JP4938454B2 - 止血を促進するためのフィブリノゲン標的微粒子 - Google Patents
止血を促進するためのフィブリノゲン標的微粒子 Download PDFInfo
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- JP4938454B2 JP4938454B2 JP2006530592A JP2006530592A JP4938454B2 JP 4938454 B2 JP4938454 B2 JP 4938454B2 JP 2006530592 A JP2006530592 A JP 2006530592A JP 2006530592 A JP2006530592 A JP 2006530592A JP 4938454 B2 JP4938454 B2 JP 4938454B2
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- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 229960003766 thrombin (human) Drugs 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| GB0323378.0 | 2003-10-07 | ||
| GBGB0323378.0A GB0323378D0 (en) | 2003-10-07 | 2003-10-07 | Therapeutic agent |
| PCT/GB2004/004235 WO2005035002A1 (en) | 2003-10-07 | 2004-10-07 | Fibrinogen targetting microparticles for promoting haemostasie |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2011143587A Division JP2011184465A (ja) | 2003-10-07 | 2011-06-28 | 止血を促進するためのフィブリノゲン標的微粒子 |
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| JP2007507480A JP2007507480A (ja) | 2007-03-29 |
| JP2007507480A5 JP2007507480A5 (enExample) | 2007-11-22 |
| JP4938454B2 true JP4938454B2 (ja) | 2012-05-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2006530592A Expired - Fee Related JP4938454B2 (ja) | 2003-10-07 | 2004-10-07 | 止血を促進するためのフィブリノゲン標的微粒子 |
| JP2011143587A Withdrawn JP2011184465A (ja) | 2003-10-07 | 2011-06-28 | 止血を促進するためのフィブリノゲン標的微粒子 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2011143587A Withdrawn JP2011184465A (ja) | 2003-10-07 | 2011-06-28 | 止血を促進するためのフィブリノゲン標的微粒子 |
Country Status (9)
| Country | Link |
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| US (1) | US20080064628A1 (enExample) |
| EP (1) | EP1677829B1 (enExample) |
| JP (2) | JP4938454B2 (enExample) |
| CN (1) | CN1863560A (enExample) |
| AU (1) | AU2004280115B2 (enExample) |
| CA (1) | CA2541005C (enExample) |
| GB (1) | GB0323378D0 (enExample) |
| IL (1) | IL174580A0 (enExample) |
| WO (1) | WO2005035002A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
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| GB0516091D0 (en) | 2005-08-04 | 2005-09-14 | Haemostatix Ltd | Therapeutic agent |
| GB0623607D0 (en) | 2006-11-27 | 2007-01-03 | Haemostatix Ltd | Tissue adhesive |
| US9114127B2 (en) * | 2007-05-15 | 2015-08-25 | Richard C. K. Yen | Biologic devices for hemostasis |
| KR20100057641A (ko) * | 2007-09-11 | 2010-05-31 | 몬도바이오테크 래보래토리즈 아게 | 인터메딘 ４７ 및 ５３ 펩티드의 치료적 용도 |
| KR20100061487A (ko) * | 2007-09-11 | 2010-06-07 | 몬도바이오테크 래보래토리즈 아게 | 펩티드 ｙｇｌｆ 및 ｋｖｌｐｖｐｑ와의 배합물의 치료적 용도 |
| GB201101740D0 (en) * | 2011-02-01 | 2011-03-16 | Haemostatix Ltd | Therapeutic agents with improved fibrinogen binding |
| GB201201751D0 (en) * | 2012-02-01 | 2012-03-14 | Haemostatix Ltd | Haemostatic wound dressing |
| GB201204868D0 (en) | 2012-03-20 | 2012-05-02 | San Raffaele Centro Fond | Peptides |
| AU2013334180A1 (en) * | 2012-10-25 | 2015-05-14 | The Children's Hospital Of Philadelphia | Affinity peptide-modified particles and targeted drug delivery methods |
| GB201508024D0 (en) * | 2015-05-11 | 2015-06-24 | Haemostatix Ltd | Haemostatic compositions |
| WO2017103914A1 (en) | 2015-12-17 | 2017-06-22 | Regentis Biomaterials Ltd. | Ready for use organic solvent free compositions comprising protein-polymer conjugates and uses thereof |
| WO2020113090A1 (en) | 2018-11-30 | 2020-06-04 | Cellphire, Inc. | Platelets as delivery agents |
| US11767511B2 (en) | 2018-11-30 | 2023-09-26 | Cellphire, Inc. | Platelets as delivery agents |
| CA3138529C (en) | 2019-05-03 | 2025-10-07 | Cellphire Inc | Materials and methods for producing blood products |
| CN110448719B (zh) * | 2019-06-28 | 2020-05-22 | 浙江大学 | 一种促进凝血的丝素-多肽电纺膜及其制备方法 |
| WO2021034719A1 (en) | 2019-08-16 | 2021-02-25 | Cellphire, Inc. | Thrombosomes as an antiplatelet agent reversal agent |
| CA3170134A1 (en) | 2020-02-04 | 2021-08-12 | Cellphire, Inc. | Treatment of von willebrand disease |
| US20220273724A1 (en) | 2021-02-17 | 2022-09-01 | Cellphire Inc. | Freeze-dried platelet derivative compositions for treating antiplatelet induced coagulopathy |
| CN118302431A (zh) * | 2021-10-15 | 2024-07-05 | 北卡罗来纳大学 | 用于纯化生物流体的组合物和方法 |
| WO2024163622A1 (en) * | 2023-01-31 | 2024-08-08 | North Carolina State University | Compositions and methods for purifying biological fluids |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5357042A (en) * | 1984-04-23 | 1994-10-18 | The General Hospital Corporation | Synthetic peptides capable of eliciting fibrin-specific monoclonal antibodies lacking fibrinogen-cross-reactivity |
| US6391343B1 (en) * | 1991-01-15 | 2002-05-21 | Hemosphere, Inc. | Fibrinogen-coated particles for therapeutic use |
| DE4310632A1 (de) | 1993-04-01 | 1994-10-06 | Merck Patent Gmbh | Lineare Adhäsionsinhibitoren |
| CN1175208A (zh) * | 1994-12-16 | 1998-03-04 | 安达里斯有限公司 | 交联的微粒及其作为治疗载体的用途 |
| EP1028752B1 (en) | 1996-10-21 | 2004-12-15 | Quadrant Drug Delivery Limited | Platelet substitutes and conjugation methods suitable for their preparation |
| GB9724143D0 (en) * | 1997-11-14 | 1998-01-14 | Andaris Ltd | Pharmaceutical conjugate |
| CA2320219A1 (en) | 1998-02-20 | 1999-08-26 | Quadrant Healthcare (Uk) Limited | Products comprising fibrinogen for use in therapy |
| US20040127416A1 (en) | 2002-11-15 | 2004-07-01 | Massia Stephen P. | Therapeutic bioconjugates |
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2003
- 2003-10-07 GB GBGB0323378.0A patent/GB0323378D0/en not_active Ceased
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2004
- 2004-10-07 CN CNA200480029425XA patent/CN1863560A/zh active Pending
- 2004-10-07 JP JP2006530592A patent/JP4938454B2/ja not_active Expired - Fee Related
- 2004-10-07 CA CA2541005A patent/CA2541005C/en not_active Expired - Fee Related
- 2004-10-07 WO PCT/GB2004/004235 patent/WO2005035002A1/en not_active Ceased
- 2004-10-07 EP EP04768770.2A patent/EP1677829B1/en not_active Expired - Lifetime
- 2004-10-07 US US10/574,872 patent/US20080064628A1/en not_active Abandoned
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2006
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|---|---|
| AU2004280115A1 (en) | 2005-04-21 |
| EP1677829B1 (en) | 2014-12-24 |
| US20080064628A1 (en) | 2008-03-13 |
| GB0323378D0 (en) | 2003-11-05 |
| EP1677829A1 (en) | 2006-07-12 |
| JP2011184465A (ja) | 2011-09-22 |
| CA2541005A1 (en) | 2005-04-21 |
| AU2004280115B2 (en) | 2011-03-24 |
| IL174580A0 (en) | 2006-08-20 |
| WO2005035002A1 (en) | 2005-04-21 |
| JP2007507480A (ja) | 2007-03-29 |
| CN1863560A (zh) | 2006-11-15 |
| CA2541005C (en) | 2012-05-08 |
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