CN101357182B - Medicine containing dark plum for treating diabetes and preparation method thereof - Google Patents
Medicine containing dark plum for treating diabetes and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a medicine containing dark plum and used for treating diabetes and a preparation method thereof. The medicine is made by the following method: (1) medicinal materials are selected, and the medicinal materials comprise the following crude drugs by weight portions: 5-40 portions of trichosanthes root, 10-30 portions of Bupleurum root, 3-15 portions of fruit of immature bitter orange, 1-6 portions of Chinese rhubarb, 1-12 portions of pinellia tuber, 3-15 portions of baikal skullcap root, 1-12 portions of Chinese goldthread, 3-15 portions of white peony root and 5-20 portions of dark plum; (2) The baikal skullcap root is extracted by water to obtain an extracting solution, the pH value of which is adjusted, and the extracting solution is treated by heat preservation and standing and filtered to obtain a precipitate, which is washed by water, dried, smashed and sieved to obtain dry extract powder of the baikal skullcap root; (3) the Chinese goldthread is extracted by ethanol to obtain an extracting solution, which is filtered to obtain a filtrate, the ethanol is recovered, the pH value of the filtrate is adjusted, and the filtrate is refrigerated and filtrate to obtain a precipitate, which is washed by water, dried, smashed and sieved to obtain dry extract powder of the Chinese goldthread; (4) the other medicinal materials are extracted by water to obtain an extracting solution, which is condensed, precipitated in ethanol and filtered to obtain a precipitate, the ethanol is recovered, and the precipitate is dried, smashed and sieved to obtain dry extract powder; and (5) three types of dry extract powders are evenly mixed and added with an adjuvant to be made into a pharmaceutically acceptable dosage form. The medicinal materials of the medicine can be further added with hawthorn fruit.
Description
Technical field
The present invention relates to a kind of medicine, be specifically related to a kind of medicine for the treatment of diabetes and preparation method thereof.
Background technology
Diabetes are the lifelong diseases of a kind of chronic progressive external that caused by sugar, protein and fat metabolic disturbance in the body, and its characteristic shows as hyperglycemia and glycosuria.This disease will cause heart and renal complication, blind and amputation.From observing clinically, the sickness rate of diabetes is being ascendant trend year by year in recent years.At present, the whole world has 1.5 hundred million diabeticss approximately, and the present diabetes number of China surpasses 4,000 ten thousand.In diabetes cases, minority is insulin dependent diabetes mellitus (IDDM) (an I type), and great majority are non-insulin-dependent diabetes mellitus (II type).Most diabetics need be taken medicine all the life.
Treating diabetes is still based on chemical synthetic drug, as sulfonamides, biguanides, glucosidase inhibitor, Lie Nai and euglycemic agent etc. at present.But it is all bigger that these medicines are taken side effect for a long time.
Chinese medicine has long history aspect the diabetes preventing and treating, and the practice through several thousand has accumulated a large amount of invaluable experiences, has formed the unique academic system.The Chinese medicine ancient books and records have been put down in writing the Chinese medicine that much has the blood sugar lowering curative effect, as Rhizoma Alismatis, the Rhizoma Anemarrhenae, Radix Panacis Quinquefolii, Radix Puerariae, Radix Rehmanniae, pollen etc.Traditional TCM treatment of diabetes is to carry out the three types of diabetes opinion according to clinical symptoms to control.But there is not good treatment way in early days at impaired glucose tolerance phase and onset diabetes.
Treatment is with the dissipating depression of QI clearing stomach, nourishing YIN to lower pathogenic fire, and purging FU-organs rushes down turbid.
The position head of this disease blames in the liver stomach, and accumulateing in hot and suffocating is the pathologic basis of diabetes, " soothing the stagnant liver ", " dampness accumulated in the spleen should be removed ", so when to dredge, promptly " must lie prostrate it and lead, and earlier its because of ".The quick clever dissipating depression of QI clearing stomach of sugar, nourishing YIN to lower pathogenic fire, purging FU-organs rushes down turbid, and treating both the principal and secondary aspects of a disease is hot and suffocating both clear, then the cloudy runback of gas." Standards of Diagnosis and Treatment diseases due to endogenous heat of ZANG FU organs " cloud: " road is loose and do not tie, body fluid is given birth to and not withered, QI and blood and and not puckery, and then disease is controlled oneself.”
The inventor is a theoretical foundation with the traditional Chinese medical science " hot and suffocating " theory, discovers that the compositions of being made up of medical materials such as Radix Trichosanthis, Radix Bupleuri, Fructus Aurantii Immaturus, Radix Et Rhizoma Rhei, the Rhizoma Pinelliae, Radix Scutellariae, Rhizoma Coptidis, the Radix Paeoniae Alba, Fructus Mumes has good therapeutical effect to diabetes.But, lost a large amount of water miscible effective ingredient by the extract that traditional pure extracting method obtains; In the leaching process, some medical material interacts; Not only yield is low, and content of effective is very little, so dosage is very big, corresponding side effect also can increase.
Summary of the invention
The object of the present invention is to provide a kind of medicine for the treatment of diabetes, solved the problems referred to above.Adopt following method to be prepared from:
(1) material of getting it filled, described medical material contains the raw medicinal herbs of following weight portion: Radix Trichosanthis 5-40 part, Radix Bupleuri 10-30 part, Fructus Aurantii Immaturus 3-15 part, Radix Et Rhizoma Rhei 1-6 part, Rhizoma Pinelliae 1-12 part, Radix Scutellariae 3-15 part, Rhizoma Coptidis 1-12 part, Radix Paeoniae Alba 3-15 part, Fructus Mume 5-20 part;
(2) Radix Scutellariae adds the water reflux, extract,, merge extractive liquid,, adjust pH to 1.5～2.0; Insulation is left standstill, and filters, and precipitation washes pH value to 5～6 with water, and drying gets Radix Scutellariae extract dry powder;
(3) Rhizoma Coptidis adds alcohol reflux, and merge extractive liquid, filters, and reclaims ethanol to not having alcohol flavor, adjust pH to 1～2; Cold preservation is spent the night, and filters, and precipitation washes pH value to 5～6 with water, and drying gets Rhizoma Coptidis extract dry powder;
(4) other medical materials add the water reflux, extract,, and extracting solution merges, and concentrate, and cool, and add 95% ethanol, and making determining alcohol is 70%; Leave standstill, filter, reclaim ethanol; Drying gets extract dry powder;
(5) get three kinds of extract dry powder, mix homogeneously; Add adjuvant and make the dosage form of accepting on the pharmaceutics.
In the step (2), preferred reflux, extract, twice adds the water of 10 times of its weight, each 1 hour at every turn.Holding temperature is preferably 75-85 ℃, more preferably 80 ℃.
In the step (3), preferred reflux, extract, twice adds the ethanol of 10 times of its weight, each 2 hours at every turn.Concentration of alcohol is preferably 70-85%, and more preferably 75%.
In step (2) and the step (3), the pH regulator agent is preferably concentrated hydrochloric acid.
In the step (4), preferably reflux, extract, is 2 times, adds the water of 10 times of its weight, each 1 hour at every turn.Preferably be concentrated into relative density=1.03～1.07, more preferably relative density=1.05.Preferably reclaim ethanol to relative density=1.25～1.35, more preferably relative density=1.30.
Described medicine, the weight ratio of each raw medicinal herbs is preferably: 9 parts of Radix Trichosanthis, 12 parts of Radix Bupleuri, 9 parts of Fructus Aurantii Immaturuss, 3 parts of Radix Et Rhizoma Rhei, 6 parts of the Rhizoma Pinelliaes, 9 parts of Radix Scutellariaes, 6 parts of Rhizoma Coptidis, 9 parts of the Radix Paeoniae Albas, 9 parts of Fructus Mumes.
Better, the present invention can also add Fructus Crataegi on the basis of described medicine, and this is because the Fructus Crataegi sour and sweet drugs can transforme into YIN, both can be in case the hot too impairment of YIN of loosing, but picric acid system is sweet again.The heat clearing away of compatibility dissipating depression of QI has better curative effect.The weight portion of each raw medicinal herbs is: Radix Trichosanthis 5-40 part, Radix Bupleuri 10-30 part, Fructus Aurantii Immaturus 3-15 part, Radix Et Rhizoma Rhei 1-6 part, Rhizoma Pinelliae 1-12 part, Radix Scutellariae 3-15 part, Rhizoma Coptidis 1-12 part, Radix Paeoniae Alba 3-15 part, Fructus Mume 5-20 part, Fructus Crataegi 3-15 part.
Be preferably: Radix Trichosanthis 10-30 part, Radix Bupleuri 10-30 part, Fructus Aurantii Immaturus 3-15 part, Radix Et Rhizoma Rhei 1-6 part, Rhizoma Pinelliae 1-12 part, Radix Scutellariae 3-15 part, Rhizoma Coptidis 1-12 part, Radix Paeoniae Alba 3-15 part, Fructus Mume 5-20 part, Fructus Crataegi 3-15 part.
More preferably: 30 parts of Radix Trichosanthis, 12 parts of Radix Bupleuri, 9 parts of Fructus Aurantii Immaturuss, 3 parts of Radix Et Rhizoma Rhei, 6 parts of the Rhizoma Pinelliaes, 9 parts of Radix Scutellariaes, 6 parts of Rhizoma Coptidis, 9 parts of the Radix Paeoniae Albas, 15 parts of Fructus Mumes, 9 parts of Fructus Crataegis;
Perhaps 15 parts of Radix Trichosanthis, 12 parts of Radix Bupleuri, 9 parts of Fructus Aurantii Immaturuss, 3 parts of Radix Et Rhizoma Rhei, 6 parts of the Rhizoma Pinelliaes, 9 parts of Radix Scutellariaes, 6 parts of Rhizoma Coptidis, 9 parts of the Radix Paeoniae Albas, 15 parts of Fructus Mumes, 9 parts of Fructus Crataegis.
Radix Scutellariae, Rhizoma Coptidis and other medical materials are extracted separately respectively, and according to himself character respectively water carry or alcohol extraction, regulate pH value, content of effective obviously improves in the Chinese medicine composition of the present invention, the content of impurity significantly reduces, thereby has reduced the dosage of administration.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into the preparation of any routine.For example the above-mentioned raw materials medicine is ground into powder and takes after mixing it with water, or make tablet or capsule oral, perhaps make injection etc.But these can not be used to limit protection scope of the present invention.
The specific embodiment
Further specify medicine of the present invention and beneficial effect thereof below by embodiment and test example, but not as limitation of the present invention.
The preparation of embodiment 1 capsule of the present invention
Radix Trichosanthis 750g, Radix Bupleuri 1500g, Fructus Aurantii Immaturus 450g, Radix Et Rhizoma Rhei 150g, Rhizoma Pinelliae 150g, Radix Scutellariae 450g, Rhizoma Coptidis 150g, Radix Paeoniae Alba 450g, Fructus Mume 750g
Radix Scutellariae adds the water of 10 times of its weight, reflux, extract, twice, each 1 hour; Merge extractive liquid, adds concentrated hydrochloric acid adjust pH to 1.5～2.0,75 ℃ insulation 1 hour, leaves standstill, and filters; Precipitation washes pH value to 5～6 with water, drying, and broken mistake 80 mesh sieves of dried cream powder get Radix Scutellariae extract.Rhizoma Coptidis adds 70% alcohol reflux twice of 10 times of its weight, each 2 hours; Merge extractive liquid, filters, and reclaims ethanol to there not being the alcohol flavor, adds concentrated hydrochloric acid adjust pH to 1～2, and cold preservation is spent the night, and filters; Precipitation washes pH value to 5～6 with water, drying, and broken mistake 80 mesh sieves of dried cream powder get Rhizoma Coptidis extract.All the other 7 flavor medical materials add the water reflux, extract, 2 times of 10 times of its weight, each 1 hour; The extracting solution merging is evaporated to relative density=1.03, cools, and adds 95% ethanol, and making determining alcohol is 70%; Leave standstill, filter, reclaim ethanol to relative density=1.25, drying, broken mistake 80 mesh sieves of dried cream powder.
Get three kinds of extract dry powder, mix homogeneously adds lactose and makes capsule.
The preparation of embodiment 2 tablets of the present invention
Radix Trichosanthis 1200g, Radix Bupleuri 900g, Fructus Aurantii Immaturus 450g, Radix Et Rhizoma Rhei 180g, Rhizoma Pinelliae 360g, Radix Scutellariae 450g, Rhizoma Coptidis 360g, Radix Paeoniae Alba 450g, Fructus Mume 600g
Radix Scutellariae adds the water of 10 times of its weight, reflux, extract, twice, each 1 hour; Merge extractive liquid, adds concentrated hydrochloric acid adjust pH to 1.5～2.0,85 ℃ insulation 1 hour, leaves standstill, and filters; Precipitation washes pH value to 5～6 with water, drying, and broken mistake 80 mesh sieves of dried cream powder get Radix Scutellariae extract.Rhizoma Coptidis adds 85% alcohol reflux twice of 10 times of its weight, each 2 hours; Merge extractive liquid, filters, and reclaims ethanol to there not being the alcohol flavor, adds concentrated hydrochloric acid adjust pH to 1～2, and cold preservation is spent the night, and filters; Precipitation washes pH value to 5～6 with water, drying, and broken mistake 80 mesh sieves of dried cream powder get Rhizoma Coptidis extract.All the other 7 flavor medical materials add the water reflux, extract, 2 times of 10 times of its weight, each 1 hour; The extracting solution merging is evaporated to relative density=1.07, cools, and adds 95% ethanol, and making determining alcohol is 70%; Leave standstill, filter, reclaim ethanol to relative density=1.35, drying, broken mistake 80 mesh sieves of dried cream powder.
Get three kinds of extract dry powder, mix homogeneously adds starch and makes capsule.
The preparation of embodiment 3 medicine concentrated pills of the present invention
Radix Trichosanthis 630g Radix Bupleuri 840g Fructus Aurantii Immaturus 630g Radix Et Rhizoma Rhei 210g Rhizoma Pinelliae 420g Radix Scutellariae 630g Rhizoma Coptidis 420g Radix Paeoniae Alba 630g Fructus Mume 630g
Radix Scutellariae adds the water of 10 times of its weight, reflux, extract, twice, each 1 hour; Merge extractive liquid, adds concentrated hydrochloric acid adjust pH to 1.5～2.0,80 ℃ insulation 1 hour, leaves standstill, and filters; Precipitation washes pH value to 5～6 with water, drying, and broken mistake 80 mesh sieves of dried cream powder get Radix Scutellariae extract.Rhizoma Coptidis adds 75% alcohol reflux twice of 10 times of its weight, each 2 hours; Merge extractive liquid, filters, and reclaims ethanol to there not being the alcohol flavor, adds concentrated hydrochloric acid adjust pH to 1～2, and cold preservation is spent the night, and filters; Precipitation washes pH value to 5～6 with water, drying, and broken mistake 80 mesh sieves of dried cream powder get Rhizoma Coptidis extract.All the other 7 flavor medical materials add the water reflux, extract, 2 times of 10 times of its weight, each 1 hour; The extracting solution merging is evaporated to relative density=1.05, cools, and adds 95% ethanol, and making determining alcohol is 70%; Leave standstill, filter, reclaim ethanol to relative density=1.30, drying, broken mistake 80 mesh sieves of dried cream powder.
Get three kinds of extract dry powder, mix homogeneously adds microcrystalline Cellulose and makes concentrated pill.
The preparation of embodiment 4 capsules of the present invention
Radix Trichosanthis 750g, Radix Bupleuri 1500g, Fructus Aurantii Immaturus 450g, Radix Et Rhizoma Rhei 150g, Rhizoma Pinelliae 150g, Radix Scutellariae 450g, Rhizoma Coptidis 150g, Radix Paeoniae Alba 450g, Fructus Mume 750g, Fructus Crataegi 450g
Radix Scutellariae adds the water of 10 times of its weight, reflux, extract, twice, each 1 hour; Merge extractive liquid, adds concentrated hydrochloric acid adjust pH to 1.5～2.0,75 ℃ insulation 1 hour, leaves standstill, and filters; Precipitation washes pH value to 5～6 with water, drying, and broken mistake 80 mesh sieves of dried cream powder get Radix Scutellariae extract.Rhizoma Coptidis adds 70% alcohol reflux twice of 10 times of its weight, each 2 hours; Merge extractive liquid, filters, and reclaims ethanol to there not being the alcohol flavor, adds concentrated hydrochloric acid adjust pH to 1～2, and cold preservation is spent the night, and filters; Precipitation washes pH value to 5～6 with water, drying, and broken mistake 80 mesh sieves of dried cream powder get Rhizoma Coptidis extract.All the other 8 flavor medical materials add the water reflux, extract, 2 times of 10 times of its weight, each 1 hour; The extracting solution merging is evaporated to relative density=1.07, cools, and adds 95% ethanol, and making determining alcohol is 70%; Leave standstill, filter, reclaim ethanol to relative density=1.25, drying, broken mistake 80 mesh sieves of dried cream powder.
Get three kinds of extract dry powder, mix homogeneously adds lactose and makes capsule.
The preparation of embodiment 5 capsules of the present invention
Radix Trichosanthis 1200g, Radix Bupleuri 900g, Fructus Aurantii Immaturus 450g, Radix Et Rhizoma Rhei 180g, Rhizoma Pinelliae 360g, Radix Scutellariae 450g, Rhizoma Coptidis 360g, Radix Paeoniae Alba 450g, Fructus Mume 600g, Fructus Crataegi 450g
Radix Scutellariae adds the water of 10 times of its weight, reflux, extract, twice, each 1 hour; Merge extractive liquid, adds concentrated hydrochloric acid adjust pH to 1.5～2.0,80 ℃ insulation 1 hour, leaves standstill, and filters; Precipitation washes pH value to 5～6 with water, drying, and broken mistake 80 mesh sieves of dried cream powder get Radix Scutellariae extract.Rhizoma Coptidis adds 70% alcohol reflux twice of 10 times of its weight, each 2 hours; Merge extractive liquid, filters, and reclaims ethanol to there not being the alcohol flavor, adds concentrated hydrochloric acid adjust pH to 1～2, and cold preservation is spent the night, and filters; Precipitation washes pH value to 5～6 with water, drying, and broken mistake 80 mesh sieves of dried cream powder get Rhizoma Coptidis extract.All the other 8 flavor medical materials add the water reflux, extract, 2 times of 10 times of its weight, each 1 hour; The extracting solution merging is evaporated to relative density=1.03, cools, and adds 95% ethanol, and making determining alcohol is 70%; Leave standstill, filter, reclaim ethanol to relative density=1.35, drying, broken mistake 80 mesh sieves of dried cream powder.
Get three kinds of extract dry powder, mix homogeneously adds lactose and makes capsule.
The preparation of embodiment 6 medicine concentrated pills of the present invention
Radix Trichosanthis 833g Radix Bupleuri 667g Fructus Aurantii Immaturus 500g Radix Et Rhizoma Rhei 167g Rhizoma Pinelliae 333g Radix Scutellariae 500g Rhizoma Coptidis 333g Radix Paeoniae Alba 500g Fructus Mume 833g Fructus Crataegi 500g
Radix Scutellariae adds the water of 10 times of its weight, reflux, extract, twice, each 1 hour; Merge extractive liquid, adds concentrated hydrochloric acid adjust pH to 1.5～2.0,80 ℃ insulation 1 hour, leaves standstill, and filters; Precipitation washes pH value to 5～6 with water, drying, and broken mistake 80 mesh sieves of dried cream powder get Radix Scutellariae extract.Rhizoma Coptidis adds 75% alcohol reflux twice of 10 times of its weight, each 2 hours; Merge extractive liquid, filters, and reclaims ethanol to there not being the alcohol flavor, adds concentrated hydrochloric acid adjust pH to 1～2, and cold preservation is spent the night, and filters; Precipitation washes pH value to 5～6 with water, drying, and broken mistake 80 mesh sieves of dried cream powder get Rhizoma Coptidis extract.All the other 8 flavor medical materials add the water reflux, extract, 2 times of 10 times of its weight, each 1 hour; The extracting solution merging is evaporated to relative density=1.05, cools, and adds 95% ethanol, and making determining alcohol is 70%; Leave standstill, filter, reclaim ethanol to relative density=1.30, drying, broken mistake 80 mesh sieves of dried cream powder.
Get three kinds of extract dry powder, mix homogeneously adds microcrystalline Cellulose and makes concentrated pill.
The preparation of embodiment 7 medicinal tablets of the present invention
Radix Trichosanthis 500g, Radix Bupleuri 750g, Fructus Aurantii Immaturus 500g, Radix Et Rhizoma Rhei 250g, Rhizoma Pinelliae 500g part, Radix Scutellariae 500g, Rhizoma Coptidis 500g, Radix Paeoniae Alba 500g, Fructus Mume 500g, Fructus Crataegi 500g
Radix Scutellariae adds the water of 10 times of its weight, reflux, extract, twice, each 1 hour; Merge extractive liquid, adds concentrated hydrochloric acid adjust pH to 1.5～2.0,85 ℃ insulation 1 hour, leaves standstill, and filters; Precipitation washes pH value to 5～6 with water, drying, and broken mistake 80 mesh sieves of dried cream powder get Radix Scutellariae extract.Rhizoma Coptidis adds 85% alcohol reflux twice of 10 times of its weight, each 2 hours; Merge extractive liquid, filters, and reclaims ethanol to there not being the alcohol flavor, adds concentrated hydrochloric acid adjust pH to 1～2, and cold preservation is spent the night, and filters; Precipitation washes pH value to 5～6 with water, drying, and broken mistake 80 mesh sieves of dried cream powder get Rhizoma Coptidis extract.All the other 8 flavor medical materials add the water reflux, extract, 2 times of 10 times of its weight, each 1 hour; The extracting solution merging is evaporated to relative density=1.05, cools, and adds 95% ethanol, and making determining alcohol is 70%; Leave standstill, filter, reclaim ethanol to relative density=1.25, drying, broken mistake 80 mesh sieves of dried cream powder.
Get three kinds of extract dry powder, mix homogeneously adds dextrin and makes tablet.
The preparation of embodiment 8 medicine capsules of the present invention
Radix Trichosanthis 1200g, Radix Bupleuri 800g, Fructus Aurantii Immaturus 600g, Radix Et Rhizoma Rhei 200g, Rhizoma Pinelliae 400g, Radix Scutellariae 400g, Rhizoma Coptidis 200g, Radix Paeoniae Alba 400g, Fructus Mume 400g, Fructus Crataegi 400g
Radix Scutellariae adds the water of 10 times of its weight, reflux, extract, twice, each 1 hour; Merge extractive liquid, adds concentrated hydrochloric acid adjust pH to 1.5～2.0,75 ℃ insulation 1 hour, leaves standstill, and filters; Precipitation washes pH value to 5～6 with water, drying, and broken mistake 80 mesh sieves of dried cream powder get Radix Scutellariae extract.Rhizoma Coptidis adds 75% alcohol reflux twice of 10 times of its weight, each 2 hours; Merge extractive liquid, filters, and reclaims ethanol to there not being the alcohol flavor, adds concentrated hydrochloric acid adjust pH to 1～2, and cold preservation is spent the night, and filters; Precipitation washes pH value to 5～6 with water, drying, and broken mistake 80 mesh sieves of dried cream powder get Rhizoma Coptidis extract.All the other 8 flavor medical materials add the water reflux, extract, 2 times of 10 times of its weight, each 1 hour; The extracting solution merging is evaporated to relative density=1.05, cools, and adds 95% ethanol, and making determining alcohol is 70%; Leave standstill, filter, reclaim ethanol to relative density=1.35, drying, broken mistake 80 mesh sieves of dried cream powder.
Get three kinds of extract dry powder, mix homogeneously adds lactose and makes capsule.
The preparation of embodiment 9 medicine capsules of the present invention
Radix Trichosanthis 1000g, Radix Bupleuri 600g, Fructus Aurantii Immaturus 600g, Radix Et Rhizoma Rhei 250g, Rhizoma Pinelliae 300g, Radix Scutellariae 500g, Rhizoma Coptidis 300g, Radix Paeoniae Alba 500g, Fructus Mume 500g, Fructus Crataegi 300g
Radix Scutellariae adds the water of 10 times of its weight, reflux, extract, twice, each 1 hour; Merge extractive liquid, adds concentrated hydrochloric acid adjust pH to 1.5～2.0,80 ℃ insulation 1 hour, leaves standstill, and filters; Precipitation washes pH value to 5～6 with water, drying, and broken mistake 80 mesh sieves of dried cream powder get Radix Scutellariae extract.Rhizoma Coptidis adds 80% alcohol reflux twice of 10 times of its weight, each 2 hours; Merge extractive liquid, filters, and reclaims ethanol to there not being the alcohol flavor, adds concentrated hydrochloric acid adjust pH to 1～2, and cold preservation is spent the night, and filters; Precipitation washes pH value to 5～6 with water, drying, and broken mistake 80 mesh sieves of dried cream powder get Rhizoma Coptidis extract.All the other 8 flavor medical materials add the water reflux, extract, 2 times of 10 times of its weight, each 1 hour; The extracting solution merging is evaporated to relative density=1.05, cools, and adds 95% ethanol, and making determining alcohol is 70%; Leave standstill, filter, reclaim ethanol to relative density=1.30, drying, broken mistake 80 mesh sieves of dried cream powder.
Get three kinds of extract dry powder, mix homogeneously adds lactose and makes capsule.
Test example 1
1) laboratory animal:
SPF level male SD rat, body weight 200-220g.
2) main agents and medicine:
Streptozotocin (Streptozotocin, STZ): U.S. sigma company, lot number 024K1211;
Steady milli type blood glucose meter (One-Touch Ultra): U.S. Lifescan company, number of registration 20032400735;
Anhydrous citric acid (C
6H
8O
7.H
2O): Tianjin chemical reagent one factory, lot number 011121;
Sodium citrate (Na
3C
6H
5O
7.2H
2O): Tianjin chemical reagent one factory, lot number 011219;
Metformin: the 250mg/ sheet, Tianjin Pacific Pharmaceutical Co., Ltd. produces, lot number 040121;
The difference prescription group medicine of test example is respectively the extract powder according to embodiment 3, embodiment 8 and embodiment 9 preparations, and numbering is respectively TL-1, TL-2 and TL-3.
3) model preparation:
The SD rat adapts to the back fasting overnight of 1 week, and through lumbar injection STZ65mg/Kg (0.1mmol/l, PH4.4 citrate buffer solution are made the solution of 2% (W/V)), the tail vein is got blood to survey blood glucose 〉=16.7mmol/L be the modeling success after 3 days.
4) medication and observation index:
The diabetes rat of Cheng Mo is divided into model group, metformin 125mg/Kg group and different prescription groups (crude drug 15.5g/Kg) at random.Adapt to a week, detect gastric infusion behind the blood glucose, once a day, medicine all is mixed with the suspension administration with normal saline, the experimental session drinking-water of all freely ingesting, 15 days experimental periods.Administration the 7th, 14 days, fasting was 2 hours after the administration, and the tail vein is got blood one-touchultra blood glucose meter and measured blood glucose, detected the body weight of rat simultaneously.
5) statistical procedures:
(X ± SD) expression, two group difference significances adopt the t check to experimental data with mean ± standard deviation.
6) result
By table 1 as seen, different prescription groups are when 15.5g/Kg dosage, and administration all made the blood glucose of STZ hyperglycemic rat obviously descend (P＜0.01) after 7,14 days.
Table 1. is respectively organized changes of blood glucose and comparison (X ± SDn=10)
Annotate: compare with matched group
*P＜0.01; Compare with model group
▲P＜0.01
Claims (11)
1. preparation method that is used for the treatment of the medicine of diabetes may further comprise the steps:
(1) material of getting it filled, described medical material contains the raw medicinal herbs of following weight portion: Radix Trichosanthis 5-40 part, Radix Bupleuri 10-30 part, Fructus Aurantii Immaturus 3-15 part, Radix Et Rhizoma Rhei 1-6 part, Rhizoma Pinelliae 1-12 part, Radix Scutellariae 3-15 part, Rhizoma Coptidis 1-12 part, Radix Paeoniae Alba 3-15 part, Fructus Mume 5-20 part;
(2) Radix Scutellariae adds the water reflux, extract,, merge extractive liquid,, adjust pH to 1.5～2.0; Insulation is left standstill, and filters, and precipitation washes pH value to 5～6 with water, and drying gets Radix Scutellariae extract dry powder;
(3) Rhizoma Coptidis adds the alcohol reflux of 70-85%, and merge extractive liquid, filters, and reclaims ethanol to not having alcohol flavor, adjust pH to 1～2; Cold preservation is spent the night, and filters, and precipitation washes pH value to 5～6 with water, and drying gets Rhizoma Coptidis extract dry powder;
(4) other medical materials add the water reflux, extract,, and extracting solution merges, and concentrate, and cool, and add 95% ethanol, and making determining alcohol is 70%; Leave standstill, filter, reclaim ethanol; Drying gets extract dry powder;
(5) get three kinds of extract dry powder, mix homogeneously; Add adjuvant and make the dosage form of accepting on the pharmaceutics.
2. the described preparation method of claim 1 is characterized in that in the step (2), and reflux, extract, twice adds the water of 10 times of its weight, each 1 hour at every turn.
3. the described preparation method of claim 1 is characterized in that in the step (2), holding temperature is 75-85 ℃.
4. the described preparation method of claim 3 is characterized in that in the step (2), holding temperature is 80 ℃.
5. the described preparation method of claim 1 is characterized in that in the step (3), and reflux, extract, twice adds the ethanol of 10 times of its weight, each 2 hours at every turn.
6. the described preparation method of claim 1 is characterized in that the pH regulator agent is a concentrated hydrochloric acid in step (2) and the step (3).
7. the described preparation method of claim 1 is characterized in that in the step (4), and reflux, extract, 2 times adds the water of 10 times of its weight, each 1 hour at every turn.
8. the described preparation method of claim 1 is characterized in that being concentrated into relative density=1.03～1.07 in the step (4).
9. the described preparation method of claim 8 is characterized in that relative density in the step (4)=1.05.
10. the described preparation method of claim 1 is characterized in that in the step (4), reclaims ethanol to relative density=1.25～1.35.
11. the described preparation method of claim 10 is characterized in that relative density in the step (4)=1.30.
Priority Applications (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710058573XA CN101357182B (en) | 2007-08-02 | 2007-08-02 | Medicine containing dark plum for treating diabetes and preparation method thereof |
| MYPI20094878A MY154567A (en) | 2007-08-02 | 2008-07-28 | A pharmaceutical composition for treating diabetes and its process for preparation |
| CA2687492A CA2687492C (en) | 2007-08-02 | 2008-07-28 | A herbal composition, method for preparing the same and use thereof for treating diabetes mellitus |
| AU2008281227A AU2008281227B2 (en) | 2007-08-02 | 2008-07-28 | A pharmaceutical composition for treating diabetes and its process for preparation |
| PCT/CN2008/001383 WO2009015557A1 (en) | 2007-08-02 | 2008-07-28 | A pharmaceutical composition for treating diabetes and its process for preparation |
| BRPI0812792A BRPI0812792B8 (en) | 2007-08-02 | 2008-07-28 | method for preparing a pharmaceutical composition for the treatment of diabetes mellitus and said pharmaceutical composition |
| DK08783574.0T DK2172207T3 (en) | 2007-08-02 | 2008-07-28 | Pharmaceutical composition for the treatment of diabetes and its method of preparation |
| US12/601,236 US8637092B2 (en) | 2007-08-02 | 2008-07-28 | Pharmaceutical composition for treating diabetes and its process for preparation |
| RU2009144878/15A RU2485968C2 (en) | 2007-08-02 | 2008-07-28 | Drug preparation for treating diabetes and method for preparing it |
| NZ581525A NZ581525A (en) | 2007-08-02 | 2008-07-28 | A pharmaceutical composition for treating diabetes and its process for preparation |
| JP2010518477A JP5508264B2 (en) | 2007-08-02 | 2008-07-28 | PHARMACEUTICAL COMPOSITION FOR DIABETES TREATMENT AND METHOD FOR PRODUCING THE SAME |
| KR1020107003490A KR101462984B1 (en) | 2007-08-02 | 2008-07-28 | A pharmaceutical composition for treating diabetes and its process for preparation |
| EP08783574A EP2172207B1 (en) | 2007-08-02 | 2008-07-28 | A pharmaceutical composition for treating diabetes and its process for preparation |
| ARP080103309A AR070306A1 (en) | 2007-08-02 | 2008-07-30 | A PHARMACEUTICAL COMPOSITION TO TREAT MELLITUS DIABETES AND THE METHOD TO PREPARE THE SAME |
| HK10104520.9A HK1138206A1 (en) | 2007-08-02 | 2010-05-10 | A pharmaceutical composition for treating diabetes and its process for preparation |
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| CN200710058573XA CN101357182B (en) | 2007-08-02 | 2007-08-02 | Medicine containing dark plum for treating diabetes and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1376495A (en) * | 2002-01-31 | 2002-10-30 | 刘惠生 | Chinese medicine for treating diabetes and its complication |
| CN1726929A (en) * | 2004-07-30 | 2006-02-01 | 天津天士力制药股份有限公司 | Compsn. of medication for treating diabetes |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1376495A (en) * | 2002-01-31 | 2002-10-30 | 刘惠生 | Chinese medicine for treating diabetes and its complication |
| CN1726929A (en) * | 2004-07-30 | 2006-02-01 | 天津天士力制药股份有限公司 | Compsn. of medication for treating diabetes |
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