CN1895066A - Anti-body leben tablet (powder) - Google Patents
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- CN1895066A CN1895066A CN 200610084964 CN200610084964A CN1895066A CN 1895066 A CN1895066 A CN 1895066A CN 200610084964 CN200610084964 CN 200610084964 CN 200610084964 A CN200610084964 A CN 200610084964A CN 1895066 A CN1895066 A CN 1895066A
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Abstract
An antibody-type sour milk tablet (or powder) for resisting against bacteria, virus and infection, improving immunity and preventing cold and influenza is prepared from sour yak milk powder, immune globulin, beta-glucosan, garlic oil, vitamins, trace elements and oligose through cleaning fresh milk, mixing with others, homogenizing, sterilizing, concentrating, fermenting, drying, die pressing, examining and packing.
Description
One, technical field: the invention belongs to common reinforcement sour milk tablet (powder) technical field.Relate in particular to the yak sour milk immunoglobulin (Ig), beta glucan, the functional food that raw materials such as garlic oil, vitamin C, vitamin E, β-carrot, vitamin B6, iron, zinc, selenium, stachyose process.
Two, background technology: the present invention is with the exclusive consumption ox fresh milk in Qinghai-Tibet Platean, through adding the sour milk that different lactobacillus-fermenteds forms is base-material, strengthened immunoglobulin (Ig), the functional yogurt sheet that raw materials such as beta glucan, garlic oil, vitamin C, vitamin E, beta carotene, vitamin B6, iron, zinc, selenium, stachyose process.This sour milk tablet has antiviral, and antibiotic anti-infective, raising immunologic function is prevented and treated influenza, functions such as flu.Existing market also not this functional yogurt sheet occur, develop this sour milk tablet and can be the dairy products industry a kind of novel functional yogurt sheet is provided.This sour milk tablet comprehensive nutrition has again and protects the energy of making contributions, and with the tablet capsules of market great majority employing at present, pharmaceutically dosage form health foods such as oral liquid are compared, and obviously have more affinity in mouthfeel and form.
Three, summary of the invention:
The present invention be directed to the popular of SARS in 2003, people have recognized the disease by virus infections, SARS, the plague, Aids fearful.Existing over one hundred time of human up to now influenza pandemic, global being very popular just has five times more than, billions of for this reason people's morbidities, tens of millions of people's death.Influenza has become the epidemic disease that human society must solve, and appropriate authority is strengthened the prevention work of influenza one after another both at home and abroad.The World Health Organization has sent influenza possibility pandemic " alarm " now, will cause grave danger for human health, is that people more and more pay close attention to the issuable damaging influence of global communicable disease.Promptly to research and development and the production defence common cold and the grippal food of this series products, health food has special social effect, is people's livelihood exigence, and a kind of functional health-care food of development.That this product has is antibiotic, antiviral, anti-inflammatory, prevent and treat multiple effects such as influenza, flu, raising immunologic function.
Its outward appearance is a milk yellow, does not have any peculiar smell, has the fragrance and the sour-sweet flavor of sour milk, and mouthfeel is gentle closes, smooth mouthful of garden.
Four, composition of raw materials: 92 kilograms of consumption ox fresh milks, 3 kilograms of leavenings, 1.2 kilograms in fructose, yeast 50 grams, 0.252 kilogram of immunoglobulin (Ig), 0.42 kilogram of beta glucan, 0.504 kilogram of garlic oil, 0.21 kilogram of vitamin C, vitamin E 6.3 grams, beta carotene 3.4 grams, Cobastab
61.26 1.26 kilograms of grams, ferrous lactate 35 gram, zinc gluconate 40.5 grams, Se-enriched yeast 0.25 gram, stachyose
Five, technical scheme:
The consumption ox: the consumption ox is the exclusive ox kind in blue or green finish plateau, accounts for 90% of world's consumption ox total amount, is grown in the Qinghai-Tibet Platean of height above sea level more than 3000 meters.Harsh especially natural environment has been brought up the consumption Newt and has been had anti-severe cold, high temperature resistant, intensive ultraviolet, the survival ability of anti-anoxic, anti-disease, and Here it is, and the unique distinction that ox can adapt to various extreme natural environments is consumed in the Qinghai-Tibet Platean.The nutritionist discovers, consumption Niu Quanshen is precious, because unique natural environment, the lactoferrin and the immunoglobulin content of consumption milk surpass common colostrum, other contained nutritional labeling is also considerably beyond ordinary milk, and this also is that the Nature awards the strong physique of the special favor of great Tibetan people and the ability of resist the disease.
(1) sour milk, sour milk is to be raw material with consumption ox new fresh milk, through having added the leavening of different strain, the sour milk product that fermentation forms, the nutrition of consumption milk is higher than ordinary milk, comprehensive nutrition balance, the functional food of easily digesting and assimilating, often drink have antibiotic, antiviral, strengthen immunologic function, anti-flu, regulate function of intestinal canal, promote to grow, improve intelligence, prevent and treat osteoporosis, suppress cholesterol, improve looks, delay senility, multiple function such as pre-anti-cancer.
Consumption ox sour milk contains 100 multiple nutritional components, protein 18 seed amino acids, and compositions such as fat, carbohydrate, vitamin, mineral matter, trace element, wherein the amino acid ratio of 8 kinds of needed by human is suitable, is particularly suitable for building up health and improving immunologic function.
Physiological function: 1, regulate immunologic function, sour milk has the body of raising disease resistance ability, regulates body, function of immune system.Contain abundant good protein in the yak sour milk, particularly immunoglobulin (Ig) and lactoferrin are particularly abundant, protein is the main component that constitutes white blood cell and antibody, experimental results show that, the people of famine can make the lymph corpuscle in the immunocyte subtract greatly, cause serious immunity function to descend the easy infection disease.Protein can also suppress virus in addition, and certain antitumaous effect interferon is arranged, and is the compound of sugar and protein.Sour milk not only shows the regulating action of immunologic function and improves on the intestine immunity function, also influential to systemic immune function, wherein sure to the effect that the activation and the peripheral blood antibody quantity of macrophage increases to take in sour milk, the cell factor aspect studies confirm that, long-term drinking contains the sour milk of live lactobacillus, and is particularly evident to the effect of malnutritive animal.
The researcher thinks, immunoregulatory activity material in the sour milk can be from 3 main aspects: lactic acid bacteria lives, the dead thalline of lactic acid bacteria, thalline composition and metabolite, the compositions such as active peptide that the lactic acid bacteria decomposing protein produces, wholesome composition increases such as vitamin and CLA may have certain effect in the sour milk in addition; And the balanced nutritious material in the sour milk also may improve immunity by improving physique.Simultaneously, the immunological regulation of sour milk comprises prevention and alleviates the alimentary infection that pathogen causes, alleviate the infantile diarrhea that rotavirus causes, alleviate autoimmunity diseases associated such as asthma, allergy and arthritis, improve the resistance of enteron aisle to various pathogens, improve radiation, stress, the immunologic function of aged animal.In addition, sour milk through the dehydration after, the casein of formation, the oligopeptide that contains at casein has the enhancing immunization.
3, anti-bacteria and anti-virus: sour milk contains multiple anti-bacteria and anti-virus material, comprises some protein components, as immunoglobulin (Ig), K-casein, lysozyme, ALA and lactoperoxidase etc.They can be complete or be present in the intestines and stomach of new born animal with big fragment, help brood opposing pathogenic bacteria and virus, lactoferrin can not only promote specific antibody to produce, the selectivity combination takes place in the DNA that regulates macrophage in the intestinal mucosa, cause the translation activation of some specific gene, as opposing defence line, microorganism second road.In addition, the IGF in the sour milk, EGF etc. also help the opposing infection and recover from enteric infection fast.
Protein in the sour milk can produce clearly immunomodulatory peptides of some structures through enzyme hydrolysis, but their activating immune systems strengthen the immune cell propagation reaction, or improve the resistance of animal body to pathogenic bacteria, they comprise casease, lactoferrin enzyme and alpha lactalbumin enzymic hydrolysates etc.
4, cancer-resisting: Spain and French scientific research institution discover that sour milk can stimulate interferon to produce, and interferon is a kind of protein of protecting cell, can treat cancer and other disease, and the diarrhoea that virus is caused has prevention effect.It is reported, the Norway researcher spent 6 years to follow up a case by regular visits to more than 4.8 ten thousand age the 34-39 year women of menopause not, getting rid of age, fecundity, hormonal readiness, body-mass index, schooling, find after the influence of factor such as physical training and alcohol, drink the women of three glasss of sour milks every day, and suffered from the breast cancer probability and reduce half.
(2) immunoglobulin (Ig) (lmmUnogikbulin, Ig).Immunoglobulin (Ig) (Ig) is that a class has antibody activity, the globulin that can combine with corresponding antigens generation specificity, and it does not exist only in the blood, also is present in body fluid, in mucous membrane juice and the bone-marrow-derived lymphocyte film.It is the main matter that constitutes the body fluid immunization, combine with antigen to cause some generation such as variation such as eliminating or poisoning and toxicity or process, but with killing bacteria and virus after complement combines, so can strengthen the body defence capability.
Immunoglobulin (Ig) is Y font structure, is made of 2 heavy chains and 2 light chains, and molecular weight is 150000～170000.The human immunoglobulin has five classes such as IgG, IgM, IgA, IgD, IgE, and that wherein play a major role in the body is IgG, and what play a major role in local immunity is secretory IgA.
Physiological function: 1, improve immunologic function; IgG has tangible raising immune function of human body, wherein IgG is than in the easier tissue space that is diffused in the blood of other Ig, in and bacteriotoxin, and combine with microorganism and strengthen phagocytic activity it, IgM belongs to a kind of cytotoxic antibody, there being complement system can destroy tumour cell under participating in, be a kind of dynamical antibody.That IgA has is antibiotic significantly, antitoxin and antivirus action.IgD, excites bone-marrow-derived lymphocyte and regulates in the immune response to play an important role at identification antigen as the important acceptor on bone-marrow-derived lymphocyte surface, therefore, Ig has powerful prevention effect to virus, bacterium and fungal infection, and the immunity-regulating function, strengthens the resistance to various diseases.
2, anti-bacteria and anti-virus: immunoglobulin (Ig) has antiviral significantly, antibiotic and disease-resistant plain effect, it is the bioactivator that foreign matters (antigen) such as virus and pathogenic bacteria have idiosyncrasy, wherein 1gM is the macroglobulin of molecular weight maximum, and spleen is the main composite part position of macroglobulin, IgM with can activating complement after antigen combines, have the function of very strong sterilization and neutralization virus.And the lymphokine that is produced by the T cell has nonspecific killing ability, plays a significant role in the nospecific immunity of antitumor and viral infection resisting.According to another report, immunoglobulin (Ig) can be used as urgent prevention and therapeutic agent, the virus that neutralizes and then the absorption of prevention virus and intrusion cell.Studies show that; mouse is carried out the anxious prevention of resisiting influenza virus to immunoglobulin (Ig) and treatment experimental results show that; inject 0.1 milliliter in the previous day of attacking poison to mouse peritoneal; immune protective rate can reach 100%; lumbar injection was 0.2 milliliter in 4 days in advance; immune protective rate reaches 100%, and injection was 0.2 milliliter in 8 days in advance, and immune protective rate reaches 80%.The result shows that control HPAIV, specific immune globulin are expected to become urgent prevention and treatment H5N1 infects effective preparation.
(3) garlic oil: garlic is the bulb of lily tannin plant garlic, warm in nature, flavor suffering.Have detumescence squama poison, functions such as desinsection, modern study think have antipathogen, sterilization, anti-inflammatory, antiviral.Strengthen immunity, effect such as anticancer.
Chemical composition: garlic mainly contains volatile oil, contains the sulfide compound that multiple pi-allyl, ethyl and methyl are formed in the volatile oil, compositions such as big allistatin, big plain new element, carbohydrate, several amino acids, protein and thick thousand dimension.
Pharmacological action:
1, strengthen immunologic function: garlic can obviously be improved the mouse macrophage phagocytic activity, quickens Congo red particle and removes from blood.Anthroposcopy shows that behind the injection garlic juice, lymphoblastic transformation rate and the reaction of rose soul bow structure are all significantly increased.According to another report, oral garlic homogenate can obviously strengthen immunity and the specific cellular immunity and the non-specific immune function of mouse cell.
2, antibiotic: galic essential oil has strong bactericidal action.Its 0.5% aqueous solution can be killed typhoid bacillus in 5 minutes.Garlic juice leachate and allicin are to staphylococcus, diplococcus meningitidis.Pneumococcus, corynebacterium diphtheriae, shigella dysenteriae, Escherichia coli, typhoid bacillus, paratyphosum Bacterium, tubercle bacillus etc. all have obvious suppression and killing action.The white skin garlic of purple garlic effect be strong, and garlic preparation is to penicillin, streptomysin, chloramphenicol, and the bacterium pearl of resistance is still responsive, and the inhibitory potency of natural allicin is to manually composite is similar.
3, antitumor: as to contain multiple cancer-resisting substance in the garlic oil, garlic oil can be blocked bacterium, the mould reduction to the nitrous amine salt, blocking-up bacterium, the mould facilitation synthetic to the nitrous amine salt, because the nitrosamine salt compound can bring out the multiple formation of organizing the organ pipe tumour, garlic oil can obviously reduce the nitrosamine salt content in the human body, show through studying for a long period of time, eat garlic more and can reduce by 60% incidence gastric cancer rate.Garlic oil has the anticancer interferon of generation in the body of stimulation simultaneously, increase anticancer and immunity, the activity that suppresses multiple harmful enzyme in the body, and enhance hepatocyte membrane stability, increase useful enzymatic activity, clinical trial shows that garlic oil can suppress and treat breast cancer, cutaneum carcinoma, knot are opened intestinal cancer, the carcinoma of the rectum, cancer of the esophagus, the generation of kinds of tumors such as liver cancer, lymph cancer.
4, antiviral: studies show that garlic P.E can be killed influenza virus B in external 0.15mg/ml concentration, 0.05mg/ml can kill herpes simplex virus.Garlic P.E has inhibitory action to macrophage virus, it is reported, Allicin can suppress the effect of HCMV cell death inducing.But one that is undertaken by the clinical virus research of attached Tongji University of hospital of Tongji University of Central China University of Science and Technology pediatric hospital at present studies show that, this effect of Allicin shows as double effect, Apoptosis for the macrophage virus induction, Allicin has the obvious suppression effect, and its mechanism may be with relevant with the fas expression by disturbing HCMV to influence apoptosis controlling gene bc1-2.
5, diuresis: experiment shows, to awarding garlic capsule in the anesthetized dog stomach, can produce the significantly diuresis relevant with dosage, natriuresis.
Garlic also has reducing blood lipid in addition, and hypotensive, hypoglycemic, inhibition platelet aggregation promotes organism metabolism, protect the liver, and antithrombotic, anti arteriosclerosis, anti-oxidant, the anti-ageing effect of waiting for a long time.
(4) (β-giucan), glucan is a kind of water-soluble dietary fiber that extracts from yeast to beta glucan, also has the Bifidobacterium active function.Glucan mainly is contained in the yeast wall.
Beta glucan is a main chain with β-1.3-glucan mainly, and β-1.6-glucan is a side chain, and molecular weight is 240,000.
Physiological function: 1, strengthen immunologic function; It is a kind of indigestible food fiber that the glucan human body is taken in back indigestion absorption, and the Bifidobacterium proliferation function is arranged.But the human immune system there is extremely strong influence, it has the function of activating cell, can prevent that also body is infected and repair the tissue that destroys, people are reduced by the immunity that the reason or the stress of physics causes, under radiation environment or irrational meals, all can make immunity impaired, beta glucan can impel the raising resistance, reduce the danger of communicate illness, tangible antitumor activity is arranged.
2, prevent and treat coronary heart disease: glucan can promote the drainage of intestinal toxic thing, effectively suppresses the last assorted of cholesterol in the blood, reduces cholesterol in the blood, thus the prevention coronary heart disease.
In addition, glucan can promote that also stomach need move, and improves the constipation situation.
(5), vitamin C (Vit C) has another name called ascorbic acid.Vitamin C is a kind of multi-functional vitamin, is the natural materials that extensively is present in fruit and the thin dish.Vitamin C is a white crystalline powder, has tangible tart flavour, and is soluble in water, should not process under high temperature and alkali condition.Vitamin C is a kind of simple six carbon compounds, and occurring in nature has two kinds of forms, i.e. reduced form ascorbic acid and oxidized form hydroascorbic acid, and the both has physiologically active, all can be utilized by body.
Physiological function: 1, participate in biosynthesis, vitamin C in vivo in the digestion process cofactors as substrate and enzyme participate in multiple important biosynthetic process, comprise collagen, carnitine, the metabolism of the synthetic and tyrosine of other neurotransmitter and peptide hormone etc., some enzyme require vitamin C could keep the activity of height.
2, improve immunologic function: vitamin C can promote prostaglandin and lymphocytic emiocytosis, makes body produce interferon and antitoxin, helps to regulate lymphocytic PGB 4.Interferon is to be used for break virus to combine with viral to reduce white blood cell, keeps leukocytic quantity, and leukocytic vitamin C can consume rapidly when generally catching a cold, therefore must the large dose oral administration vitamin C when flu, and with enhancing immunity.
3, anti-flu: vitamin C is to constitute collagen, safeguards skin, the integrality of respiratory mucosa and robustness; Sufficient vitamin C can help interior leucocyte of body and antibody to kill the invasion pathogenic microorganism, anti-flu.Vitamin C can stimulate health to make interferon (a kind of anti-cancer active matter), be used for break virus to reduce white blood cell and viral combining, keep the white blood cell number, vitamin C when common people catch a cold in the white blood cell can consume rapidly, therefore necessary a large amount of replenishing vitamins C during catching a cold are to strengthen immunity.
U.S. expert discovers that every day 1, gram left and right sides vitamin C can make flu descend 45%, and the course of disease shortens 60%, and vitamin C can be linked up respiratory apparatus and be stimulated circulation, and preventing respiratory infects, and increases the oxygen that body needs, and reduces flu and takes place.
In addition, vitamin C also has the cerebral function of improvement, antifatigue except above-mentioned functions, reduces cholesterol, safeguards health of heart, and protection cardiovascular and cerebrovascular, The Maintenance Of Skin Health are anti-oxidant, the anti-ageing function of waiting for a long time.
(6) Cobastab
6(Vit B
6), having another name called pyridoxol, pyridoxal and the pyrrole three kinds of native forms of ammonia of trembling all have the vitamin Cobastab
6Biologically active exists.Cobastab
6Soluble in water, to heat, acid, oxygen is comparatively stable, not alkaline-resisting, in neutral and alkaline environment, easily destroyed by ultraviolet ray.
Physiological function: 1, participate in metabolism: Cobastab
6Participate in a series of biochemical reaction, very close, especially very important with three major nutrient metabolism relation to protein metabolism.
2, amino acid metabolism: (1) transamination: amino acid such as alanine asparagine, arginine, cysteine, isoleucine, the transamination of lysine etc. needs Cobastab
6Participate in (2) decarboxylating; Tryptophan particularly is as the B that is deficient in vitamin
6The time can make xanthurenic acid (4,8-in the urine, 3-hydroxyl kynurenine and quinolinic acid are discharged and are increased, dehydroxylations such as tyrosine, histidine, DOPA, glutamic acid is converted into the r-aminobutyric acid in the middle cabinet nervous system, half Guang acid is converted into Taurine, also all needs Cobastab
6Participate in.
3, improve immunity: Cobastab
6Important function be the important substance that protein plays a role at human body, Cobastab
6Be protein metabolism, the necessary material of immune system running, in immune system, antibody has produced the coenzyme effect.B is deficient in vitamin
6Can cause that immune system degenerates, hemoglobin reduces, the histocyte anoxic, and body is to series reaction such as oxygen sensitivities, and brings out asthma.
In addition, Cobastab
6Also tool stimulates hemoglobin to produce, keep potassium, sodium,, the balance of chlorine, growth of human body all cells and regeneration, essential by keeping normal brain function nervous system activity, alleviation part fatigue and pressure, Cobastab
6Also have the cholesterol of reduction, AFL, prevent coronary heart disease, functions such as hypertension and cancer.
(7) vitamin E (Vit E) has another name called Vitamin E (CTOCOPhEROL).Be that α, β, y, δ and Vitamin E and α, β, y, δ-triolefin Vitamin E are called vitamin E with family system for 8 kinds.Wherein the biologically active of α-Vitamin E is the strongest.Vitamin E belong to liposoluble vitamin, water insoluble, to the oxygen sensitivity, is easy to oxidation and destroys, but accelerated oxidation under illumination, heat, alkali condition especially is more stable under acid and oxygen free condition.Vitamin E is the multifunctional and nutritional element.
Physiological function: 1, anti-oxidant: vitamin E is a kind of very strong antioxidant; avoid the infringement of free radical at the protection cell membrane; it is discord aliphatic acid that brain tissue cell contains a large amount of; vitamin E can prevent the oxidation of unrighted acid; thereby the eubolism of protection brain cell is with movable; prevent that brain is oxidized and fail that vitamin E also can prevent the oxidation of vitamin A, vitamin C and ATP, keeps their active functions in vivo.
2, remove free radical: vitamin E neuroprotective system, skeletal muscle, retina is avoided oxidative damage, and the normal development of nerve system of human body and retinal function need sufficient vitamin E.With a large amount of free-radical generating, so vitamin E is preventing mitochondria and is neurally touching the prominent infringement of avoiding free radical nervous system in producing the neurotransmitter process.
3, strengthen immunity: vitamin E is to keeping normal immunity function, and particularly very important to the lymphocytic function of T, immunocyte is very responsive to the infringement of radical reaction, and body vitamin E changed condition can make the reactivity of immunocyte change.Considerable evidence shows that old and feeble with immunity degradation, the elderly Yi Fa infects and tumour.Replenishing vitamins E can make delayed allergy Skin-test rate improve, the lymphocyte transformation test increased activity, vitamin E can also increase antibody, to remove filterable virus, bacterium and cancer cell, and vitamin E also can keep leukocytic constantly, prevents that the leukocyte cell film from producing anti-oxidant reaction.Studies confirm that no matter the elderly is young people also, sufficient vitamin E can significantly strengthen the anti-infection ability of T cell in the body, essential during therefore will eating the high food of content of vitamin E at ordinary times more and especially catching a cold.
One in the U.S. studies show that the E that supports one's family may have the effect of prevention respiratory tract infection to the elderly.
5, anti-ageing: vitamin E can be blocked and old and feeble relevant oxidation chain reaction, geriatric animals can be removed cell lipofuscin such as brain tissue after awarding vitamin E, and can improve skin elasticity, the sexual gland atrophy, hypomnesia etc., can also improve simultaneously the activity of enzyme, strengthen immunologic function, thus the delaying senility process.
In addition, vitamin E is eliminated fatigue and pressure in addition, prevents cardiovascular and cerebrovascular diseases, functions such as diabetic complication and tumour.
(8) (β-carotenes), carrotene is that the isoprene residue is that the conjugated double bond that the unit is formed is basic a kind of pigment to beta carotene, belongs to polyene pigment.Carrotene be distributed widely in the biology belong to fat-soluble, water insoluble.
Carrotene is present in the leaf texture of plant, also is present in flower, fruit, piece root and the stem tuber, and some microorganisms also can be synthesized carrotene, can not synthesize carrotene in the human body, and carrotene derives from plant kingdom.Beta carotene can be converted into vitamin A in human body, be vitamin a source.
Physiological function: 1, regulate immunologic function: it is reported that natural Beta-carotene can strengthen the non-specific and specific immune function of living organism.
(1) non-specific immune function: neutrophil cell is a kind of important leucocyte in the blood, it is the first line of defence of cell defence system, in immunologic process, neutrophil cell with free radical and active oxygen species as the weapon that kills and wounds the invasion pathogen, but in some cases, the generation of free radical may be excessive, thereby cause cells injury, the neutrophil cell afunction can cause the chronic infection of many non-pathogenic microorganisms, unsteered diabetic, the people of the cancer patient of chemotherapy and trouble immunologic deficiency disease often has the chronic infection of Candida.Studies show that; when under the condition that the human body neutrophil cell is being contained natural Beta-carotene and Candida during incubation; Candida is effectively killed; and neutrophil cell is not by radical damage and destruction; if lack natural Beta-carotene under incubation conditions, then neutrophil cell is damaged by the product that autoxidation produces, simultaneously; host cell around natural Beta-carotene also can be protected is avoided neutrophil cell unintentionally, does not add the damage of differentiation.
(2) specific immune function: except that neutrophil cell, immune system is resisted the ability that the spy grows pathogen infection in addition, i.e. cell-mediated immune responses, and the main cell that participates in cell-mediated immune response comprises T and bone-marrow-derived lymphocyte and macrophage.T and bone-marrow-derived lymphocyte have memory capability to special pathogen and inoculum, and when pathogen was invaded, immune response was just set up.Cell-mediated specific immune response can prevent virus, bacterium, fungi and parasitic infection.In addition, immune some cell also has identification, kills the ability of (repulsion) outer derived bacterium and tumour cell, circulate in vivo and have the function of kill tumor cell and infectious cell as NK, macrophage, T lymphocyte and NK are antineoplastic important cells.Lack beta carotene and can seriously weaken the resistance of body germ.
(3) macrophage: the macrophage membrane receptor participates in the identification of antigen, and provide antigen to T and bone-marrow-derived lymphocyte, secretion number of chemical medium and interferon, TNF, prostaglandin etc., make macrophage provide the ability of tumour antigen to strengthen, and tumour cell can produce immune repressor, suppresses the function of macrophage.In vitro test is pointed out, retinoic acid, the interferon-induced macrophage activity of the same inhibition of retinol, if add carrotene in the culture, this inhibition is reversed, the oxygen injury that causes in the process in inflammation can make the macrophage receptor decreased number, and in vivo studies proves, carrotene and canthaxanthin interaction energy together suppress the macrophage membrane receptor that active intermediate product causes and lose.
2, remove free radical: oxygen radical is the one of the main reasons that causes tumour, aging, angiocardiopathy, and the unique biological activity of carrotene is an oxygen radical " street cleaner " in the body, thereby plays anti-cancer, antidotal important function.
(9) iron (Fe), iron are the maximum a kind of trace elements of people's in-vivo content, and total amount is about 4-5 gram in human body, and wherein 60%-70% is with hemoglobin, and 3% with myoglobins, and the form of 1% iron enzyme exists, and all the other 30% exists with the form of stocking iron.Stocking iron mainly is present in the reticuloendothelial system of liver, spleen and bone with the form of iron oxide red albumen.
Physiological function: the formation that 1, participates in enzyme: iron participates in some metalloenzyme or activates the confactor of some metalloenzyme, transports in vivo in oxygen and the intracellular electronics transmission to play a role.Known more than ten kinds of iron enzymes or iron rely on enzyme at present.Oxidation as atriphos in the mitochondria (ATP) generates the effect that just comprises many iron enzymes, and these enzymes pass through the oxidation of process iron in respiratory chain and reduce alternately, and the function of conveying electronic and storage power is arranged; And catalase, peroxidase, monoamine oxidase etc. all participate in the many metabolic processes of body (synthetic as DNA, catecholamine metabolism etc.).
2, keep body's immunity: it is essential that enough iron is taken in keeping immune normal function.Iron can strengthen killing and wounding of neutrophil leucocyte and phagocytic function, safeguards T cell, B cell proliferation, differentiation and production of antibodies, so iron deficiency can influence humoral immunity and cellular immunity.Iron deficiency person's circulation T lymphocyte concentration descends, and NK (NK) is active to be reduced.Scientific research finds that iron deficiency the elderly's immunocompetence is lower than the normal the elderly of iron.This is that the T cell content that plays the control regulating action in the immune system will descend, thereby causes immune system to operate because the iron content in the human body is when not enough.According to another report, iron can activate plurality of enzymes.When asiderosis, ribonuclease activity reduces, liver, spleen and thymus protein matter are synthetic to be reduced, it is various unusual that immunologic function is occurred, as the GALT atrophy, thymic lymphocytes and periphery blood T cell reduce, and the T lymphopoiesis can form cell (PFC) generation macrophage and NK (NK) function all is subjected to press down.
Asiderosis can interference cell in the effect of ferrous metal enzyme.The activity of iron content ribonucleic acid reductase, reduction can make the synthetic peroxide of phagocyte reduce, so that influence the sterilizing power of these cells.
3, synthetic hemoglobin and myoglobins: in the iron compound of biological function was arranged, main was hemoglobin.The structure of 4 ferrohemes and 4 globulin chains provides a kind of effective mechanism in the hemoglobin, can combine with oxygen and don't oxidized, is playing key effect in the process from the lung delivering oxygen to tissue.
Myoglobins is that 1 ferroheme and 1 globulin chain are formed, and exists only in the musculature, and basic function is to carry in muscle and storage oxygen.
4, anti-anoxic: because after the Plain enters the plateau, hematopoiesis function is hyperfunction, the red blood cell increase helps the transportation and the acclimatization to anoxia of oxygen, iron is the important component of erythrocyte and hemoglobin, the transhipment and the exchange process of oxygen and carbon dioxide in participating in organizing play a part that oxygen is transported to muscle and cell goes.Therefore, iron has the effect of anti-anoxic
In addition, iron also has the anaemia of control, antifatigue, strengthens functions such as memory.
Asiderosis; Lack iron and can cause hypoferric anemia, blood red ball reduces, and physical efficiency descends, and locomitivity is poor; Iron participates in metabolism reaction, delicate adjusting whole organ physiological activity.Asiderosis also can constitute influence to brain, the iron enzyme in the cell of brain is descended, and then influence cellular oxidation metabolic response and nerve conduction material, and the result causes abnormal behavior, symptoms such as feeblemindedness, absent minded, poor memory.
(10) zinc (Zn) zinc is that the trace that body weight for humans is wanted does not have one of element, mainly be present in the organs such as bone, tooth, skin, muscle, and be height especially with retina, prostate.Zinc relates to each aspect of organism metabolism, and what comprise inhereditary material transcribes and duplicate with health and disease closely related, and zinc is the confactor of 100 plurality of enzymes in the body, also is the constituent of protein, hormone and nucleotides.
Physiological function: 1, promote hormone secretion: zinc is in the generation of some hormone, in storage and the secretion effect is arranged all, reaction to hormone receptor usefulness and cell produces significant impact, generation as insulin just needs a kind of zinc enzyme, be called protaminase, and insulin usually is present in the pancreas with the insulin zinc form, and it can delay and prolong the insulin for reducing blood sugar effect.Zinc can also change insulin solubility, influences the release of insulin.
2, improve immunity: zinc is in close relations to immunologic function, and zinc can activate more than 200 kind of hormone and enzyme that life is played an important role, helps the maximum function of immune system performance, improves the vigor ability of spermatozoon, strengthens prostatic anti-infection ability.Scarce zinc can cause the immune system atrophy of thymus gland, the neutrophil leucocyte chemotactic is suppressed, cellular immunity and humoral immunity are all taken place unusually, lack the main lymphocytic function of T that influences of zinc, synthetic and the activity of thymosin extrasin, the thin function with the NK cell of lymph, the cytotoxicity that antibody dependent cellular mediates, the generation of lymphokine and cytophagous function etc.Children lack zinc and show as the lymphocyte minimizing, atrophy of thymus gland, tardy allergic reaction ability weaken, wound healing delays, the pathogenic microorganism easy infection is increased, many clinical case immunologic functions reduce relevant with zinc deficiency, and autoimmune disease patient blood zinc is lower than normally mostly.
There are some researches show that when flu takes place an amount of zinc supplementation can be shortened the course of disease, promotes body recovery.
3, delay senility: a major reason of human senility is that body produces a large amount of free radicals.These free radicals be if can not in time be eliminated, bulk deposition in vivo, and cause the cellular matrix oxidation, and form also disrupting biofilm of lipid peroxide (LPO) free radical, cause cell dead too early, thereby accelerate the aging of human organ.Nerve cell mortality meeting causes senile dementia, and dead skin cell and lipid peroxide form and cause senile plaque expelling etc.Zinc can be removed the free radical process that delays senility.
In addition, zinc also has and promotes to grow and multiple function such as brain growth.
Zinc deficiency: lacking relevant disease of zinc such as cardiovascular system, hemopoietic system, excretory system etc. has substantial connection.
Ten, selenium (Se), selenium are a kind of electronegative nonmetallic ions.Be micro elements needed by human, be distributed widely in human body except that fat in a organized way in, with liver, pancreas, stomach, heart spleen and nail for the highest.Selenium concentration in the blood of human body differs.It is subjected to living environment, the influence of Se content in soil, water and the food, and selenium has multiple function in vivo.
Physiological function: 1, anti-oxidant, the antioxidation of selenium can be protected the integrality of cell membrane, removes free radical, anti-ageing.Because human body cell contains a kind of unrighted acid, oxidation reaction takes place in containing the more tissue of oxygen easily, generate lipid peroxide.And lipid peroxide is accumulated in human body and can be caused physiological function to descend, and liver, lung, cardiovascular damage also quicken human senility speed simultaneously, and occurring as senile plaque expelling is exactly the result of skin histology accumulation lipid peroxide.Selenium has the effect of decomposing MDA in vivo as the constituent of glutathione oxidase, thereby the protection biological cell is avoided destroying; keep the cell normal function; the protection body tissue is avoided free-radical oxidation and is destroyed, and removes free radical, thereby has anti-ageing.
2, strengthen immunologic function: selenium has the lymphocyte of stimulation and immunoglobulin (Ig) produces antibody, and the haematogenic immunity globulin levels is raise, and strengthens body produces antibody to vaccine or other antigen ability.Selenium can also strengthen lymphocyte transformation and delayed allergy, and lymphocyte can promote cytophagous function to mitogen IR ability drop and mend selenium when lacking selenium.Therefore, selenium can improve human immunocyte and humoral immune function, strengthens the resistance of body to disease.Studies show that some the elderlys take the enzyme preparation after 6 months that contains 100 micrograms every day, their immune full recovery is to young level.
3, antiviral: international current research shows, selenium is the nutrient that unique and virus infections have direct relation.An amount of Selenium Supplement can be prevented and the enantiopathy viral disease.Recently statistics shows, when human body lacks selenium, infects the dangerous obviously increase of highly pathogenic viral disease.As influenza virus, common cold virus, AIDS virus, variola virus and hepatovirus all have similar sensitivity to dye to lacking selenium.Selenium can promote T lymphocyte and neutrophil leucocyte propagation and killing action, promotes the synthetic and antibody of immunoglobulin (Ig) to generate, and strengthens the ability of body disease-resistant poison, suppresses complement activation, alleviates the immunologic mjury that immune complex causes.Selenium can also suppress the activation of AIDS virus, prevents Apoptosis.U.S. Miami University studies have shown that the HIV-positive who has optimum activity with selenoenzyme in the body compares, and the death rate that lacks the HIV-positive of selenium in the body will exceed more than 20 times.
4, cancer-resisting: selenium is the very capable trace element of anti-cancer.A large amount of experimental results show that, selenium has the two-way function that promotes differentiation and suppress division to cancer cell, can also adjust the expression of propagation and split gene, make the cancer cell behavior to normal conversion, simultaneously can suppress to change the activity of closely-related protein kinase C with cancer cell, thereby the protein that suppresses effectively in the cancer cell is synthetic, dna replication dna and growth of cancer cells.A large amount of clinical data checkings, the height of the blood selenium level of cancer patient is significantly positive negative correlation with pathogenesis of cancer.
New York the scholar prove, satisfying under the situation of nutritional need, replenishes 200 microgram selenium every day immunologic function is had significant spread effect, and the growing amount of T lymphocyte and neutrophil leucocyte can roll up.This bacterium suppresses to have tumoricidal effect.According to epidemiology survey, to mend selenium and can reduce prostate cancer, having an effect of lung cancer and liver cancer is the most obvious.
The anti-cancer experiment that University of Arizona carries out shows, take every day among the crowd of 200 microgram selenium preparations, the cancer general mortality rate reduces by 50%, total incidence reduces by 37%, the incidence of disease of prostate cancer reduces by 63%, and the colon cancer incidence of disease has reduced by 53%, and the lung cancer morbidity rate reduces by 46%, especially when beginning to experimentize to after the minimum people's Selenium Supplement of selenium concentration in the body, this antitumaous effect is more obvious.
5, eliminate heavy metal of body: selenium is a kind of electronegative nonmetallic ion, can combine with the metal ion of positively charged load in human body, and metal ions such as the aluminium that brings out virus, mercury, copper are excreted.
In addition, selenium also has cardiovascular, liver and eyes of protection and improves multiple function such as diabetic symptom.
Lack selenium: selenium deficiency can cause human body stagnations of growing, and hypoimmunity palpitaition, breathes hard and feels sick and alopecia, piptonychia, part patient skin can occur and demonstrate,prove shape, nervous symptoms, tooth infringement etc.
In sum, this sour milk tablet has anti-bacteria and anti-virus, anti-infective, raising immunity of organisms, functions such as preventing cold, influenza.
The manufacture craft of this sour milk tablet is:
1, pretreatment of raw material: fresh high-quality yak milk, purification process after filtration.
2, allotment mixes: earlier liposoluble vitamin E, beta carotene are dissolved in the garlic oil, then in the milk of the yak after fructose, beta glucan, zinc gluconate, ferrous lactate, Se-enriched yeast, stachyose etc. add purification, and dissolve stirring fully, to obtain uniform batch mixes emulsion.
3, the homogeneous sterilization concentrates, and the consumption milk that will mix earlier is heated to the 90-100 degree again after being preheating to 60-70 degree homogeneous, and 3-5 minute sterilization processing sent into to remain in the vacuum decker about 45 degree and be concentrated into milk solids thing content 45%.
4, inoculation fermentation: the allotment of (1) leavening: the weight ratio of lactobacillus bulgaricus and streptococcus lactis is 1: 3-5.(2) inoculation fermentation is cooled to 45 degree with the mixed emulsion after concentrating, and adds the leavening of 1-3%, and temperature remains on 45 degree, and PH4.5-4.7 stirred 10 minutes, ferments, and stops fermentation when fermenting acidity reaches 50-60%.Form during for fear of spraying and solidify, add the slow neutralization of 5% alkali lye and make acidity be lower than 55%.
5, spray-drying: use high-pressure spray-drying machine (homogenization pressure 14.7-19.6MPa) to reach homogeneous and spray-drying dual purpose, the spray tower temperature keeps about 45 degree, and wherein EAT is 100 degree, and temperature of outgoing air is 45 degree.
6, secondary mixes: remain the vitamin C and the immunoglobulin (Ig) that are subject to high temperature destruction in will preparing burden and add dried yak sour milk powder, and fully mix.
7, compressing tablet check bag mixes the yak sour milk powder with secondary and carries out compressing tablet at tablet press machine, and tablet press machine pressure is controlled at 0.3-0.35MPa and is pressed into sheet, pack after the assay was approved formal product.
It is for the good yoghurt that ferments that preliminary treatment is checked and accepted in the standardization of yak milk, and the process of required quality raw materials is provided, and allotment mixes, and is the raw material in the prescription to be dissolved respectively by its physicochemical property mix the operation that stirs.The homogeneous sterilization is in order to reduce the microorganism total amount to the process that can not endanger the leavening growth of microorganism.The inoculation fermentation operation is the process of adding leavening in the batch mixes emulsion according to a certain percentage, fermentation procedure is the mixed emulsion that has added leavening, become the process of sour milk at the preference temperature environment bottom fermentation of regulation, this operation is converted into lactic acid with lactose, form tart flavour and get liquid yogurt, spray-drying is that the liquid yogurt that ferments is sent into the high-pressure spray-drying machine, and spray-drying becomes the process of sour milk powder under the temperature and pressure of regulation.The secondary mixed processes is to destroy nutritional labeling for minimizing is subject to high temperature, guarantees the process of this product quality.Sheeting process is the process that the sour milk powder that preceding operation makes is pressed into sheet under the pressure of regulation.This operation gets the semi-finished product sour milk tablet, and test package is with the semi-finished product sour milk tablet, and by state quality standard, after the assay was approved, packing becomes the process of formal product.
Six, quality standard:
1, physical and chemical index:
| Sour milk powder | g/100g | 81 |
| Immunoglobulin (Ig) | g/100g | 1.8 |
| Beta glucan | g/100g | 3 |
| Garlic oil | g/100g | 3.6 |
| Vitamin C | g/100g | 1.5 |
| Cobastab 6 | mg/100g | 9 |
| Vitamin E | mg/100g | 45 |
| Beta carotene | mg/100g | 24 |
| Iron | mg/100g | 45 |
| Zinc | mg/100g | 36 |
| Selenium | mg/100g | 0.22 |
| Stachyose | g/100g | 9 |
2, instructions of taking: every day three times, every 8-10 gram, children's all subtracts, and this product contains sour milk, immunoglobulin (Ig), garlic oil, beta glucan, vitamin C, Cobastab
6, active ingredients such as vitamin E, beta carotene, iron, zinc, selenium, have antiviral, anti-infective, improve immunity preventing cold, functions such as influenza.And have a sour-sweet flavor of sour milk, smooth mouthful of garden.
Seven, the specific embodiment:
Embodiment: get 92.1 kilograms of bright yak milk, 3 kilograms of leavenings, yeast 50 grams, 0.252 kilogram of immunoglobulin (Ig), 0.52 kilogram of garlic oil, 0.42 kilogram of beta glucan, vitamin C 0.21 thousand, vitamin E 6.3 grams, Cobastab
61.26 1.26 kilograms of grams, beta carotene 3.4 gram, ferrous lactate 35 grams, zinc gluconate 40.5 grams, Se-enriched yeast 0.25 gram, stachyose.
Preliminary treatment is filtered in the standardization of bright yak milk, and earlier with liposoluble vitamin E, beta carotene is dissolved in the garlic oil, then with fructose, beta glucan, Cobastab
6Ferrous lactate, zinc gluconate, Se-enriched yeast, stachyose adds mixed dissolution in the yak milk together, and fully stir homogeneous, mixed emulsion is preheating to 65 degree, 1.6MPa and after carrying out two matter homogeneous under the 2.5MPa pressure, after being heated to the sterilization in 5 minutes of 100 degree again, send into vacuum decker and remain on 45 degree, be concentrated into and contain milk solids thing 45%, emulsion after concentrating is cooled to 45 degree, add 3% leavening and remain on 45 degree, PH4.6 stirs and fermented in 10 minutes, fermenting acidity reaches 55% and stops fermentation, form during for fear of spray-drying and solidify, the alkali lye of adding 5% slowly neutralizes, make acidity low 55% then the liquid yogurt that ferments be sent into the high-pressure spray-drying machine and carry out drying (homogenization pressure 14.7-19.6MPa) to reach spray-drying, the double action of homogeneous, the spray-drying temperature remains on 45 degree, its EAT 100 degree, temperature of outgoing air 45 degree spray-dryings become sour milk powder, to be subject to the immunoglobulin (Ig) that high temperature destroys again, vitamin C adds in the dried sour milk powder and mixes, and the sour milk powder after stirring is sent into the tablet press machine compressing tablet, 0.3-0.35MPa is pressed into sheet in the control of tablet press machine pressure, this operation gets the semi-finished product sour milk tablet, by state quality standard after the assay was approved, packing becomes formal product.
Claims (2)
1, the sour milk tablet manufacture craft is characterized by: bright consumption milk standardised filtration, purification, and the allotment homogeneous, sterilization concentrates, inoculation fermentation, spray-drying, secondary mixing preparation, compressing tablet test package.
2, making the sour milk tablet process conditions is characterized by: the preliminary treatment of bright consumption milk is filtered and is purified, and earlier liposoluble vitamin E6.3 gram, beta carotene 3.4 grams is dissolved in garlic oil, then with 1.2 kilograms in fructose, Cobastab
61.26 1.26 kilograms of grams, ferrous lactate 35 gram, zinc gluconate 40.5 grams, Se-enriched yeast 0.25 gram, stachyose etc. add in the milk mixed dissolution together and stir.Then will mix emulsion and be preheating to the 60-70 degree, 1.6MPa and twin-stage homogeneous under the 2.5MPa pressure, be heated to the sterilization in 5 minutes of 100 degree again, send in the true thickener and to keep 45 degree to be concentrated into containing solids 45%, emulsion after concentrating is cooled to 45 degree, add 3% leavening PH4.5-4.7 stirring fermented in 10 minutes, acidity reaches 50%-60% and stops fermentation, form during for fear of spray-drying and solidify, add 5% alkali lye and slowly neutralize, make acidity be lower than 55%, then the liquid yogurt that ferments is sent into high pressure, spray dryer drying (homogenization pressure 14.7-19.6MPa) is to reach spray-drying and homogeneous double action, the spray tower temperature remains on about 45 degree, its EAT 100 degree, temperature of outgoing air 45 degree, spray-drying becomes sour milk powder, to be subject to the immunoglobulin (Ig) that high temperature destroys again, vitamin C adds in the sour milk powder and mixes, and stirs, and compressing tablet pressure increases the weight of to be controlled at 0.3-0.35MPa and is pressed into sheet, after the assay was approved, packing composition formal product.
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| CN 200610084964 CN1895066A (en) | 2006-05-31 | 2006-05-31 | Anti-body leben tablet (powder) |
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| CN 200610084964 CN1895066A (en) | 2006-05-31 | 2006-05-31 | Anti-body leben tablet (powder) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101361505B (en) * | 2008-09-12 | 2010-12-15 | 华南理工大学 | Sour milk powder preparation method by spray drying |
| CN101283703B (en) * | 2008-05-13 | 2011-05-18 | 孟克 | Preparation method of full scream fermented mares milk powder |
| CN102511556A (en) * | 2011-12-08 | 2012-06-27 | 内蒙古伊利实业集团股份有限公司 | Milk tablet and its preparation method |
| CN105558011A (en) * | 2015-12-16 | 2016-05-11 | 新希望双喜乳业（苏州）有限公司 | Set-style yoghurt capable of enhancing organism immunity and preparation method thereof |
| CN106070645A (en) * | 2016-06-29 | 2016-11-09 | 北京本草通汇科技中心 | Pure yak milk slice and processing technique thereof |
| CN106343015A (en) * | 2016-08-31 | 2017-01-25 | 和政县华龙乳制品有限公司 | Preparation method of high-activity viable bacteria type yak milk solid yoghourt |
| CN112042756A (en) * | 2020-09-16 | 2020-12-08 | 甘肃华羚乳品股份有限公司 | Chitosan oligosaccharide yak milk yoghurt tablet and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101283703B (en) * | 2008-05-13 | 2011-05-18 | 孟克 | Preparation method of full scream fermented mares milk powder |
| CN101361505B (en) * | 2008-09-12 | 2010-12-15 | 华南理工大学 | Sour milk powder preparation method by spray drying |
| CN102511556A (en) * | 2011-12-08 | 2012-06-27 | 内蒙古伊利实业集团股份有限公司 | Milk tablet and its preparation method |
| CN105558011A (en) * | 2015-12-16 | 2016-05-11 | 新希望双喜乳业（苏州）有限公司 | Set-style yoghurt capable of enhancing organism immunity and preparation method thereof |
| CN106070645A (en) * | 2016-06-29 | 2016-11-09 | 北京本草通汇科技中心 | Pure yak milk slice and processing technique thereof |
| CN106343015A (en) * | 2016-08-31 | 2017-01-25 | 和政县华龙乳制品有限公司 | Preparation method of high-activity viable bacteria type yak milk solid yoghourt |
| CN112042756A (en) * | 2020-09-16 | 2020-12-08 | 甘肃华羚乳品股份有限公司 | Chitosan oligosaccharide yak milk yoghurt tablet and preparation method thereof |
| EP4046632A1 (en) * | 2021-02-23 | 2022-08-24 | DMC Research Center, S.L. | Propyl propane thiosulfonate for use in the treatment of cancer |
| WO2022179714A1 (en) * | 2021-02-23 | 2022-09-01 | Dmc Research Center, Sl | A propyl propane thiosulfonate compound for use as antitumoral |
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