CN106890206A - Application of the bighead atractylodes rhizome essential oil in treatment degenerative osteoarthropathy medicine is prepared - Google Patents
Application of the bighead atractylodes rhizome essential oil in treatment degenerative osteoarthropathy medicine is prepared Download PDFInfo
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Abstract
The invention provides bighead atractylodes rhizome essential oil pharmaceutical field new application.Specially application of the bighead atractylodes rhizome essential oil in treatment degenerative osteoarthropathy medicine is prepared.Bighead atractylodes rhizome essential oil can effectively improve the physicochemical property of joint fluid, improve the symptoms such as pain, the swelling of patient.Bighead atractylodes rhizome essential oil can effectively treat degenerative osteoarthropathy, such as disc herniation, foraminal stenosis, meniscus injury, osteoproliferation.Bighead atractylodes rhizome essential oil is prepared and easy to use, is easy to patient to use, and toxic and side effect is low.
Description
Technical field
The present invention relates to pharmaceutical field, more particularly to bighead atractylodes rhizome essential oil answering in treatment degenerative osteoarthropathy medicine is prepared
With.
Background technology
Degenerative osteoarthropathy is also known as osteoarthritis, DA, senescent arthritis, hypertrophiarthritis
A kind of retrogression pathological changes, are to draw due to increasing the factors such as age, obesity, strain, wound, joint birth defect, joint deformity
Articular cartilage degeneration damage, joint margins and the subchondral bone reactive hyperplasia for rising.This disease is more common in mid-aged population, is apt to occur in
Weight-bearing joints and the more joint of activity (e.g., cervical vertebra, lumbar vertebrae, knee joint, hip joint etc.).Excessively bear a heavy burden or closed using these
Section, the generation that can promote degeneration to change.Clinical manifestation be the arthralgia of slow development, tenderness, stiff, arthroncus,
Limitation of activity and joint deformity etc..
Degenerative osteoarthropathy is treated currently without particularly effective medicine, mainly by physiotherapy, slows down the course of disease
Development；Medication is mainly easing pain and diminishing inflammation, temporarily mitigates the pain of patient；When the state of an illness is very serious, can perform the operation, but to people
Bulk damage is very big, is also easy to recurrence.
The content of the invention
Treatment degeneration Bones and joints are being prepared it is an object of the invention to provide the new application of bighead atractylodes rhizome essential oil, i.e. bighead atractylodes rhizome essential oil
Application in medicine.
Degenerative osteoarthropathy of the present invention includes disc herniation, foraminal stenosis, meniscus injury, hyperostosis
It is raw.
Wherein, bighead atractylodes rhizome essential oil includes 80-90 parts of atractylone, 25-40 atractylols and 15-25 parts of atractylodes lactone.Preferably, in vain
Art essential oil includes 85-90 parts of atractylone, 30-40 parts of atractylol and 20-25 parts of atractylodes lactone.
The method for preparing bighead atractylodes rhizome essential oil be after the bighead atractylodes rhizome is crushed according to mass ratio be 1：The ratio and deionized water of 0.3-1.2
Mixing, and soak 7-24 hours.The bighead atractylodes rhizome for moistening is heated using water vapour, obtains mixed vapour.Condensation mixed vapour
Oil water mixture is obtained, carrying out water-oil separating to oil water mixture obtains bighead atractylodes rhizome essential oil.Particle diameter after wherein the bighead atractylodes rhizome is crushed is 4-
7mm。
Prepare bighead atractylodes rhizome essential oil method can also be the bighead atractylodes rhizome is crushed after according to mass ratio be 1：The ratio of 2-15 is mixed with water
Merging is boiled distillation and obtains mixed vapour.Water-oil separating is carried out after condensation mixed vapour obtain bighead atractylodes rhizome essential oil.
By clinical trial bighead atractylodes rhizome essential oil in treatment degenerative osteoarthropathy, such as disc herniation, foraminal stenosis, first quarter moon
Dash-board injury, osteoproliferation have good curative effect.Find that what bighead atractylodes rhizome essential oil can be effective changes by the detection clinically to joint fluid
The physicochemical property of kind joint fluid so that the physicochemical property of joint fluid is normal, and then shows that it has obvious curative effect.
It can thus be appreciated that beneficial effects of the present invention are：
Application of the present invention to bighead atractylodes rhizome essential oil is excavated, and has opened up bighead atractylodes rhizome essential oil in treatment degenerative osteoarthropathy medicine
In new application, wherein there is good curative effect for disc herniation, foraminal stenosis, meniscus injury, osteoproliferation.
Specific embodiment
To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below will be in the embodiment of the present invention
Technical scheme be clearly and completely described.Unreceipted actual conditions person, builds according to normal condition or manufacturer in embodiment
The condition of view is carried out.Agents useful for same or the unreceipted production firm person of instrument, are the conventional product that can be obtained by commercially available purchase
Product.
Bighead atractylodes rhizome essential oil is the total volatile oil extracted from Rhizoma Atractylodis Macrocephalae, and it can be applied to treat degenerative osteoarthropathy medicine
In, further can be applied to treatment disc herniation, foraminal stenosis, meniscus injury and osteoproliferation.The further bighead atractylodes rhizome
Essential oil includes 80-90 parts of atractylone, 25-40 atractylols and 15-25 parts of atractylodes lactone.It is further preferred that bighead atractylodes rhizome essential oil includes
85-90 parts of atractylone, 30-40 parts of atractylol and 20-25 parts of atractylodes lactone.
The not only a certain single material of performance drug effect in bighead atractylodes rhizome essential oil, but atractylone, atractylol, atractylodes lactone
Deng the common performance drug effect of many kinds of substance interaction.And ensure bighead atractylodes rhizome essential oil and be contained within above-mentioned ratio atractylone, atractylol, white
Art lactone is in order to ensure to play synergy between three, while the synergy reaches preferably effect.Bighead atractylodes rhizome essential oil
Interior atractylone, atractylol, the ratio of atractylodes lactone are not belonging to above-mentioned scope, bighead atractylodes rhizome essential oil treatment degenerative osteoarthropathy
Effect drastically declines even disappearance.
Atractylone is yellow liquid, dissolves in the organic solvents such as methyl alcohol, ethanol, DMSO, and atractylone has antibacterial, disease-resistant
The effect of poison, anti-inflammatory, detumescence, calmness, suppression cellular damage etc..Atractylone less stable, in the sun easy autoxidation
It is atractylodes lactone I and atractylodes lactone III, therefore, atractylone uses lucifuge sealing preserve.General is in dress using brown bottle.Rhizoma atractylodis
There is alcohol anti-inflammatory, liver protection, hypoglycemic, anti-oxidant etc. to act on.Atractylodes lactone has anti-inflammatory, enhancing immunity of organisms, promotes nutrition
The effects such as absorption of material.
Preparing the method for the bighead atractylodes rhizome essential oil for the treatment of degenerative osteoarthropathy is：
S1, the bighead atractylodes rhizome that will be commercially available carry out mechanical crushing, the size controlling of the bighead atractylodes rhizome after crushing in 4-7mm, preferably
The particle diameter of the bighead atractylodes rhizome is 6mm.
The bighead atractylodes rhizome crush and is easy to the follow-up material for needing to extract easily to dissolve or be evaporated, while increasing white
Art and the contact area of solvent, reduce the usage amount of solvent, meanwhile, the extraction time of active ingredient is shortened, and then save
Production cost.
S2, the bighead atractylodes rhizome that will be crushed are 1 according to mass ratio：The ratio of 0.3-1.2 mixes with deionized water and soaks bighead atractylodes rhizome 7-
24 hours.
Using the deionized water of this ratio, bighead atractylodes rhizome complete wetting can be caused, but the active material in the bighead atractylodes rhizome will not be caused
It is dissolved, is easy to follow-up operation.Meanwhile, if wetting is insufficient, when subsequently directly being extracted using vapor, it is impossible to completely
Active material in the bighead atractylodes rhizome is extracted, extraction efficiency is reduced.
S3, the bighead atractylodes rhizome for moistening is heated using vapor, obtain mixed vapour, condensation mixed vapour obtains profit and mixes
Compound, carries out water-oil separating and obtains bighead atractylodes rhizome essential oil to oil water mixture.
Vapor has energy higher, and the water to the bighead atractylodes rhizome surface when bighead atractylodes rhizome that it passes through moistening carries out hot friendship
Change so that water has energy higher, is then dissolved out the active material in the bighead atractylodes rhizome, vapor continues to carry out hot friendship with water
Change so that the energy of water is further lifted, and then it is steam to gasify, meanwhile, the active material being dissolved in water also is gasified
It is gas, as vapor together leaves the bighead atractylodes rhizome, and then reaches the effect of extraction.And when using vapor, vapor energy is high,
So that active material dissolution efficiency is high.Vapor is condensed into aqueous water after carrying out heat exchange with water, is attached to bighead atractylodes rhizome surface, enters one
Active material in the step ground dissolving bighead atractylodes rhizome, the vapor being then passed through carries out heat exchange, water is changed into vapor, takes away again with water
The bighead atractylodes rhizome.Whole process keeps the circulation of dissolving-evaporation-condensation-dissolving, it is ensured that the effect of extraction, improves extraction efficiency, together
When reduce the waste of raw material, saved production cost.The temperature of the vapor for using is 150-200 DEG C.
The mixed vapour for obtaining is condensed at room temperature.The activity major part obtained from the bighead atractylodes rhizome is ethereal oil, its
It is water insoluble, there is the line of demarcation of distinctness between water.Using simple Liquid liquid Separation equipment, such as separatory funnel.
The method for preparing the bighead atractylodes rhizome essential oil for the treatment of degenerative osteoarthropathy can also be：
After the bighead atractylodes rhizome is crushed according to mass ratio be 1：The ratio of 2-15 mixes with water and boils distillation and obtains mixed vapour.It is cold
Water-oil separating is carried out after solidifying mixed vapour obtain bighead atractylodes rhizome essential oil.
The particle size range of the bighead atractylodes rhizome after crushing is 4-7mm, it is therefore preferable to 6mm.Due to the method, to use the bighead atractylodes rhizome direct
Boiled with water Hybrid Heating and extracted, in order to ensure extraction effect, it is necessary to increase using water.Meanwhile, after boiling, in the bighead atractylodes rhizome
Active material dissolution rate and quantity increase, improve extraction efficiency.Boil so that water is changed into vapor, drive volatilization
Property material outflow, and then complete extract.Then vapor and volatile oil are carried out condensing the water for obtaining liquid and fluid,
Water oil is immiscible, carries out Liquid liquid Separation and obtains bighead atractylodes rhizome essential oil, for example, directly separated using separatory funnel.
Activity substance content is higher in the bighead atractylodes rhizome essential oil for preparing, when directly being acted on human body, site of action meeting
There are the phenomenons such as violent pain, redness, it is impossible to play therapeutic effect, may further aggravate the pain of patient, increase
The incidence of disease of patient.In order to ensure therapeutic effect, slow down the side effect after patient's use, typically by bighead atractylodes rhizome essential oil and fat oil,
The greases such as maize germ oil, rapeseed oil, soybean oil be mixed with obtaining finish.The ratio of the grease for using is bighead atractylodes rhizome essential oil
The 3-10% of usage amount.
Embodiment 1
Bighead atractylodes rhizome essential oil includes 8.5g atractylones, 3g atractylols and 1.5g atractylodes lactones.Bighead atractylodes rhizome essential oil passes through following steps system
：The 1Kg bighead atractylodes rhizomes are crushed, particle diameter is 5 millimeters, is then mixed with 1Kg deionized waters, the moistening 1Kg bighead atractylodes rhizomes 13 hours.Constantly will
150 DEG C of vapor slow transits through the bighead atractylodes rhizome of moistening, then condenses the mixed vapour by moistening the bighead atractylodes rhizome, obtains oil mixing with water
Thing, carries out water-oil separating and obtains bighead atractylodes rhizome essential oil using separatory funnel.
Embodiment 2
Bighead atractylodes rhizome essential oil includes 8g atractylones, 2.5g atractylols and 1.5g atractylodes lactones.Bighead atractylodes rhizome essential oil passes through following steps system
：The 0.9Kg bighead atractylodes rhizomes are crushed, particle diameter is 6 millimeters, is then mixed with 0.45Kg deionized waters, the moistening 0.9Kg bighead atractylodes rhizomes 7 hours.No
The disconnected bighead atractylodes rhizome that 170 DEG C of vapor is slow transitted through moistening, then condenses the mixed vapour by moistening the bighead atractylodes rhizome, obtains profit and mixes
Compound, carries out water-oil separating and obtains bighead atractylodes rhizome essential oil using separatory funnel.
Embodiment 3
Bighead atractylodes rhizome essential oil includes 9g atractylones, 3.5g atractylols and 2.5g atractylodes lactones.Bighead atractylodes rhizome essential oil passes through following steps system
：The 1.1Kg bighead atractylodes rhizomes are crushed, particle diameter is 7 millimeters, is then mixed with 0.33Kg deionized waters, the moistening 1.1Kg bighead atractylodes rhizomes 20 hours.
200 DEG C of vapor is constantly slow transitted through the bighead atractylodes rhizome of moistening, the mixed vapour by moistening the bighead atractylodes rhizome is then condensed, profit is obtained
Mixture, carries out water-oil separating and obtains bighead atractylodes rhizome essential oil using separatory funnel.
Embodiment 4
Bighead atractylodes rhizome essential oil includes 8.2g atractylones, 4g atractylols and 2g atractylodes lactones.Bighead atractylodes rhizome essential oil is obtained by following steps：
The 1.2Kg bighead atractylodes rhizomes are crushed, particle diameter is 4 millimeters, is then mixed with 1.44Kg deionized waters, the moistening 1.2Kg bighead atractylodes rhizomes 24 hours.Constantly
170 DEG C of vapor is slow transitted through the bighead atractylodes rhizome of moistening, the mixed vapour by moistening the bighead atractylodes rhizome is then condensed, oil mixing with water is obtained
Thing, carries out water-oil separating and obtains bighead atractylodes rhizome essential oil using separatory funnel.
Embodiment 5
Bighead atractylodes rhizome essential oil includes 8.2g atractylones, 2.7g atractylols and 1.8g atractylodes lactones.Bighead atractylodes rhizome essential oil passes through following steps
It is obtained：The 0.94Kg bighead atractylodes rhizomes are crushed, particle diameter is 5 millimeters, is then mixed with 0.75Kg deionized waters, the moistening 0.94Kg bighead atractylodes rhizomes 16 are small
When.180 DEG C of vapor is constantly slow transitted through the bighead atractylodes rhizome of moistening, the mixed vapour by moistening the bighead atractylodes rhizome is then condensed, obtained
Oil water mixture, carries out water-oil separating and obtains bighead atractylodes rhizome essential oil using separatory funnel.
Embodiment 6
Bighead atractylodes rhizome essential oil includes 8.7g atractylones, 3.2g atractylols and 1.7g atractylodes lactones.Bighead atractylodes rhizome essential oil passes through following steps
It is obtained：The 0.98Kg bighead atractylodes rhizomes are crushed, particle diameter is 6 millimeters, is then mixed with 0.79Kg deionized waters, the moistening 0.98Kg bighead atractylodes rhizomes 10 are small
When.160 DEG C of vapor is constantly slow transitted through the bighead atractylodes rhizome of moistening, the mixed vapour by moistening the bighead atractylodes rhizome is then condensed, obtained
Oil water mixture, carries out water-oil separating and obtains bighead atractylodes rhizome essential oil using separatory funnel.
Embodiment 7
Bighead atractylodes rhizome essential oil includes 8.4g atractylones, 3.7g atractylols and 2.3g atractylodes lactones.Bighead atractylodes rhizome essential oil passes through following steps
It is obtained：The 1.1Kg bighead atractylodes rhizomes are crushed, particle diameter is 5 millimeters, then mix and boil distillation with 2.2Kg deionized waters and obtain mixing steaming
Vapour, then condenses mixed vapour, obtains oil water mixture, and carrying out water-oil separating using separatory funnel obtains bighead atractylodes rhizome essential oil.
Embodiment 8
Bighead atractylodes rhizome essential oil includes 8.8g atractylones, 3.8g atractylols and 2.2g atractylodes lactones.Bighead atractylodes rhizome essential oil passes through following steps
It is obtained：The 1.3Kg bighead atractylodes rhizomes are crushed, particle diameter is 7 millimeters, then mix and boil distillation with 19.5Kg deionized waters and obtain mixing steaming
Vapour, then condenses mixed vapour, obtains oil water mixture, and carrying out water-oil separating using separatory funnel obtains bighead atractylodes rhizome essential oil.
Embodiment 9
Bighead atractylodes rhizome essential oil includes 8.6g atractylones, 2.9g atractylols and 1.9g atractylodes lactones.Bighead atractylodes rhizome essential oil passes through following steps
It is obtained：The 1.12Kg bighead atractylodes rhizomes are crushed, particle diameter is 6 millimeters, then mixes with 8.96Kg deionized waters and boils distillation and is mixed
Steam, then condenses mixed vapour, obtains oil water mixture, and carrying out water-oil separating using separatory funnel obtains bighead atractylodes rhizome essential oil.
Embodiment 10
Bighead atractylodes rhizome essential oil includes 8.1g atractylones, 2.6g atractylols and 1.7g atractylodes lactones.Bighead atractylodes rhizome essential oil passes through following steps
It is obtained：The 1.18Kg bighead atractylodes rhizomes are crushed, particle diameter is 6 millimeters, then mixes with 11.8Kg deionized waters and boils distillation and is mixed
Steam, then condenses mixed vapour, obtains oil water mixture, and carrying out water-oil separating using separatory funnel obtains bighead atractylodes rhizome essential oil.
Embodiment 11
Bighead atractylodes rhizome essential oil includes 8.3g atractylones, 3.1g atractylols and 2.4g atractylodes lactones.Bighead atractylodes rhizome essential oil passes through following steps
It is obtained：The 1.25Kg bighead atractylodes rhizomes are crushed, particle diameter is 6 millimeters, then mix and boil distillation with 7.5Kg deionized waters and obtain mixing steaming
Vapour, then condenses mixed vapour, obtains oil water mixture, and carrying out water-oil separating using separatory funnel obtains bighead atractylodes rhizome essential oil.
Experimental example
The present invention using with bighead atractylodes rhizome essential oil as treatment degenerative osteoarthropathy medicine in terms of pharmacological evaluation and result come
Illustrate its new application in pharmaceutical field.
Human trial 1
Test example is the bighead atractylodes rhizome essential oil of embodiment 1, and comparative example 1 is to contain 7g atractylones, 1g atractylols and 1g atractylodes lactones
Bighead atractylodes rhizome essential oil；Comparative example 2 is the bighead atractylodes rhizome essential oil containing 10g atractylones, 6 art alcohol and 5g atractylodes lactones.
Concrete operation method
156 patients are divided into 3 groups by the age in 30-50 one full year of life, 156 degenerated joint case patients, and one of which makes
With the bighead atractylodes rhizome essential oil of comparative example 1, one group of bighead atractylodes rhizome essential oil using comparative example 2, last is organized and uses the bighead atractylodes rhizome essential oil of embodiment 1.
It is daily 7 points, in 15 points and 23 points 3 periods smear the finish that 1 gram of corresponding bighead atractylodes rhizome essential oil is made in affected areas, and
Massage 15 minutes, is generated heat and is advisable slightly with affected areas.
Wherein, by pain, arthroncus, tenderness, stiff mitigation be set to effectively；By pain, tenderness, stiff, swollen joint
Swollen more than one disappearance, the mitigation of other limitation of activity and joint deformity limitation of activity is judged to effective；By arthralgia, pressure
Bitterly, stiff, arthroncus disappears, the mitigation of limitation of activity and joint deformity limitation of activity, or confirms hyperplasia or prominent through film making
Go out partial ablation or partial ablation, be judged to recovery from illness.
3 groups of example patients are paid a return visit and filled in return visit information at 30 days and 60 days respectively.Use the bighead atractylodes rhizome essence of comparative example 1
The return visit information of oil is shown in Table 1, and 2 are shown in Table using the return visit information of the bighead atractylodes rhizome essential oil of comparative example 2, uses the bighead atractylodes rhizome essential oil of embodiment 1
Return visit information be shown in Table 3.
The return visit information of the bighead atractylodes rhizome essential oil of the comparative example 1 of table 1
| It is invalid | Effectively | It is effective | Recovery from illness | |
| 30 days | 40 | 9 | 3 | 0 |
| 60 days | 36 | 11 | 5 | 0 |
The return visit information of the bighead atractylodes rhizome essential oil of the comparative example 2 of table 2
| It is invalid | Effectively | It is effective | Recovery from illness | |
| 30 days | 52 | 0 | 0 | 0 |
| 60 days | 49 | 3 | 0 | 0 |
The return visit information of the bighead atractylodes rhizome essential oil of the embodiment 1 of table 3
Clinical Practice is proved：Bighead atractylodes rhizome essential oil is contained within 80-90 parts of atractylone, 25-40 parts of atractylol and the 15-25 parts of bighead atractylodes rhizome
During lactone, degenerative joint disease can be effectively treated, if the ratio of active material is higher or lower than aforementioned proportion therapeutic effect
To drastically decline even without therapeutic effect.
By table 3, the bighead atractylodes rhizome essential oil of embodiment 1 can be used for the treatment of degenerative joint disease, effective using 30 days
69% is reached, and it is effective to have 29%, and 32% is reached using obvious effective rate after 60 days, cure rate reaches 68%.Bighead atractylodes rhizome essential oil
Action principle should be：Bighead atractylodes rhizome essential oil can be directly entered joint, tendon and the periosteum that lesion occurs by Transdermal absorption, change
The microcirculation at kind retrogression pathological changes position, prevents the generation of further retrogression pathological changes, and the retrogression pathological changes to having occurred and that
Repaired.
Human trial 2
Joint fluid to 52 degenerated joint patients of the effect of embodiment 1 in human trial 1 is extracted and detected,
Detection 3 times is extracted altogether.The project of detection is joint liquid measure, outward appearance, cell number and the albumen quality of joint fluid.3 times for extracting
Joint fluid is respectively the joint fluid before unused bighead atractylodes rhizome essential oil, using the joint fluid after bighead atractylodes rhizome essential oil 30 days, use bighead atractylodes rhizome essential oil
Joint fluid after 60 days.Each detection project the results are shown in Table 4- tables 7.
The change of the joint liquid measure of table 4
The normal value of joint liquid measure is 0.1-4ml, and passes through table 4, after bighead atractylodes rhizome essential oil, degenerated joint sufferer
The quantity of the joint fluid of person substantially tails off, and the ratio for returning to normal value (0.1-4ml) using 60 days posterior joint liquid measures is 65%, is closed
Section liquid measure reduces and reduces the extruding to joint and then reduce the pain of patient, while eliminating swelling.
The joint fluid outward appearance of table 5
The outward appearance of natural joint liquid does not solidify for colourless, transparent, standing.And passing through table 5,52 patients are not used in vain
The color of joint fluid is abnormal during art essential oil, and highest there is also mild inflammation.Use the color of bighead atractylodes rhizome essential oil posterior joint liquid
Change significantly, color gradually becomes shallower as, show that IA inflammation is gradually reduced, or even after using 60 days, the pass of patient
The outward appearance for saving liquid is substantially returned to normally, and only small number of patients is likely present slight inflammation.
Cell number in the joint fluid of table 6
Normal cell number is 200-750/mm in joint fluid3, by table 6, use patient after bighead atractylodes rhizome essential oil
Cell quantity in joint fluid is substantially reduced, and normal model is returned to using the cell quantity of the joint fluid of 81% patient after 60 days
In enclosing, show that bighead atractylodes rhizome essential oil can effectively suppress and reduce the propagation of cell, and then reduce the pressure in joint, alleviate joint
Load.
Albumen quality in the joint fluid of table 7
| 11-22g/L | 22-30g/L | 30-35g/L | >35g/L | |
| It is not used | 0 | 11 | 29 | 12 |
| Use 30 days | 17 | 23 | 7 | 5 |
| Use 60 days | 44 | 8 | 0 | 0 |
Protein in natural joint liquid is 11-22g/L, and passes through table 7, and the protein that 52 patients most start contains
Amount it is abnormal, using bighead atractylodes rhizome essential oil 30 days after, the protein content for having 32% or so patient articular's liquid returns to normal value,
Though the content of the joint fluid protein of remaining patient is not recovered in range of normal value, with substantially reduction, and use white
After art essential oil 60 days, the protein content of 85% patient returns to normal value, and the protein of only 15% or so patient contains
Amount remains above normal value, but substantially close to normal value, protein content has not existed far above the patient of normal value.
Human trial 3
By 30-50 one full year of life, 20 disc herniation patients, daily 7 points, in 15 points and 23 points 3 periods in illness
The finish that 1 gram of bighead atractylodes rhizome essential oil of embodiment 1 is made is smeared in region, and is massaged 15 minutes, is generated heat slightly with affected areas and is advisable.
Wherein, by pain, arthroncus, tenderness, stiff mitigation be set to effectively；By pain, tenderness, stiff, swollen joint
Swollen more than one disappearance, the mitigation of other limitation of activity and joint deformity limitation of activity is judged to effective；By arthralgia, pressure
Bitterly, stiff, arthroncus disappears, the mitigation of limitation of activity and joint deformity limitation of activity, or confirms hyperplasia or prominent through film making
Go out partial ablation or partial ablation, be judged to recovery from illness.
20 patients were paid a return visit and return visit information is filled at 30 days and 60 days respectively.Return visit the results are shown in Table 8.
The disc herniation patient's return visit information of table 8
| It is invalid | Effectively | It is effective | Recovery from illness | |
| 30 days | 0 | 12 | 8 | 0 |
| 60 days | 0 | 0 | 8 | 12 |
By table 8, after bighead atractylodes rhizome essential oil 30 days, 60% disc herniation patient feels effective, there is 40%
Patient thinks effective, and after using 60 days, 60% patient's recovery from illness.Result shows that bighead atractylodes rhizome essential oil can effectively cure intervertebral
Disk is protruded.
Human trial 4
By 30-50 one full year of life, 30 foraminal stenosis patients, daily 7 points, in 15 points and 23 points 3 periods in ill area
The finish that 1 gram of bighead atractylodes rhizome essential oil of embodiment 1 is made is smeared in domain, and is massaged 15 minutes, is generated heat slightly with affected areas and is advisable.
Wherein, by pain, arthroncus, tenderness, stiff mitigation be set to effectively；By pain, tenderness, stiff, swollen joint
Swollen more than one disappearance, the mitigation of other limitation of activity and joint deformity limitation of activity is judged to effective；By arthralgia, pressure
Bitterly, stiff, arthroncus disappears, the mitigation of limitation of activity and joint deformity limitation of activity, or confirms hyperplasia or prominent through film making
Go out partial ablation or partial ablation, be judged to recovery from illness.
30 patients were paid a return visit and return visit information is filled at 30 days and 60 days respectively.Return visit the results are shown in Table 9.
The foraminal stenosis patient's return visit information of table 9
| It is invalid | Effectively | It is effective | Recovery from illness | |
| 30 days | 0 | 20 | 10 | 0 |
| 60 days | 0 | 0 | 8 | 22 |
By table 9, after bighead atractylodes rhizome essential oil 30 days, 67% patient thinks effective, and 33% patient thinks effective,
And 73% foraminal stenosis patient fully recovers after using 60 days, 17% patient is effective, as a result shows that bighead atractylodes rhizome essential oil is narrow for vertebral foramen
It is narrow to have obvious therapeutic effect.
Human trial 5
By 30-50 one full year of life, 28 meniscus injury patients, daily 7 points, in 15 points and 23 points 3 periods in illness
The finish that 1 gram of bighead atractylodes rhizome essential oil of embodiment 1 is made is smeared in region, and is massaged 15 minutes, is generated heat slightly with affected areas and is advisable.
Wherein, by pain, arthroncus, tenderness, stiff mitigation be set to effectively；By pain, tenderness, stiff, swollen joint
Swollen more than one disappearance, the mitigation of other limitation of activity and joint deformity limitation of activity is judged to effective；By arthralgia, pressure
Bitterly, stiff, arthroncus disappears, the mitigation of limitation of activity and joint deformity limitation of activity, or confirms hyperplasia or prominent through film making
Go out partial ablation or partial ablation, be judged to recovery from illness.
28 patients were paid a return visit and return visit information is filled at 30 days and 60 days respectively.Return visit the results are shown in Table 10.
The meniscus injury patient's return visit information of table 10
| It is invalid | Effectively | It is effective | Recovery from illness | |
| 30 days | 0 | 20 | 8 | 0 |
| 60 days | 0 | 7 | 6 | 15 |
By table 10, after bighead atractylodes rhizome essential oil 30 days, 71% patient thinks effective, and 29% patient thinks aobvious
Effect, and 53% foraminal stenosis patient fully recovers after using 60 days, 22% patient is effective, and 25% patient thinks effective, as a result
Show that bighead atractylodes rhizome essential oil has certain therapeutic effect for meniscus injury.
Human trial 6
By 30-50 one full year of life, 30 osteoproliferation patients, daily 7 points, in 15 points and 23 points 3 periods in ill area
The finish that 1 gram of bighead atractylodes rhizome essential oil of embodiment 1 is made is smeared in domain, and is massaged 15 minutes, is generated heat slightly with affected areas and is advisable.
Wherein, by pain, arthroncus, tenderness, stiff mitigation be set to effectively；By pain, tenderness, stiff, swollen joint
Swollen more than one disappearance, the mitigation of other limitation of activity and joint deformity limitation of activity is judged to effective；By arthralgia, pressure
Bitterly, stiff, arthroncus disappears, the mitigation of limitation of activity and joint deformity limitation of activity, or confirms hyperplasia or prominent through film making
Go out partial ablation or partial ablation, be judged to recovery from illness.
30 patients were paid a return visit and return visit information is filled at 30 days and 60 days respectively.Return visit the results are shown in Table 11.
The osteoproliferation patient's return visit information of table 11
| It is invalid | Effectively | It is effective | Recovery from illness | |
| 30 days | 0 | 23 | 7 | 0 |
| 60 days | 0 | 0 | 6 | 24 |
By table 11, after bighead atractylodes rhizome essential oil 30 days, 77% patient thinks effective, and 23% patient thinks aobvious
Effect, and 80% osteoproliferation patient fully recovers after using 60 days, 20% patient thinks effective, as a result show bighead atractylodes rhizome essential oil for
Osteoproliferation has good therapeutic effect.
Human trial 7
Concrete operation method
Age in 30-50 one full year of life, 52 degenerated joint case patients, daily 7 points, in 15 points and 23 points 3 when
Section smears the finish that 1 gram of bighead atractylodes rhizome essential oil of embodiment 2 is made in affected areas, and massages 15 minutes, is generated heat slightly with affected areas
It is advisable.
Wherein, by pain, arthroncus, tenderness, stiff mitigation be set to effectively；By pain, tenderness, stiff, swollen joint
Swollen more than one disappearance, the mitigation of other limitation of activity and joint deformity limitation of activity is judged to effective；By arthralgia, pressure
Bitterly, stiff, arthroncus disappears, the mitigation of limitation of activity and joint deformity limitation of activity, or confirms hyperplasia or prominent through film making
Go out partial ablation or partial ablation, be judged to recovery from illness.
52 patients were paid a return visit and return visit information is filled at 30 days and 60 days respectively.Use the bighead atractylodes rhizome essential oil of embodiment 2
Return visit information is shown in Table 12.
The return visit information of the bighead atractylodes rhizome essential oil of the embodiment 2 of table 12
| It is invalid | Effectively | It is effective | Recovery from illness | |
| 30 days | 0 | 35 | 14 | 3 |
| 60 days | 0 | 0 | 15 | 37 |
By table 12, the bighead atractylodes rhizome essential oil of embodiment 2 is good for the therapeutic effect of degenerative joint disease, using white
After art essential oil 60 days, 72% patient's recovery from illness, 28% patient feels effective.
Human trial 8
Method and step of the experimental technique and step of this human trial with human trial 7 are consistent, and difference is
The bighead atractylodes rhizome essential oil for using is the bighead atractylodes rhizome essential oil of embodiment 5.Specific return visit information is shown in Table 13.
The return visit information of the bighead atractylodes rhizome essential oil of the embodiment 5 of table 13
| It is invalid | Effectively | It is effective | Recovery from illness | |
| 30 days | 0 | 34 | 14 | 4 |
| 60 days | 0 | 0 | 16 | 36 |
By table 13, the bighead atractylodes rhizome essential oil of embodiment 5 is good for the therapeutic effect of degenerative joint disease, using white
After art essential oil 60 days, 69% patient's recovery from illness, 31% patient feels effective.
Human trial 9
Method and step of the experimental technique and step of this human trial with human trial 7 are consistent, and difference is
The bighead atractylodes rhizome essential oil for using is the bighead atractylodes rhizome essential oil of embodiment 7.Specific return visit information is shown in Table 14.
The return visit information of the bighead atractylodes rhizome essential oil of the embodiment 7 of table 14
| It is invalid | Effectively | It is effective | Recovery from illness | |
| 30 days | 0 | 30 | 20 | 2 |
| 60 days | 0 | 2 | 14 | 36 |
By table 14, the bighead atractylodes rhizome essential oil of embodiment 7 is good for the therapeutic effect of degenerative joint disease, using white
After art essential oil 60 days, 69% patient's recovery from illness, 27% patient feels effective.
Human trial 10
Method and step of the experimental technique and step of this human trial with human trial 7 are consistent, and difference is
The bighead atractylodes rhizome essential oil for using is the bighead atractylodes rhizome essential oil of embodiment 10.Specific return visit information is shown in Table 15.
The return visit information of the bighead atractylodes rhizome essential oil of the embodiment 10 of table 15
| It is invalid | Effectively | It is effective | Recovery from illness | |
| 30 days | 0 | 28 | 19 | 5 |
| 60 days | 0 | 0 | 13 | 39 |
By table 15, the bighead atractylodes rhizome essential oil of embodiment 10 is good for the therapeutic effect of degenerative joint disease, is using
After bighead atractylodes rhizome essential oil 60 days, 75% patient's recovery from illness, 25% patient feels effective.
Human trial 11
Method and step of the experimental technique and step of this human trial with human trial 3 are consistent, and difference is
The bighead atractylodes rhizome essential oil for using is the bighead atractylodes rhizome essential oil of embodiment 3.Specific return visit information is shown in Table 16.
The return visit information of the bighead atractylodes rhizome essential oil of the embodiment 3 of table 16
| It is invalid | Effectively | It is effective | Recovery from illness | |
| 30 days | 0 | 13 | 7 | 0 |
| 60 days | 0 | 0 | 6 | 14 |
By table 16, the bighead atractylodes rhizome essential oil for implementing 3 is good for the therapeutic effect of disc herniation, is using bighead atractylodes rhizome essence
After 60 days, 70% patient's recovery from illness, 30% patient feels effective to oil.
Human trial 12
Method and step of the experimental technique and step of this human trial with human trial 3 are consistent, and difference is
The bighead atractylodes rhizome essential oil for using is the bighead atractylodes rhizome essential oil of embodiment 6.Specific return visit information is shown in Table 17.
The return visit information of the bighead atractylodes rhizome essential oil of the embodiment 6 of table 17
| It is invalid | Effectively | It is effective | Recovery from illness | |
| 30 days | 0 | 15 | 5 | 0 |
| 60 days | 0 | 0 | 4 | 16 |
By table 17, the bighead atractylodes rhizome essential oil for implementing 6 is good for the therapeutic effect of disc herniation, is using bighead atractylodes rhizome essence
After 60 days, 80% patient's recovery from illness, 20% patient feels effective to oil.
Human trial 13
Method and step of the experimental technique and step of this human trial with human trial 4 are consistent, and difference is
The bighead atractylodes rhizome essential oil for using is the bighead atractylodes rhizome essential oil of embodiment 2.Specific return visit information is shown in Table 18.
The return visit information of the bighead atractylodes rhizome essential oil of the embodiment 2 of table 18
| It is invalid | Effectively | It is effective | Recovery from illness | |
| 30 days | 0 | 22 | 8 | 0 |
| 60 days | 0 | 0 | 6 | 24 |
By table 18, the bighead atractylodes rhizome essential oil for implementing 2 is good for the therapeutic effect of foraminal stenosis, is using bighead atractylodes rhizome essential oil
After 60 days, 80% patient's recovery from illness, 20% patient feels effective.
Human trial 14
Method and step of the experimental technique and step of this human trial with human trial 4 are consistent, and difference is
The bighead atractylodes rhizome essential oil for using is the bighead atractylodes rhizome essential oil of embodiment 4.Specific return visit information is shown in Table 19.
The return visit information of the bighead atractylodes rhizome essential oil of the embodiment 4 of table 19
By table 19, the bighead atractylodes rhizome essential oil for implementing 4 is good for the therapeutic effect of foraminal stenosis, is using bighead atractylodes rhizome essential oil
After 60 days, 87% patient's recovery from illness, 13% patient feels effective.
Human trial 15
Method and step of the experimental technique and step of this human trial with human trial 5 are consistent, and difference is
The bighead atractylodes rhizome essential oil for using is the bighead atractylodes rhizome essential oil of embodiment 8.Specific return visit information is shown in Table 20.
The return visit information of the bighead atractylodes rhizome essential oil of the embodiment 8 of table 20
| It is invalid | Effectively | It is effective | Recovery from illness | |
| 30 days | 0 | 22 | 6 | 0 |
| 60 days | 0 | 5 | 6 | 17 |
By table 20, the bighead atractylodes rhizome essential oil for implementing 8 is good for the therapeutic effect of meniscus injury, is using bighead atractylodes rhizome essence
After 60 days, 61% patient's recovery from illness, 21% patient feels effective to oil.
Human trial 16
Method and step of the experimental technique and step of this human trial with human trial 5 are consistent, and difference is
The bighead atractylodes rhizome essential oil for using is the bighead atractylodes rhizome essential oil of embodiment 9.Specific return visit information is shown in Table 21.
The return visit information of the bighead atractylodes rhizome essential oil of the embodiment 9 of table 21
| It is invalid | Effectively | It is effective | Recovery from illness | |
| 30 days | 0 | 23 | 5 | 0 |
| 60 days | 0 | 6 | 8 | 14 |
By table 21, the bighead atractylodes rhizome essential oil for implementing 9 has certain curative effect for meniscus injury, is using bighead atractylodes rhizome essential oil
After 60 days, 50% patient's recovery from illness, 29% patient feels effective.
Human trial 17
Method and step of the experimental technique and step of this human trial with human trial 5 are consistent, and difference is
The bighead atractylodes rhizome essential oil for using is the bighead atractylodes rhizome essential oil of embodiment 11.Specific return visit information is shown in Table 22.
The return visit information of the bighead atractylodes rhizome essential oil of the embodiment 11 of table 22
| It is invalid | Effectively | It is effective | Recovery from illness | |
| 30 days | 0 | 24 | 3 | 1 |
| 60 days | 0 | 7 | 5 | 16 |
By table 22, the bighead atractylodes rhizome essential oil for implementing 11 is general for the therapeutic effect of meniscus injury, is using the bighead atractylodes rhizome
After essential oil 60 days, 57% patient's recovery from illness, 18% patient feels effective.
Human trial 18
Method and step of the experimental technique and step of this human trial with human trial 6 are consistent, and difference is
The bighead atractylodes rhizome essential oil for using is the bighead atractylodes rhizome essential oil of embodiment 11.Specific return visit information is shown in Table 23.
The return visit information of the bighead atractylodes rhizome essential oil of the embodiment 11 of table 23
| It is invalid | Effectively | It is effective | Recovery from illness | |
| 30 days | 0 | 24 | 6 | 1 |
| 60 days | 0 | 0 | 5 | 25 |
By table 23, the bighead atractylodes rhizome essential oil for implementing 11 is good for the therapeutic effect of osteoproliferation, is using bighead atractylodes rhizome essence
After 60 days, 83% patient's recovery from illness, 17% patient feels effective to oil.
Human trial 19
Method and step of the experimental technique and step of this human trial with human trial 6 are consistent, and difference is
The bighead atractylodes rhizome essential oil for using is the bighead atractylodes rhizome essential oil of embodiment 5.Specific return visit information is shown in Table 24.
The return visit information of the bighead atractylodes rhizome essential oil of the embodiment 5 of table 24
By table 24, the bighead atractylodes rhizome essential oil for implementing 5 is good for the therapeutic effect of osteoproliferation, is using bighead atractylodes rhizome essential oil
After 60 days, 87% patient's recovery from illness, 13% patient feels effective.
In sum, embodiment of the present invention bighead atractylodes rhizome essential oil can be effectively improved quantity, outward appearance, the reduction joint fluid of joint fluid
Interior cell quantity, reduces joint fluid internal protein content, and then mitigate swelling, the pain of patient illness part so that patient
Joint it is no longer stiff, can be bent, mitigate joint load.The bighead atractylodes rhizome essential oil of the embodiment of the present invention can be controlled effectively
Treat degenerative osteoarthropathy, such as disc herniation, foraminal stenosis, meniscus injury, osteoproliferation.Bighead atractylodes rhizome essential oil prepare and
It is easy to use, it is easy to patient to use, toxic and side effect is low.
Embodiments described above is a part of embodiment of the invention, rather than whole embodiments.Reality of the invention
The detailed description for applying example is not intended to limit the scope of claimed invention, but is merely representative of selected implementation of the invention
Example.Based on the embodiment in the present invention, what those of ordinary skill in the art were obtained under the premise of creative work is not made
Every other embodiment, belongs to the scope of protection of the invention.
Claims (10)
1. application of the bighead atractylodes rhizome essential oil in treatment degenerative osteoarthropathy medicine is prepared.
2. application according to claim 1, it is characterised in that the degenerative osteoarthropathy includes disc herniation.
3. application according to claim 1, it is characterised in that the degenerative osteoarthropathy includes foraminal stenosis.
4. application according to claim 1, it is characterised in that the degenerative osteoarthropathy includes meniscus injury.
5. application according to claim 1, it is characterised in that the degenerative osteoarthropathy includes osteoproliferation.
6. the application according to claim 1-5 any one, it is characterised in that by weight, the bighead atractylodes rhizome essential oil bag
Include 80-90 parts of atractylone, 25-40 parts of atractylol and 15-25 parts of atractylodes lactone.
7. application according to claim 6, it is characterised in that by weight, the bighead atractylodes rhizome essential oil includes 85-90 parts of institute
State atractylone, the 30-40 part of atractylol and the 20-25 parts of atractylodes lactone.
8. the application according to claim 1-5 any one, it is characterised in that the bighead atractylodes rhizome essential oil passes through following steps system
：
After the bighead atractylodes rhizome is crushed according to mass ratio be 1：The ratio of 0.3-1.2 mixes with deionized water, and soaks 7-24 hours；
The bighead atractylodes rhizome for moistening is heated using water vapour, obtains mixed vapour, condensed the mixed vapour and obtain profit
Mixture, water-oil separating is carried out to the oil water mixture and obtains the bighead atractylodes rhizome essential oil.
9. application according to claim 8, it is characterised in that the particle diameter after the bighead atractylodes rhizome is crushed is 4-7mm.
10. the application according to claim 1-5 any one, it is characterised in that the bighead atractylodes rhizome essential oil passes through following steps
It is obtained：
After the bighead atractylodes rhizome is crushed according to mass ratio be 1：The ratio of 2-15 mixes with water and boils distillation and obtains mixed vapour；
Oil water mixture is obtained after condensing the mixed vapour, the oil water mixture is carried out into water-oil separating obtains the bighead atractylodes rhizome
Essential oil.
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Application publication date: 20170627 |