CN1872136A - Medication for treating neonatal jaundice, and method of use. - Google Patents
Medication for treating neonatal jaundice, and method of use. Download PDFInfo
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- CN1872136A CN1872136A CNA2006100756160A CN200610075616A CN1872136A CN 1872136 A CN1872136 A CN 1872136A CN A2006100756160 A CNA2006100756160 A CN A2006100756160A CN 200610075616 A CN200610075616 A CN 200610075616A CN 1872136 A CN1872136 A CN 1872136A
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Abstract
An exterior-applied medicine for treating neonatal jaundice by putting the medicine in nasal cavity is prepared from the receptacle of muskmelon (10-19 Wt%), small centipeda herb (10-90), Chinese gall (0-70) and borneol (0-20).
Description
Technical field
A kind of medicine and using method thereof for the treatment of neonatal jaundice relates to the field of Chinese medicines.
Background technology
Neonatal jaundice claims hyperbilirubinemia of newborn again.Be meant that xanchromatic disease appears in neonate whole skin, mucosa and sclera.Jaundice is all more common than other any age at neonatal period.Bilirubin encephalopathy (bilirubin encephalopathy) generally only sees neonate, often causes dead and serious sequela.In general, neonatal jaundice mainly is divided into two kinds:
1, physiologic jaundice: most neonates began to occur jaundice in 2-5 days in living back, and term infant disappeared at 10 days-14 days, and the premature infant can postpone to cause disappeared in 3 week-4 weeks, though jaundice is arranged, ordinary circumstance is good.Physiologic jaundice belongs to normal physiological phenomena, need not treat.
2, pathological jaundice: arbitrary following situation all should be thought of as pathological jaundice: (in 24 hours) too early appear in jaundice; Jaundice is overweight, the jaundice of brothers' heart, and serum bilirubin is greater than 205 micromoles per liter; Jaundice is moved back and is reappeared or increase the weight of rapidly, and serum bilirubin every days such as raising greater than 85.5 micromoles per liter; Jaundice continued for a long time (term infant was longer than for 2 weeks, and the premature infant was longer than for 4 weeks); The serum conjugated bilirubin is greater than 26 micromoles per liter.
Physiologic jaundice belongs to normal physiological phenomena.Because the metabolic characteristic of neonatal bilirubin, about 60% term infant and 80% above premature infant jaundice can occur in 3-5 days after birth, but ordinary circumstance is good, and term infant jaundice in 14 days disappears, and the premature infant can be deferred to 3-4 week jaundice and all disappear.
Pathological jaundice then belongs to unusually, and is general relevant with following several factors: 1. bacterial infection and septicemia of newborn and viral infection such as hepatitis A virus (HAV), hepatitis B virus, cytomegalovirus etc.; 2. hemolytic disease of newborn; 3. congenital biliary atresia and choledochal cyst; 4. breast milk jaundice jaundice occurred in 4-7 days more than the birth back, and 2-3 week reaches the peak, and bilirubin can descend after stopping suckling 1-3 days, does not have obvious descender as 3 days and can get rid of breast milk jaundice; 5. other factors such as hereditary, drug-induced jaundice etc.
When appearring in neonate, one of following situation person should be thought of as pathological jaundice; (occurring in giving birth to back 24 hours) appears too early in jaundice; The jaundice degree is heavy or progress is fast; Jaundice longer duration (term infant surpassed for 2 weeks, and the premature infant surpassed for 4 weeks); Jaundice is moved back and reproduction person.
The pathological jaundice that any reason causes all should be found out reason and treat, the premature infant in 1 week and the infant of severe depletion of oxygen, acidosis, intracranial lesion, severe infections is arranged especially, and active treatment as early as possible is in order to avoid cause adverse consequences.
Aspect treatment, main employing is found out the cause of disease and is taked the method for corresponding treatment means to handle.General treatement:
A, breast-feed to induce and set up normal intestinal microbial population ahead of time, keep free movement of the bowels, reduce enterohepatic circulation, need not infringement be arranged and may cause hemolytic medicine liver.
B, note warmingly, supply with nutrition.
C, Light therapy are a kind of simple methods that reduces the serum unconjugated bilirubin.
Treatments such as D, employing clearing away heat-damp and promoting diuresis, blood circulation promoting and blood stasis dispelling, depressed liver-energy dispersing and function of gallbladder promoting, warming middle-JIAO and strengthening the spleen and the combination of Chinese and Western medicine, think that as Chen Ruilin the primary disease pathogenesis is damp and hot delay liver and gall, depression of liver-QI, damp and hot accumulate strongly fragrant due to, from intending baby liver soup (Herba Artemisiae Scopariae, each 10g of Herba Lysimachiae, Radix Curcumae, Radix Salviae Miltiorrhizae, Radix Isatidis, Herba Abri, each 6g of Herba Hedyotidis Diffusae, each 12g of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), Radix Glycyrrhizae 3g) treatment neonatal hepatitis syndrome 28 examples obtain good result.Wei Jun is divided into stage of icterus and convalescent period with the hepatitis syndrome, wherein jaundice due to damp-heat is controlled and is used Herba Artemisiae Scopariae Decoction, and evil malicious jaundice is controlled with Cornu rhinocerotis and loose, and the blood stasis jaundice is controlled with the red SIWU TANG of Herba Artemisiae Scopariae Decoction walnut, the wet jaundice of spleen is controlled and is used the Herba Artemisiae Scopariae lizhong decoction, convalescent period deficiency in both Qi and blood then control and use BAZHEN TANG.On dialectical basis, add and use the Western medicine antibiotic, hepatinica, total effective rate reaches 95%." Yang Shancun utilization combined therapy of Chinese and Western medicine treatment neonatal hepatitis syndrome 71 examples; noxious dampness type that treatment by Chinese herbs is insufficiency of the spleen is equipped with Poria 15g with weijing decoction (Rhizoma Phragmitis, Semen Coicis, Semen Persicae, each 10g of Semen Benincasae), Flos Lonicerae soup (Flos Lonicerae, Herba Lysimachiae, each 10g of Folium Microcoris paniculatae); Herba Artemisiae Scopariae, each 6g of Herba Hedyotidis Diffusae; Herba Abri, Herba Desmodii Triquetri (Herba Tadehagi Triquetri), each 10g of Spica Prunellae, Radix Curcumae 3g etc.; Deficiency of spleen and stomach type decoction of four noble drugs is main, is equipped with Fructus Setariae Germinatus 15g, Herba Artemisiae Scopariae, Cortex Moutan, Flos Lonicerae, Radix Salviae Miltiorrhizae, each 6g of Radix Paeoniae Rubra, Jilin ginseng, each 3g of Fructus Schisandrae Chinensis, Radix Notoginseng 1S, the Radix Polygoni Multiflori, each 10g of Testa sojae atricolor etc.The result cures 15 examples, 44 examples that take a turn for the better, 8 examples that do not heal, dead 4 examples.Herba Artemisiae Scopariae Tonga flavor (Herba Artemisiae Scopariae 12～15g such as Shi Yumin, Fructus Gardeniae, each 9g of Herba Plantaginis, Herba Lysimachiae 15-30g, Herba Polygoni Avicularis 15g, Radix et Rhizoma Rhei (processed) 3-4.5g, Radix Glycyrrhizae 3g) be basic side's treatment neonatal hepatitis syndrome 19 examples, contrast with 16 examples of hormone therapy, Chinese drug-treated group is cured 15 examples as a result, 3 examples that take a turn for the better, invalid 1 example; The hormone group is cured 8 examples, 5 examples that take a turn for the better, and invalid 3 examples, and the Chinese drug-treated group jaundice eliminating is very fast.Follow up a case by regular visits to through long term for two groups, body weight index Chinese drug-treated group is better, and two groups of all the other development indexs are similar.Shi Shi also finds under study for action, uses rhubarb tablets treatment INFANT HEPATITIS SYNDROME, the regression time of jaundice and clinical efficacy and Cholagogue Mixture (Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei, SHANZHIZI, Radix Paeoniae Rubra, Radix Scutellariae, Poria) comparison there are no significant difference.Experimentation shows that still rhubarb tablets is to isothiocyanic acid.The serum bilirubin of naphthalene ester (ANIT) jaundice animal model and SGPT raise inhibitory action, and the effect that promotes bile secretion is arranged.
Reports such as hyperbilirubinemia He Fang are treated neonatal jaundice 60 examples with the gallbladder jaundice eliminating oral liquid (Herba Artemisiae Scopariae, Fructus Gardeniae, Cortex Phellodendri, Cortex Magnoliae Officinalis, Radix Arnebiae (Radix Lithospermi), Indigo Naturalis, Herba Lycopi, Radix Rubiae, artificial Calculus Bovis) that disappears; total effective rate reaches 80%, and it is short than SANHUANG mixture (Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Fructus Gardeniae) group that serum bilirubin drops to normal required time.In relevant pharmacodynamic study, prove all that from five aspects such as function of gallbladder promoting, protection erythrocyte membrane, immunology observation, liver injury protection and antiinflammatory actions it has obvious effect.Shi Lanying is reported in and adds on the basis of doctor trained in Western medicine conventional therapy with Chinese medicine Herba Artemisiae Scopariae, Fructus Forsythiae, Fructus Gardeniae, Radix Paeoniae Rubra, Poria, Flos Lonicerae, Cortex Phellodendri, Rhizoma Imperatae, Radix Et Rhizoma Rhei treatment hyperbilirubinemia of newborn, and is evident in efficacy.
The treatment that need exchange blood transfusion of E, intravenous applications albumin, severe patient.
These Therapeutic Method have certain effect in the prior art, but also exist the conservative safety of three kinds of methods of drawback: ABC separately, without any side effect, still, just because of it is conservative, might cause the delay of the state of an illness; It is very limited for the ability to accept of medicine that neonatal internal organs do not have zoon, and the method through port preparation for treating neonatal jaundice that takes traditional Chinese medicine of the utilization combination of Chinese and Western medicine also exists certain insecurity; As for the intravenous applications albumin, the method that severe patient need exchange blood transfusion and treat, risk is big especially.
Summary of the invention
An object of the present invention is to solving above-mentioned prior art at risk height aspect the treatment neonatal jaundice, the problem that side effect is big, provide a kind of safe, treat the medicine of neonatal jaundice efficiently.
An object of the present invention is to provide a kind of using method for the treatment of the medicine of neonatal jaundice.
For achieving the above object, a technical scheme of the present invention provides a kind of medicine for the treatment of neonatal jaundice, is mainly made by following weight percentages: muskmelon pedicel 10-90%, Herba Centipedae 10-90%.
A kind of optimization formula for the treatment of the medicine of neonatal jaundice of the present invention is: made by following weight percentages: muskmelon pedicel 40-85%, Herba Centipedae 15-60%.
A kind of medicine for the treatment of neonatal jaundice also comprises following weight percentages: Galla Chinensis 0-70%.
A kind of medicine for the treatment of neonatal jaundice also comprises following weight percentages: Borneolum Syntheticum 0-20%.
A kind of medicine optimization formula for the treatment of neonatal jaundice is: made by following weight percentages: muskmelon pedicel 50-80%, Herba Centipedae 18-35%, Galla Chinensis 5-20%
A kind of medicine optimization formula for the treatment of neonatal jaundice is: made by following weight percentages: muskmelon pedicel 55-75%, Herba Centipedae 20-30%, Galla Chinensis 10-15%, Borneolum Syntheticum 1-5%.
A kind of medicine optimization formula for the treatment of neonatal jaundice is: made by following weight percentages: muskmelon pedicel 60%, Herba Centipedae 25%, Galla Chinensis 12%, Borneolum Syntheticum 3%.
Another technical scheme of the present invention provides a kind of using method for the treatment of the medicine of neonatal jaundice, and this method is that the medicine of treatment neonatal jaundice is inserted in the infant nasal cavity.
More particularly, the medicine of treatment neonatal jaundice is made the nose bolt: medicine is made fine powder below 150 orders, spray or be dispersed in nose bolt surface, or, medicine is made fine powder below 150 orders, spray or be dispersed on fabric or the softish carrier, fabric or carrier are wrapped on the nose bolt carrier of prior art, make medicinal nose bolt; During use the nose bolt is placed the infant nasal cavity.
More particularly, the medicine of treatment neonatal jaundice is made the nose bolt: medicine is made nano level fine powder, spray or be dispersed in nose bolt surface, or, medicine is made nano level fine powder, spray or be dispersed on fabric or the softish carrier, fabric or carrier are wrapped on the nose bolt carrier of prior art, make medicinal nose bolt; During use the nose bolt is placed the infant nasal cavity.
Described carrier is a carrier of the prior art, as sponge, foam, paper, thin film, Cotton Gossypii etc.
Described fabric is a fabric of the prior art, as gauze, cotton, non-woven fabrics etc.
Muskmelon pedicel: for Fructus Melo has the carpopodium of part peel, name has another name called Pedicellus Melo.Nature and flavor: bitter cold.Gui Jing: positive bright stomach is told medicine.Function: can tell the wind heat sputum, the postcibal vomiting dyspepsia.Cure mainly: (1) controls dizziness due to wind pathogen headache, regretful sleeplessness, insane sore throat.(2) head's dampness, edema jaundice, damp and hot all diseases.
Herba Centipedae: be the dry herb of feverfew Herba Centipedae.Meridian distribution of property and flavor: suffering, temperature.Return lung, Liver Channel.Character identification: this product is tangled agglomerating.Fibrous root is very thin, and is faint yellow.Stem is thin, multi-branched; Matter is crisp, frangibility, section yellow-white.Leaf is little, nearly stockless; The many shrinkages of blade, fragmentation, complete person is cochlear after flattening, surperficial celadon or sepia, there is 3-5 sawtooth at the edge.Head inflorescence yellow or yellowish-brown.Function cures mainly: clearing the nasal passage, and cough-relieving is used for headche due to wind-cold, cough with copious phlegm, it is obstructed to have a stuffy nose, the nasal sinusitis watery nasal discharge.
Galla Chinensis has another name called gall nut, Conch Meretricis seu Cyclinae, insect gall, hundred worm storehouses, Mass Galla chinesis et camelliae Fermentata etc.Be that times Aphidiadae insecticide Chinese Nut-gall aphid or melaphis peitan Tsai et Tang parasitize the insect gall that trees such as Anacardiaceae, Rhus plant Fructus rhois chinensis, blue or green bran poplar, Radix Rhois Sinicae upward form.The Galla Chinensis sour in the mouth becomes, and property is flat.Tool is astringed the lung, the effect of astringing intestine to stop diarrhea, hemostasis, hidroschesis, controlling nocturnal emission with astringent drugs.Cure mainly chronic cough, chronic diarrhea, chronic dysentery, have blood in stool, proctoptosis, metrorrhagia, edema, spontaneous perspiration, night sweat, five hemorrhoid, seminal emission, spermatorrhea, scabies, furuncle etc.Multiple diseases such as wound hemorrhage, ulcer being unable to heal are controlled in external.
Borneolum Syntheticum: have another name called: Borneolum Syntheticum, borneol, Borneolum Syntheticum, sheet brain, etc., be the processed goods of Dipterocarpaceae plant Borneolum Syntheticum resin, or for Camphora, Lignum Pini Nodi wet goods with the synthetic product of being processed into of chemical method; Nature and flavor: arduous, cold.Function cures mainly: logical all keys, the stagnated fire of loosing, removing nebula make eye bright, reducing swelling and alleviating pain.
Beneficial effect
Beneficial effect of the present invention is:
1. what adopt is a kind of external used medicine safely and efficiently, has avoided the injury of medicine to the neonate internal organs of fragility.
2. this product medication is simple, is guidance with motherland's theory of medicine, by cooperatively interacting between the medicine, played good effect, on probation through routine infant surplus 1000, effective percentage reaches 99.9%, nasal cavity applied medicine once promptly the recovery from illness, more than 80% within the week bilirubin promptly return to normal range.
Model case:
Case one:
Wang Mengjia, woman, 36 days
Symptom: the infant whole skin presents, and laboratory examination, total bilirubin 513 are arranged like the Fructus Citri tangerinae yellow.
Medicine for treatment: the about 0.1g of medicine of the present invention includes nasal cavity in.
Therapeutic effect: medication is once fully recovered, and is normal after the week.
Follow up a case by regular visits to after controlling: follow up a case by regular visits to after 3 months, recurrence is not arranged; Sign is grown each systems inspection, and all belong to normal range.
Case two:
Wang Zhilong, man 60 days,
Symptom: infant was not healed laboratory examination, total bilirubin 299 in 2 months from the birth yellowing of the skin.
Medicine for treatment: the side uses: the about 0.1g of face places and includes nasal cavity on the cotton balls in.
Therapeutic effect: nasal cavity applied medicine is once fully recovered, and chemical examination is normal after the week.
Follow up a case by regular visits to after the smelting: followed up a case by regular visits to 2 years 0 10 months, and do not recur. have no adverse reaction.
Case three:
Zhang Yaze, 20 days,
Symptom: whole skin is yellow as Fructus Citri tangerinae. laboratory examination, total bilirubin 368.
Medicine for treatment: the side uses: the about 0.1g of face, make the nose bolt and include nasal cavity in.
Therapeutic effect: chemical examination total bilirubin normal range after nasal cavity applied medicine was once fully recovered 10 days.
Follow up a case by regular visits to after controlling: follow up a case by regular visits to 39 months the chemical examination total bilirubin normal, have no adverse reaction.
3. a kind of medicine manufacture method for the treatment of neonatal jaundice of the present invention is simple, is fit to suitability for industrialized production; Easy to use, can not cause suffering to infant.
4. be a kind of fairly simple, method that side effect is low with blue streak therapy for treating neonatal jaundice in the prior art, compare with medicine of the present invention, because the needed medical treatment of blue streak therapy is complicated, treatment cost height, effect is also good not as the present invention; Medicine of the present invention is easier, safe, efficient aspect treatment neonatal jaundice.
The specific embodiment
Further specify the present invention below in conjunction with embodiment, but these embodiment are not as a limitation of the invention.
Embodiment 1
Get muskmelon pedicel 0.68g, Herba Centipedae 0.2g, Galla Chinensis 0.1g, Borneolum Syntheticum 0.02g grinds the powder that can cross 200 mesh sieves, powder is sprayed on the commercially available disposable multipurpose nose bolt get final product.
Embodiment 2
Muskmelon pedicel 80kg, Herba Centipedae 20kg pulverizes, and grinds into nano level fine powder with colloid mill, is sprayed on the non-woven fabrics, non-woven fabrics is wrapped on the nose bolt carrier of prior art, makes medicinal nose inspection.
Embodiment 3-18
Produce a kind of medicine for the treatment of neonatal jaundice according to embodiment 1 described method, raw materials used as shown in the table:
| Raw material (kg) | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 | Embodiment 7 | Embodiment 8 | Embodiment 9 | Embodiment 10 |
| Muskmelon pedicel | 10 | 90 | 85 | 20 | 60 | 40 | 20 | 55 |
| Herba Centipedae | 90 | 10 | 15 | 10 | 20 | 60 | 40 | 25 |
| Galla Chinensis | 0 | 0 | 0 | 70 | 0 | 0 | 20 | 10 |
| Borneolum Syntheticum | 0 | 0 | 0 | 0 | 20 | 0 | 20 | 10 |
| Raw material (kg) | Embodiment 11 | Embodiment 12 | Embodiment 13 | Embodiment 14 | Embodiment 15 | Embodiment 16 | Embodiment 17 | Embodiment 18 |
| Muskmelon pedicel | 80 | 55 | 75 | 59 | 70 | 40 | 73 | 70 |
| Herba Centipedae | 20 | 35 | 18 | 30 | 13 | 10 | 10 | 15 |
| Galla Chinensis | 0 | 8 | 7 | 10 | 12 | 46 | 15 | 12 |
| Borneolum Syntheticum | 0 | 2 | 0 | 1 | 5 | 4 | 2 | 3 |
Claims (10)
1. a medicine for the treatment of neonatal jaundice is characterized in that, is mainly made by following weight percentages: muskmelon pedicel 10-90%, Herba Centipedae 10-90%.
2. according to the medicine of the described treatment neonatal jaundice of claim 1, it is characterized in that, mainly make: muskmelon pedicel 40-85%, Herba Centipedae 15-60% by following weight percentages.
3. according to the medicine of the described treatment neonatal jaundice of claim 1, it is characterized in that, also comprise following weight percentages: Galla Chinensis 0-70%.
4. according to the medicine of the described treatment neonatal jaundice of claim 1, it is characterized in that, also comprise following weight percentages: Borneolum Syntheticum 0-20%.
5. according to the medicine of the arbitrary described treatment neonatal jaundice of claim 1-4, it is characterized in that, make: muskmelon pedicel 50-80%, Herba Centipedae 18-35%, Galla Chinensis 5-20% by following weight percentages.
6. according to the medicine of the arbitrary described treatment neonatal jaundice of claim 1-4, it is characterized in that, make: muskmelon pedicel 55-75%, Herba Centipedae 20-30%, Galla Chinensis 10-15%, Borneolum Syntheticum 1-5% by following weight percentages.
7. according to the medicine of the described treatment neonatal jaundice of claim 4, it is characterized in that, make: muskmelon pedicel 60%, Herba Centipedae 25%, Galla Chinensis 12%, Borneolum Syntheticum 3% by following weight percentages.
8. according to the using method of the medicine of the described treatment neonatal jaundice of claim 1: the medicine that will treat neonatal jaundice is inserted in the infant nasal cavity.
9. the using method of the medicine of described according to Claim 8 treatment neonatal jaundice: medicine is made fine powder below 150 orders, spray or be dispersed in nose bolt surface, or, medicine is made fine powder below 150 orders, spray or be dispersed on fabric or the softish carrier, fabric or carrier are wrapped on the nose bolt carrier of prior art, make medicinal nose bolt.
10. the using method of the medicine of described according to Claim 8 treatment neonatal jaundice: medicine is made nano level fine powder, spray or be dispersed in nose bolt surface, or, medicine is made nano level fine powder, spray or be dispersed on fabric or the softish carrier, fabric or carrier are wrapped on the nose bolt carrier of prior art, make medicinal nose bolt.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2006100756160A CN100413513C (en) | 2006-04-17 | 2006-04-17 | Medication for treating neonatal jaundice, and method of use. |
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| CNB2006100756160A CN100413513C (en) | 2006-04-17 | 2006-04-17 | Medication for treating neonatal jaundice, and method of use. |
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| CN1872136A true CN1872136A (en) | 2006-12-06 |
| CN100413513C CN100413513C (en) | 2008-08-27 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107875317A (en) * | 2017-12-26 | 2018-04-06 | 广西壮要方医院有限公司 | A kind of medicine for treating jaundice |
| CN109504790A (en) * | 2019-01-15 | 2019-03-22 | 上海交通大学医学院附属上海儿童医学中心 | Evaluate biomarker, kit and the method for breast milk jaundice |
| CN112802597A (en) * | 2021-01-18 | 2021-05-14 | 吾征智能技术(北京)有限公司 | Intelligent neonatal jaundice evaluation system, device and storage medium |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1164284C (en) * | 2001-03-23 | 2004-09-01 | 刘渭滨 | Medicine for treating neonatal jaundice |
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2006
- 2006-04-17 CN CNB2006100756160A patent/CN100413513C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107875317A (en) * | 2017-12-26 | 2018-04-06 | 广西壮要方医院有限公司 | A kind of medicine for treating jaundice |
| CN109504790A (en) * | 2019-01-15 | 2019-03-22 | 上海交通大学医学院附属上海儿童医学中心 | Evaluate biomarker, kit and the method for breast milk jaundice |
| CN112802597A (en) * | 2021-01-18 | 2021-05-14 | 吾征智能技术(北京)有限公司 | Intelligent neonatal jaundice evaluation system, device and storage medium |
| CN112802597B (en) * | 2021-01-18 | 2023-11-21 | 吾征智能技术(北京)有限公司 | Intelligent evaluation system, equipment and storage medium for neonatal jaundice |
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