CN1911400B - Compound poria cocos preparation, and its preparation method - Google Patents
Compound poria cocos preparation, and its preparation method Download PDFInfo
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- CN1911400B CN1911400B CN2005100287375A CN200510028737A CN1911400B CN 1911400 B CN1911400 B CN 1911400B CN 2005100287375 A CN2005100287375 A CN 2005100287375A CN 200510028737 A CN200510028737 A CN 200510028737A CN 1911400 B CN1911400 B CN 1911400B
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Abstract
A Chinese medicine for preventing and treating hepatitis is prepared from 23 Chinese-medicinal materials including tuckahoe, mica powder, dodder seed, pilose asiabell root, etc. Its preparing process is also disclosed.
Description
Technical field:
The invention belongs to technical field of Chinese medicines.Be specifically related to a kind of compound poria cocos preparation and preparation method thereof.
Background technology:
Hepatitis is a kind of more common infectious disease, and especially in the Asia and some undeveloped countries and area, the sickness rate of hepatitis is higher.The medicine of general therapeutic hepatitis has multiple, and is satisfactory but curative effect is still failed, and some patient regular meeting is transformed into chronic hepatitis, and the patient's prolonged illness that has causes hepatic fibrosis or liver cirrhosis etc.And chemical medicine is also often with side effect, thereby people are devoted to study the Chinese herbal medicine that can treat hepatitis.More existing at present Chinese medicine preparation come out, and are used for the treatment of the more clinical effects of hepatitis.Treating hepatitis is divided into three main paties at present.
1, antiviral therapy and application of interference element.Viral interference is duplicated the heredity with DNA.Wherein the medicine of immunological surveillance and control does not have.Common lamivudine, interferon and Recombinant Interferon, Coriolous Dersicolor (Fr.) Quel born of the same parents' class glycopeptide class.Comprise and supervise the treatment of ordering prescription drugs.(Chinese medicine)
2, play protection hepatocyte injury class medicine.
Common legalon, liver-protecting tablet, Radix Ginseng must first be fried in shallow oil ball etc.
3, to symptom class medicine: Herba Sedi granule, jaundice YINZHEN electuary, glycyrrhizin tablet etc.
Also have blood-activating stasis-removing kind by motherland's theory of medicine except that above-mentioned three classes, soft liver class holds up soil to press down wooden class etc.To order application at prison more extensive for these treatment rules, neither the human five internal organs treats the application of factor universal rule.Neither treat hepatitis pattern preferably.
The regular pattern of man and nature and the pattern rule of human five internal organs and six internal organs can be signed for borrowing on treatment hepatitis and in the health preserving.The various countries scientist makes great efforts energetically, changes ataloss at present, and break through direction and various approach are sought in attempt.But wish to research and develop more effective Chinese medicine preparation.
Summary of the invention:
Technical problem to be solved by this invention is to overcome above-mentioned weak point, the Chinese medicine preparation of the more effective treatment hepatitis of research design.
The invention provides a kind of Chinese medicine compound poria cocos preparation (having another name called the Sun Shi Poria looses).This compound poria cocos preparation is the achievement of the inventor through studying for a long period of time and drawing.
Chinese medicine compound poria cocos preparation of the present invention is made up of 23 flavor Chinese medicines and pharmaceutic adjuvant.
The principles of formulating prescriptions that the Sun Shi Poria looses:
Monarch drug: Poria, Stalactitum, mica powder, Sichuan Herba Dendrobii, Rhizoma Acori Graminei;
Ministerial drug: Semen Platycladi, Semen Cuscutae, Radix Dipsaci, the Cortex Eucommiae, Radix Asparagi, Radix Achyranthis Bidentatae, Fructus Schisandrae Chinensis;
Adjuvant drug: Rhizoma Alismatis, Radix Polygalae, Flos Chrysanthemi, Fructus Cnidii;
Messenger drug: Rhizoma dioscoreae, Radix Aconiti Lateralis Preparata, Folium Pyrrosiae, Radix Rehmanniae Preparata, Herba Cistanches, Cortex Cinnamomi, Radix Codonopsis.
The action principle of compound poria cocos preparation:
Monarch drug: Poria, Stalactitum, mica powder, Sichuan Herba Dendrobii, Rhizoma Acori Graminei;
At first act on taste, remake and be used for liver, the heart, spleen, lung, kidney, reduce phlegm and internal heat and wash disease, calm the nerves.
Ministerial drug: Semen Platycladi, Semen Cuscutae, Radix Dipsaci, the Cortex Eucommiae, Radix Asparagi, Radix Achyranthis Bidentatae, Fructus Schisandrae Chinensis;
Extreme misery is numerous, (coordination between the heart and kidney).Open-minded by lung qi, the intersecting of heart kidney, wherein Radix Asparagi and Fructus Schisandrae Chinensis draw gas downwards.Gas is not up breathed heavily.
Adjuvant drug: Rhizoma Alismatis, Radix Polygalae, Flos Chrysanthemi, Fructus Cnidii;
Conscience lung kidney is strengthened.Dizziness and blurred vision is good, sleeps.Blood pressure must be kept.
Messenger drug: Rhizoma dioscoreae, Radix Aconiti Lateralis Preparata, Folium Pyrrosiae, Radix Rehmanniae Preparata, Herba Cistanches, Cortex Cinnamomi, Radix Codonopsis;
Can the heart strengthening and the mind tranquilizing.Wherein Semen Platycladi and Radix Rehmanniae Preparata nourish blood, nourish heart, repose.Can make hair not white.To spleen, cardiopulmonary kidney, liver pain (promptly being commonly called as ambition stomachache) and extremities joint pain.
Radix Codonopsis has the effect of commander's gas and has effect under one's command at this.
The weight percent of the Chinese medicine each component that compound poria cocos looses is:
Poria 3-11 Stalactitum 3-11 mica powder 3-11 Sichuan Herba Dendrobii 2-8
Rhizoma Acori Graminei 2-8 Semen Platycladi 3-11 Semen Cuscutae 2-8 Radix Dipsaci 2-8
Cortex Eucommiae 2-8 Radix Asparagi 2-8 Radix Achyranthis Bidentatae 2-8 Fructus Schisandrae Chinensis 2-8
Rhizoma Alismatis 2-8 Cortex et Radix Polygalae (processed) 2-8 Flos Chrysanthemi 2-8 Fructus Cnidii 2-8
Rhizoma dioscoreae 2-8 Radix Aconiti Lateralis Preparata 2-8 Folium Pyrrosiae (unhairing) 2-8 Radix Rehmanniae Preparata 2-8
Herba Cistanches 2-8 Cortex Cinnamomi 2-8 Radix Codonopsis 2-8
Poria cocos preparation of the present invention has remarkable result after taking, for example Xia Mian concrete effect:
Medicine is formed:
Poria 250 gram Stalactitums 200 gram mica powders 200 gram Sichuan Herba Dendrobiis 200 grams
Rhizoma Acori Graminei 200 gram Semen Platycladi 250 gram Semen Cuscutae 200 gram Radix Dipsaci 200 grams
The Cortex Eucommiae 200 gram Radix Asparagi 200 gram Radix Achyranthis Bidentataes 200 gram Fructus Schisandrae Chinensis 200 grams
Rhizoma Alismatis 200 gram Cortex et Radix Polygalae (processed) 200 gram Flos Chrysanthemis 200 gram Fructus Cnidiis 200 grams
Rhizoma dioscoreae 200 is restrained Radix Aconiti Lateralis Preparata 200 gram Folium Pyrrosiaes (unhairing) 200 gram Radix Rehmanniae Preparata 200 grams
Herba Cistanches 200 gram Cortex Cinnamomis 200 gram Radix Codonopsis 200 grams
All the porphyrize powder is packed as 4 sacks, 10 grams, one parcel, and patients is taken.Every day three times, hydromel or warm water delivery service.
Case 1: grandson XX takes 3 months compound poria cocos and looses
Be in particular in:
1. sleep (hepatopath sleeps not good more than 85%)
2. appetite is good, outeat, zestful.(about 4 liang of appetite 2 little bowls)
3. in high spirits, full of vitality, do not need break high noon.
4. waist, lower limb, foot are not felt acid,
It is on and off duty to send from driving after taking one month, 45 minutes distance.
Former stopped to ride feel to ride three days motionless, had desire by bike after taking medicine one month:
Wherein one-time continuous was ridden 10 hours; Once rode 8 hours.
5. breakdown test.
6. early-heart-beating is effective.Take after the week and feel to make moderate progress.
7. take and feel obviously after one month that liver has tangible twinge, the inventor thinks to liver in when treatment, meets the rule of " general rule not bitterly, stagnation of QI and blood may bring about pain ", and twinge is pressed; Twinge; Pure pain; Drilling pain; Indirectly bitterly; Classification such as lasting pain.Why have twinge.Since secular gloomy, the depression of liver-QI of mood, a labor among the five kinds of over strain.
Under the different time different situations, once occurred the secondary pain later on, but degree is light time by time.Almost there was not any discomfort in three month.
8. taste aspect: stomach is had some stimulations.
Suitable one after each meal.
Will become to doing after two days steadily, two days laundering period is just arranged.
After three months, stomach is except gas on some, and all the other are all good.The reason of last gas is relevant with mood.Then turn better day by day later on.
9. lung aspect: going up sense does not almost have, and does not have sending out the phase well yet.
10. kidney aspect: erection function is normal after morning, and do not get up in the night to urinate evening, drinks under 1 glass of boiled water situation about 400 milliliters evening, will urinate once more than two glasss.About 3000 milliliters of the water uptake of every day.Do not comprise in the diet.
11. audition is better, does not have deaf phenomenon, tooth is also fine.
Former some senilism phenomenon comprises physiology, psychological aspects, and is existing very substantial.
12. xerostomia, bitter taste phenomenon obviously change (belonging to liver).
The above results shows that compound poria cocos preparation of the present invention can be used for deficiency of liver-QI and the various hepatitis that cause.
Case two:
(grandson XX) 81 years old suffered from history of hypertension 50 years.
2005.3.5 day, begin to obey compound poria cocos and loose, because of having blood pressure machine, jede Woche is surveyed once.
Blood pressure BP110/200mmHg often has early rich property arrhythmia.
Oral each 10 gram every days 3 times, feel to take the powder difficulty after three weeks, do not take medicine custom, change each 5 into and restrain every day three times.
110/180mmHg on the 27th every day 3 times in March a Zhenju Jiangya Tablet
100/160mmHg on the 10th every day 3 times in April a Zhenju Jiangya Tablet
90/170mmHg on the 24th every day 3 times in April a Zhenju Jiangya Tablet
80/180mmHg on the 30th every day 3 times in April a Zhenju Jiangya Tablet
80/170mmHg on the 15th every day 3 times in May a Zhenju Jiangya Tablet
90/200mmHg on May 21 (not taking medicine)
Added about 5 grams of the powder that connects with the heart on May 28, three Radix Panacis Quinquefoliis drink compound poria cocos of making tea loose and to continue to take every day.(about 5 grams)
June 11 80/180-190mmHg
80/140mmHg on the 9th every day three times 80/150mmHg on the 18th 80/140mmHg-7 month June 25 in June a Zhenju Jiangya Tablet.
Above-mentionedly show that compound poria cocos of the present invention looses except going into the liver taste, can also improve cardiovascular function.
Another object of the present invention has provided the preparation method that the Chinese medicine preparation compound poria cocos looses, method improvement of the present invention traditional decocting method, and adopt the method for high-temperature pressurizing therein, the active ingredient of Chinese medicine can be extracted better.
Preparation method of the present invention is to get the clean Chinese medicine of respectively distinguishing the flavor of, and has put into two covers, heating, and in the reactor of voltage adjusting device, add the water that 0.6-6 doubly measures, soak half an hour, then under 175-115 ℃ temperature and 0.1Mpa-0.2Mpa pressure, decocted 0.5-0.75 hour, decoct and finish, continue insulation ten minutes, emit medicinal liquid, enter that the direct bag distribution packaging of packer becomes oral liquid or, add adjuvant and make various preparations by the medicine routine fashion.
Method of the present invention is easy, is suitable for suitability for industrialized production.
Compound poria cocos animality toxicity test report of the present invention is as follows:
Summary
Totally 20 of Kunming mouses, male and female half and half give compound poria cocos by oral being administered once property respectively and loose, and observe the mortality rate of animal in a week.The result: medicine is 20g/kg to the maximum dosage-feeding of mice.
Purpose
Observe acute toxicity reflection and the mortality rate of mice, record the maximum dosage-feeding of medicine mice to compound poria cocos.
Material
Medicine
Compound poria cocos is provided by Affiliated Hospital of Fudan University, add tween and grind, and with the normal saline dilution, the maximum concentration of this medicine is 0.5g/ml.
Animal
Kunming mouse, male and female half and half, 18-22g is provided by pharmacological room of Shanghai Institute of Pharmaceutical Industry Animal House.The raising condition: it is 21-22 ℃ that central air-conditioning is kept room temperature, and relative humidity is 60%-65%, freely intakes.Fasting is 6 hours before the administration.
Method
Through the definite Cmax of prerun with this medicine, 0.8ml/20g administration volume gastric infusion, mice does not all have death.20 of mices, male and female half and half are with the 20g/kg administration.Observe a week continuously after the medication.Record mouse toxicity reaction and death toll day by day.Dead mice carries out obduction, the pathological change of perusal vitals.
The result
Animal does not all have dead after medication in the week, animal activity, diet, drainage are all acted normally, and body weight is normal growth also.
Conclusion
Mice records the mortality rate of animal in a week with Cmax, maximum administration volume, by irritating the disposable administration of stomach, our experiments show that compound poria cocos is 20g/kg to the maximum dosage-feeding of mice.
Compound poria cocos preparation of the present invention comprises oral granular formulation (electuary), tablet, pill, powder, lozenge, soft extract, colloid, syrup, mixture, drop pill, capsule, medicated wine; The plaster of fluid extract and extractum or injection or external, rubber-emplastrum, ointment, distillate medicinal water, liniment or suppository.
The specific embodiment:
Example 1
Prescription:
Poria 3 gram Stalactitums 3 gram mica powders 3 gram Sichuan Herba Dendrobiis 2 grams
Rhizoma Acori Graminei 2 gram Semen Platycladi 3 gram Semen Cuscutae 2 gram Radix Dipsaci 2 grams
The Cortex Eucommiae 2 gram Radix Asparagi 3 gram Radix Achyranthis Bidentataes 2 gram Fructus Schisandrae Chinensis 2 grams
Rhizoma Alismatis 2 gram Cortex et Radix Polygalae (processed) 2 gram Flos Chrysanthemis 2 gram Fructus Cnidiis 2 grams
Rhizoma dioscoreae 2 is restrained Radix Aconiti Lateralis Preparata 2 gram Folium Pyrrosiaes (unhairing) 2 gram Radix Rehmanniae Preparata 2 grams
Herba Cistanches 2 gram Cortex Cinnamomi matchmakers 2 gram Radix Codonopsis 2 grams
Method: add 10,000 3 thousand 5 one hundred milliliters in water
Soak half an hour above (warm water), 121 ℃-135 ℃ of device temperature controls, pressure control 0.1MPa-0.2MPa allows medical material abundant Peng in water expand.(the protected monitoring of pressure 0.3-1MPa and National Quality ﹠ Technology Inspection Bureau's special equipment monitoring).
Example 2
Prescription:
8 kilograms of 11 kilograms of Sichuan Herba Dendrobiis of 11 kilograms of mica powders of 11 kilograms of Stalactitums of Poria
8 kilograms of 8 kilograms of Radix Dipsaci of 11 kilograms of Semen Cuscutae of 8 kilograms of Semen Platycladi of Rhizoma Acori Graminei
8 kilograms of 8 kilograms of Fructus Schisandrae Chinensis of 11 kilograms of Radix Achyranthis Bidentataes of 8 kilograms of Radix Asparagi of the Cortex Eucommiae
8 kilograms of 8 kilograms of Fructus Cnidiis of 8 kilograms of Flos Chrysanthemis of 8 kilograms of Cortex et Radix Polygalae (processed) of Rhizoma Alismatis
8 kilograms of 8 kilograms of Radix Rehmanniae Preparata of Rhizoma dioscoreae 8 kilograms of Folium Pyrrosiaes of 8 kilograms of Radix Aconiti Lateralis Preparata (unhairing)
8 kilograms of 8 kilograms of Radix Codonopsis of 8 kilograms of Cortex Cinnamomi matchmakers of Herba Cistanches
Method; With example 1
Example 3
Prescription
8 tons of 11 tons of Sichuan Herba Dendrobiis of 11 tons of mica powders of 11 tons of Stalactitums of Poria
8 tons of 8 tons of Radix Dipsaci of 11 tons of Semen Cuscutae of 8 tons of Semen Platycladi of Rhizoma Acori Graminei
8 tons of 8 tons of Fructus Schisandrae Chinensis of 11 tons of Radix Achyranthis Bidentataes of 8 tons of Radix Asparagi of the Cortex Eucommiae
8 tons of 8 tons of Fructus Cnidiis of 8 tons of Flos Chrysanthemis of 8 tons of Cortex et Radix Polygalae (processed) of Rhizoma Alismatis
8 tons of 8 tons of Radix Rehmanniae Preparata of Rhizoma dioscoreae 8 tons of Folium Pyrrosiaes of 8 tons of Radix Aconiti Lateralis Preparata (unhairing)
8 tons of 8 tons of Radix Codonopsis of 8 tons of Cortex Cinnamomi matchmakers of Herba Cistanches
Method: with example 1.
Preparation method: divided for three steps
One, preparation:
1, open the machine for decocting Chinese traditional herb medicines loam cake, clean one time, comprise that bar looks into cleaning valve, air relief valve and medicinal liquid bleeder (bleeder valve).And cleaning valve, medicinal liquid bleeder and air relief valve closed.Add about clear water 4000m liter.
And close lid.Lock or screw handle.
2, bar is looked into and is led the medicinal liquid flexible pipe and should there be loosening phenomenon in the packer interface.
3, plug in, open heater switch, temperature is controlled at 115-127 ℃ of clear water that causes the inside and boils, and plays preheating and disinfective action.
4, open the packer on and off switch during decocting machine temperature to 90 ℃, regulate hot pressing wheel temperature turn-knob, be set in 110-125 ℃ and can pack after ten minutes.The about 115-121 of temperature ℃ of decocting machine at this moment.Close the decocting machine heater switch.
5, transfer air relief valve and relief valve, whether have steam to pass through, be safety inspection.
6, open pressure release valve, decontamination duct, clear water is managed in the fluid reservoir with steam, opens liquid storage discharge liquid switch, allows hot water come in and emit.Regulate flow control valve controlling packet loading amount.Open the packing switch, hot water also comes out from the packing pipeline, pack five bags automatically after.Reach pipeline disinfectant purpose, close packer packing switch.
7, open air relief valve and cleaning valve, and check whether Pressure gauge gets back to zero.
8, loosen and unscrew handle, open loam cake and prepare to decoct and use.
9, close air relief valve, press valve and cleaning valve.
Two, decoct:
1, compound poria cocos is put in the bag of boiling medicine, tied.Put into and soak half an hour in the suitable containers and put in the decocting machine pot after above, add the 800-1000 ml water again.In 60 packings, 30 day course of treatment and 140-180 milliliter are example.Adding water (connect and soak water interior) altogether is 1.3 ten thousand milliliters to 20,000 milliliters.
2, close pot cover, pressure ram and be rotated counterclockwise height, screw set lever.The order that screws locking is that the diagonal angle intersection screws and locks.
3, turn on the power switch, design temperature is that 115-127 ℃, pressure 0.1MPa, the machine that boils of boiling medicine begin automatic work, and this moment, relay indicating light be red shinny, and Pressure gauge is designated as zero.
4, when machine works arrives design temperature, can stop heating, autostop, relay indicating light are green, pressure rises synchronously gradually simultaneously, arrival authorized pressure, powered-down switch.
5, insulation is 10 minutes, allows its gas that a fully process of reaction is arranged.
6, after 10 minutes, put medicinal liquid again and press the about 500-800 milliliter of valve, towards the pigging road, when liquid storage cylinder effluent does not have, close liquid storage cylinder jar and flow out switch, open again and press valve, along pin ground rotation pressure ram wheel, the full liquid that is immersed in the medical material tissue is entered in the fluid reservoir with pressing pipeline simultaneously.
7, after discharging end through medicinal liquid, close medicinal liquid and press valve, open air relief valve and cleaning valve, residual steam is drained, Pressure gauge is grouped into zero.Rotate in the counterclockwise the extruding handwheel then, make platen get back to a high position, unclamp again and lock the handle that screws, open cover, take out the medicinal residues bag, in the flushing pot.
Three, packing:
1, opens the packing switch, carry out packing.
2, adjustable control valve, the controlling packet loading amount.
3, open to add and compress switch, be filled into 140ml or 180 milliliters, adding compresses switch closes.
4, the shunt volume switch is opened simultaneously, and medicinal liquid is promptly packed automatically.
Compound poria cocos preparation and preparation method are also the same to 150,000 3 thousand milliliters method for making.
Claims (3)
1. Chinese medicine compound poria cocos preparation for the treatment of hepatitis is characterized in that said preparation made by 23 flavor raw material of Chinese medicine of following weight percent:
Poria 3-11 Stalactitum 3-11 mica powder 3-11 Sichuan Herba Dendrobii 2-8
Rhizoma Acori Graminei 2-8 Semen Platycladi 3-11 Semen Cuscutae 2-8 Radix Dipsaci 2-8
The accurate Radix Achyranthis Bidentatae 2-8 of Cortex Eucommiae 2-8 Radix Asparagi 2-8 Fructus Schisandrae Chinensis 2-8
Rhizoma Alismatis 2-8 Cortex et Radix Polygalae (processed) 2-8 Flos Chrysanthemi 2-8 Fructus Cnidii 2-8
Rhizoma dioscoreae 2-8 Radix Aconiti Lateralis Preparata 2-8 Folium Pyrrosiae unhairing 2-8 Radix Rehmanniae Preparata 2-8
Herba Cistanches 2-8 Cortex Cinnamomi 2-8 Radix Codonopsis 2-8.
2. a kind of Chinese medicine compound poria cocos preparation for the treatment of hepatitis according to claim 1 is characterized in that said preparation comprises oral granule electuary, tablet, pill, powder, soft extract, colloid, syrup, mixture, drop pill, capsule, medicated wine, fluid extract or extractum; Or injection; Or externally applied ointment, rubber-emplastrum, ointment, distillate medicinal water, liniment, lozenge or suppository.
3. a kind of preparation method for the treatment of the Chinese medicine compound poria cocos preparation of hepatitis as claimed in claim 1, it is characterized in that this method is to get the clean Chinese medicine of respectively distinguishing the flavor of, put into the reactor of two cover heating and voltage adjusting device, add the water that 0.6-6 doubly measures, soak half an hour, then under 175-115 ℃ temperature and 0.1Mpa-0.2Mpa pressure, decocted 0.5-0.75 hour, decoct and finish, continue insulation ten minutes, emit medicinal liquid, send into that the direct bag distribution packaging of packer becomes oral liquid or, add adjuvant and make various preparations by the medicine routine fashion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2005100287375A CN1911400B (en) | 2005-08-12 | 2005-08-12 | Compound poria cocos preparation, and its preparation method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2005100287375A CN1911400B (en) | 2005-08-12 | 2005-08-12 | Compound poria cocos preparation, and its preparation method |
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| Publication Number | Publication Date |
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| CN1911400A CN1911400A (en) | 2007-02-14 |
| CN1911400B true CN1911400B (en) | 2010-04-14 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2005100287375A Expired - Fee Related CN1911400B (en) | 2005-08-12 | 2005-08-12 | Compound poria cocos preparation, and its preparation method |
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| CN105560819A (en) * | 2016-02-19 | 2016-05-11 | 南通蛇类治疗研究所 | Selenium and germanium enrichment cancer prevention traditional Chinese medicine ancient prescription nano micro capsule beverage |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1160559A (en) * | 1996-11-30 | 1997-10-01 | 李泽良 | Hepatitis B curing toxin-dissipating pill |
| CN1182610A (en) * | 1997-08-09 | 1998-05-27 | 迟经惠 | Medicine for treating heptitis A and B |
| CN1562160A (en) * | 2004-04-21 | 2005-01-12 | 金海清 | Composite medicine for treating hepatitis B complication |
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2005
- 2005-08-12 CN CN2005100287375A patent/CN1911400B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1160559A (en) * | 1996-11-30 | 1997-10-01 | 李泽良 | Hepatitis B curing toxin-dissipating pill |
| CN1182610A (en) * | 1997-08-09 | 1998-05-27 | 迟经惠 | Medicine for treating heptitis A and B |
| CN1562160A (en) * | 2004-04-21 | 2005-01-12 | 金海清 | Composite medicine for treating hepatitis B complication |
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| Publication number | Publication date |
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| CN1911400A (en) | 2007-02-14 |
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