CN1899346A - Bighead atractylodes rhizome spine ache tablet - Google Patents
Bighead atractylodes rhizome spine ache tablet Download PDFInfo
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- CN1899346A CN1899346A CN 200610043151 CN200610043151A CN1899346A CN 1899346 A CN1899346 A CN 1899346A CN 200610043151 CN200610043151 CN 200610043151 CN 200610043151 A CN200610043151 A CN 200610043151A CN 1899346 A CN1899346 A CN 1899346A
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- rhizoma atractylodis
- atractylodis macrocephalae
- ache
- spine
- atractylodes rhizome
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Abstract
The present invention relates to medicine preparation, and is especially one Chinese medicine preparation for treating pain in the pack and loin. The Chinese medicine preparation is prepared through soaking white atractylodes rhizome in milk. It has the functions of benefiting Qi, invigorating spleen, eliminating damp, relieving pain, invigorating kidney and strengthening bone, and has high curative effect on pain in the pack and loin caused by lumbar muscle strain.
Description
Technical field
The invention belongs to the pharmaceutical product technical field, particularly is the Chinese medicine preparation of feedstock production with Chinese herbal medicine.
Background technology
Low-back pain is many with muscular strain or joint of vertebral column degeneration, and a kind of neuropathic pain disease that causes.Often with can not endure hardships, the aching and tired pain of lower back, the time heavy when light, the course of disease is longer, Therapeutic Method is few, medical effect is not good enough be feature, and common saying " patient's lumbago, doctor has a headache " is arranged.Make a lot of patients and doctor all feel to be difficult to tackle.Check that lower back does not have deformity, functional activity is restricted, and diseased region has pressure pain point.The X ray examination, visible joint of vertebral column degeneration (hyperosteogeny).
The means of the low-back pain that at present common treatment lumbar muscle strain or joint of vertebral column degeneration cause comprise:
(1) improve blood circulation: utilize methods such as massage, traction, local diathermanous, iontophoresis, ultrashort wave, audio frequency, relieve muscle spasms is improved blood circulation.
(2) pain relieving: to local tenderness point person is arranged, available predniso lone acetate or hydrocortisone acetate 1ml add 1% procaine, 5～10ml and do the pain spot injection, and 5～7 days 1 time, 3～4 times is a course of treatment.
(3) acupuncture and Chinese medicine: acupuncture, cupping have certain curative effect, but alleviating pain, and Chinese medicine is with blood circulation promoting and blood stasis dispelling, liver and kidney tonifying, promoting the flow of QI in the collateral by warming the meridian, bone and muscle strengthening.
(4) pain relieving spasmolytic: aspirin, indometacin, ibuprofen etc. can be used when pain, and life-time service forms dependence or reduction effect easily.
Above-mentioned physical means treatment cycle is generally longer, and Western medicine recurs easily or form dependency.The Chinese medicine proportioning that is adopted is all complicated, and effect is general.
Summary of the invention
The object of the invention provides a kind of medicine for the treatment of the lumbar and back pain that joint of vertebral column lumbar muscle strain or degeneration hyperosteogeny cause.
Motherland's medical science is thought: lumbago diseases is because of being mainly diseases caused by exogenous pathogenic factor, internal injury and tumbling down sprain and contusion.Diseases caused by exogenous pathogenic factor person, a lot of diseases are more anxious, and lumbago is obvious, often with the diseases caused by exogenous pathogenic factor symptom; Interior the wounded, many insidious onsets, waist is ached, and the course of disease is touching, often with the internal organs symptom, is more common in and suffers from a deficiency of the kidney; Tumbling down sprain and contusion person, onset is anxious, and painful area is fixed, and the blood stasis symptom is obvious, often has trauma history to reflect.
Therefore, traditional Chinese medical science angle Therapeutic Principle is generally: treatment for low back pain is when this deficiency and excess of minute mark.Being invaded by exogenous pathogen is true, controls suitable eliminating evil collateral dredging, and according to cold-damp, damp and hot difference gives the diffusing or clear dampness removing heresy of temperature respectively; The wound lumbago is true, controls suitable blood circulation promoting and blood stasis dispelling, and removing obstruction in the collateral to relieve pain is main; Internal injury is caused a disease belongs to void more, and controlling reinforcing kidney and strengthening resistance to be main, takes into account the liver spleen; The double person of opinion of deficiency and excess should distinguish the primary and secondary weight, giving consideration to both the incidental and fundamental.Subtract as " miscellaneous diseases source and course rhinoceros candle " and point out: " suffer from a deficiency of the kidney, it also; Wind, cold, wet, heat, phlegm retention, the stagnation of QI, blood stasis, sprain and contusion, it is marked also.Or from mark, or from this, your nothing is lost it should.”
Lumbago diseases is because of having diseases caused by exogenous pathogenic factor, internal injury, the tumbling down sprain and contusion.Its morbidity is a basis to suffer from a deficiency of the kidney often, and being invaded by exogenous pathogen, tumbling down sprain and contusion are mark.Suffer from a deficiency of the kidney or for insufficiency of kidney-YANG, or be cloudy damage of essence void, the waist mansion is lost and is supported, and belongs to void; Cold-damp, damp and hot, the stagnation of blood stasis passages through which vital energy circulates, QI-blood circulation is not smooth, and is true.Excess syndrome is prolonged and can be caused weakened body resistancely for a long time, and susceptible is evil again causes a disease for deficiency syndrome.Excess syndrome focuses on and eliminating evilly promotes blood circulation actively during treatment, and lumbago due to cold-damp is when the dispelling cold by warming the meridian damp eliminating, and lumbago due to damp-heat is when the clearing away heat-damp and promoting diuresis Shujin, and lumbago due to blood stasis is worked as activating blood circulation to dissipate blood stasis and dredge the collateral.Deficiency syndrome focus on to be set upright, and invigorating the liver and kidney, strong spinal column, spleen invigorating gas are method of treatment commonly used.
Lumbago with the passing of time, simulataneous insufficiency and excessive, treatment should be grasped the specimen deficiency and excess, selects eliminating evil and method reinforcing for use.Generally from the beginning of based on eliminating evil, disease is then given liver and kidney tonifying for a long time, the spleen invigorating reinforcing, or eliminating evil and set upright and usefulness, to reach the purpose of strengthening vital QI to eliminate pathogenic factors.
According to above-mentioned theory, the present invention makes after soaking in milk with the Chinese medicine Rhizoma Atractylodis Macrocephalae.
The present invention makes tablet after also adding starch, sucrose, magnesium stearate.
Preparation technology:
Get about 4000 grams of the Rhizoma Atractylodis Macrocephalae, soaked about 12 hours with fresh milk, 100 mesh sieves were pulverized in oven dry, and it is standby to get 3000 grams, gets the Rhizoma Atractylodis Macrocephalae and remaining Rhizoma Atractylodis Macrocephalae powder again, adds 8 times in water for the first time, extracts 60 minutes; For the second time add 6 times in water, extracted merge extractive liquid, 40 minutes, filter, filtrate concentrating adds equivalent 95% ethanol, stirs, and leaves standstill 12-24 hour, the elimination supernatant, reclaim ethanol, it is standby to be concentrated into the 2000-2200 milligram, gets sucrose again and pulverizes 100 mesh sieves, add starch, Rhizoma Atractylodis Macrocephalae powder mixing crosses 80 mesh sieves and concentrated solution is mixed thoroughly, pelletizing press sheet 20000-21000 sheet, sheet weighs 0.3 gram (every contain Rhizoma Atractylodis Macrocephalae extractum 1.25 gram).
The present invention solely gets the Rhizoma Atractylodis Macrocephalae and is equipped with milk simply with replenishing QI to invigorate the spleen, damp-clearing pain-relieving, again can the tonify deficiency bone strengthening.More than 89%, obvious effective rate is more than 55% to the lumbar and back pain clinical effective rate of lumbar muscle strain.
The specific embodiment:
Raw material and proportioning: the Rhizoma Atractylodis Macrocephalae 25000 grams, fresh milk (consumption milk) 5000 grams, starch 2000 grams, sucrose 1000 grams, magnesium stearate 40 grams.
Preparation technology:
Get about 4000 grams of the Rhizoma Atractylodis Macrocephalae, soaked about 12 hours with fresh milk, 100 mesh sieves were pulverized in oven dry, and it is standby to get 3000 grams, gets the Rhizoma Atractylodis Macrocephalae and remaining Rhizoma Atractylodis Macrocephalae powder again, adds 8 times in water for the first time, extracts 60 minutes; For the second time add 6 times in water, extracted merge extractive liquid, 40 minutes, filter, filtrate concentrating adds equivalent 95% ethanol, stirs, and leaves standstill 12-24 hour, the elimination supernatant, reclaim ethanol, it is standby to be concentrated into the 2000-2200 milligram, gets sucrose again and pulverizes 100 mesh sieves, add starch, Rhizoma Atractylodis Macrocephalae powder mixing crosses 80 mesh sieves and concentrated solution is mixed thoroughly, pelletizing press sheet 20000-21000 sheet, sheet weighs 0.3 gram (every contain Rhizoma Atractylodis Macrocephalae extractum 1.25 gram)
Dosage form: sheet
Function cures mainly: replenishing QI to invigorate the spleen, damp-clearing pain-relieving, low-back pain; Degeneration joint of vertebral column hyperosteogeny.
The clinical summary report
In May, 2003-2004 year June, the applicant adopts bighead atractylodes rhizome spine ache tablet (according to the preparation of the preparation technology described in the file), patients with low-back pain 200 examples that treatment degeneration joint of vertebral column hypertrophy and chronic lumbar muscle strain cause, and compare observation with 46 examples of Western medicine anti-inflammatory analgesic class treatment, now be reported as follows.
1, clinical data
All patients are the out-patient, and 246 routine patients are divided into two groups at random, and 200 people are organized in treatment, wherein male 138 examples, women 62 examples, 19～75 years old age, The median age 46 years old, the course of disease 1 month～24 years.Matched group 46 examples, wherein male 35 examples, women 11 examples, 17～60 years old age, The median age 38.5 years old, the course of disease 1 month～20 years.Two groups of cases compare aspect sex, age, the course of disease, severity extent, and difference does not have significance (P＞0.05), has comparability.
2, Therapeutic Method
2.1 the treatment group, bighead atractylodes rhizome spine ache tablet 6～10g/ time, 3 times on the 1st, with yellow wine or warm water delivery service, 20 days is 1 course of treatment.
2.2 matched group analgesic agent compound chlorzoxazone 0.1g, indometacin 50mg, 3 times on the 1st, the course of treatment is with the treatment group.During treating, all do not use other medicines, plaster for two groups, treat 1 course of treatment after, the statistical observation curative effect.
3, observation of curative effect
3.1 criterion of therapeutical effect is cured: the equal complete obiteration of pain and tenderness, ability to work recover normal fully.Effectively: pain and tenderness alleviate, and it is normal or approaching normal that ability to work is recovered.Invalid: pain and tenderness all do not have and alleviate.
3.2 therapeutic outcome
Table 1 treatment group curative effect example (%)
Table 2. matched group 46 routine patient's curative effect examples (%)
Interpretation of result: the treatment group has reached 89% to the average effectiveness level of the pain of lumbar vertebra neck breast, and matched group on average has only 52%.Treatment group effect obviously is better than matched group.
4, discuss
The back cervical vertebra ache that degeneration joint of vertebral column hypertrophy and chronic lumbar muscle strain cause is common clinically disease, and sickness rate is very high, is the common total symptoms of many patients with low-back pain.According to statistics, the adult once 100% suffered from lumbago and backache, because the quickening of rhythm of life, the dog-eat-dog of society, tissue is to for a long time, repeatedly, the liveliness proof compressing that continues, hit, the not reaction of positive iso-stress of friction posture, make and organize hypertrophy and hypertrophy, compensatory to do, the accumulation delay forms chronic lumbar muscle strain, acute injury is without correct treatment in time, also can delay into chronic injury, it is congested that tissue appears in diseased region, edema, hypertrophy changes, and pathologic such as granulation tissue formation and adhesion change, the primary disease pilosity is born in person between twenty and fifty, and overwork is once arranged, the medical history of damage and waist wound.This disease clinical treatment is difficulty comparatively, does not still have specific short, and we find in matched group, the analgesic agent gastrointestinal reaction is obvious, a lot of patients take medicine back sense gastral cavilty portion discomfort, pain, feel sick etc., and can not take medicine, and take for a long time to form and rely on and the reduction effect.Bighead atractylodes rhizome spine ache tablet is to study according to Chinese medicine theory and combining modern medicine, soak formulated with the natural Chinese medicinal herb Rhizoma Atractylodis Macrocephalae through milk, find that in clinical practice and in observing it is remarkable especially to degenerative osteoarthropathy and chronic lumbar muscle strain curative effect, is better than other therapies.Effect with replenishing QI to invigorate the spleen, damp-clearing pain-relieving.Through clinical application for many years, treatment degeneration spinal hyperosteogeny and chronic lumbar muscle strain are evident in efficacy.This side is simple and easy to preparation, and curative effect is reliable, and side effect is little, is better than Western medicine spasmolysis and analgesia class, is worthy of popularization.
Claims (3)
1, bighead atractylodes rhizome spine ache tablet is characterized in that making after soaking in milk with the Chinese medicine Rhizoma Atractylodis Macrocephalae.
2, bighead atractylodes rhizome spine ache tablet according to claim 1 is made tablet after it is characterized in that also adding starch, sucrose, magnesium stearate.
3, bighead atractylodes rhizome spine ache tablet according to claim 1 and 2 is characterized in that preparation technology is:
Get about 4000 grams of the Rhizoma Atractylodis Macrocephalae, soaked about 12 hours with fresh milk, 100 mesh sieves were pulverized in oven dry, and it is standby to get 3000 grams, gets the Rhizoma Atractylodis Macrocephalae and remaining Rhizoma Atractylodis Macrocephalae powder again, adds 8 times in water for the first time, extracts 60 minutes; For the second time add 6 times in water, extracted merge extractive liquid, 40 minutes, filter, filtrate concentrating adds equivalent 95% ethanol, stirs, left standstill 12-24 hour, the elimination supernatant reclaims ethanol, and it is standby to be concentrated into the 2000-2200 milligram, get sucrose again and pulverized 100 mesh sieves, add starch, Rhizoma Atractylodis Macrocephalae powder mixing crosses 80 mesh sieves and concentrated solution is mixed thoroughly, pelletizing press sheet 20000-21000 sheet, sheet weighs 0.3 gram, every contains Rhizoma Atractylodis Macrocephalae extractum 1.25 gram.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610043151 CN1899346A (en) | 2006-07-01 | 2006-07-01 | Bighead atractylodes rhizome spine ache tablet |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200610043151 CN1899346A (en) | 2006-07-01 | 2006-07-01 | Bighead atractylodes rhizome spine ache tablet |
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| CN1899346A true CN1899346A (en) | 2007-01-24 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103330795A (en) * | 2013-06-21 | 2013-10-02 | 张贞旺 | Preparation method of selenium-enriched codonopsis pilosula food soaking health care lotion |
| CN106890206A (en) * | 2017-04-19 | 2017-06-27 | 四川九渊医药科技有限公司 | Application of the bighead atractylodes rhizome essential oil in treatment degenerative osteoarthropathy medicine is prepared |
-
2006
- 2006-07-01 CN CN 200610043151 patent/CN1899346A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103330795A (en) * | 2013-06-21 | 2013-10-02 | 张贞旺 | Preparation method of selenium-enriched codonopsis pilosula food soaking health care lotion |
| CN106890206A (en) * | 2017-04-19 | 2017-06-27 | 四川九渊医药科技有限公司 | Application of the bighead atractylodes rhizome essential oil in treatment degenerative osteoarthropathy medicine is prepared |
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