CN1863560A - 用于促进止血的血纤蛋白原靶向微粒 - Google Patents

用于促进止血的血纤蛋白原靶向微粒 Download PDF

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Publication number
CN1863560A
CN1863560A CNA200480029425XA CN200480029425A CN1863560A CN 1863560 A CN1863560 A CN 1863560A CN A200480029425X A CNA200480029425X A CN A200480029425XA CN 200480029425 A CN200480029425 A CN 200480029425A CN 1863560 A CN1863560 A CN 1863560A
Authority
CN
China
Prior art keywords
fibrinogen
product
platelet
peptide
platelets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA200480029425XA
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English (en)
Chinese (zh)
Inventor
A·H·古道尔
S·M·泰勒
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Haemostatix Ltd
Original Assignee
Haemostatix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Haemostatix Ltd filed Critical Haemostatix Ltd
Publication of CN1863560A publication Critical patent/CN1863560A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CNA200480029425XA 2003-10-07 2004-10-07 用于促进止血的血纤蛋白原靶向微粒 Pending CN1863560A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0323378.0A GB0323378D0 (en) 2003-10-07 2003-10-07 Therapeutic agent
GB0323378.0 2003-10-07

Publications (1)

Publication Number Publication Date
CN1863560A true CN1863560A (zh) 2006-11-15

Family

ID=29415609

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA200480029425XA Pending CN1863560A (zh) 2003-10-07 2004-10-07 用于促进止血的血纤蛋白原靶向微粒

Country Status (9)

Country Link
US (1) US20080064628A1 (enExample)
EP (1) EP1677829B1 (enExample)
JP (2) JP4938454B2 (enExample)
CN (1) CN1863560A (enExample)
AU (1) AU2004280115B2 (enExample)
CA (1) CA2541005C (enExample)
GB (1) GB0323378D0 (enExample)
IL (1) IL174580A0 (enExample)
WO (1) WO2005035002A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101687061B (zh) * 2006-11-27 2013-03-27 哈莫斯塔蒂斯有限公司 生物凝胶
CN107592814A (zh) * 2015-05-11 2018-01-16 哈莫斯塔蒂斯有限公司 止血组合物
CN110448719A (zh) * 2019-06-28 2019-11-15 浙江大学 一种促进凝血的丝素-多肽电纺膜及其制备方法

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0516091D0 (en) * 2005-08-04 2005-09-14 Haemostatix Ltd Therapeutic agent
US9114127B2 (en) * 2007-05-15 2015-08-25 Richard C. K. Yen Biologic devices for hemostasis
US20100204107A1 (en) * 2007-09-11 2010-08-12 Dorian Bevec Use of urodilatin as a therapeutic agent
KR20100057061A (ko) * 2007-09-11 2010-05-28 몬도바이오테크 래보래토리즈 아게 치료제로서의 펩티드 ｍａｉｐｐｋｋｎｑｄｋ （소 카파 카세인 １０６－１１６）및／또는 ｙｇｆｑｎａ （세로르핀）의 용도
GB201101740D0 (en) * 2011-02-01 2011-03-16 Haemostatix Ltd Therapeutic agents with improved fibrinogen binding
GB201201751D0 (en) * 2012-02-01 2012-03-14 Haemostatix Ltd Haemostatic wound dressing
GB201204868D0 (en) 2012-03-20 2012-05-02 San Raffaele Centro Fond Peptides
AU2013334180A1 (en) * 2012-10-25 2015-05-14 The Children's Hospital Of Philadelphia Affinity peptide-modified particles and targeted drug delivery methods
WO2017103914A1 (en) * 2015-12-17 2017-06-22 Regentis Biomaterials Ltd. Ready for use organic solvent free compositions comprising protein-polymer conjugates and uses thereof
EP3887404A4 (en) 2018-11-30 2022-11-02 Cellphire, Inc. SLIDES LOADED WITH ANTI-CANCER AGENTS
US11767511B2 (en) 2018-11-30 2023-09-26 Cellphire, Inc. Platelets as delivery agents
CA3138529C (en) 2019-05-03 2025-10-07 Cellphire, Inc. MATERIALS AND PROCESSES FOR THE PRODUCTION OF BLOOD PRODUCTS
WO2021034719A1 (en) 2019-08-16 2021-02-25 Cellphire, Inc. Thrombosomes as an antiplatelet agent reversal agent
CA3170196A1 (en) 2020-02-04 2021-08-12 Cellphire, Inc. Anti-fibrinolytic loaded platelets
TW202245814A (zh) 2021-02-17 2022-12-01 美商賽菲爾公司 用於治療抗血小板誘導的凝血病之凍乾血小板衍生物組成物
EP4416167A4 (en) * 2021-10-15 2025-11-19 Univ North Carolina State COMPOSITIONS AND PROCESSES FOR PURIFYING BIOLOGICAL FLUIDS
US12702682B2 (en) 2021-11-04 2026-08-11 Cellphire, Inc. Platelet derivative compositions, and methods of making and using such compositions
GB2642384A (en) * 2023-01-31 2026-01-07 Univ North Carolina State Compositions and methods for purifying biological fluids

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5357042A (en) * 1984-04-23 1994-10-18 The General Hospital Corporation Synthetic peptides capable of eliciting fibrin-specific monoclonal antibodies lacking fibrinogen-cross-reactivity
US6391343B1 (en) * 1991-01-15 2002-05-21 Hemosphere, Inc. Fibrinogen-coated particles for therapeutic use
DE4310632A1 (de) 1993-04-01 1994-10-06 Merck Patent Gmbh Lineare Adhäsionsinhibitoren
DE69529917T2 (de) * 1994-12-16 2003-12-11 Elan Drug Delivery Ltd., Ruddington Vernetzte mikropartikel und ihre verwendung als arzneiträger
AU718956B2 (en) * 1996-10-21 2000-05-04 Quadrant Healthcare (Uk) Limited Platelet substitutes and conjugation methods suitable for their preparation
GB9724143D0 (en) 1997-11-14 1998-01-14 Andaris Ltd Pharmaceutical conjugate
US20030021777A1 (en) * 1998-02-20 2003-01-30 Roy Harris Product comprising bound fibrinogen and thrombin for use in wound therapy or surgical repair
US20040127416A1 (en) 2002-11-15 2004-07-01 Massia Stephen P. Therapeutic bioconjugates

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101687061B (zh) * 2006-11-27 2013-03-27 哈莫斯塔蒂斯有限公司 生物凝胶
US9339584B2 (en) 2006-11-27 2016-05-17 Haemostatix Limited Biogel
US9913876B2 (en) 2006-11-27 2018-03-13 Haemostatix Limited Biogel
CN107592814A (zh) * 2015-05-11 2018-01-16 哈莫斯塔蒂斯有限公司 止血组合物
CN110448719A (zh) * 2019-06-28 2019-11-15 浙江大学 一种促进凝血的丝素-多肽电纺膜及其制备方法

Also Published As

Publication number Publication date
EP1677829A1 (en) 2006-07-12
JP2011184465A (ja) 2011-09-22
IL174580A0 (en) 2006-08-20
AU2004280115A1 (en) 2005-04-21
AU2004280115B2 (en) 2011-03-24
GB0323378D0 (en) 2003-11-05
JP4938454B2 (ja) 2012-05-23
CA2541005A1 (en) 2005-04-21
EP1677829B1 (en) 2014-12-24
WO2005035002A1 (en) 2005-04-21
CA2541005C (en) 2012-05-08
JP2007507480A (ja) 2007-03-29
US20080064628A1 (en) 2008-03-13

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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Open date: 20061115