CN1824023A - Medicine for treating gastropathy and gastrohelcosis and its preparation method - Google Patents
Medicine for treating gastropathy and gastrohelcosis and its preparation method Download PDFInfo
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- CN1824023A CN1824023A CNA2005100486932A CN200510048693A CN1824023A CN 1824023 A CN1824023 A CN 1824023A CN A2005100486932 A CNA2005100486932 A CN A2005100486932A CN 200510048693 A CN200510048693 A CN 200510048693A CN 1824023 A CN1824023 A CN 1824023A
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- powder
- seu herba
- rhizoma seu
- herba bergeniae
- endoconcha sepiae
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Abstract
A Chinese medicine in the form of powder for treating gastrosis and gastric ulcer, especially the cold accumulation type gastral cavity pain is proportionally prepared from the powder of Datura leaf, puple bergening herb powder and cuttlefish bone powder through mixing. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind ofly be used for the treatment of gastropathy and gastric ulcer and comprise treatment gastric abscess, acute or chronic gastritis, atrophic, superficial gastritis, gastric and duodenal ulcers, stomach spasm, medicine of gastropathy such as gastrorrhagia and preparation method thereof.
Background technology
The Chinese medicine and western medicine of existing treatment gastropathy is of a great variety, curative effect also varies with each individual, no matter be Western medicine or Chinese medicine, after taking, the patients with gastric disease that has to tell on, and the patients with gastric disease that has is difficult to tell on after taking, and it is very little perhaps to tell on, and many medicines are bigger in the produced simultaneously side effect of treatment gastropathy, take back regular meeting and follow symptoms such as some vomitings, tired, acid regurgitation, diarrhoea, anorexia, cause many patients with gastric disease to be reluctant to take or to be reluctant and take for a long time; For some cold-condensing type gastric abscess patients, take existing conventional stomach medicine after stomach can feel very uncomfortable.
Summary of the invention
Purpose of the present invention disclose vary with each individual on a kind of curative effect in confused situation apparent just in order to overcome the weak point that above-mentioned existing stomach medicine exists, drug side effect is little especially especially significantly is used for the treatment of medicine of gastropathy and gastric ulcer and preparation method thereof to cold-condensing type gastric abscess effect.
The objective of the invention is to realize by following technical solution.
Pharmaceutical formulation of the present invention: Folium daturae powder, Rhizoma Seu Herba Bergeniae powder and Endoconcha Sepiae powder three herbal medicine powder are mixed (by weight percentage) by following prescription: Folium daturae powder 20～80%, Rhizoma Seu Herba Bergeniae powder 19～79%, the prescription total amount of Endoconcha Sepiae powder 1～8%, three herbal medicine powder adds up to 100%.
The present invention also provides a kind of medicine powder, preparation method thereof that mixes according to above-mentioned three herbal medicine prescriptions.
1, Folium daturae powder preparation technique: Folium daturae is chosen clean, avoid washing, steam, with after water is heated to boiling in the steamed tool, in the steaming lattice of steamed tool, put into Folium daturae more earlier, add a cover the back and keep steaming water in 70～100 ℃ of scopes, to continue heating 20～40 minutes, after emitting steam to the steamed tool top cover, taking-up Folium daturae to be cooled slightly, 40～60 ℃ of oven dry, fine ground powder is crossed 80～200 mesh sieves with Folium daturae.
2, Rhizoma Seu Herba Bergeniae powder and Endoconcha Sepiae powder preparation technique: Rhizoma Seu Herba Bergeniae is chosen only, be cut into the segment of 1～2 centimeter length; Endoconcha Sepiae is worn into 50～70 orders, press Rhizoma Seu Herba Bergeniae: the weight proportion relation of Endoconcha Sepiae powder=1: 0.1～0.8, earlier Rhizoma Seu Herba Bergeniae is dropped into the heating that stir-fries in the pot of slow fire, the Endoconcha Sepiae powder being put into pot mixes with the Rhizoma Seu Herba Bergeniae that heats again, fry to the Rhizoma Seu Herba Bergeniae yellow skin and play pot when not burnt, cool, it is standby to cross 80～200 sieve Endoconcha Sepiae powder, and the Rhizoma Seu Herba Bergeniae of parch is ground into fine powder, and to cross 80～200 mesh sieves standby.
Medicine powder process mixture by above-mentioned three flavor prescription preparations is prepared into oral solid formulation by the pharmaceutics conventional method, as powder, granule, capsule, plain sheet and coated tablet, dispersible tablet, buccal tablet.
Because Folium daturae has removed oxious component in steaming process, kept active ingredient, and the fine sanguimotor drug action of its analgesia, antiinflammatory, sterilization, promotion after powder process is enhanced; Rhizoma Seu Herba Bergeniae with the parch process of Endoconcha Sepiae in, the Endoconcha Sepiae powder has fully dissolved in into the Rhizoma Seu Herba Bergeniae section when heating, the antiinflammatory of Rhizoma Seu Herba Bergeniae section, the drug effect of astriction are strengthened greatly, in preparation, add the Endoconcha Sepiae powder of some parches again, increase the effect of hemostasis, convergence and healing wound surface, guaranteed the integrity of the present invention's prescription.
Quote experimental data below the present invention and embodiment further specifies, but institute's experimental data of quoting and embodiment do not form restriction to covering scope of the present invention.
(1) experimental data
1, to the protective effect of gastric mucosa
Get body weight 150～180g SD rat, water is can't help in fasting, is divided into 3 groups behind the 24h at random, and 10 every group, the peaceful 0.05g/kg of cloud stomach (low dose group), 0.2g/kg (high dose group) and matched group thunder Buddhist nun fourth 0.05g/kg group.Each treated animal is all irritated stomach with the 1ml/100g body weight, 1 time/d, is total to 7d.Behind the slight anesthetized rat of ether, its clinostatism is fixed on the rat fixation steel plate, and the animal that will fix is with soft metal net appropriateness one week of parcel.After last is irritated stomach 30min with fixed rat uprightly be dipped in 23 ℃ thermostatic water bath not, the water surface is advisable with neat xiphoid-process.Take off neck continuously behind the 24h and put to death, open the abdominal cavity, get stomach behind ligation pylorus and the cardia.Inject the 6ml normal saline by gastric gland portion, put it in 1% formalin fixedly 10min, cut off along greater gastric curvature again, observe gastric mucosa.As seen the gastric mucosa of experimental group rat is level and smooth, high dose group especially, and experimental group obviously is better than matched group (ranitidine group).
(2) embodiment:
Embodiment 1 gets Folium daturae 1.3kg, choose clean, avoid washing, steam, earlier with after water is heated to boiling in the steamed tool, in the steaming lattice of steamed tool, put into Folium daturae again, add a cover continue to be heated to top cover and emit steam after, fall in the steamed tool water temperature to 90 and ℃ steamed 30 minutes, taking-up Folium daturae to be cooled slightly, the Folium daturae that steams is dried in 50 ℃ of dehydrators, and fine ground powder is crossed 100 mesh sieves, and is standby.
Other gets Rhizoma Seu Herba Bergeniae 1kg, choose clean, be cut into the segment of 1 centimeter length, get Endoconcha Sepiae powder 0.3kg, earlier Rhizoma Seu Herba Bergeniae is dropped in the medicine roasting machine slow fire heating that stir-fries, again the Endoconcha Sepiae powder is put into pot and mixed with the Rhizoma Seu Herba Bergeniae that heats, fry to the Rhizoma Seu Herba Bergeniae yellow skin and play pot when not burnt, cool, the Endoconcha Sepiae powder that sieves is standby, and the Rhizoma Seu Herba Bergeniae of parch is ground into fine powder, and to cross 100 mesh sieves standby.
Get and standby steam Folium daturae powder process and Rhizoma Seu Herba Bergeniae powder process and Endoconcha Sepiae powder process respectively by Folium daturae powder process 50 grams, Rhizoma Seu Herba Bergeniae powder process 48 grams, three kinds of powder process mix homogeneously of Endoconcha Sepiae powder process 2 grams, cross 100 mesh sieves, capsule is made in filling, every medicine weighs 0.2 gram, oral, 3 times on the one, one time 1～2.
Embodiment 2 gets Folium daturae 1.3kg, choose clean, avoid washing, steam, earlier with after water is heated to boiling in the steamed tool, in the steaming lattice of steamed tool, put into Folium daturae again, add a cover continue to be heated to top cover and emit steam after, fall in the steamed tool water temperature to 70 and ℃ steamed 40 minutes, taking-up Folium daturae to be cooled slightly, 40 ℃ of oven dry, fine ground powder is crossed 150 mesh sieves, and is standby with the Folium daturae that steams.
Other gets Rhizoma Seu Herba Bergeniae 1kg, choose clean, be cut into the segment of 2 centimeter length, get Endoconcha Sepiae powder 0.3kg, earlier Rhizoma Seu Herba Bergeniae is dropped in the medicine roasting machine slow fire heating that stir-fries, again the Endoconcha Sepiae powder is put into pot and mixed with the Rhizoma Seu Herba Bergeniae that heats, fry to the Rhizoma Seu Herba Bergeniae yellow skin and play pot when not burnt, cool, the Endoconcha Sepiae powder that sieves is standby, and the Rhizoma Seu Herba Bergeniae of parch is ground into fine powder, and to cross 150 mesh sieves standby.
Get and standby steam Folium daturae powder process and Rhizoma Seu Herba Bergeniae powder process and Endoconcha Sepiae powder process respectively by Folium daturae powder process 20 grams, Rhizoma Seu Herba Bergeniae powder process 79 grams, three kinds of powder process mix homogeneously of Endoconcha Sepiae powder process 1 gram, cross 150 mesh sieves, capsule is made in filling, every medicine weighs 0.2 gram, oral, 3 times on the one, one time 1～2.
Embodiment 3 gets Folium daturae 1.3kg, choose clean, avoid washing, steam, earlier with after water is heated to boiling in the steamed tool, in the steaming lattice of steamed tool, put into Folium daturae again, add a cover continue to be heated to top cover and emit steam after, fall in the steamed tool water temperature to 80 and ℃ steamed 20 minutes, taking-up Folium daturae to be cooled slightly, 50 ℃ of oven dry, fine ground powder is crossed 80 mesh sieves, and is standby with the Folium daturae that steams.
Other gets Rhizoma Seu Herba Bergeniae 1kg, choose clean, be cut into the segment of 2 centimeter length, get Endoconcha Sepiae powder 0.3kg, earlier Rhizoma Seu Herba Bergeniae is dropped in the medicine roasting machine slow fire heating that stir-fries, again the Endoconcha Sepiae powder is put into pot and mixed with the Rhizoma Seu Herba Bergeniae that heats, fry to the Rhizoma Seu Herba Bergeniae yellow skin and play pot when not burnt, cool, the Endoconcha Sepiae powder that sieves is standby, and the Rhizoma Seu Herba Bergeniae of parch is ground into fine powder, and to cross 80 mesh sieves standby.
Get and standby steam Folium daturae powder process and Rhizoma Seu Herba Bergeniae powder process and Endoconcha Sepiae powder process respectively by Folium daturae powder process 80 grams, Rhizoma Seu Herba Bergeniae powder process 19 grams, three kinds of powder process mix homogeneously of Endoconcha Sepiae powder process 1 gram, cross 80 mesh sieves, capsule is made in filling, every medicine weighs 0.2 gram, oral, 3 times on the one, one time 1～2.
Embodiment 4 gets Folium daturae 2kg, choose clean, avoid washing, steam, earlier with after water is heated to boiling in the steamed tool, in the steaming lattice of steamed tool, put into Folium daturae again, add a cover continue to be heated to top cover and emit steam after, fall in the steamed tool water temperature to 90 and ℃ steamed 30 minutes, taking-up Folium daturae to be cooled slightly, the Folium daturae that steams is dried in 50 ℃ of dehydrators, and fine ground powder is crossed 100 mesh sieves, and is standby.
Other gets Rhizoma Seu Herba Bergeniae 1.5kg, choose clean, be cut into the segment of 1 centimeter length, get Endoconcha Sepiae powder 0.5kg, earlier Rhizoma Seu Herba Bergeniae is dropped in the medicine roasting machine slow fire heating that stir-fries, again the Endoconcha Sepiae powder is put into pot and mixed with the Rhizoma Seu Herba Bergeniae that heats, fry to the Rhizoma Seu Herba Bergeniae yellow skin and play pot when not burnt, cool, the Endoconcha Sepiae powder that sieves is standby, and the Rhizoma Seu Herba Bergeniae of parch is ground into fine powder, and to cross 100 mesh sieves standby.
Get and standby steam Folium daturae powder process and Rhizoma Seu Herba Bergeniae powder process and Endoconcha Sepiae powder process respectively by Folium daturae powder process 60 grams, Rhizoma Seu Herba Bergeniae powder process 32 grams, three kinds of powder process mix homogeneously of Endoconcha Sepiae powder process 8 grams, cross 100 mesh sieves, capsule is made in filling, every medicine weighs 0.2 gram, oral, 3 times on the one, one time 1～2.
Claims (2)
1, a kind of medicine that is used for the treatment of gastropathy and gastric ulcer, it is characterized in that, it mixes (by weight percentage) by Folium daturae powder, Rhizoma Seu Herba Bergeniae powder and Endoconcha Sepiae powder three herbal medicine powder by following prescription: Folium daturae powder 20～80%, Rhizoma Seu Herba Bergeniae powder process 19～79%, the prescription total amount of Endoconcha Sepiae powder 1～8%, three herbal medicine powder is 100%.
2, a kind of medicine powder, preparation method thereof according to claim 1 prescription, the Folium daturae powder preparation technique is: Folium daturae is chosen clean, avoid washing, steam, earlier with after water is heated to boiling in the steamed tool, in the steaming lattice of steamed tool, put into Folium daturae again, add a cover the back and keep to steam water and in 70～100 ℃ of scopes, continues to heat 20～40 minutes, emit steam to the steamed tool top cover after, taking-up Folium daturae to be cooled slightly, 40～60 ℃ of oven dry, fine ground powder is crossed 80～200 mesh sieves with Folium daturae;
Rhizoma Seu Herba Bergeniae powder and Endoconcha Sepiae powder preparation technique are: Rhizoma Seu Herba Bergeniae is chosen only, be cut into the segment of 1～2 centimeter length; Endoconcha Sepiae is worn into 50～70 orders, press Rhizoma Seu Herba Bergeniae: the weight proportion relation of Endoconcha Sepiae powder=1: 0.1～0.8, earlier Rhizoma Seu Herba Bergeniae is dropped into the heating that stir-fries in the pot of slow fire, the Endoconcha Sepiae powder being put into pot mixes with the Rhizoma Seu Herba Bergeniae that heats again, fry to the Rhizoma Seu Herba Bergeniae yellow skin and play pot when not burnt, cool, the Endoconcha Sepiae powder that sieves is standby, the Rhizoma Seu Herba Bergeniae of parch is ground into fine powder cross 80～200 mesh sieves.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2005100486932A CN100482255C (en) | 2005-12-15 | 2005-12-15 | Medicine for treating gastropathy and gastrohelcosis and its preparation method |
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| CNB2005100486932A CN100482255C (en) | 2005-12-15 | 2005-12-15 | Medicine for treating gastropathy and gastrohelcosis and its preparation method |
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| CN1824023A true CN1824023A (en) | 2006-08-30 |
| CN100482255C CN100482255C (en) | 2009-04-29 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103610962A (en) * | 2013-10-29 | 2014-03-05 | 于巧媛 | Traditional Chinese medicinal composition for treating singultus |
| CN111789902A (en) * | 2020-09-02 | 2020-10-20 | 朱明浩 | Application of content in Yunweining capsule in preparing anti-helicobacter pylori medicine |
-
2005
- 2005-12-15 CN CNB2005100486932A patent/CN100482255C/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103610962A (en) * | 2013-10-29 | 2014-03-05 | 于巧媛 | Traditional Chinese medicinal composition for treating singultus |
| CN103610962B (en) * | 2013-10-29 | 2016-04-06 | 于巧媛 | A kind of Chinese medicine composition of cure hiccup |
| CN111789902A (en) * | 2020-09-02 | 2020-10-20 | 朱明浩 | Application of content in Yunweining capsule in preparing anti-helicobacter pylori medicine |
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| Publication number | Publication date |
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| CN100482255C (en) | 2009-04-29 |
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Effective date of registration: 20160329 Address after: 650106 No. 176, medical Road, hi tech Industrial Development Zone, Yunnan, Kunming Patentee after: Kunming herb Pharmaceutical Co Ltd Address before: 650031 Kunming Teachers College, Kunming Road, Kunming City, Yunnan Province Patentee before: Wang Tong |
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Address after: 650106 No. 176, medical Road, hi tech Industrial Development Zone, Yunnan, Kunming Patentee after: Yunnan lanlokan Pharmaceutical Co., Ltd. Address before: 650106 No. 176, medical Road, hi tech Industrial Development Zone, Yunnan, Kunming Patentee before: Kunming herb Pharmaceutical Co Ltd |