CN1943757B - A Chinese traditional medicinal composition for treatment of hemicrania and its preparation method - Google Patents
A Chinese traditional medicinal composition for treatment of hemicrania and its preparation method Download PDFInfo
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- CN1943757B CN1943757B CN2005101059569A CN200510105956A CN1943757B CN 1943757 B CN1943757 B CN 1943757B CN 2005101059569 A CN2005101059569 A CN 2005101059569A CN 200510105956 A CN200510105956 A CN 200510105956A CN 1943757 B CN1943757 B CN 1943757B
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Abstract
The invention discloses a Chinese traditional medicine composition used in treatment of hemicrania, belongs to the field of Chinese traditional medicine. The combination is prepared with a certain proportion of rhizoma chuanxiong, radix curcumae, rhizoma gastrodiae, radix et rhizoma salviae miltiorrhizae, etc. by certain specific technology, used in the treatment of hemicrania of liver wind stagnation with significant effect. The invention discloses the preparation method of the Chinese traditional medicine composition in addition.
Description
Technical field
The present invention relates to a kind of migrainous Chinese medicine composition and preparation method thereof that is used for the treatment of, belong to the field of Chinese medicines.
Background technology
Migraine is a kind of commonly encountered diseases, multiple Neurology Department disease, be that a kind of discontinuity is shown effect repeatedly, based on the pulsatile headache disease of side headache, often with symptoms such as vision, sensation, motion, emotion and gastrointestinal autonomic nervous dysfunctions.
According to report from the U.S., be subjected to the U.S. adult that migraine influences to be about 2,800 ten thousand, wherein be mainly 25～55 years old, the be in ability to work adult in strong period.Annual have 6% male and 18% women once above migraine to occur approximately, disability during patient's migraine more than 82% of women 85% and male wherein, 1/3 needs of patients is lain up, and the economic loss that therefore cause the whole year can be up to 13,000,000,000 dollars.Meanwhile, although migrainous sickness rate is very high, even still have the patient above 50% to fail to obtain correct diagnosis and effectively treatment in the U.S., reason is that these patients think that the doctor is also powerless to migraine at present.This and migraine pathogeny complexity still do not have consensus at present, and it are relevant to lack reliable aided diagnosis method.
At present the migrainous cause of disease is still lacked deep research, theoretic discussion few in number also just centers on convention in argument in a circle, lack clear and definite conclusion and innovation opinion, these are all restricting drug research, cause migraine drug effect research index often to lack specificity and specificity, can not provide strong directive function for clinical.And the traditional Chinese medical science is at this present situation, the hypothesis of migrainous pathogenesis for " nerve-blood vessel-blood " system disorders proposed, and play therapeutical effect by a plurality of target spots that the Chinese medicine number of ways acts on these system's many levels, demonstrated the migrainous distinctive feature of Chinese medicine.
The objective of the invention is migrainous Chinese patent medicine, thereby reach mitigate the disease, improve the purpose of curative effect for the treatment liver-wind folder blood stasis syndrome that a kind of determined curative effect is provided.
Summary of the invention
One of purpose of the present invention provides a kind of hypertensive Chinese medicine composition that is used for the treatment of;
Two of purpose of the present invention provides the preparation method of this Chinese medicine composition.
The present invention seeks to be achieved through the following technical solutions:
Medicine of the present invention is made by following bulk drugs: Rhizoma Chuanxiong 60～180 weight portions; Radix Salviae Miltiorrhizae 50～150 weight portions; Radix Curcumae 50～150 weight portions, Rhizoma Typhonii (system) 25～75 weight portions, artificial Calculus Bovis's 15～45 weight portions; Rhizoma Gastrodiae 50～150 weight portions; the Radix Paeoniae Alba 50～150 weight portions, Flos Chrysanthemi 25～75 weight portions, the Radix Angelicae Dahuricae 50～150 weight portions; Herba Asari 10～30 weight portions, Borneolum Syntheticum 1～5 weight portion.
Medicine optimum weight part proportioning of the present invention is: Rhizoma Chuanxiong 120 weight portions; Radix Salviae Miltiorrhizae 100 weight portions; Radix Curcumae 100 weight portions, Rhizoma Typhonii (system) 50 weight portions, artificial Calculus Bovis's 30 weight portions; Rhizoma Gastrodiae 100 weight portions; the Radix Paeoniae Alba 100 weight portions, Flos Chrysanthemi 50 weight portions, the Radix Angelicae Dahuricae 100 weight portions; Herba Asari 20 weight portions, Borneolum Syntheticum 3 weight portions.
Above crude drug can be made multiple oral formulations, comprises pharmaceutical dosage forms such as capsule, granule, tablet, pill.
The common preparation process of these preparations is: above ten simply, gets the Radix Angelicae Dahuricae and the 1/3 amount Radix Paeoniae Alba, mixes, and is ground into fine powder; Herba Asari is in addition cataclasm, and vapor distillation is collected volatile oil (medicinal residues, medicinal liquid keep standby), and volatile oil adds beta-schardinger dextrin-and makes clathrate; Borneolum Syntheticum adds beta-schardinger dextrin-and makes clathrate; Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae add 70% alcohol heating reflux 2～4 times, filter, and merging filtrate reclaims ethanol, and concentrated solution and last medicinal residues keep standby respectively; The Radix Paeoniae Alba of Radix Curcumae, Rhizoma Gastrodiae, Flos Chrysanthemi, Rhizoma Typhonii (system) and 2/3 amount, medicinal residues, medicinal liquid merging with Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Herba Asari decoct with water 2～4 times; filter; merging filtrate, concentrating under reduced pressure merges with above-mentioned alcohol extraction concentrated solution; continue to be concentrated into the clear paste that relative density is 1.30～1.35 (70 ℃); add the Radix Angelicae Dahuricae and 1/3 amount Radix Paeoniae Alba fine powder, mixing, drying under reduced pressure; pulverize; add the artificial Calculus Bovis, sieve mixing; granulate; drying, granulate adds Herba Asari volatile oil-Benexate Hydrochloride, Borneolum Syntheticum-Benexate Hydrochloride; mixing is made required dosage form.
Common dosage form and preparation method are:
The extractum compositions is pulverized, added binding agent, mixing is made granule.
The extractum compositions is pulverized, added disintegrating agent, binding agent, mixing is granulated, and is prepared into tablet.
The extractum compositions is pulverized, added disintegrating agent, binding agent, mixing,, be prepared into pill.
The extractum compositions is pulverized, granulated, add fluidizer and incapsulate, be prepared into capsule.
Best preparation method is: above ten simply, gets the Radix Angelicae Dahuricae and the 1/3 amount Radix Paeoniae Alba, mixes, and is ground into fine powder; Herba Asari is in addition cataclasm, and vapor distillation is collected volatile oil (medicinal residues, medicinal liquid keep standby), and volatile oil adds beta-schardinger dextrin-and makes clathrate; Borneolum Syntheticum adds beta-schardinger dextrin-and makes clathrate; Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae add 70% alcohol heating reflux three times, are followed successively by 2,1.5,1 hours, filter, and merging filtrate reclaims ethanol, and concentrated solution and last medicinal residues keep standby respectively; Radix Curcumae; Rhizoma Gastrodiae; Flos Chrysanthemi; the Radix Paeoniae Alba of Rhizoma Typhonii (system) and 2/3 amount is with Rhizoma Chuanxiong; Radix Salviae Miltiorrhizae; the medicinal residues of Herba Asari; medicinal liquid merges, and decocts with water three times; be followed successively by 2; 1.5; 1 hour, filter merging filtrate; concentrating under reduced pressure merges with above-mentioned alcohol extraction concentrated solution, continues to be concentrated into the clear paste that relative density is 1.30～1.35 (70 ℃); add the Radix Angelicae Dahuricae and 1/3 amount Radix Paeoniae Alba fine powder, mixing, drying under reduced pressure; pulverize; add the artificial Calculus Bovis, sieve mixing; granulate; drying, granulate adds Herba Asari volatile oil-Benexate Hydrochloride; Borneolum Syntheticum-Benexate Hydrochloride and magnesium stearate; mixing; be pressed into 1000, coating, promptly.
This product can be used for treating the diseases such as migraine of liver-wind folder blood stasis syndrome, for determining drug effect, this product has been carried out pharmacodynamics test research, and used tablet is by best proportioning of the present invention and optimum process preparation and get in the test.Concrete test is as follows:
1.1 animal
The SD rat, male and female half and half, body weight 300g ± 30g.The quarantine back is standby.
1.2 medicine
Getting this product, to be mixed with the medicinal liquid of 154.6% (every ml contains crude drug in whole 1.546g), 77.3% (every ml contains crude drug in whole 0.773g), 38.65% (every ml contains crude drug in whole 0.387g) with distilled water respectively standby; Ergotamine and caffeine tablet, every contains gynergen 1mg, and being mixed with every ml with distilled water, to contain the medicinal liquid of Ergotamine 0.2mg standby; Nitroglycerin injection, every ml contains nitroglycerin 5mg.
1.3 main agents
Calcitonin-gene-related peptide CGRP radioimmunity medicine box, Endothelin radioimmunoassay determination box, Beijing North biotechnology research institute; Histamine phosphate, Shanghai Inst. of Biochemistry, Chinese Academy of Sciences.
2 methods
2.1 grouping and modeling, medication are divided into blank group, Nerve in Migraine Model group, the high, medium and low dosage of this product and cafergot group at random with rat, and totally 6 groups, every group of 8 animals.By the group gastric infusion, the blank group does not deal with behind the modeling 30min, and model control group is irritated stomach distilled water 10ml/kg, and the cafergot group gives above-mentioned standby medicinal liquid 10ml/kg, and the large, medium and small dosage group of this product agent gives standby medicinal liquid 10ml/kg respectively.
2.2 draw materials, handle
Modeling 4h with the animal sacrificed by decapitation, collects the cervical region arteriovenous immediately and mixes the about 3ml of blood, injects the ice-cold test tube of the heparin sodium that contains 0.3mg, shake up gently, then, 4 ℃ of centrifugal 10min of 3000r/min, separated plasma is put into cryogenic refrigerator-20 ℃ storage by numbering, and is standby.
2.3 assay
2.3.1 the assay of CGRP (putting the method for exempting from) places room temperature to melt mixing again standby blood plasma in the animal pattern blood, once more 4 ℃ of centrifugal 10min of 3000r/min.Get supernatant 0.5ml, add the acid dehydrated alcohol (the 100ml dehydrated alcohol adds the 1.2ml glacial acetic acid) of 1ml, vibration 1min, 4 ℃ of centrifugal 15min of 3500r/min.The supernatant is poured in the penicillin bottle, 45 ℃ of water bath methods, (about 24h) adds a cover behind the sample bone dry, seals, and leaves with for-20 ℃.During mensuration, every bottle adds the PH7.4PBS0.5ml dissolving, and mixing is poured in the plastic test tube, leaves with more than the 4h for-20 ℃, after sample freezes fully, takes out and places.After dissolving fully under 4 ℃ of situations, get supernatant 200 μ l and detect.Get polystyrene test tube numbering, after CGRPR IA liquid feeding program is operated in the by specification, abundant mixing, room temperature is placed 20min, 4 ℃ of centrifugal 25min of 3500r/min; Supernatant is abandoned in suction, measures sedimentary radiocounting cpm in each pipe on the r enumerator, can directly obtain the blood concentration of the CGRP of sample on the FJ-2003r auto-counter.
2.3.2 the assay of ET (putting the method for exempting from) in the animal pattern blood
Place room temperature to melt mixing again standby blood plasma, 4 ℃ of centrifugal 5min of 3000r/min get the clear 100 μ l in upper strata and detect.Get polystyrene test tube numbering, in the by specification after the procedure operation of ETR IA liquid feeding, abundant mixing, room temperature is placed 15min, 4 ℃ of centrifugal 15min of 3500r/min, supernatant is abandoned in suction, surveys sedimentary radiocounting cpm in each pipe, can directly read the blood concentration of ET on the FJ-2003r auto-counter.
2.3.3 the assay of His (fluorescence method) in the animal pattern blood
Get standby anticoagulant heparin whole blood 0.25ml, add tri-distilled water 1.4ml, slowly add 25% (W/V) trichloroacetic acid 0.35ml, mixing, the centrifugal 10min of 4000r/min.Get supernatant 1.6ml, add 1.5g NaCl successively, 4ml n-butyl alcohol, 0.2ml2.5gNaOH, mixing immediately, vibration 5min, the centrifugal 3min of 4000r/min.Get 3.6ml n-butyl alcohol phase, add 1.2ml0.1NNaCl, the 2ml normal heptane, vibration 5min, the centrifugal 3min of 4000r/min abandons organic facies.Water intaking phase 1.0ml adds 1mlH2O, 0.5ml0.4NNaOH successively, behind the mixing, adds 0.1ml0.1% (W/V) OPT methanol solution rapidly, and 21～22 ℃ of reaction 10min add 0.5ml0.5NNaCl again.Measure the fluorescence intensity of His at the 360mm/440nm place.Standard control pipe: get the His standard application liquid of 0.5ml100ng/ml, add 0.5ml0.1NNaCl (His standard application liquid: 0.1ml100 μ g/mlHis liquid adds 0.1NHCl to 100ml).Blank pipe: add 1.0ml0.1NHCl.Calculate His content with following formula: His (ng/ml)=(sample fluorescence value-blank fluorescent value)/(standard fluorescence value-blank fluorescent value) * 286ng/ml whole blood).
2.4 statistical procedures is handled experimental data with the SPSS statistical software.Measurement data is represented with x ± s, compares between model control group and blank group, compares in twos between each administration group and model control group.
3 results
See Table 1.
Table 1 this product is to the influence of CGRP, ET in the Migraine Rats blood and His content (X ± s)
Compare * P＜0.05, P＜0.01 with the blank group; Compare △ △ P＜0.01 with model group; Compare zero △ △ P＜0.05, zero zero △ △ P＜0.01 with positive controls.
As can be seen from Table 1, model control group CGRP content obviously raises, and with the blank group utmost point significant difference (P＜0.01) is arranged relatively; This product high dose group animal CGRP content obviously reduces, and with model control group utmost point significant difference (P＜0.01) is arranged relatively, compares there was no significant difference (P＞0.05) with positive controls; In this product, CGRP content obviously reduces in the low dose group animal blood, with positive controls or model control group utmost point significant difference (P＜0.01) is arranged relatively in twos, in prompting this product, low dosage is better than this product high dose and cafergot to experimental migrainous therapeutic effect.ET content obviously reduces in the model control group blood, with the blank group utmost point significant difference (P＜0.01) is arranged relatively; ET content obviously raises in this product high dose group animal blood, with model control group or positive controls utmost point significant difference (P＜0.01) is arranged relatively in twos.In this product, low dose group and model control group or positive controls relatively have utmost point significant difference (P＜0.01), but in this product, ET content is starkly lower than positive controls in the low dose group animal blood, prompting this product high-dose therapy migraine effect is good than cafergot.
Model control group His content raises, and with blank group ratio significant difference (P＜0.05) is arranged; Each dosage group content of this product all obviously descends, and with model control group utmost point significance different (P＜0.01) is arranged relatively; But this product high dose group and positive control be there was no significant difference (P＞0.05) relatively, and the migrainous effect of dosage treatment is better than this product agent high dose and ergamine caffeine in the agent of prompting this product.
Below by implementing to further specify technical scheme of the present invention, but this applies for that claimed scope is not limited in the described content of embodiment.
The specific embodiment:
Embodiment 1
[prescription]
Rhizoma Chuanxiong 60g Radix Salviae Miltiorrhizae 50g Radix Curcumae 50g
Rhizoma Typhonii (system) 25g artificial Calculus Bovis 15g Rhizoma Gastrodiae 50g
Radix Paeoniae Alba 50g Flos Chrysanthemi 25g Radix Angelicae Dahuricae 50g
Herba Asari 10g Borneolum Syntheticum 1.5g
[method for making] above ten got the Radix Angelicae Dahuricae and the 1/3 amount Radix Paeoniae Alba simply, mixes, and is ground into fine powder; Herba Asari is in addition cataclasm, and vapor distillation is collected volatile oil (medicinal residues, medicinal liquid keep standby), and volatile oil adds beta-schardinger dextrin-and makes clathrate; Borneolum Syntheticum adds beta-schardinger dextrin-and makes clathrate; Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae add 70% alcohol heating reflux three times, are followed successively by 2,1.5,1 hours, filter, and merging filtrate reclaims ethanol, and concentrated solution and last medicinal residues keep standby respectively; Radix Curcumae; Rhizoma Gastrodiae; Flos Chrysanthemi; the Radix Paeoniae Alba of Rhizoma Typhonii (system) and 2/3 amount is with Rhizoma Chuanxiong; Radix Salviae Miltiorrhizae; the medicinal residues of Herba Asari; medicinal liquid merges, and decocts with water three times; be followed successively by 2; 1.5; 1 hour, filter merging filtrate; concentrating under reduced pressure merges with above-mentioned alcohol extraction concentrated solution, continues to be concentrated into the clear paste that relative density is 1.30～1.35 (70 ℃); add the Radix Angelicae Dahuricae and 1/3 amount Radix Paeoniae Alba fine powder, mixing, drying under reduced pressure; pulverize, add the artificial Calculus Bovis, sieve; mixing; granulate drying, granulate; add Herba Asari volatile oil-Benexate Hydrochloride; Borneolum Syntheticum-Benexate Hydrochloride; mixing adds Pulvis Talci 5g, and is encapsulated; make 500, promptly.
Embodiment 2
[prescription]
Rhizoma Chuanxiong 120g Radix Salviae Miltiorrhizae 100g Radix Curcumae 100g
Rhizoma Typhonii (system) 50g artificial Calculus Bovis 30g Rhizoma Gastrodiae 100g
Radix Paeoniae Alba 100g Flos Chrysanthemi 50g Radix Angelicae Dahuricae 100g
Herba Asari 20g Borneolum Syntheticum 3g
[method for making] above ten got the Radix Angelicae Dahuricae and the 1/3 amount Radix Paeoniae Alba simply, mixes, and is ground into fine powder; Herba Asari is in addition cataclasm, and vapor distillation is collected volatile oil (medicinal residues, medicinal liquid keep standby), and volatile oil adds beta-schardinger dextrin-and makes clathrate; Borneolum Syntheticum adds beta-schardinger dextrin-and makes clathrate; Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae add 70% alcohol heating reflux three times, are followed successively by 2,1.5,1 hours, filter, and merging filtrate reclaims ethanol, and concentrated solution and last medicinal residues keep standby respectively; Radix Curcumae; Rhizoma Gastrodiae; Flos Chrysanthemi; the Radix Paeoniae Alba of Rhizoma Typhonii (system) and 2/3 amount is with Rhizoma Chuanxiong; Radix Salviae Miltiorrhizae; the medicinal residues of Herba Asari; medicinal liquid merges, and decocts with water three times; be followed successively by 2; 1.5; 1 hour, filter merging filtrate; concentrating under reduced pressure merges with above-mentioned alcohol extraction concentrated solution, continues to be concentrated into the clear paste that relative density is 1.30～1.35 (70 ℃); add the Radix Angelicae Dahuricae and 1/3 amount Radix Paeoniae Alba fine powder; mixing, drying under reduced pressure is pulverized; add the artificial Calculus Bovis; sieve, mixing is granulated; dry; granulate adds Herba Asari volatile oil-Benexate Hydrochloride; Borneolum Syntheticum-Benexate Hydrochloride, mixing; 60 ℃ of dryings; add carboxymethylstach sodium 3g, microcrystalline Cellulose 12g, tabletting; make 1000, promptly.
Embodiment 3
[prescription]
Rhizoma Chuanxiong 240g Radix Salviae Miltiorrhizae 200g Radix Curcumae 200g
Rhizoma Typhonii (system) 100g artificial Calculus Bovis 60g Rhizoma Gastrodiae 200g
Radix Paeoniae Alba 200g Flos Chrysanthemi 100g Radix Angelicae Dahuricae 200g
Herba Asari 40g Borneolum Syntheticum 6g
[method for making] above ten got the Radix Angelicae Dahuricae and the 1/3 amount Radix Paeoniae Alba simply, mixes, and is ground into fine powder; Herba Asari is in addition cataclasm, and vapor distillation is collected volatile oil (medicinal residues, medicinal liquid keep standby), and volatile oil adds beta-schardinger dextrin-and makes clathrate; Borneolum Syntheticum adds beta-schardinger dextrin-and makes clathrate; Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae add 70% alcohol heating reflux three times, are followed successively by 2,1.5,1 hours, filter, and merging filtrate reclaims ethanol, and concentrated solution and last medicinal residues keep standby respectively; Radix Curcumae; Rhizoma Gastrodiae; Flos Chrysanthemi; the Radix Paeoniae Alba of Rhizoma Typhonii (system) and 2/3 amount is with Rhizoma Chuanxiong; Radix Salviae Miltiorrhizae; the medicinal residues of Herba Asari; medicinal liquid merges, and decocts with water three times; be followed successively by 2; 1.5; 1 hour, filter merging filtrate; concentrating under reduced pressure merges with above-mentioned alcohol extraction concentrated solution, continues to be concentrated into the clear paste that relative density is 1.30～1.35 (70 ℃); add the Radix Angelicae Dahuricae and 1/3 amount Radix Paeoniae Alba fine powder, mixing, drying under reduced pressure; pulverize; add the artificial Calculus Bovis, sieve mixing; granulate; drying, granulate adds Herba Asari volatile oil-Benexate Hydrochloride; Borneolum Syntheticum-Benexate Hydrochloride; mixing; 60 ℃ of dryings add microcrystalline Cellulose and adjust total amount to 1000g, make pill; dry; packing, every bag of 5g, promptly.
Claims (6)
1. treat migrainous Chinese medicine composition for one kind; it is characterized in that said composition made by following medicaments in part by weight: Rhizoma Chuanxiong 60～180 weight portions, Radix Salviae Miltiorrhizae 50～150 weight portions, Radix Curcumae 50～150 weight portions; Rhizoma Typhonii (processed) 25～75 weight portions; artificial Calculus Bovis's 15～45 weight portions, Rhizoma Gastrodiae 50～150 weight portions, the Radix Paeoniae Alba 50～150 weight portions; Flos Chrysanthemi 25～75 weight portions; the Radix Angelicae Dahuricae 50～150 weight portions, Herba Asari 10～30 weight portions, Borneolum Syntheticum 1～5 weight portion.
2. Chinese medicine composition according to claim 1; it is characterized in that said composition preferred weight ratio be: Rhizoma Chuanxiong 120 weight portions, Radix Salviae Miltiorrhizae 100 weight portions, Radix Curcumae 100 weight portions; Rhizoma Typhonii (processed) 50 weight portions; artificial Calculus Bovis's 30 weight portions, Rhizoma Gastrodiae 100 weight portions, the Radix Paeoniae Alba 100 weight portions; Flos Chrysanthemi 50 weight portions; the Radix Angelicae Dahuricae 100 weight portions, Herba Asari 20 weight portions, Borneolum Syntheticum 3 weight portions.
3. Chinese medicine composition according to claim 1 and 2 is characterized in that said composition makes capsule, tablet, pill, granule.
4. the preparation method of Chinese medicine composition according to claim 3, the preparation method that it is characterized in that said composition be as follows: get crude drug, with the Radix Angelicae Dahuricae and the 1/3 amount Radix Paeoniae Alba, mix, be ground into fine powder; Herba Asari is in addition cataclasm, and vapor distillation is collected volatile oil, and medicinal residues, medicinal liquid keep standby, and volatile oil adds beta-schardinger dextrin-and makes clathrate; Borneolum Syntheticum adds beta-schardinger dextrin-and makes clathrate; Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae add 70% alcohol heating reflux 2～4 times, filter, and merging filtrate reclaims ethanol, and concentrated solution and last medicinal residues keep standby respectively; The Radix Paeoniae Alba of Radix Curcumae, Rhizoma Gastrodiae, Flos Chrysanthemi, Rhizoma Typhonii (processed) and 2/3 amount, medicinal residues, medicinal liquid merging with Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Herba Asari decoct with water 2～4 times; filter; merging filtrate, concentrating under reduced pressure merges with above-mentioned alcohol extraction concentrated solution; relative density is 1.30～1.35 clear paste when continuing to be concentrated into 70 ℃; add the Radix Angelicae Dahuricae and 1/3 amount Radix Paeoniae Alba fine powder, mixing, drying under reduced pressure; pulverize; add the artificial Calculus Bovis, sieve mixing; granulate; drying, granulate adds Herba Asari volatile oil-Benexate Hydrochloride, Borneolum Syntheticum-Benexate Hydrochloride; mixing is made required dosage form.
5. the preparation method of Chinese medicine composition according to claim 4, the preparation method that it is characterized in that said composition be as follows: get crude drug, with the Radix Angelicae Dahuricae and the 1/3 amount Radix Paeoniae Alba, mix, be ground into fine powder; Herba Asari is in addition cataclasm, and vapor distillation is collected volatile oil, and medicinal residues, medicinal liquid keep standby, and volatile oil adds beta-schardinger dextrin-and makes clathrate; Borneolum Syntheticum adds beta-schardinger dextrin-and makes clathrate; Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae add 70% alcohol heating reflux three times, are followed successively by 2,1.5,1 hours, filter, and merging filtrate reclaims ethanol, and concentrated solution and last medicinal residues keep standby respectively; Radix Curcumae; Rhizoma Gastrodiae; Flos Chrysanthemi; the Radix Paeoniae Alba of Rhizoma Typhonii (processed) and 2/3 amount is with Rhizoma Chuanxiong; Radix Salviae Miltiorrhizae; the medicinal residues of Herba Asari; medicinal liquid merges, and decocts with water three times; be followed successively by 2; 1.5; 1 hour, filter merging filtrate; concentrating under reduced pressure; merge with above-mentioned alcohol extraction concentrated solution, relative density is 1.30～1.35 clear paste when continuing to be concentrated into 70 ℃, adds the Radix Angelicae Dahuricae and 1/3 amount Radix Paeoniae Alba fine powder; mixing; drying under reduced pressure is pulverized, and adds the artificial Calculus Bovis; sieve; mixing is granulated drying; granulate; add Herba Asari volatile oil-Benexate Hydrochloride; Borneolum Syntheticum-Benexate Hydrochloride, mixing is made required dosage form.
6. Chinese medicine composition according to claim 1 and 2 is used for the treatment of disease in preparation and sees head distending pain, twinge or jumping pain, see with frontal temporal part pain more, or with dizzy, emotion is not smooth, or susceptible to lose temper due to restlessness, uneasy sleeping at night, dry mouth with bitter taste, red tongue or petechia is arranged, yellow and thin fur, the application in the migrainous medicine of the liver-wind hemicrania that stringy pulse or string are puckery.
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| CN101181592B (en) * | 2007-11-27 | 2010-07-14 | 田锦林 | Chinese medicine for curing intractable headache and sick headache |
| CN102670017A (en) * | 2012-05-09 | 2012-09-19 | 太仓市伟基生物科技有限公司 | Traditional Chinese medicine pillow capable of treating migraine |
| CN102813886B (en) * | 2012-08-20 | 2014-05-07 | 魏杰梅 | Traditional Chinese medicine preparation for treating migraine |
| CN103239691B (en) * | 2013-05-30 | 2014-10-29 | 通化金马药业集团股份有限公司 | Application of medicine composition in preparation of medicaments for treating headache |
| CN103550351B (en) * | 2013-10-25 | 2015-08-19 | 黄文珍 | Chinese medicine composition for the treatment of migraine and preparation method thereof |
| CN104435467A (en) * | 2014-12-05 | 2015-03-25 | 周元宏 | Medicine for treating neck-shoulder syndrome and cervical gear matched in use with same |
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| CN1169292A (en) * | 1996-06-21 | 1998-01-07 | 刘庆海 | Preparation of traditional Chinese herbs for treatment of cephalagra |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1169292A (en) * | 1996-06-21 | 1998-01-07 | 刘庆海 | Preparation of traditional Chinese herbs for treatment of cephalagra |
Non-Patent Citations (1)
| Title |
|---|
| 药典委员会.熄风通络头痛片.国家新药转正标准.2005,(x71),96. * |
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| CN1943757A (en) | 2007-04-11 |
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