CN1857485A - Heart-nourishing tranquilizing Chinese medicine and its preparing method - Google Patents
Heart-nourishing tranquilizing Chinese medicine and its preparing method Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine for nourishing heart and tranquilizing. The Chinese medicine is developed on the basis of Golden Cabinet Ziziphi Spiosae Decoration and through eliminating anemarrhena rhizome and Chuanxiong rhizome and adding polygala root, fleeceflower stem, medicated leaven, red sage and cape jasmine. The Chinese medicine has the functions of nourishing heart, tranquilizing, invigorating spleen and stomach, clearing away heat and relieving restlessness, and is used mainly in treating neurasthenia, terror, amnesia, etc.
Description
Technical field
The present invention relates to a kind of Chinese medicine and preparation method thereof with tranquilizing by nourishing the heart.
Background technology
Be insomnia, be referred to as usually to have a sleepless night, be meant to be difficult for falling asleep, or sleep that very then the disease of thorough sleeplessness is characteristics can not obtain ortho sleep and easily awake.Heavy when light during symptom, normal protracted course of disease." insomnia " only is a common symptoms of multiple disease in the modern medicine. a lot of reasons all can cause insomnia, be the catatonic, especially the common sympton of neurastheniac. the incidence rate of being insomnia in the crowd is quite high, but the Epidemiological study data of rare relevant insomnia.Below only from the epidemiologic data of neurasthenia's (neurastheniac nearly all has insomnia), the height of the sickness rate of insomnia as can be seen just.According to 10830 philtrums of seven kinds of different occupation of Sichuan investigation, neurasthenia symptom continues that the person accounts for 5.9% more than 3 months, wherein government functionary and teacher's sickness rate the highest (accounting for 8.6-11.3%); Shanghai is investigated in 5 universities. and student's prevalence is 0.3-10%; Efficiency in Buildings in Tianjin Area survey result, neurasthenic sickness rate are 9.1 ‰, and wherein the women is up to 15.78 ‰, and the male is 2.3 ‰; Again according to the whole nation 12 areas to neurasthenia's Epidemiological study data, neurasthenia's total prevalence rate is 13.03 ‰.Therefore. the incidence rate of insomnia is quite high, and the insomniac often with mental fatiguability, memory subtract late, symptom such as headache, loss of appetite and general malaise, have a strong impact on life quality and work and study ability.
Name sides in ancient times " suanzaoren decoction " come from the Han dynasty Zhang Zhongjing " Medical Treasures of the Golden Chamber. arthralgia due to stagnation of blood asthenia abnormal pulse card also controls the 6th ", this side is by Semen Ziziphi Spinosae, Radix Glycyrrhizae, the Rhizoma Anemarrhenae, Poria, Rhizoma Chuanxiong composition.Later age side's book is discussed this Fang Duoyou.Show the Jing-Yue Complete Works cloud as Zhang Jiebin: " if excessive thinking is had a guilty conscience and is insomnia and little double dysphoria with smothery sensation person, soup or suanzaoren decoction nourish heart." explain to praise and put into words: " and consumptive disease with restlessness. be the disease of disarmony between the heart and kidney, kidney water is not submitted heart-fire, and heart-fire does not have system, the insomnia so be tired of.The side is monarch with Semen Ziziphi Spinosae, and the nourishing kidney of the Rhizoma Anemarrhenae of holding concurrently is assistant, and Poria, Radix Glycyrrhizae are in harmonious proportion therebetween.Rhizoma Chuanxiong people blood system is tired of also and separate the dry of heart-fire." Zhang Luyu is Sino-Japan in " ancestral side ": " and deficiency of the liver and fire of moxibustion is taken advantage of also, Gu Te gets Semen Ziziphi Spinosae based on the peace liver and gall, Rhizoma Chuanxiong withers blood with nourishing the liver slightly, Poria, Radix Glycyrrhizae are earthed up with Rong Mu. Rhizoma Anemarrhenae pathogenic fire reducing is with relieving restlessness. the agent of this Heibei provincial opera building is also." You Zaijing says in " Medical Treasures of the Golden Chamber innermost being ": " people's soul of sleeping is then resided in order, and sleeping then, soul is hidden in liver.The people of asthenia. flourish under the irritability, then soul must not be hidden.So soul is not hidden insomnia, and Semen Ziziphi Spinosae tonifying liver astringing QI should think monarch, and soul is neither returned appearance, must have turbid expectorant dryness-fire to seize an opportunity and attacks its house person, and tired reason is done also, thus dry with the Rhizoma Anemarrhenae, Radix Glycyrrhizae heat clearing away taste, Poria, Rhizoma Chuanxiong circulation of qi promoting expectorant.All institute its soul of residence is also in the hope of controlling of liver." Wang recognizes Buddhist nunnery " collection of prescriptions with notes " day: " and the deficient consumptive disease with restlessness insomnia of controlling of gold. use suanzaoren decoction ..., the agent of this tonifying liver belongs to liver through day, then blood for sleeping in.High by herbal cloud, Semen Ziziphi Spinosae is fried with controlling milk-livered sleeplessness." Lee's jade or pearl earring minister says: " the deficiency dysphoric insomnia person, blood deficiency is given birth to interior-heat. and cloudy gas is not held back yet.Interior through day, gas is capable of sun.Yang-energy completely must not be gone into Yu Yin, cloudy gas thus order must not close the eyes, suanzaoren decoction nourish blood and yin fluid astringing gas also, " tail Tai Shi cloud: " and all diseases do not heal for a long time, and thin field is equipped with, the fever of the body antiperspirant of sleeping, palpitation with a distress feeling is insomnia, xerostomia is breathed heavily and is coughed, big loose stool. it is puckery to urinate.Drink is eaten tasteless person, suitable suanzaoren decoction.”
Ancient Chinese medicine doctor has to add to simplify on Zhong Jing suanzaoren decoction basis more to be cut out and uses.As the Ziziphi Spinosae soup of Sun Simiao supplement to Thousand Golden Prescriptions, main typhoid fever and tell down vexed weary gas insomnia side, back, with Zhong Jing Semen Ziziphi Spinosae Tonga Radix Ophiopogonis and Rhizoma Zingiberis.The little suanzaoren decoction of dark teacher of " medical secrets of official ", treatment asthenia insomnia, tired rather person side, with two liang in Rhizoma Zingiberis Recens, one adds two liang in osmanthus in the deficient suanzaoren decoction of gold.The contained suanzaoren decoction of Gong Qian virtuous " Wanbing Huichun, Curative Measures for All Diseases " adds Radix Ginseng, removes the Rhizoma Anemarrhenae, Rhizoma Chuanxiong, Radix Glycyrrhizae, and sleep and sit up in Zhiduo County." Bencao Tujing " carries: " the Hu Qiazhi insomnia of throbbing with fear that shakes has suanzaoren decoction, removes golden deficient side's the Rhizoma Anemarrhenae, and Rhizoma Chuanxiong adds Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis Recens.Therefore golden deficient suanzaoren decoction is the ancestral side of treatment restlessness of asrhenia type and insomnia, but ancient Chinese medicine doctor abides by Gu and do not model one's literary or artistic style on that of the ancients, and plus-minus is arranged more, has his own strong points.
Summary of the invention
The object of the present invention is to provide diseases such as a kind of neurasthenia of curing mainly, forgetful, the dreaminess insomnia of palpitation with fear, calentura agitation, malaise, have Chinese medicine of tranquilizing by nourishing the heart and preparation method thereof.
For achieving the above object, the technical solution used in the present invention is:
A kind of Chinese medicine with tranquilizing by nourishing the heart, it is the medicament that is prepared into by the following weight proportion raw material:
127～207 parts in 127～207 parts of Poria of 127～207 parts of Radix Polygalaes of 190～310 parts of Caulis Polygoni Multiflori of Semen Ziziphi Spinosae
63～103 parts in 63～103 portions of Radix Glycyrrhizaes of 63～103 parts of Massa Medicata Fermentata of 63～103 portions of Fructus Gardeniaes of Radix Salviae Miltiorrhizae
Above-mentioned a kind of Chinese medicine with tranquilizing by nourishing the heart, wherein the weight proportion of each raw material is:
147～187 parts in 147～187 parts of Poria of 147～187 parts of Radix Polygalaes of 220～280 parts of Caulis Polygoni Multiflori of Semen Ziziphi Spinosae
73～93 parts in 73～93 portions of Radix Glycyrrhizaes of 73～93 parts of Massa Medicata Fermentata of 73～93 portions of Fructus Gardeniaes of Radix Salviae Miltiorrhizae
Above-mentioned a kind of Chinese medicine with tranquilizing by nourishing the heart, wherein the weight proportion of each raw material is:
167 parts in 167 parts of Poria of 167 parts of Radix Polygalaes of 250 parts of Caulis Polygoni Multiflori of Semen Ziziphi Spinosae
83 parts in 83 portions of Radix Glycyrrhizaes of 83 parts of Massa Medicata Fermentata of 83 portions of Fructus Gardeniaes of Radix Salviae Miltiorrhizae
Above-mentioned a kind of preparation method of Chinese medicine with tranquilizing by nourishing the heart, described dosage form are that the processing step of preparation method of tablet is as follows:
(1), with after the Semen Ziziphi Spinosae parch, standby;
(2), Radix Glycyrrhizae, Massa Medicata Fermentata mixed powder be broken into fine powder after, standby;
(3), the Semen Ziziphi Spinosae Six-element Chinese medicine of Caulis Polygoni Multiflori, Radix Polygalae, Poria, Radix Salviae Miltiorrhizae, Fructus Gardeniae and step (1) preparation is decocted with water 2 times, for the first time add 12 times of water gagings, soaked 30 minutes, decocted 3 hours; For the second time add 10 times of water gagings, decocted 2 hours; Merge 2 times decoction liquor, filter, filtrate decompression is concentrated into when 60 ℃ of heat are surveyed, and relative density is 1.38 clear paste;
(4), add Radix Glycyrrhizae, Massa Medicata Fermentata fine powder and an amount of dextrin of step (2) preparation, mix and contain even system soft material, 14 mesh sieves are granulated, 60 ℃ of dryings, 12 mesh sieve granulate add 0.5% magnesium stearate, compacting in flakes, sugar coating, promptly.
The present invention removes the Rhizoma Anemarrhenae, the Rhizoma Chuanxiong of golden deficient suanzaoren decoction on the basis of name sides in original ancient times " suanzaoren decoction ", add Radix Polygalae, Caulis Polygoni Multiflori, Massa Medicata Fermentata, Radix Salviae Miltiorrhizae, Fructus Gardeniae and form.Radix Polygalae, Caulis Polygoni Multiflori, Radix Salviae Miltiorrhizae have been strengthened the merit that the suanzaoren decoction the liver benefiting nourishes heart. and Massa Medicata Fermentata increases the power of fourth Poria, Radix Glycyrrhizae invigorating the spleen and regulating the stomach, and Fructus Gardeniae is rushed down the fire of three warmers and relieving restlessness.Make full side's reinforcement and elimination in combination, deficiency and excess is also controlled.Can be used for that blood deficiency cloudy is lost, disorder of stomach-QI, the card of being insomnia due to the multiple factor such as disturb on the phlegm-fire.
The specific embodiment
The present invention is a kind of Chinese medicine with tranquilizing by nourishing the heart, and it is by Semen Ziziphi Spinosae, Caulis Polygoni Multiflori, and Radix Polygalae, Poria, Radix Salviae Miltiorrhizae, Fructus Gardeniae, Massa Medicata Fermentata, Radix Glycyrrhizae constitutes.
Selected medicine offers that ancient books is discussed and relevant modern study situation is as follows among the side of the present invention:
Semen Ziziphi Spinosae: nature and flavor are sweet to be done, nontoxic.GUIXIN, spleen, liver, gallbladder meridian.Useful liver blood.The moon that nourishes heart, the effect of mind tranquilizing and the heart calming.Cure mainly restlessness of asrhenia type and insomnia. palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility." not Lu " cloud: " main vexatious insomnia ".Zhu Zhen enjoys: " blood is not returned spleen and is dossed not peaceful person. should use this (Semen Ziziphi Spinosae) big reinforcing the heart spleen.Then blood return spleen and the five internal organs peaces and. doss from peaceful "." wooden grass is through dredging " day: " special tonifying liver gallbladder.Also be amusing again ".Supplement to the Herbal cloud: " give birth to of sleeping makes more, and must not sleep fries ".Wang Haogu day: " the milk-livered sleeplessness of smelting is cold also, fries clothes; Control somnolence due to gallbladder-excess, heat is also. give birth to and use "." book on Chinese herbal medicine converges and says " said: " astringing QI is calmed the nerves, and flourish muscle is supported marrow. the stomach function regulating activating the spleen ".Modern study: this product contains volume fatty oil and protein and sterol.The pharmacological research proof has calmness, syngignoscism; Analgesia, convulsion, cooling effect; Can make blood pressure drops, heart-block; The burn animal capable is improved survival rate, prolong life cycle.
Radix Polygalae: the toil temperature, nontoxic.Go into the heart, kidney channel.The function Fructus Alpiniae Oxyphyllae of calming the nerves. eliminate the phlegm, resolving depression.Cure mainly insomnia. palpitation with fear. cough. diseases such as excessive phlegm." wooden grass is just " cloud: " Radix Polygalae, the wholwe-hearted kidney of merit, so but frightened on the relieving palpitation, the peace that exorcises evil spirits dream "." the southern regions of the Yunnan Province book on Chinese herbal medicine " cloud: " it is bent, relieving convulsion to nourish heart, mind calming, and sputum looses." " book on Chinese herbal medicine justice " say: " Radix Polygalae.The flavor bitter in taste acting on the heart. the temperature promoting the circulation of blood. ... the hot temperature of the aggregation of its special main heart channel person, this blood of the heart with tonneau it, should its heart-yang of bestirring oneself. and beneficial people's wisdom." " book on Chinese herbal medicineization justice " says: " and go into the heart and have one's ideas straightened out, the medicine that should loose, all sputums lie prostrate the heart, the thinking of being jammed ... not peaceful for dossing ..., temporarily with the sharp key of eliminating phlegm. and make the motive open-minded. then the state of mind is certainly rather also ".Modern study: its root contains Saponin.Pharmacological action mainly contains phlegm-dispelling functions.
Caulis Polygoni Multiflori: nature and flavor are sweet, and little hardship is flat.Nontoxic, the popular feeling, Liver Channel.The function tranquilizing by nourishing the heart. collateral dredging dispels the wind.Cards such as Cure for insomnia impairment caused by overstrain." book on Chinese herbal medicine justice " cloud: " modern few to control night, peace is slept, and lid is got it and can be drawn sun and go into cloudy ear." " decoction pieces is newly joined " say: nourishing the liver and kidney, end sweating due to debility, the hypnosis of calming the nerves." modern study: contain emodin. compositions such as chrysophanol.Its pharmacological research data is very few.
Poria: do in the sweet Yunnan of nature and flavor.Nontoxic.Popular feeling spleen lung meridian.The function eliminating dampness and diuresis, beneficial Pi stomach function regulating, mind tranquilizing and the heart calming.Cure mainly dysuria, the edema whirlpool of expanding, phlegm retention cough with dyspnea, the forgetful card that waits of palpitating with fear." " property of medicine is sunk " side: " and appetizing. preventing or arresting vomiting is contrary.Kind tranquilizing mind." amplification on Canon of Materia Medica day: " and Poria, the merit of Poria cum Radix Pini row water is many, heart-spleen boosting can not fault also." " medication heart method " say " Poria ..., the panacea of dehumidifying also." modern study: sclerotium contains B-pachyman and acetyl pachymic acid, pachymic acid etc.Its pharmacological action has diuresis, and antibacterial action reduces gastric acid, effects such as prevention ulcer and blood sugar lowering.
Radix Salviae Miltiorrhizae: property is hidden bitter. is slightly cold.Nontoxic.Go into the heart, Liver Channel.Merit is arrogated to oneself blood circulation promoting and blood stasis dispelling. calming heart and tranquilizing mind, pain relieving.Control the palpitation with fear sleeplessness, angina pectoris. menoxenia, dysmenorrhea. abdominal pain due to blood stasis.Cards such as lumps in the chest and abdomen." the southern regions of the Yunnan Province book on Chinese herbal medicine " cloud: " reinforcing the heart sedate, calming heart and tranquilizing mind.Control forgetful, palpitation with a distress feeling, palpitation with fear is insomnia." " Chongqing hall random notes " day: " and heart storing spirit and main blood, heart-fire is too moving then refreshing uneasy, and so the fire during Radix Salviae Miltiorrhizae purifies the blood is the energy tranquilizing the mind." modern study: mainly contain compositions such as TANSHINONES, danshensu.Its pharmacological action: sedation. can prolong the length of one's sleep of barbital, other has effects such as blood vessel dilating.
Fructus Gardeniae: nature and flavor bitter cold.Nontoxic.Go into the heart, liver, lung, stomach warp.The relieving restlessness of function clearing away heat-fire.Removing heat from blood.Control multiple diseases such as calentura restlessness of asrhenia type and insomnia.The amplification on Canon of Materia Medica cloud: " after Zhong Jing controls diaphoresis and tells down, deficiency dysphoric insomnia." " medicine origin " say: " and treat exopathogenic heat in the heart. remove irritated." " medicine class on the analogy of natural things " cloud: " control the heart regretful Nang of palpus and insomnia." the modern study Fructus Gardeniae mainly contains compositions such as flavonoid gardenin.Pharmacological action: calmness, blood pressure lowering, function of gallbladder promoting, effect such as antibacterial are arranged.
Radix Glycyrrhizae: nature and flavor are sweet flat.Nontoxic.Go into spleen, stomach, lung meridian.Function and middle emergency, lung moistening, detoxifcation, coordinating the actions of various ingredients in a prescription.Process with the weakness of the spleen and stomach of living lack of appetite, stomachache, loose stool, overstrain heating cardiopalmus, cough etc." Japan hanako materia medica " day: " the peace soul is decided soul. mend five kinds of strain and seven kinds of impairment. and all are deficient, palpitation with fear, unhappiness, forgetful." " book on Chinese herbal medicine is just " cloud: " and Radix Glycyrrhizae. flavor is to sweet, the property that must neutralize. the merit of transferring benefit is arranged, thus poison get separate its poison.Its property of firm desirable sum. what medicine administered to bring out the cold got helps outside it, put in poison slow its speed." " medicine justice " say: " Radix Glycyrrhizae gives birth to the pathogenic fire purging with cold ..., process invigorating middle warmer with temperature ..." modern study: contain glycyrrhizic acid, enoxolone, glycyrrhizin etc.Pharmacological action has: the effect of adrenal cortex sample, antiinflammatory, anti-allergy action.Digestive tract is had spasmolytic, suppresses ulcer, influence effects such as gastric acid secretion, other has effects such as detoxifcation, antitussive, pain relieving.
The analysis of principles of formulating prescriptions the other side's justice of pressing monarch is as follows:
Semen Ziziphi Spinosae (parched) in the present invention's prescription, sweet in the mouth, property is flat, GUIXIN, liver, spleen, gallbladder meridian, merit are arrogated to oneself the liver benefiting blood, the moon that nourishes heart, mind tranquilizing and the heart calming, " medicine justice " day: " Semen Ziziphi Spinosae is outside the core master; skin benefit painstaking effort, and its gas is fried fragrant, turns to tepor, and mat is kind with the saturating motive, warm to help the mind.The bitter blood trouble of all will is decreased refreshingly with intelligence, cause the deficiency of having a guilty conscience, and spirit is lost peaceful, the palpitation with fear palpitation with a distress feeling, in a trance poor memory, the sweating due to debility excessive thirst, work as and must use.Get fragrant temperature again, with warming the liver, gallbladder, the empty insufficiency of blood of gall bladder, dysphoria and insomnia makes liver, gallbladder hemapodium with this, then the five internal organs peace and, doss rather." visible Semen Ziziphi Spinosae is the main force of this side's mind tranquilizing and the heart calming, the consumption in the side is 1.5 times of ministerial drug, 3 times of adjuvant.Amount gravity is specially so be the monarch drug of full side.Caulis Polygoni Multiflori, Radix Polygalae two flavors, equal popular feeling warp, the mind calming sedate is calmed the nerves, the merit of principal drug assistance tranquilizing by nourishing the heart, it is a ministerial drug.Fu Ling, Massa Medicata Fermentata, Radix Glycyrrhizae invigorating spleen to remove dampness, the stomach function regulating that helps digestion can make phlegm-damp remove, gastric qi and falling.Assistant helps the monarch and his subjects to treat disorder of stomach-QI, and dyspepsia is stagnated, and phlegm-damp is held back the card of being insomnia due to Jiao in the resistance.The Radix Salviae Miltiorrhizae treating blood disorders, the heat in purifying the blood is separated the agitation of heart-fire.The power of assistant monarch-minister drug nourishing blood to tranquillize the mind.The Fructus Gardeniae bitter cold, the pathogenic fire of be good at disappearing removing pathogen in the heart, lung, stomach warp and relieving restlessness, assistant helps monarch, minister treatment pathogenic heat to violate, or waste heat due to clearly must not crouch pacify.Poria, Massa Medicata Fermentata, Radix Glycyrrhizae, Radix Salviae Miltiorrhizae, the Fructus Gardeniae five tastes are adjuvant altogether.
Make a general survey of full side, reinforcement and elimination in combination, deficiency and excess is also controlled.The effect that mainly has tranquilizing by nourishing the heart has invigorating the spleen and regulating the stomach simultaneously concurrently, the power of clearing heat and relieving fidgetness.The clinical practice several years, to blood deficiency, resistance is empty, and diseases such as neurasthenia due to the disorder of stomach-QI, hyperactivity of hesrt-fire and liver-fire etc., palpitation with fear are forgetful, dreaminess insomnia, calentura agitation, malaise have good result.
Embodiment 1:
A kind of Chinese medicine with tranquilizing by nourishing the heart, wherein the weight proportion of each raw material is:
Semen Ziziphi Spinosae 250g Caulis Polygoni Multiflori 167g Radix Polygalae 167g Poria 167g
Radix Salviae Miltiorrhizae 83g Fructus Gardeniae 83g Massa Medicata Fermentata 83g Radix Glycyrrhizae 83g
A kind of preparation method of Chinese medicine with tranquilizing by nourishing the heart, described dosage form are that the processing step of preparation method of tablet is as follows:
(1), with after the Semen Ziziphi Spinosae parch, standby;
(2), Radix Glycyrrhizae, Massa Medicata Fermentata mixed powder be broken into fine powder after, standby;
(3), the Semen Ziziphi Spinosae Six-element Chinese medicine of Caulis Polygoni Multiflori, Radix Polygalae, Poria, Radix Salviae Miltiorrhizae, Fructus Gardeniae and step (1) preparation is decocted with water 2 times, for the first time add 12 times of water gagings, soaked 30 minutes, decocted 3 hours; For the second time add 10 times of water gagings, decocted 2 hours; Merge 2 times decoction liquor, filter, filtrate decompression is concentrated into when 60 ℃ of heat are surveyed, and relative density is 1.38 clear paste;
(4), add Radix Glycyrrhizae, Massa Medicata Fermentata fine powder and an amount of dextrin of step (2) preparation, mix and contain even system soft material, 14 mesh sieves are granulated, 60 ℃ of dryings, 12 mesh sieve granulate add 0.5% magnesium stearate, compacting in flakes, sugar coating promptly gets 1000.
Embodiment 2:
A kind of Chinese medicine with tranquilizing by nourishing the heart, it is the medicament that is prepared into by the following weight proportion raw material:
Semen Ziziphi Spinosae 190g Caulis Polygoni Multiflori 127g Radix Polygalae 127g Poria 12g
Radix Salviae Miltiorrhizae 63g Fructus Gardeniae 63g Massa Medicata Fermentata 63g Radix Glycyrrhizae 63g
Above-mentioned dosage form is that the preparation method of tablet is identical with embodiment 1.
Embodiment 3:
Semen Ziziphi Spinosae 310g Caulis Polygoni Multiflori 207g Radix Polygalae 207g Poria 207g
Radix Salviae Miltiorrhizae 103g Fructus Gardeniae 103g Massa Medicata Fermentata 103g Radix Glycyrrhizae 103g
Above-mentioned dosage form is that the preparation method of tablet is identical with embodiment 1.
Effect experiment of the present invention is reported as follows:
Summary: gastric infusion of the present invention can significantly reduce white mice spontaneous activity number of times, significant prolongation amobarbital sodium length of one's sleep.This medicine can significantly reduce mouse memory and reproduce the obstacle errors number.Show that the mind rather has the effect of calmness, hypnosis raising ability of learning and memory.
Experiment material:
Animal: Kunming kind white mice body weight 18-22g is provided by The Fourth Military Medical University's animal center, the animal quality certification number: the moving card of doctor word 08-013 number.
Medicine: Chinese medicinal tablet of the present invention, Yan'an pharmaceutical factory produces, lot number 950308.Every 0.25g, 80 every bottle, it is standby that the desaccharide clothing is made into 15% suspension with distilled water.
Scopolamine hydrobromide injection: Tian Feng pharmaceutical factory in Shanghai produces, lot number 900602.
Instrument: XL-2 type photoelectricity spontaneous activity in mice monitor, diving tower instrument.
Experimental technique and result:
1, Chinese medicinal tablet of the present invention is to the influence of spontaneous activity in mice
Get 50 of Kunming mouses, male and female half and half, be divided into 5 groups at random, ig gives Chinese medicinal tablet 3.0g/kg of the present invention, 1.0g/kg respectively, 0.33g/kg, chlorpromazine 0.01g/kg and ordinary water, 30min behind the filling stomach is put in each group mice in the spontaneous activity monitor respectively, survey spontaneous activity number of times in each Mus 3min, the results are shown in Table 1:
Table 1 mind is rather to the influence of spontaneous activity in mice
| Group | Dosage (g/kg) | Number of animals (only) | X ± S (inferior) is counted in spontaneous activity in the 3min |
| This Chinese medicinal tablet of this Chinese medicinal tablet of this Chinese medicinal tablet of matched group group group group chlorpromazine group | 0.33 1.00 3.00 0.01 | 10 10 10 10 10 | 32.3±8.5 30.7±4.8 24.8±5.6* 24.1±7.6* 13.1±5.4** |
Annotate: carry out the t check between group, with matched group than * p＜0.05, * * p＜0.01
As can be seen from Table 1, this Chinese medicine can significantly reduce the spontaneous activity in mice number of times, and big or middle dosage p＜0.05
2, this Chinese medicinal tablet is to the amobarbital sodium influence of the length of one's sleep
Get 40 of Kunming mouses, male and female half and half, body weight 23 ± 2.0g is divided into 4 groups at random, ig gives the mind peaceful 3g/kg respectively, 1.0g/kg, chlorpromazine 0.01g/kg, and equal-volume ordinary water, behind the administration 30min, each Mus is lumbar injection amobarbital sodium 20mg/kg respectively, writes down each Mus time for falling asleep and sleep time, the results are shown in Table 2:
This Chinese medicinal tablet of table 2 is to the amobarbital sodium influence of the length of one's sleep
| Group | Dosage (g/kg) | Number of animals (only) | Time for falling asleep X ± S min | The length of one's sleep X ± S min |
| This Chinese medicinal tablet of this Chinese medicinal tablet of matched group group group chlorpromazine group | 3.0 1.0 0.01 | 10 10 10 10 | 5.1±2.3 6.2±1.8 5.0±0.9 4.0±1.1 | 26.2±1 3.8 48.9±27.5* 40.5±21.2* 119.1±27.7** |
Annotate: carry out the t check between group, with matched group than * p＜0.05, * * p＜0.01
As can be seen from Table 2, the mind would rather prolong mouse sleep time.And 3g/kg, 1g/kg have significant difference (p＜0.05), but the mind does not rather have obvious influence to the mice time for falling asleep.
3, this Chinese medicinal tablet is to the influence of ability of learning and memory in mice
1) to the influence of memory acquisition disturbance ability of learning and memory in mice
Kunming mouse male and female half and half, body weight 18-22g is divided into 5 groups at random,, ig gives all to give the mind peaceful 3.0g/kg respectively, 1.0kg, 0.33g/kg, piracetam 0.36g/kg and ordinary water, continuous 7 days.After the administration in the 7th day, each group is lumbar injection hydrogen Australia acid scopolamine 2mg/kg respectively, behind the 10min, respectively each group mice is placed the diving tower instrument, be familiar with 3min after, logical 36V electricity is trained 5min on the electric grid, behind the 8th day administration 30min, respectively each Mus is put on the diving tower instrument.Energising is wrong reaction with mice biped electric shock grid, and the errors number of mice in the record 5min the results are shown in Table 3:
This Chinese medicine of table 3 is to the influence of memory acquisition disturbance ability of learning and memory in mice
| Group | Dosage (g/kg) | Number of animals (only) | Errors number X ± S (inferior) |
| This Chinese medicinal tablet of this Chinese medicinal tablet of this Chinese medicinal tablet of matched group group group group piracetam group | 3.0 1.0 0.33 0.36 | 14 11 13 14 12 | 1.23±1.17 0.82±0.87 0.46±0.66* 0.64±0.50 0.92±0.99 |
Annotate: carry out the t check between group, with matched group than * p＜0.05
Table 3 as can be seen, this Chinese medicinal tablet can reduce the errors number of memory acquisition disturbance mice, and during 1.0g/kg and matched group significant difference (p＜0.05) is relatively arranged.
2) to the influence of memory represents obstacle ability of learning and memory in mice
Kunming mouse, male and female half and half, body weight 1$-22g is divided into 6 groups at random, all gives the mind peaceful 3.0g/kg respectively, 1.0g/kg, 0.33g/kg piracetam 0.36g/kg and ordinary water, continuous 7 days.Place the diving tower instrument to be familiar with 3min mice after the administration in the 7th day, energising training 5min, 30min after the administration in the 8th day, except that the blank group, all the other respectively organize mice respectively ig give 40% ethanol 0.1ml/10g, 30min is placed on the diving tower of diving tower instrument, the energising, write down each errors number in each Mus 5min, the results are shown in Table 4:
This Chinese medicinal tablet of table 4 influences memory represents obstacle ability of learning and memory in mice
| Group | Dosage (g/kg) | Number of animals (only) | Errors number X ± S (inferior) |
| Blank this Chinese medicinal tablet of this Chinese medicinal tablet of this Chinese medicinal tablet of model group group group group piracetam group of dying | 3.0 1.0 0.33 0.36 | 11 9 11 11 14 12 | 0.36±0.50 1.78±1.39 0.45±0.52 0.36±0.50 0.64±0.63 0.50±0.52 |
Annotate: carry out the t check between group, with model group than * p＜0.01
As can be seen from Table 4, each organizes the errors number (p＜0.01) that the mind would rather significantly reduce memory represents obstacle mice.
Conclusion:
By above experimental result as can be seen, this Chinese medicine can reduce the spontaneous activity in mice number of times, prolong amobarbital sodium length of one's sleep, reduce the errors number of memory acquisition disturbance and memory represents obstacle mice, show that the mind rather has the calm ability that improves learning and memory.
The acute toxic reaction of the present invention after observing the mice administration, its conclusion (of pressure testing) is as follows: the peaceful sheet maximum tolerated dose of the mind of mouse stomach administration is a 36g/kg medicated powder, is equivalent to 280 times of clinical people's consumptions.
The present invention is through observing continuous repeat administration to the issuable toxic reaction of rat; Its conclusion (of pressure testing) is as follows: this Chinese medicine is with 8g/kg, 4g/kg, continuous one month of three kinds of dosage gastric infusions of 2g/kg, not influencing rat body weight increases, animal generally in order, hematology, biochemical, each organ coefficient no abnormality seen variation, the main organs tissue morphology is normal, and the rat long term toxicity test is not found toxic reaction and retardance toxic reaction.
Claims (4)
1, a kind of Chinese medicine with tranquilizing by nourishing the heart is characterized in that it is the medicament that is prepared into by the following weight proportion raw material:
127～207 parts in 127～207 parts of Poria of 127～207 parts of Radix Polygalaes of 190～310 parts of Caulis Polygoni Multiflori of Semen Ziziphi Spinosae
63～103 parts in 63～103 portions of Radix Glycyrrhizaes of 63～103 parts of Massa Medicata Fermentata of 63～103 portions of Fructus Gardeniaes of Radix Salviae Miltiorrhizae
2, a kind of Chinese medicine with tranquilizing by nourishing the heart as claimed in claim 1 is characterized in that wherein the weight proportion of each raw material is:
147～187 parts in 147～187 parts of Poria of 147～187 parts of Radix Polygalaes of 220～280 parts of Caulis Polygoni Multiflori of Semen Ziziphi Spinosae
73～93 parts in 73～93 portions of Radix Glycyrrhizaes of 73～93 parts of Massa Medicata Fermentata of 73～93 portions of Fructus Gardeniaes of Radix Salviae Miltiorrhizae
3, a kind of Chinese medicine with tranquilizing by nourishing the heart as claimed in claim 1 is characterized in that wherein the weight proportion of each raw material is:
167 parts in 167 parts of Poria of 167 parts of Radix Polygalaes of 250 parts of Caulis Polygoni Multiflori of Semen Ziziphi Spinosae
83 parts in 83 portions of Radix Glycyrrhizaes of 83 parts of Massa Medicata Fermentata of 83 portions of Fructus Gardeniaes of Radix Salviae Miltiorrhizae
4, according to claim 1,2 or 3 described a kind of preparation method of Chinese medicine with tranquilizing by nourishing the heart, it is characterized in that: described dosage form is that the processing step of preparation method of tablet is as follows:
(1), with after the Semen Ziziphi Spinosae parch, standby;
(2), Radix Glycyrrhizae, Massa Medicata Fermentata mixed powder be broken into fine powder after, standby;
(3), the Semen Ziziphi Spinosae Six-element Chinese medicine of Caulis Polygoni Multiflori, Radix Polygalae, Poria, Radix Salviae Miltiorrhizae, Fructus Gardeniae and step (1) preparation is decocted with water 2 times, for the first time add 12 times of water gagings, soaked 30 minutes, decocted 3 hours; For the second time add 10 times of water gagings, decocted 2 hours; Merge 2 times decoction liquor, filter, filtrate decompression is concentrated into when 60 ℃ of heat are surveyed, and relative density is 1.38 clear paste;
(4), add Radix Glycyrrhizae, Massa Medicata Fermentata fine powder and an amount of dextrin of step (2) preparation, mix and contain even system soft material, 14 mesh sieves are granulated, 60 ℃ of dryings, 12 mesh sieve granulate add 0.5% magnesium stearate, compacting in flakes, sugar coating, promptly.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102302657A (en) * | 2011-09-08 | 2012-01-04 | 孙跃春 | Preparation for improving brain fatigue and preparation method thereof |
| CN103417808A (en) * | 2013-08-14 | 2013-12-04 | 北京农学院 | Sedative traditional Chinese medicine veterinary drug |
| CN104474375A (en) * | 2014-12-11 | 2015-04-01 | 丁大双 | Traditional Chinese medicine for treating insomnia |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1232698A (en) * | 1999-03-09 | 1999-10-27 | 李胤良 | Health beverage capable of tranquilizing through nourishing the heart |
| CN100381165C (en) * | 2003-12-31 | 2008-04-16 | 赵恒� | Medication for improving sleep |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102302657A (en) * | 2011-09-08 | 2012-01-04 | 孙跃春 | Preparation for improving brain fatigue and preparation method thereof |
| CN103417808A (en) * | 2013-08-14 | 2013-12-04 | 北京农学院 | Sedative traditional Chinese medicine veterinary drug |
| CN104474375A (en) * | 2014-12-11 | 2015-04-01 | 丁大双 | Traditional Chinese medicine for treating insomnia |
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