CN1840030A - Effervescence granule of beautyberry and preparation method thereof - Google Patents
Effervescence granule of beautyberry and preparation method thereof Download PDFInfo
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- CN1840030A CN1840030A CN 200610020140 CN200610020140A CN1840030A CN 1840030 A CN1840030 A CN 1840030A CN 200610020140 CN200610020140 CN 200610020140 CN 200610020140 A CN200610020140 A CN 200610020140A CN 1840030 A CN1840030 A CN 1840030A
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- beautyberry
- callicarpa nudiflora
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- effervescence
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Abstract
The invention relates to nudiflower beautyberry leaf effervescent granules and preparing process, wherein the granules are prepared from the raw materials (by weight percent) of nudiflower beautyberry leaf concrete powder 4-75%, auxiliary materials 25-96% through the steps of water extracting, concentrating, drying, palletizing, granulating, and split charging, the auxiliary materials include lactose, cane sugar, sodium hydrogen carbonate, Stevioside, fragrant citrus powder and sodium glutamate.
Description
Technical field
The present invention relates to a kind of antiinflammatory, detoxifcation, convergence, hemostatic Chinese patent medicine preparation and preparation method thereof, particularly a kind of absorptions soon, high, the excellent in taste of curative effect, take and carry effervescence granule of beautyberry and preparation method thereof more easily.
Background technology
Callicarpa nudiflora (Callicarpa nudiflora Hook.et Arn) is the Verenaceae medicinal plants, mildly bitter flavor, puckery, and property is flat.Antibacterial anti hemorrhagic is arranged, eliminating inflammation and expelling toxin, the function of dissipating blood stasis for subsidence of swelling.Because it has antibacterial bacteriostatic and hemostatic effect simultaneously, thereby the single medicinal material that often is reserved as hemostasis clinically and protects from infection.Its clinical efficacy is not seen the clinical report of toxic side effect certainly.The peroral dosage form that contains Callicarpa nudiflora that has gone on the market at present only has tablet, but it is full extractum sheet, exists disintegrate slow, and bioavailability is not high, especially all slower problem of drug absorption and produce effects.Therefore, the urgent need development is a kind of takes with splendid mouthfeel Instant Drinks under liquid condition by after the flavoring, enters digestive tract at once and absorbs the effervescent granule of quicker performance therapeutical effect.Still do not have at present report at home, therefore have very vast market prospect about research, production and the clinical use that contains the effervescence granule of beautyberry agent.
Summary of the invention
The present invention is intended to overcome the defective of traditional oral tablet, provide that a kind of therapeutical effect is strong, mouthfeel good, the patient has good compliance and easy to carry, the bioavailability height absorbs fast, quality controllable, effervescence granule of beautyberry that curative effect is high and preparation method thereof.
For achieving the above object, the technical solution used in the present invention is as follows:
A kind of effervescence granule of beautyberry is characterized in that it is that the preparation of raw material of pressing column weight amount percentage ratio forms: principal agent 4～75%, adjuvant 25～96%.
Described principal agent is for pressing the quantitative Callicarpa nudiflora water extraction of its weight dry extract.
Described adjuvant is added in the principal agent for pressing the row raw materials by weight percent:
A, lactose 0～30%
B sucrose 0～50%
B, sodium bicarbonate 1～25%
C, citric acid 1～25%
D, steviosin 0～5%
F, fragrant citrus powder 0.5～5%
G, sodium glutamate 0.1～2%
Wherein, lactose is good filler; Sodium bicarbonate, citric acid are respectively effervescive alkali source and acid source, make molten the loosing of the quick effervescent of medicine chance water; Steviosin is as sweeting agent; The fragrant citrus powder is as aromatic; Sodium glutamate is the correctives that improves the sense of taste.
The preparation method of described effervescence granule of beautyberry comprise to principal agent carries out water extraction, concentrates, dry, add operations such as granulation behind the adjuvant, mixing, granulate, packing again, its concrete processing step is as follows:
A, get the leaf of Callicarpa nudiflora, extracting in water twice, 1～3 hour for the first time, 1～3 hour for the second time, filter, merging filtrate is evaporated to relative density and is the extractum of 1.05～1.40 (80 ℃), and is standby;
B, get steps A gained Callicarpa nudiflora extractum, drying, pulverize the Callicarpa nudiflora dry extract;
C, get step B gained dry extract, add mix homogeneously behind the adjuvant by above-mentioned weight proportion, add an amount of dehydrated alcohol simultaneously again and granulate, 35～65 ℃ of cold drying get the dried granule of Callicarpa nudiflora;
Behind D, the dried granule granulate of Callicarpa nudiflora with step C, packing gets product.
The specification of described effervescence granule of beautyberry finished product is: every bag heavily is 1～25 gram.
The invention has the advantages that:
1, the present invention will need the pharmaceutical dosage form than large dose oral administration, make the effervescent granule form that is similar to the administration of Chinese medicine decoction, thereby improve cost performance and the therapeutic index of medicine on the therapeutics meaning greatly.
2, effervescence granule of beautyberry of the present invention need not be swallowed and adopt and drink, and need not patient's sheet of swallowing, thereby it is low and slow to have changed Chinese patent medicine oral formulations disintegration, absorbs the slow common fault that takes effect in the body.
3, effervescence granule of beautyberry of the present invention has excellent taste, and the patient easily accepts, and the bioavailability height absorbs soon, and is quality controllable, the advantage that curative effect is high.
The specific embodiment
Embodiment 1
A kind of effervescence granule of beautyberry is characterized in that it is to press column weight amount proportion raw material to be mixed with 1000g:
Callicarpa nudiflora dry extract 333.3 grams
Lactose 370 grams
Sodium bicarbonate 120 grams
Citric acid 150 grams
Fragrant citrus powder 10 grams
Steviosin 12 grams
Sodium glutamate 4.7 grams
Make 1000 grams altogether
The preparation method of effervescence granule of beautyberry of the present invention is as follows:
Get the Callicarpa nudiflora leaf, extracting in water twice, 2 hours for the first time, 1 hour for the second time, filter, merging filtrate, being evaporated to relative density is the extractum of 1.25～1.40 (80 ℃), dry, pulverizing makes the Callicarpa nudiflora dry extract, adds sodium bicarbonate, lactose, citric acid, steviosin, sodium glutamate, fragrant citrus powder, mix homogeneously, add an amount of dehydrated alcohol again and granulate 35～65 ℃ of cold drying; It heavily is the effervescence granule of beautyberry of 1 gram that granulate, packing promptly get every bag.The effervescent disintegrate in 5 minutes of gained granule becomes clear solutions, and granularity, moisture meet Chinese Pharmacopoeia version appendix in 2005 pertinent regulations, and every bag contains the Callicarpa nudiflora total flavones in anhydrous rutin, is no less than 150mg.
Embodiment 2
A kind of effervescence granule of beautyberry is characterized in that it is to press column weight amount proportion raw material to be mixed with 1000g:
Callicarpa nudiflora powder 500 grams
Lactose 367.5 grams
Sodium bicarbonate 50 grams
Citric acid 65 grams
Fragrant citrus powder 5 grams
Steviosin 10 grams
Sodium glutamate 2.5 grams
Make 1000 grams altogether
The preparation method of effervescence granule of beautyberry of the present invention is as follows:
Get the Callicarpa nudiflora leaf, extracting in water twice, 3 hours for the first time, 1 hour for the second time, filter, merging filtrate, being evaporated to relative density is the extractum of 1.35 (80 ℃), dry, pulverizing makes the Callicarpa nudiflora dry extract, adds sodium bicarbonate, lactose, citric acid, steviosin, sodium glutamate, fragrant citrus powder, mix homogeneously, add an amount of dehydrated alcohol again and granulate 35～50 ℃ of cold drying; It heavily is the effervescence granule of beautyberry of 1 gram that granulate, packing promptly get every bag.The effervescent disintegrate in 5 minutes of gained granule becomes clear solutions, and granularity, moisture meet Chinese Pharmacopoeia version appendix in 2005 pertinent regulations, and every bag contains the Callicarpa nudiflora total flavones in anhydrous rutin, is no less than 80mg.
Embodiment 3
A kind of effervescence granule of beautyberry is characterized in that it is to press column weight amount proportion raw material to be mixed with 1000g:
Callicarpa nudiflora powder 40 grams
Sucrose 720.5 grams
Sodium bicarbonate 100 grams
Citric acid 130 grams
Fragrant citrus powder 5 grams
Sodium glutamate 1.5 grams
Make 1000 grams altogether
The preparation method of effervescence granule of beautyberry of the present invention is as follows:
Get the Callicarpa nudiflora leaf, extracting in water twice, 1 hour for the first time, 1 hour for the second time, filter, merging filtrate, being evaporated to relative density is the extractum of 1.05～1.30 (80 ℃), dry, be ground into the Callicarpa nudiflora dry extract, add sodium bicarbonate, citric acid, sucrose, sodium glutamate, fragrant citrus powder, mix homogeneously, add an amount of dehydrated alcohol and granulate 50～65 ℃ of cold drying; It heavily is the effervescence granule of beautyberry of 25 grams that granulate, packing promptly get every bag.The effervescent disintegrate in 5 minutes of gained granule becomes clear solutions, and granularity, moisture meet Chinese Pharmacopoeia version appendix in 2005 pertinent regulations, and every bag contains the Callicarpa nudiflora total flavones in anhydrous rutin, is no less than 160mg.
Embodiment 4
A kind of effervescence granule of beautyberry is characterized in that it is to press column weight amount proportion raw material to be mixed with 1000g:
Callicarpa nudiflora powder 750 grams
Lactose 60 grams
Sodium bicarbonate 30 grams
Citric acid 40 grams
Fragrant citrus powder 50 grams
Steviosin 50 grams
Sodium glutamate 20 grams
Make 1000 grams altogether
The preparation method of effervescence granule of beautyberry of the present invention is as follows:
Get the Callicarpa nudiflora leaf, extracting in water twice, 2 hours for the first time, 3 hours for the second time, filter, merging filtrate, being evaporated to relative density is the extractum of 1.30 (80 ℃), dry, be ground into the Callicarpa nudiflora dry extract, add sodium bicarbonate, citric acid, sucrose, sodium glutamate, fragrant citrus powder, mix homogeneously, add an amount of dehydrated alcohol and granulate 40～60 ℃ of cold drying; It heavily is the effervescence granule of beautyberry of 1.3 grams that granulate, packing promptly get every bag.The effervescent disintegrate in 5 minutes of gained granule becomes clear solutions, and granularity, moisture meet Chinese Pharmacopoeia version appendix in 2005 pertinent regulations, and every bag contains the Callicarpa nudiflora total flavones in anhydrous rutin, is no less than 180mg.
Claims (4)
1, a kind of effervescence granule of beautyberry is characterized in that it is that the preparation of raw material of pressing column weight amount percentage ratio forms: principal agent 4～75%, adjuvant 25～96%
Described principal agent is for pressing the quantitative Callicarpa nudiflora water extraction of its weight dry extract;
Described adjuvant is pressed the row raw materials by weight percent and is added in the principal agent:
A, lactose 0～30%
B sucrose 0～50%
B, sodium bicarbonate 1～25%
C, citric acid 1～25%
D, steviosin 0～5%
F, fragrant citrus powder 0.5～5%
G, sodium glutamate 0.1～2%.
2, effervescence granule of beautyberry according to claim 1 is characterized in that it is to press column weight amount proportion raw material to be mixed with 1000g:
Callicarpa nudiflora dry extract 333.3 grams
Lactose 370 grams
Sodium bicarbonate 120 grams
Citric acid 150 grams
Fragrant citrus powder 10 grams
Steviosin 12 grams
Sodium glutamate 4.7 grams
3, the preparation method of effervescence granule of beautyberry according to claim 1 and 2, it is characterized in that comprising to principal agent carry out water extraction, concentrate, dry, add operations such as granulation behind the adjuvant, mixing, granulate, packing again, its concrete processing step is as follows:
A, get the leaf of Callicarpa nudiflora, extracting in water twice, 1～3 hour for the first time, 1～3 hour for the second time, filter, merging filtrate is evaporated to relative density and is 1.05～1.40 extractum, and is standby;
B, get steps A gained Callicarpa nudiflora extractum, drying, pulverize the Callicarpa nudiflora dry extract;
C, get step B gained dry extract, add mix homogeneously behind the adjuvant by above-mentioned weight proportion, add an amount of dehydrated alcohol simultaneously again and granulate, 35～65 ℃ of cold drying get the dried granule of Callicarpa nudiflora;
Behind D, the dried granule granulate of Callicarpa nudiflora with step C, packing gets product.
4, the preparation method of effervescence granule of beautyberry according to claim 3 is characterized in that the specification of described effervescence granule of beautyberry finished product is: every bag heavily is 1～25 gram.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610020140 CN1840030A (en) | 2006-01-12 | 2006-01-12 | Effervescence granule of beautyberry and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610020140 CN1840030A (en) | 2006-01-12 | 2006-01-12 | Effervescence granule of beautyberry and preparation method thereof |
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| Publication Number | Publication Date |
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| CN1840030A true CN1840030A (en) | 2006-10-04 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 200610020140 Pending CN1840030A (en) | 2006-01-12 | 2006-01-12 | Effervescence granule of beautyberry and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113663049A (en) * | 2021-09-22 | 2021-11-19 | 中国热带农业科学院热带作物品种资源研究所 | Li nationality medicine postpartum medicated bath effervescent granules and preparation method thereof |
-
2006
- 2006-01-12 CN CN 200610020140 patent/CN1840030A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113663049A (en) * | 2021-09-22 | 2021-11-19 | 中国热带农业科学院热带作物品种资源研究所 | Li nationality medicine postpartum medicated bath effervescent granules and preparation method thereof |
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Open date: 20061004 |