CN1966033A - Medicament for treating eyelid ptosis and myasthenia gravis and method for preparing same - Google Patents
Medicament for treating eyelid ptosis and myasthenia gravis and method for preparing same Download PDFInfo
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Abstract
Disclosed is a medicament for treating eyelid flagging and myasthenia gravis and its preparing process, wherein the medicament is prepared from ligustrum japonicum, rhizoma dioscoreae, fresh ginger, haw, white atractylodes rhizome, pilose asiabell root, medicated leaven, and germinated barley by a predetermined weight proportions. The composition can be prepared into any of the conventional oral administration preparation by employing the conventional methods for preparing traditional Chinese medicinal preparation such as pills, capsules, tablets or oral liquids.
Description
[technical field] the present invention relates to a kind of medicine for the treatment of blepharoptosis, myasthenia gravis and preparation method thereof, belongs to technical field of Chinese medicines.
[background technology] eyes are visual organ of one of human body face, are mainly used in reading, look thing, and extraneous environment, object are reacted to brain by eyes, are convenient to brain things to external world and make respective reaction.Eyes mainly are made up of eyeball, eyelid.Eyelid can sagging and last fast receipts, are mainly used to protect eyeball, and when external dust, rainwater or other foreign bodies might injure eyeball, eyelid can be sagging immediately, closes eyes, and dust, rainwater or foreign body retaining outside eyeball, then, are gone up automatically and received.The eyelid of normal person's eyes can be normally sagging and last receipts fast, in case eyelid is suffered from myasthenia gravis after being ill, the upper eyelid just is in half always and hangs down or hang fully, difficulty in opening the eyes or at all do not see things, not only influence face appearance, more will influence study and work.
At present, the world of medicine yet there are no specific medicament to the disease of blepharoptosis, and generally only adopt expectant treatment: the traditional Chinese medical science is used BUZHONG YIQI WAN always, doctor trained in Western medicine hormone drug commonly used or operative treatment, the Chinese medicine effect is undesirable, and Western medicine such as pyridostigmine then can only be kept and can not effect a radical cure, and also has serious negative interaction.
[summary of the invention] in order to effect a radical cure the disease of blepharoptosis, the inventor has found a kind of medium-height grass prescription that can effect a radical cure myasthenia gravis finally, thereby has finished the present invention through research and clinical trial for many years.
Purpose of the present invention just provides a kind of Chinese medicine composition of a kind of more efficiently treatment blepharoptosis, myasthenia gravis.Another object of the present invention provides the method for this treatment blepharoptosis of preparation, myasthenia gravis medicine.
Medicament selection Fructus Ligustri Lucidi of the present invention, Rhizomadioscoreae, Alpinia japonica (Thunb.) Miq., Fructus Crataegi, the Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, Massa Medicata Fermentata and Fructus Hordei Germinatus make up, and with these thing medicine combinations, make each efficacy of drugs produce synergism, thereby can effectively treat the sagging disease in upper eyelid.Wherein select Fructus Ligustri Lucidi to be because liver, stomach warp, replenishing kidney-YIN, nourishing the liver to improve visual acuity are put down, returned to Fructus Ligustri Lucidi nature and flavor hardship, be used for the treatment of dizziness and tinnitus, two blurred visions paste, early whitening of beard and hair, the deficiency of the kidney seminal emission.The Rhizomadioscoreae nature and flavor are sweet flat, return the lung spleen channel, tonifying the spleen and stomach, and the lung benefiting kidney is used for the treatment of the tired Mental fatigue of body, spleen damages of suffering from a deficiency of the kidney, diet reduces, and is used for diarrhea due to hypofunction of the spleen, deficiency of both lung and spleen, loss of appetite, chronic cough, health is become thin, and is spiritual sleepy.Alpinia japonica (Thunb.) Miq., another name Herba Polygoni Runcinati, Rhizoma alpiniae pumilae, JIZHUALIAN, property and flavor of peppery and warm, regulating QI to relieve pain, promoting blood circulation to remove obstruction in the collateral; Another kind of Alpinia japonica (Thunb.) Miq. another name is small bell dish, allamanda cyanines, Rhizoma Polygonati Odorati, and nature and flavor are sweet puts down, is slightly cold, and returns lung stomach warp, nourishing YIN to relieve dryness, invigorating middle warmer stomach function regulating, nourishing the stomach to promote the production of body fluid.Fructus Crataegi: the sweet tepor of nature and flavor acid, return the taste Liver Channel, be used for the treatment of dysentery, stomachache is had loose bowels, food stops inner product, dissipating blood stasis is capable to stagnate, puerperal stasis of blood pain, lochiorrhea, the stasis of blood stagnates and loses blood the hernia swelling and hanging down of either of the testes.The Rhizoma Atractylodis Macrocephalae: property bitter but sweet flavor temperature, return the taste warp, the spleen strengthening and damp drying, inducing diuresis to remove edema is used for stagnation of dampness due to deficiency of the spleen, eats asthenia less, and abdominal distention is had loose bowels, retention of water-damp in the body, phlegm retention edema.The Radix Codonopsis nature and flavor are sweet flat, return the spleen lung meridian, invigorating the spleen to benefit the lung, and vigorate qi and replenish the blood cures mainly deficiency of vital energy deficiency, fatigue and weakness, dyspnea with rapid breath, insufficiency of the spleen lack of appetite, the edema of the face, deficiency of both QI and blood such as chronic diarrhea proctoptosis.Massa Medicata Fermentata: nature and flavor are sweet, hot, warm, return the taste warp, are used to the circulation of qi promoting that helps digestion, and invigorating the spleen to arrest diarrhea is induced sweat and is good for the stomach.Fructus Hordei Germinatus: nature and flavor are salty flat, clear food and in, galactopoiesis, be used for food stagnation and stagnate vexed, the weakness of the spleen and stomach of gastral cavity abdominal distention, inappetence.
In order to reach better therapeutic, the present invention also makes up with Poria, Semen Euryales, heart of a lotus seed Qian Ren, Fructus Jujubae, the Radix Astragali, and this is because the Poria nature and flavor are sweet flat, GUIXIN, lung taste kidney channel, promoting diuresis to eliminate damp pathogen, spleen invigorating and in, the dissipating fluid-retention that reduces phlegm, mind tranquilizing and the heart calming, notes are controlled dysuria, the edema lack of appetite, and gastral cavity is vexed, have loose bowels in the loose stool, phlegm retention is stagnated, and cough with dyspnea is uncomfortable in chest, palpitation and insomnia.The Semen Euryales sweet-puckery flavor is flat, returns the spleen kidney channel, supplementing the kidney to control the nocturnal, and invigorating the spleen to arrest diarrhea, damp eliminating ends stagnant.Semen Coicis, the property slightly sweet flavor is slightly cold, and returns the taste lung meridian, promoting diuresis to eliminate damp pathogen, the damp eliminating eliminating impediment, row is dense in lung heat clearing, invigorating the spleen to arrest diarrhea.The Fructus Jujubae nature and flavor are sweet flat, return spleen channel, invigorating the spleen and replenishing QI, and foster battalion calms the nerves, and the hemopoietic of enriching blood relaxes the property of medicine.The sweet tepor of Radix Astragali nature and flavor is returned the spleen lung meridian, tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, holder skin ulcer granulation promoting.
The consumption of drug component of the present invention also sums up out through inventor's long-felt, each amounts of components all has better curative effect in the following weight parts scope: 5～9 parts of Fructus Ligustri Lucidi, 5～16 parts of Rhizomadioscoreae, 3～10 parts of Alpinia japonica (Thunb.) Miq.s, 1.5～7 parts of Fructus Crataegis, 1～7 part of the Rhizoma Atractylodis Macrocephalae, 3～10 parts of Radix Codonopsis, 1～5 part of Massa Medicata Fermentata, 3～8 parts in Fructus Hordei Germinatus.
Be preferably: 7 parts of Fructus Ligustri Lucidi, 10 parts of Rhizomadioscoreae, 5 parts of Alpinia japonica (Thunb.) Miq.s, 5 parts of Fructus Crataegis, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Radix Codonopsis, 2 parts of Massa Medicata Fermentata, 3 parts in Fructus Hordei Germinatus.
Each amounts of components of medicine of the present invention can also be: 5～7 parts of Fructus Ligustri Lucidi, 5～16 parts of Rhizomadioscoreae, 3～10 parts of Alpinia japonica (Thunb.) Miq.s, 1.5～7 parts of Fructus Crataegis, 1～7 part of the Rhizoma Atractylodis Macrocephalae, 3～10 parts of Radix Codonopsis, 1～5 part of Massa Medicata Fermentata, 3～8 parts in Fructus Hordei Germinatus, 3～7 parts in Poria, 3～8 parts of Semen Euryaless, 10～25 parts of Semen Coiciss, 1～7 part in Fructus Jujubae, 1～3 part of the Radix Astragali.
Be preferably: 7 parts of Fructus Ligustri Lucidi, 10 parts of Rhizomadioscoreae, 5 parts of Fructus Crataegis, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Radix Codonopsis, 2 parts of Massa Medicata Fermentata, 3 parts in Fructus Hordei Germinatus, 5 parts in Poria, 5 parts of Semen Euryaless, 15 parts of Semen Coiciss, 4 parts in Fructus Jujubae, 2 parts of the Radixs Astragali.
The preparation method of medicine of the present invention comprises the steps: promptly to get all the ready earlier each required raw medicinal material, again each raw material is concocted processing respectively, distinguish pulverize then, remix is even, add the required various conventional adjuvant of different form of Chinese drug at last, as disintegrating agent, lubricant, binding agent, be prepared into any peroral dosage form commonly used, as pill, powder, tablet, capsule or oral liquid etc.
Medicine of the present invention has invigorating the spleen and replenishing QI, tonifying Qi and lifting yang, strengthening the spleen and nourishing the stomach, help digestion and in, eliminate the function of asthenia and vision enhancing, cure mainly the blepharoptosis, the myasthenia gravis that cause by internal organs such as liver,spleen,kidney, lungs, make eyes can not on disease such as open.
Medicine of the present invention proves that by medicine research, clinical practice this medicine has no side effect, and can guarantee drug safety, and effective percentage can reach more than 90%.
[specific embodiment] below by the preparation method of clinical observation test and pill, capsule etc., the present invention is further described.
One, the clinical observation of medicine of the present invention (pill) treatment blepharoptosis myasthenia gravis.
1, physical data:
Accept patient's 20 examples altogether for medical treatment, male's 8 examples wherein, women's 12 examples, 4～8 years old 13 age example, 9～18 years old 7 example, be learn before or middle and elementary school student.
2, diagnostic criteria:
The tcm diagnosis standard: according to picture of the tongue and the pulse condition and the blepharoptosis diplopia and heavy towards light dusk of traditional Chinese medical science the four methods of diagnosis and eight key links, taste are deficient, and yang deficiency is weak, is diagnosed as blepharoptosis.
The Western medicine diagnose standard, the eyes muscular fatigue test is positive, the long 3mm that surpasses of eyelid, the ocular movemeut sluggishness, but not limited, be diagnosed as myasthenia gravis.
3, Therapeutic Method
Adopt pill medicine of the present invention.Oral 3 times of every day, take 5～10g pill at every turn, three months is a course of treatment, but 3～4 rehabilitations course of treatment of logotype.
4, efficacy assessment standard
Complete: every kind of transference cure, eyes can normally be seen thing and open automatically and close, and observe and do not recur after 3 months.
Effectively: symptom disappears substantially, can normally see thing, but eyes are opened and closed also not really freely.
Invalid: symptom is not improved, and does not reach effective treatment standard.
5, therapeutic outcome (seeing the following form)
| Treatment time (moon) | Complete | Effectively | Invalid | Total effective rate | |||
| The example number | Ratio | The example number | Ratio | The example number | Ratio | ||
| 1 | 15 | 75％ | 5 | 25％ | 75％ | ||
| 2 | 18 | 90％ | 2 | 10％ | 90％ | ||
| 3 | 20 | 100％ | 0 | 100％ | |||
| 6 | 10 | 50％ | 10 | 50％ | 0 | 100％ | |
| 9 | 15 | 75％ | 5 | 25％ | 0 | 100％ | |
| 12 | 20 | 100％ | 0 | 0 | 100％ |
In a word, with pill Drug therapy 20 examples of the present invention, taking medicine 6 months the time, recovery rate 50% was taken medicine 9 months the time, and recovery rate 75% is taken medicine 12 months the time recovery rate 100%, total effective rate 100%.
6, model case
Case 1: Zhang Fan, woman, Anfu township, Anxiang County, Hunan Province rim of the mouth, pool people from village, in JIUYUE, 1987 birth.Half trouble eyelid was sagging in 3 years old, serious lucifuge disease.Diagnosis and treatment 14 years, earlier after Jinshi City Anxiang County, Hunan Province, the People's Hospital, Nan County ophthalmology and Annex II hospital of Hunan Medical University, the attached hospital ophthalmology of Guangzhou TCM Universities are received treatment, effect is very undesirable.Come this institute to treat at the beginning of 2003.According to the diagnosis of large hospital with at that time the patient was carried out the four methods of diagnosis and eight key links, it is seriously sagging to be defined as the deficient type eyelid of taste.Use pill of the present invention, every day 3 times, each 10g, after one month, the state of an illness is clearly better, and heals entirely in the time of 6 months, does not send out so far.
Case 2: Chen Qin, the woman, Yu Depu town, Hanshou county, Hunan Province Mao Jiachong people studied in the primary school at 12 years old six grades the time, the discovery eye is opened not open, partly narrowing, arriving this province Hanshou County People's Hospital subsequently, be diagnosed as " myasthenia gravis " and opened a little pyridostigmine Western medicine, returned the Chinese medicine pill of a little invigorating the spleen and replenishing QI, eat many bottles of medicines, do not felt any better, come this institute to treat.Use pill of the present invention, every day 3 times, each 10g, when serveing on one and a half months, eyes just can have been opened, and have continued to eat one month pill, and disease has just healed entirely, past 10 years, do not send out so far.
Case 3: repair auspicious literary composition, the man, Yu Depu people from town, Hanshou county, Hunan Province, 14 years old, it is sagging that suffer from right eyelid in August, 2000, successively, eat pyridostigmine and BUZHONG YIQI WAN medicine, DeGrain to Hanshou County People's Hospital and the treatment of Hanshou county institute of traditional Chinese medicine, after arrive Annex II institute of the refined hospital in First People's Hospital, Changde City and Hunan, Hunan treatment again, be diagnosed as myasthenia gravis, the expert says and can only keep treatment, can not effect a radical cure.In August, 2004, to the People's Hospital, Hanshou operative treatment, things turn out contrary to one's wishes for the result, and the state of an illness increases the weight of, left and right sides eyes all can not on opened, and to cover half eyeball, have a strong impact on vision.Treat after 8 years the state of an illness and do not feel any better, treat to this institute, take pill of the present invention in January, 2006, every day 3 times, each 10g pill, after 6 months, each 5g is healed after 8 months entirely, and eyes can be as the normal person, normally opens to close and seen thing.
Two, the preparation method of medicine of the present invention:
Embodiment 1: the preparation method of the medicine pill of treatment blepharoptosis is as follows:
1. get all the Chinese crude drug of respectively distinguishing the flavor of ready by prescription;
2. each Chinese crude drug is concocted in processing respectively;
Wherein: Fructus Ligustri Lucidi is wild crude drug, carries out nine after the roguing and steams nine solarization processing;
To Alpinia japonica (Thunb.) Miq.: get bright medical material, go silt to clean, go carefully must dry, rub, dry after the section with hand rubbing;
To Rhizomadioscoreae: need get wild Rhizomadioscoreae, after the roguing, section is dried in the shade;
To Fructus Crataegi: roguing, clean draw down after, drying;
To the Rhizoma Atractylodis Macrocephalae: get the crude drug roguing, soak 6 seventy percent and take out when saturating, moistening when consistent, is cut sheet, drying to inside and outside humidity;
To Radix Codonopsis: get crude drug, roguing is cleaned, and runs through, and cuts sheet, drying;
To Fructus Hordei Germinatus: get clean Fructus Hordei Germinatus and fry to buff with slow fire in pot, during little heaving or when explosive sound is arranged, taking-up cools;
To Poria: get wild natural Poria, roguing is cut into small pieces and dries, mix Poria with Cinnabaris 2% after, get the clean sheet of Poria;
To Semen Euryales: add to propagandize hotly with slow fire and fry when smoldering, add Semen Euryales and stir fast, fry to surperficial pale brown color taking-up Semen Euryales airing to the Semen Euryales pale brown color in surface or with wheat bran moderate heat in pot;
To Semen Coicis: fry when smoldering with moderate heat in pot with wheat bran, pour Semen Coicis into, fry to the surface yellowly, when heaving, take out, sieve removes wheat bran, airing.
3. with each Chinese crude drug pulverize separately, cross 80 mesh sieves;
4. mix and mix thoroughly, each Chinese medicinal powder is mixed mix thoroughly;
5. molding, each Chinese medicinal powder after mixing mixed thoroughly adds an amount of cold water or adds proper honey again, is in harmonious proportion the back to be shaped to pill in pelletize, and every pill heavily is 0.1～0.5g.
6. packing is put in storage.
Embodiment 2: the Chinese medicinal capsule of treatment blepharoptosis, and its preparation method is as follows:
1.～4. with embodiment 1 1.～4.;
5. molding: each Chinese medicinal powder after mixing mixed thoroughly, in the snap fit capsule of packing into, adorn 0.1～0.2g Chinese medicinal powder for every.
6. packing is put in storage.
Claims (6)
1, the medicine of a treatment blepharoptosis, myasthenia gravis, it is characterized in that: it mainly is to be made by following bulk drugs: 5～9 parts of Fructus Ligustri Lucidi, 5～16 parts of Rhizomadioscoreae, 3～10 parts of Alpinia japonica (Thunb.) Miq.s, 1.5～7 parts of Fructus Crataegis, 1～7 part of the Rhizoma Atractylodis Macrocephalae, 3～10 parts of Radix Codonopsis, 1～5 part of Massa Medicata Fermentata, 3～8 parts in Fructus Hordei Germinatus.
2, according to the described medicine of claim 1, it is characterized in that: wherein the consumption of each crude drug is: 7 parts of Fructus Ligustri Lucidi, 10 parts of Rhizomadioscoreae, 5 parts of Alpinia japonica (Thunb.) Miq.s, 5 parts of Fructus Crataegis, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Radix Codonopsis, 2 parts of Massa Medicata Fermentata, 3 parts in Fructus Hordei Germinatus.
3, medicine according to claim 1 is characterized in that: wherein material medicine also has 3～7 parts in Poria, 3～8 parts of Semen Euryaless, 10～25 parts of Semen Coiciss, 1～7 part in Fructus Jujubae, 1～3 part of the Radix Astragali.
4, according to claim 1 or 3 described medicines, it is characterized in that: wherein the consumption of each crude drug is: 5 parts in Poria, 5 parts of Semen Euryaless, 15 parts of Semen Coiciss, 4 parts in Fructus Jujubae, 2 parts of the Radixs Astragali.
5, according to the preparation method of the described medicine of claim 1～4, it is characterized in that: it comprises the steps: to get all the ready earlier each raw medicinal material, again each raw material medicine is concocted processing respectively, distinguish pulverize then, cross 80 mesh sieves, remix is even, adds the required various conventional adjuvant of different Chinese medicine preparation at last, is prepared into the medicine of any peroral dosage form commonly used.
6, according to the described preparation method of claim 5, it is characterized in that: in the described raw medicinal material, Fructus Ligustri Lucidi is wild crude drug, after the roguing, carries out nine and steams nine solarization processing; Rhizomadioscoreae is natural crude drugs, and section is dried in the shade after the roguing;
Alpinia japonica (Thunb.) Miq.: get bright medical material, go silt to clean, go carefully must dry, be used for rubbing, dry after the section;
Fructus Crataegi: behind roguing, the clean draw down, drying;
The Rhizoma Atractylodis Macrocephalae: the crude drug roguing, to soak 6 seventy percent and take out when saturating, stewing profit when consistent, is cut sheet, drying to inside and outside humidity;
Radix Codonopsis: crude drug, roguing, clean, run through, cut sheet, drying;
Fructus Hordei Germinatus: get clean Fructus Hordei Germinatus and in pot, fry to buff, during little heaving or when explosive sound is arranged, take out airing with slow fire;
Poria: get wild natural Poria, roguing is cut into small pieces, mix Poria with Cinnabaris 2% after, get the clean sheet of Poria;
Semen Euryales: get crude drug and add with slow fire and propagandize to pale brown color in Semen Euryales surface or wheat bran moderate heat in pot hotly and fry when smoldering, add Semen Euryales and stir fast, take out the Semen Euryales airing when frying to surperficial pale brown color;
Semen Coicis: get crude drug and fry when smoldering with slow fire in pot with wheat bran, pour Semen Coicis into and fry yellowly and when heaving to the surface, take out, sieve removes wheat bran, airing.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2006100323431A CN100522233C (en) | 2006-09-26 | 2006-09-26 | Medicament for treating eyelid ptosis and myasthenia gravis and method for preparing same |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2006100323431A CN100522233C (en) | 2006-09-26 | 2006-09-26 | Medicament for treating eyelid ptosis and myasthenia gravis and method for preparing same |
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| CN1966033A true CN1966033A (en) | 2007-05-23 |
| CN100522233C CN100522233C (en) | 2009-08-05 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104147456A (en) * | 2014-08-27 | 2014-11-19 | 中南林业科技大学 | Decoction for treating ocular myasthenia gravis |
| CN104147455A (en) * | 2014-08-27 | 2014-11-19 | 中南林业科技大学 | Preparation for treating ocular myasthenia gravis |
| CN104147277A (en) * | 2014-08-29 | 2014-11-19 | 郑树旺 | Traditional Chinese medicinal preparation for treating myasthenia gravis and preparation method |
| CN104173853A (en) * | 2014-09-12 | 2014-12-03 | 中南林业科技大学 | Drug for treating ocular myasthenia gravis |
| CN104547369A (en) * | 2015-02-07 | 2015-04-29 | 成都市飞龙水处理技术研究所青白江第一分所 | Oral medicine for treating blepharospasm and preparation method thereof |
| CN104623130A (en) * | 2015-02-08 | 2015-05-20 | 成都市飞龙水处理技术研究所青白江第一分所 | Oral medicine capable of treating blepharoptosis and preparation method of oral medicine |
| CN106938039A (en) * | 2017-03-29 | 2017-07-11 | 卢仁华 | The medicine of ptosis |
-
2006
- 2006-09-26 CN CNB2006100323431A patent/CN100522233C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104147456A (en) * | 2014-08-27 | 2014-11-19 | 中南林业科技大学 | Decoction for treating ocular myasthenia gravis |
| CN104147455A (en) * | 2014-08-27 | 2014-11-19 | 中南林业科技大学 | Preparation for treating ocular myasthenia gravis |
| CN104147277A (en) * | 2014-08-29 | 2014-11-19 | 郑树旺 | Traditional Chinese medicinal preparation for treating myasthenia gravis and preparation method |
| CN104173853A (en) * | 2014-09-12 | 2014-12-03 | 中南林业科技大学 | Drug for treating ocular myasthenia gravis |
| CN104547369A (en) * | 2015-02-07 | 2015-04-29 | 成都市飞龙水处理技术研究所青白江第一分所 | Oral medicine for treating blepharospasm and preparation method thereof |
| CN104623130A (en) * | 2015-02-08 | 2015-05-20 | 成都市飞龙水处理技术研究所青白江第一分所 | Oral medicine capable of treating blepharoptosis and preparation method of oral medicine |
| CN106938039A (en) * | 2017-03-29 | 2017-07-11 | 卢仁华 | The medicine of ptosis |
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| CN100522233C (en) | 2009-08-05 |
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