected respectively by a lock cell with between column body, between lower prop and bottom; Described top cover is communicated with a feed pipe; Described column body with lock between lower prop pay be connected, this column body comprises a feed end and a discharge end, and the internal diameter of described feed end is greater than the internal diameter of discharge end, and the internal diameter of described discharge end is equal with the internal diameter of described lower prop; Be respectively equipped with a pad between described column body and lower prop, between lower prop and bottom, every described pad be equipped with a plurality of aperture, and this pad is covered with a cotton layer, described cotton layer is covered with a packing layer; Described bottom is communicated with a collecting pipe.
2. a kind of antibiotic purification device as claimed in claim 1, is characterized in that: the top of described bottom is equipped with a groove, and the pad between lower prop and bottom is arranged on this groove.
3. a kind of antibiotic purification device as claimed in claim 1, is characterized in that: described lock cell comprises the first locking mechanism, and this first locking mechanism comprises a plurality of first recess, a plurality of first bayonet socket and a plurality of first locking piece; Described first recess, the first bayonet socket are located at the edge of described top cover and the edge of feed end respectively; Described first locking piece is located at below described feed end, and described first recess, the first bayonet socket, the first locking piece one_to_one corresponding are arranged, and the first locking piece blocks described top cover by described first recess, the first bayonet socket.
4. a kind of antibiotic purification device as claimed in claim 1, is characterized in that: described lower prop has a discharging opening; Described lock cell also comprises the second locking mechanism, and this second locking mechanism comprises a plurality of second recess, a plurality of second bayonet socket and a plurality of second locking piece; Described second recess, the second bayonet socket are located at the edge of described discharging opening and the lateral edges on bottom top respectively; Described second locking piece is positioned at the top of described discharging opening; Described second recess, the second bayonet socket, the second locking piece one_to_one corresponding are arranged, and the second locking piece blocks described bottom by described second recess, the second bayonet socket.
5. a kind of antibiotic purification device as claimed in claim 1, is characterized in that: the height of described column body is 4:1 with internal diameter ratio.
6. a kind of antibiotic purification device as claimed in claim 1, is characterized in that: the height of described lower prop is 15:1 with internal diameter ratio.
7. a kind of antibiotic purification device as claimed in claim 1, is characterized in that: described top cover is also provided with a bleeder pipe.
8. a kind of antibiotic purification device as claimed in claim 1, it is characterized in that: described bottom is also communicated with a sewer pipe, this sewer pipe is provided with a switch.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210529782.9A CN103007578B (en) | 2012-12-10 | 2012-12-10 | Antibiotic purifying device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210529782.9A CN103007578B (en) | 2012-12-10 | 2012-12-10 | Antibiotic purifying device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103007578A CN103007578A (en) | 2013-04-03 |
| CN103007578B true CN103007578B (en) | 2015-07-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210529782.9A Active CN103007578B (en) | 2012-12-10 | 2012-12-10 | Antibiotic purifying device |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5089125A (en) * | 1990-02-20 | 1992-02-18 | Hart Robert L | Chromatography column with sealing arrangement |
| CN201346410Y (en) * | 2008-12-30 | 2009-11-18 | 南京师范大学 | Continuous middle-pressure post tomographic separation facility |
| CN102062765A (en) * | 2009-11-16 | 2011-05-18 | 中国科学院大连化学物理研究所 | Column head structure of conical preparative liquid chromatographic column |
| CN102284193A (en) * | 2011-06-12 | 2011-12-21 | 崔建 | Exchange column for production of resin product |
| CN102527089A (en) * | 2012-02-01 | 2012-07-04 | 中国矿业大学 | Multi-segment chromatographic column |
| CN202961967U (en) * | 2012-12-10 | 2013-06-05 | 福建省微生物研究所 | Antibiotic purifying device |
-
2012
- 2012-12-10 CN CN201210529782.9A patent/CN103007578B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5089125A (en) * | 1990-02-20 | 1992-02-18 | Hart Robert L | Chromatography column with sealing arrangement |
| CN201346410Y (en) * | 2008-12-30 | 2009-11-18 | 南京师范大学 | Continuous middle-pressure post tomographic separation facility |
| CN102062765A (en) * | 2009-11-16 | 2011-05-18 | 中国科学院大连化学物理研究所 | Column head structure of conical preparative liquid chromatographic column |
| CN102284193A (en) * | 2011-06-12 | 2011-12-21 | 崔建 | Exchange column for production of resin product |
| CN102527089A (en) * | 2012-02-01 | 2012-07-04 | 中国矿业大学 | Multi-segment chromatographic column |
| CN202961967U (en) * | 2012-12-10 | 2013-06-05 | 福建省微生物研究所 | Antibiotic purifying device |
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| Publication number | Publication date |
|---|---|
| CN103007578A (en) | 2013-04-03 |
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