CN1709225A - Method for preparing health-care foods for auxiliary inhibiting tumour using polygonum cuspidatum extract - Google Patents
Method for preparing health-care foods for auxiliary inhibiting tumour using polygonum cuspidatum extract Download PDFInfo
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- CN1709225A CN1709225A CN 200510027574 CN200510027574A CN1709225A CN 1709225 A CN1709225 A CN 1709225A CN 200510027574 CN200510027574 CN 200510027574 CN 200510027574 A CN200510027574 A CN 200510027574A CN 1709225 A CN1709225 A CN 1709225A
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Abstract
The present invention relates to a method for preparing health-care food with auxiliary effect of inhibiting tumor by utilizing Chinese medicinal material bushy knotweed root extract. Said invention provides the concrete steps of said preparation method, and can ensure its resveratrol purity which must be above 17%, and can ensure that the resveratrol content in every capsule 300mg is not less than 34mg.
Description
Technical field
What the present invention relates to is a kind of preparation method of health product technology field, particularly a kind of auxiliary method that suppresses tumor health food of Rhizoma Polygoni Cuspidati extract preparation of utilizing.
Background technology
Tumor is a kind of common, multiple disease, and the people's life and health is caused serious threat, more and more comes into one's own in medical domain.The number that cancer is died from the whole world every year is more than 7,000,000, and now the cancer patient is about 3,700 ten thousand, annual neopathy 1,000,000 people of China, dead 800,000 people.Tumor is the complex disease of multimachine system, at present still with the treatment of comprehensive means such as early diagnosis, radiotherapy, chemotherapy.Antineoplastic biological medicament can sharply increase in 10 years from now on.Rhizoma Polygoni Cuspidati (polygonum cuspidatum sieb.et zucc.) is the Polygonaceae herbaceos perennial, is traditional Chinese herbal medicine of Pharmacopoeia of the People's Republic of China record.Its rhizome has effects such as promoting blood circulation to restore menstrual flow, inducing diuresis for treating stranguria syndrome and detoxifcation, cures mainly diseases such as rheumatism, bones and muscles pain and malignant boil tinea disease; Be used as resistance of hepatitis B and hemostasis among the people, respond well.Resveratrol is as a kind of polyphenols in the Rhizoma Polygoni Cuspidati, from U.S. scientist in 1997 at＜Science go up this material of report and have the prophylaxis of tumours effect since, receive the attention and the concern of the world of medicine always, and carried out a large amount of research.Studies show that up to now, resveratrol has effects such as antitumor, antioxidation, anti-cardiovascular disease, estrogen, antibacterium, antiinflammatory, anticoagulant and adjusting immunity, become the active skull cap components that scientists is paid much attention to, had very big medical value and market prospect.
Find through literature search prior art, the Chinese patent publication number is 1363355, " preparation method of hypolipemic giant knotweed rhizome tablet " by name, disclose in this patent Rhizoma Polygoni Cuspidati extract powder and two kinds of raw material mix homogeneously of Powdered lactose, and add an amount of carboxymethyl starch sodium and magnesium stearate mixing back film-making therein, obtain a kind of Rhizoma Polygoni Cuspidati tablet with hypolipemic function.Rhizoma Polygoni Cuspidati raw material gradation after will pulverizing in said extracted method or the technology decocts with water after-filtration, after the concentrating filter liquor, handle with 95% ethanol mix homogeneously sedimentation again, at last the stillness of night that obtains is carried out spray drying, cooperate other raw material to be developed into a kind of medicinal tablet simultaneously with hypolipemic function, but its functional component is indeterminate, and can not suppress tumor growth.
Summary of the invention
The present invention is directed to above-mentioned deficiency of the prior art, propose a kind of auxiliary method that suppresses tumor health food of Rhizoma Polygoni Cuspidati extract preparation of utilizing.Make it utilize resveratrol in the Rhizoma Polygoni Cuspidati extract, preparation has the efficiency health-care food that suppresses tumor growth.
The present invention is achieved by the following technical solutions, and step of the present invention is as follows:
(1) with Rhizoma Polygoni Cuspidati drying, pulverizing, use 50-95% edible ethanol heating and refluxing extraction 3 times, each consumption is respectively 5-20 times of Rhizoma Polygoni Cuspidati medical material weight, and extraction time is 0.5-5 hour, and merge extractive liquid, filters, and liquid film evaporation concentrates;
(2) be to carry out hig h-speed centrifugal spray drying under 80-120 ℃ with concentrated solution in temperature, obtaining yellow powder is Rhizoma Polygoni Cuspidati extract;
(3) with Rhizoma Polygoni Cuspidati extract dusty material, starch and maltose alcohol according to 10: 1: 0.5-20: 5: 2 ratio fully mixes, and obtains the auxiliary tumor health food that suppresses.
The auxiliary tumor health food that suppresses of the present invention can also be made capsule, and the content of resveratrol is more than 34mg in every capsules (300mg).
The present invention is raw material with the Rhizoma Polygoni Cuspidati, adopts the edible ethanol heating and refluxing extraction, and process is filtered, liquid film evaporation concentrates, hig h-speed centrifugal spray drying obtains yellow powder, is mixed and made into capsule with starch, maltose alcohol.The present invention utilizes effective extraction process, and the extract that contains the active component resveratrol of extraction is as base material, is equipped with lower calorific value sugar alcohol-maltose alcohol and the health food developed.Active component resveratrol wherein is proved to be, and it not only has prevention cardiovascular diseases effect and other medicine reasonable compatibility, and its active anticancer is 3 times of traditional anticarcinogen.By clinical observation, find that its anticancer total effective rate is 98.7% to 396 routine tumour patients.Resveratrol contains potent " preventing carcinoma new vessels somatomedin ", can suppress tumor neovasculature growth effectively, breaking off the supply of cancerous cell nutrition and the discharge of metabolism thing, thereby play direct control growth of tumor and transfer, is one of present most promising anticarcinogen.Maltose alcohol is a kind of lower calorific value sugar alcohol, so suitable equally diabetics of this product and obese patient crowd use.
The present invention carries out the high performance liquid chromatography quantitative analysis to Rhizoma Polygoni Cuspidati extract, and resveratrol purity is more than 17%, and good effect of the present invention: 1. Rhizoma Polygoni Cuspidati is the ancient Chinese crude drug plant of China, aboundresources; And this plant is successfully cultivated by China at present, so the raw material supply abundance; 2. preparation is simple, and production cost is low, environmentally safe: 3. determined that resveratrol is the functional component in the Rhizoma Polygoni Cuspidati extract: 4. the content of guaranteeing (300mg) resveratrol in every capsules is not less than 34mg.
The specific embodiment
Provide following examples in conjunction with content of the present invention:
Embodiment 1
With polygoni cuspidati,radix drying, pulverizing, with 50% edible ethanol heating and refluxing extraction, each consumption is 5 times of Rhizoma Polygoni Cuspidati medical material, and extraction time is 0.5h, and merge extractive liquid, filters, and liquid film evaporation concentrates.Concentrated solution is carried out hig h-speed centrifugal spray drying under 80 ℃, obtain yellow powder, itself and starch, maltose alcohol are made capsule with 10: 1: 0.5 mixed, the content of resveratrol is more than 34mg in every capsules.
Implementation result: with the mixture in the capsule mice that has transplanted tumor is fed, carried out the mice in vivo test one of every day, the result shows that its tumor suppression effect reaches 37.1%, has played the effect of auxiliary inhibition tumor growth.
Embodiment 2
With polygoni cuspidati,radix drying, pulverizing, with 70% edible ethanol heating and refluxing extraction, each consumption is 10 times of Rhizoma Polygoni Cuspidati medical material, and extraction time is 2h, and merge extractive liquid, filters, and liquid film evaporation concentrates.Concentrated solution is carried out hig h-speed centrifugal spray drying under 100 ℃, obtain yellow powder, itself and starch, maltose alcohol are made capsule with 15: 2: 1 mixed, the content of resveratrol is more than 34mg in every capsules.
Implementation result: with the mixture in the capsule mice that has transplanted tumor is fed, carried out the mice in vivo test one of every day, the result shows that its tumor suppression effect reaches 38.2%, has played the effect of auxiliary inhibition tumor growth.
Embodiment 3
With polygoni cuspidati,radix drying, pulverizing, with 95% edible ethanol heating and refluxing extraction, each consumption is 20 times of Rhizoma Polygoni Cuspidati medical material, and extraction time is 5h, and merge extractive liquid, filters, and liquid film evaporation concentrates.Concentrated solution is carried out hig h-speed centrifugal spray drying under 120 ℃, obtain yellow powder, itself and starch, maltose alcohol are made capsule with 20: 5: 2 mixed, the content of resveratrol is more than 17mg in every capsules.
Implementation result: with the mixture in the capsule mice that has transplanted tumor is fed, carried out the mice in vivo test one of every day, the result shows that its tumor suppression effect reaches 39.6%, has played the effect of auxiliary inhibition tumor growth.
Claims (6)
1, a kind of auxiliary method that suppresses tumor health food of Rhizoma Polygoni Cuspidati extract preparation of utilizing is characterized in that:
(1) with Rhizoma Polygoni Cuspidati drying, pulverizing, extract with alcohol heating reflux, merge extractive liquid, filters, and liquid film evaporation concentrates;
(2) concentrated solution is carried out hig h-speed centrifugal spray drying, obtaining yellow powder is Rhizoma Polygoni Cuspidati extract;
(3) Rhizoma Polygoni Cuspidati extract powder and starch, maltose alcohol are fully mixed, make health food.
2, the auxiliary method that suppresses tumor health food of Rhizoma Polygoni Cuspidati extract preparation of utilizing according to claim 1 is characterized in that in the step (1), described ethanol is the 50-95% edible ethanol.
3, according to claim 1 or the 2 described auxiliary methods that suppress tumor health food of Rhizoma Polygoni Cuspidati extract preparation of utilizing, it is characterized in that, in the step (1), extract 3 times with alcohol heating reflux, each consumption is respectively 5-20 times of Rhizoma Polygoni Cuspidati medical material weight, and extraction time is 0.5-5 hour.
4, the auxiliary method that suppresses tumor health food of Rhizoma Polygoni Cuspidati extract preparation of utilizing according to claim 1 is characterized in that, in the step (2), is to carry out hig h-speed centrifugal spray drying under 80-120 ℃ with concentrated solution in temperature.
5, the auxiliary method that suppresses tumor health food of Rhizoma Polygoni Cuspidati extract preparation of utilizing according to claim 1 is characterized in that in the step (3), Rhizoma Polygoni Cuspidati extract powder, starch and maltose alcohol blending ratio are 10: 1: 0.5-20: 5: 2.
6, according to claim 1 or the 5 described auxiliary methods that suppress tumor health food of Rhizoma Polygoni Cuspidati extract preparation of utilizing, it is characterized in that, Rhizoma Polygoni Cuspidati extract powder, starch and maltose alcohol are made capsule after mixing, and the content of resveratrol is more than 34mg among every capsules 300mg.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200510027574 CN1709225A (en) | 2005-07-07 | 2005-07-07 | Method for preparing health-care foods for auxiliary inhibiting tumour using polygonum cuspidatum extract |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101342130B (en) * | 2008-08-26 | 2010-06-02 | 上海相宜本草化妆品有限公司 | Preparation method for traditional Chinese medicine extract liquid with function of balancing and governing skin oil and fat, and products produced thereby |
| CN106727346A (en) * | 2016-12-08 | 2017-05-31 | 天津市益倍建生物技术有限公司 | A kind of resveratrol pellet preparation and preparation method thereof |
| CN107501431A (en) * | 2017-09-19 | 2017-12-22 | 李仲昆 | A kind of water-soluble giant knotweed polyoses extract and preparation method thereof and purposes |
-
2005
- 2005-07-07 CN CN 200510027574 patent/CN1709225A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101342130B (en) * | 2008-08-26 | 2010-06-02 | 上海相宜本草化妆品有限公司 | Preparation method for traditional Chinese medicine extract liquid with function of balancing and governing skin oil and fat, and products produced thereby |
| CN106727346A (en) * | 2016-12-08 | 2017-05-31 | 天津市益倍建生物技术有限公司 | A kind of resveratrol pellet preparation and preparation method thereof |
| CN107501431A (en) * | 2017-09-19 | 2017-12-22 | 李仲昆 | A kind of water-soluble giant knotweed polyoses extract and preparation method thereof and purposes |
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