CN1864068B - 用小表位抗体降低样品复杂度的方法 - Google Patents

用小表位抗体降低样品复杂度的方法 Download PDF

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Publication number
CN1864068B
CN1864068B CN2004800295981A CN200480029598A CN1864068B CN 1864068 B CN1864068 B CN 1864068B CN 2004800295981 A CN2004800295981 A CN 2004800295981A CN 200480029598 A CN200480029598 A CN 200480029598A CN 1864068 B CN1864068 B CN 1864068B
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China
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protein
small epitope
epitope antibodies
sample
antibody
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Expired - Fee Related
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CN2004800295981A
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English (en)
Chinese (zh)
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CN1864068A (zh
Inventor
M·S·乌尔代亚
G·M·兰德斯
G·T·文特
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Tethys Bioscience Inc
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Tethys Bioscience Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN2004800295981A 2003-08-18 2004-08-18 用小表位抗体降低样品复杂度的方法 Expired - Fee Related CN1864068B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US49615403P 2003-08-18 2003-08-18
US60/496,154 2003-08-18
US51172003P 2003-10-15 2003-10-15
US60/511,720 2003-10-15
PCT/US2004/027005 WO2005019831A2 (en) 2003-08-18 2004-08-18 Methods for reducing complexity of a sample using small epitope antibodies

Publications (2)

Publication Number Publication Date
CN1864068A CN1864068A (zh) 2006-11-15
CN1864068B true CN1864068B (zh) 2010-10-13

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CN2004800295981A Expired - Fee Related CN1864068B (zh) 2003-08-18 2004-08-18 用小表位抗体降低样品复杂度的方法

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US (3) US20050131219A1 (enExample)
EP (1) EP1658506A2 (enExample)
JP (1) JP2007502837A (enExample)
CN (1) CN1864068B (enExample)
AU (1) AU2004267802B2 (enExample)
CA (1) CA2536062A1 (enExample)
WO (1) WO2005019831A2 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2502246A1 (en) * 2002-10-15 2004-04-29 Abmetrix, Inc. Sets of digital antibodies directed against short epitopes, and methods using same
WO2005019831A2 (en) * 2003-08-18 2005-03-03 Tethys Bioscience, Inc. Methods for reducing complexity of a sample using small epitope antibodies
CA2596518A1 (en) * 2005-01-31 2006-08-10 Insilicos, Llc Methods of identification of biomarkers with mass spectrometry techniques
US7763423B2 (en) * 2005-09-30 2010-07-27 Pacific Biosciences Of California, Inc. Substrates having low density reactive groups for monitoring enzyme activity
US8097425B2 (en) 2006-03-10 2012-01-17 Tethys Bioscience, Inc. Multiplex protein fractionation
US20080050747A1 (en) * 2006-03-30 2008-02-28 Pacific Biosciences Of California, Inc. Articles having localized molecules disposed thereon and methods of producing and using same
US8975216B2 (en) * 2006-03-30 2015-03-10 Pacific Biosciences Of California Articles having localized molecules disposed thereon and methods of producing same
WO2007117444A2 (en) * 2006-03-31 2007-10-18 Yinghe Hu Protein detection by aptamers
DE102006015001A1 (de) * 2006-03-31 2007-10-11 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen Verfahren zum Nachweis und/oder zur Anreicherung von Analytproteinen und/oder Analytpeptiden aus einer komplexen Proteinmischung
US20080280778A1 (en) * 2007-05-03 2008-11-13 Urdea Michael S Binding reagents that contain small epitope binding molecules
WO2010047797A2 (en) * 2008-10-21 2010-04-29 Research Foundation Of The City University Of New York Single quantum-dot-based aptameric sensors
US9202678B2 (en) * 2008-11-14 2015-12-01 Board Of Trustees Of Michigan State University Ultrafast laser system for biological mass spectrometry
US8501406B1 (en) 2009-07-14 2013-08-06 Pacific Biosciences Of California, Inc. Selectively functionalized arrays
KR20130084091A (ko) 2012-01-16 2013-07-24 삼성전자주식회사 화상형성장치
WO2023200284A1 (ko) * 2022-04-15 2023-10-19 재단법인대구경북과학기술원 생체 시료 내 지질 연관 단백질의 질량 분석을 위한 지질 연관 단백질의 정제 및 농축 방법

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001086306A2 (en) * 2000-05-05 2001-11-15 Purdue Research Foundation Affinity selected signature peptides for protein identification and quantification
WO2003027682A2 (en) * 2001-09-27 2003-04-03 Purdue Research Foundation Controlling isotope effects during fractionation of analytes
US20030119063A1 (en) * 2002-09-03 2003-06-26 Pham Thang T. High accuracy protein identification

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5807715A (en) * 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US4774339A (en) * 1987-08-10 1988-09-27 Molecular Probes, Inc. Chemically reactive dipyrrometheneboron difluoride dyes
US5217869A (en) * 1987-10-13 1993-06-08 Terrapin Technologies, Inc. Method to produce immunodiagnostic reagents
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5427908A (en) * 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
US5168499A (en) * 1990-05-02 1992-12-01 California Institute Of Technology Fault detection and bypass in a sequence information signal processor
WO1994004679A1 (en) * 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
GB9115364D0 (en) * 1991-07-16 1991-08-28 Wellcome Found Antibody
AU669124B2 (en) * 1991-09-18 1996-05-30 Kyowa Hakko Kirin Co., Ltd. Process for producing humanized chimera antibody
ES2136092T3 (es) * 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
US5714350A (en) * 1992-03-09 1998-02-03 Protein Design Labs, Inc. Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
US5733743A (en) * 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
US6210671B1 (en) * 1992-12-01 2001-04-03 Protein Design Labs, Inc. Humanized antibodies reactive with L-selectin
US6180377B1 (en) * 1993-06-16 2001-01-30 Celltech Therapeutics Limited Humanized antibodies
JPH0793370A (ja) * 1993-09-27 1995-04-07 Hitachi Device Eng Co Ltd 遺伝子データベース検索システム
US6017693A (en) * 1994-03-14 2000-01-25 University Of Washington Identification of nucleotides, amino acids, or carbohydrates by mass spectrometry
US5701256A (en) * 1995-05-31 1997-12-23 Cold Spring Harbor Laboratory Method and apparatus for biological sequence comparison
US6265150B1 (en) * 1995-06-07 2001-07-24 Becton Dickinson & Company Phage antibodies
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
US6410245B1 (en) * 1998-04-01 2002-06-25 Affymax, Inc. Compositions and methods for detecting ligand-dependent nuclear receptor and coactivator interactions
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6441140B1 (en) * 1998-09-04 2002-08-27 Cell Signaling Technology, Inc. Production of motif-specific and context-independent antibodies using peptide libraries as antigens
US7198896B2 (en) * 1998-09-04 2007-04-03 Cell Signaling Technology, Inc. Immunoaffinity isolation of modified peptides from complex mixtures
DE60042738D1 (de) * 1999-05-07 2009-09-24 Life Technologies Corp Verfahren zum nachweis von analyten mit hilfe von halbleiternanokrystallen
US20020015952A1 (en) * 1999-07-30 2002-02-07 Anderson Norman G. Microarrays and their manufacture by slicing
US7351540B1 (en) * 2000-03-17 2008-04-01 Merck Patent Gmbh Protein isolation and analysis
AU2001283562B2 (en) * 2000-08-11 2006-10-26 Perkin-Elmer Las, Inc. Ultra-sensitive detection systems
GB0022978D0 (en) * 2000-09-19 2000-11-01 Oxford Glycosciences Uk Ltd Detection of peptides
JP2002191364A (ja) * 2000-12-26 2002-07-09 Mitsubishi Chemicals Corp タンパク質の検出あるいは定量方法
AU2002245368A2 (en) * 2001-02-01 2002-08-12 Ciphergen Biosystems, Inc. Improved methods for protein identification, characterization and sequencing by tandem mass spectrometry
US20030219734A1 (en) * 2001-04-13 2003-11-27 Biosite Incorporated Polypeptides related to natriuretic peptides and methods of their identification and use
US20040010376A1 (en) * 2001-04-17 2004-01-15 Peizhi Luo Generation and selection of protein library in silico
US7117096B2 (en) * 2001-04-17 2006-10-03 Abmaxis, Inc. Structure-based selection and affinity maturation of antibody library
US20030022240A1 (en) * 2001-04-17 2003-01-30 Peizhi Luo Generation and affinity maturation of antibody library in silico
US6833441B2 (en) * 2001-08-01 2004-12-21 Abmaxis, Inc. Compositions and methods for generating chimeric heteromultimers
US7175983B2 (en) * 2001-11-02 2007-02-13 Abmaxis, Inc. Adapter-directed display systems
US7473535B2 (en) * 2002-08-20 2009-01-06 The Institute For Systems Biology Chemical reagents and methods for detection and quantification of proteins in complex mixtures
CA2502246A1 (en) * 2002-10-15 2004-04-29 Abmetrix, Inc. Sets of digital antibodies directed against short epitopes, and methods using same
WO2005019831A2 (en) * 2003-08-18 2005-03-03 Tethys Bioscience, Inc. Methods for reducing complexity of a sample using small epitope antibodies

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001086306A2 (en) * 2000-05-05 2001-11-15 Purdue Research Foundation Affinity selected signature peptides for protein identification and quantification
WO2003027682A2 (en) * 2001-09-27 2003-04-03 Purdue Research Foundation Controlling isotope effects during fractionation of analytes
US20030119063A1 (en) * 2002-09-03 2003-06-26 Pham Thang T. High accuracy protein identification

Also Published As

Publication number Publication date
US20050131219A1 (en) 2005-06-16
WO2005019831A2 (en) 2005-03-03
AU2004267802B2 (en) 2011-03-17
CN1864068A (zh) 2006-11-15
EP1658506A2 (en) 2006-05-24
WO2005019831A3 (en) 2005-08-25
US20080241934A1 (en) 2008-10-02
AU2004267802A1 (en) 2005-03-03
CA2536062A1 (en) 2005-03-03
US20070042431A1 (en) 2007-02-22
WO2005019831B1 (en) 2005-11-03
JP2007502837A (ja) 2007-02-15

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Termination date: 20120818