CN1954213A - 用于产生细胞群体的蛋白表达谱的分析平台和方法 - Google Patents

用于产生细胞群体的蛋白表达谱的分析平台和方法 Download PDF

Info

Publication number
CN1954213A
CN1954213A CNA2004800422474A CN200480042247A CN1954213A CN 1954213 A CN1954213 A CN 1954213A CN A2004800422474 A CNA2004800422474 A CN A2004800422474A CN 200480042247 A CN200480042247 A CN 200480042247A CN 1954213 A CN1954213 A CN 1954213A
Authority
CN
China
Prior art keywords
solid support
different
lysate
proteins
layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2004800422474A
Other languages
English (en)
Chinese (zh)
Inventor
M·帕夫拉克
E·施克
P·奥罗什兰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of CN1954213A publication Critical patent/CN1954213A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G01N33/567—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds utilising isolate of tissue or organ as binding agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
CNA2004800422474A 2004-03-03 2004-03-03 用于产生细胞群体的蛋白表达谱的分析平台和方法 Pending CN1954213A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2004/002127 WO2005095965A1 (en) 2004-03-03 2004-03-03 Analytical platform and method for generating protein expression profiles of cell populations

Publications (1)

Publication Number Publication Date
CN1954213A true CN1954213A (zh) 2007-04-25

Family

ID=34957113

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800422474A Pending CN1954213A (zh) 2004-03-03 2004-03-03 用于产生细胞群体的蛋白表达谱的分析平台和方法

Country Status (7)

Country Link
US (1) US20080020409A1 (enExample)
EP (1) EP1730530A1 (enExample)
JP (1) JP2007526460A (enExample)
CN (1) CN1954213A (enExample)
AU (1) AU2004318038A1 (enExample)
CA (1) CA2559803A1 (enExample)
WO (1) WO2005095965A1 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107209114A (zh) * 2015-02-05 2017-09-26 日东电工株式会社 测量装置
CN109459562A (zh) * 2017-09-06 2019-03-12 阿姆普勒斯生物科学公司 用于提高生物测定动态范围的方法
CN109477084A (zh) * 2016-07-19 2019-03-15 国立研究开发法人农业·食品产业技术综合研究机构 使用等离子体在植物细胞内导入物质的方法
CN110609078A (zh) * 2019-09-20 2019-12-24 南京谱利健生物技术有限公司 一种检测蛋白磷酸化和乙酰氨基葡萄糖化关联作用的方法
CN113970644A (zh) * 2021-12-24 2022-01-25 天德瑞(北京)生物科技有限公司 基于hrp标记蛋白的工作浓度检测方法

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011008990A1 (en) 2009-07-15 2011-01-20 Prometheus Laboratories Inc. Drug selection for gastric cancer therapy using antibody-based arrays
WO2008036802A2 (en) * 2006-09-21 2008-03-27 Prometheus Laboratories Inc. Antibody-based arrays for detecting multiple signal transducers in rare circulating cells
BRPI0717416A2 (pt) 2006-09-21 2013-11-12 Prometheus Lab Inc Método para realizar um imunoensaio complexo de alta produtividade, e, arranjo
BRPI0813583A2 (pt) 2007-07-13 2014-12-30 Prometheus Lab Inc Métodos para selecionar um medicamento anticâncer, para identificar a resposta de um tumor pulmonar, e para prognosticar a resposta de um paciente, e, arranjo
CN103399144B (zh) 2008-02-25 2015-10-28 雀巢产品技术援助有限公司 用抗体阵列选择乳腺癌治疗药物
EP2408372B1 (en) 2009-03-02 2019-01-09 Seventh Sense Biosystems, Inc. Devices associated with blood sampling
US9295417B2 (en) 2011-04-29 2016-03-29 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
US20130158482A1 (en) 2010-07-26 2013-06-20 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
US20120039809A1 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
WO2012046412A1 (ja) * 2010-10-07 2012-04-12 パナソニック株式会社 プラズモンセンサ
ES2565805T3 (es) 2010-11-09 2016-04-07 Seventh Sense Biosystems, Inc. Sistemas e interfaces para el muestreo de sangre
US9719995B2 (en) 2011-02-03 2017-08-01 Pierian Holdings, Inc. Drug selection for colorectal cancer therapy using receptor tyrosine kinase profiling
AU2012249683A1 (en) 2011-04-29 2013-11-14 Seventh Sense Biosystems, Inc. Devices and methods for collection and/or manipulation of blood spots or other bodily fluids
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
KR102237667B1 (ko) 2011-04-29 2021-04-12 세븐쓰 센스 바이오시스템즈, 인크. 유체들의 전달 및/또는 수용
WO2013033623A1 (en) 2011-09-02 2013-03-07 Nestec S.A. Profiling of signal pathway proteins to determine therapeutic efficacy
EP2573565A1 (en) 2011-09-23 2013-03-27 Gerhard Matthias Kresbach Immune detection method for common epitopes of two or more analytes in samples of complex compositions, device, and kit for enabling said immune detection method
EP3892997A1 (en) * 2013-01-10 2021-10-13 Emory University Systems, methods and computer readable storage media for analyzing a sample
KR101527797B1 (ko) * 2014-06-03 2015-06-15 한국과학기술원 신호전달경로의 활성화 상태 분석방법 및 이를 이용한 개인 맞춤형 치료제의 선정방법
US10520514B2 (en) * 2017-02-01 2019-12-31 Korea Institute Of Science And Technology Method for monitoring post-translational modification of protein
KR102342302B1 (ko) * 2018-09-28 2021-12-24 주식회사 스몰머신즈 정량 분석용 단백질 칩
CN114112305B (zh) * 2021-12-06 2024-02-06 西南石油大学 一种内外流夹击的柔性立管流固耦合效应测试装置及方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL317379A1 (en) * 1994-05-27 1997-04-01 Ciba Geigy Ag Supercritically excited luminescence detecting process
EP1890130A3 (en) * 1995-05-12 2008-02-27 Novartis AG Sensor platform for the parallel detection of a plurality of analytes using evanescently excited luminescenes
DE19628928A1 (de) * 1996-07-18 1998-01-22 Basf Ag Feste Träger für analytische Meßverfahren, ein Verfahren zu ihrer Herstellung sowie ihre Verwendung
WO1998009156A1 (en) * 1996-08-29 1998-03-05 Novartis Ag Optical chemical / biochemical sensor
US6087102A (en) * 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
AU735887B2 (en) * 1998-01-09 2001-07-19 Phylogica Limited Peptide detection method
US6197599B1 (en) * 1998-07-30 2001-03-06 Guorong Chin Method to detect proteins
EP1112262B1 (en) * 1998-09-09 2004-08-04 Inflazyme Pharmaceuticals Ltd. Substituted gamma-phenyl-delta-lactones and analogs thereof and uses related thereto
US20030027214A1 (en) * 1999-02-17 2003-02-06 Kamb Carl Alexander Methods for substrate-ligand interaction screening
US6972198B2 (en) * 1999-02-26 2005-12-06 Cyclacel, Ltd. Methods and compositions using protein binding partners
GB0007088D0 (en) * 2000-03-23 2000-05-17 Torsana A S Detection of immunological memory determining the position of loci of pathologyand therapeutic t-cell conjugates
US7175811B2 (en) * 2000-04-28 2007-02-13 Edgelight Biosciences Micro-array evanescent wave fluorescence detection device
EP1287360A2 (de) * 2000-06-02 2003-03-05 Zeptosens AG Kit und verfahren zur multianalytbestimmung
EP1315968B1 (de) * 2000-09-05 2008-02-13 Bayer Technology Services GmbH Verfahren zur abscheidung von mono- und mehrfachschichten von organophosphor- und -phosphonsäuren und deren salzen sowie deren verwendung
WO2002023199A2 (en) * 2000-09-14 2002-03-21 Reverse Proteomics Research Institute Co., Ltd. Method, system, apparatus and device for discovering and preparing chemical compounds
US7070740B1 (en) * 2000-09-28 2006-07-04 Beckman Coulter, Inc. Method and apparatus for processing biomolecule arrays
US7332286B2 (en) * 2001-02-02 2008-02-19 University Of Pennsylvania Peptide or protein microassay method and apparatus
US7465568B2 (en) * 2002-04-26 2008-12-16 Bristol-Myers Squibb Company Essential fungal polynucleotides, polypeptides, and methods of use
US20060172344A1 (en) * 2002-07-18 2006-08-03 Yaeta Endo Single chain antibody and use thereof
ATE520027T1 (de) * 2002-09-03 2011-08-15 Bayer Technology Services Gmbh Analytische plattform und nachweisverfahren mit gegebenenfalls nach fraktionierung in einer probe nachzuweisenden analyten als immobilisierten spezifischen bindungspartnern
US6956651B2 (en) * 2002-09-07 2005-10-18 Hilary S. Lackritz Bioanalysis systems including optical integrated circuit

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107209114A (zh) * 2015-02-05 2017-09-26 日东电工株式会社 测量装置
CN109477084A (zh) * 2016-07-19 2019-03-15 国立研究开发法人农业·食品产业技术综合研究机构 使用等离子体在植物细胞内导入物质的方法
CN109459562A (zh) * 2017-09-06 2019-03-12 阿姆普勒斯生物科学公司 用于提高生物测定动态范围的方法
CN110609078A (zh) * 2019-09-20 2019-12-24 南京谱利健生物技术有限公司 一种检测蛋白磷酸化和乙酰氨基葡萄糖化关联作用的方法
CN113970644A (zh) * 2021-12-24 2022-01-25 天德瑞(北京)生物科技有限公司 基于hrp标记蛋白的工作浓度检测方法
CN113970644B (zh) * 2021-12-24 2022-05-27 天德瑞(北京)生物科技有限公司 基于hrp标记蛋白的工作浓度检测方法

Also Published As

Publication number Publication date
EP1730530A1 (en) 2006-12-13
AU2004318038A1 (en) 2005-10-13
US20080020409A1 (en) 2008-01-24
JP2007526460A (ja) 2007-09-13
WO2005095965A1 (en) 2005-10-13
CA2559803A1 (en) 2005-10-13

Similar Documents

Publication Publication Date Title
CN1954213A (zh) 用于产生细胞群体的蛋白表达谱的分析平台和方法
AU2013207599B2 (en) Process for determining one or more analytes in samples of biological origin having complex composition, and use thereof
EP1556695B1 (de) Analytische plattform und nachweisverfahren mit gegebenenfalls nach fraktionierung in einer probe nachzuweisenden analyten als immobilisierten spezifischen bindungspartnern
US7645612B2 (en) Kit and method for multi-analyte determination
US20210325334A1 (en) Devices and Methods for Sample Analysis
JP5860922B2 (ja) ビーズまたは他の捕捉物を用いた分子または粒子の超高感度検出
JP2007526460A5 (enExample)
WO2001013096A1 (de) Vorrichtung und verfahren zur multianalytbestimmung
WO2002040998A2 (de) Kit und verfahren zur multianalytbestimmung
JP2005537486A (ja) 分析対象物が試料中で固定化された特異的結合パートナーとして測定される分析プラットフォーム及び検出法
WO2003096018A2 (de) Kit zur assay-entwicklung und für serien-analysen
WO2002046756A1 (de) Kit und verfahren zur multianalytbestimmung, mit vorkehrungen zur ortsaufgelösten referenzierung einer anregungslichtintensitaet
EP1512012B1 (en) Biomolecular kinetics method using a flow-through microarray
Zhou et al. Label-free optical imaging of nanoscale single entities
Soini et al. Two-photon fluorescence excitation in detection of biomolecules
Martin et al. Real-time sensing of single-ligand delivery with nanoaperture-integrated microfluidic devices
ES2369494T3 (es) Plataforma analítica y procedimiento de detección con analitos a detectar en una muestra eventualmente después del fraccionamiento como asociados de unión específicos inmovilizados.
Rodriguez The development of microbead-based immunoassays: An application of the “electronic taste chip”

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Open date: 20070425