CN103623104B - A kind ofly treat Chinese medicine patch of skin superficial position inflammation and preparation method thereof - Google Patents
A kind ofly treat Chinese medicine patch of skin superficial position inflammation and preparation method thereof Download PDFInfo
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- 239000003814 drug Substances 0.000 title claims abstract description 55
- 206010061218 Inflammation Diseases 0.000 title claims abstract description 24
- 230000004054 inflammatory process Effects 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 50
- 239000007788 liquid Substances 0.000 claims abstract description 49
- 229940079593 drug Drugs 0.000 claims abstract description 18
- 241000628997 Flos Species 0.000 claims abstract description 11
- 239000011505 plaster Substances 0.000 claims abstract description 11
- 210000000582 semen Anatomy 0.000 claims abstract description 11
- 238000007654 immersion Methods 0.000 claims description 16
- 239000000463 material Substances 0.000 claims description 8
- 239000002994 raw material Substances 0.000 claims description 7
- 238000005303 weighing Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 8
- 206010040880 Skin irritation Diseases 0.000 abstract description 2
- 229940126678 chinese medicines Drugs 0.000 abstract description 2
- 230000036556 skin irritation Effects 0.000 abstract description 2
- 231100000475 skin irritation Toxicity 0.000 abstract description 2
- 239000000203 mixture Substances 0.000 description 14
- 229930013930 alkaloid Natural products 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 150000003797 alkaloid derivatives Chemical class 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000002674 ointment Substances 0.000 description 3
- YDQWDHRMZQUTBA-UHFFFAOYSA-N Aloe emodin Chemical compound C1=CC=C2C(=O)C3=CC(CO)=CC(O)=C3C(=O)C2=C1O YDQWDHRMZQUTBA-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 201000000297 Erysipelas Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 241000191940 Staphylococcus Species 0.000 description 2
- 241000194017 Streptococcus Species 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- LQGUBLBATBMXHT-UHFFFAOYSA-N chrysophanol Chemical compound C1=CC=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O LQGUBLBATBMXHT-UHFFFAOYSA-N 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- QMGVPVSNSZLJIA-FVWCLLPLSA-N strychnine Chemical compound O([C@H]1CC(N([C@H]2[C@H]1[C@H]1C3)C=4C5=CC=CC=4)=O)CC=C1CN1[C@@H]3[C@]25CC1 QMGVPVSNSZLJIA-FVWCLLPLSA-N 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 241001480043 Arthrodermataceae Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- QMGVPVSNSZLJIA-UHFFFAOYSA-N Nux Vomica Natural products C1C2C3C4N(C=5C6=CC=CC=5)C(=O)CC3OCC=C2CN2C1C46CC2 QMGVPVSNSZLJIA-UHFFFAOYSA-N 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- RBBVPNQTBKHOEQ-KKSFZXQISA-O Phellodendrine Chemical compound C1CC2=CC(OC)=C(O)C=C2[C@H]2[N@+]1(C)CC(C=C(C(=C1)O)OC)=C1C2 RBBVPNQTBKHOEQ-KKSFZXQISA-O 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 241001279009 Strychnos toxifera Species 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 229920001617 Vinyon Polymers 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 description 1
- 150000004056 anthraquinones Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 description 1
- 229940093265 berberine Drugs 0.000 description 1
- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000037304 dermatophytes Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 230000003119 painkilling effect Effects 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 208000001297 phlebitis Diseases 0.000 description 1
- KINGXFAMZNIVNL-SXQDSXCISA-N safflor yellow A Natural products OC[C@@H]1O[C@H]2[C@H](OC3=C2C(=O)C(=C(O)C=Cc4ccc(O)cc4)C(=O)[C@]3(O)[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@@H](O)[C@H]1O KINGXFAMZNIVNL-SXQDSXCISA-N 0.000 description 1
- 210000001044 sensory neuron Anatomy 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 229960005453 strychnine Drugs 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
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Abstract
The invention belongs to the field of Chinese medicines, be specifically related to a kind ofly treat Chinese medicine patch of skin superficial position inflammation and preparation method thereof.The Chinese medicine patch of this treatment skin superficial position inflammation is by Semen Strychni, Rhizoma Coptidis, Radix Sophorae Flavescentis, Cortex Phellodendri, the Radix Angelicae Dahuricae, Radix Et Rhizoma Rhei, Flos Carthami, proportionally after mix homogeneously, is repeatedly fully soaked in ethanol and obtains corresponding medicinal liquid, then by injecting liquid drug on plaster.The present invention adopts pure Chinese medicinal preparation, and formula is simple, and determined curative effect, skin irritation is little.Medicinal liquid is made Chinese medicine patch, can be pasted on skin, patient can be freely movable; Inner face is medicinal liquid, can continue soak, uninterruptedly treat; Outside is non-leakage, prevents medicinal liquid from exosmosing, is infected with medicated clothing; Chinese medicine patch can make all size size, applied widely, convenient, attractive in appearance.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind ofly treat Chinese medicine patch of skin superficial position inflammation and preparation method thereof.
Background technology
Skin superficial inflammation is many because malignant bacteria is by the tiny breakage intrusion of skin surface, and causing skin to occur red, swollen, hot, pain symptom, is a kind of very common inflammation, such as superficial phlebitis, erysipelas, skin superficial infection etc.
Current clinical treatment mostly is application medicinal liquid, ointment is coated in inflammation surface, though there is certain curative effect, but still there is following shortcoming: 1, the formula of medicinal liquid or ointment employing is more complicated, and processing technology is loaded down with trivial details, and need add more adjuvant, curative effect is slower; 2, medicinal liquid or ointment are coated in skin surface and can volatilize very soon, are difficult to continued treatment; 3, external used medicine easily pollutes bedding, medicated clothing, uses very inconvenience; 4, during application, patient must brake, exposes in affected part, affects patient activity.
Summary of the invention
For the problems referred to above, the present invention proposes and a kind ofly treat Chinese medicine patch of skin superficial position inflammation and preparation method thereof.This Chinese medicine patch heat-clearing and toxic substances removing, activating blood and eliminatng dampness, has fabulous curative effect to skin superficial position inflammation, and uses convenient.
According to inventor's clinical experience for many years, the Chinese medicine patch of this treatment skin superficial position inflammation, according to parts by weight, is made up of following raw material medicaments: Semen Strychni 25-35 gram, Rhizoma Coptidis 25-35 gram, Radix Sophorae Flavescentis 25-35 gram, Cortex Phellodendri 10-20 gram, Radix Angelicae Dahuricae 10-15 gram, Radix Et Rhizoma Rhei 25-35 gram, Flos Carthami 25-35 gram.
Semen Strychni mass dissipating and swelling eliminating in side, removing obstruction in the collateral to relieve pain.The multiple alkaloid such as the strychnine in Semen Strychni, has paralysis effect to sensory nerve ending, has inhibitory action to dermatophytes.
Rhizoma Coptidis heat clearing and damp drying, eliminating fire and detoxication, wherein containing multiple alkaloid, has very wide antibacterial range, as staphylococcus, bacillus pyocyaneus, Hemolytic streptococcus etc.
Radix Sophorae Flavescentis heat clearing and damp drying, parasite killing diuresis.Containing multiple alkaloids such as matrines in Radix Sophorae Flavescentis, there is inhibitory action to various skin fungus.
Cortex Phellodendri heat clearing and damp drying, eliminating fire and detoxication, bring down a fever except steaming, wherein containing the multiple alkaloid such as berberine, phellodendrine, antimicrobial spectrum is similar with Rhizoma Coptidis, and external can impel the absorption of subcutaneous oozing of blood.
The Radix Angelicae Dahuricae induces sweat loose wind, sensible, pain relieving, dampness leukorrhagia stopping, detumescence and apocenosis, wherein containing Radix Angelicae Dahuricae element, Radix Angelicae Dahuricae ether etc., has inhibitory action to pathomycetes such as microspore's tinea bacterium.
Radix Et Rhizoma Rhei heat and toxic materials clearing away, clearing away heat-fire, hemostasis, removing toxic substances, blood circulation promoting and blood stasis dispelling, wherein containing anthraquinone derivative, as chrysophanic acid, aloe-emodin etc., all have inhibitory action to multiple Grain-positive and negative bacteria, and the most responsive is staphylococcus and streptococcus.
Flos Carthami promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing, wherein containing safflower yellow, Flos Carthami wet goods, can pain relieving, promote that blood stasis absorbs.
Various crude drug in side combinationally use, and make each medicine produce synergism, thus effectively can treat skin superficial position inflammation.
The preparation method of Chinese medicine patch of the present invention is as follows: by each component material medicine according to aforementioned proportion mix homogeneously, is soaked in 1500-2000ml ethanol together, soaks 70-72 hour, is leached by medicinal liquid; Again by drug immersion in 1500-2000ml ethanol, leach medicinal liquid after 70-72 hour; Drug immersion in 1500-2000ml ethanol, is leached medicinal liquid after 70-72 hour by third time; By above-mentioned three part medicinal liquid mix homogeneously, by 0.5-1ml/cm
2consumption to be expelled on plaster standby treatment and to use.
Studying for a long period of time and manufacturing experimently through inventor, has finally found Semen Strychni 30 grams, Rhizoma Coptidis 30 grams, Radix Sophorae Flavescentis 30 grams, Cortex Phellodendri 15 grams, the Radix Angelicae Dahuricae 12 grams, Radix Et Rhizoma Rhei 30 grams, after Flos Carthami 30 grams of mix homogeneously, be soaked in 2000ml ethanol together, soak 72 hours, medicinal liquid is leached; Again by drug immersion in 2000ml ethanol, leach medicinal liquid after 72 hours; Drug immersion in 2000ml ethanol, is leached medicinal liquid after 72 hours by third time; By above-mentioned three part medicinal liquid mix homogeneously, by 0.5-1ml/cm
2consumption to be expelled on plaster standby treatment and to use.
The plaster that the present invention adopts is three-decker altogether, and internal layer is non-woven fabrics, and middle level is the sterile absorbent absorbent cotton containing medicinal liquid of the present invention, and skin is the vinyon of antiseep; Its surrounding be have an one fixed width paste district.Through clinical test of many times, the injection consumption of medicinal liquid is 0.5-1ml/cm
2, within the scope of this, consumption can meet clinical practice, and anti-inflammation liquid can not be caused again to leak outside.The injection consumption of medicinal liquid is less than 0.5ml/cm
2time, cause clinical efficacy to decline; The injection consumption of medicinal liquid is greater than 1ml/cm
2time, easily cause anti-inflammation liquid to leak outside.
During use, by doctor according to skin superficial inflammation scope, select the plaster of appropriate size, be pasted on scytitis surface, within every 6 hours, change once, apply and just have obvious curative effects in 1-2 days, obviously can alleviate redness, the pain in affected part, continue application and can fully recover for 7-10 days.
In sum, the present invention adopts pure Chinese medicinal preparation, and formula is simple, and determined curative effect, skin irritation is little.Medicinal liquid is made Chinese medicine patch, can be pasted on skin, patient can be freely movable; Inner face is medicinal liquid, can continue soak, uninterruptedly treat; Outside is non-leakage, ensures that drug effect continues, and prevents medicinal liquid from exosmosing, be infected with medicated clothing; This Chinese medicine patch can make all size size, applied widely, convenient, attractive in appearance.
Detailed description of the invention
Embodiment 1
Treat a Chinese medicine patch for skin superficial position inflammation, according to parts by weight, be made up of following raw material medicaments: Semen Strychni 30 grams, Rhizoma Coptidis 30 grams, Radix Sophorae Flavescentis 30 grams, Cortex Phellodendri 15 grams, the Radix Angelicae Dahuricae 12 grams, Radix Et Rhizoma Rhei 30 grams, 30 grams, Flos Carthami;
Its preparation method is as follows: by each component material medicine according to aforementioned proportion mix homogeneously, is soaked in 2000ml ethanol together, soaks 72 hours, is leached by medicinal liquid; Again by drug immersion in 2000ml ethanol, leach medicinal liquid after 72 hours; Drug immersion in 2000ml ethanol, is leached medicinal liquid after 72 hours by third time;
By above-mentioned three part medicinal liquid mix homogeneously, by 1ml/cm
2consumption to be expelled on plaster standby treatment and to use.
Embodiment 2
Treat a Chinese medicine patch for skin superficial position inflammation, according to parts by weight, be made up of following raw material medicaments: Semen Strychni 25 grams, Rhizoma Coptidis 35 grams, Radix Sophorae Flavescentis 32 grams, Cortex Phellodendri 10 grams, the Radix Angelicae Dahuricae 11 grams, Radix Et Rhizoma Rhei 28 grams, 35 grams, Flos Carthami;
Its preparation method is as follows: by each component material medicine according to aforementioned proportion mix homogeneously, is soaked in 1500ml ethanol together, soaks 70 hours, is leached by medicinal liquid; Again by drug immersion in 1500ml ethanol, leach medicinal liquid after 70 hours; Drug immersion in 1500ml ethanol, is leached medicinal liquid after 70 hours by third time;
By above-mentioned three part medicinal liquid mix homogeneously, by 0.5ml/cm
2consumption to be expelled on plaster standby treatment and to use.
Embodiment 3
Treat a Chinese medicine patch for skin superficial position inflammation, according to parts by weight, be made up of following raw material medicaments: Semen Strychni 35 grams, Rhizoma Coptidis 25 grams, Radix Sophorae Flavescentis 27 grams, Cortex Phellodendri 12 grams, the Radix Angelicae Dahuricae 10 grams, Radix Et Rhizoma Rhei 33 grams, 25 grams, Flos Carthami;
Its preparation method is as follows: by each component material medicine according to aforementioned proportion mix homogeneously, is soaked in 1600ml ethanol together, soaks 72 hours, is leached by medicinal liquid; Again by drug immersion in 1600ml ethanol, leach medicinal liquid after 72 hours; Drug immersion in 1600ml ethanol, is leached medicinal liquid after 72 hours by third time;
By above-mentioned three part medicinal liquid mix homogeneously, by 0.6ml/cm
2consumption to be expelled on plaster standby treatment and to use.
Embodiment 4
Treat a Chinese medicine patch for skin superficial position inflammation, according to parts by weight, be made up of following raw material medicaments: Semen Strychni 27 grams, Rhizoma Coptidis 27 grams, Radix Sophorae Flavescentis 35 grams, Cortex Phellodendri 17 grams, the Radix Angelicae Dahuricae 15 grams, Radix Et Rhizoma Rhei 35 grams, 26 grams, Flos Carthami;
Its preparation method is as follows: by each component material medicine according to aforementioned proportion mix homogeneously, is soaked in 1700ml ethanol together, soaks 71 hours, is leached by medicinal liquid; Again by drug immersion in 1700ml ethanol, leach medicinal liquid after 71 hours; Drug immersion in 1700ml ethanol, is leached medicinal liquid after 71 hours by third time;
By above-mentioned three part medicinal liquid mix homogeneously, by 0.7ml/cm
2consumption to be expelled on plaster standby treatment and to use.
Embodiment 5
Treat a Chinese medicine patch for skin superficial position inflammation, according to parts by weight, be made up of following raw material medicaments: Semen Strychni 32 grams, Rhizoma Coptidis 32 grams, Radix Sophorae Flavescentis 25 grams, Cortex Phellodendri 20 grams, the Radix Angelicae Dahuricae 13 grams, Radix Et Rhizoma Rhei 25 grams, 34 grams, Flos Carthami;
Its preparation method is as follows: by each component material medicine according to aforementioned proportion mix homogeneously, is soaked in 1600ml ethanol together, soaks 70 hours, is leached by medicinal liquid; Again by drug immersion in 1600ml ethanol, leach medicinal liquid after 70 hours; Drug immersion in 1600ml ethanol, is leached medicinal liquid after 70 hours by third time;
By above-mentioned three part medicinal liquid mix homogeneously, by 0.8ml/cm
2consumption to be expelled on plaster standby treatment and to use.
Experimental example 1
Patient Wang, man, 44 years old, right leg red and swollen heat pain companion body generates heat 3 days, is diagnosed as erysipelas, provides through inventor, use the Chinese medicine patch of the treatment skin superficial position inflammation obtained according to proportioning described in the embodiment of the present invention 1 and method, within every 6 hours, change once, continuous external 10 days, and lie up by doctor's advice, lifting affected limb, patient's right leg red and swollen heat pain and fever of the body transference cure, patient reacts good, has no side effect.
Experimental example 2
Patient Xiao, female, 71 years old, right leg scytitis 5 days, there is provided through inventor, use the Chinese medicine patch of the treatment skin superficial position inflammation obtained according to proportioning described in the embodiment of the present invention 3 and method, within every 6 hours, change once, continuous external 7 days, and lie up by doctor's advice, lifting affected limb, patient's right leg inflammation disappears, patient reacts good, has no side effect.
Adopt above method, treat patient 64 example altogether, wherein man 36 example, female 28 example, effective 60 examples, effective 4 examples, obvious effective rate is 93.75%, and effective percentage is 6.25%, total effective rate 100%.
Claims (1)
1. treat a Chinese medicine patch for skin superficial position inflammation, it is characterized in that: according to weighing scale, be made up of following raw material medicaments: Semen Strychni 30 grams, Rhizoma Coptidis 30 grams, Radix Sophorae Flavescentis 30 grams, Cortex Phellodendri 15 grams, the Radix Angelicae Dahuricae 12 grams, Radix Et Rhizoma Rhei 30 grams, 30 grams, Flos Carthami;
Its preparation method is: by each material medicine according to above-mentioned weight mix homogeneously, is soaked in 2000ml ethanol together, soaks 72 hours, is leached by medicinal liquid; Again by drug immersion in 2000ml ethanol, leach medicinal liquid after 72 hours; Drug immersion in 2000ml ethanol, is leached medicinal liquid after 72 hours by third time;
By above-mentioned three part medicinal liquid mix homogeneously, by 0.5-1ml/cm
2consumption to be expelled on plaster standby treatment and to use.
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| CN201310596085.XA CN103623104B (en) | 2013-11-22 | 2013-11-22 | A kind ofly treat Chinese medicine patch of skin superficial position inflammation and preparation method thereof |
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| CN105596531A (en) * | 2016-01-30 | 2016-05-25 | 朱玉水 | Externally-applied plaster for treating gynecologic inflammation and preparation method thereof |
| CN107582857A (en) * | 2017-10-16 | 2018-01-16 | 陈世标 | A kind of decoction for treating toxin expelling healing and preparation method thereof |
| CN109512944A (en) * | 2019-01-21 | 2019-03-26 | 重庆市中医院 | A kind of pair of yellow detoxification tincture and preparation method thereof |
| CN110613804B (en) * | 2019-10-11 | 2023-09-22 | 河南大农联生物工程有限公司 | Traditional Chinese medicine composition for treating canine and feline otitis externa and preparation method thereof |
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| CN1090184A (en) * | 1993-01-20 | 1994-08-03 | 陈煜超 | A kind of Chinese medicine for outer use for the treatment of dermatitis and eczema |
| CN101480445A (en) * | 2008-01-07 | 2009-07-15 | 北京科技桥科贸有限公司 | Medicine for treating dermatitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1176724C (en) * | 1999-07-13 | 2004-11-24 | 安得勋 | Herb medicine composition to be contained in sanitary materials for infants |
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|---|---|---|---|---|
| CN1090184A (en) * | 1993-01-20 | 1994-08-03 | 陈煜超 | A kind of Chinese medicine for outer use for the treatment of dermatitis and eczema |
| CN101480445A (en) * | 2008-01-07 | 2009-07-15 | 北京科技桥科贸有限公司 | Medicine for treating dermatitis |
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Application publication date: 20140312 Assignee: Shandong Desheng Cell Therapy Engineering Technology Co.,Ltd. Assignor: Shandong Provincial Hospital Affiliated to Shandong First Medical University Contract record no.: X2023980053623 Denomination of invention: A traditional Chinese medicine patch for treating superficial skin inflammation and its preparation method Granted publication date: 20151111 License type: Exclusive License Record date: 20231226 |
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