CN1889861B - Inhaler for basic pharmaceutical agents and method for production thereof - Google Patents

Inhaler for basic pharmaceutical agents and method for production thereof Download PDF

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Publication number
CN1889861B
CN1889861B CN 200480036187 CN200480036187A CN1889861B CN 1889861 B CN1889861 B CN 1889861B CN 200480036187 CN200480036187 CN 200480036187 CN 200480036187 A CN200480036187 A CN 200480036187A CN 1889861 B CN1889861 B CN 1889861B
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China
Prior art keywords
inhalation
formulation
device according
inhalation device
acid
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CN 200480036187
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Chinese (zh)
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CN1889861A (en
Inventor
买买提·萨梅特
伊夫-托尔斯滕·普日贝拉
克里斯托夫·施米茨
卡琳·路德维希
米迦勒·霍斯特曼
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Lts罗曼治疗方法有限公司
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Priority to DE2003156925 priority Critical patent/DE10356925B4/en
Priority to DE10356925.1 priority
Application filed by Lts罗曼治疗方法有限公司 filed Critical Lts罗曼治疗方法有限公司
Priority to PCT/EP2004/012947 priority patent/WO2005053444A1/en
Publication of CN1889861A publication Critical patent/CN1889861A/en
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Publication of CN1889861B publication Critical patent/CN1889861B/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • AHUMAN NECESSITIES
    • A24TOBACCO; CIGARS; CIGARETTES; SMOKERS' REQUISITES
    • A24FSMOKERS' REQUISITES; MATCH BOXES
    • A24F47/00Smokers' requisites not provided for elsewhere, e.g. devices to assist in stopping or limiting smoking
    • A24F47/002Simulated smoking devices, e.g. imitation cigarettes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0001Details of inhalators; Constructional features thereof
    • A61M15/0003Details of inhalators; Constructional features thereof with means for dispensing more than one drug
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/06Inhaling appliances shaped like cigars, cigarettes or pipes

Abstract

The invention relates to a device, for the administration of basic agents, in particular nicotine, to the human or animal body, by means of inhalation, comprising a first preparation containing nicotine base or/and a further basic agent and, furthermore, a second or further preparations, whereby at least one preparation contains at least one volatile acid suitable for inhalation.

Description

碱性药物吸入器及其制造方法 Basic drug inhaler and a method for producing

技术领域 FIELD

[0001] 本发明涉及通过吸入的方式给予人或动物体碱性活性物质、特别是尼古丁的装置。 [0001] The present invention relates to administering to a human or animal body basic active substance by inhalation manner, in particular nicotine device. 本发明进一步涉及可以得到该装置的制造方法,以及所述的装置用于戒烟或在必要的情况下用于渴望尼古丁的无烟满足的应用。 The present invention further relates to a method of manufacturing the device can be obtained, and said means for applying for smoking cessation or nicotine to satisfy the desire in if necessary.

背景技术 Background technique

[0002] 多年以来,借助于吸气中吸入的空气给予尼古丁的尼古丁吸入器已是众所周知的(如美国专利4 917 120和美国专利5 167 242)。 [0002] Over the years, the intake air sucked by means of administering nicotine Nicotine inhalers are well known (e.g., U.S. Patent No. 4,917,120 and U.S. Patent No. 5,167,242). 多年来,尼古丁吸入器也已在几个欧洲国家的市场上作为戒烟产品可以得到(〃 Nicorette ® “ ;Pharmaci/辉瑞)。然而,由于用后一种吸入器,吸入时只有少量的尼古丁变得有效,所以该装置没有得到广泛使用。这特别是由于已知吸入器技术的基本缺陷和用这些技术可以达到的耐受性。特别地,由尼古丁的碱性导致的对呼吸道粘膜的局部刺激作用是不利的,因为这种刺激作用引起急迫的咳嗽,其导致由吸入器释放的尼古丁蒸气的吸收减少。这样只有非常少量的尼古丁被身体吸收。 Over the years, nicotine inhalers have been available as a smoking cessation product (〃 Nicorette ® "; Pharmaci / Pfizer) on the market in several European countries. However, due after using an inhaler inhalation only a small amount of nicotine becomes effective, so the apparatus is not widely used. local stimulation of the respiratory mucosa particularly because substantially defect known inhaler technology and can be achieved using these techniques tolerance. in particular, the basic cause of nicotine is disadvantageous because of this urgent cause irritation cough, which is caused by the release of nicotine vapor inhaler reduce the absorption so that only a very small amount of nicotine absorbed by the body.

发明内容 SUMMARY

[0003] 所以本发明的目的是提供一种尼古丁吸入器,该吸入器使尼古丁能够经呼吸道吸收,而引起尽可能小的刺激和尽可能深入的吸收。 [0003] Therefore, object of the present invention is to provide a nicotine inhaler, which enables the nicotine intake can be absorbed through the respiratory tract, cause as little irritation as possible and absorption depth.

[0004] 该目的是根据独立权利要求和其附属权利要求的装置,以及根据权利要求19和其附属权利要求的制备方法实现的。 [0004] This object is achieved according to the independent apparatus claim and its dependent claims, and the realization of the production method according to claim 19 and its subsidiary claims.

[0005] 因此,根据本发明的装置特征在于,该装置包括含有尼古丁碱或/和其它挥发性、 可吸入的碱性活性物质的第一制剂,且其进一步包括第二制剂或多个其它制剂,所述的第二制剂或所述的其它制剂中的至少一个含有至少一种可挥发及适于吸入的酸。 [0005] Thus, the device according to the present invention is characterized in that the apparatus comprises a base comprising nicotine and / or other volatile, first formulation inhalable basic active substance, and further comprising a second plurality of formulations or other formulations other formulation or said second formulation according to at least one and comprising at least one volatile acid suitable for inhalation. 所以,根据本发明的装置特征在于,吸入时,除了活性物质碱(如尼古丁碱)之外,还同时吸入了一种或多种挥发性酸化合物。 Therefore, according to the apparatus aspect of the present invention is that during inhalation, a base addition to the active substance (e.g. nicotine base), while further inhalation of one or more volatile acid compound.

[0006] 根据本发明的装置适于通过吸入的方式给予人或动物体碱性物质,尤其是尼古丁。 [0006] suitable for administration to a human or animal body by inhalation basic substance embodiment according to the present invention, in particular nicotine. 适当的碱性物质为,例如司来吉兰(selegiline)或/和美加明(mecamylamine) 0尼古丁和美加明的结合特别优选适用于戒烟。 Suitable basic substances, such as selegiline (of selegiline) and / or US mecamylamine (mecamylamine) 0 nicotine binding US mecamylamine is particularly preferably applied to smoking cessation.

[0007] 由于含有尼古丁碱(或其它活性物质碱)的第一制剂与含有挥发酸的另一制剂同时存在,所以吸入时尼古丁碱和挥发酸被挥发,从而导致碱和酸蒸气的混合物在该装置中形成相应的尼古丁盐(或其它活性物质碱相应的盐)。 [0007] Because of containing nicotine base (or other active substance base) a first formulation comprising a mixture of volatile acid is present in another formulation at the same time, so that during inhalation of nicotine base and volatile acid is volatilized, resulting in the base and the acid in the vapor means to form the corresponding nicotine salt (or other salt of the corresponding active substance bases). 该盐以液滴或微粒的形式随吸入空气进入呼吸道。 The salt form of droplets or particles with the intake air into the respiratory tract. 由于粘膜对盐的中性反应,所以与用已知的吸入装置可以达到的吸入相比, 这类吸入显示出更好的耐受性。 Since the reaction of the neutral salt mucosa, as compared with a known inhalation device can be achieved by inhalation, such suction exhibit better tolerance.

[0008] 关于这一点,优选所述的含有尼古丁碱的第一制剂,和含有酸的第二制剂在装置内分开的位置处使用。 [0008] For this position, a first preferred formulation of the nicotine base and a second acid-containing formulation in separate devices. 这样,可以设定空气进气道,从而在吸入时,一部分气流流经第一制剂,而另一部分气流流经第二制剂,且随后这两个气流(其中含有挥发的尼古丁碱和酸)合 Thus, the air intake can be set, so that during inhalation, air flows through a portion of the first agent, and another portion of air flow through the second formulation, and then these two streams (containing volatile nicotine base and acid) co

5并,然后可被吸入。 5 and then can be inhaled.

[0009] 吸入时,包含于第一制剂中的活性物质碱(如尼古丁碱)和包含于第二制剂中的挥发酸被动地挥发。 [0009] When inhaled, the active material comprising a base (e.g. nicotine base) a first formulation and a second formulation comprising a volatile acid passively evaporate. 可通过采用加热选择性地加速该过程;适用于该目的的方法对于本领域的技术人员是公知的。 The process may be accelerated by selective application of heat; methods suitable for this purpose to those skilled in the art are well known.

[0010] 当使用根据本发明的装置时,在流入的外界空气中形成气溶胶,尤其是当在蒸气中具有高浓度的活性物质碱和酸时。 [0010] When using the apparatus according to the present invention, an aerosol is formed in the outside air flowing in, especially when the active substance base and an acid having a high concentration in the vapor. 该气雾剂的形成是由于形成的尼古丁盐、盐混合物或盐液滴的较低的挥发性。 The aerosol is formed due to the lower volatility of the nicotine salts, salts or mixtures of salts formed droplets. 由于尼古丁不再以游离碱存在且不再经由外气相起到碱的作用, 所以形成的气溶胶同时也是显著提高耐受性的原因。 Since nicotine is no longer present and will not play the role of the base via the outer gas free base, the aerosol formation is also significantly improved tolerance reasons. 结果,只有气雾剂颗粒在肺泡的微粒沉积可以导致活性物质在肺中应用和吸收(再吸收)。 As a result, only the deposition of aerosol particles in the particulate active material can lead to the alveoli in the lung applications and absorption (reabsorption). 这些气雾剂小滴,或者作为部分溶于水的盐组分,或者作为固体分散物,由于中性(代替碱性的)粘膜反应,显示出远好于本领域中已知的装置可能显示出的耐受性。 These aerosol droplets, or as part of a water-soluble salt components, or as a solid dispersion, since the neutral (instead of basic) mucositis, exhibit far better in the means known in the art may show out of tolerance. 气溶胶形成是有益的,但对于实现根据本发明的治疗效果不是必不可少的。 Aerosol-forming is beneficial, but for achieving a therapeutic effect in accordance with the present invention is not essential. 总的来说,抑制气溶胶的形成的供给蒸气的高度稀释,在耐受性方面也是有用的。 In general, highly diluted steam is supplied to suppress aerosol formation, it is also useful in tolerability.

[0011] 通过根据本发明的吸入系统形成的气雾剂微粒的尺寸,最重要的是取决于气流的速度(流速)和混合区中各气态组分(分别为碱性活性物质和酸)的浓度。 [0011] by size of aerosol particles formed according to the intake system of the present invention, most importantly, on the gas flow velocity (flow rate), and each of the gaseous components in the mixing zone (basic active agent, respectively, and acid) concentration. 气雾剂微粒的尺寸低于10 μ m (平均直径),特别在5〜10 μ m内是有利于肺泡吸收的。 Size of aerosol particles less than 10 μ m (average diameter), in particular 5~10 μ m is beneficial alveolar absorption.

[0012] 根据优选实施方案,吸入装置包括第一进气孔,第二进气孔和出气孔。 [0012] According to a preferred embodiment, the inhalation device comprises a first inlet hole, and a second air intake vents. 设置这些孔以使流经第一进气孔的气流主要通过所述的第一制剂,且流经第二进气孔的气流主要通过所述的第二或其它制剂,这两个气流随后在其路径上合并,并经过所述的出气孔离开装置。 Apertures provided through the first inlet opening such that the main gas flow through said first formulation, and flowing through the second air intake port flow mainly through the second or other formulations, these two streams then the combined on its way, and after leaving the air outlet means.

[0013] 该装置进一步优选在其内具有长方形凹部、槽或沟,从而形成第一和第二进气道和出气道。 [0013] The apparatus preferably further has a rectangular recess, groove or grooves therein, thereby forming first and second inlet and outlet channels. 这些气流路径分别各通过所述的进气和出气口朝着外面开放。 The air flow path are respectively open toward the outside through each of the inlet and outlet. 所述的第一制剂设置于形成第一进气道的长方形凹部中,且所述的第二制剂设置于形成第二进气道的长方形凹部中。 A second formulation of a first formulation is provided in the rectangular concave portion is formed in the first intake port, and said concave portion is provided in a rectangular shape is formed in the second port. 优选将各制剂置于各自进气口的邻近处。 Each formulation is preferably placed in each intake port adjacent.

[0014] 通常,希望达到两个组分(活性物质碱、酸)的约等摩尔比值的摩尔蒸发速率。 [0014] Generally, to achieve the desired molar ratio of the rate of evaporation of about two moles of components (active substance base, acid) and the like. 正如所述,如果含有尼古丁的制剂和含有酸的制剂被放置于两个分开的进气道中,其具有结合的进气口,则可以控制各自的释放速率,尤其是通过两个槽中的流动条件的方式。 As described, if the formulation contains nicotine formulation containing an acid and is placed in two separate intake passage, an intake port having a combination of the respective release rates can be controlled, in particular a flow through two slots mode conditions. 例如, 可以设定流经第一开口和由此流经第一进气道的气流的释放速率为lOOyg/lOs ;在此情况下,如果使用醋酸作为酸组分,则大约50mg/10s的释放速率将适于所述的第二气流。 For example, the release rate can be set through the first opening and thereby the air flow through the first intake port is lOOyg / lOs; in this case, if acetic acid is used as the acid component, the release of about 50mg / 10s of the rate of the second gas stream is adapted.

[0015] 关于可得到的释放速率,优选在持续1〜10s、且其间达到0. 1〜11/min的吸气速度的一次吸气过程中,根据本发明的吸入装置从所述的制剂向吸入的空气中释放5〜 250 μ g,优选10〜100 μ g的尼古丁碱或另一碱性物质。 [0015] on the release rate is obtained, preferably in continuous 1~10s, intake velocity therebetween reaches 0. 1~11 / min during the next inhalation, the inhalation device according to the invention from a formulation according to intake air release 5~ 250 μ g, preferably 10~100 μ g nicotine base or another alkaline substance. 例如,在持续IOs且吸气速度在0. 1〜11/min之间的一次呼吸中,可以给予100 μ g的尼古丁碱;该释放速率适于治疗目的。 For example, IOs and the duration of a breath intake speed between 0. 1~11 / min can be given 100 μ g of nicotine base; the release rate is suitable for therapeutic purposes.

[0016] 为了尽可能少地削弱吸气过程,该装置优选具有贯穿其构造的大的通道横截面。 [0016] For inhalation weakened as little as possible, the apparatus preferably has a large channel cross section throughout its configuration. 这尤其应用于下面的情况,使进气孔和出气孔的管道横截面形成为使在吸气过程中口腔中的负分压不超过300Pa。 This is particularly applied to the following case, the air intake pipe cross-section and a hole is formed such that the oral cavity during inhalation negative partial pressure does not exceed 300Pa.

[0017] 作为挥发酸,优选使用醋酸;也可以使用其它酸,如果它们在室温(约15〜25°C) 下是可挥发的或在热(高达约100°c)影响下可以转变成气相(例如乳酸、苹果酸、丙酸)。 [0017] As volatile acid, preferably acetic acid is used; other acids may also be used, if they are volatile at room temperature (about 15~25 ° C) or hot (up to about 100 ° c) may be converted into the gas phase under the influence (e.g. lactic acid, malic acid, propionic acid). 也可以使用不同酸的组合。 It may also be used in combination of different acids. 醋酸由于其高挥发性,以较低的浓度和较大的总量使用,也可以与添加剂结合使用。 Acetic acid due to its high volatility, and in lower concentrations greater amount, can also be used in combination with additives. 挥发性、可吸入碱性活性物质尤其是指在上述温度下挥发性的、或可以转变成气相的物质。 Volatile, inhalable basic active substance and particularly to volatile at the above temperature, or can be converted into gas substances.

[0018] 此外,根据具体的实施方案,含有活性物质的制剂另外包含至少一种适于吸入的溶剂(优选乙醇)或/和至少一种挥发性辅助物质(优选薄荷醇)。 [0018] Further, according to a specific embodiment, the formulation containing the active substance suitable for inhalation further comprises at least one solvent (preferably ethanol) and / or at least one volatile auxiliary substance (preferably menthol). 含有酸的制剂可以同样包含至少一种这种溶剂或/和至少一种挥发性辅助物质。 Acid-containing formulations may also contain at least one such solvent and / or at least one volatile auxiliary substance. 适当的挥发性辅助物质尤其是使人感到愉快的香料和调味剂(如柠檬油精、桉油精、薄荷油、樟脑或萜类的其它物质;包括前述物质的结合)。 Suitable volatile auxiliary substances, especially people feel (other species such as limonene, eucalyptol, peppermint oil, camphor or terpenes; including binding foregoing) pleasant fragrance and flavoring agents.

[0019] 本发明进一步包括上述装置的制造方法。 [0019] The present invention further comprises a method for manufacturing the device. 这些方法通常包括以下步骤: These methods generally comprise the steps of:

[0020] 通过深拉法或其它本领域中公知的加工方法(如注塑法)制造成形部件,所述的成形部件包括接收所述第一制剂的第一长形凹部,及接收所述第二制剂的第二长形凹部; [0020] molded member manufactured by deep-drawing or other well-known in the art processing methods (e.g., injection molding), the molding member comprises a first elongated recess receiving said first formulation and said second receiving the second elongated concave portion of the formulation;

[0021] 将预定量的含有尼古丁碱或另一碱性活性物质的第一制剂放入所述的第一凹槽中; [0021] A predetermined amount of the first formulation comprises nicotine base, or another basic active substance into said first recess in;

[0022] 将预定量的含有酸的第二制剂放入所述的第二凹槽中。 [0022] A second formulation containing a predetermined quantity of acid into said second recess.

[0023] 根据本发明的装置通过使用由深拉法制造的成形部件可以简单的方式及低成本制造。 [0023] can be manufactured in a simple manner and at low cost by using the molding member manufactured by the deep drawing apparatus according to the invention. 适合于该目的的优选材料为具有碱性物质,尤其是尼古丁不渗透的涂层的聚酯材料。 Suitable for this purpose is preferably a material having alkaline substance, in particular a polyester material nicotine impermeable coating. 首要适于此目的的为丙烯腈和甲基丙烯酸酯(Barex® ;英国)的共聚物。 Copolymers; acrylonitrile and methacrylate (UK Barex®) adapted to the primary purpose for this. 优选使用聚对 It preferred to use poly

苯二甲酸乙二醇酯-Barex层压板。 -Barex terephthalate laminate.

[0024] 通过深拉法的手段,在形成两个进气道的成形部件内提供了凹部。 [0024] by means of deep-drawing, it is provided in the recess forming member formed of two port. 此外,可以提供与所述的两个凹部连接且形成出气道的另外的凹部。 Further, two recesses may be provided connecting the outlet channels and forming a further recess. 进气道和出气道具有基本上圆柱形的结构,但是它们也可以具有不同的几何形状。 Inlet and outlet channels having a substantially cylindrical configuration, but they may also have different geometries.

[0025] 具有凹部的成形部件形成装置的底部;上部可以通过具有相应地提供的凹槽的第二成形部件,或通过作为盖的平面膜或层形成。 [0025] The bottom of the device shaped member having a concave portion is formed; may be an upper, or formed by a second member having a recess shaped correspondingly provided by the flat film or as a cap layer. 放入制剂后,上部和底部以已知的方式(如胶接、焊接)彼此连接。 After formulation into the upper and bottom in a known manner (e.g. glued, welded) to each other.

[0026] 可以通过提供另外的突起(其同样可以用深拉法制造)使在成形部件中形成进气道的凹部或成形部件安置,以使各挥发性组分的汽化速率可以在几何学上被限制。 [0026] The concave portion may be shaped member or disposed in the intake passage forming member is formed by providing additional projections (which also can be manufactured by deep drawing), so that the vaporization rate of the volatile component may be in various geometrically Is limited. 此方法另外还可以实现优选以等摩尔量递送活性物质碱和酸。 This method of addition may also be implemented preferably in an equimolar amount to deliver the active substance base and an acid.

[0027] 该装置至少部分地,但优选完全地由对于活性物质不渗透的材料,尤其由具有上述涂层的聚酯材料,和/或由金属箔,或这些材料的组合制造。 [0027] This means at least partially, but preferably completely made of material impermeable to the active material, in particular of a polyester material having the above-described coating, and / or a metal foil, or a combination of these materials manufactured.

[0028] 适于作为制备上述制剂的基质原则上为可以用于制备接收尼古丁碱或其它活性物质碱或所述的挥发酸的贮库的任何材料,并且所制得的贮库在吸入条件下,通过汽化向周围空气中释放这些物质。 Any material may be used as the nicotine base or bases other active substance reservoir of the volatile acid or the preparation of the reception, and the depot prepared in [0028] the substrate is adapted for preparing the above formulation principles suction conditions , the release of these substances to the ambient air by evaporation. 适于此目的的材料对于本领域的技术人员是已知的。 Materials suitable for this purpose to those skilled in the art are known.

[0029] 适当的材料为,例如,用于制备经粘膜治疗系统的活性物质贮库的聚合物材料。 [0029] Suitable materials are, for example, a polymer material for the preparation of an active substance reservoir transmucosal therapeutic system. 在该过程中,活性物质(或酸)溶于或分散于聚合的基质中(例如聚丙烯酸酯),任选地加有辅助物质,并将得到的浆状体涂覆到惰性支撑物上并使其干燥。 In this process, the active substance (or acid) is dissolved or dispersed in a polymeric matrix (e.g., polyacrylate), optionally auxiliary substances added, and the resulting mass was coated onto an inert support and dried. 从干燥的含有活性物质的层分割具有已知含量的活性物质或酸的一定表面积及层厚度的片。 Divided piece having a known content of active substance or a certain surface area and the thickness of the acid from the dried layer containing the active substance. 如上所述,可以将这些片作为上述制剂插入到根据本发明的装置中。 As described above, these sheets may be inserted into the device according to the present invention, as the formulation. 装入装置的气流空间中的片状制剂的适当层厚度和表面积由药剂学实践得到。 Suitable thickness and surface area of ​​the sheet-like gas flow space of the formulation is loaded into the device from the obtained pharmaceutical practice.

[0030] 插入到根据本发明的装置中的尼古丁制剂一般具有10%重量的含量,且剂量一般为500mg。 [0030] inserted into the general content of 10% by weight having a nicotine preparation apparatus according to the present invention, and the dose is typically 500mg. 用于各个情况的浓度和剂量可以偏离这些实施例值;尤其是,活性物质含量可以为1〜80%重量,且剂量为10〜lOOOmg。 Concentrations and dosages for each case may be offset from Example values; in particular, the active substance content may be 1~80% by weight, and the dose of 10~lOOOmg.

[0031] 适合作为聚合物基质的,尤其是选自包括聚乙烯、聚丙烯、硅酮聚合物(silicone polymers)(聚二甲基硅氧烷)和聚(甲基)丙烯酸酯的组的聚合物。 [0031] are suitable as the polymer matrix, particularly selected from the group comprising polymeric polyethylene, polypropylene, silicone polymers (silicone polymers) (polydimethylsiloxane) and poly (meth) acrylate groups thereof.

[0032] 而且,可以通过使用热塑性聚合物制备上述的制剂,热塑性聚合物被热液化,且成分(碱性活性物质和/或酸)被定量加入热聚物中。 [0032] Further, the above formulations can be prepared by using a thermoplastic polymer, the thermoplastic polymer is thermally liquefied and the component (basic active substance and / or acid) is quantitatively added to the hot-polymers. 仍为液体的制剂被直接涂覆到深拉吸入装置用于此目的的位置处,并使其固化。 Still liquid formulation is applied directly to the suction means at a location deep-drawn for this purpose, and cured.

[0033] 根据本发明的另一变体,硅酮聚合物(聚二甲基硅氧烷)和交联剂(例如含钼交联剂)用作基质。 [0033] According to another variant as matrix of the present invention, the silicone polymer (polydimethylsiloxane) and a crosslinking agent (e.g., a molybdenum-containing crosslinking agent). 在冷环境下,将尼古丁碱或挥发酸组分以液体形式定量加入到上述混合物中。 In a cold environment, the volatile nicotine base or acid component in liquid form to the mixture was added quantitatively. 将预定量的此混合物涂覆于用于此目的的各个部位。 The mixture was coated in a predetermined amount for each of the parts for this purpose. 封闭该装置后,在加热下后处理,从而制造了活性物质释放制剂的三维结构。 After closing the device, after heating under treatment, thereby producing a three-dimensional structure of the active substance release formulation.

[0034] 含有活性物质或含有酸的制剂优选在各自的进气道的进气口邻近处使用。 [0034] or an acid containing an active substance in the preparation is preferably adjacent the respective intake port of the intake port.

[0035] 如上所述,用于封闭装置的材料优选为如上述的对挥发性成分不渗透的材料。 [0035] As described above, the material for the closure device is preferably a volatile component as the above-impermeable material.

[0036] 在另一优选实施方案中,制造完吸入装置后,用对碱性物质不渗透的可剥离保护层覆盖。 [0036] In another preferred embodiment, the inhalation device is covered with a peelable protective layer impermeable to the basic substance manufacturing finished. 此保护层将只在临近使用前由使用者自己除掉。 This protective layer will only be removed by the user himself just before use. 通过已使用的保护层,形成了含有碱性活性物质的室及含有酸的室,这两个室以基本气密的方式彼此分开且与周围的空气隔绝。 Through the protective layer has been used to form a chamber and the chamber containing an acid containing a basic active substance, the two chambers in a substantially gas-tight manner separated from each other and isolated from the ambient air. 如此,防止了组分的提前反应和老化。 So, to prevent the advance reaction and aging components. 只有去除保护层后,两个室之间的气体交换才可以再发生。 Only after removing the protective layer, the gas exchange between the two chambers can happen again.

[0037] 如必要的话,进气和出气孔也用保护膜覆盖。 [0037] If necessary, the inlet and outlet holes are also covered with a protective film.

[0038] 该装置可有利地用于戒烟,或在必要的情况下,也可以用于对尼古丁渴望的无烟的满足。 [0038] The device may advantageously be used for smoking cessation, or if necessary, may also be used to meet the smokeless nicotine craving.

具体实施方式 Detailed ways

[0039] 将通过实施例和附图的图示说明本发明。 [0039] The present invention will be illustrated by the embodiments and the accompanying drawings illustrating embodiments. 除非另外指明,附图标记的含义在所有附图中是相同的。 Unless otherwise indicated, the meaning is the same reference numerals in all figures.

[0040] 图IA显示根据本发明的装置(1)的市售形状(剖视图)。 [0040] FIG IA display apparatus according to the shape of commercially available (1) of the present invention (sectional view). 该装置由外壁(2)形成;它具有两个气流道(a,b),大约在该气流道的中间,其扩大形成各自的一个室(3a,3b), 且此后合并形成出气道(7)。 The device is formed by the outer wall (2); it having two flow channel (a, b), approximately in the middle of the runner, which form a respective one expansion chamber (3a, 3b), and thereafter combine to form outlet channels (7 ). 在室(3a,3b)中,分别具有含尼古丁制剂(5)和含酸制剂(4)。 Chamber (3a, 3b) are, respectively, having a nicotine-containing formulation (5) and acid-containing formulation (4).

[0041] 图IA显示该装置使用前的状态。 [0041] FIG IA show a state before use of the device. 气流道(a,b)的进气孔和出气孔还是关闭的,且室(3a,3b)被膜(13)彼此分开,因此两个组分(4,5)的混合还不能发生。 Air intake flow channel (a, b) and the vent or closed, and the chamber (3a, 3b) film (13) separated from each other, and therefore mixing of the two components (4,5) can not occur.

[0042] 图IB显示图A中显示的装置在打开膜(13)(如通过热或通过挤过)和进气与出气孔(A,B,C)后的操作状态(同样为纵剖面图)。 [0042] FIG IB in the opened film (13) (e.g., by heat or by a squeeze through) and the intake operation state after the hole (A, B, C) is likewise a longitudinal sectional view (FIG. A display device in ). 进气和出气孔可以例如通过沿着装置中提供的穿孔(图IA中的11、12)破开或撕下被打开(图IB中未显示层(8))。 Inlet and outlet holes may be, for example, through perforations (11, 12 in FIG. IA) provided along a break or tear off device is opened (not shown in FIG. IB layer (8)).

[0043] 吸气时,空气一方面流经进气孔(A)和进气道(a),另一方面流经进气孔(B)和进气道(b)。 [0043] When the intake air flows through the inlet opening on the one hand (A) and inlet (A), on the other hand flows through the inlet opening (B) and the inlet (b). 虚线箭头表示吸入过程中空气的流动方向。 Dashed arrows indicate the direction of flow during the suction of air. 两个进气道(a,b)合并形成具有出气孔(C)的出气道(7)。 Two inlet (a, b) combine to form outlet channels (7) having a hole (C) of. 在进气道(a)的区域具有正好在进气孔(A)之后的含尼古丁制剂(5),且在进气道(b)的区域具有正好在进气孔(B)之后的含酸制剂(4)。 Just after an acid having exactly the inlet hole (B) in the nicotine-containing formulation after the inlet opening (A) (5), and having inlet regions (b) in the region of the inlet (a), formulation (4). 当空气流过时,尼古丁从制剂(5)挥发进气道(a)中,而包含于制剂(4)中的酸性化合物蒸发气道(b)中。 When the air flows, from the nicotine formulation (5) Volatile port (a), while the acidic compound contained in the formulation was evaporated airways (b) (4) in the. 在出气道⑵的区域,碱和酸的蒸气混合,且得到了近似中性至微酸性条件。 ⑵ in the region of the outlet channel, the mixing base and acid vapor, and the resulting approximate neutral to slightly acidic conditions. 通过出气孔(C), 优选经由口腔吸入形成的包括环境空气与其中所包含的尼古丁盐的气雾剂。 By vent (C), preferably via oral inhalation aerosol comprising nicotine salts and ambient air contained therein is formed. [0044] 图IC显示图IB中示意性表示的吸入装置的X平面处的剖面图。 [0044] FIG IC X plane sectional view showing the inhalation device in FIG. IB schematically represented. 进气道(a,b)通过深拉法预成型,以使它们具有凹的形状。 Inlet (a, b) by deep-drawing the preform, so that they have a concave shape. 在气槽(a,b)的区域,分别具有含活性物质制剂(5)和含酸制剂(4)。 Gas in the region of the groove (a, b) respectively having a formulation containing an active material (5) and acid-containing formulation (4). 用一平的、尼古丁不渗透层(8)覆盖在所述的装置的下面。 With a flat, nicotine impermeable layer (8) underneath the cover of the apparatus.

[0045] 图2A显示根据本发明的吸入装置的另一实施方案的市售形状(纵剖面)。 [0045] Figure 2A shows another embodiment in accordance with the shape of commercially available inhalation device according to the invention (longitudinal section). 进气和出气孔(A,B,C)仍是关闭的。 Inlet and outlet holes (A, B, C) is still closed. 槽(a,b)的中间区域扩大形成各自的室(3a,3b)。 An intermediate region of the groove (a, b) form a respective expansion chamber (3a, 3b). 各制剂(4,5)的室(3a,3b)被并排布置,且在空间上彼此分开,以使制剂的混合还不可能(使用前的状态)。 Each formulation (4,5) of the chamber (3a, 3b) are arranged side by side and separated from each other spatially, so that the mixed formulation also possible (state before use).

[0046] 图2B显示图2A中所表示的吸入装置在平面X处的剖面图。 Cross-sectional view [0046] FIG 2B show an inhalation device in FIG. 2A in the plane indicated at X. 进气道(a,b)和室(3a, 3b)通过深拉法在外壁(2)中形成且为凹入的形状。 Inlet (a, b) and the chamber (3a, 3b) is formed by deep-drawing in of the outer wall (2) and concave in shape. 在室(3a,3b)内分别具有含活性物质制剂(5)和含酸制剂(4)。 Within the chamber (3a, 3b) each having a formulation containing an active material (5) and acid-containing formulation (4). 用一平的、尼古丁不渗透层(8)覆盖所述装置的下面。 With a flat, nicotine underlying layer (8) covering said impermeable means.

[0047] 图2C为图2A和2B中所示的实施方案的另一纵剖面。 [0047] FIG 2C is a longitudinal section of another embodiment shown in FIGS. 2A and 2B. 该装置显示为准备使用的状态。 The apparatus is shown as a state ready for use. 为了使用图2A中所描述的装置,使用前沿着线(14)将其折叠,所述的线可以例如以穿孔或弱线的形式提供,从而通过沿中间折叠在纵向上使两个气流槽(a,b)和室(3a,3b) 位于彼此之上。 In order to use the device described in FIG. 2A, using the leading edge line (14) it is folded, the wire may be provided, for example in the form of perforations or line of weakness, so that by folding the intermediate gas stream along the two grooves in the longitudinal direction ( a, b) and the chamber (3a, 3b) located above one another. 可以分别通过例如沿为此目的提供的穿孔(11,12)破开而打开进气与出气道的孔。 For example, along the perforation holes (11, 12) provided for that purpose to break open the intake opening and outlet channels can be separately. 如此得到了功能性吸入装置。 The thus obtained functional inhalation device. 虚线箭头表示吸入过程中气流的方向。 Dashed arrows indicate the direction of the suction air flow process. 管或接口管(9)可以滑移在两个出气孔(C,C')上,从而形成联合出气道(7')和联合出气孔(D)。 Tube or mouthpiece (9) may slide in the two air outlet (C, C '), thereby forming a joint outlet channel (7') and the joint hole (D).

[0048] 图2D显示图2C所示的操作中的装置在平面X处的剖面图。 [0048] Figure 2D shows a cross-sectional view of the operation shown in FIG. 2C in the plane X of the apparatus. 由深拉法形成的室(3a,3b)、壁(2,2')和层(8,8')位于彼此之上。 Chamber (3a, 3b) formed by deep drawing, the wall (2,2 ') and a layer (8,8') on one another.

[0049] 图2E显示图2C所示的操作中的装置在平面Y处的剖面图。 [0049] FIG. 2C to FIG 2E shows a cross-sectional view of the operation of the apparatus shown in the plane Y at. 虚线箭头表示吸入过程中气流的方向。 Dashed arrows indicate the direction of the suction air flow process. 在吸入过程中,气流(A,B)流经分开的道(a,b),经过位于室(3a,3b)中的制剂(4,5)。 During inhalation, channel (a, b) gas stream (A, B) flowing through the separate chamber located after formulation (4,5) (3a, 3b) of. 得到的蒸气或气雾剂在由管或接口管(9)形成的出气道(7')区域结合, 并经由出气孔(D)离开装置。 The resulting aerosol or vapor outlet channels formed in the areas incorporated by the tube or mouthpiece (9) (7 '), and via the vent (D) exits the device.

[0050] 图3A和3B显示根据本发明的装置的另一实施方案(余辉残留图象显示),其中图3B描绘了圆柱形插入部分(31)可以插入其中的管或接口管(30)。 [0050] Figures 3A and 3B show a further embodiment of the device according to the present invention (perspective representation shown), in which FIG. 3B depicts a cylindrical insertion portion (31) which can be inserted into a tube or mouthpiece (30). 插入部分(31)的内部空间通过沿轴向伸展的分隔壁(32)被分成分别接收活性物质制剂和酸组分(未示出) 的两个室(33,34)。 Insertion portion (31) internal space by the axially extending partition wall (32) is divided into a receive active substance formulation and the acid component of the two chambers (33, 34) (not shown). 该插入部分被圆柱形筒(35)围住(在图3A中其被表示为部分切开)。 The insertion portion is a cylindrical drum (35) surrounded (in FIG. 3A is a partial cut which is represented). 在后部区域,在筒中设置有孔(36);所述的孔起到进气孔的作用。 In the rear region, is provided with a hole (36) in the barrel; bore the hole into play the role. 在后面(38)设置有另一进气孔(37),其关闭了插入部分(31)的后部。 In the back (38) is provided with a further inlet opening (37) that closes the rear insert portion (31). 图3C以平面图显示了该后面。 3C shows a plan view of the back. 孔的数量和布置可以变化。 The number and arrangement of holes may be varied.

[0051] 在制造过程中,将含尼古丁制剂放置于室(33,34)中,例如,将浸有尼古丁的载体材料(如海绵或滤纸),和浸有挥发酸(优选醋酸)的载体材料放置于各自的室中;任选地, 也可以随其加入调味剂或增香剂。 [0051] In the manufacturing process, the nicotine-containing formulation is placed in the chamber (33, 34), for example, nicotine impregnated support material (such as a sponge or filter paper), and impregnated with a volatile acid (preferably acetic acid) support material placed in the respective chamber; optionally, flavoring agents may also be added or flavoring agents therewith. 所有的开口,即前端(V)和孔(36,37)用适当的保护膜或箔关闭。 All openings, i.e., the front end (V) and the bore (36, 37) closed with a suitable protective film or foil.

[0052] 使用前,去除保护膜并将插入部分(31)插入接口管(30)。 [0052] Prior to use, remove the protective film and the inserting portion (31) into the mouthpiece (30). 通过在接口管上抽吸, 空气经由两个后面的孔(36,37)被吸入。 By suction on the mouthpiece, the air via two rear holes (36, 37) is drawn. 该空气流经两个室(33,34)和载体,且同时带走了尼古丁蒸气、酸蒸气以及可选择地加入的增香剂蒸气。 The air flows through the two chambers (33, 34) and a carrier, and simultaneously away nicotine vapor, steam and acid vapor flavoring agent is optionally added. 这些蒸气进入口腔前在接口管的区域中涡流。 These vapors before entering the vortex in the region of the mouth of the mouthpiece. 尼古丁和酸蒸气的混合促进了尼古丁吸入。 Mixed acid vapor and nicotine promotes the nicotine inhaler. 为此,提供给接口管(30)多个突起或齿(39)是有利的。 To this end, a mouthpiece (30) a plurality of projections or teeth (39) is advantageous. 这些突起和齿优选接连地布置在几个偏移列中。 These projections and the teeth preferably are arranged successively in several offset columns. 接口管(30)为两端均开口的基本上圆柱形的套管,其优选短于插入部分(31)。 A substantially cylindrical mouthpiece tube (30) is open at both ends, which is preferably shorter than the insertion portion (31). [0053] 突起或齿(39)也可以形成为螺旋形(helical shape)、S-形或螺线形(spiral) 挡板,从而达到空气更好的涡流以及气体更好的混合。 [0053] The protrusions or teeth (39) may be formed in a spiral shape (helical shape), S- or helical shape (Spiral) baffles, so as to achieve better air swirl and better mixing of gases.

[0054] 图4A显示根据本发明的装置的另一实施方案的透视图。 [0054] FIG 4A shows a perspective view of another embodiment of the device according to the present invention. 该装置包括套管型接口管(30),管(41)可以旋转地附着于该套管型接口管上,或管(41)可以旋转滑移到其上面, 或管(41)可以旋转插入其中(箭头的方向)。 The apparatus includes a mouthpiece-type sleeve (30), the tube (41) rotatably attached to the mouthpiece of the sleeve type, or tube (41) can be rotated to slide thereon, or a tube (41) rotatably inserted wherein (direction of the arrow). 优选地,接口管(40)的末端被形成为一定的形状,以使当管(41)滑移到接口管上时,其可以扣合。 Preferably, when the end of the mouthpiece (40) is formed into a shape, such that when the tube (41) to the tube sliding interface, it may snap. 如图3中描述的,接口管面对嘴的孔具有多个突起(39)。 Hole mouthpiece described in FIG. 3 having a plurality of projections facing the nozzle (39). 接口管(40)的内部空间被两个分隔壁分成四个室。 The inner space of the mouthpiece (40) are two partition walls into four chambers. 接口管在两端均开口。 Mouthpiece are open at both ends. 将要与管(41)连接的开口被部分关闭。 To be connected to the tube (41) of the opening is partially closed. 优选地,至少接口管基本为圆形的横截面的一个扇形被关闭,例如图4B中所示的两个相对的扇形。 Preferably, at least one sector of the mouthpiece substantially circular cross-section is closed, as shown for example in FIG. 4B two opposing sectors.

[0055] 滑移管(41)在两端均开口,且在内部以与接口管相同的方式(通过壁(44,45)的方式)被分隔成四个室。 [0055] The sliding tube (41) open at both ends, and is separated by the same manner as the mouthpiece (through the wall (44, 45) manner) into four chambers in the interior. 含尼古丁制剂和含酸制剂分别位于两个相对的室中。 Acid-containing formulations and preparations containing nicotine are located in two opposite chambers.

[0056] 还提供了接口管和管被分隔成2个或3个、或多于4个内部空间的实施方案。 [0056] Also provided mouthpiece and the tube is divided into two or three, four or more embodiments of the internal space.

[0057] 壁或挡板(44,45)还可以形成为螺旋形、S-形或螺线形,从而达到更强烈的空气涡流,并因此达到更好的气体混合。 [0057] The walls or baffles (44, 45) may also be formed in a spiral shape, S- or spiral shape, so as to achieve a more intense vortex of air, and thus achieve better mixing of the gases.

[0058] 通过在管的第一室中插入含尼古丁载体材料,和在相应的对面的室中插入含酸载体材料制备了含尼古丁管(任选地用增香剂改良)。 [0058] In the first chamber through a tube inserted into the nicotine-containing support material, the nicotine-containing tube and (optionally modified with flavoring agents) Preparation of the acid-containing carrier material is inserted in the respective opposite chamber. 然后所有的开口用适当的膜或箔关闭。 Then all of the openings with a suitable film or foil closing. 此外,可以用另外的活性物质或增香剂填充管的其余的室。 Furthermore, with additional active substance or flavoring agents fill tube remaining chambers.

[0059] 使用时,去除保护膜并将管(41)滑移到接口管(40)上,从而扣合。 [0059] In use, the protective film is removed and the tube (41) slipped onto the mouthpiece (40), thereby engaging. 该管被旋转啮合,以使通过相对于接口管旋转管(见双箭头)时,填充的室可以打开和关闭。 The rotating tube is engaged, so that rotation of the mouthpiece through the pipe (see double arrow) relative to the filling chamber may be opened and closed. 这使消费者可以调节希望吸入的气流。 This can be adjusted so that consumers want to inhale air. 如果必要的话,接口管的开口端,和管的开口端各自可以用可拆卸的帽关闭。 If necessary, the open end of the mouthpiece, and an open end of each tube can be closed by a removable cap.

[0060] 图5显示(横截面)图4中描述的实施方案的一种变化。 [0060] FIG. 5 shows a variation of the embodiment described in 4 (cross-section) in FIG. 接口管(40)和管(41) 的内部空间被分成四个管状室(51、52、53、54) ; (50)分别指接口管和管的圆柱形壁。 The mouthpiece (40) and the tube (41) is divided into four internal space of the tubular chamber (51, 52); (50) refer to the cylindrical wall of the tube and the mouthpiece.

[0061] 在这种情况下,浸有活性物质或酸的载体材料以“药筒”的形式插入管中是有利的。 [0061] In this case, it is advantageous impregnated with the active substance or carrier material is inserted into the tube to an acid form "cartridge" in. 在此情况下,管可以形成具有接口管且与其永久地(但可旋转地)相连的装置,这意味着整个装置是可重复利用的。 In this case, the tube may be formed having a mouthpiece and means permanently connected thereto (but rotatable), which means that the entire device is reusable. 所述的“药筒”可以独立储存,且可以制备以具有不同的尼古丁含量(或以含有不同的活性物质)。 The "cartridge" can be stored separately, and may be prepared to have different nicotine content (or containing different active substances).

[0062] 图6以图示表示根据本发明的装置的另一有利的实施方案。 [0062] FIG. 6 shows a further advantageous embodiment of the device according to the present invention is illustrated. 含活性物质制剂(未示出)位于第一室(61),其形成活性物质蒸气可以积聚在其中的较大的气体空间。 Active substance formulation (not shown) located in the first chamber (61) containing an active material which can accumulate in a large vapor gas space therein. 可与增香剂组合的含酸制剂位于第二室(62)。 It may be located in a second chamber (62) with the acid-containing flavoring agent formulation in combination. 宽箭头表示吸入过程中出现的气流的方向。 Wide arrows indicate the direction of air flow occurring during inhalation. 空气经过进气孔(64,65)被吸入。 After the air intake holes (64, 65) is drawn. 这些孔可以具有阀,以防止组分(活性物质、酸)过早混合或/ 和防止组分漏到外面。 These holes may have a valve to prevent the component (active acid) premature mixing and / or component to prevent leakage to the outside.

[0063] 通过接口管(63)吸入时,空气沿着两个不同的路径流进装置:(i)空气通过侧面的孔(64)流进室(61)中,且在该过程中空气将蒸气压预饱和的气体空间冲进接口管(63) 前面的混合区。 [0063] When the inhalation through the mouthpiece (63), the air flows along two different paths into the apparatus: (i) through the hole in the side of the air (64) flows into the chamber (61), and the air in the process saturated vapor pressure of the pre-burst gas space (63) in front of the mixing zone mouthpiece. (ii)同时,空气通过侧面的孔(65)被吸入第二室(62)中。 (Ii) simultaneously, the air passage holes (65) side is sucked into a second chamber (62). 在该过程中,气体也将辅助物质(酸,可能的调味剂)冲进接口管(63)前面的混合区。 In this process, the gas will auxiliary substances (acids, flavoring agents may be) burst into the mouthpiece (63) in front of the mixing zone. 在该混合区,两个气流彼此混合。 In the mixing zone, the two streams mixed with each other. 在该混合过程中,发生预期的活性物质碱的中和作用。 In this mixing process, the expected effect of the active material and the base occurred.

Claims (28)

  1. 通过吸入的方式给予人或动物体碱性活性物质的吸入装置,其中所述的吸入装置包括:包含尼古丁碱或/和另一碱性活性物质的第一制剂;第二或多个其它制剂,所述第二或多个其它制剂中的至少一个包含至少一种适于吸入的挥发酸;其特征在于,所述的吸入装置具有第一进气孔、第二进气孔和出气孔,以使流进第一进气孔的气流主要流过所述的第一制剂,且流进第二进气孔的气流主要流过所述的第二或其它制剂,这两个气流随后在其路径上合并,并经过所述的出气孔离开该吸入装置;并且还在于,所述包含尼古丁碱或/和另一碱性活性物质的第一制剂具有其中以溶解或分散的形式包含所述尼古丁碱或/和另一碱性活性物质的聚合物基质,和/或所述的包含至少一种适于吸入的挥发酸的第二或多个其它制剂具有其中以溶解或分散的形式包含所述适于吸入 By inhalation, inhalation administration apparatus way human or animal body basic active substance, wherein said suction means comprises: a base comprising nicotine and / or another basic formulation of a first active material; a second or more other agents, said second plurality or at least one other formulation suitable for inhalation comprising at least one volatile acid; wherein said suction means having a first intake port, the second intake and outlet holes, in order to flowing into the first air intake port flows mainly through the first formulation and the second intake port flows into the main gas stream flowing through said second or further formulation, which in its path the two streams subsequently merge, and after leaving the air outlet of the inhalation device; and further comprising, nicotine base and / or another basic first formulation comprises the active substance has dissolved or dispersed form which comprises a nicotine base and / or another basic polymer matrix and the active substance, and / or the second or more other formulation suitable for inhalation comprising at least one volatile acid having dissolved or dispersed form which comprises the aptamer inhalation 的挥发酸的聚合物基质,并且所述第一制剂的聚合物基质和所述的第二或多个其它制剂的聚合物基质都基于选自包括聚乙烯、聚丙烯、硅酮聚合物和聚(甲基)丙烯酸酯的组中的聚合物。 Volatile acid polymer matrix and the polymer matrix of the first formulation and said second formulation or more other polymer matrices are selected based include polyethylene, polypropylene, silicone polymers and (meth) acrylate groups in the polymer.
  2. 2.根据权利要求1所述的吸入装置,其特征在于,所述的第一制剂和第二制剂或多个其它制剂在该吸入装置内分开的位置使用。 2. The inhalation device according to claim 1, wherein said first formulation and second formulation or separate formulations more other in the use position of the inhalation device.
  3. 3.根据权利要求1所述的吸入装置,其特征在于,所述的第一制剂包含与至少一种适于吸入的溶剂结合的尼古丁碱或/和另一碱性活性物质。 3. The inhalation device according to claim 1, wherein said first formulation comprises nicotine base and / or another basic active substance in combination with at least one solvent suitable for inhalation.
  4. 4.根据权利要求1所述的吸入装置,其特征在于,所述的适于吸入的挥发酸与至少一种适于吸入的溶剂结合而被包含于所述的第二制剂或所述的多个其它制剂中。 The plurality of the inhalation device according to claim 1, wherein said volatile acid suitable for inhalation and at least one second solvent formulation suitable for inhalation is contained in the binding or a further formulation.
  5. 5.根据权利要求3或4所述的吸入装置,其特征在于,所述的适于吸入的溶剂为乙醇。 The inhalation device according to claim 3 or claim 4, wherein said solvent is ethanol suitable for inhalation.
  6. 6.根据权利要求1所述的吸入装置,其特征在于,所述的适于吸入的挥发性酸为选自包括醋酸、乳酸、苹果酸和丙酸的组中。 6. The inhalation device according to claim 1, wherein said volatile acid suitable for inhalation selected from the group comprising acetic acid, lactic acid, malic acid, and propionic acid groups.
  7. 7.根据权利要求1所述的吸入装置,其特征在于,在吸入过程中,尼古丁碱和适于吸入的挥发酸以近似等摩尔量分别从所述第一制剂和所述第二制剂或所述多个其它试剂中释放出来。 7. The inhalation device of claim 1 molar amounts respectively from the first formulation and said second formulation or as claimed in claim, characterized in that, during inhalation, nicotine base and volatile acid suitable for inhalation approximately equal to said plurality of other release agents.
  8. 8.根据权利要求1所述的吸入装置,其特征在于,在持续1〜IOs且达到0. 1〜11/ min的吸气速度的一次吸入过程中,所述的吸入装置从所述的第一制剂向吸入的空气中释放5〜250 μ g的尼古丁碱或另一碱性活性物质。 8. The inhalation device according to claim 1, wherein the first suction means and a suction 1~IOs duration reaches 0. 1~11 / min during the intake speed, from the said a release formulations 5~250 μ g to nicotine inhaled air base or another basic active substance.
  9. 9.根据权利要求8所述的吸入装置,其特征在于,所述吸入装置从所述的第一制剂向吸入的空气中释放10〜100 μ g的尼古丁碱或/和另一碱性活性物质。 9. The inhalation device according to claim 8, wherein the release means from 10~100 μ g to the formulation of the first air intake or nicotine base / basic active agent and the other of said suction .
  10. 10.根据权利要求1所述的吸入装置,其特征在于,在吸入过程中,在所述吸入装置的内部空间中形成气溶胶微粒。 10. The inhalation device according to claim 1, characterized in that, during inhalation, the aerosol particles are formed in an inner space of the suction device.
  11. 11.根据权利要求10所述的吸入装置,其特征在于,所述气溶胶微粒的尺寸小于10 μ m。 11. The inhalation device according to claim 10, wherein the size of aerosol particles less than 10 μ m.
  12. 12.根据权利要求1所述的吸入装置,其特征在于,所述的第一制剂和/或所述第二制剂或所述多个其它制剂包含至少一种另外的挥发性的且适于吸入的添加剂。 12. The inhalation device according to claim 1, wherein said first formulation and / or the second formulation or other formulation comprises a plurality of at least one additional volatile and suitable for inhalation additives.
  13. 13.根据权利要求12所述的吸入装置,其特征在于,所述另外的添加剂为薄荷醇。 13. The inhalation device according to claim 12, wherein the additional additive is menthol.
  14. 14.根据权利要求1所述的吸入装置,其特征在于,该吸入装置至少部分地由对于所述碱性活性物质不渗透的材料制造。 14. The inhalation device according to claim 1, wherein the means for partially manufactured from the basic active substance impermeable material, at least the suction.
  15. 15.根据权利要求1所述的吸入装置,其特征在于,该吸入装置完全由对于所述碱性活性物质不渗透的材料制造。 15. The inhalation device according to claim 1, characterized in that the device is made entirely to the basic active substance impermeable material suction.
  16. 16.根据权利要求14或15所述的吸入装置,其特征在于,所述对于所述碱性活性物质不渗透的材料选自:涂覆有丙烯腈和甲基丙烯酸酯共聚物的聚酯材料,和/或金属箔或上述材料的组合。 16. The inhalation device of claim 14 or claim 15, wherein said active substance into the alkaline impermeable material is selected from: acrylonitrile and coated with methacrylate copolymer polyester material , combined, and / or a metal foil or the above materials.
  17. 17.根据权利要求1所述的吸入装置,其特征在于,在该吸入装置制造后及储存中,用对碱性活性物质不渗透的可剥离保护层覆盖,从而由该可剥离保护层形成含有碱性活性物质的室和含有适于吸入的酸的室,这两个室以气密的方式彼此分开且与周围空气隔绝。 17. The inhalation device according to claim 1, wherein the inhalation device after manufacture and storage, covered with a peelable protective layer to the basic active agent impermeable, thereby forming a peelable protective layer contains basic active substance chamber and a suction chamber adapted acids containing two chambers separated from each other in an airtight manner and is isolated from the ambient air.
  18. 18.根据权利要求1所述的吸入装置,其特征在于,进气孔和出气孔的管道横截面形成为使在吸入过程中口腔中的负分压最多为300Pa。 18. The inhalation device according to claim 1, characterized in that the inlet holes and outlet holes of the pipe cross-section is formed such that the oral cavity during inhalation negative partial pressure of at most 300Pa.
  19. 19.根据权利要求1所述的吸入装置,其特征在于,进气孔和出气孔的管道横截面形成为使在吸入过程中口腔中的负分压最多为200Pa。 19. The inhalation device according to claim 1, characterized in that the inlet holes and outlet holes of the pipe cross-section is formed such that the oral cavity during inhalation negative partial pressure of at most 200Pa.
  20. 20.根据权利要求1所述的吸入装置,其特征在于,该吸入装置包括至少一个通过深拉法制造的成形部件,其中具有形成第一进气道和第二进气道、以及通过合并这两个气道形成的出气道的长形凹部。 20. The inhalation device according to claim 1, characterized in that the suction means comprise at least a shaped part produced by deep-drawing, having a first port and a second intake port is formed, and by combining this oblong recess outlet channels formed by two airway.
  21. 21.根据权利要求20所述的吸入装置,其特征在于,该吸入装置具有各通过深拉法形成的上部和底部,这两个成形部件具有所述的长形凹部且以下述的方式彼此连接:通过彼此相对设置的长形凹部,形成了具有第一进气孔的第一进气道和具有第二进气孔的第二进气道,以及通过结合这两个进气道的具有出气孔的出气道。 21. Inhalation device according to claim 20, characterized in that the suction means each having an upper and a bottom formed by deep-drawing, the two elongate recesses of the shaped member and having connected to each other in the following manner : by oblong recess disposed opposite to each other, forming a first port and a second port having a second intake port having a first intake port, and having an intake port by combining the two outlet passageways pores.
  22. 22.根据权利要求20或21所述的吸入装置,其特征在于,所述的第一制剂位于形成第一进气道的长形凹部中,且所述的第二制剂位于形成第二进气道的长形凹部中。 22. The inhalation device of claim 20 or claim 21, wherein said first formulation positioned oblong recess formed in the first intake port, and said second formulation forms a second inlet located elongate channel recess.
  23. 23.制造根据权利要求1〜22中的任一项的吸入装置的方法,该方法包括以下步骤: 制造成形部件,所述成形部件包括接收所述第一制剂的第一长形凹部,及接收所述第二制剂的第二长形凹部;将预定量的含尼古丁碱或另一碱性活性物质的第一制剂放入所述的第一长形凹部中;将预定量的含适于吸入的酸的第二制剂放入所述的第二长形凹部中。 23. A method of manufacturing the inhaler device according to any one of claims 1~22, the method comprising the steps of: manufacturing a shaped member, said shaped member comprises a first elongated recess for receiving the first formulation, and receiving said second elongated recess of the second formulation; a predetermined amount of first formulation containing nicotine base or another basic active substance into the first portion of the elongated recess in; containing a predetermined amount suitable for inhalation the second portion of the second elongated recessed into the formulation of acid.
  24. 24.根据权利要求23所述的方法,其特征在于,填充的成形部件用对碱性活性物质不渗透的可剥离保护层覆盖,从而通过可剥离保护层形成含该碱性活性物质的室及含适于吸入的酸的室,这两个室以气密的方式彼此分开且与周围的空气隔绝。 24. The method according to claim 23, wherein the filling member is formed with a peelable protective layer for basic active substance impermeable cover, thereby forming a chamber containing the basic active substance by a peelable protective layer, and containing an acid suitable for inhalation chamber, the two chambers separated from each other in an airtight manner and is isolated from the ambient air.
  25. 25.根据权利要求23或24所述的方法,其特征在于,在成形部件制造过程中,通过深拉法形成了与所述的第一长形凹部和所述第二长形凹部连接且形成出气道的再一长形凹部。 25. The method of claim 23 or claim 24, wherein, in the manufacturing process forming member is formed by deep-drawing is connected to the first elongated portion and said second recessed elongate recess portion is formed and outlet channels a further elongated recess.
  26. 26.根据权利要求25所述的方法,其特征在于,填充的成形部件与作为上部、且具有与所述填充的成形部件的凹部对应的长形凹部的成形部件连接,从而通过各自的、叠置的凹部形成具有第一进气孔的第一进气道,具有第二进气孔的第二进气道,以及具有出气孔的出气道。 26. A method according to claim 25, wherein the filling member is formed as the upper connection, and having a shaped member with the filling member is shaped elongated recess portion corresponding to the recess, so that by a respective, stacked forming a second recess portion facing a first intake port having a first intake port having a second air intake port, and a vent outlet passageways.
  27. 27.根据权利要求1〜22中的任一项的吸入装置用于戒烟或用于尼古丁渴求的无烟满足的应用。 27. The inhalation device according to any one of 1~22 in an application for quitting smoking or smokeless nicotine to satisfy craving claim. 3 3
  28. 28.根据权利要求1〜22中的任一项的吸入装置用于同时吸入碱性活性物质及一种或多种挥发酸化合物的应用。 28. The inhalation device according to any one of 1~22 basic active agent for simultaneous suction and application of one or more volatile compounds as claimed in claim acid.
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CN1889861A (en) 2007-01-03
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DE10356925B4 (en) 2006-05-11

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