CN1926113B - 新的酰氨基取代的羟基-6-苯基菲啶化合物及其作为pde4抑制剂的应用 - Google Patents

新的酰氨基取代的羟基-6-苯基菲啶化合物及其作为pde4抑制剂的应用 Download PDF

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Publication number
CN1926113B
CN1926113B CN2005800068554A CN200580006855A CN1926113B CN 1926113 B CN1926113 B CN 1926113B CN 2005800068554 A CN2005800068554 A CN 2005800068554A CN 200580006855 A CN200580006855 A CN 200580006855A CN 1926113 B CN1926113 B CN 1926113B
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hydrogen
4ars
10brs
alkyl
hydroxyl
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Chinese (zh)
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CN1926113A (zh
Inventor
U·考茨
B·施密德特
D·弗洛克茨
A·哈策尔曼
C·齐特
J·巴西
D·马克斯
H·-P·克利
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Takeda GmbH
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Nycomed GmbH
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    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
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    • C07D221/10—Aza-phenanthrenes
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    • A61K31/47—Quinolines; Isoquinolines
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CN2005800068554A 2004-03-10 2005-03-09 新的酰氨基取代的羟基-6-苯基菲啶化合物及其作为pde4抑制剂的应用 Expired - Fee Related CN1926113B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP04100990.3 2004-03-10
EP04100990 2004-03-10
EP04106677.0 2004-12-17
EP04106677 2004-12-17
PCT/EP2005/051054 WO2005087745A1 (en) 2004-03-10 2005-03-09 Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors

Publications (2)

Publication Number Publication Date
CN1926113A CN1926113A (zh) 2007-03-07
CN1926113B true CN1926113B (zh) 2010-06-23

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CN2005800068554A Expired - Fee Related CN1926113B (zh) 2004-03-10 2005-03-09 新的酰氨基取代的羟基-6-苯基菲啶化合物及其作为pde4抑制剂的应用

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Country Link
US (1) US20070185149A1 (enExample)
EP (1) EP1725534A1 (enExample)
JP (1) JP2007527901A (enExample)
KR (1) KR20060130697A (enExample)
CN (1) CN1926113B (enExample)
AR (1) AR049324A1 (enExample)
AU (1) AU2005221832A1 (enExample)
BR (1) BRPI0508481A (enExample)
CA (1) CA2558391A1 (enExample)
IL (1) IL177496A0 (enExample)
MX (1) MXPA06009892A (enExample)
NO (1) NO20064415L (enExample)
NZ (1) NZ549254A (enExample)
TW (1) TW200600499A (enExample)
WO (1) WO2005087745A1 (enExample)

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EP1720835B1 (en) 2004-02-18 2012-12-12 Nycomed GmbH Novel guanidinyl-substituted hydroxy-6-phenylphenanthridines as effective phosphodiesterase (pde) 4 inhibitors
HRP20130828T1 (en) 2004-03-03 2013-09-30 Takeda Gmbh Novel hydroxy-6-heroarylphenanthridines and their use as pde4 inhibitors
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US7838521B2 (en) 2004-09-08 2010-11-23 Nycomed Gmbh 3-oxa-10-aza-phenanthrenes
NZ560268A (en) 2005-03-02 2010-12-24 Nycomed Gmbh Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
US20100041662A1 (en) 2006-10-30 2010-02-18 Sandrine Ferrand Heterocyclic compounds as antiinflammatory agents
JP5362729B2 (ja) 2007-10-04 2013-12-11 エフ．ホフマン−ラ ロシュ アーゲー シクロプロピルアリールアミド誘導体及びその使用
WO2009087224A1 (en) 2008-01-11 2009-07-16 Novartis Ag Pyrimidines as kinase inhibitors
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UY33597A (es) 2010-09-09 2012-04-30 Irm Llc Compuestos y composiciones como inhibidores de la trk
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
JP5959541B2 (ja) 2011-02-25 2016-08-02 ノバルティス アーゲー Ｔｒｋ阻害剤としてのピラゾロ［１，５−ａ］ピリジン

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WO2005087745A8 (en) 2006-10-26
AR049324A1 (es) 2006-07-19
KR20060130697A (ko) 2006-12-19
JP2007527901A (ja) 2007-10-04
NO20064415L (no) 2006-10-10
AU2005221832A1 (en) 2005-09-22
BRPI0508481A (pt) 2007-07-31
US20070185149A1 (en) 2007-08-09
EP1725534A1 (en) 2006-11-29
TW200600499A (en) 2006-01-01
WO2005087745A1 (en) 2005-09-22
MXPA06009892A (es) 2007-03-01
CN1926113A (zh) 2007-03-07
CA2558391A1 (en) 2005-09-22
IL177496A0 (en) 2006-12-10

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