CN1846755A

CN1846755A - Chinese medicine for treating bronchial asthma in acute attack stage and its prepn process

Info

Publication number: CN1846755A
Application number: CN 200510041957
Authority: CN
Inventors: 郝朝军
Original assignee: TIANLUTANG PHARMACEUTICAL CO Ltd SHAANXI
Current assignee: Shaanxi Kanghui Pharmaceutical Co Ltd
Priority date: 2005-04-15
Filing date: 2005-04-15
Publication date: 2006-10-18
Anticipated expiration: 2025-04-15
Also published as: CN100450514C

Abstract

The present invention is Chinese medicine for treating bronchial asthma in acute stage and its preparation process. The Chinese medicine is prepared with ephedra, skullcap root, almond, coltsfoot flower, pinellia tuber and other Chinese medicinal materials. It has the functions of ventilating the lung, relieving asthma, tonifying kidney and eliminating phlegm. It is used in treating bronchial asthma and has high effective rate.

Description

Chinese Traditional Medicines of treatment bronchial asthma in acute attack stage and preparation method thereof

One, technical field

The present invention relates to a kind of medicine for the treatment of bronchial asthma in acute attack stage, is the Chinese patent medicine of feedstock production with the Chinese herbal medicine specifically, the invention still further relates to the preparation method of this medicine.

Two, background technology

Bronchial asthma is that a kind of airway allergy inflammation and airway hyperreactivity based on eosinophilic granulocyte, mastocyte reaction is the disease of feature.The susceptible person shows as in various degree reversibility airway obstruction symptom to this type of inflammation.

After having the people of allergic constitution to contact antigen, make smooth muscle that spasm take place immediately, this is that speed is sent out the property asthma reaction.More commonly many patients start at contact antigen a few hours and even several 10 hours rear and make asthma, are called late asthmatic response, and this is the result of airway allergy inflammation.During air flue myxedema, inflammatory cell infiltration, glandular secretion increase, the mucociliary clearance dysfunction, add in the tube chamber that it also is the important mechanisms of asthma attack that mucous plug blocks.

Bronchial asthma belongs to traditional Chinese medical science heavy breathing disease category, is a kind of common, multiple respiratory tract disease, have repeatedly to show effect, delay the difficult characteristics that heal, and be a kind of principal disease of serious threat public health in the world wide.Doctor trained in Western medicine thinks that bronchial asthma is a kind of air flue chronic nonspecific inflammation disease, mainly takes (one) aspect preventing and treating, eliminates the cause of disease: should avoid or eliminate allergen and other nonspecific stimulations that cause asthma attack, remove various risk factors.(2), control acute attack: should take into account spasmolytic, antiinflammatory, removal air flue mucous plug during asthma attack, keep respiratory passage unblocked, prevent secondary infection.Its medication is: 1, adrenomimetic drug medicine; 2, theophylline (xanthine) class medicine; 3, calcium antagonist; 4, adrenal gland's glucocorticoid etc.Along with the continuous increase of types of drugs, its side effects of pharmaceutical drugs are also increasing, but its late result is not good enough, and are particularly undesirable to the therapeutic effect of acute bronchial asthma.Relevant by retrieval documents and materials do not find that related to the present invention or similar medicine had the publicity report.

Three, summary of the invention

The object of the present invention is to provide a kind of preparation method of Chinese Traditional Medicines of treatment bronchial asthma in acute attack stage of pure Chinese prescription.

Chinese medical theory thinks that asthma is a kind of ictal rale asthma illness, and its pathological factor is based on expectorant.The not outer lung of the generation of expectorant can not spreading body fluid, and spleen can not transfer body fluid, kidney can not evaporate water liquid, is condensed into expectorant with the bringing about the spread of body fluid, and volt is hidden in lung, becomes " long-standing " of morbidity.Asthma many chance because of " latent phlegm " of stage of attack felt priming, phlegm rising following QI, and obstruction of QI due to retention of phlegm, the knot of fighting mutually, the air flue that is jammed, impairment of dispersing and descending function of the lung, and cause ring as shout the breath dyspnea with rapid and short breath.Asthma divides stage of attack and catabasis, is generally " take stopgap measures when sending out, effect a permanent cure at ordinary times ".If the asthma stage of attack, is sick affection of cold, or innate deficiency of YANG in the body, and expectorant belongs to cold-phlegm and is asthma of cold-type for suffering from, then sending out from cold transformation.The cause of disease is in heat, or innate excess of YANG in the body, and expectorant belongs to heat-phlegm for suffering from from transconversion into heat, then shows as asthma of heat type.Strongly fragrant and heat-transformation person in the asthma of cold-type patient cold-phlegm is also arranged, or the asthma of heat type patient, accumulation of phlegm-heat in the interior and be the exterior tightened by pathogenic windcold person, the genus syndrome of superficies cold and interior heat also is clinical common card marquis.The most course of disease of asthma is longer again, and as outbreak repeatedly, the cloudy consume of gas due to the impairment of purifying and descending function of the lung, is again failure of the kidney in receiving QI, and gas does not return unit to do, and forms deficiency in origin and excess in superficiality, the pathological characters of upper excess and lower deficiency.If evil few void is many, lung kidney two loses, and the turbid heap soil or fertilizer over and around the roots of expectorant is contained, even collapse syndrome caused by dyspnea danger marquis occurs.According to the asthma These characteristics of stage of attack, should be with treating both the principal and the secondary aspects of a disease at the same time, cold and heat and asthenia and sthenia is taken into account and is its rule of treatment, the lung qi dispersing Dingchuan, eliminating phlegm and lowering adverse QI, invigorating kidney qi are its method of treatment.

The object of the present invention is achieved like this: it is the medicament of being made by the following weight proportion raw material:

375 parts of 450 portions of Flos Farfaraees of 525 portions of Semen Armeniacae Amarums of 300 parts of Radix Scutellariaes of Herba Ephedrae

600 parts of 150 parts of Fructus Lycii of 150 portions of Radix Glycyrrhizaes of 450 portions of Cortex Cinnamomis of Rhizoma Pinelliae Preparatum

The Chinese Traditional Medicines of treatment bronchial asthma in acute attack stage of the present invention are a kind of granules.

The preparation method of the Chinese Traditional Medicines of treatment bronchial asthma in acute attack stage of the present invention, its preparation method is: get Herba Ephedrae, Semen Armeniacae Amarum, Cortex Cinnamomi, Rhizoma Pinelliae Preparatum with an amount of dipping of 95% medicinal alcohol 24 hours, filter filtrate for later use.Medicinal residues and Flos Farfarae, Radix Scutellariae, Radix Glycyrrhizae, Fructus Lycii decoct with water secondary, and decocting time was respectively 1.5 hours, 1 hour, merging filtrate, filter, be concentrated into about 70 ℃ of relative density, spray drying gets dry extract, add an amount of lactose, with alcohol dipping liquid is wetting agent, granulates drying, make 1000 parts, be distributed into every bag of 3g.

Optimum implementation of the present invention:

Herba Ephedrae 300g Radix Scutellariae 525g Semen Armeniacae Amarum 450g Flos Farfarae 375g

Rhizoma Pinelliae Preparatum 450g Cortex Cinnamomi 150g Radix Glycyrrhizae 150g Fructus Lycii 600g

Its preparation method is: get Herba Ephedrae, Semen Armeniacae Amarum, Cortex Cinnamomi, Rhizoma Pinelliae Preparatum with an amount of dipping of 95% medicinal alcohol 24 hours, filter filtrate for later use.Medicinal residues and Flos Farfarae, Radix Scutellariae, Radix Glycyrrhizae, Fructus Lycii decoct with water secondary, and decocting time was respectively 1.5 hours, 1 hour, merging filtrate, filter, be concentrated into about 70 ℃ of relative density, spray drying gets dry extract, add an amount of lactose, with alcohol dipping liquid is wetting agent, granulates drying, make 1000g, every bag of 3g.When the patient uses, four times a day, each one bag.

The Chinese Traditional Medicines of treatment bronchial asthma in acute attack stage provided by the invention, its medicament composing prescription epheday intermedia, hot, little hardship, temperature.Function: lung qi dispersing cold expelling Dingchuan.The hot hardship of loosing of this product is let out, and Wen Tongxuan is smooth, the external enwergy dispersing wind-cold, and the internal energy lung qi dispersing gas of opening has good depressed lung-energy dispersing effect, is the key medicine of relievining asthma.Radix Scutellariae, its nature and flavor hardship, cold.Heat clearing and damp drying, eliminating fire and detoxication, eliminating heat from the lung is arranged preferably and reduce phlegm, cough-relieving, the effect of relievining asthma.Diseases such as the clinical lung-heat that is used for is stopped up and to be held back, and cough with asthma, the expectorant due to the impairment of purifying function of the lung is thick.Modern pharmacological research also confirms its contained baicalin, baicaligenin is shunk by guinea-pig isolated trachea anaphylaxis and the whole animal allergic asthma all has mitigation, with ephedrine synergism is arranged.The cold Wen Xiangwu of Herba Ephedrae, Radix Scutellariae two medicines, both lung qi dispersing expelling cold pathogen and lowering adverse QI, the removing heat-phlegm Dingchuan is very suitable to syndrome of superficies cold and interior heat again, is monarch drug in the side.Flos Farfarae, hot, warm, nourishing the lung to keep the adverse QI downward, relieving cough and resolving phlegm is because its profit warm in nature has preventing phlegm from forming and stopping coughing preferably, the lowering the adverse-rising QI to subdue asthma effect.Semen Armeniacae Amarum, hardship, tepor, bitter drop-down gas, relieving cough and asthma.Rhizoma Pinelliae Preparatum, hot, warm, drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, distinguished to the cough with dyspnea curative effect that not removing dampness of spleen, sputum are stopped up due to stagnating.Flos Farfarae, Semen Armeniacae Amarum, Rhizoma Pinelliae Preparatum three medicines are worked in coordination with, altogether ministerial drug in the principal drug assistance eliminating phlegm and lowering adverse QI side of being.Cortex Cinnamomi, hot, sweet, big heat.Warming and recuperating the kidney-YANG, boosting source of fire for eliminating abundance of yin, warm nutrient blood and sharp blood vessels.Cortex Cinnamomi both the kidney warming sun in the side, again by its promoting blood circulation, logical hundred medicines of a surname and inspire yang-energy rouse oneself kidney yang, and gas is root to some extent, returns unit to reach improving inspiration by invigorating kidney-QI, the effect of dyspnea self-balancing.Fructus Lycii, sweet, flat.Invigorating the liver and kidney is deficient, benefiting essence-blood is not enough.Match with Cortex Cinnamomi, negative and positive are held concurrently mutually, and both improving inspiration by invigorating the kidney controls that it is basic, can make the Cortex Cinnamomi temperature again and not dry.Two medicines are adjuvant drug in the side of being altogether.Radix Glycyrrhizae, sweet, flat, be its expelling phlegm for arresting cough effect of performance at Fang Zhongyi, with assistant monarch drug preventing phlegm from forming and stopping coughing Dingchuan, the 2nd, relax the property of medicine, coordinating the actions of various ingredients in a prescription, be messenger drug in the side.

Take a broad view of full side, monarch, compatibility is proper, at the pathological characters of the clinical manifestation of asthma stage of attack syndrome of superficies cold and interior heat and deficiency in origin and excess in superficiality, upper excess and lower deficiency, with the lung qi dispersing Dingchuan, eliminating phlegm and lowering adverse QI is main, the lung qi that falls superinverse is held concurrently with invigorating kidney qi to control its mark, mends the Zhi Qiben that is not enough to of following unit, so treating both the principal and secondary aspects of a disease is evident in efficacy.

The Chinese Traditional Medicines of treatment bronchial asthma in acute attack stage provided by the invention have following pharmacological action: the effect of (1) relieving cough and reducing sputum.Guinea pig cough due to ammonia induced mice cough and the citric acid all there is tangible antitussive effect, can reduces the phenol red excretion amount of mice trachea.(2) antiasthmatic effect.The Cavia porcellus asthma attack incubation period due to histamine and the acetylcholine mixed liquor can be obviously prolonged, and the guinea pig tracheal smooth muscle tension force that exsomatizes can be reduced.(3) antiinflammatory action.Can suppress that acetic acid induced mice abdominal cavity capillary permeability increases and histamine induced mice capillary of skin permeability increases, foot swelling also has obvious inhibitory action to rat Ovum Gallus domesticus album.(4) enhancing body anti-stress ability.Can obviously prolong swimming time and the life span of animal under cold environment of " yang deficiency " mice.(5) adrenal cortex reinforcing systemic-function.To hydrocortisone induced mice weight loss, atrophy of adrenal gland and serum cortisol content reduce.(6) immunological enhancement: can obviously alleviate the immune organ thymus of " yang deficiency " animal and the atrophy of spleen.For the mice of immunologic hypofunction, can significantly strengthen the non-special phagocytic function and the delayed skin hypersensitivity (cellular immune function) of its mononuclear phagocyte.(7) antibacterial action.Respiratory tract common pathogen and conditioned pathogen all there is certain inhibitory action.(8) anti-allergic effects.The models of passive skin irritability of rats reaction can be obviously suppressed, and the rat abdominal cavity mast cell degranulation can be suppressed.

The Chinese Traditional Medicines of treatment bronchial asthma in acute attack stage provided by the invention have the lung qi dispersing Dingchuan, and kidney tonifying eliminates the phlegm.Be used for the bronchial asthma in acute attack stage syndrome of superficies cold and interior heat.Card is seen: rapid breathing, and wheezing in the larynx, fullness and distention in the chest and hypochondrium, cough with difficulty in expectoration, expectorant is told thickness, or sees cold physique, fever of the body, unhappiness, general pain, thirsty etc.Through clinical observation bronchial asthma Syndrome in TCM marquis's obvious effective rate and effective percentage is respectively 7222%, 8889%, obvious effective rate and effective percentage to the symptom of panting are respectively 7333%, 9111%, and the obvious effective rate and the effective percentage of wheezing sound is respectively 6778%, 8444%.

Claims

1, a kind of Chinese Traditional Medicines for the treatment of bronchial asthma in acute attack stage is characterized in that it is the medicament of being made by the following weight proportion raw material:

2, a kind of Chinese Traditional Medicines for the treatment of bronchial asthma in acute attack stage as claimed in claim 1 is characterized in that said medicament is a kind of granule.

3, as Chinese Traditional Medicines of claim 1,2 described treatment bronchial asthma in acute attack stage and preparation method thereof, it is characterized in that: get Herba Ephedrae, Semen Armeniacae Amarum, Cortex Cinnamomi, Rhizoma Pinelliae Preparatum with an amount of dipping of 95% medicinal alcohol 24 hours, filter filtrate for later use.Medicinal residues and Flos Farfarae, Radix Scutellariae, Radix Glycyrrhizae, Fructus Lycii decoct with water secondary, and decocting time was respectively 1.5 hours, 1 hour, merging filtrate, filter, be concentrated into about 70 ℃ of relative density, spray drying gets dry extract, add an amount of lactose, with alcohol dipping liquid is wetting agent, granulates drying, make 1000 parts, be distributed into every bag of 3g.