CN103211937B - Vulnerary capsule and preparation method thereof - Google Patents
Vulnerary capsule and preparation method thereof Download PDFInfo
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- CN103211937B CN103211937B CN201310191044.2A CN201310191044A CN103211937B CN 103211937 B CN103211937 B CN 103211937B CN 201310191044 A CN201310191044 A CN 201310191044A CN 103211937 B CN103211937 B CN 103211937B
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Abstract
The invention relates to a vulnerary capsule and a preparation method thereof. The vulnerary capsule specially comprises the following medicinal materials in parts by weight: 176 parts of Korean aconite roof, 15-45 parts of Rhizoma arisaematis, 5-25 parts of angelica root, 5-25 parts of divaricate saposhnikovia root and 5-25 parts of notopterygium root. The vulnerary capsule has excellent pharmaceutical property.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of wound curative capsule and preparation method thereof.
Background technology
Traumatic injury is orthopaedics commonly encountered diseases, and in the process of traumatic injury, inflammatory mediator and cytokine play an important role in inflammatory reaction and tissue repair.Traumatic injury main manifestations is degeneration, inflammatory exudation and the hypertrophy of local organization, has a large amount of cytokines or inflammatory mediator to participate in, as CCL5, IL-1 β, TNF-α, IL-3 etc. in this process.CCL5 plays a part the earliest in inflammatory reaction, and it attracts leukocytic Chemotaxis and activates these cells, and IL-3 is produced by T lymphocyte in vivo, and the antagonist of IL-3 may contribute to the treatment to diseases associated with inflammation, and its clinical practice is still underway.TNF-α is generally considered to judge the important cytokine of inflammatory arthritis pathology process, is conventionally secreted by mononuclear cell, macrophage.TNF-α plays an important role in the cascade reaction of front inflammatory cytokine, and it can regulate the secretion of other front inflammatory cytokines.IL-1 β is called as endogenous pyrogen, except causing fever, also in inflammatory reaction, plays a significant role, and is the inflammatory mediator early occurring in inflammatory reaction.
For traumatic injury clinical commonly used drug be non-steroidal drug as aspirin, indomethacin etc., clinical research shows that this quasi-tradition nonsteroidal antiinflammatory drug of long-term taking produces multiple untoward reaction.To traumatic injury, treatment has accumulated rich experience to Chinese medicine, application wound curative capsule (the accurate word Z10920013 of traditional Chinese medicines for many years clinically, Hangzhou Zhuyangxin Pharmaceutical Co., Ltd produces) be that the ancient prescription dosage changing form that " cures the wound loose " forms, there is effect of dispelling wind-evil and transforming calculus, reducing swelling and alleviating pain, red and swollen for wound outside due to traumatic injury, hypochondrium pain with internal injury etc., get with wind-expelling pain-stopping, eleminating phlegm and freeing channels medicine, form with Radix Aconiti Coreani, Rhizoma Arisaematis, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii prescription, wherein Radix Aconiti Coreani is monarch drug, has effect of dispelling pathogenic wind and eliminating phlegm, dampness pain relieving; Rhizoma Arisaematis drying dampness to eliminate phlegm, relieving spasm to stop pain, mass dissipating and swelling eliminating; Radix Angelicae Dahuricae expelling wind and removing dampness, understand things pain-stopping, the pus swollen-removing that disappears, be all ministerial drug with Rhizoma Arisaematis; Radix Saposhnikoviae inducing diaphoresis to dispel wind, removing dampness to relieve pain, spasmolytic; Rhizoma Et Radix Notopterygii fall apart exterior cold, wind-damp dispelling, sharp joint, this two taste is all adjuvant.All medicines share, and play altogether dispelling wind-evil and transforming calculus, the effect of reducing swelling and alleviating pain.The function of wound curative capsule with cure mainly as dispelling wind-evil and transforming calculus, reducing swelling and alleviating pain, red and swollen for wound outside due to traumatic injury, hypochondrium pain with internal injury etc.; It is generally used for clinically: traumatic injury, various soft tissue injury, strain, skin injury, internal injury; Rheumatic arthritis; The various aseptic inflammations of organizing such as scapulohumeral periarthritis, chondritis, synovitis, tenosynovitis; The pain that the degeneration of joint such as hyperosteogeny, cervical spondylotic radiculopathy causes; Lumbago and skelalgia, sciatica, arthralgia, cervical vertebra pain etc.
Prior art discloses the preparation method of many wound curative capsules.For example, CN1883630A (Chinese Patent Application No. 200610051843.X, Zhu Yangxin) a kind of preparation method of oral medicine for the treatment of traumatic injury is disclosed, get raw Radix Aconiti Coreani 88～264, Radix Saposhnikoviae 7.5～22.5, Rhizoma Et Radix Notopterygii 7.5～22.5, Rhizoma Arisaematis 14.5～43.5, the Radix Angelicae Dahuricae 7.5～22.5, and by Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Rhizoma Arisaematis, it is for subsequent use that the Radix Angelicae Dahuricae is ground into fine powder together, again life Radix Aconiti Coreani is ground into fine powder and above-mentioned fine powder equivalent incremental method facing-up, crossing screen-aperture is 80 object sieves, then mix, incapsulate, every is 0.25 gram (referring to this description of the invention, the 2/5th page of 7-4 reciprocal is capable).
In addition, CN101785818A (Chinese Patent Application No. 201010138372.2, Zhu Yangxin) a kind of preparation method of wound curative capsule is disclosed, be specially: the prescription medical material five tastes, according to Radix Aconiti Coreani 176g, Rhizoma Arisaematis (processed) 29g, Radix Angelicae Dahuricae 15g, Radix Saposhnikoviae 15g, the ratio of Rhizoma Et Radix Notopterygii 15g, except raw Radix Aconiti Coreani, four tastes such as all the other Radix Saposhnikoviaes are ground into fine powder, life Radix Aconiti Coreani is ground into fine powder and above-mentioned fine powder equivalent incremental method facing-up, sieves, mix, incapsulate, make 1000, irradiation sterilization, obtains (referring to this description of the invention [0029] section).
As everyone knows, it is to produce so that certain component relationship is comprehensive by numerous active component that Chinese medicine is brought into play its drug effect, and for example in wound curative capsule, each crude drug has specific quantity relative ratio relationship, is having under the therapeutic effect of clinical verification, these quantity relative ratio relationships should not have large variation, for example, in preparation process.
Therefore, those skilled in the art expect to have a kind of new treatment traumatic injury, various soft tissue injury, strain, skin injury, internal injury; Rheumatic arthritis; The various aseptic inflammations of organizing such as scapulohumeral periarthritis, chondritis, synovitis, tenosynovitis; The pain that the degeneration of joint such as hyperosteogeny, cervical spondylotic radiculopathy causes; The method of the clinical diseases such as lumbago and skelalgia, sciatica, arthralgia, cervical vertebra pain or disease.The effect that provides one to have dispelling wind-evil and transforming calculus, reducing swelling and alleviating pain is particularly provided, can be used for due to traumatic injury outside wound red and swollen, the wound curative capsules such as hypochondrium pain with internal injury.More especially expect to provide a kind of wound curative capsule with good pharmaceutical properties.
Summary of the invention
The object of the present invention is to provide a kind of new treatment traumatic injury, various soft tissue injury, strain, skin injury, internal injury; Rheumatic arthritis; The various aseptic inflammations of organizing such as scapulohumeral periarthritis, chondritis, synovitis, tenosynovitis; The pain that the degeneration of joint such as hyperosteogeny, cervical spondylotic radiculopathy causes; The method of the clinical diseases such as lumbago and skelalgia, sciatica, arthralgia, cervical vertebra pain or disease.The effect that particularly provides one to there is dispelling wind-evil and transforming calculus, reducing swelling and alleviating pain, can be used for due to traumatic injury outside wound red and swollen, the wound curative capsules such as hypochondrium pain with internal injury.A kind of wound curative capsule with good pharmaceutical properties is more especially provided.Have been surprisingly found that, the wound curative capsule that uses the inventive method to obtain has beat all Good Pharmacy character.
For this reason, first aspect present invention provides a kind of wound curative capsule, and its medical material by following weight proportion is made:
Radix Aconiti Coreani 176 weight portions,
Rhizoma Arisaematis 15～45 weight portions,
The Radix Angelicae Dahuricae 5～25 weight portions,
Radix Saposhnikoviae 5～25 weight portions,
Rhizoma Et Radix Notopterygii 5～25 weight portions.
According to the wound curative capsule described in the arbitrary embodiment of first aspect present invention, its medical material by following weight proportion is made:
Radix Aconiti Coreani 176 weight portions,
Rhizoma Arisaematis 20～40 weight portions,
The Radix Angelicae Dahuricae 10～20 weight portions,
Radix Saposhnikoviae 10～20 weight portions,
Rhizoma Et Radix Notopterygii 10～20 weight portions.
According to the wound curative capsule described in the arbitrary embodiment of first aspect present invention, its medical material by following weight proportion is made:
Radix Aconiti Coreani 176 weight portions,
Rhizoma Arisaematis 25～35 weight portions,
The Radix Angelicae Dahuricae 12～18 weight portions,
Radix Saposhnikoviae 12～18 weight portions,
Rhizoma Et Radix Notopterygii 12～18 weight portions.
According to the wound curative capsule described in the arbitrary embodiment of first aspect present invention, its medical material by following weight proportion is made:
Radix Aconiti Coreani approximately 176 weight portions,
Rhizoma Arisaematis approximately 30 weight portions,
The Radix Angelicae Dahuricae approximately 15 weight portions,
Radix Saposhnikoviae approximately 15 weight portions,
Rhizoma Et Radix Notopterygii approximately 15 weight portions.
According to the wound curative capsule described in the arbitrary embodiment of first aspect present invention, its medical material by following weight proportion is made:
Radix Aconiti Coreani approximately 176 weight portions,
Rhizoma Arisaematis approximately 29 weight portions,
The Radix Angelicae Dahuricae approximately 15 weight portions,
Radix Saposhnikoviae approximately 15 weight portions,
Rhizoma Et Radix Notopterygii approximately 15 weight portions.
According to the wound curative capsule described in the arbitrary embodiment of first aspect present invention, its medical material by following weight proportion is made:
Radix Aconiti Coreani approximately 176 weight portions,
Rhizoma Arisaematis approximately 31 weight portions,
The Radix Angelicae Dahuricae approximately 17 weight portions,
Radix Saposhnikoviae approximately 13 weight portions,
Rhizoma Et Radix Notopterygii approximately 15 weight portions.
According to the wound curative capsule described in the arbitrary embodiment of first aspect present invention, its medical material by following weight proportion is made:
Radix Aconiti Coreani approximately 176 weight portions,
Rhizoma Arisaematis approximately 29 weight portions,
The Radix Angelicae Dahuricae approximately 16 weight portions,
Radix Saposhnikoviae approximately 15 weight portions,
Rhizoma Et Radix Notopterygii approximately 14 weight portions.
According to the wound curative capsule described in the arbitrary embodiment of first aspect present invention, wherein said raw Radix Aconiti Coreani is directly pulverized gained powder with it and is added in described wound curative capsule.
According to the wound curative capsule described in the arbitrary embodiment of first aspect present invention, wherein said Rhizoma Arisaematis is Rhizoma Arisaematis (processed).Rhizoma Arisaematis (processed) is known in the art, and it is for example recorded in one 54 pages of Chinese Pharmacopoeia versions in 2010.
According to the wound curative capsule described in the arbitrary embodiment of first aspect present invention, wherein said Rhizoma Arisaematis (processed) is directly pulverized gained powder with it and is added in described wound curative capsule.
According to the wound curative capsule described in the arbitrary embodiment of first aspect present invention, the wherein said Radix Angelicae Dahuricae is directly pulverized gained powder with it and is added in described wound curative capsule.
According to the wound curative capsule described in the arbitrary embodiment of first aspect present invention, wherein said Radix Saposhnikoviae is directly pulverized gained powder with it and adds in described wound curative capsule.
According to the wound curative capsule described in the arbitrary embodiment of first aspect present invention, wherein said Rhizoma Et Radix Notopterygii is directly pulverized gained powder with it and adds in described wound curative capsule.
According to the wound curative capsule described in the arbitrary embodiment of first aspect present invention, wherein said Radix Aconiti Coreani is raw Radix Aconiti Coreani.
According to the wound curative capsule described in the arbitrary embodiment of first aspect present invention, wherein can also comprise the acceptable adjuvant of pharmacy.The selection of pharmaceutic adjuvant and addition are that those skilled in the art rule of thumb prepare demand with capsule and easily determine.Schematically pharmaceutic adjuvant has diluent or filler, binding agent, lubricants/glidants, flavoring agent etc.Diluent or filler are mainly used in adjusting the weight or volume of medicament, to make active component can be prepared into the pharmaceutical preparation of suitable clinical use; Typical diluent or such as such as sucrose, glucose, lactose etc. of saccharide of filler, starch and derivant thereof be corn starch, modified starch, amylum pregelatinisatum, dextrin etc. such as, such as microcrystalline Cellulose of cellulose family; Typical binding agent aqueous solution/suspension that such as starch slurry, PVP, HPMC etc. are mixed with, can also make water or aquiferous ethanol as wetting agent to obtain the effect of binding agent; Lubricants/glidants contributes to improve the mobility of granule so that prepared by preparation, and exemplary lubricants/glidants comprises magnesium stearate, Pulvis Talci, silicon dioxide, micropowder silica gel etc.; Flavoring agent can be used for improving medicine mouthfeel, such as aspartame, stevioside etc.
According to the wound curative capsule described in the arbitrary embodiment of first aspect present invention, wherein also comprise Polyethylene Glycol.In one embodiment, described Polyethylene Glycol is that molecular weight is 2000～20000 Polyethylene Glycol.In one embodiment, described Polyethylene Glycol is that molecular weight is 4000～10000 Polyethylene Glycol.In one embodiment, described Polyethylene Glycol is that molecular weight is 4000～8000 Polyethylene Glycol.
According to the wound curative capsule described in the arbitrary embodiment of first aspect present invention, wherein, for Radix Aconiti Coreani 176 weight portions, the amount of described Polyethylene Glycol is 1～20 weight portion, for example 2～15 weight portions, for example 2～10 weight portions, for example 2～8 weight portions.
According to the wound curative capsule described in the arbitrary embodiment of first aspect present invention, it prepares according to following method substantially: get Radix Aconiti Coreani, Rhizoma Arisaematis, the Radix Angelicae Dahuricae, Radix Saposhnikoviae and Rhizoma Et Radix Notopterygii, be ground into respectively fine powder for subsequent use; By abundant each material mixture, incapsulate, to obtain final product.
According to the wound curative capsule described in the arbitrary embodiment of first aspect present invention, it prepares according to following method substantially: get Radix Aconiti Coreani, Rhizoma Arisaematis, the Radix Angelicae Dahuricae, Radix Saposhnikoviae and Rhizoma Et Radix Notopterygii, be ground into respectively fine powder for subsequent use; The Radix Angelicae Dahuricae is fully mixed homogeneously with Polyethylene Glycol; By abundant each material mixture, incapsulate, to obtain final product.Rhizoma Arisaematis, the Radix Angelicae Dahuricae, Radix Saposhnikoviae and the Rhizoma Et Radix Notopterygii amount in formula is lower, its mixing uniformity in formula needs special concern, the inventor has been found that, in rustless steel mixing apparatus, in large batch mixed material after abundant mix homogeneously, the amount of the Radix Angelicae Dahuricae in the inner residual powder of cleaning mixing apparatus that the amount of the Radix Angelicae Dahuricae compares is low, shows that the Radix Angelicae Dahuricae has bonding tendency in mixing apparatus.Have been surprisingly found that, after the Radix Angelicae Dahuricae and appropriate Polyethylene Glycol are pre-mixed, then with other mixing of materials, can overcome above-mentioned bonding tendency.
Second aspect present invention provides a kind of for example method of wound curative capsule described in first aspect present invention any one of wound curative capsule of preparing, and the method comprises the following steps: get Radix Aconiti Coreani, Rhizoma Arisaematis, the Radix Angelicae Dahuricae, Radix Saposhnikoviae and Rhizoma Et Radix Notopterygii, be ground into respectively fine powder for subsequent use; By abundant each material mixture, incapsulate, to obtain final product.
According to the method described in the arbitrary embodiment of second aspect present invention, the method comprises the following steps: get Radix Aconiti Coreani, Rhizoma Arisaematis, the Radix Angelicae Dahuricae, Radix Saposhnikoviae and Rhizoma Et Radix Notopterygii, be ground into respectively fine powder for subsequent use; The Radix Angelicae Dahuricae is fully mixed homogeneously with Polyethylene Glycol; By abundant each material mixture, incapsulate, to obtain final product.
According to the method described in the arbitrary embodiment of second aspect present invention, the weight proportion of wherein said five kinds of medical materials is:
Radix Aconiti Coreani 176 weight portions,
Rhizoma Arisaematis 15～45 weight portions,
The Radix Angelicae Dahuricae 5～25 weight portions,
Radix Saposhnikoviae 5～25 weight portions,
Rhizoma Et Radix Notopterygii 5～25 weight portions.
According to the method described in the arbitrary embodiment of second aspect present invention, the weight proportion of wherein said five kinds of medical materials is:
Radix Aconiti Coreani 176 weight portions,
Rhizoma Arisaematis 20～40 weight portions,
The Radix Angelicae Dahuricae 10～20 weight portions,
Radix Saposhnikoviae 10～20 weight portions,
Rhizoma Et Radix Notopterygii 10～20 weight portions.
According to the method described in the arbitrary embodiment of second aspect present invention, the weight proportion of wherein said five kinds of medical materials is:
Radix Aconiti Coreani 176 weight portions,
Rhizoma Arisaematis 25～35 weight portions,
The Radix Angelicae Dahuricae 12～18 weight portions,
Radix Saposhnikoviae 12～18 weight portions,
Rhizoma Et Radix Notopterygii 12～18 weight portions.
According to the method described in the arbitrary embodiment of second aspect present invention, the weight proportion of wherein said five kinds of medical materials is:
Radix Aconiti Coreani approximately 176 weight portions,
Rhizoma Arisaematis approximately 30 weight portions,
The Radix Angelicae Dahuricae approximately 15 weight portions,
Radix Saposhnikoviae approximately 15 weight portions,
Rhizoma Et Radix Notopterygii approximately 15 weight portions.
According to the method described in the arbitrary embodiment of second aspect present invention, the weight proportion of wherein said five kinds of medical materials is:
Radix Aconiti Coreani approximately 176 weight portions,
Rhizoma Arisaematis approximately 29 weight portions,
The Radix Angelicae Dahuricae approximately 15 weight portions,
Radix Saposhnikoviae approximately 15 weight portions,
Rhizoma Et Radix Notopterygii approximately 15 weight portions.
According to the method described in the arbitrary embodiment of second aspect present invention, the weight proportion of wherein said five kinds of medical materials is:
Radix Aconiti Coreani approximately 176 weight portions,
Rhizoma Arisaematis approximately 31 weight portions,
The Radix Angelicae Dahuricae approximately 17 weight portions,
Radix Saposhnikoviae approximately 13 weight portions,
Rhizoma Et Radix Notopterygii approximately 15 weight portions.
According to the method described in the arbitrary embodiment of second aspect present invention, the weight proportion of wherein said five kinds of medical materials is:
Radix Aconiti Coreani approximately 176 weight portions,
Rhizoma Arisaematis approximately 29 weight portions,
The Radix Angelicae Dahuricae approximately 16 weight portions,
Radix Saposhnikoviae approximately 15 weight portions,
Rhizoma Et Radix Notopterygii approximately 14 weight portions.
According to the method described in the arbitrary embodiment of second aspect present invention, wherein said Polyethylene Glycol is that molecular weight is 2000～20000 Polyethylene Glycol.In one embodiment, described Polyethylene Glycol is that molecular weight is 4000～10000 Polyethylene Glycol.In one embodiment, described Polyethylene Glycol is that molecular weight is 4000～8000 Polyethylene Glycol.
According to the wound curative capsule described in the arbitrary embodiment of first aspect present invention, wherein, for Radix Aconiti Coreani 176 weight portions, the amount of described Polyethylene Glycol is 1～20 weight portion, for example 2～15 weight portions, for example 2～10 weight portions, for example 2～8 weight portions.
Arbitrary technical characterictic that arbitrary embodiment of either side of the present invention or this either side has is suitable for arbitrary embodiment of other arbitrary embodiment or other either side equally, as long as they can be not conflicting, certainly, at where applicable each other, necessary words can be done suitably to modify to individual features.Be further described with feature to various aspects of the present invention below.
All documents that the present invention quotes from, their full content is incorporated to herein by reference, and if when the expressed implication of these documents and the present invention are inconsistent, be as the criterion with statement of the present invention.In addition, various terms and phrase that the present invention uses have the general sense of well known to a person skilled in the art, nonetheless, the present invention still wishes at this, these terms and phrase to be described in more detail and to be explained, the term of mentioning and phrase, if any inconsistent with known implication, are as the criterion with the implication that the present invention was explained.
Existing wound curative capsule is on the basis of ancient prescription " Yuzhen San ", to various medical materials in prescription, according to the different screenings meticulously of its property of medicine, effect, carries out that rational formula makes.Thereby the shortcomings such as the numb tongue, bitter in the mouth, the dosage that have overcome original dosage form are inaccurate.Wound curative capsule, through a large amount of clinical verifications, to soft tissue injury, damages, and the diseases such as rheumatism, rheumatoid bone injury have unique curative effect; Also fine to associated conditions effects such as hypochondrium pain with internal injury, lumbar muscle strain, scapulohumeral periarthritis, arthralgia, be a kind of efficient, safe, desirable pure Chinese medicinal preparation.The treatment with dispelling wind-evil and transforming calculus, reducing swelling and alleviating pain effect hinders that capsule is red and swollen for wound outside due to traumatic injury, hypochondrium pain with internal injury, and its pharmacological action comprises: 1, regulate whole body or local blood illusory, to improve the metabolism status of diseased region; 2, the function that regulates blood coagulation and anticoagulation system, has dual regulation; 3, suppress inflammatory reaction, reduce the generation of inflammatory cut-off and the induced pain factor, slow down pain; 4, promote pathological changes reparation and tissue regeneration.
Radix Aconiti Coreani of the present invention is dry daughter root and the parent root of cohosh Aconitum carmichjaelii Debx. Aconitum coreanum (Levl.) Raip, and nature and flavor are hot, enters the heart, spleen, kidney channel; There is recuperating depleted YANG and rescuing the patient from collapse, dispelling cold by warming the meridian, the function of pain relieving.
Rhizoma Arisaematis of the present invention is the dry tuber of herbaceos perennial Rhizoma Arisaematis Arisaema erubescens (Wall.) Schott., Arisaema heterophyllum B1. Arisaema heterophyllum BL., arisaema amurense Maxim Arisaema amurense Maxim. or Rhizoma pinelliae pedatisectae Pinellia pedaeisecta Schott, nature and flavor hardship, pungent, warm, return liver, spleen channel: there is drying dampness to eliminate phlegm, expelling wind for relieving convulsion, dispersing swelling and dissipating binds pain-relieving functions.
The Radix Angelicae Dahuricae of the present invention is the dry root of samphire Radix Angelicae Dahuricae Angelica dahurica (Fishch.ex Hoffm.) Benth.ethook.f. or Radix angelicae dahuricae, and nature and flavor are pungent, warm, attach to the lung and stomach meridians; There is dispeiling pathogenic wind and removing dampness, the function of reducing swelling and alleviating pain.As usually join Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae with wind-expelling pain-stopping.
Radix Saposhnikoviae of the present invention is umbelliferae Saposhnikovia divaricata Saposhnikovia divaricata (Turcz.) Schischk. dry root, and nature and flavor acrid, sweet, warm, return bladder, lung, spleen channel; There is expelling pathogenic wind from the body surface, the function of removing dampness to relieve pain.
Rhizoma Et Radix Notopterygii of the present invention is dry rhizome and the root of samphire Rhizoma Et Radix Notopterygii Notopterygium incisum TingexH.T.Chang or broad-leaved Rhizoma Et Radix Notopterygii Notopterygium forbesii Boiss., and nature and flavor are pungent, bitter, and temperature is returned bladder, Liver Channel; Have and induce sweat, cold expelling, wind-damp dispelling, the function of pain relieving, for exterior syndrome due to wind-cold, anemofrigid-damp arthralgia, the diseases such as arthralgia.
In a word, the present invention can be used for treating raw Radix Aconiti Coreani in the capsule of traumatic injury can temperature sun, dispelling cold and dampness all over the body with warming the interior cold expelling, thereby can be used for cold-evil's invasion, disease due to cold-damp wins partially, and the Radix Saposhnikoviae of expelling wind and cold (containing volatile oil), the Radix Angelicae Dahuricae (containing Radix Angelicae Dahuricae element), Rhizoma Et Radix Notopterygii (containing volatile oil), warming for resolving cold-phlegm class medicine system Pu star (main containing benzoic acid) are ministerial drug, can wind-damp dispelling, stopping numbness pain, relieving convulsion, the detumescence function of the Radix Angelicae Dahuricae more so, Rhizoma Arisaematis (processed) have eliminate the phlegm, effect of dampness, removing toxic substances.Whole prescription the monarch and his subjects help mutually, and expectorant has the merit of blood stasis dispelling, and the medicine that dispels the wind also has the effect of circulation of qi promoting; Its Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii can make the sensible whole body of the property of medicine by priming again.Therefore for soft tissue injury, the aseptic inflammation of the various tissues such as rheumatism, rheumatoid disease, bone injury, scapulohumeral periarthritis, and all kinds of blood stasis is pain caused all effective in cure.
Detailed description of the invention
Further illustrate the present invention below by specific embodiment/experimental example, still, should be understood to, these embodiment and experimental example are only used for the use specifically describing more in detail, and should not be construed as for limiting in any form the present invention.
The present invention carries out generality and/or concrete description to the material and the test method that use in test.Although be well known in the art for realizing many materials and the operational approach that the object of the invention uses, the present invention still does to describe in detail as far as possible at this.It will be apparent to those skilled in the art that hereinafter, if not specified, material therefor of the present invention and operational approach are well known in the art.
In the time that the present invention below prepares capsule; every batch of material raw Radix Aconiti Coreani crude drug amount comprising that feeds intake is 17.6kg; other medical material is determined with the proportionate relationship between them as the case may be; and in the time preparing capsule, add appropriate amount of auxiliary materials; the dose comprising in institute's gained total particle or total every 250mg of powder is counted 176mg by raw Radix Aconiti Coreani crude drug amount; every capsules loading amount is counted 250mg with total particle or total powder, and the dose comprising in every capsules is counted 176mg by raw Radix Aconiti Coreani crude drug amount.In instantiation below, while mentioning Radix Aconiti Coreani, the raw Radix Aconiti Coreani of system, is Rhizoma Arisaematis (processed) while mentioning Rhizoma Arisaematis.
preparation example 1: prepare wound curative capsule of the present invention
Formula: the PEG6000 of Radix Aconiti Coreani 176 weight portions, Rhizoma Arisaematis 30 weight portions, the Radix Angelicae Dahuricae 15 weight portions, Radix Saposhnikoviae 15 weight portions, Rhizoma Et Radix Notopterygii 15 weight portions and 5 weight portions.
Method for making: get Radix Aconiti Coreani, Rhizoma Arisaematis, the Radix Angelicae Dahuricae, Radix Saposhnikoviae and Rhizoma Et Radix Notopterygii, be ground into respectively fine powder for subsequent use; The PEG that is ground in advance fine powder is mixed homogeneously in mixer with the Radix Angelicae Dahuricae; By each powder abundant mix homogeneously (method mensuration Radix Aconiti Coreani total alkaloid content of recording according to CN101785818A description [0007] section in mixer, and measure Guan-fubase B content in capsule according to CN101785818A description [0099]～[0104] section HPLC method, determine mixing uniformity with this total alkaloids and two indexs of Guan-fubase B).
According to the method in the assay in one 97 pages " Radix Angelicae Dahuricae " kinds of Chinese Pharmacopoeia version in 2010, measure the amount (mg/g of the Radix Angelicae Dahuricae in eventually mixed powder, scale with imperatorin shows, be labeled as " BZ1 "), in addition by the material being emptied in mixer, clean the powder (can be described as in the present invention " residual powder ") that its inwall is sticky with, measure the amount (mg/g of the Radix Angelicae Dahuricae in this powder, scale with imperatorin shows, be labeled as " BZ2 "), in calculating residual powder, the Radix Angelicae Dahuricae is with respect to Radix Angelicae Dahuricae amount in eventually mixed powder, be designated as Radix Angelicae Dahuricae relative quantity in residual powder, calculating formula is:
Radix Angelicae Dahuricae relative quantity=(BZ2 ÷ BZ1) × 100%
In this preparation example 1, Radix Angelicae Dahuricae relative quantity is 98.4%, close to 100%, shows that the Radix Angelicae Dahuricae amount in eventually mixed powder and residual powder is suitable.
preparation example 2: prepare wound curative capsule of the present invention
Formula: the PEG4000 of Radix Aconiti Coreani 176 weight portions, Rhizoma Arisaematis 29 weight portions, the Radix Angelicae Dahuricae 15 weight portions, Radix Saposhnikoviae 15 weight portions, Rhizoma Et Radix Notopterygii 15 weight portions and 8 weight portions.Prepare capsule with reference to preparation example 1 technique.
preparation example 3: prepare wound curative capsule of the present invention
Formula: the PEG8000 of Radix Aconiti Coreani 176 weight portions, Rhizoma Arisaematis 31 weight portions, the Radix Angelicae Dahuricae 17 weight portions, Radix Saposhnikoviae 13 weight portions, Rhizoma Et Radix Notopterygii 15 weight portions and 2 weight portions.Prepare capsule with reference to preparation example 1 technique.
preparation example 4: prepare wound curative capsule of the present invention
Formula: the PEG6000 of Radix Aconiti Coreani 176 weight portions, Rhizoma Arisaematis 29 weight portions, the Radix Angelicae Dahuricae 16 weight portions, Radix Saposhnikoviae 15 weight portions, Rhizoma Et Radix Notopterygii 14 weight portions and 4 weight portions.Prepare capsule with reference to preparation example 1 technique.
preparation example 5: prepare wound curative capsule of the present invention
Formula: the PEG6000 of Radix Aconiti Coreani 176 weight portions, Rhizoma Arisaematis 20 weight portions, the Radix Angelicae Dahuricae 20 weight portions, Radix Saposhnikoviae 10 weight portions, Rhizoma Et Radix Notopterygii 20 weight portions and 7 weight portions.Prepare capsule with reference to preparation example 1 technique.
preparation example 6: prepare wound curative capsule of the present invention
Formula: the PEG5000 of Radix Aconiti Coreani 176 weight portions, Rhizoma Arisaematis 40 weight portions, the Radix Angelicae Dahuricae 10 weight portions, Radix Saposhnikoviae 20 weight portions, Rhizoma Et Radix Notopterygii 10 weight portions and 6 weight portions.Prepare capsule with reference to preparation example 1 technique.
preparation example 7: prepare wound curative capsule of the present invention
Formula: the PEG7000 of Radix Aconiti Coreani 176 weight portions, Rhizoma Arisaematis 25 weight portions, the Radix Angelicae Dahuricae 18 weight portions, Radix Saposhnikoviae 12 weight portions, Rhizoma Et Radix Notopterygii 18 weight portions and 4 weight portions.Prepare capsule with reference to preparation example 1 technique.
preparation example 8: prepare wound curative capsule of the present invention
Formula: the PEG6000 of Radix Aconiti Coreani 176 weight portions, Rhizoma Arisaematis 35 weight portions, the Radix Angelicae Dahuricae 12 weight portions, Radix Saposhnikoviae 18 weight portions, Rhizoma Et Radix Notopterygii 12 weight portions and 2 weight portions.Prepare capsule with reference to preparation example 1 technique.
Above preparation example 2-8 is prepared in capsule process, and Radix Angelicae Dahuricae relative quantity all, in 98～102% scopes, close to 100%, shows that the Radix Angelicae Dahuricae amount in eventually mixed powder and residual powder is suitable.
reference examples 1～8: prepare wound curative capsule
Prepare capsule with reference to formula and the method for above preparation example 1-8 respectively, different is only not add Polyethylene Glycol.As a result in 8 batches of preparation manipulations, Radix Angelicae Dahuricae relative quantity is all in 195～240% scopes, for example, with reference to the method for preparation example 1 but do not add Polyethylene Glycol, in Radix Angelicae Dahuricae relative quantity 211%.
reference examples 9: prepare wound curative capsule
According to CN101785818A (Chinese Patent Application No. 201010138372.2, the method that Zhu Yangxin) description [0029] section is recorded is prepared capsule, result Radix Angelicae Dahuricae relative quantity reaches 223%, shows that the amount of the Radix Angelicae Dahuricae in residual powder is higher than the amount of mixing the Radix Angelicae Dahuricae in powder end of large batch.This is for the lower powder of relative quantity in mixed material, and so large loss is completely unacceptable.
reference examples 10: prepare wound curative capsule
According to CN1883630A (Chinese Patent Application No. 200610051843.X, Zhu Yangxin) 2/5 page of capable method of 7-4 reciprocal of description is prepared capsule, each material proportion is Radix Aconiti Coreani 176 weight portions, Rhizoma Arisaematis 30 weight portions, the Radix Angelicae Dahuricae 15 weight portions, Radix Saposhnikoviae 15 weight portions, Rhizoma Et Radix Notopterygii 15 weight portions, and result Radix Angelicae Dahuricae relative quantity reaches 206%.
reference examples 11: prepare wound curative capsule
With reference to the method for preparation example 1 of the present invention, that different is PEG 1000, PEG 1500, PEG 2000 or the PEG 3000 that Polyethylene Glycol is wherein changed into equivalent, result is presented in these four batches of capsules of preparation, Radix Angelicae Dahuricae relative quantity reaches more than 185%, and the lower Radix Angelicae Dahuricae relative quantity of molecular weight is higher, demonstration molecular weight can not be realized the object of the invention lower than 3000 PEG.
reference examples 12: prepare wound curative capsule
With reference to the method for preparation example 1 of the present invention, different is to change Polyethylene Glycol consumption wherein into 0.5 weight portion, 1.0 weight portions or 1.5 weight portions, result is presented in these three batches of capsules of preparation, Radix Angelicae Dahuricae relative quantity reaches more than 170%, and the lower Radix Angelicae Dahuricae relative quantity of Polyethylene Glycol consumption is higher, shows when PEG consumption is lower and can not realize the object of the invention.
reference examples 13: prepare wound curative capsule
With reference to the method for preparation example 1 of the present invention, different is stearic acid, magnesium stearate, Pulvis Talci or the micropowder silica gel that Polyethylene Glycol is wherein changed into equivalent, and result is presented in these four batches of capsules of preparation, and Radix Angelicae Dahuricae relative quantity is all in 205～220% scopes.
reference examples 14: prepare wound curative capsule
With reference to the method for preparation example 1 of the present invention, that different is PEG10000, the PEG20000 that Polyethylene Glycol is wherein changed into equivalent, result is presented at these two batches of capsules of preparation and at room temperature places after 1 year and in original flowable powder, to form caking, and caking is difficult to scatter with sieve method fragmentation.Equally at room temperature place 1 year, have been found that the present invention above preparation example 1～8 gained capsule have no caking phenomenon.
reference examples 15: prepare wound curative capsule
With reference to the method for preparation example 1 of the present invention, different is to change Polyethylene Glycol consumption wherein into 12 weight portions, 20 weight portions, 30 weight portions, result is presented at these three batches of capsules of preparation and at room temperature places after 1 year and in original flowable powder, to form caking, and caking is difficult to scatter with sieve method fragmentation.
reference examples 16: prepare wound curative capsule
With reference to the method for preparation example 1 of the present invention, the Polyethylene Glycol that different is wherein together mixes and does not mix with the Radix Angelicae Dahuricae separately in advance with other material.Result Radix Angelicae Dahuricae relative quantity, all 210%, shows that this operation sequence can not overcome the problem that the Radix Angelicae Dahuricae adheres to.
test example 1: the biologic activity of measuring wound curative capsule
Reagent: preparation example 1,2 capsules and reference examples 9 capsules, commercially available wound curative capsule (the accurate word Z10920013 of traditional Chinese medicines; the tolerant 250mg of every intragranular; Radix Aconiti Coreani crude drug is wherein 176mg), dosage is all used each capsule particle or powder 1.5g with every kg the weight of animals.Negative control group and positive controls are pressed respectively literature method setting.
With reference to CN1883630A (Chinese Patent Application No. 200610051843.X, Zhu Yangxin) the mouse auricle swelling test (test one) in Instructions Page 2 test 1, test the impact that each reagent xylol causes mice auricle swelling, suppress percent in swelling,, swelling suppresses percent=[the negative contrast groups swelling of (negative contrast groups swelling-administration group swelling) ÷] × 100%.Result shows, the swelling of preparation example 1,2 capsules and reference examples 9 capsules, commercially available wound curative capsule suppresses percent all in 46～54% scopes, and more all there were significant differences with negative contrast groups, p<0.01, it is 52% that for example swelling of preparation example 1 capsule of the present invention suppresses percent.
With reference to CN1883630A (Chinese Patent Application No. 200610051843.X, Zhu Yangxin) the method in description page 4 test 2, test the impact of each reagent on mice autonomic activities, computational activity number of times reduces percent, and movable number of times reduces percent=[the negative contrast groups activity of (negative contrast groups activity number of times-administration group activity number of times) ÷ number of times] × 100%.Result shows, the movable number of times of preparation example 1,2 capsules and reference examples 9 capsules, commercially available wound curative capsule reduces percent all in 23～27% scopes, and more all there were significant differences with negative contrast groups, p<0.01, it is 25% that the movable number of times of for example preparation example 2 capsules of the present invention reduces percent.
With reference to the method in CN1883630A (Chinese Patent Application No. 200610051843.X, Zhu Yangxin) description page 4 test 3, test each reagent Dichlorodiphenyl Acetate and cause the impact of mouse writhing number of times, calculate analgesia percentage rate.Result shows, the analgesia percentage rate of preparation example 1,2 capsules and reference examples 9 capsules, commercially available wound curative capsule is all in 37～43% scopes, and more all there were significant differences with negative contrast groups, p<0.01, for example the analgesia percentage rate of preparation example 2 capsules of the present invention is 39%.
Above three biological test results show, capsule of the present invention is the same with existing product all has good biologic activity, is applicable to clinical treatment traumatic injury, various soft tissue injury, strain, skin injury, internal injury; Rheumatic arthritis; The various aseptic inflammations of organizing such as scapulohumeral periarthritis, chondritis, synovitis, tenosynovitis; The pain that the degeneration of joint such as hyperosteogeny, cervical spondylotic radiculopathy causes; Lumbago and skelalgia, sciatica, arthralgia, cervical vertebra pain.
Claims (15)
1. a wound curative capsule, its medical material by following weight proportion is made: Radix Aconiti Coreani 176 weight portions, Rhizoma Arisaematis 15 ~ 45 weight portions, the Radix Angelicae Dahuricae 5 ~ 25 weight portions, Radix Saposhnikoviae 5 ~ 25 weight portions, Rhizoma Et Radix Notopterygii 5 ~ 25 weight portions; In this wound curative capsule, also comprise that molecular weight is 4000 ~ 8000 Polyethylene Glycol, for Radix Aconiti Coreani 176 weight portions, the amount of Polyethylene Glycol is 2 ~ 8 weight portions; This wound curative capsule prepares according to following method: get Radix Aconiti Coreani, Rhizoma Arisaematis, the Radix Angelicae Dahuricae, Radix Saposhnikoviae and Rhizoma Et Radix Notopterygii, be ground into respectively fine powder for subsequent use; The Radix Angelicae Dahuricae is fully mixed homogeneously with Polyethylene Glycol; By abundant each material mixture, incapsulate, to obtain final product.
2. according to the wound curative capsule of claim 1, its medical material by following weight proportion is made: Radix Aconiti Coreani 176 weight portions, Rhizoma Arisaematis 20 ~ 40 weight portions, the Radix Angelicae Dahuricae 10 ~ 20 weight portions, Radix Saposhnikoviae 10 ~ 20 weight portions, Rhizoma Et Radix Notopterygii 10 ~ 20 weight portions.
3. according to the wound curative capsule of claim 1, its medical material by following weight proportion is made: Radix Aconiti Coreani 176 weight portions, Rhizoma Arisaematis 25 ~ 35 weight portions, the Radix Angelicae Dahuricae 12 ~ 18 weight portions, Radix Saposhnikoviae 12 ~ 18 weight portions, Rhizoma Et Radix Notopterygii 12 ~ 18 weight portions.
4. according to the wound curative capsule of claim 1, its medical material by following weight proportion is made: Radix Aconiti Coreani 176 weight portions, Rhizoma Arisaematis 30 weight portions, the Radix Angelicae Dahuricae 15 weight portions, Radix Saposhnikoviae 15 weight portions, Rhizoma Et Radix Notopterygii 15 weight portions.
5. according to the wound curative capsule of claim 1, its medical material by following weight proportion is made: its medical material by following weight proportion is made: Radix Aconiti Coreani 176 weight portions, Rhizoma Arisaematis 29 weight portions, the Radix Angelicae Dahuricae 15 weight portions, Radix Saposhnikoviae 15 weight portions, Rhizoma Et Radix Notopterygii 15 weight portions.
6. according to the wound curative capsule of claim 1, its medical material by following weight proportion is made: its medical material by following weight proportion is made: Radix Aconiti Coreani 176 weight portions, Rhizoma Arisaematis 31 weight portions, the Radix Angelicae Dahuricae 17 weight portions, Radix Saposhnikoviae 13 weight portions, Rhizoma Et Radix Notopterygii 15 weight portions.
7. according to the wound curative capsule of claim 1, its medical material by following weight proportion is made: its medical material by following weight proportion is made: Radix Aconiti Coreani 176 weight portions, Rhizoma Arisaematis 29 weight portions, the Radix Angelicae Dahuricae 16 weight portions, Radix Saposhnikoviae 15 weight portions, Rhizoma Et Radix Notopterygii 14 weight portions.
8. according to the wound curative capsule of claim 1, wherein said Radix Aconiti Coreani is directly pulverized gained powder with it and is added in described wound curative capsule.
9. according to the wound curative capsule of claim 1, wherein said Rhizoma Arisaematis is Rhizoma Arisaematis (processed).
10. according to the wound curative capsule of claim 1, wherein said Rhizoma Arisaematis is directly pulverized gained powder with it and is added in described wound curative capsule.
11. according to the wound curative capsule of claim 1, and the wherein said Radix Angelicae Dahuricae is directly pulverized gained powder with it and added in described wound curative capsule.
12. according to the wound curative capsule of claim 1, and wherein said Radix Saposhnikoviae is directly pulverized gained powder with it and adds in described wound curative capsule.
13. according to the wound curative capsule of claim 1, and wherein said Rhizoma Et Radix Notopterygii is directly pulverized gained powder with it and adds in described wound curative capsule.
14. according to the wound curative capsule of claim 1, and wherein said Radix Aconiti Coreani is raw Radix Aconiti Coreani.
The method of the wound curative capsule of 15. preparation claim 1 ~ 14 any one, the method comprises the following steps: get Radix Aconiti Coreani, Rhizoma Arisaematis, the Radix Angelicae Dahuricae, Radix Saposhnikoviae and Rhizoma Et Radix Notopterygii, be ground into respectively fine powder for subsequent use; The Radix Angelicae Dahuricae is fully mixed homogeneously with Polyethylene Glycol; By abundant each material mixture, incapsulate, to obtain final product.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1883630A (en) * | 2006-06-07 | 2006-12-27 | 杭州朱养心药业有限公司 | Oral liquid for treating traumatic injury and method for preparing same |
| CN101785818A (en) * | 2010-03-19 | 2010-07-28 | 杭州朱养心药业有限公司 | Content determination method for active ingredients of wound curative capsule |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1883630A (en) * | 2006-06-07 | 2006-12-27 | 杭州朱养心药业有限公司 | Oral liquid for treating traumatic injury and method for preparing same |
| CN101785818A (en) * | 2010-03-19 | 2010-07-28 | 杭州朱养心药业有限公司 | Content determination method for active ingredients of wound curative capsule |
Non-Patent Citations (1)
| Title |
|---|
| 郑永周，等.中医药外治急性软组织损伤的研究现况及进展.《光明中医》.2013,第28卷(第3期),第626-628页. * |
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