CN1891215A - 对器质性脑损伤引起的高级脑功能下降具有改善作用的组合物 - Google Patents
对器质性脑损伤引起的高级脑功能下降具有改善作用的组合物 Download PDFInfo
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- CN1891215A CN1891215A CNA2006100996855A CN200610099685A CN1891215A CN 1891215 A CN1891215 A CN 1891215A CN A2006100996855 A CNA2006100996855 A CN A2006100996855A CN 200610099685 A CN200610099685 A CN 200610099685A CN 1891215 A CN1891215 A CN 1891215A
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Abstract
Description
Claims (20)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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JP2005-191624 | 2005-06-30 | ||
JP2005191624 | 2005-06-30 | ||
JP2005191624A JP5697293B2 (ja) | 2005-06-30 | 2005-06-30 | 器質的脳障害に起因する高次脳機能の低下に対する改善作用を有する組成物 |
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CN201410745897.0A Division CN104666290A (zh) | 2005-06-30 | 2006-06-29 | 对器质性脑损伤引起的高级脑功能下降具有改善作用的组合物 |
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CN1891215A true CN1891215A (zh) | 2007-01-10 |
CN1891215B CN1891215B (zh) | 2015-08-19 |
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CN201410745897.0A Pending CN104666290A (zh) | 2005-06-30 | 2006-06-29 | 对器质性脑损伤引起的高级脑功能下降具有改善作用的组合物 |
CN200610099685.5A Expired - Fee Related CN1891215B (zh) | 2005-06-30 | 2006-06-29 | 对器质性脑损伤引起的高级脑功能下降具有改善作用的组合物 |
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CN201410745897.0A Pending CN104666290A (zh) | 2005-06-30 | 2006-06-29 | 对器质性脑损伤引起的高级脑功能下降具有改善作用的组合物 |
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US (2) | US20090048215A1 (zh) |
EP (1) | EP1896136A2 (zh) |
JP (1) | JP5697293B2 (zh) |
KR (1) | KR101344053B1 (zh) |
CN (2) | CN104666290A (zh) |
AU (1) | AU2006266751B2 (zh) |
CA (1) | CA2613343C (zh) |
RU (1) | RU2008103363A (zh) |
WO (1) | WO2007004685A2 (zh) |
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JP2003048831A (ja) | 2001-08-02 | 2003-02-21 | Suntory Ltd | 脳機能の低下に起因する症状あるいは疾患の予防又は改善作用を有する組成物 |
JP4993852B2 (ja) | 2004-09-17 | 2012-08-08 | サントリーホールディングス株式会社 | ストレスに起因する行動異常を伴う症状あるいは疾患の予防又は改善作用を有する組成物 |
JP5967855B2 (ja) | 2005-06-30 | 2016-08-10 | サントリーホールディングス株式会社 | 日中活動量の低下および/又はうつ症状の改善作用を有する組成物 |
US8383677B2 (en) | 2006-12-28 | 2013-02-26 | Suntory Holdings Limited | Nerve-regenerating agent |
WO2009002148A1 (en) | 2007-06-27 | 2008-12-31 | N.V. Nutricia | Food composition for prodromal dementia patients |
ES2808406T3 (es) | 2007-06-26 | 2021-02-26 | Nutricia Nv | Mejora de la memoria en sujetos con un mini examen del estado mental de 24-26 |
WO2009002146A1 (en) | 2007-06-26 | 2008-12-31 | N.V. Nutricia | Supporting activities of daily living |
WO2009002145A1 (en) | 2007-06-26 | 2008-12-31 | N.V. Nutricia | Lipid composition for improving function of brain functioning |
JP2009019025A (ja) * | 2007-07-13 | 2009-01-29 | Suntory Ltd | 非ヒト動物の老化又は痴呆に伴う疾患又は症状の改善剤 |
US8343753B2 (en) | 2007-11-01 | 2013-01-01 | Wake Forest University School Of Medicine | Compositions, methods, and kits for polyunsaturated fatty acids from microalgae |
EP2609812B1 (en) | 2007-12-20 | 2018-08-29 | N.V. Nutricia | Liquid nucleotides/nucleosides-containing product |
US20110082205A1 (en) * | 2009-10-01 | 2011-04-07 | Panker Cynthia A | Docosahexaenoic Acid Gel Caps |
EP2488190B1 (en) * | 2009-10-13 | 2017-09-20 | DSM IP Assets B.V. | Reducing the risk of pathological effects of traumatic brain injury |
JP6375296B2 (ja) * | 2013-07-10 | 2018-08-15 | ライオン株式会社 | 脳機能改善用内服組成物、脳内アミロイドβ蓄積抑制用内服組成物、脳機能改善用食品組成物及び脳内アミロイドβ蓄積抑制用食品組成物 |
US9216199B2 (en) | 2013-12-05 | 2015-12-22 | Buriva, LLC | Nutritional supplement containing phospholipid-DHA derived from eggs |
US9549937B2 (en) | 2013-12-05 | 2017-01-24 | Burvia, LLC. | Composition containing phospholipid-DHA and folate |
US9610302B2 (en) | 2013-12-05 | 2017-04-04 | Buriva, LLC. | Composition containing phospholipid-DHA and B vitamins |
US9233114B2 (en) | 2013-12-05 | 2016-01-12 | Buriva, LLC | Dietary supplement containing phospholipid-DHA derived from eggs |
US10456368B2 (en) | 2016-09-26 | 2019-10-29 | Garrett E. Wdowin | Compositions for mitigating brain trauma and methods thereof |
US20230398088A1 (en) * | 2020-10-30 | 2023-12-14 | The Trustees Of The University Of Pennsylvania | Lipid Prophylactic Brain Injury Treatment |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4668704A (en) * | 1982-08-09 | 1987-05-26 | Regents Of The University Of California | Method for protecting and healing gastro-duodenal mucosa and the liver of mammals |
US4526902A (en) * | 1983-10-24 | 1985-07-02 | Century Laboratories, Inc. | Combined fatty acid composition for treatment or prophylaxis of thrombo-embolic conditions |
US5198468A (en) * | 1987-06-24 | 1993-03-30 | Efamol Holdings Plc | Essential fatty acid composition |
AU683027B2 (en) * | 1993-01-27 | 1997-10-30 | Scotia Holdings Plc | Triglycerides |
US5583019A (en) * | 1995-01-24 | 1996-12-10 | Omegatech Inc. | Method for production of arachidonic acid |
US6080787A (en) * | 1997-02-21 | 2000-06-27 | Abbott Laboratories | Methods for reducing the incidence of necrotizing enterocolitis |
FR2762993B1 (fr) * | 1997-05-06 | 1999-08-13 | Inst Rech Biolog Sa | Nouvelle utilisation de phospholipides d'origine animale en therapeutique et/ou dietetique |
US5902807A (en) * | 1997-05-12 | 1999-05-11 | Antti Haapalinna | Method for the treatment of mental illness in mammals and a composition therefor |
EP0893064B1 (fr) * | 1997-07-22 | 2003-01-15 | Societe Des Produits Nestle S.A. | Composition lipidique pour formule infantile et procédé de préparation |
US6225444B1 (en) * | 1998-02-10 | 2001-05-01 | Protarga, Inc. | Neuroprotective peptides and uses thereof |
JP2000239168A (ja) * | 1999-02-19 | 2000-09-05 | Bizen Kasei Kk | 脳卒中予防剤およびこれを配合してなる組成物 |
US7208180B2 (en) * | 2000-05-08 | 2007-04-24 | N.V. Nutricia | Method and preparation for the preventing and/or treating vascular disorders and secondary disorders associated therewith |
JP2003048831A (ja) * | 2001-08-02 | 2003-02-21 | Suntory Ltd | 脳機能の低下に起因する症状あるいは疾患の予防又は改善作用を有する組成物 |
EP1413315A4 (en) * | 2001-08-03 | 2006-08-16 | Takeda Pharmaceutical | DRUGS WITH CONTINUOUS RELEASE |
US6689810B2 (en) * | 2001-08-21 | 2004-02-10 | Cellular Sciences, Inc. | Method for treating pulmonary disease states in mammals by altering indigenous in vivo levels of nitric oxide |
NZ548508A (en) * | 2002-05-03 | 2008-04-30 | Pronova Biocare As | Use of EPA and DHA in preventing cerebral damage wherein the dosage ranges from 0.5 to 5.0g of EPA and/or DHA daily |
CN100418519C (zh) * | 2002-09-24 | 2008-09-17 | 三得利株式会社 | 用于增强认知能力的含有花生四烯酸或其与二十二碳六烯酸的组合的组合物 |
WO2004091663A1 (ja) * | 2003-04-18 | 2004-10-28 | Kyowa Hakko Kogyo Co., Ltd. | 神経再生薬 |
IL158552A0 (en) * | 2003-10-22 | 2004-05-12 | Enzymotec Ltd | Lipids containing omega-3 fatty acids |
JP4522075B2 (ja) * | 2003-10-29 | 2010-08-11 | サントリーホールディングス株式会社 | 血管の老化に起因する症状あるいは疾患の予防又は改善作用を有する組成物 |
AU2005208832A1 (en) * | 2004-01-19 | 2005-08-11 | Martek Biosciences Corporation | Reelin deficiency or dysfunction and methods related thereto |
JP2006083136A (ja) * | 2004-09-17 | 2006-03-30 | Suntory Ltd | ストレスに起因する脳機能の低下およびそれに伴う症状あるいは疾患の予防又は改善作用を有する組成物 |
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CN104666290A (zh) | 2015-06-03 |
WO2007004685A2 (en) | 2007-01-11 |
RU2008103363A (ru) | 2009-08-10 |
US20090048215A1 (en) | 2009-02-19 |
KR101344053B1 (ko) | 2013-12-24 |
JP2007008863A (ja) | 2007-01-18 |
AU2006266751B2 (en) | 2012-08-23 |
CN1891215B (zh) | 2015-08-19 |
EP1896136A2 (en) | 2008-03-12 |
US20150133555A1 (en) | 2015-05-14 |
AU2006266751A1 (en) | 2007-01-11 |
JP5697293B2 (ja) | 2015-04-08 |
KR20080026572A (ko) | 2008-03-25 |
CA2613343C (en) | 2015-06-02 |
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