CN1861071A - Medicine and/or health-care products prepd. by using malic polyphenols to regulate immunity - Google Patents
Medicine and/or health-care products prepd. by using malic polyphenols to regulate immunity Download PDFInfo
- Publication number
- CN1861071A CN1861071A CN 200510200272 CN200510200272A CN1861071A CN 1861071 A CN1861071 A CN 1861071A CN 200510200272 CN200510200272 CN 200510200272 CN 200510200272 A CN200510200272 A CN 200510200272A CN 1861071 A CN1861071 A CN 1861071A
- Authority
- CN
- China
- Prior art keywords
- application
- apple polyphenol
- medicine
- immunologic function
- health product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
An application of malic polyphenol in preparing the medicine and/or health-care food for regulating immunity is disclosed.
Description
Technical field
The present invention relates to the medicine or the new application of health care of apple polyphenol, be specifically related to apple polyphenol and regulate the medicine of immunologic function and/or the application in the health product, belong to natural drug or field of health care products in preparation.
Background technology
Functions of immune system is extremely important to humans and animals.In recent years, the crowd of immune disorder, immunologic hypofunction increases gradually, is also being increased by the number of patients that causes some diseases.Seeking development vegetalitas immunomodulator nontoxic, that have no side effect is important work.
Apple polyphenol is the polyphenols that extracts from Fructus Mali pumilae, and especially immature Fructus Mali pumilae (green apple) content is more, from economic angle, generally never extracts in the transparent apple.
The Main Ingredients and Appearance of apple polyphenol has: Fructus Mali pumilae procyanidin (Grape Procyanidins), and about 50% (this is the main active ingredient of apple polyphenol), existing at present content is at the Fructus Mali pumilae procyanidin more than 80%; Chlorogenic acid about 25%; Catechin, epicatechin about 15%; Other polyphenol about 10%.
The Fructus Mali pumilae procyanidin is the main active ingredient of apple polyphenol, and existing at present content is at the Fructus Mali pumilae procyanidin more than 80%.
The extracting method of apple polyphenol belongs to mature technology, and there are the commodity of apple polyphenol in domestic many enterprises at present, and content is more than 80%, and many commodity content are higher than 95%.
The known effect of apple polyphenol has antioxidation, anticancer, arteriosclerosis, hair growth promoting, antibiotic, antiviral.Up to the present, the relevant apple polyphenol of Shang Weijian is used to regulate the report of immunologic function.
Summary of the invention
The purpose of this invention is to provide new medicine of apple polyphenol or healthcare applications, promptly apple polyphenol is regulated the medicine of immunologic function and/or the application in the health product in preparation.
Particularly, application of the present invention is characterized in that described " medicine and/or health product " are medicine.Also promptly, application of the present invention is characterized in that the application of apple polyphenol in the medicine of preparation adjusting immunologic function.
Particularly, application of the present invention is characterized in that described " medicine and/or health product " are health product.Also promptly, application of the present invention is characterized in that the application of apple polyphenol in the health product of preparation adjusting immunologic function.
Application of the present invention, described adjusting immunologic function also claims immunomodulating.
Application of the present invention, " medicine and/or the health product " of regulating immunologic function are for also can be described as " immunomodulator ".Also promptly, application of the present invention is characterized in that the application of apple polyphenol in the preparation immunomodulator.
Application of the present invention is characterized in that described adjusting immunologic function is for strengthening (or raising) immunologic function.Described enhancing (or raising) immunologic function also is the immune power of enhancing (or raising) of popular appellation.
Application of the present invention is characterized in that described adjusting immunologic function is suitable inhibition (or reduction) immunologic function.
Application of the present invention, described apple polyphenol are the Fructus Mali pumilae total polyphenols.
Application of the present invention, described apple polyphenol are the Fructus Mali pumilae procyanidin.The Fructus Mali pumilae procyanidin is tool active ingredient in the apple polyphenol, also is the effective constituent that mainly contains of apple polyphenol.
Application of the present invention, described apple polyphenol are extract.
Application of the present invention, apple polyphenol also can be the former plants that contains apple polyphenol.
Application of the present invention, described apple polyphenol comprise apple polyphenol derivant.
Described derivant comprises the polymer of apple polyphenol, and apple polyphenol is by the product of methods such as physics, chemistry acquisition, such as salt, the ester of apple polyphenol.
The preparation method of apple polyphenol extract has multiple, and multiple report is arranged, and belongs to known technology and maturation process, and existing many commodity sellings.
The apple polyphenol or derivatives thereof all can be used as medicine and/or the health product that immunologic function is regulated in preparation.
Application of the present invention, described medicine oral administration, Sublingual, external, transdermal, injection, instillation, mucosa, spraying, transfusion, rectum or parenterai administration.
Application of the present invention, the administration of described health product oral administration.
Apple polyphenol or derivatives thereof of the present invention, be that medicine is or/and the main active constituent of health product, when the preparation dosage form, can also comprise that adding one or more is selected from excipient substances such as conventional excipient, flavoring agent, disintegrating agent, antiseptic, lubricant, wetting agent, binding agent, solvent, thickening agent, solubilizing agent, makes any dosage form that is suitable for drug use clinically or uses as health product.
Application of the present invention, described medicine comprises tablet, pill, capsule, granule, liposome, oral liquid, injection, infusion solution, aerosol or nasal drop.
Application of the present invention, described health product are oral formulations.
Application of the present invention, the mass percentage content of described apple polyphenol in medicine and/or health product is 1% to 100%.
Application of the present invention is characterized in that the mass percentage content of described apple polyphenol in medicine and/or health product is 20% to 95%.
Application of the present invention is characterized in that the mass percentage content of described apple polyphenol in medicine and/or health product is 50% to 80%.
Application of the present invention, the implication of described " medicine and/or health product " are that apple polyphenol can be used to prepare medicine, also can be used to prepare health product; The preparation of apple polyphenol preparation can be used as drug use, also can be used as health product and uses.
Because apple polyphenol extracts from common edible fruits Fructus Mali pumilae, does not have poison, therefore can be applied to health product.
Application of the present invention, described health product comprise health food, also comprise health care medicine.
Effect of the present invention
Select the female secondary mice in Kunming for use, body weight 18-22g is divided into four groups at random.Select content 95% apple polyphenol (wherein Fructus Mali pumilae procyanidin＞60%) for use.
Press the general recommendation use amount (2400mg/60kg/d) of human body of apple polyphenol, design divides high, medium and low three dosage groups (three groups of 1 times, 2 times, 5 times of being equivalent to the human body recommended amounts in proportion respectively), 10 every group.Adopt the pharmaceutical aqueous solution gastric infusion, once a day.Matched group is irritated distilled water.Measure every immune indexes after 20 days.
The result:
1, to the influence of mice delayed allergy (DTH)
The influence of table 1 pair mice delayed allergy (DTH)
| Group | Size of animal (only) | Swelling degree of the paw (mm) |
| Matched group | 10 | 0.561±0.05 |
| Low dosage | 10 | 0.471±0.05 |
| Middle dosage | 10 | 0.497±0.05 |
| High dose | 10 | 0.481±0.07 |
2, to the exponential influence of normal mouse immune organ (thymus)
The table 2 pair exponential influence of normal mouse immune organ (thymus)
| Group | Size of animal (only) | Thymus index (mg) |
| Matched group | 10 | 2.97±0.56 |
| Low dosage | 10 | 3.31±0.65 |
| Middle dosage | 10 | 3.55±0.73 |
| High dose | 10 | 3.49±0.71 |
3, to the influence of macrophage phagocytosis of mice
The influence of table 3 pair mice carbon clearance
| Group | Size of animal (only) | Phagocytic index (α) |
| Matched group | 10 | 3.975±0.54 |
| Low dosage | 10 | 5.451±0.79 |
| Middle dosage | 10 | 6.590±0.73 |
| High dose | 10 | 6.210±0.71 |
4, to the influence of mouse lymphocyte conversion ratio
The influence of table 4 pair mouse lymphocyte conversion ratio
| Group | Size of animal (only) | Conversion ratio |
| Matched group | 10 | 0.4920±0.0705 |
| Low dosage | 10 | 0.7265±0.0773 |
| Middle dosage | 10 | 0.7857±0.0565 |
| High dose | 10 | 0.7356±0.0503 |
More than test shows that apple polyphenol has the effect of tangible adjusting immunologic function, is embodied in: 1, strengthen (raising) immunologic function; 2, medicine is high to doses, then oppositely regulates immunologic function.Therefore apple polyphenol of the present invention can the two-ways regulation immunity.
The specific embodiment
Embodiment 1
Apple polyphenol 800 grams
Lactose 200 grams
Above-mentioned component is stirred, encapsulated, every filling 0.5 gram.Make 2000 of apple polyphenol capsules, every capsules contains 400 milligrams of apple polyphenols.
Embodiment 2
Apple polyphenol 1000 grams
Apple polyphenol is encapsulated, every filling 0.5 gram.Make 2000 of the former polyphenol capsules of Fructus Mali pumilae, every capsules contains 500 milligrams of apple polyphenols.
Embodiment 3
Apple polyphenol 800 grams
Starch 200 grams
Above-mentioned component is stirred, encapsulated, every filling 0.5 gram.Make 2000 of capsules that contain apple polyphenol, every capsules contains 400 milligrams of apple polyphenols.
Embodiment 4
Apple polyphenol 600 grams
Starch 200 grams
Sucrose 200 grams
Above-mentioned component is stirred, moistening, tabletting.Make the apple polyphenol tablet.
Embodiment 5
Apple polyphenol 250 grams
2000 milliliters of distilled water
Stevioside 1 gram
Apple polyphenol is dissolved in stirring and evenly mixing in the distilled water, adds stevioside, stirring and evenly mixing, bottling, every bottled 10 milligrams, sterilization makes oral liquid.
Embodiment 6
Apple polyphenol 400 grams
Starch 200 grams
Sucrose 300 grams
Xylitol 100 grams
Above-mentioned component is stirred, moistening, tabletting.Make the apple polyphenol buccal tablet.
Industrial applicability
The present invention has enlarged the range of application of apple polyphenol, has improved its exploitation and has been worth. Regulate medicine and/or the health products of immunologic function with apple polyphenol preparation of the present invention, the preparation method is simple, raw material is easy to get, and has industrial applicibility.
Claims (10)
1. apple polyphenol is regulated the medicine of immunologic function and/or the application in the health product in preparation.
2. according to the application of claim 1, it is characterized in that the application of apple polyphenol in the medicine of preparation adjusting immunologic function.
3. according to the application of claim 1, it is characterized in that the application of apple polyphenol in the health product of preparation adjusting immunologic function.
4. according to claim 1,2 or 3 arbitrary described application, it is characterized in that described adjusting immunologic function is a raise immunity.
5. according to claim 1,2 or 3 arbitrary described application, it is characterized in that described adjusting immunologic function is for suitably suppressing immunologic function.
6. according to claim 1,2 or 3 arbitrary described application, it is characterized in that described apple polyphenol is the Fructus Mali pumilae procyanidin.
7. according to claim 1,2 or 3 arbitrary described application, described apple polyphenol comprise apple polyphenol derivant.
8. according to the application of claim 1 or 2 arbitrary described application, it is characterized in that described medicine oral administration, Sublingual, external, transdermal, injection, instillation, mucosa, spraying, transfusion, rectum or parenterai administration.
9. according to claim 1,2 or 3 arbitrary described application, it is characterized in that described medicine and/or health product comprise tablet, pill, capsule, granule, liposome, oral liquid, injection or infusion solution.
10. according to claim 1,2 or 3 arbitrary described application, it is characterized in that the mass percentage content of described apple polyphenol in medicine and/or health product is 20% to 95%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510200272 CN1861071A (en) | 2005-05-12 | 2005-05-12 | Medicine and/or health-care products prepd. by using malic polyphenols to regulate immunity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510200272 CN1861071A (en) | 2005-05-12 | 2005-05-12 | Medicine and/or health-care products prepd. by using malic polyphenols to regulate immunity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1861071A true CN1861071A (en) | 2006-11-15 |
Family
ID=37388658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510200272 Pending CN1861071A (en) | 2005-05-12 | 2005-05-12 | Medicine and/or health-care products prepd. by using malic polyphenols to regulate immunity |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1861071A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101810697A (en) * | 2010-05-13 | 2010-08-25 | 天津市壹杯红生物技术有限公司 | Application of apple polyphenols for preparing liver-protecting medicines, health-care foods or foods |
| CN103763942A (en) * | 2011-08-24 | 2014-04-30 | 雀巢产品技术援助有限公司 | Epicatechin for alleviating symptoms of allergy |
| CN103918589A (en) * | 2014-04-24 | 2014-07-16 | 厦门兴牧威动物保健品有限公司 | Animal health product capable of improving survival rate of shrimp fry in long distance transportation |
| CN105879015A (en) * | 2014-10-23 | 2016-08-24 | 大连世纪新源技术开发有限公司 | Deuterium depleted water (DDW) oral liquid capable of preventing cancer and aging |
-
2005
- 2005-05-12 CN CN 200510200272 patent/CN1861071A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101810697A (en) * | 2010-05-13 | 2010-08-25 | 天津市壹杯红生物技术有限公司 | Application of apple polyphenols for preparing liver-protecting medicines, health-care foods or foods |
| CN101810697B (en) * | 2010-05-13 | 2012-05-23 | 天津市壹杯红生物技术有限公司 | Application of apple polyphenols for preparing liver-protecting medicines, health-care foods or foods |
| CN103763942A (en) * | 2011-08-24 | 2014-04-30 | 雀巢产品技术援助有限公司 | Epicatechin for alleviating symptoms of allergy |
| CN103918589A (en) * | 2014-04-24 | 2014-07-16 | 厦门兴牧威动物保健品有限公司 | Animal health product capable of improving survival rate of shrimp fry in long distance transportation |
| CN103918589B (en) * | 2014-04-24 | 2016-03-23 | 厦门兴牧威动物保健品有限公司 | A kind of animal health-care product improving shrimp seedling long-distance transport survival rate |
| CN105879015A (en) * | 2014-10-23 | 2016-08-24 | 大连世纪新源技术开发有限公司 | Deuterium depleted water (DDW) oral liquid capable of preventing cancer and aging |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106963820A (en) | The purposes of Piper plants essential oil | |
| Khursheed et al. | Phytochemical and pharmacological investigations on adhatoda zeylanica (medic.): A review | |
| CN1857475A (en) | Composition for preventing and treating cardias and cerebral vascular diseases and its application | |
| CN1943618A (en) | Red sage root effective part standard extract and its preparing method and use | |
| Sunder et al. | Effect of Morinda citrifolia in growth, production and immunomodulatory properties in livestock and poultry: a review | |
| CN110680808B (en) | Amino sugar chewable tablet and preparation method thereof | |
| CN1861071A (en) | Medicine and/or health-care products prepd. by using malic polyphenols to regulate immunity | |
| EP2891496B1 (en) | PHARMACEUTICAL COMPOSITION CONTAINING COMPLEX EXTRACT OF CRATAEGI FRUCTUS and CITRI PERICARPIUM AS AN ACTIVE INGREDIENT FOR TREATING OR PREVENTING OBESITY OR LIPID-RELATED METABOLIC DISEASES | |
| JP2015017044A (en) | Agent for fat accumulation inhibition and/or fat accumulation amount reduction | |
| KR102448526B1 (en) | A preventing composition comprising CAPE, Quercetin and Chrysin for anti-inflammation | |
| CN1788755A (en) | Framberry leaf extract effective part and its composition and uses | |
| CN1304769A (en) | Blood-cleaning pill | |
| CN1857399A (en) | Composition for preventing and treating stomatosis and its preparing method | |
| CN1857502A (en) | Chinese medicine liniment for treating toothache and its preparing method | |
| KR101899555B1 (en) | A composition for improving, preventing and treating arthritis comprising Stewartia koreana extract and Rhus verniciflua stokes extract | |
| CN104997018A (en) | Yew enzyme health-care product as well as preparation method and application thereof | |
| CN1401365A (en) | Chinese health medicine | |
| KR101645535B1 (en) | Composition containing glucosamine with anti-immflammatory and pain repression effect | |
| CN1954878A (en) | Preparation method of ginger allicin immunity soft capsult | |
| KR101423316B1 (en) | Composition for prevention or treatment of osteoarthritis including extracts of Phyllanthus tenellus | |
| CN101574396A (en) | Compound preparation of fructus schisandrae and evening primrose CO* supercritical extract and preparation process | |
| CN1861072A (en) | Use of malic polyphenols for preparing medicines to treat bronchitis or asthma | |
| KR101745126B1 (en) | Composition comprising extract of mixed herb medicine for preventing or treating inflammatory disease | |
| CN106983771B (en) | Medicine and composition for preventing and treating hippocampus head ulceration | |
| KR101120000B1 (en) | Composition comprising Acanthopanacis Cortex extract for preventing or treating gastrointestinal disease |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |