CN1942579B - 将氧化还原活性氨基酸位点特异地掺入蛋白质 - Google Patents

将氧化还原活性氨基酸位点特异地掺入蛋白质 Download PDF

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Publication number
CN1942579B
CN1942579B CN2004800301376A CN200480030137A CN1942579B CN 1942579 B CN1942579 B CN 1942579B CN 2004800301376 A CN2004800301376 A CN 2004800301376A CN 200480030137 A CN200480030137 A CN 200480030137A CN 1942579 B CN1942579 B CN 1942579B
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trna
quadrature
cell
amino acids
codon
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CN1942579A (zh
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L·阿方达
P·G·舒尔茨
张致文
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Scripps Research Institute
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

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  • Molecular Biology (AREA)
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  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN2004800301376A 2003-10-14 2004-10-13 将氧化还原活性氨基酸位点特异地掺入蛋白质 Expired - Fee Related CN1942579B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51153203P 2003-10-14 2003-10-14
US60/511,532 2003-10-14
PCT/US2004/034089 WO2005038002A2 (en) 2003-10-14 2004-10-13 Site-specific incorporation of redox active amino acids into proteins

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CN200910004743A Division CN101532046A (zh) 2003-10-14 2004-10-13 将氧化还原活性氨基酸位点特异地掺入蛋白质

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CN1942579A CN1942579A (zh) 2007-04-04
CN1942579B true CN1942579B (zh) 2013-06-26

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CN200910004743A Pending CN101532046A (zh) 2003-10-14 2004-10-13 将氧化还原活性氨基酸位点特异地掺入蛋白质

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US (5) US7494796B2 (https=)
EP (1) EP1687401B1 (https=)
JP (1) JP5657850B2 (https=)
CN (2) CN1942579B (https=)
AU (1) AU2004282577B2 (https=)
BR (1) BRPI0415308A (https=)
CA (1) CA2541166A1 (https=)
DK (1) DK1687401T3 (https=)
ES (1) ES2396712T3 (https=)
IL (3) IL174947A (https=)
MX (1) MXPA06004087A (https=)
PL (1) PL1687401T3 (https=)
PT (1) PT1687401E (https=)
WO (1) WO2005038002A2 (https=)

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WO2002085923A2 (en) * 2001-04-19 2002-10-31 The Scripps Research Institute In vivo incorporation of unnatural amino acids
MXPA05003978A (es) * 2002-10-16 2005-06-22 Scripps Research Inst Sintesis de glicoproteinas.
JP5642916B2 (ja) 2003-04-17 2014-12-17 ザ スクリプス リサーチ インスティテュート 真核遺伝コードの拡張
EP2410331B1 (en) 2003-06-18 2015-09-23 The Scripps Research Institute Aminoacyl-tRNA synthetase for aminoacylation tRNA with unnatural amino acids
EP1649004A4 (en) * 2003-07-07 2008-04-09 Scripps Research Inst COMPOSITIONS WITH PAIRS OF ORTHOGONAL LYSYL-TRNA AND AMINOACYL-TRNA-SYNTHETASE AND USES THEREOF
JP2008500050A (ja) * 2004-05-25 2008-01-10 ザ スクリップス リサーチ インスティテュート 結晶構造決定のための重原子含有非天然アミノ酸の部位特異的蛋白質組込み
DE102004031258A1 (de) * 2004-06-29 2006-02-09 Jennissen, Herbert P., Prof. Dr. Proteinhybride mit polyhydroxyaromatischen Aminosäure-Epitopen
US20080171317A1 (en) * 2004-09-22 2008-07-17 The Scripps Research Institute Site-Specific Labeling of Proteins for Nmr Studies
CN101048506B (zh) 2004-10-27 2013-06-26 斯克利普斯研究院 体内掺入非天然氨基酸的正交翻译组分
BRPI0617191A2 (pt) * 2005-10-12 2011-07-19 Scripps Research Inst modificação pós-traducional de polipeptìdeos expressos em fagos
WO2007092475A2 (en) * 2006-02-06 2007-08-16 Franklin And Marshall College Site-specific incorporation of fluorinated amino acids into proteins
KR20080106430A (ko) * 2006-03-09 2008-12-05 더 스크립스 리서치 인스티튜트 진정 세균 숙주 세포 내에서의 직교형 번역 성분의 발현을 위한 시스템
WO2007109035A2 (en) 2006-03-16 2007-09-27 The Scripps Research Institute Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine
AU2007267950B2 (en) * 2006-05-23 2012-08-16 The Scripps Research Institute Genetically encoded fluorescent coumarin amino acids
JP5385143B2 (ja) * 2006-09-21 2014-01-08 ザ スクリプス リサーチ インスティチュート 真正細菌における選択的に硫酸化された蛋白質の遺伝的にプログラムされた発現
WO2008073184A2 (en) 2006-10-18 2008-06-19 The Scripps Research Institute Genetic incorporation of unnatural amino acids into proteins in mammalian cells
WO2008137452A1 (en) * 2007-05-04 2008-11-13 Kenergy Royalty Company, Llc Implantable high efficiency digital stimulation device
US8673591B2 (en) 2007-10-25 2014-03-18 The Scripps Research Institute Genetic incorporation of 3-aminotyrosine into reductases
WO2009059056A2 (en) * 2007-11-02 2009-05-07 The Scripps Research Institute A genetically encoded boronate amino acid
JP5513398B2 (ja) * 2007-11-02 2014-06-04 ザ スクリプス リサーチ インスティチュート 非天然アミノ酸を含有する蛋白質を使用する指向的進化
CN101939410A (zh) 2007-12-11 2011-01-05 斯克利普斯研究院 甲基营养酵母菌巴斯德毕赤酵母中的体内非天然氨基酸表达
EP2249865A4 (en) * 2008-02-08 2012-04-04 Scripps Research Inst BREAKING IMMUNOLOGICAL TOLERANCE WITH A GENETICALLY ENCODED UNNATURAL AMINO ACID
JP2012511403A (ja) * 2008-12-09 2012-05-24 クック メディカル テクノロジーズ エルエルシー 鋲留め器具の制御放出のための装置と方法
US8609383B2 (en) 2008-12-10 2013-12-17 The Scripps Research Institute Production of carrier-peptide conjugates using chemically reactive unnatural amino acids
US20090197339A1 (en) * 2008-12-10 2009-08-06 The Scripps Research Institute In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris
WO2010089741A1 (en) * 2009-02-04 2010-08-12 Ben-Gurion University Of The Negev Research And Development Authority Systems and methods for bio-electricity production
JP6574754B2 (ja) 2013-03-19 2019-09-11 ベイジン シェノゲン ファーマ グループ リミテッド エストロゲン受容体関連疾患を処置するための抗体及び方法
US20150331624A1 (en) * 2014-05-19 2015-11-19 Kabushiki Kaisha Toshiba Host-controlled flash translation layer snapshot
KR101956042B1 (ko) * 2017-07-13 2019-03-08 서강대학교산학협력단 표적 단백질 내 l-디하이드록시페닐알라닌의 도입 방법
EP3983501B1 (en) 2019-06-17 2025-02-26 Merck Patent GmbH Liquid crystal-based light valve

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1231697A (zh) * 1996-08-29 1999-10-13 麻省理工学院 体内蛋白质合成的方法

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Publication number Priority date Publication date Assignee Title
WO2002085923A2 (en) 2001-04-19 2002-10-31 The Scripps Research Institute In vivo incorporation of unnatural amino acids
MXPA05003978A (es) 2002-10-16 2005-06-22 Scripps Research Inst Sintesis de glicoproteinas.
JP4444113B2 (ja) 2002-10-16 2010-03-31 ザ スクリップス リサーチ インスティテュート ケトアミノ酸の部位特異的蛋白質組込み方法
CA2508939A1 (en) 2002-12-22 2004-07-15 The Scripps Research Institute Protein arrays
JP5642916B2 (ja) 2003-04-17 2014-12-17 ザ スクリプス リサーチ インスティテュート 真核遺伝コードの拡張
EP2410331B1 (en) 2003-06-18 2015-09-23 The Scripps Research Institute Aminoacyl-tRNA synthetase for aminoacylation tRNA with unnatural amino acids
WO2005007624A2 (en) 2003-07-07 2005-01-27 The Scripps Research Institute Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof
EP1649004A4 (en) 2003-07-07 2008-04-09 Scripps Research Inst COMPOSITIONS WITH PAIRS OF ORTHOGONAL LYSYL-TRNA AND AMINOACYL-TRNA-SYNTHETASE AND USES THEREOF
US20060160175A1 (en) 2003-07-07 2006-07-20 The Scripps Research Institute Compositions of orthogonal leucyl-trna and aminoacyl-trna synthetase pairs and uses thereof

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
CN1231697A (zh) * 1996-08-29 1999-10-13 麻省理工学院 体内蛋白质合成的方法

Non-Patent Citations (1)

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Q57834(登录号).EBI,1997, *

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DK1687401T3 (da) 2013-02-04
ES2396712T3 (es) 2013-02-25
US20120100570A1 (en) 2012-04-26
AU2004282577B2 (en) 2009-10-29
PL1687401T3 (pl) 2013-04-30
BRPI0415308A (pt) 2006-12-05
IL174947A0 (en) 2006-08-20
CN101532046A (zh) 2009-09-16
US9783798B2 (en) 2017-10-10
CA2541166A1 (en) 2005-04-28
CN1942579A (zh) 2007-04-04
US8114654B2 (en) 2012-02-14
WO2005038002A2 (en) 2005-04-28
EP1687401B1 (en) 2012-11-21
US20050227318A1 (en) 2005-10-13
IL201705A0 (en) 2011-08-01
JP2007508034A (ja) 2007-04-05
US20090298124A1 (en) 2009-12-03
JP5657850B2 (ja) 2015-01-21
US20070009990A1 (en) 2007-01-11
IL206889A0 (en) 2010-12-30
WO2005038002A3 (en) 2006-11-23
EP1687401A2 (en) 2006-08-09
AU2004282577A1 (en) 2005-04-28
IL174947A (en) 2011-11-30
US7494796B2 (en) 2009-02-24
US8008041B2 (en) 2011-08-30
EP1687401A4 (en) 2007-08-01
PT1687401E (pt) 2013-02-26
US7811801B2 (en) 2010-10-12
US20110008782A1 (en) 2011-01-13
MXPA06004087A (es) 2006-06-27

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