CN1961959A - Method for preparing hollow fiber with temperature sensitive medicinal hydrogel and application thereof - Google Patents
Method for preparing hollow fiber with temperature sensitive medicinal hydrogel and application thereof Download PDFInfo
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- CN1961959A CN1961959A CNA2006101179531A CN200610117953A CN1961959A CN 1961959 A CN1961959 A CN 1961959A CN A2006101179531 A CNA2006101179531 A CN A2006101179531A CN 200610117953 A CN200610117953 A CN 200610117953A CN 1961959 A CN1961959 A CN 1961959A
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Abstract
The invention relates to a method for preparing temperature-sensitive aquagel hollow fiber, wherein it uses hollow fiber as carrier, whose chamber contains temperature-sensitive aquagel; the aquagel will change phase at human temperature to release the drug. And the preparation comprises a, holding the holes of hollow fiber; b, putting temperature-sensitive monomer solution into the chamber of hollow fiber; c, compositing temperature-sensitive aquagel in the chamber; d, using said aquagel to absorb drub. The invention has better temperature-sensitive property and slow-release property.
Description
Technical field
The present invention relates to the preparation method and the application thereof of drug temperature-sensitive carrier doughnut, be specifically related to a kind of realize temperature sensitive medicinal hydrogel doughnut that drug temperature-sensitive discharges, and its production and application.
Background technology
The treatment of various acute and chronic diseases can be achieved by the release of medicine, has formed multiple delivery systmes such as tablet, injection, suppository, ointment and aerosol at present.Yet because a variety of causes uses these common administering modes, the intravital drug level of people often can only keep the short time and fluctuation is bigger; Use low dose repeatedly medication can address this problem but can bring a lot of inconvenience to the patient, often is difficult to be accepted by the patient.Therefore, traditional drug delivery system is can not satisfy patient's demand fully, and new controlled drug delivery system has obtained increasing concern.
Drug delivery system is most important to the effect of medicine.For common administering mode, a big chunk of many medicines is owing to the first pass effect or the medicine of liver lost efficacy in the gastrointestinal degraded.Therefore,, reduce side effect, need the preparation suitable pharmaceutical carrier, develop suitable drug delivery system for utilization rate and the curative effect that improves medicine.
Drug temperature-sensitive carrier doughnut is the cavity that the pastille temperature-sensitive hydrogel is placed doughnut inside, when temperature reaches body temperature, temperature-sensitive hydrogel takes place to change mutually,, realizes the temperature of drug release is controlled with drug release with a kind of mode of extruding of being similar to.This drug delivery system does not at home and abroad appear in the newspapers at present as yet, has important practical to be worth for the effective controllable release that realizes medicine.
Summary of the invention
The preparation method of temperature sensitive medicinal hydrogel doughnut of the present invention and application aims thereof are to provide a kind of drug release, realize the temperature control to drug release.
For reaching above-mentioned purpose, the invention provides a kind of temperature sensitive medicinal hydrogel doughnut, with the doughnut is carrier, wherein, in the internal cavities of described doughnut, contain temperature sensitive medicinal hydrogel, when reaching body temperature, described temperature-sensitive hydrogel takes place to change the d/d hydrogel of medicine mutually for a kind of.
Described doughnut is a kind of or its combination in staple fibre and the synthetic fibers, comprises synthetic fibers such as staple fibres such as cellulose acetate and polyacrylonitrile, polyester, polyamide.
A further object of the present invention is to provide a kind of preparation method of temperature sensitive medicinal hydrogel doughnut, and temperature-sensitive hydrogel is synthetic in the cavity of doughnut inside, comprises following technical process:
A, the fenestra of doughnut is protected the hole handle;
Insert temperature sensitive monomer solution in the cavity of b, doughnut inside;
C, in the cavity of doughnut inside synthetic temperature-sensitive hydrogel;
D, with this gel absorption medicine.
The described preparation that fenestra is handled doughnut comprises through protecting the hole handles back infiltration 24 hours in pure water, guarantees that the fenestra surface soaked into fully by water.
Inserting temperature sensitive monomer method in the cavity of described doughnut inside is: compound concentration is N-N-isopropylacrylamide (NIPA) the solution 300ml of 1mol/L, adds 6 * 10
-3The cross-linking agent N of mol, N ,-methylene-bisacrylamide (BIS) dissolving is evenly, at room temperature, after the doughnut of handling well soaked, take out the fiber pure water rinsing in mixed solution, remove and do not enter the doughnut internal cavities and after resting on the extra liquid of doughnut outer surface, stand-by.
The step of synthetic temperature-sensitive hydrogel comprises in the cavity of doughnut inside:
The first step: preparation contains the solution 200ml of two acrylic acid glycol ester 0.15g of cross-linking agent and initiator potassium persulfate 0.2g;
Second step: the doughnut that the first step is handled well is immersed in the solution, and heating in water bath to 70 ℃ under nitrogen protection reacts 20 minutes to a few hours, reacts completely;
The 3rd step: take out second and go on foot the fiber of handling well, clean, vacuum drying is made the doughnut that contains thermosensitive hydrogel.
The described doughnut that contains thermosensitive hydrogel is immersed in the drug solution, and wherein, the volume ratio of medicine and water is: 1.7～2.4: 1.Wherein, when using chemical medicine, adopt transdermal pharmaceutical, as a kind of or its combination in azone, oleic acid, N-N-methyl-2-2-pyrrolidone N-, propylene glycol, the Borneolum Syntheticum.
Described drug solution is (by volume): distilled water 37%, and acyclovir alcoholic solution 60%, oleic acid 3% is mixed with medicinal liquid, and the doughnut that at room temperature will contain thermosensitive hydrogel is placed in the medicinal liquid and soaks, and makes the temperature sensitive medicinal hydrogel doughnut.
Described drug solution is (by volume): distilled water 30%, and traditional Chinese medicine composition extract liquid 70% is mixed with medicinal liquid, and the doughnut that at room temperature will contain thermosensitive hydrogel is placed in the medicinal liquid and soaks, and makes the temperature sensitive medicinal hydrogel doughnut; Described Chinese medicine composition is a kind of or its compositions in Sargassum, Thallus Laminariae (Thallus Eckloniae), Spica Prunellae, the Radix Aucklandiae, Radix Paeoniae Rubra, Cortex Moutan, Radix Scrophulariae, Herba Taraxaci, Cornu Cervi, Flos Carthami, Caulis Spatholobi, the Radix Notoginseng.
Utilize the purposes of described a kind of temperature sensitive medicinal hydrogel doughnut, as the internal layer lining, make underwear or make protective pad with described doughnut.
Advantage of the present invention is:
1, safety, application method of the present invention can avoid the first pass effect of liver and medicine to degrade at gastrointestinal, the absorption of medicine is not influenced by gastrointestinal factors, the blood drug level peak valley phenomenon of having avoided oral administration etc. to cause, reduced toxicity, and interruption of the administration at any time, remove drug-supplying system after, blood drug level descends;
2, effectiveness, the product that utilizes the present invention to make has temperature-sensing property, can slowly release medicine under the temperature of body temperature, has the good slow release performance, and directly at local application, keep stable blood drug level, reach the purpose that reduces poisonous side effect of medicine and prolong drug effect;
3, comfortableness, the product that utilizes the present invention to make has identical comfortable sensation with mill run, avoid the drug smell of overrich, therefore this application method can both alleviate its painful and frightened degree than any other application methods such as oral, injection, implantation;
4, convenience, is made underwear, protective pad etc. and is used equally with mill run as the internal layer lining with the temperature sensitive medicinal hydrogel doughnut, and periodic replacement is easy to use.
Description of drawings
Fig. 1 is the schematic cross-section of temperature sensitive medicinal hydrogel doughnut of the present invention.
1-doughnut 2-temperature sensitive medicinal hydrogel
The specific embodiment
See also shown in the schematic cross-section of accompanying drawing drug temperature-sensitive carrier of the present invention doughnut, the invention will be further described.
Embodiment 1
A kind of temperature sensitive medicinal hydrogel doughnut is a carrier with doughnut 1, wherein, in the internal cavities of described doughnut 1, contain temperature sensitive medicinal hydrogel 2, when reaching body temperature, described temperature-sensitive hydrogel takes place to change the d/d hydrogel of medicine mutually for a kind of.
A kind of preparation method of temperature sensitive medicinal hydrogel doughnut, temperature sensitive medicinal hydrogel 2 are synthetic in the cavity of doughnut 1 inside, comprise following technical process:
Concrete technology is as follows:
(1) preparation of doughnut and processing: spin out the polyacrylonitrile doughnut, after protecting the hole and handling, it is immersed in the pure water 24 hours, guarantee that the fenestra surface soaked into fully by water.
(2) inserting of temperature sensitive monomer solution: compound concentration is N-N-isopropylacrylamide (NIPA) the solution 300ml of 1mol/L, adds 6 * 10
-3The cross-linking agent N of mol, N ,-methylene-bisacrylamide (BIS) dissolving evenly at room temperature is immersed in doughnut in this mixed solution 50 minutes.Take out fiber and wash gently, remove the cavity that does not enter doughnut inside and rest on after the extra liquid of doughnut outer surface stand-by with 20 ℃ pure water;
(3) temperature-sensitive hydrogel is synthetic: preparation contains the solution 200ml of two acrylic acid glycol ester 0.15g of cross-linking agent and initiator potassium persulfate 0.2g.The doughnut of handling well in (2) is immersed in the solution, and heating in water bath to 70 ℃ under nitrogen protection reacts 20 minutes to a few hours, and question response back fully takes out and cleans repeatedly with pure water, and is standby after being dried to constant weight under 40 ℃ in vacuum drying oven.
(4) medicine adsorption treatment: adopt acyclovir for containing antiviral drugs.By volume: distilled water 37%, acyclovir alcoholic solution 60%, oleic acid 3% preparating liquid, at room temperature with what handle well in (3), the doughnut that contains thermosensitive hydrogel is placed in the quantitative medicinal liquid and soaks diel, makes the temperature sensitive medicinal hydrogel doughnut.
(5) fiber post processing: wash fiber gently with pure water, at 20 ℃ of dry water of removing the doughnut outer surface in vacuum drying oven.
(6) application of doughnut: the temperature sensitive medicinal hydrogel doughnut of handling well is made the antiviral surface layer, be added on the absorbed layer in the common protective pad, obtain antivirus pad.
A kind of temperature sensitive medicinal hydrogel doughnut is a carrier with doughnut 1, wherein, in the internal cavities of described doughnut 1, contain temperature sensitive medicinal hydrogel 2, when reaching body temperature, described temperature-sensitive hydrogel takes place to change the d/d hydrogel of medicine mutually for a kind of.
The preparation method of temperature sensitive medicinal hydrogel doughnut, temperature sensitive medicinal hydrogel 2 are synthetic in the cavity of doughnut 1 inside, comprise following technical process:
(1) preparation of doughnut: spin out the cellulose acetate doughnut, after protecting the hole and handling, it is immersed in the pure water 24 hours, guarantee that the fenestra surface soaked into fully by water.
(2) inserting of temperature sensitive monomer solution: with embodiment 1.
(3) temperature-sensitive hydrogel is synthetic: with embodiment 1.
(4) preparation of medicine hydrogel: it is medicine that employing contains Chinese medicine extraction liquid.By volume: distilled water 30%, Chinese medicine (Sargassum, Thallus Laminariae (Thallus Eckloniae), Spica Prunellae, the Radix Aucklandiae, Radix Paeoniae Rubra, Cortex Moutan, Radix Scrophulariae, Herba Taraxaci, Cornu Cervi, Flos Carthami, Caulis Spatholobi, Radix Notoginseng) extracting solution 70% preparating liquid, at room temperature will handle well in (3), the doughnut that contains thermosensitive hydrogel is placed in the quantitative medicinal liquid and soaks diel, makes the temperature sensitive medicinal hydrogel doughnut.
(5) fiber post processing: with embodiment 1.
(6) application of doughnut: the temperature sensitive medicinal hydrogel doughnut of handling well is made medicated bra internal layer lining, make medicated bra according to the processing technology and the operation of common medicated bra.
Embodiment 3
A kind of temperature sensitive medicinal hydrogel doughnut is a carrier with doughnut 1, wherein, in the internal cavities of described doughnut 1, contain temperature sensitive medicinal hydrogel 2, when reaching body temperature, described temperature-sensitive hydrogel takes place to change the d/d hydrogel of medicine mutually for a kind of.The preparation method of temperature sensitive medicinal hydrogel doughnut, temperature sensitive medicinal hydrogel 2 are synthetic in the cavity of doughnut 1 inside, comprise following technical process:
(1) preparation of doughnut: spin out the polyester doughnut, after protecting the hole and handling, it is immersed in the pure water 24 hours, guarantee that the fenestra surface soaked into fully by water.
(2) inserting of temperature sensitive monomer solution: with embodiment 1.
(3) temperature-sensitive hydrogel is synthetic: with embodiment 1.
(4) preparation of medicine hydrogel: the employing mifepristone is a medicine.By volume: distilled water 37%, mifepristone alcoholic solution 60%, N-N-methyl-2-2-pyrrolidone N-3% preparating liquid at room temperature will be handled well in (3), the doughnut that contains thermosensitive hydrogel is placed in the quantitative medicinal liquid and soaks diel, makes the temperature sensitive medicinal hydrogel doughnut.
(5) fiber post processing: with embodiment 1.
(6) application of doughnut: the temperature sensitive medicinal hydrogel doughnut of handling well is made the antiviral surface layer, be added on the absorbed layer in the common protective pad protective pad of the hysteromyoma that obtains medical treatment.
Claims (10)
1, a kind of temperature sensitive medicinal hydrogel doughnut, with the doughnut is carrier, it is characterized in that: in the internal cavities of described doughnut, contain temperature sensitive medicinal hydrogel, described temperature sensitive medicinal hydrogel is a kind of when reaching body temperature, hydrogel takes place to change the d/d hydrogel of medicine mutually.
2, temperature sensitive medicinal hydrogel doughnut according to claim 1 is characterized in that: described doughnut is a kind of or its combination in staple fibre and the synthetic fibers.
3, a kind of preparation method at the described temperature sensitive medicinal hydrogel doughnut of claim 1, temperature-sensitive hydrogel are synthetic in the cavity of doughnut inside, comprise following technical process:
A, the fenestra of doughnut is protected the hole handle;
Insert temperature sensitive monomer solution in the cavity of b, doughnut inside;
C, in the cavity of doughnut inside synthetic temperature-sensitive hydrogel;
D, with this gel absorption medicine.
4, the preparation method of temperature sensitive medicinal hydrogel doughnut according to claim 3 is characterized in that: the described preparation that fenestra is handled doughnut comprises through protecting soaks in pure water after handle in the hole, guarantees that the fenestra surface soaked into fully by water.
5, the preparation method of temperature sensitive medicinal hydrogel doughnut according to claim 3, insert temperature sensitive monomer method be in the cavity of described doughnut inside: compound concentration is the N-N-isopropylacrylamide solution 300ml of 1mol/L, adds 6 * 10
-3The cross-linking agent N of mol, N, the dissolving of-methylene-bisacrylamide is evenly, at room temperature, after doughnut soaked, take out the fiber pure water rinsing in mixed solution, remove and do not enter the doughnut internal cavities and after resting on the extra liquid of doughnut outer surface, stand-by.
6, the preparation method of temperature sensitive medicinal hydrogel doughnut according to claim 3, the step of synthetic temperature-sensitive hydrogel comprises in the cavity of doughnut inside:
The first step: preparation contains the solution 200ml of two acrylic acid glycol ester 0.15g of cross-linking agent and initiator potassium persulfate 0.2g;
Second step: the doughnut that the first step is handled well is immersed in the solution, and heating in water bath to 70 ℃ reaction reacts completely under nitrogen protection;
The 3rd step: take out second and go on foot the fiber of handling well, clean, vacuum drying is made the doughnut that contains thermosensitive hydrogel.
7, the preparation method of temperature sensitive medicinal hydrogel doughnut according to claim 6 is characterized in that: the described doughnut that contains thermosensitive hydrogel is immersed in the drug solution, and wherein, the volume ratio of medicine and water is: 1.7～2.4: 1.
8, the preparation method of temperature sensitive medicinal hydrogel doughnut according to claim 7, it is characterized in that: described drug solution is (by volume): distilled water 37%, acyclovir alcoholic solution 60%, oleic acid 3% is mixed with medicinal liquid, the doughnut that at room temperature will contain thermosensitive hydrogel is placed in the medicinal liquid and soaks, and makes the temperature sensitive medicinal hydrogel doughnut.
9, the preparation method of temperature sensitive medicinal hydrogel doughnut according to claim 7, it is characterized in that: described drug solution is (by volume): distilled water 30%, traditional Chinese medicine composition extract liquid 70% is mixed with medicinal liquid, the doughnut that at room temperature will contain thermosensitive hydrogel is placed in the medicinal liquid and soaks, and makes the temperature sensitive medicinal hydrogel doughnut; Described Chinese medicine composition is a kind of or its compositions in Sargassum, Thallus Laminariae (Thallus Eckloniae), Spica Prunellae, the Radix Aucklandiae, Radix Paeoniae Rubra, Cortex Moutan, Radix Scrophulariae, Herba Taraxaci, Cornu Cervi, Flos Carthami, Caulis Spatholobi, the Radix Notoginseng.
10, utilize the purposes of the described a kind of temperature sensitive medicinal hydrogel doughnut of claim 1, as the internal layer lining, make underwear, or make protective pad with described doughnut.
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| CNB2006101179531A CN100540056C (en) | 2006-11-03 | 2006-11-03 | The preparation method of temperature sensitive medicinal hydrogel doughnut and application thereof |
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| CN100540056C CN100540056C (en) | 2009-09-16 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103469610A (en) * | 2013-09-16 | 2013-12-25 | 吴江市海丰喷织有限公司 | Multi-purpose anti-bacterial fabric |
| CN105040138A (en) * | 2015-06-08 | 2015-11-11 | 浪莎针织有限公司 | Preparation method of polyacrylonitrile hollow fiber capable of releasing acyclovir |
| US9675417B2 (en) | 2008-07-15 | 2017-06-13 | Koninklijke Philips N.V. | Safe ablation |
| CN107298768A (en) * | 2017-05-17 | 2017-10-27 | 四川大学 | A kind of preparation method of temperature response type combination switch film |
| CN109806361A (en) * | 2019-03-11 | 2019-05-28 | 浙江省立同德医院 | One kind helping pregnant Chinese materia medica preparation and herbal fomentation packet and preparation method for warming kidney and promoting blood circulation, dredging collateral |
| CN110801429A (en) * | 2019-10-25 | 2020-02-18 | 深圳大学 | Drug release fiber tube, preparation method thereof, drug controlled release stent and application |
| CN113018499A (en) * | 2021-03-08 | 2021-06-25 | 山西医科大学第一医院 | Preparation method of ozone oil-water gel composite application capable of sterilizing, resisting virus and absorbing moisture |
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2006
- 2006-11-03 CN CNB2006101179531A patent/CN100540056C/en active Active
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9675417B2 (en) | 2008-07-15 | 2017-06-13 | Koninklijke Philips N.V. | Safe ablation |
| CN103469610A (en) * | 2013-09-16 | 2013-12-25 | 吴江市海丰喷织有限公司 | Multi-purpose anti-bacterial fabric |
| CN105040138A (en) * | 2015-06-08 | 2015-11-11 | 浪莎针织有限公司 | Preparation method of polyacrylonitrile hollow fiber capable of releasing acyclovir |
| CN107298768A (en) * | 2017-05-17 | 2017-10-27 | 四川大学 | A kind of preparation method of temperature response type combination switch film |
| CN107298768B (en) * | 2017-05-17 | 2020-08-21 | 四川大学 | Preparation method of temperature response type composite switch membrane |
| CN109806361A (en) * | 2019-03-11 | 2019-05-28 | 浙江省立同德医院 | One kind helping pregnant Chinese materia medica preparation and herbal fomentation packet and preparation method for warming kidney and promoting blood circulation, dredging collateral |
| CN110801429A (en) * | 2019-10-25 | 2020-02-18 | 深圳大学 | Drug release fiber tube, preparation method thereof, drug controlled release stent and application |
| CN110801429B (en) * | 2019-10-25 | 2023-04-07 | 深圳大学 | Drug release fiber tube, preparation method thereof, drug controlled release stent and application |
| CN113018499A (en) * | 2021-03-08 | 2021-06-25 | 山西医科大学第一医院 | Preparation method of ozone oil-water gel composite application capable of sterilizing, resisting virus and absorbing moisture |
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| CN100540056C (en) | 2009-09-16 |
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