CN1833684A - Film cladded tablet for treating coronary heart disease - Google Patents
Film cladded tablet for treating coronary heart disease Download PDFInfo
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- CN1833684A CN1833684A CN 200610042191 CN200610042191A CN1833684A CN 1833684 A CN1833684 A CN 1833684A CN 200610042191 CN200610042191 CN 200610042191 CN 200610042191 A CN200610042191 A CN 200610042191A CN 1833684 A CN1833684 A CN 1833684A
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Abstract
A Chinese medicine in the form of coated tablets for treating coronary heart disease is prepared from 6 Chinese-medicinal materials including red sage root, Chuan-xiong rhizome, haw, astragalus root, etc. Its coating liquid is prepared from hydroxypropyl methylcellulose, polyethanediol, polyvitone, iron oxide red and purified water.
Description
1, technical field
The present invention relates to Chinese medicine preparation and preparation method thereof, specifically a kind of Chinese medicine thin membrane coated tablet for the treatment of coronary heart disease.
2, background technology
The deficiency that the coated tablet of prior art exists in actual applications is that sugar content height in (1) coating material has influenced taking of diabetics; (2) label medicine dissolution rate is slow, and the medicine produce effects is slow; (3) moisture absorption easily influences stability of drug and storage period; (4) coating color and luster instability, easily oxidized and influenced the character of medicine; (5) coating disperses all heterogeneities, and the opacity difference causes drug smell to distribute loss, has influenced the therapeutic effect of medicine.
3, summary of the invention
The Chinese medicine thin membrane coated tablet of treatment coronary heart disease of the present invention is summary and has overcome prior art existing deficiency, a kind of performance of further developing and the more excellent new product of effect in clinical and application on the basis of original coated tablet.The Chinese medicine preparation of treatment coronary heart disease of the present invention, be that Shandong Province's famous old docter of TCM's cycle Puritanism is awarded the theory relevant according to traditional Chinese medical science medical science QI and blood, full appreciation from coronary heart disease cause, pathogenesis, in conjunction with oneself clinical experience in more than 30 year, in line with conditioning human body, treating both the principal and secondary aspects of a disease, benefiting QI for activating blood circulation is main principle, the new medicine tablet product that prescription, and the production technology of employing modern Chinese medicine extractive technique and science is meticulously produced belongs to Chinese medicine three kind new medicines.
Its major advantage is:
1, Film coated tablets coating material adopt sugar-free formulation, removed the restriction of clinical practice, especially be subjected to vast diabetic coronary artery disease patient's favor.
2, the label of Film coated tablets adopts the extraction process of several different methods, and the active ingredient that has improved the label medicine has greatly improved the dissolution of medicine greatly in the process of clinical application, make the medicine produce effects faster.
3, owing to adopt the film-forming process of new film-coat, film-formation result is good, can effectively prevent the infiltration of moisture in the humid air, has increased stability of drug.
4, adopt new thin-film material prescription, strengthened the antioxidation discoloration, kept tablet appearance bright in luster, stablized the medicine character.
5, owing to the optimization of filmogen, filmogen is easy to atomizing, disperses homogeneous, and film forming is fast, hides, and can effectively cover the bad smell of Chinese medicine, is beneficial to and takes.
6, owing to label active ingredient height, the clothing layer is thin pliable and tough firmly smooth, and the great big minimizing of sheet is beneficial to transportation and storage more again.
4, embodiment
A kind of thin membrane coated tablet for the treatment of coronary heart disease of the present invention, wherein the weight portion of sheet core raw material consists of: Radix Puerariae 250-300 part; Radix Salviae Miltiorrhizae 250-300 part; Rhizoma Chuanxiong 30-50 part; Fructus Crataegi 250-300 part; Herba Visci 200-280 part; Radix Astragali 300-400 part;
The weight portion of coating solution raw material is formed: hydroxypropyl methylcellulose 3-8; Polyethylene Glycol 2-5 part; 30 POVIDONE K 30 BP/USP 30 3-5 parts; Iron oxide red color lake 0.3-2 part; Purified water 68-75 part;
Preparation process is as follows:
(1) take by weighing Radix Puerariae in proportion, be crushed to 150 orders, the concentration that adds 2 times of amounts is 85% ethanol, soaks 48 hours, filters, and filtering residue adds 85% soak with ethanol 24 hours of 2 times of amounts again, filter, and merging filtrate, concentrating under reduced pressure reclaims ethanol, and the collection concentrated solution is standby;
(2) take by weighing the Rhizoma Chuanxiong of Fructus Crataegi, Radix Salviae Miltiorrhizae and formula proportion 1/2 by formula proportion, the concentration that adds 2 times of amounts is 85% ethanol, soaks 48 hours, filter, filtering residue adds 85% soak with ethanol 24 hours of 2 times of amounts again, filters, merging filtrate, concentrating under reduced pressure reclaims ethanol, and it is standby to collect concentrated solution;
(3) take by weighing the Radix Astragali by formula proportion and Herba Visci is crushed to 200 orders, mix with the Rhizoma Chuanxiong of Fructus Crataegi, Radix Salviae Miltiorrhizae and formula proportion 1/2 after the alcohol extraction, the water logging that adds 2 times of amounts was steeped 24 hours, heated and boiled 30 minutes, the decocting that filtered while hot, filtering residue add 2 times of amounts again boiled 1 hour, filtered waste, merge filtrate twice, it is standby to be evaporated to pasty state;
(4) with remaining 1/2 Rhizoma Chuanxiong coarse crushing, through sterilization, drying, it is standby to be ground into 200 purpose fine powders;
(5) merge the extracting solution of (1), (2) and (3), stir, through conventional concentrating under reduced pressure, drying and pulverizing again with the fine powder mix homogeneously of Rhizoma Chuanxiong, it is standby to make label through the dry granulate tabletting of granulating again;
(6) preparation of coating solution: take by weighing hydroxypropyl methylcellulose by formula proportion; Polyethylene Glycol; 30 POVIDONE K 30 BP/USP 30 and iron oxide red color lake mix homogeneously; Earlier purified water is added in the agitator tank, allow agitator stretch into 2/3 place under the liquid level, start agitator, mixing speed is stirred the purified water in the container fully, liquid level just forms vortex and is advisable, coating powder at the uniform velocity is sprinkling upon on the vortex liquid level, being whipped into vortex rapidly with coating powder is advisable, along with the increase of solution viscosity, slowly improve mixing speed, to keep original vortex, whole whipping process should be finished in 2-5 minute, reinforced finishing reduces mixing speed to vortex and just disappears, continue to stir 45 minutes to coating materials molten fully loose standby;
(7) coating operation: label is inserted in the efficient film coating machine, open efficient film coating machine, regulating pot speed is 2-8 rev/min, and inlet temperature is 70-80 ℃, and intake is 2800-3000m
3/ h, control strip bed tempertaure are 35-45 ℃, and the adjusting atomizing pressure is 3.0-4.0kg/cm
2, opening peristaltic pump control spouting liquid is 140-240g/ minute, in the coating process, the sheet bed tempertaure maintains 35-45 ℃, when treating that the thin film clothing is wrapped on plain sheet surface fully, stop hydrojet, regulate fast 2-5 rev/min in pot, inlet temperature 60-70 ℃, intake 1500-2000m
3/ h until plain sheet dry tack free, reduces to room temperature, takes the dish out of the pot, test package is finished product.
Embodiment 1
Prescription:
By 1,000,000 calculating, the parts by weight of raw materials of label consists of: 260 kilograms of Radix Puerariaes; 270 kilograms of Radix Salviae Miltiorrhizaes; 45 kilograms of Rhizoma Chuanxiongs; 280 kilograms of Fructus Crataegis; 250 kilograms of Herba Viscis; 350 kilograms of the Radixs Astragali;
The weight portion of coating solution raw material is formed: hydroxypropyl methylcellulose 5; 3 kilograms of Polyethylene Glycol; 303 kilograms of 30 POVIDONE K 30 BP/USPs; 1 kilogram in iron oxide red color lake; 70 kilograms of purified water;
Preparation process is as follows:
(1) take by weighing Radix Puerariae in proportion, be crushed to 150 orders, the concentration that adds 2 times of amounts is 85% ethanol, soaks 48 hours, filters, and filtering residue adds 85% soak with ethanol 24 hours of 2 times of amounts again, filter, and merging filtrate, concentrating under reduced pressure reclaims ethanol, and the collection concentrated solution is standby;
(2) take by weighing the Rhizoma Chuanxiong of Fructus Crataegi, Radix Salviae Miltiorrhizae and formula proportion 1/2 by formula proportion, the concentration that adds 2 times of amounts is 85% ethanol, soaks 48 hours, filter, filtering residue adds 85% soak with ethanol 24 hours of 2 times of amounts again, filters, merging filtrate, concentrating under reduced pressure reclaims ethanol, and it is standby to collect concentrated solution;
(3) take by weighing the Radix Astragali by formula proportion and Herba Visci is crushed to 200 orders, mix with the Rhizoma Chuanxiong of Fructus Crataegi, Radix Salviae Miltiorrhizae and formula proportion 1/2 after the alcohol extraction, the water logging that adds 2 times of amounts was steeped 24 hours, heated and boiled 30 minutes, the decocting that filtered while hot, filtering residue add 2 times of amounts again boiled 1 hour, filtered waste, merge filtrate twice, it is standby to be evaporated to pasty state;
(4) with remaining 1/2 Rhizoma Chuanxiong coarse crushing, through sterilization, drying, it is standby to be ground into fine powder;
(5) merge the extracting solution of (1), (2) and (3), stir, through conventional concentrating under reduced pressure, drying and pulverizing again with the fine powder mix homogeneously of Rhizoma Chuanxiong, it is standby to make label through the dry granulate tabletting of granulating again;
(6) preparation of coating solution: take by weighing hydroxypropyl methylcellulose by formula proportion; Polyethylene Glycol; 30 POVIDONE K 30 BP/USP 30 and iron oxide red color lake mix homogeneously; Earlier purified water is added in the agitator tank, allow agitator stretch into 2/3 place under the liquid level, start agitator, mixing speed is stirred the purified water in the container fully, liquid level just forms vortex and is advisable, coating powder at the uniform velocity is sprinkling upon on the vortex liquid level, being whipped into vortex rapidly with coating powder is advisable, along with the increase of solution viscosity, slowly improve mixing speed, to keep original vortex, whole whipping process should be finished in 2-5 minute, reinforced finishing reduces mixing speed to vortex and just disappears, continue to stir 45 minutes to coating materials molten fully loose standby;
(7) coating operation: label is inserted in the efficient film coating machine, open efficient film coating machine, regulating pot speed is 8 rev/mins, and inlet temperature is 75 ℃, and intake is 2800-3000m
3/ h, control strip bed tempertaure are 42 ℃, and the adjusting atomizing pressure is 3.5kg/cm
2, opening peristaltic pump control spouting liquid is 220g/ minute, in the coating process, the sheet bed tempertaure maintains 42 ℃, when treating that the thin film clothing is wrapped on plain sheet surface fully, stops hydrojet, regulates 4 rev/mins of pot speed, 70 ℃ of inlet temperature, intake 2000m
3/ h until plain sheet dry tack free, reduces to room temperature, takes the dish out of the pot, test package is finished product.
Embodiment 2
Prescription:
The weight portion of sheet core raw material consists of: 300 kilograms of Radix Puerariaes; 260 kilograms of Radix Salviae Miltiorrhizaes; 45 kilograms of Rhizoma Chuanxiongs; 300 kilograms of Fructus Crataegis; 280 kilograms of Herba Viscis; 400 kilograms of the Radixs Astragali;
The weight portion of coating solution raw material is formed: hydroxypropyl methylcellulose 3-8; 5 kilograms of Polyethylene Glycol; 305 kilograms of 30 POVIDONE K 30 BP/USPs; 2 kilograms in iron oxide red color lake; 75 kilograms of purified water;
Preparation process is identical with embodiment 1.
Claims (3)
1, a kind of thin membrane coated tablet for the treatment of coronary heart disease is characterized in that the weight portion of sheet core raw material consists of:
Radix Puerariae 250-300 part; Radix Salviae Miltiorrhizae 250-300 part; Rhizoma Chuanxiong 30-50 part; Fructus Crataegi 250-300 part; Herba Visci 200-280 part; Radix Astragali 300-400 part;
The weight portion of coating solution raw material is formed: hydroxypropyl methylcellulose 3-8; Polyethylene Glycol 2-5 part; 30 POVIDONE K 30 BP/USP 303-5 part; Iron oxide red color lake 0.3-2 part; Purified water 68-75 part;
Preparation process is as follows:
(1) take by weighing Radix Puerariae in proportion, be crushed to 150 orders, the concentration that adds 2 times of amounts is 85% ethanol, soaks 48 hours, filters, and filtering residue adds 85% soak with ethanol 24 hours of 2 times of amounts again, filter, and merging filtrate, concentrating under reduced pressure reclaims ethanol, and the collection concentrated solution is standby;
(2) take by weighing the Rhizoma Chuanxiong of Fructus Crataegi, Radix Salviae Miltiorrhizae and formula proportion 1/2 by formula proportion, the concentration that adds 2 times of amounts is 85% ethanol, soaks 48 hours, filter, filtering residue adds 85% soak with ethanol 24 hours of 2 times of amounts again, filters, merging filtrate, concentrating under reduced pressure reclaims ethanol, and it is standby to collect concentrated solution;
(3) take by weighing the Radix Astragali by formula proportion and Herba Visci is crushed to 200 orders, mix with the Rhizoma Chuanxiong of Fructus Crataegi, Radix Salviae Miltiorrhizae and formula proportion 1/2 after the alcohol extraction, the water logging that adds 2 times of amounts was steeped 24 hours, heated and boiled 30 minutes, the decocting that filtered while hot, filtering residue add 2 times of amounts again boiled 1 hour, filtered waste, merge filtrate twice, it is standby to be evaporated to pasty state;
(4) with remaining 1/2 Rhizoma Chuanxiong coarse crushing, through sterilization, drying, it is standby to be ground into 200 purpose fine powders;
(5) merge the extracting solution of (1), (2) and (3), stir, through conventional concentrating under reduced pressure, drying and pulverizing again with the fine powder mix homogeneously of Rhizoma Chuanxiong, it is standby to make label through the dry granulate tabletting of granulating again;
(6) preparation of coating solution: take by weighing hydroxypropyl methylcellulose by formula proportion; Polyethylene Glycol; 30 POVIDONE K 30 BP/USP 30 and iron oxide red color lake mix homogeneously; Earlier purified water is added in the agitator tank, allow agitator stretch into 2/3 place under the liquid level, start agitator, mixing speed is stirred the purified water in the container fully, liquid level just forms vortex and is advisable, coating powder at the uniform velocity is sprinkling upon on the vortex liquid level, being whipped into vortex rapidly with coating powder is advisable, along with the increase of solution viscosity, slowly improve mixing speed, to keep original vortex, whole whipping process should be finished in 2-5 minute, reinforced finishing reduces mixing speed to vortex and just disappears, continue to stir 45 minutes to coating materials molten fully loose standby;
(7) coating operation: label is inserted in the efficient film coating machine, open efficient film coating machine, regulating pot speed is 2-8 rev/min, and inlet temperature is 70-80 ℃, and intake is 2800-3000m
3/ h, control strip bed tempertaure are 35-45 ℃, and the adjusting atomizing pressure is 3.0-4.0kg/cm
2, opening peristaltic pump control spouting liquid is 140-240g/ minute, in the coating process, the sheet bed tempertaure maintains 35-45 ℃, when treating that the thin film clothing is wrapped on plain sheet surface fully, stop hydrojet, regulate fast 2-5 rev/min in pot, inlet temperature 60-70 ℃, intake 1500-2000m
3/ h until plain sheet dry tack free, reduces to room temperature, takes the dish out of the pot, test package is finished product.
2, the thin membrane coated tablet of treatment coronary heart disease according to claim 1 is characterized in that the parts by weight of raw materials of label consists of: 260 parts of Radix Puerariaes; 270 parts of Radix Salviae Miltiorrhizaes; 45 parts of Rhizoma Chuanxiongs; 280 parts of Fructus Crataegis; 250 parts of Herba Viscis; 350 parts of the Radixs Astragali.
3, the thin membrane coated tablet of treatment coronary heart disease according to claim 1 is characterized in that the weight portion of coating solution raw material is formed: hydroxypropyl methylcellulose 5; 3 parts of Polyethylene Glycol; 30 3 parts of 30 POVIDONE K 30 BP/USPs; 1 part in iron oxide red color lake; 70 parts of purified water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610042191 CN1833684A (en) | 2006-01-09 | 2006-01-09 | Film cladded tablet for treating coronary heart disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610042191 CN1833684A (en) | 2006-01-09 | 2006-01-09 | Film cladded tablet for treating coronary heart disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1833684A true CN1833684A (en) | 2006-09-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610042191 Pending CN1833684A (en) | 2006-01-09 | 2006-01-09 | Film cladded tablet for treating coronary heart disease |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106075799A (en) * | 2016-07-08 | 2016-11-09 | 广西大学 | A kind of Chinese medicine composition of degrading polycyclic aromatic hydrocarbons |
| CN115252562A (en) * | 2022-08-17 | 2022-11-01 | 陕西方浩生物科技有限公司 | Preparation method of Zhengxintai granular traditional Chinese medicine composition |
| CN115282195A (en) * | 2022-08-17 | 2022-11-04 | 陕西方浩生物科技有限公司 | A Chinese medicinal composition for treating coronary heart disease and angina pectoris, and its preparation method |
-
2006
- 2006-01-09 CN CN 200610042191 patent/CN1833684A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106075799A (en) * | 2016-07-08 | 2016-11-09 | 广西大学 | A kind of Chinese medicine composition of degrading polycyclic aromatic hydrocarbons |
| CN106075799B (en) * | 2016-07-08 | 2019-08-30 | 广西大学 | A kind of Chinese medicine composition of degrading polycyclic aromatic hydrocarbons |
| CN115252562A (en) * | 2022-08-17 | 2022-11-01 | 陕西方浩生物科技有限公司 | Preparation method of Zhengxintai granular traditional Chinese medicine composition |
| CN115282195A (en) * | 2022-08-17 | 2022-11-04 | 陕西方浩生物科技有限公司 | A Chinese medicinal composition for treating coronary heart disease and angina pectoris, and its preparation method |
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Open date: 20060920 |