CN1879615A - 抗肿瘤的协同药物组合物 - Google Patents
抗肿瘤的协同药物组合物 Download PDFInfo
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- CN1879615A CN1879615A CN 200610006556 CN200610006556A CN1879615A CN 1879615 A CN1879615 A CN 1879615A CN 200610006556 CN200610006556 CN 200610006556 CN 200610006556 A CN200610006556 A CN 200610006556A CN 1879615 A CN1879615 A CN 1879615A
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- Prior art keywords
- yellow
- tumor
- baicalin
- cisplatin
- baicaligenin
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Abstract
Description
单剂药物作用浓度(μm) | 联合药物作用浓度(μm) | 细胞生长抑制率(%) | 联合用药系数值(CI) |
黄元2.5 | 0.2 | ||
黄元5 | 17.43±1.2 | ||
黄元10 | 40.5±2 | ||
黄元20 | 59.8±3 | ||
黄元40 | 91±2.5 | ||
黄甙5 | 0.1 | ||
黄甙10 | 5±0.2 | ||
黄甙20 | 25.2±2 | ||
黄甙40 | 75.2±3 | ||
Pt 1 | 2±0.5 | ||
Pt 2 | 30±3 | ||
Pt 4 | 33±3 | ||
Pt 8 | 77.5±2.5 | ||
Pt 1+黄元2.5 | 5±2 | 1.32 | |
Pt 2+黄元5 | 37.8±3 | 0.96 | |
Pt 4+黄元10 | 95±2.7 | 0.47 | |
Pt 1+黄元5 | 21.2±2 | 0.78 |
Pt 2+黄元10 | 42.9±3 | 0.98 | |
Pt 4+黄元20 | 85±2 | 0.98 | |
Pt 1+黄元10 | 35±3 | 0.9 | |
Pt 2+黄元20 | 73.3±1.2 | 0.98 | |
Pt 4+黄元40 | 95.5±2 | 0.88 | |
Pt 1+黄甙7.5 | 10±1.5 | 1.07 | |
Pt 2+黄甙15 | 59.2±2.5 | 0.875 | |
Pt 4+黄甙30 | 92±3 | 0.85 | |
Pt 1+黄甙10 | 11.2±2 | 1.2 | |
Pt 2+黄甙20 | 65±3 | 0.958 | |
Pt 4+黄甙40 | 95±2 | 0.9 |
单剂药物作用浓度(μm) | 联合药物作用浓度(μm) | 细胞生长抑制率% | 联合用药系数值(CI) |
黄元5 | 24.43±1.5 | ||
黄元10 | 35.933±3 | ||
黄元20 | 57.02±2 | ||
黄元40 | 72±1 | ||
黄甙5 | 27.62±2 | ||
黄甙10 | 33.25±2 | ||
黄甙20 | 37.65±3 | ||
黄甙40 | 68.7±3 | ||
Pt 1 | 5±0.5 | ||
Pt 2 | 27.33±2 | ||
Pt 4 | 61.18±3 | ||
Pt 2+黄元5 | 47.52±2 | 0.99 | |
Pt 4+黄元10 | 83.9±3 | 0.766 | |
Pt 8+黄元20 | 97.5±2 | 0.6 |
Pt 1+黄元5 | 29.8±3 | 1.17 | |
Pt 2+黄元10 | 60±3 | 0.95 | |
Pt 4+黄元20 | 90±3 | 0.658 | |
Pt 1+黄元10 | 58.2±1.5 | 0.729 | |
Pt 2黄元20 | 75±2 | 0.83 | |
Pt 4+黄元40 | 98 | 0.3 | |
Pt 1+黄甙5 | 28.75±2 | 1.1 | |
Pt 2+黄甙10 | 62.9±3.2 | 0.736 | |
Pt 4+黄甙20 | 88±2 | 0.626 | |
Pt 1+黄甙10 | 44.32±3 | 0.95 | |
Pt 2+黄甙20 | 67.76±1.2 | 0.85 | |
Pt 4+黄甙40 | 95±2 | 0.42 |
单剂药物作用浓度(μm) | 联合药物作用浓度(μm) | 细胞生长抑制率% | 联合用药系数值(CI) |
黄元5 | 1±0.5 | ||
黄元10 | 17.43±3 | ||
黄元20 | 38±2 | ||
黄元40 | 91.2±1 | ||
黄甙5 | 5±1 | ||
黄甙10 | 10.3±2 | ||
黄甙20 | 35.8±2 | ||
黄甙40 | 62.1±3 | ||
Pt 1 | 31±2.5 | ||
Pt 2 | 42.3±3 | ||
Pt 4 | 49±3 | ||
Pt 1+黄元2.5 | 15±2 | 5.8 | |
Pt 2+黄元5 | 52.5±3 | 0.661 |
Pt 4+黄元10 | 66±3 | 0.677 | |
Pt 1+黄元5 | 19±1 | 3.7 | |
Pt 2+黄元10 | 59.5±2.5 | 0.69 | |
Pt 4+黄元20 | 90.2±2 | 0.515 | |
Pt 1+黄元10 | 67±3 | 0.47 | |
Pt 2+黄元20 | 85±2 | 0.6 | |
Pt 4+黄元40 | 95±2 | 0.79 | |
Pt 1+黄甙7.5 | 26.7±2 | 2 | |
Pt 2+黄甙15 | 55.7±3.1 | 0.762 | |
Pt 4+黄甙30 | 78±2 | 0.578 | |
Pt 1+黄甙10 | 29.8±2.1 | 1.15 | |
Pt 2+黄甙20 | 61.9±2.1 | 0.7025 | |
Pt 4+黄甙40 | 82.7±3 | 0.6 |
单剂药物作用浓度(μm) | 联合药物作用浓度(μm) | 细胞生长抑制率% | 联合用药系数值(CI) |
黄元1 | 5±0.5 | ||
黄元2 | 17.6±2 | ||
黄元4 | 21.5±2 | ||
黄元8 | 43±3 | ||
黄元16 | 51.25±3 | ||
黄甙2.5 | 0.01 | ||
黄甙5 | 23.6±2 | ||
黄甙10 | 40.25±3 | ||
黄甙20 | 47.87±3 | ||
黄甙40 | 82.78±3 | ||
Pt 1 | 5±0.5 | ||
Pt 2 | 29.67±3 |
Pt 4 | 43.3±3 | ||
Pt 8 | 51.5±2.5 | ||
Pt 1+黄元1 | 10.02±2 | 1.8 | |
Pt 2+黄元2 | 37±3 | 0.769 | |
Pt 4+黄元4 | 55±2 | 0.88 | |
Pt 8+黄元8 | 77.12±2 | 0.7727 | |
Pt 1+黄元2.5 | 19±3 | 1.28 | |
Pt 2+黄元5 | 55±2 | 0.628 | |
Pt 4+黄元10 | 65±3 | 0.8838 | |
Pt 1+黄元5 | 22.2±2 | 1.26 | |
Pt 2+黄元10 | 57±2 | 0.89 | |
Pt 4+黄元20 | 85±2 | 0.505 | |
Pt 1+黄元10 | 52±3 | 0.9 | |
Pt 2+黄元20 | 82±3 | 0.49 | |
Pt 4+黄元40 | 95±2 | 0.272 | |
Pt 1+黄甙2.5 | 10.2±2 | 1.0625 | |
Pt 2+黄甙5 | 51.3±3 | 0.605 | |
Pt 4+黄甙10 | 67.2±2 | 0.863 | |
Pt 1+黄甙5 | 23.22±3 | 0.783 | |
Pt 2+黄甙10 | 55.35±1.2 | 0.819 | |
Pt 4+黄甙20 | 85±2 | 0.91 | |
Pt 1+黄甙10 | 45.65±2 | 0.772 | |
Pt 2+黄甙20 | 76.7±3 | 0.4825 | |
Pt 4+黄甙40 | 95±2 | 1 |
单剂药物作用浓度(μm) | 联合药物作用浓度(μm) | 细胞生长抑制率% | 联合用药系数值(CI) |
黄元5 | 0.9 |
黄元10 | 16.8±1.7 | ||
黄元20 | 49±2 | ||
黄元40 | 91.3±3 | ||
黄甙5 | 1 | ||
黄甙10 | 9±1 | ||
黄甙20 | 45.2±3 | ||
黄甙40 | 71.2±3 | ||
Pt 1 | 8.8±0.5 | ||
Pt 2 | 31.99±3 | ||
Pt 4 | 44.42±3 | ||
Pt 8 | 75±2.5 | ||
Pt 1+黄元2.5 | 12±3 | 1.13 | |
Pt 2+黄元5 | 32.2±2 | 1.12 | |
Pt 4+黄元10 | 70±2.7 | 0.98 | |
Pt 8+黄元20 | 92±3 | 0.91 | |
Pt 1+黄元5 | 22±2 | 0.95 | |
Pt 2+黄元10 | 52±2 | 0.988 | |
Pt 4+黄元20 | 86±3 | 0.91 | |
Pt 1+黄元10 | 38±3 | 0.95 | |
Pt 2+黄元20 | 71±3 | 0.99 | |
Pt 4+黄元40 | 95±4.2 | 0.932 | |
Pt 1+黄甙5 | 11±1 | 0.9 | |
Pt 2+黄甙10 | 49.5±3 | 0.9 | |
Pt 4+黄甙20 | 82.35±3 | 0.82 | |
Pt 1+黄甙10 | 32.5±2.5 | 0.926 | |
Pt 2+黄甙20 | 69.8±3 | 0.876 | |
Pt 4+黄甙40 | 95±2 | 0.69 |
分组 | 剂量mg/kg | 给药日程 | 体重减少率% | 瘤重(g)均值±SD | 抑瘤率% | 动物数(只)始/末 |
对照组 | - | <0 | 2.63±0.27 | 10/10 | ||
顺铂 | 2 | 2-4,8-10 | <5 | 1.58±0.3 | 39.9 | 10/10 |
黄元 | 5 | 2-4,8-10 | <5 | 2.55±0.3 | 3 | 10/10 |
黄元 | 10 | 2-4,8-10 | <5 | 2.35±0.187 | 10.6 | 10/10 |
黄元 | 20 | 2-4,8-10 | <5 | 2.22±0.225 | 15.58 | 10/10 |
黄甙 | 8.25 | 2-4,8-10 | <5 | 2.57±0.18 | 2.2 | 10/10 |
黄甙 | 16.5 | 2-4,8-10 | <5 | 2.37±0.15 | 9.9 | 10/10 |
黄甙 | 33 | 2-4,8-10 | <5 | 2.23±0.12 | 15.2 | 10/10 |
顺铂+黄元 | 2+5 | 2-4,8-10 | <5 | 1.2±0.2 | 54.37** | 10/10 |
顺铂+黄元 | 2+10 | 2-4,8-10 | <5 | 1.15±0.2 | 56.27** | 10/10 |
顺铂+黄元 | 2+20 | 2-4,8-10 | <7 | 1.05±0.15 | 60** | 10/10 |
顺铂+黄甙 | 2+8.25 | 2-4,8-10 | <5 | 1.42±0.18 | 45.6 | 10/10 |
顺铂+黄甙 | 2+16.5 | 2-4,8-10 | <5 | 1.35±0.23 | 48.67* | 10/10 |
顺铂+黄甙 | 2+33 | 2-4,8-10 | <5 | 1.15±0.08 | 56.27** | 10/10 |
单剂药物作用浓度(μm) | 联合药物作用浓度(μm) | 细胞生长抑制率(%) | 联合用药系数值(CI) |
黄元2.5 | 0.2 | ||
黄元5 | 17.43±1.2 | ||
黄元10 | 40.5±2 | ||
黄元20 | 59.8±3 | ||
黄元40 | 91±2.5 | ||
黄甙5 | 0.1 | ||
黄甙10 | 5±0.2 | ||
黄甙20 | 25.2±2 | ||
黄甙40 | 75.2±3 | ||
5-Fu 5 | 8±2 | ||
5-Fu 10 | 20.2±3.5 | ||
5-Fu 20 | 48±2.78 | ||
5-Fu 40 | 87.72±1.7 | ||
5-Fu 10+黄元5 | 35±3 | 0.98 |
5-Fu 20+黄元10 | 69±2 | 1 | |
5-Fu 40+黄元20 | 95 | 0.85 | |
5-Fu 5+黄元5 | 18±2 | 0.755 | |
5-Fu 10+黄元10 | 48.2±2 | 0.98 | |
5-Fu 20+黄元20 | 88 | 0.98 | |
5-Fu 5+黄元10 | 35±3 | 0.95 | |
5-Fu 10+黄元20 | 75±3 | 0.98 | |
5-Fu 20+黄元40 | 98±3 | 0.79 | |
5-Fu 5+黄甙10 | 12±2.5 | 1.2 | |
5-Fu 10+黄甙20 | 77±2 | 0.85 | |
5-Fu 20+黄甙40 | 92.5±3 | 1 | |
5-Fu 2.5+黄甙10 | 11±1.5 | 0.962 | |
5-Fu 5+黄甙20 | 57±3 | 0.91 | |
5-Fu 10+黄甙40 | 91.7±3 | 0.947 |
单剂药物作用浓度(μm) | 联合药物作用浓度(μm) | 细胞生长抑制率% | 联合用药系数值(CI) |
黄元5 | 24.43±1.5 | ||
黄元10 | 35.933±3 | ||
黄元20 | 57.02±2 | ||
黄元40 | 72±1 | ||
黄甙5 | 27.62±2 | ||
黄甙10 | 33.25±2 | ||
黄甙20 | 37.65±3 | ||
黄甙40 | 68.7±3 | ||
5-Fu 5 | 25.8±2 | ||
5-Fu 10 | 61.5±3.5 | ||
5-Fu 20 | 68.5±2.78 |
5-Fu 2.5+黄元5 | 28.2±3 | 1.31 | |
5-Fu 5+黄元10 | 62.5±2 | 0.7 | |
5-Fu 10+黄元20 | 77.1±2.7 | 0.8 | |
5-Fu 20+黄元40 | 91.2±2.79 | 0.37 | |
5-Fu 2.5+黄元2.5 | 21.2±1.9 | 1.275 | |
5-Fu 5+黄元5 | 49.2±3 | 0.86 | |
5-Fu 10+黄元10 | 75.2±3 | 0.662 | |
5-Fu 20+黄元20 | 91.2±2.7 | 0.485 | |
5-Fu 5+黄元2.5 | 38±2.2 | 1 | |
5-Fu 10+黄元5 | 63.21±2 | 0.882 | |
5-Fu 20+黄元10 | 82.67±3.2 | 0.78 | |
5-Fu 2.5+黄甙2.5 | 20.5±2.5 | 1.37 | |
5-Fu 5+黄甙5 | 38.9±2 | 1.1 | |
5-Fu 10+黄甙10 | 75.2±3 | 0.56 | |
5-Fu 20+黄甙20 | 87.6±4 | 0.55 | |
5-Fu 2.5+黄甙5 | 23.7±2 | 1.49 | |
5-Fu 5+黄甙10 | 52.7±3 | 0.88 | |
5-Fu 10+黄甙20 | 82.65±3 | 0.45 |
单剂药物作用浓度(μm) | 联合药物作用浓度(μm) | 细胞生长抑制率% | 联合用药系数值(CI) |
黄元1 | 5±0.5 | ||
黄元2 | 17.6±2 | ||
黄元4 | 21.5±2 | ||
黄元8 | 43±3 | ||
黄元16 | 51.25±3 | ||
黄甙2.5 | 0.01 | ||
黄甙5 | 23.6±2 |
黄甙10 | 40.25±3 | ||
黄甙20 | 47.87±3 | ||
黄甙40 | 82.78±3 | ||
5-Fu 5 | 25.2±2 | ||
5-Fu 10 | 48.91±3.5 | ||
5-Fu 20 | 65.32±2.78 | ||
5-Fu 5+黄元2.5 | 29.8±2 | 1.32 | |
5-Fu 10+黄元5 | 61.8±3 | 0.84 | |
5-Fu 20+黄元10 | 82±3.2 | 0.7 | |
5-Fu 10+黄元5 | 95±2 | 0.42 | |
5-Fu 2.5+黄元2.5 | 22.5±3 | 1.23 | |
5-Fu 5+黄元5 | 47±3 | 0.92 | |
5-Fu 10+黄元10 | 72±3 | 0.727 | |
5-Fu 20+黄元20 | 87.8±2 | 0.6 | |
5-Fu 2.5+黄元5 | 29±2 | 1.38 | |
5-Fu 5+黄元10 | 61.5±3 | 0.8 | |
5-Fu 10黄元20 | 75±3 | 0.749 | |
5-Fu 2.5+黄甙2.5 | 17.2±3 | 0.9655 | |
5-Fu 5+黄甙5 | 37.7±3 | 0.9568 | |
5-Fu 10+黄甙10 | 71±3 | 0.857 | |
5-Fu 20+黄甙20 | 89.2±3 | 0.91 | |
5-Fu 2.5+黄甙5 | 28.2±2.7 | 0.81 | |
5-Fu 5+黄甙10 | 57.2±3 | 0.85 | |
5-Fu 10+黄甙20 | 81.5±3 | 0.98 |
单剂药物作用浓度(μm) | 联合药物作用浓度(μm) | 细胞生长抑制率% | 联合用药系数值(CI) |
黄元5 | 0.9 |
黄元10 | 16.8±1.7 | ||
黄元20 | 49±2 | ||
黄元40 | 91.3±3 | ||
黄甙5 | 1 | ||
黄甙10 | 9±1 | ||
黄甙20 | 45.2±3 | ||
黄甙40 | 71.2±3 | ||
5-Fu 5 | 7.2±2 | ||
5-Fu 10 | 13.9±3.5 | ||
5-Fu 20 | 39.08±2.78 | ||
5-Fu 40 | 44.2±1.7 | ||
5-Fu 5+黄元2.5 | 8±2.8 | 1.22 | |
5-Fu 10+黄元5 | 25.8±2 | 0.95 | |
5-Fu 20+黄元10 | 65.2±3 | 0.725 | |
5-Fu 40+黄元20 | 92.2±3 | 0.62 | |
5-Fu 5+黄元5 | 12.5±2 | 1.1 | |
5-Fu 10+黄元10 | 42.2±3 | 0.9 | |
5-Fu 20+黄元20 | 74.2±3 | 0.97 | |
5-Fu 5+黄元10 | 22.5±2 | 1.1 | |
5-Fu 10+黄元20 | 67±3 | 0.98 | |
5-Fu 20+黄元40 | 95±3 | 0.9 | |
5-Fu 5+黄甙5 | 11.2±1.5 | 1.12 | |
5-Fu 10+黄甙10 | 40.7±2 | 0.8 | |
5-Fu 20+黄甙20 | 75.5±3 | 0.717 | |
5-Fu 5+黄甙10 | 21.2±2 | 1 | |
5-Fu 10+黄甙20 | 65.8±3 | 0.767 | |
5-Fu 20+黄甙40 | 95±2 | 0.57 |
单剂药物作用浓度(μm) | 联合药物作用浓度(μm) | 细胞生长抑制率% | 联合用药系数值(CI) |
黄元2.5 | 1±0.5 | ||
黄元5 | 8.7±3 | ||
黄元10 | 37.7±2 | ||
黄元20 | 55.8±1 | ||
黄甙5 | 5±1 | ||
黄甙10 | 21.5±2 | ||
黄甙40 | 85.2±3 | ||
5-Fu 5 | 22.5±2 | ||
5-Fu 10 | 45.2±3 | ||
5-Fu 20 | 65.2±2 | ||
5-Fu 40 | 82.7±1.8 | ||
5-Fu 5+黄元2.5 | 25±3 | 1.18 | |
5-Fu 10+黄元5 | 55.8±2.2 | 0.97 | |
5-Fu 20+黄元10 | 82.1±2.1 | 0.83 | |
5-Fu 40+黄元20 | 95±2 | 0.72 | |
5-Fu 5+黄元5 | 25±3 | 1.41 | |
5-Fu 10+黄元10 | 67.8±2 | 0.93 | |
5-Fu 20+黄20 | 90.2±2 | 0.8 | |
5-Fu 5+黄元10 | 36.5±4 | 1.3 | |
5-Fu 10+黄元20 | 82±2 | 0.93 | |
5-Fu 20+黄元40 | 95 | 0.769 | |
5-Fu 5+黄甙5 | 22.5±2.5 | 1.5 | |
5-Fu 10+黄甙10 | 65.2±2 | 0.825 | |
5-Fu 20+黄甙20 | 87.2±3 | 0.84 | |
5-Fu 5+黄甙10 | 35.2±2 | 1.36 | |
5-Fu 10+黄甙20 | 79.8±3 | 0.877 |
5-Fu 20+黄甙40 | 95±5.7 | 0.76 |
分组 | 剂量mg/kg | 给药日程 | 体重减少率% | 瘤重(g)均值±SD, | 抑瘤率% | 动物数(只)始/末 |
对照组 | - | <0 | 2.48±0.16 | 10/10 |
5Fu | 10 | 皮下1-10 | <5 | 1.55±0.2 | 37.5 | 10/10 |
黄元 | 2.5 | 腹腔1-10 | <5 | 2.47±0.15 | 0.4 | 10/10 |
黄元 | 5 | 腹腔1-10 | <5 | 2.28±0.127 | 8 | 10/10 |
黄元 | 10 | 腹腔1-10 | <5 | 2.22±0.12 | 10.5 | 10/10 |
黄甙 | 8.25 | 腹腔1-10 | <5 | 2.32±0.09 | 6.5 | 10/10 |
黄甙 | 16.5 | 腹腔1-10 | <5 | 2.2±0.08 | 11.3 | 10/10 |
5Fu+黄元 | 10+2.5 | 1-10 | <5 | 1.32±0.09 | 46.77** | 10/10 |
5Fu+黄元 | 10+5 | 1-10 | <5 | 1.21±0.1 | 51.2** | 10/10 |
5Fu+黄元 | 10+10 | 1-10 | <5 | 0.81±0.11 | 67.3** | 10/10 |
5Fu+黄甙 | 10+8.25 | 1-10 | <5 | 1.25±0.11 | 49.6** | 10/10 |
5Fu+黄甙 | 10+16.5 | 1-10 | <5 | 1.12±0.11 | 54.8** | 10/10 |
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