CN1863521B - 用于减少皮脂产生的包含丙二酰胺衍生物的药物组合物 - Google Patents
用于减少皮脂产生的包含丙二酰胺衍生物的药物组合物 Download PDFInfo
- Publication number
- CN1863521B CN1863521B CN2004800294673A CN200480029467A CN1863521B CN 1863521 B CN1863521 B CN 1863521B CN 2004800294673 A CN2004800294673 A CN 2004800294673A CN 200480029467 A CN200480029467 A CN 200480029467A CN 1863521 B CN1863521 B CN 1863521B
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- China
- Prior art keywords
- phenyl
- chemical compound
- alkyl
- hydrogen
- independently
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- Expired - Fee Related
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/664—Amides of phosphorus acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
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- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
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- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
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- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
Description
时间(min) | 溶剂A(%) | 溶剂B(%) | 流速(mL/min) |
0 | 99 | 1 | 2 |
2 | 96 | 4 | 2 |
6 | 60 | 40 | 2 |
7 | 5 | 95 | 2 |
10 | 5 | 95 | 2 |
10.1 | 99 | 1 | 2 |
Claims (15)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50998403P | 2003-10-09 | 2003-10-09 | |
US60/509,984 | 2003-10-09 | ||
PCT/IB2004/003156 WO2005034931A1 (en) | 2003-10-09 | 2004-09-27 | Pharmaceutical compositions comprising malonamide derivatives for decreasing sebum production |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1863521A CN1863521A (zh) | 2006-11-15 |
CN1863521B true CN1863521B (zh) | 2012-01-25 |
Family
ID=34435045
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2004800294673A Expired - Fee Related CN1863521B (zh) | 2003-10-09 | 2004-09-27 | 用于减少皮脂产生的包含丙二酰胺衍生物的药物组合物 |
Country Status (20)
Country | Link |
---|---|
US (3) | US7615230B2 (zh) |
EP (1) | EP1673077B1 (zh) |
JP (1) | JP2007508291A (zh) |
KR (1) | KR100786436B1 (zh) |
CN (1) | CN1863521B (zh) |
AR (1) | AR046176A1 (zh) |
AT (1) | ATE409470T1 (zh) |
AU (1) | AU2004280134B2 (zh) |
BR (1) | BRPI0415136A (zh) |
CA (1) | CA2541814C (zh) |
DE (1) | DE602004016874D1 (zh) |
DK (1) | DK1673077T3 (zh) |
ES (1) | ES2313065T3 (zh) |
IL (1) | IL174507A0 (zh) |
MX (1) | MXPA06003960A (zh) |
NO (1) | NO20061277L (zh) |
RU (1) | RU2342930C2 (zh) |
TW (1) | TWI286479B (zh) |
WO (1) | WO2005034931A1 (zh) |
ZA (1) | ZA200602840B (zh) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2004280134B2 (en) * | 2003-10-09 | 2007-10-11 | Medicis Pharmaceutical Corporation | Pharmaceutical compositions comprising malonamide derivatives for decreasing sebum production |
WO2006037468A1 (en) * | 2004-09-30 | 2006-04-13 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Hiv reverse transcriptase inhibitors |
KR100906288B1 (ko) * | 2005-02-24 | 2009-07-06 | 워너-램버트 캄파니 엘엘씨 | 결정질 acat 억제제 |
US20070142255A1 (en) * | 2005-12-16 | 2007-06-21 | Conopco, Inc., D/B/A Unilever | Skin benefit composition and a method for using the same |
ATE506343T1 (de) * | 2007-03-15 | 2011-05-15 | Hoffmann La Roche | Malonamide als orexin-antagonisten |
US20080254074A1 (en) * | 2007-04-11 | 2008-10-16 | Conopco, Inc., D/B/A Unilever | Composition and method for regulating sebum flow |
FR2918889B1 (fr) * | 2007-07-19 | 2009-10-23 | Galderma Res & Dev | Utilisation de l'eflucimibe pour la preparation d'un medicament destine a prevenir ou a traiter une maladie due a un dysfonctionnement des glandes sebacees chez l'homme ou l'animal |
FR2918890A1 (fr) * | 2007-07-19 | 2009-01-23 | Galderma Res & Dev | Utilisation du pactimibe pour la preparation d'un medicament destine a prevenir ou a traiter une maladie due a un dysfonctionnement des glandes sebacees chez l'homme ou l'animal |
CN101502541B (zh) * | 2008-02-04 | 2011-12-28 | 成都地奥九泓制药厂 | 安息香属植物及其提取物的用途 |
FR2938342A1 (fr) * | 2008-11-13 | 2010-05-14 | Galderma Res & Dev | Ciblage de modulateurs de ces1 et/ou ces3 dans le traitement de l'acne, d'une dermatite seborrheique ou de l'hyperseborrhee |
FR2946346B1 (fr) | 2009-06-05 | 2011-05-20 | Galderma Res & Dev | Nouveaux derives dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant. |
FR2946342B1 (fr) | 2009-06-05 | 2011-06-24 | Galderma Res & Dev | Nouveaux derives de dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant. |
FR2946340B1 (fr) | 2009-06-05 | 2011-06-24 | Galderma Res & Dev | Nouveaux n-phenyl acetamie, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant. |
FR2946345B1 (fr) | 2009-06-05 | 2011-05-20 | Galderma Res & Dev | Nouveaux derives dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant. |
WO2015048543A1 (en) * | 2013-09-26 | 2015-04-02 | Atterocor, Inc. | Treating disorders associated with aberrant adrenocortical cell behavior |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6133326A (en) * | 1994-08-31 | 2000-10-17 | Pfizer Inc | Compositions and methods for decreasing sebum production |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4299845A (en) | 1980-04-14 | 1981-11-10 | Schering Corporation | Dermatological compositions and methods of use therefor |
AU6659090A (en) * | 1989-11-16 | 1991-06-13 | Warner-Lambert Company | Acat inhibitors |
DE4008501A1 (de) | 1989-12-18 | 1991-06-20 | Windmoeller & Hoelscher | Druckmaschine mit presseurs mit austauschbaren huelsenfoermigen presseurmaenteln |
US5362878A (en) | 1991-03-21 | 1994-11-08 | Pfizer Inc. | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) |
AP2002002612A0 (en) | 2000-02-02 | 2002-09-30 | Warner Lambert Co | Dual inhibitors of cholesterol ester and wax ester synthesis for sebaceous gland disorders |
EP1281399A3 (en) | 2001-08-01 | 2004-02-11 | Warner-Lambert Company | Dual inhibitors of wax ester and cholesteryl ester synthesis for inhibiting sebum production |
AU2004280134B2 (en) * | 2003-10-09 | 2007-10-11 | Medicis Pharmaceutical Corporation | Pharmaceutical compositions comprising malonamide derivatives for decreasing sebum production |
-
2004
- 2004-09-27 AU AU2004280134A patent/AU2004280134B2/en not_active Ceased
- 2004-09-27 CN CN2004800294673A patent/CN1863521B/zh not_active Expired - Fee Related
- 2004-09-27 DK DK04769499T patent/DK1673077T3/da active
- 2004-09-27 DE DE602004016874T patent/DE602004016874D1/de active Active
- 2004-09-27 ES ES04769499T patent/ES2313065T3/es active Active
- 2004-09-27 CA CA2541814A patent/CA2541814C/en not_active Expired - Fee Related
- 2004-09-27 MX MXPA06003960A patent/MXPA06003960A/es active IP Right Grant
- 2004-09-27 KR KR1020067006717A patent/KR100786436B1/ko not_active IP Right Cessation
- 2004-09-27 JP JP2006530738A patent/JP2007508291A/ja not_active Ceased
- 2004-09-27 EP EP04769499A patent/EP1673077B1/en not_active Not-in-force
- 2004-09-27 WO PCT/IB2004/003156 patent/WO2005034931A1/en active IP Right Grant
- 2004-09-27 RU RU2006111458/15A patent/RU2342930C2/ru active
- 2004-09-27 BR BRPI0415136-4A patent/BRPI0415136A/pt not_active IP Right Cessation
- 2004-09-27 AT AT04769499T patent/ATE409470T1/de not_active IP Right Cessation
- 2004-10-05 US US10/958,306 patent/US7615230B2/en not_active Expired - Fee Related
- 2004-10-07 AR ARP040103633A patent/AR046176A1/es not_active Application Discontinuation
- 2004-10-07 TW TW093130426A patent/TWI286479B/zh not_active IP Right Cessation
-
2006
- 2006-03-21 NO NO20061277A patent/NO20061277L/no not_active Application Discontinuation
- 2006-03-23 IL IL174507A patent/IL174507A0/en unknown
- 2006-04-06 ZA ZA200602840A patent/ZA200602840B/xx unknown
-
2009
- 2009-09-29 US US12/568,763 patent/US8409595B2/en not_active Expired - Fee Related
-
2013
- 2013-03-04 US US13/783,936 patent/US20130178446A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6133326A (en) * | 1994-08-31 | 2000-10-17 | Pfizer Inc | Compositions and methods for decreasing sebum production |
Non-Patent Citations (1)
Title |
---|
第5页第15、16行,权利要求书,实施例,表1-3. |
Also Published As
Publication number | Publication date |
---|---|
US8409595B2 (en) | 2013-04-02 |
MXPA06003960A (es) | 2006-07-05 |
ATE409470T1 (de) | 2008-10-15 |
NO20061277L (no) | 2006-06-29 |
CA2541814C (en) | 2010-02-23 |
US7615230B2 (en) | 2009-11-10 |
IL174507A0 (en) | 2006-08-01 |
US20050079144A1 (en) | 2005-04-14 |
AU2004280134B2 (en) | 2007-10-11 |
US20100113601A1 (en) | 2010-05-06 |
EP1673077B1 (en) | 2008-10-01 |
BRPI0415136A (pt) | 2006-11-28 |
DK1673077T3 (da) | 2008-12-08 |
US20130178446A1 (en) | 2013-07-11 |
RU2006111458A (ru) | 2007-10-27 |
KR20060085658A (ko) | 2006-07-27 |
KR100786436B1 (ko) | 2007-12-17 |
RU2342930C2 (ru) | 2009-01-10 |
ES2313065T3 (es) | 2009-03-01 |
EP1673077A1 (en) | 2006-06-28 |
DE602004016874D1 (de) | 2008-11-13 |
ZA200602840B (en) | 2007-09-26 |
CN1863521A (zh) | 2006-11-15 |
AU2004280134A1 (en) | 2005-04-21 |
JP2007508291A (ja) | 2007-04-05 |
AR046176A1 (es) | 2005-11-30 |
CA2541814A1 (en) | 2005-04-21 |
WO2005034931A1 (en) | 2005-04-21 |
TWI286479B (en) | 2007-09-11 |
TW200517137A (en) | 2005-06-01 |
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