CN101148785B - Gromwell root medical polypropylene fibre for preventing and curing skin disease, preparation method and application thereof - Google Patents
Gromwell root medical polypropylene fibre for preventing and curing skin disease, preparation method and application thereof Download PDFInfo
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- CN101148785B CN101148785B CN200710047295A CN200710047295A CN101148785B CN 101148785 B CN101148785 B CN 101148785B CN 200710047295 A CN200710047295 A CN 200710047295A CN 200710047295 A CN200710047295 A CN 200710047295A CN 101148785 B CN101148785 B CN 101148785B
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Abstract
The present invention relates to one kind of polyacrylonitrile fiber with gromwell medicine for preventing and treating skin diseases and its preparation process and application. The medicinal polyacrylonitrile fiber consists of gromwell in 0.0001-30 wt%, transdermal medicine absorption promoter in 0.0001-10 wt%, and polyacrylonitrile fiber in 1-99 wt%. It is prepared through adding gromwell and transdermal medicine absorption promoter into the spinning fluid of polyacrylonitrile, and spinning to obtain the medicinal polyacrylonitrile fiber. The medicinal polyacrylonitrile fiber is applied inmaking fabric for underwear, socks, handkerchief and napkin with functions of preventing and treating skin diseases.
Description
Technical field
The invention belongs to the polyacrylonitrile fibre field, particularly relate to the dermopathic gromwell root medical polypropylene nitrile of a kind of control fiber, its preparation method and application.
Background technology
Skin disease is a kind of common disease in China, and the incidence of disease is higher, and some skin disease is difficult for radical cure, after the healing easily repeatedly.Be example with the athlete's foot that is caused by fungal infection only, the average attack rate of this disease in the whole nation just reaches about 1/3, at the higher relatively southern some areas incidence of disease of temperature and humidity even surpass 50%.To treating for skin disease, doctor trained in Western medicine is often treated by drug orals such as antihistamine, corticosteroid hormone, antibiotic and vitamins or local topical, widespread usage clinically, but because the restrictions such as side effect of himself are unfavorable for long-term large tracts of land use; The traditional Chinese medical science is paid attention to integrally-regulated, generally makes for oral administration or external application such as decoction, lotion, tincture, powder by the Chinese herbal medicine folk prescription or the prescription that some are had cooling and activating blood, eliminating inflammation and expelling toxin effect, obtains good result.But on formulation, also be difficult to overcome traditional decoction, paste, powder isotype, be difficult to realize requirement such as the contact of external used medicine is comprehensive, simple to operate.Therefore no matter the traditional Chinese medical science or doctor trained in Western medicine, patient wants frequent medication every day, has wasted a large amount of time and efforts, and brings the misery of body and mind to the patient.
Asian puccoon is the clinical simply dermopathic Chinese medicine that is usually used in treating, its main active ingredient is naphthoquinone compound, comprise alkannin (shikonin) and its derivative deoxyshikonin (deoxyshikonin), β, beta-dimethyl-acryloyl alkannin (β, β-dimethylacrylshikonin), isobutyryl shikonin (isobutylshikonin) and Acetylshikonin (structure are seen Fig. 1) such as (acetylshikonin).Chinese Pharmacopoeia (2005 editions) records it and has cooling and activating blood, and the effect of detoxifcation promoting eruption is mainly used in the blood-head poison and contains, and macula is purple black, measles without adequate eruption, sore, eczema, diseases such as scald.The formulations of many in recent years relevant Asian puccoons are developed or transform and are used for treating for skin disease, as the finish of Asian puccoon, paste, film etc.; Also useful textiles is as carrier, and the plurality of Chinese that will the contain Asian puccoon cloth bag of packing into spreads on the affected part.These formulations are occupied critical role to treating for skin disease, but comprehensive in fact, the formulation that has or be not easy to large tracts of land and use continuously, or gas permeability is poor, skin is easily irritated, or influences attractive in appearancely, can not satisfy the needs of modern clinical treatment.If can add in the textiles of people's everyday general purpose or use and go with having the dermopathic Asian puccoon of control, medicine is slowly released in the process of daily wearing of people or use, act on the skin affected part, thereby reach the dermopathic purpose of control, just not only can avoid inconvenience that traditional methods of treatment brings to patient and painful, also comply with the development trend that present inner disease outer treat and treatment medical science turn to prevention and physical-fitness medicine.The applicant does not find the Chinese medicine Asian puccoon is combined with textile material to prevent and treat dermopathic document and patent at present, and this kind product still belongs to blank.
Summary of the invention
The purpose of this invention is to provide control dermopathic gromwell root medical polypropylene nitrile fiber, its preparation method and application thereof, make dissimilar textiless with the cloth that this fiber is made into, what can obtain not having the background technology shortcoming is used to prevent and treat dermopathic medicinal textiles.
The dermopathic gromwell root medical polypropylene nitrile of control of the present invention fiber, comprise polyacrylonitrile fibre, Asian puccoon and drug transdermal sorbefacient, Asian puccoon accounts for 0.0001%～30% of total weight of fibers, the drug transdermal sorbefacient accounts for 0.0001%～10% of total weight of fibers, and polyacrylonitrile fibre accounts for 1%～99% of total weight of fiber.
Described Asian puccoon is Asian puccoon medicinal powder, Radix Arnebiae extract medicinal extract, alkannin (shikonin), β, beta-dimethyl-acryloyl alkannin (β, β-dimethylacrylshikonin), Acetylshikonin (acetylshikonin), deoxyshikonin (deoxyshikonin), isobutyryl shikonin (isobutylshikonin) or its two or more mixture, wherein main component alkannin and derivatives chemical structure thereof in the Asian puccoon are as follows:
Described Radix Arnebiae extract medicinal extract is with the extract medicinal extract of variant solvent after to the Asian puccoon medicinal material extract, as ethanol extract medicinal extract, water extract medicinal extract, ligroin extraction medicinal extract, chloroform extract medicinal extract, acetone extract medicinal extract etc.
Described drug transdermal sorbefacient is borneol, azone, oleic acid, N-N-methyl-2-2-pyrrolidone N-or propylene glycol etc.
The dermopathic gromwell root medical polypropylene nitrile of control of the present invention fiber preparation method comprises the following steps:
(1) Asian puccoon and the adding of drug transdermal sorbefacient are contained in the spinning solution of polyacrylonitrile;
(2) spinning solution is made the dermopathic gromwell root medical polypropylene nitrile fiber of control through spinning technique.
The addition of described Asian puccoon is 0.0001～30% of a spinning solution weight;
The addition of described drug transdermal sorbefacient is 0.0001～10% of a spinning solution weight;
Described spinning technique is wet spinning technology, dry-spinning process, dry-jet wet spinning process or high-voltage electrostatic spinning technology.
The dermopathic gromwell root medical polypropylene nitrile of control of the present invention fiber can be applicable to the making of textiles lining and maybe this lining is made textiles.
The making of described textiles lining is the weaving process method that adopts conventional fabric panel, promptly requires to be made into cloth according to fabric index parameters such as the fabric structure of common face weave, Densities;
It is that manufacturing process according to common fabric carries out that described lining is made into textiles;
Described textiles is underwear, socks, handkerchief, bady's diaper etc., can be used for the control of itch, dermatitis, eczema, herpes zoster, beriberi and bady's diaper dermatitis.
Borneol, azone, oleic acid, N-N-methyl-2-2-pyrrolidone N-and propylene glycol all are transdermal penetrating agent commonly used among the present invention, can both increase the cuticular permeability of physiologic barrier, promote the medicine penetrate tissue by fast Absorption.The mechanism of action of azone is to have reduced the content of lipoid in the cuticula, and the structure and the iuntercellular lipid that change lipoids in the cuticula are arranged order, makes the mobile increase of film fat; The borneol effect is similar to azone, also can stimulate subcutaneous capillary permeability; The N-N-methyl-2-2-pyrrolidone N-distributes entering angle albumen by low concentration, influence cuticula lipid flowability, promotes medicine in cuticular distribution and increase cuticular moisture and reach and urge to ooze effect; Oleic acid then decomposes cuticula lipid membrane tight structure, forms lacuna between corneocyte, increases the epidermis permeability; And propylene glycol can make the keratin solvation, reduces the active force between medicine and tissue, normal and other penetrating agent use in conjunction.
Fiber of the present invention has the dermopathic effect of control, and the preparation method is simple, and the textiles made from this medicinal fibre not only has the function of common fabric but also has better prevention skin disease effect.
The specific embodiment
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment only to be used to the present invention is described and be not used in and limit the scope of the invention.Should be understood that in addition those skilled in the art can make various changes or modifications the present invention after the content of having read the present invention's instruction, these equivalent form of values fall within the application's appended claims institute restricted portion equally.
Embodiment 1
In the present embodiment, in the program of making spinning solution, make the spinning solution that contains polyacrylonitrile by existing technology earlier, wherein the polyacrylonitrile solution weight content is 1%; Add alkannin and drug transdermal sorbefacient borneol in the spinning solution then and stir, the addition of alkannin is 0.0001% of a spinning solution weight, and the addition of borneol is 0.0001% of a spinning solution weight; The spinning solution that then will contain alkannin and borneol adopts wet spinning technology to make fiber, has both contained polyacrylonitrile in the fiber of then making, and contains dermopathic Chinese medicine Asian puccoon of control and drug transdermal sorbefacient again; Be made into cloth with the fiber that makes according to the weaving process of existing lining, according to the weaving process of common fabric this cloth is made the textiles underwear again, then both contain polyacrylonitrile in the lining of underwear, contained dermopathic Asian puccoon of control and drug transdermal sorbefacient again.This underwear has functions such as the itch of control, dermatitis, eczema, herpes zoster.
Embodiment 2
In the present embodiment, the weight content of polyacrylonitrile solution is 99% in the spinning solution, the addition of alkannin is 0.1% of a spinning solution weight, the addition of drug transdermal sorbefacient azone is 0.1% of a spinning solution weight, in making the program of fiber, spinning solution is used in the method spinning technique, other method is identical with embodiment 1, can make the textiles socks, and these socks have the function of the beriberi of preventing and treating.
Embodiment 3
In the present embodiment, the weight content of polyacrylonitrile solution is 50% in the spinning solution, the addition of Asian puccoon ethanol extract medicinal extract is 10% of a spinning solution weight, the addition of drug transdermal sorbefacient oleic acid is 1.25% of a spinning solution weight, in making the program of fiber, spinning solution adopts dry-jet wet spinning process, other method is identical with embodiment 1, can make the textiles handkerchief, and this handkerchief has functions such as the itch of control, dermatitis, eczema, herpes zoster.
Embodiment 4
In the present embodiment, the weight content of polyacrylonitrile solution is 25% in the spinning solution, alkannin and Acetylshikonin (1: 1, w/w) addition is 20% of a spinning solution weight, the addition of drug transdermal sorbefacient N-N-methyl-2-2-pyrrolidone N-is 5% of a spinning solution weight, makes at spinning solution and adopts high-voltage electrostatic spinning technology in the program of fiber, and other method is identical with embodiment 1, can make bady's diaper, this diaper has the function of control bady's diaper dermatitis.
Embodiment 5
In the present embodiment, the weight content of polyacrylonitrile solution is 75% in the spinning solution, the addition of Asian puccoon water extract medicinal extract is 2.5% of a spinning solution weight, the addition of drug transdermal sorbefacient propylene glycol is 7.5% of a spinning solution weight, other method is identical with embodiment 1, can make to have the dermopathic gromwell root medical polypropylene fibre of control, lining, textiles.
Embodiment 6
In the present embodiment, the weight content of polyacrylonitrile solution is 13% in the spinning solution, the addition of Asian puccoon medicinal powder is 25% of a spinning solution weight, the addition of drug transdermal sorbefacient borneol is 9% of a spinning solution weight, other method is identical with embodiment 1, can make to have the dermopathic gromwell root medical polypropylene fibre of control, lining, textiles.
Embodiment 7
In the present embodiment, the weight content of polyacrylonitrile solution is 87% in the spinning solution, the addition of Asian puccoon acetone extract medicinal extract is 7.5% of a spinning solution weight, the addition of drug transdermal sorbefacient borneol is 0.001% of a spinning solution weight, other method is identical with embodiment 1, can make to have the dermopathic gromwell root medical polypropylene fibre of control, lining, textiles.
Embodiment 8
In the present embodiment, the weight content of polyacrylonitrile solution is 37.5% in the spinning solution, the addition of Asian puccoon medicinal powder is 17.5% of a spinning solution weight, the addition of drug transdermal sorbefacient oleic acid is 2.5% of a spinning solution weight, other method is identical with embodiment 1, can make to have the dermopathic gromwell root medical polypropylene fibre of control, lining, textiles.
Embodiment 9
In the present embodiment, the weight content of polyacrylonitrile solution is 67.5% in the spinning solution, β, beta-dimethyl-acryloyl alkannin, isobutyryl shikonin and alkannin (1: 1: 2, w/w/w) addition is 12.5% of a spinning solution weight, the addition of drug transdermal sorbefacient azone is 3.5% of a spinning solution weight, and other method is identical with embodiment 1, can make to have the dermopathic gromwell root medical polypropylene fibre of control, lining, textiles.
Embodiment 10
In the present embodiment, the weight content of polyacrylonitrile solution is 90% in the spinning solution, the addition of alkannin is 1.25% of a spinning solution weight, the addition of drug transdermal sorbefacient N-N-methyl-2-2-pyrrolidone N-is 4.25% of a spinning solution weight, other method is identical with embodiment 1, can make to have the dermopathic gromwell root medical polypropylene fibre of control, lining, textiles.
Embodiment 11
In the present embodiment, the weight content of polyacrylonitrile solution is 10% in the spinning solution, the addition of Asian puccoon medicinal powder is 22.5% of a spinning solution weight, the addition of drug transdermal sorbefacient azone is 8.75% of a spinning solution weight, other method is identical with embodiment 1, can make to have the dermopathic gromwell root medical polypropylene fibre of control, lining, textiles.
Claims (2)
1. the dermopathic gromwell root medical polypropylene nitrile fiber preparation method of control comprises the following steps:
(1) alkannin and the adding of drug transdermal sorbefacient azone are contained in the spinning solution of polyacrylonitrile, the addition of alkannin is 0.1% of a spinning solution weight, the addition of drug transdermal sorbefacient azone is 0.1% of a spinning solution weight, and polyacrylonitrile solution accounts for 99% of spinning solution weight;
Or Asian puccoon ethanol extract medicinal extract and drug transdermal sorbefacient oleic acid add and contain in the spinning solution of polyacrylonitrile, the addition of Asian puccoon ethanol extract medicinal extract is 10% of a spinning solution weight, the addition of drug transdermal sorbefacient oleic acid is 1.25% of a spinning solution weight, and polyacrylonitrile solution accounts for 50% of spinning solution weight;
Or 1: 1 alkannin of weight ratio and Acetylshikonin and drug transdermal sorbefacient N-N-methyl-2-2-pyrrolidone N-add and contain in the spinning solution of polyacrylonitrile, the addition of alkannin and Acetylshikonin is 20% of a spinning solution weight, the addition of drug transdermal sorbefacient N-N-methyl-2-2-pyrrolidone N-is 5% of a spinning solution weight, and polyacrylonitrile solution accounts for 25% of spinning solution weight;
Or Asian puccoon water extract medicinal extract and drug transdermal sorbefacient propylene glycol add and contain in the spinning solution of polyacrylonitrile, the addition of Asian puccoon water extract medicinal extract is 2.5% of a spinning solution weight, the addition of drug transdermal sorbefacient propylene glycol is 7.5% of a spinning solution weight, and polyacrylonitrile solution accounts for 75% of spinning solution weight;
Or Asian puccoon medicinal powder and drug transdermal sorbefacient borneol add and contain in the spinning solution of polyacrylonitrile, the addition of Asian puccoon medicinal powder is 25% of a spinning solution weight, the addition of drug transdermal sorbefacient borneol is 9% of a spinning solution weight, and polyacrylonitrile solution accounts for 13% of spinning solution weight;
Or Asian puccoon acetone extract medicinal extract and drug transdermal sorbefacient borneol add and contain in the spinning solution of polyacrylonitrile, the addition of Asian puccoon acetone extract medicinal extract is 7.5% of a spinning solution weight, the addition of drug transdermal sorbefacient borneol is 0.001% of a spinning solution weight, and polyacrylonitrile solution accounts for 87% of spinning solution weight;
Or Asian puccoon medicinal powder and drug transdermal sorbefacient oleic acid add and contain in the spinning solution of polyacrylonitrile, the addition of Asian puccoon medicinal powder is 17.5% of a spinning solution weight, the addition of drug transdermal sorbefacient oleic acid is 2.5% of a spinning solution weight, and polyacrylonitrile solution accounts for 37.5% of spinning solution weight;
Or 1: 1: 2 β of weight ratio, beta-dimethyl-acryloyl alkannin, isobutyryl shikonin and alkannin and drug transdermal sorbefacient azone add and contain in the spinning solution of polyacrylonitrile, β, the addition of beta-dimethyl-acryloyl alkannin, isobutyryl shikonin and alkannin is 12.5% of a spinning solution weight, the addition of drug transdermal sorbefacient azone is 3.5% of a spinning solution weight, and polyacrylonitrile solution accounts for 67.5% of spinning solution weight;
Or alkannin and drug transdermal sorbefacient N-N-methyl-2-2-pyrrolidone N-add and contain in the spinning solution of polyacrylonitrile, the addition of alkannin is 1.25% of a spinning solution weight, the addition of drug transdermal sorbefacient N-N-methyl-2-2-pyrrolidone N-is 4.25% of a spinning solution weight, and polyacrylonitrile solution accounts for 90% of spinning solution weight;
Or Asian puccoon medicinal powder and drug transdermal sorbefacient azone add and contain in the spinning solution of polyacrylonitrile, the addition of Asian puccoon medicinal powder is 22.5% of a spinning solution weight, the addition of drug transdermal sorbefacient azone is 8.75% of a spinning solution weight, and polyacrylonitrile solution accounts for 10% of spinning solution weight;
(2) spinning solution is made the dermopathic gromwell root medical polypropylene nitrile fiber of control through spinning technique.
2. the dermopathic gromwell root medical polypropylene nitrile of control according to claim 1 fiber preparation method is characterized in that:
Described spinning technique is wet spinning technology, dry-spinning process, dry-jet wet spinning process or high-voltage electrostatic spinning technology.
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| Application Number | Priority Date | Filing Date | Title |
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| CN200710047295A CN101148785B (en) | 2007-10-19 | 2007-10-19 | Gromwell root medical polypropylene fibre for preventing and curing skin disease, preparation method and application thereof |
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| CN200710047295A CN101148785B (en) | 2007-10-19 | 2007-10-19 | Gromwell root medical polypropylene fibre for preventing and curing skin disease, preparation method and application thereof |
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| CN101148785B true CN101148785B (en) | 2010-05-19 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20110051876A (en) * | 2009-11-11 | 2011-05-18 | 남종현 | Composition having a detoxification effect on smoking |
| CN102808287A (en) * | 2012-08-02 | 2012-12-05 | 上海理工大学 | Nanofiber membrane shaped borneol composite and preparation method thereof |
| CN106580794A (en) * | 2016-12-28 | 2017-04-26 | 芜湖凯奥尔环保科技有限公司 | Seaweed mask containing Chinese herbal medicinal ingredients and preparation method thereof |
| CN108691024A (en) * | 2018-06-29 | 2018-10-23 | 百事基材料（青岛）股份有限公司 | Modified acrylic fibres and preparation method thereof containing plant extracts |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030037243A (en) * | 2003-04-08 | 2003-05-12 | 이환업 | Fiber with biological material and its manufacturing method |
| CN100333766C (en) * | 2003-11-26 | 2007-08-29 | 胡祥仁 | Medicine for treating dermatopathy and its preparing process |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030037243A (en) * | 2003-04-08 | 2003-05-12 | 이환업 | Fiber with biological material and its manufacturing method |
| CN100333766C (en) * | 2003-11-26 | 2007-08-29 | 胡祥仁 | Medicine for treating dermatopathy and its preparing process |
Non-Patent Citations (4)
| Title |
|---|
| 贾晓光 熊元君 木拉提.紫草 2001年1月第1版.中国中医药出版社,2001,全文. |
| 贾晓光 熊元君 木拉提.紫草 2001年1月第1版.中国中医药出版社,2001,全文. * |
| 赵家祥.寻求中草药与纺织品的结合.中草药34 7.2003,34(7),附10-12. |
| 赵家祥.寻求中草药与纺织品的结合.中草药34 7.2003,34(7),附10-12. * |
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