CN1972928A - 制备用于制备依美拉唑钠盐的结晶修饰物的新方法 - Google Patents

制备用于制备依美拉唑钠盐的结晶修饰物的新方法 Download PDF

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Publication number
CN1972928A
CN1972928A CNA2005800208742A CN200580020874A CN1972928A CN 1972928 A CN1972928 A CN 1972928A CN A2005800208742 A CNA2005800208742 A CN A2005800208742A CN 200580020874 A CN200580020874 A CN 200580020874A CN 1972928 A CN1972928 A CN 1972928A
Authority
CN
China
Prior art keywords
sodium salt
esomeprazole
esomeprazole sodium
modification
ray powder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2005800208742A
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English (en)
Chinese (zh)
Inventor
M·博哈林
U·诺雷兰德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN1972928A publication Critical patent/CN1972928A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNA2005800208742A 2004-06-24 2005-06-20 制备用于制备依美拉唑钠盐的结晶修饰物的新方法 Pending CN1972928A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58261704P 2004-06-24 2004-06-24
US60/582,617 2004-06-24

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN2013100244957A Division CN103121992A (zh) 2004-06-24 2005-06-20 制备用于制备艾美拉唑钠盐的结晶修饰物的新方法
CN201410063477.4A Division CN103772360A (zh) 2004-06-24 2005-06-20 制备用于制备艾美拉唑钠盐的结晶修饰物的新方法

Publications (1)

Publication Number Publication Date
CN1972928A true CN1972928A (zh) 2007-05-30

Family

ID=35782078

Family Applications (3)

Application Number Title Priority Date Filing Date
CNA2005800208742A Pending CN1972928A (zh) 2004-06-24 2005-06-20 制备用于制备依美拉唑钠盐的结晶修饰物的新方法
CN201410063477.4A Pending CN103772360A (zh) 2004-06-24 2005-06-20 制备用于制备艾美拉唑钠盐的结晶修饰物的新方法
CN2013100244957A Pending CN103121992A (zh) 2004-06-24 2005-06-20 制备用于制备艾美拉唑钠盐的结晶修饰物的新方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201410063477.4A Pending CN103772360A (zh) 2004-06-24 2005-06-20 制备用于制备艾美拉唑钠盐的结晶修饰物的新方法
CN2013100244957A Pending CN103121992A (zh) 2004-06-24 2005-06-20 制备用于制备艾美拉唑钠盐的结晶修饰物的新方法

Country Status (12)

Country Link
US (1) US8658799B2 (enExample)
EP (1) EP1765806A1 (enExample)
JP (2) JP5457632B2 (enExample)
KR (2) KR20130038949A (enExample)
CN (3) CN1972928A (enExample)
AU (1) AU2005257709C1 (enExample)
BR (1) BRPI0512522A (enExample)
CA (1) CA2570795C (enExample)
HK (1) HK1197065A1 (enExample)
MX (1) MXPA06015031A (enExample)
NZ (1) NZ551970A (enExample)
WO (1) WO2006001753A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102746272A (zh) * 2012-04-11 2012-10-24 江苏奥赛康药业股份有限公司 一种埃索美拉唑钠多晶型物及其制备方法和应用

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8247566B2 (en) * 2005-06-08 2012-08-21 Lek Pharmaceuticals D.D. Crystalline solvate of omeprazole sodium
WO2007055178A1 (ja) * 2005-11-08 2007-05-18 Japan Health Sciences Foundation 細胞の分取方法、及び当該方法に用いる基材
US8063074B2 (en) 2006-05-04 2011-11-22 Dr. Reddy's Laboratories Limited Polymorphic forms of esomeprazole sodium
EP2143722A1 (en) 2008-07-09 2010-01-13 Lek Pharmaceuticals D.D. Process for preparation of esomeprazole sodium of high chemical purity and new forms of esomeprazole sodium
ES2523921T3 (es) 2010-02-12 2014-12-02 Esteve Química, S.A. Procedimiento de preparación de la sal sódica de esomeprazol
CN102746273A (zh) * 2012-05-29 2012-10-24 江苏奥赛康药业股份有限公司 一种埃索美拉唑钠多晶型物及其在注射用药物中的应用
CN104031032B (zh) * 2014-07-04 2016-04-27 江苏奥赛康药业股份有限公司 一种埃索美拉唑钠化合物及其药物组合物

Family Cites Families (20)

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US4378974A (en) 1982-06-09 1983-04-05 Allis-Chalmers Corporation Start-up method for coal gasification plant
SE8301182D0 (sv) 1983-03-04 1983-03-04 Haessle Ab Novel compounds
NZ244301A (en) * 1991-09-20 1994-08-26 Merck & Co Inc Preparation of 2-pyridylmethylsulphinylbenzimidazole and pyridoimidazole derivatives from the corresponding sulphenyl compounds
US6875872B1 (en) 1993-05-28 2005-04-05 Astrazeneca Compounds
SE9301830D0 (sv) * 1993-05-28 1993-05-28 Ab Astra New compounds
WO1995032957A1 (en) * 1994-05-27 1995-12-07 Astra Aktiebolag Novel ethoxycarbonyloxymethyl derivatives of substituted benzimidazoles
SE504459C2 (sv) 1994-07-15 1997-02-17 Astra Ab Förfarande för framställning av substituerade sulfoxider
SE510666C2 (sv) * 1996-12-20 1999-06-14 Astra Ab Nya Kristallmodifikationer
SE510650C2 (sv) 1997-05-30 1999-06-14 Astra Ab Ny förening
SE510643C2 (sv) 1997-06-27 1999-06-14 Astra Ab Termodynamiskt stabil omeprazol natrium form B
NL1007699C2 (nl) 1997-12-04 1999-06-09 Medisize Bv Beademingssysteem.
SE9900274D0 (sv) * 1999-01-28 1999-01-28 Astra Ab New compound
KR100712039B1 (ko) * 1999-08-26 2007-04-27 에이에이아이파머 인코포레이티드 알콕시로 치환된 벤즈이미다졸 화합물, 상기 화합물을포함하는 약학적 제제, 및 상기 화합물의 이용방법
AU2001276721A1 (en) 2000-08-04 2002-02-18 Takeda Chemical Industries Ltd. Salts of benzimidazole compound and use thereof
AU2003262375A1 (en) 2002-04-22 2003-11-03 Sun Pharmaceutical Industries Limited Optically active substituted pyridinylmethyl-sulphinyl-benzimidazole and salts
US7169793B2 (en) * 2002-06-27 2007-01-30 Dr. Reddy's Laboratories Limited Process for preparation of optically pure or optically enriched sulfoxide compounds, including amorphous esomeprazole and salts thereof
US20040235903A1 (en) 2002-10-22 2004-11-25 Khanna Mahavir Singh Amorphous form of esomeprazole salts
MXPA05005762A (es) * 2002-12-06 2005-08-16 Altana Pharma Ag Procedimiento para preparar compuestos activos opticamente puros.
WO2004089935A1 (en) * 2003-04-10 2004-10-21 Hetero Drugs Limitd Novel crystalline forms of s-omeprazole magnesium
US7683177B2 (en) 2003-06-10 2010-03-23 Teva Pharmaceutical Industries Ltd Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102746272A (zh) * 2012-04-11 2012-10-24 江苏奥赛康药业股份有限公司 一种埃索美拉唑钠多晶型物及其制备方法和应用
CN102746272B (zh) * 2012-04-11 2014-06-25 江苏奥赛康药业股份有限公司 一种埃索美拉唑钠多晶型物及其制备方法和应用

Also Published As

Publication number Publication date
US8658799B2 (en) 2014-02-25
CN103121992A (zh) 2013-05-29
NZ551970A (en) 2010-01-29
HK1197065A1 (en) 2015-01-02
KR20130038949A (ko) 2013-04-18
KR20130140918A (ko) 2013-12-24
JP2012246316A (ja) 2012-12-13
AU2005257709A1 (en) 2006-01-05
AU2005257709B2 (en) 2008-11-13
JP5457632B2 (ja) 2014-04-02
CA2570795A1 (en) 2006-01-05
JP2008503574A (ja) 2008-02-07
AU2005257709C1 (en) 2011-02-24
WO2006001753A1 (en) 2006-01-05
CA2570795C (en) 2013-05-28
CN103772360A (zh) 2014-05-07
BRPI0512522A (pt) 2008-03-11
MXPA06015031A (es) 2007-02-08
EP1765806A1 (en) 2007-03-28
US20080039503A1 (en) 2008-02-14

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