CN1883630A - Oral liquid for treating traumatic injury and method for preparing same - Google Patents

Oral liquid for treating traumatic injury and method for preparing same Download PDF

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Publication number
CN1883630A
CN1883630A CN 200610051843 CN200610051843A CN1883630A CN 1883630 A CN1883630 A CN 1883630A CN 200610051843 CN200610051843 CN 200610051843 CN 200610051843 A CN200610051843 A CN 200610051843A CN 1883630 A CN1883630 A CN 1883630A
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radix
traumatic injury
rhizoma
medicine
oral
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陈坚强
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HANGZHOU ZHUYANGXIN PHARMACEUTICAL CO Ltd
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HANGZHOU ZHUYANGXIN PHARMACEUTICAL CO Ltd
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Abstract

Disclosed is a Chinese oral medicament for treating traumatic injury and process for preparation, wherein the medicament is prepared from Korean monkshood root 88-264, ledebouriella root 7.5-22.5, notopterygium root 7.5-22.5, arisaema tuber 14.5-43.5 and dahurian angelica root 7.5-22.5 through the steps of proportioning, disintegrating, grinding, sieving, mixing and loading into capsules.

Description

Oral medicine of treatment traumatic injury and preparation method thereof
Technical field
The present invention relates to a kind of is the oral medicine and preparation method thereof of the treatment traumatic injury made of raw material with the Chinese herbal medicine.
Background technology
People are at meridians or ligament sprain, muscle swelling, even with wound bleeding, bone splits, fracture etc. when ailing, usually treat with traumatic injury class medicine, wherein in the majority with plaster and medicated wine again, oral medicine is less, though they are reducing swelling and alleviating pain, antiinflammatory, dispelling wind-evil and transforming calculus, active muscles and bones to a certain extent, even also have effect such as synthetism, but also have following problem: 1) curative effect of treatment traumatic injury is not too obvious, and the time of treatment is long, price is also somewhat expensive; 2) using skin allergy appears and ends in the use above-mentioned plaster that cures the wound easily, and also should not use in the hot summer; And the medicated wine that cures the wound also is not suitable for usefulness for the people that can not drink, so their use is restricted; 3) because of with a kind of medicine different people being had different curative effects, old friends wish to increase the kind of medicine, so as to seek to be fit to oneself, the vulnerary of good effect and cheap Chinese herbal medicine, especially treat the oral medicine of traumatic injury.
Summary of the invention
The present invention will overcome existing problem in the above-mentioned prior art, a kind of evident in efficacy, instant effect is provided, and can its simple, contained each Chinese herbal medicine of preparation method science can conveniently be obtained and lower-price characteristic for the oral medicine of directly oral, the cheap treatment traumatic injury of people.
The present invention treats the oral medicine of traumatic injury, and it comprises the Chinese herbal medicine of following weight part ratio: give birth to Radix Aconiti Coreani 88~264, Radix Saposhnikoviae 7.5~22.5, Rhizoma Et Radix Notopterygii 7.5~22.5, Rhizoma Arisaematis 14.5~43.5, the Radix Angelicae Dahuricae 7.5~22.5.
The oral medicine of above-mentioned treatment traumatic injury, optimum weight part ratio of its Chinese herbal medicine is: give birth to Radix Aconiti Coreani 150-200, Radix Saposhnikoviae 10-20, Rhizoma Et Radix Notopterygii 10-20, Radix Angelicae Dahuricae 10-20, Rhizoma Arisaematis 20-40.
The oral medicine of above-mentioned treatment traumatic injury in the weight part ratio of its Chinese herbal medicine, also contains and can make it become the vegetable oil 0.7~2.1 and the Cera Flava 0.014~0.042 of oral soft capsule.
The preparation method of the oral medicine of treatment traumatic injury of the present invention, it is characterized in that: get living Radix Aconiti Coreani 88~264, Radix Saposhnikoviae 7.5~22.5, Rhizoma Et Radix Notopterygii 7.5~22.5, Rhizoma Arisaematis 14.5~43.5, the Radix Angelicae Dahuricae 7.5~22.5, and it is standby that Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Rhizoma Arisaematis, the Radix Angelicae Dahuricae are ground into fine powder together, will give birth to Radix Aconiti Coreani again and be ground into fine powder and above-mentioned fine powder equivalent incremental method facing-up, crossing screen-aperture is 80 purpose sieves, mixing incapsulates then, and every is 0.25 gram.
The preparation method of the oral medicine of above-mentioned treatment traumatic injury, the living Radix Aconiti Coreani 150-200 that is taken, Radix Saposhnikoviae 10-20, Rhizoma Et Radix Notopterygii 10-20, Radix Angelicae Dahuricae 10-20, Rhizoma Arisaematis 20-40.
The preparation method of the oral medicine of above-mentioned treatment traumatic injury, also can in its mixed powder, add Cera Flava oil, it is that 0.7~2.1 vegetable oil and weight part ratio are 0.014~0.042 Cera Flava that this Cera Flava oil comprises weight part ratio, and in stirring while adding, become even suspension, after this preparation of soft capsule method makes the oral soft capsule for the treatment of traumatic injury routinely.
Beneficial effect of the present invention: 1) because of the contained herbal component of oral medicine of the present invention has dispelling wind-evil and transforming calculus, effect such as invigorate blood circulation can be used for the wound redness due to the traumatic injury, hypochondrium pain with internal injury also can be used for the treatment of associated conditions such as lumbar muscle strain, scapulohumeral periarthritis, arthralgia; Have functions of detumescence, relieving inflammation, calmness and analgesic effect by the experiment of mice and rat being gone back susceptible of proof oral medicine of the present invention, and can also reduce the rat temperature heating that causes because of yeast during high dose; Verify that in clinical trial the curative effect of be 91.46% in the curative effect of treatment in the acute soft tissue contusion, treatment being sprained is 88.76%, the curative effect of treatment acute ankle damage is 91.1%, the obvious effective rate of treatment rheumatic Bi syndrome is 95%; Therefore, oral medicine of the present invention can be used as the better and stable treatment drug for traumatic injuries of a kind of curative effect and selects for use for people; 2) oral medicine of the present invention can be with warm yellow wine or warm water delivery service, also can or take out capsule 's content and with Chinese liquor or vinegar external application, to be convenient for people to according to own situation use with the crushing of medicine grain; 3) draw materials convenience, the moderate cost of oral medicine of the present invention are beneficial to sick and wounded patient and cure the disease.
The specific embodiment
The oral medicine of experimental example 1, present embodiment treatment traumatic injury, it comprises the Chinese herbal medicine of following weight part ratio: give birth to Radix Aconiti Coreani 88~264, Radix Saposhnikoviae 7.5~22.5, Rhizoma Et Radix Notopterygii 7.5~22.5, Rhizoma Arisaematis 14.5~43.5, the Radix Angelicae Dahuricae 7.5~22.5.
Above-mentioned Radix Aconiti Coreani is dry daughter root and the parent root of ranunculaceae plant Aconitum carmichjaelii Debx. Aconitum coreanum (Lev1.) Raip, and nature and flavor are hot, and are poisonous, goes into the heart, spleen, kidney channel; Has recuperating depleted YANG and rescuing the patient from collapse, dispelling cold by warming the meridian, analgesic function.
Above-mentioned Rhizoma Arisaematis is the dry tuber of herbaceos perennial Rhizoma Arisaematis Arisaema erubescens (Wall.) Schott., Arisaema heterophyllum B1. Arisaema heterophyllum BL. arisaema amurense Maxim Arisaema amurense Maxim. or Rhizoma pinelliae pedatisectae Pinelliapedaeisecta Schott, nature and flavor hardship, suffering, temperature, poisonous, return liver, spleen channel; Has drying dampness to eliminate phlegm, expelling wind for relieving convulsion, dispersing swelling and dissipating binds pain-relieving functions.
The above-mentioned Radix Angelicae Dahuricae is the dry root of samphire Radix Angelicae Dahuricae Angelica dahurica (Fishch.ex Hoffm.) Benth.ethook.f. or Radix angelicae dahuricae, and nature and flavor suffering, temperature attach to the lung and stomach meridians; Has dispeiling pathogenic wind and removing dampness, the function of reducing swelling and alleviating pain.As usually join Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae with wind-expelling pain-stopping.
Above-mentioned Radix Saposhnikoviae is umbelliferae Saposhnikovia divaricata Saposhnikovia divaricata (Turcz.) Schischk. dry root, nature and flavor suffering, sweet, and temperature is returned bladder, lung, spleen channel; Has expelling pathogenic wind from the body surface, the function of removing dampness to relieve pain.
Above-mentioned Rhizoma Et Radix Notopterygii is dry rhizome and the root of samphire Rhizoma Et Radix Notopterygii Notopterygium incisum TingexH.T.Chang or broad-leaved Rhizoma Et Radix Notopterygii Notopterygium forbesii Boiss., nature and flavor suffering, hardship, and temperature is returned bladder, Liver Channel; Have and induce sweat, cold expelling, wind-damp dispelling, the analgesic function is used for exterior syndrome due to wind-cold, anemofrigid-damp arthralgia, diseases such as arthralgia.
In a word, livings Radix Aconiti Coreani in the oral medicine of present embodiment treatment traumatic injury can all over the body positive, the dispelling cold and dampness of temperature with the warming the interior cold expelling, thereby can be used for cold-evil's invasion, disease due to cold-damp wins partially, and the Radix Saposhnikoviae of expelling wind and cold (containing volatile oil), the Radix Angelicae Dahuricae (containing Radix Angelicae Dahuricae element), Rhizoma Et Radix Notopterygii (containing volatile oil), warming for resolving cold-phlegm class medicine Rhizoma Arisaematis (processed) (the main benzoic acid that contains) are ministerial drug, but wind-damp dispelling, stopping numbness pain, relieving convulsion, the detumescence function of the Radix Angelicae Dahuricae are more so, and Rhizoma Arisaematis (processed) eliminates the phlegm, dampness, antidotal effect.Whole prescription the monarch and his subjects help mutually, and expectorant has the merit of blood stasis dispelling, and the medicine that dispels the wind also has the effect of circulation of qi promoting; But its Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii priming again can make the property of medicine whole body of leading to.So for soft tissue injury, the aseptic inflammation of various tissues such as rheumatism, rheumatoid disease, bone injury, scapulohumeral periarthritis, and all kinds of blood stasis are pain caused all effective in cure.
The preparation method of the oral medicine of present embodiment treatment traumatic injury, get living Radix Aconiti Coreani 88~264, Radix Saposhnikoviae 7.5~22.5, Rhizoma Et Radix Notopterygii 7.5~22.5, Rhizoma Arisaematis 14.5~43.5, the Radix Angelicae Dahuricae 7.5~22.5, and it is standby that Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Rhizoma Arisaematis, the Radix Angelicae Dahuricae are ground into fine powder together, will give birth to Radix Aconiti Coreani again and be ground into fine powder and above-mentioned fine powder equivalent incremental method facing-up, crossing screen-aperture is 80 purpose sieves, mixing incapsulates then, and every is 0.25 gram.
The oral medicine of present embodiment treatment traumatic injury is carried out observation of curative effect by following experiment to mice, rat.
Experiment 1, this experiment comprise two tests, and one is the swelling test of Mice Auricle, and another is the swelling test of rat paw, by the antiinflammatory performance to this two tests susceptible of proof present embodiment.Now be described below respectively:
Test one: get 50 of male mices, be divided into totally five groups of I, II, III, IV, V (every group of each 10 mice) at random, each is organized mice and feeds by the listed dosage filling of table 1, and dosage g/kg is that the body weight (kg) according to mice is irritated the amount (g) of feeding; Wherein the I group is fed normal saline as negative contrast groups, filling, II, III, IV irritate respectively for three groups and feed dosage is the present embodiment oral medicine of 1.50,1.00,0.50 (g/kg), the V group is as positive controls, and what filling was fed is that aspirin, its amount are 0.20ml/10g.Be administered once earlier in preceding 24 hours in experiment, be administered once next day again, and after the administration for the second time 30 minutes, promptly on the left ear of every mice, be coated with dimethylbenzene 30ul, make it cause inflammation; Cause scorching back 1.5h, left and right two ears are put to death and cut to mice, and take off the disk of left and right two ears respectively with the 8mm card punch, precision is weighed then, counts the weight difference of left and right ear again and lists table 1 in as the swelling degree.From table 1, see, though present embodiment medicine group does not reach the level of positive controls, but compare with matched group, the swelling degree is just little than matched group when dosage is 0.50g/kg, the medicine that present embodiment is described has the anti-swollen property of antiinflammatory, and it is that 1.00,1.50 o'clock swelling degree is littler that dosage is increased to, and the anti-swollen property of antiinflammatory is better.Therefore, the Mice Auricle inflammation that causes of the medicine xylol of present embodiment has significant inhibitory effect.
Table 1 this product xylol causes the influence of mice auricle swelling
Group Dosage (g/kg) The swelling degree
Contrast groups I Normal saline 7.7±2.9
Present embodiment medicine group II 1.50 4.1±2.0 **
III 1.00 5.3±1.8 *
IV 0.50 5.4±2.5
Aspirin V 0.25 3.4±2.1 **
Annotate: compare with matched group *P<0.01 *P<0.05
Test two: get the SD rat, be divided into five groups at random, 8 every group, medicine, the negative contrast groups of pressing listed dosage filling hello the present embodiment of table 2 irritated hello equal-volume normal saline, positive contrast groups is irritated hello aspirin.Press the dosed administration of table 2, and test and be administered once earlier in preceding 24 hours, be administered once next day again; Surveyed behind the volume, administration of the right back sufficient sole of the foot of rat 30 minutes with volumetric method earlier before the administration for the second time, in the right back sufficient plantar subcutaneous injection 10% fresh albumen 0.05ml/ of rat only, so that rat causes inflammation, then respectively at cause scorching back 0.5h, 1.5h (hour), 2.5h, 3.5h, 4.5h, 5.5h measure the volume of the right back sufficient sole of the foot of rat, and with sufficient sole of the foot volume ratio before the administration, draw its swelling degree.Cause scorching back pedal swelling volume in the contrast table 2, can see rat paw edema that the present embodiment medicine can reduce to be caused by Ovum Gallus domesticus album, inflammation is had the obvious suppression effect.
Table 2 this product is to the influence of rat paw edema
Group Dosage g/kg Cause scorching front foot sole of the foot volume Cause scorching back pedal swelling volume
0.5h 1.5h 2.5h 3.5h 4.5h 5.5h
Negative contrast groups The equal-volume normal saline 2.108±0.100 0.550±0.141 0.540±0.100 0.435±0.107 0.416±0.081 0.413±0.190 0.385±0.075
Medicine group of the present invention 1.50 2.155±0.112 0.256±0.142 ** 0.239±0.141 ** 0.205±0.115 * 0.189±0.118 * 0.238±0.111 * 0.209±0.085 *
1.00 2.206±0.174 0.318±0.151 * 0.376±0.202 0.290±0.148 0.245±0.099 * 0.211±0.098 * 0.229±0.070
0.50 2.268±0.171 0.378±0.122 ** 0.398±0.133 0.345±0.130 0.340±0.102 * 0.244±0.079 * 0.254±0.097
Positive contrast groups 0.25 2.064±0.158 0.345±0.163 ** 0.296±0.203 ** 0.246±0.170 ** 0.205±0.174 * 0.194±0.167 * 0.245±0.164 *
Annotate: compare with matched group *P<0.01 *P<0.05
The oral medicine that can confirm present embodiment treatment traumatic injury from test two tests of 1 is when the use of high dose, middle dosage and low dosage, all can make the mice auricle swelling that dimethylbenzene causes, the rat paw edema that Ovum Gallus domesticus album causes that the effect that significantly alleviates is arranged, so the oral medicine of present embodiment treatment traumatic injury has antiinflammatory action.
Experiment 2, to the influence of mice autonomic activities
Get male mice, be divided into I, II, four groups of III, IV (every group of each 10 mice) at random, each is organized mice and feeds by the listed dosage filling of table 3, and dosage g/kg is that the body weight (kg) according to mice is irritated the amount (g) of feeding; Wherein the I group is organized as a comparison, irritates to mice and feeds normal saline, and II, III, IV irritate respectively for three groups and feed dosage is the present embodiment medicine of 1.50,1.00,0.50 (g/kg); After this open the power supply of mice autonomic activities analyzer, with reference to the autonomic activities scale of notation, stablize 5min and begin to measure.At this moment mice is put into the animal activity district, press timing key again, and carry out timing setting, again timing key is resetted, the timing clock timing of promptly starting from scratch.Adjust the stored count of starting from scratch of each timer, the movable number of times of continuous record 5min and list table 3 in.See from table 3, irritate to feed the mice of present embodiment medicine, the number of times of its autonomic activities is less than contrast groups, and feeds increasing progressively and obviously reducing of dosage with irritating, but also reduced the time of staying on transfer rod, illustrates that the medicine of present embodiment has sedation.
Table 3 this product is to the influence of mice autonomic activities
Group Dosage (g/kg) Movable number of times
Contrast groups In appearance water 64.5±15.4
Medicine group of the present invention 1.50 51.5±14.0 **
1.00 54.7±13.9 *
0.50 64.0±19.9
Diazepam 0.001 32.9±23.1 **
Annotate: compare with matched group *P<0.01 *P<0.05
Test 3, cause mouse writhing and measure the number of times of turning round body by acetic acid:
Get 60, the mice of body weight 20 ± 2g, be divided into five groups at random, press table 4 dosage gastric infusion, matched group is given the equal-volume normal saline, and positive controls is given aspirin.Test and be administered once earlier in preceding 16 hours, be administered once next day again, gave each Mus lumbar injection 0.6% acetum 0.1ml/10g in 1 hour after the administration for the second time, and each Mus is turned round the body number of times in the immediate record 20 minutes, and calculate the analgesia percentage rate, list table 4 in.
Table 4 this product Dichlorodiphenyl Acetate causes the influence of mouse writhing number of times
Group Dosage (g/kg) Turn round the body number of times (inferior/20min) The analgesia percentage rate
Matched group In appearance water 37.2±13.1
Medicine group of the present invention 0.50 30.1±10.8 19.09%
1.00 28.1±11.4 * 24.46%
1.50 23.2±10.0 ** 37.63%
Aspirin 0.10 20.6±11.3 ** 44.62%
Annotate: compare with matched group *P<0.01 *P<0.05
When from table 4, seeing the present embodiment oral medicine of using high, medium and low dosage, the blood flow rate of mice is accelerated, be turned round the minimizing of body number of times, and the mice pain threshold raising that hot plate is caused, certain analgesic activity had.
Except from above-mentioned three experiments, proving the oral medicine of present embodiment treatment traumatic injury, have outside functions of detumescence, relieving inflammation effect, sedation and the analgesic activity, when high dose, can also reduce the rat temperature heating that causes because of yeast, that is also have certain antipyretic effect.
In addition, from pharmacodynamics studies show that to the oral medicine of present embodiment treatment traumatic injury, it is except above-mentioned antiinflammatory, analgesic, analgesia, calm, reducing swelling and alleviating pain, effect such as also have dispelling wind-evil and transforming calculus, invigorate blood circulation, thereby be used for the wound redness due to the traumatic injury, hypochondrium pain with internal injury also can be used for the treatment of associated conditions such as lumbar muscle strain, scapulohumeral periarthritis, arthralgia.
The oral medicine of present embodiment treatment traumatic injury can also or be taken out capsule 's content and transfer deposited affected part to get final product with Chinese liquor or vinegar with warm yellow wine or warm water delivery service with the crushing of medicine grain when oral.
The clinical trial of the oral medicine of present embodiment treatment traumatic injury, its curative effect is as follows:
1) curative effect of treatment acute soft tissue contusion in 164 people, clinical recovery 77 people, 73 people have significant curative effect, 14 people effectively, the nonresponder is 0, total obvious effective rate is 91.46%.
2) curative effect of spraining in middle treatment 136 people, clinical recovery 58 people, the person that has the significant curative effect be 60 people, responder be 18 people, invalid be 0; Total obvious effective rate is 88.76%.
3) curative effect of treatment acute ankle damage in 90 people, clinical recovery 11 people, the person that has the significant curative effect be 36 people, responder be 35 people, invalid be 8; Total obvious effective rate is 91.1%.
4) be used for the treatment of rheumatic Bi syndrome, recovery from illness 28%, produce effects 40%, effective 27%, invalid 5%, total obvious effective rate 95%.
The oral medicine of experimental example 2, present embodiment treatment traumatic injury, with optimum weight part ratio of the oral medicine of embodiment 1 and method for making thereof different is its contained Chinese herbal medicine be: give birth to Radix Aconiti Coreani 150-200, Radix Saposhnikoviae 10-20, Rhizoma Et Radix Notopterygii 10-20, Radix Angelicae Dahuricae 10-20, Rhizoma Arisaematis 20-40.
The oral medicine of experimental example 3, present embodiment treatment traumatic injury, in the weight part ratio of the oral medicine of embodiment 1 or 2 and method for making thereof different is its Chinese herbal medicine, also contain and to make it become the vegetable oil 0.7~2.1 and the Cera Flava 0.014~0.042 of oral soft capsule.Its preparation method is: add in mixed powder that to include weight part ratio be that 0.7~2.1 vegetable oil and weight part ratio are 0.014~0.042 Cera Flava oil, and in stirring while adding, become even suspension, after this preparation of soft capsule method makes the oral soft capsule for the treatment of traumatic injury routinely.

Claims (6)

1, a kind of oral medicine for the treatment of traumatic injury, it is characterized in that: it comprises the Chinese herbal medicine of following weight part ratio: give birth to Radix Aconiti Coreani 88~264, Radix Saposhnikoviae 7.5~22.5, Rhizoma Et Radix Notopterygii 7.5~22.5, Rhizoma Arisaematis 14.5~43.5, the Radix Angelicae Dahuricae 7.5~22.5.
2, the oral medicine of treatment traumatic injury according to claim 1 is characterized in that: optimum weight part ratio of said Chinese herbal medicine is: give birth to Radix Aconiti Coreani 150-200, Radix Saposhnikoviae 10-20, Rhizoma Et Radix Notopterygii 10-20, Radix Angelicae Dahuricae 10-20, Rhizoma Arisaematis 20-40.
3, the oral medicine of treatment traumatic injury according to claim 1 is characterized in that: in the weight part ratio of said Chinese herbal medicine, also contain and can make it become the vegetable oil 0.7~2.1 and the Cera Flava 0.014~0.042 of oral soft capsule.
4, the preparation method of the oral medicine of the treatment traumatic injury of the weight part ratio of the described Chinese herbal medicine of a kind of usefulness claim 1, it is characterized in that: get living Radix Aconiti Coreani 88~264, Radix Saposhnikoviae 7.5~22.5, Rhizoma Et Radix Notopterygii 7.5~22.5, Rhizoma Arisaematis 14.5~43.5, the Radix Angelicae Dahuricae 7.5~22.5, and it is standby that Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Rhizoma Arisaematis, the Radix Angelicae Dahuricae are ground into fine powder together, Radix Aconiti Coreani be will give birth to again and fine powder and above-mentioned fine powder equivalent incremental method facing-up will be ground into, crossing screen-aperture is 80 purpose sieves, mixing incapsulates then, and every is 0.25 gram.
5, the preparation method of the oral medicine of treatment traumatic injury according to claim 4 is characterized in that: the living Radix Aconiti Coreani 150-200 that is taken, Radix Saposhnikoviae 10-20, Rhizoma Et Radix Notopterygii 10-20, Radix Angelicae Dahuricae 10-20, Rhizoma Arisaematis 20-40.
6, according to the preparation method of the oral medicine of claim 4 or 5 described treatment traumatic injury, it is characterized in that: add Cera Flava oil in the said mixed powder, it is that 0.7~2.1 vegetable oil and weight part ratio are 0.014~0.042 Cera Flava that this Cera Flava oil comprises weight part ratio, and in stirring while adding, become even suspension, after this preparation of soft capsule method makes the oral soft capsule for the treatment of traumatic injury routinely.
CN 200610051843 2006-06-07 2006-06-07 Oral liquid for treating traumatic injury and method for preparing same Pending CN1883630A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103211937A (en) * 2013-05-21 2013-07-24 杭州朱养心药业有限公司 Vulnerary capsule and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103211937A (en) * 2013-05-21 2013-07-24 杭州朱养心药业有限公司 Vulnerary capsule and preparation method thereof
CN103211937B (en) * 2013-05-21 2014-08-13 杭州朱养心药业有限公司 Vulnerary capsule and preparation method thereof

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