CN1852687B - 控释组合物的制备方法 - Google Patents

控释组合物的制备方法 Download PDF

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Publication number
CN1852687B
CN1852687B CN200480026606.7A CN200480026606A CN1852687B CN 1852687 B CN1852687 B CN 1852687B CN 200480026606 A CN200480026606 A CN 200480026606A CN 1852687 B CN1852687 B CN 1852687B
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CN
China
Prior art keywords
organic
acid
polymer
water
octreotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200480026606.7A
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English (en)
Chinese (zh)
Other versions
CN1852687A (zh
Inventor
P·库克·盖瑞
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brooke Wood Pharmaceuticals Ltd
Evonik Corp
Original Assignee
Evonik Corp
PR Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Corp, PR Pharmaceuticals Inc filed Critical Evonik Corp
Publication of CN1852687A publication Critical patent/CN1852687A/zh
Application granted granted Critical
Publication of CN1852687B publication Critical patent/CN1852687B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN200480026606.7A 2003-07-15 2004-07-15 控释组合物的制备方法 Expired - Fee Related CN1852687B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48766303P 2003-07-15 2003-07-15
US60/487,663 2003-07-15
PCT/US2004/022816 WO2005009356A2 (en) 2003-07-15 2004-07-15 Method for the preparation of controlled release formulations

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2012104691508A Division CN102935069A (zh) 2003-07-15 2004-07-15 控释组合物的制备方法

Publications (2)

Publication Number Publication Date
CN1852687A CN1852687A (zh) 2006-10-25
CN1852687B true CN1852687B (zh) 2014-01-22

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN200480026606.7A Expired - Fee Related CN1852687B (zh) 2003-07-15 2004-07-15 控释组合物的制备方法
CN2012104691508A Pending CN102935069A (zh) 2003-07-15 2004-07-15 控释组合物的制备方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2012104691508A Pending CN102935069A (zh) 2003-07-15 2004-07-15 控释组合物的制备方法

Country Status (9)

Country Link
US (1) US8871269B2 (cg-RX-API-DMAC7.html)
EP (2) EP1651136B1 (cg-RX-API-DMAC7.html)
JP (2) JP5165239B2 (cg-RX-API-DMAC7.html)
CN (2) CN1852687B (cg-RX-API-DMAC7.html)
AU (1) AU2004259208B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0412059A (cg-RX-API-DMAC7.html)
CA (1) CA2532302C (cg-RX-API-DMAC7.html)
ES (1) ES2625343T3 (cg-RX-API-DMAC7.html)
WO (1) WO2005009356A2 (cg-RX-API-DMAC7.html)

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WO2005009356A2 (en) 2003-07-15 2005-02-03 Pr Pharmaceuticals, Inc. Method for the preparation of controlled release formulations
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EP2444069B1 (en) * 2003-07-23 2019-06-05 Evonik Corporation Controlled release compositions
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KR101913102B1 (ko) * 2010-03-11 2018-10-31 와이어쓰 엘엘씨 메틸날트렉손의 경구 제형 및 친유성 염
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TWI501781B (zh) * 2010-12-10 2015-10-01 Ind Tech Res Inst 可控制釋放的組合物及其製造方法
US20160151511A1 (en) * 2014-12-02 2016-06-02 Antriabio, Inc. Proteins and protein conjugates with increased hydrophobicity
US20190224275A1 (en) 2017-05-12 2019-07-25 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis
US20190117573A1 (en) * 2017-10-19 2019-04-25 Hyalo Technologies, LLC Composition and method of preparation of risperidone extended release preparation
US20230062487A1 (en) * 2020-01-24 2023-03-02 W. L. Gore & Associates, Inc. Sustained-release matrices for adventitial or periadventitial neural ablation and uses thereof
CN111643483B (zh) * 2020-07-06 2022-03-29 济南大学 一种用于制备加兰他敏缓释微球的方法
US11992559B2 (en) 2021-02-24 2024-05-28 Oakwood Laboratories, Llc Microsphere formulations comprising lurasidone and methods for making and using the same
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Also Published As

Publication number Publication date
US8871269B2 (en) 2014-10-28
EP1651136B1 (en) 2017-03-08
EP2462896A1 (en) 2012-06-13
US20060228414A1 (en) 2006-10-12
BRPI0412059A (pt) 2006-09-05
EP1651136A2 (en) 2006-05-03
JP2011144207A (ja) 2011-07-28
CN1852687A (zh) 2006-10-25
JP5165239B2 (ja) 2013-03-21
CN102935069A (zh) 2013-02-20
WO2005009356A2 (en) 2005-02-03
AU2004259208A1 (en) 2005-02-03
WO2005009356A3 (en) 2005-06-09
CA2532302A1 (en) 2005-02-03
ES2625343T3 (es) 2017-07-19
JP2007524645A (ja) 2007-08-30
EP1651136A4 (en) 2009-07-08
CA2532302C (en) 2016-12-20
AU2004259208B2 (en) 2011-04-28

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Granted publication date: 20140122

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