CN102935171B - Aerosol for treating recurrent oral ulceration and preparation process of aerosol - Google Patents

Abstract

The invention discloses an aerosol for treating recurrent oral ulceration and a preparation process of the aerosol and belongs to the field of Chinese medicine preparations. The aerosol comprises, by weight, 50-70 parts of dried radix rehmanniae, 50-70 parts of radix rehmanniae preparata, 50-65 parts of radix paeoniae alba, 50-65 parts of bighead atractylodes rhizome, 45-60 parts of radix scutellariae, 45-60 parts of rheum officinale, 40-55 parts of asparagus cochinchinensis, 40-55 parts of radix ophiopogonis, 35-50 parts of liquorice, 35-50 parts of platycodon grandiflorum, 35-50 parts of root barks of peony trees, 35-50 parts of poria cocos, 30-40 parts of radix scrophulariae, 20-30 parts of rhizoma cyperi, 10-20 parts of cortex magnoliae officinalis and 6-15 parts of immature bitter oranges. According to the aerosol and the preparation process, selected medicinal materials are good in compatibility, drug properties are synergetic with one another, the vitality can be nourished, the spleen and the stomach can be invigorated, the flow of vital energy can be regulated, melancholy can be dispelled, bodily functions can be regulated and the pain can be relieved for the mechanism of the oral ulceration, and the aerosol and the preparation process have the advantages of being capable of treating symptoms, curing permanently and searching for the primary cause of the disease in treatment; and the aerosol and the preparation process are proven by clinical examination to be good in absorbing effect, effective in treatment, safe, reliable, free from toxic and side effects and clinical adverse effects and effective in treatment of the recurrent oral ulceration.

Description

A kind of aerosol and preparation method for the treatment of recurrent oral ulceration

Affiliated technical field

The present invention relates to field of traditional Chinese, relate in particular to a kind of aerosol and preparation method for the treatment of recurrent oral ulceration.

Background technology

Oral ulcer, is called again " aphtha ", is the superficial ulcer occurring on oral mucosa, and large I is size from the grain of rice to Semen Glycines, circular or oval, and ulcer surface is pit, congested around.Oral ulcer has the features such as periodicity, recurrent and self limiting, is apt to occur in lip, cheek and lingual margin position.Modern medicine study discovery, the cause of disease of oral ulcer and mechanism of causing a disease are still indefinite, and inducement may be local wound, psychentonia, hormonal readiness change and vitamin or trace element deficiency.During oral ulcer outbreak, patient part tingles unbearably, and diet all can be affected, and severe patient even be can't take care of oneself.

Because the pathogenesis of oral ulcer is still clear at present, lack and can be used as the lab index of making a definite diagnosis foundation, clinical diagnosis can only be based on medical history and clinicing aspect judgement.Most of doctors think, oral ulcer may with digestive system disease and dysfunction, hormonal change, Nervous and Mental Factors, inherited genetic factors, and microelement zinc, ferrum, folic acid, vitamin B12 deficiency cause, simultaneously laboratory research also shows, the antibacterials such as Streptococcus sanguis and helicobacter pylori and oral ulcer also have certain dependency.On clinical treating, generally adopt medicine rinsing the mouth or the external applications such as furan woods liquid, borate, a shellfish liquid, sodium bicarbonate, hydrogen peroxide, in order to diminishing inflammation, reducing swelling and alleviating pain, promote ulcer healing.This method is mainly to kill local antibacterial by antibiotic, healing of canker sores fundamentally, and the immune system of human body self is still depended in its recovery from illness.

According to the theoretical system of the traditional Chinese medical science, the cause of disease one of oral ulcer is diseases caused by exogenous pathogenic factor six climate exopathogens, dryness-fire two heresies, impairment of body fluid liquid; The 2nd, eating and drinking without temperance, consumes cloudy Tianjin of sad lung kidney; The 3rd, emotional stress, excessive thinking, strongly fragrant and fire-transformation, the smoked dispute of burning of getting angry; The 4th, plain body is cloudy to be lost, deficiency-fire produced in the interior, the dispute of burning; The 5th, overstrain internal injury, damage of spleen-QI, water wet and do not transport; The 6th, congenital natural endowment is not enough, deficiency of spleen-YANG and kidneyYANG, yin-cold excess, blood stasis due to accumulation of cold.Mostly existing oral ulcer Chinese medicinal formulae, be to treat based on blood stasis dispelling evil removing, the outer puzzled thinking of expeling, do not consider the impact of Nervous and Mental Factors, especially lacks compatibility not smooth for digestive system, excessive thirst.

Summary of the invention

The invention provides a kind of aerosol and preparation method for the treatment of recurrent oral ulceration, for the cause of disease of recurrent oral ulceration, the reasonably combined medium-height grass property of medicine, reaches warming middle-JIAO QI invigorating, arranges the object of strongly fragrant removing toxic substances, and recurrent oral ulceration is had to good curative effect.

For achieving the above object, technical scheme of the present invention is implemented as follows:

Treat an aerosol for recurrent oral ulceration, raw material composition and the parts by weight of making described aerosol effective ingredient are:

50～65 parts of 50～65 parts of Rhizoma Atractylodis Macrocephalaes of 50～70 portions of Radix Paeoniae Albas of 50～70 parts of Radix Rehmanniaes Preparata of the Radix Rehmanniae

40～55 parts of 45～60 parts of Radix Asparagis of 45～60 parts of Radix Et Rhizoma Rhei of Radix Scutellariae 40～55 parts of Radix Ophiopogonis

35～50 parts, 35～50 parts of Poria of 35～50 parts of Cortex Moutans of 35～50 parts of Radix Platycodoniss of Radix Glycyrrhizae

6～15 parts of 10～20 parts of Fructus Aurantii Immaturuss of 20～30 parts of Cortex Magnoliae Officinalis of 30～40 portions of Rhizoma Cyperis of Radix Scrophulariae

Raw material composition and the parts by weight of making described aerosol effective ingredient are:

52～60 parts of 52～60 parts of Rhizoma Atractylodis Macrocephalaes of 55～65 portions of Radix Paeoniae Albas of 55～65 parts of Radix Rehmanniaes Preparata of the Radix Rehmanniae

45～50 parts of 50～55 parts of Radix Asparagis of 50～55 parts of Radix Et Rhizoma Rhei of Radix Scutellariae 45～50 parts of Radix Ophiopogonis

40～45 parts, 40～45 parts of Poria of 40～45 parts of Cortex Moutans of 40～45 parts of Radix Platycodoniss of Radix Glycyrrhizae

8～12 parts of 13～18 parts of Fructus Aurantii Immaturuss of 23～27 parts of Cortex Magnoliae Officinalis of 32～36 portions of Rhizoma Cyperis of Radix Scrophulariae

Raw material composition and the parts by weight of making described aerosol effective ingredient are:

55 parts of 55 parts of Rhizoma Atractylodis Macrocephalaes of 60 portions of Radix Paeoniae Albas of 60 parts of Radix Rehmanniaes Preparata of the Radix Rehmanniae

47 parts of 53 parts of Radix Asparagis of 52 parts of Radix Et Rhizoma Rhei of Radix Scutellariae 48 parts of Radix Ophiopogonis

42 parts, 43 parts of Poria of 43 parts of Cortex Moutans of 41 parts of Radix Platycodoniss of Radix Glycyrrhizae

9 parts of 15 parts of Fructus Aurantii Immaturuss of 24 parts of Cortex Magnoliae Officinalis of 33 portions of Rhizoma Cyperis of Radix Scrophulariae

Treat a preparation method for the aerosol of recurrent oral ulceration, comprise following processing step:

(1) Rhizoma Cyperi, Fructus Aurantii Immaturus are stirred to micro-coke yellow that is with wheat bran, in the ratio of 10:10:1, get respectively Rhizoma Cyperi, Fructus Aurantii Immaturus, wheat bran, grind as smalls, cross 120 order fine powders, standby.

(2) Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Poria, Radix Scrophulariae are put into container, add the Ji Me Lao Jiu of triplication, hot digestion 2～3 hours, gets liquid; In remaining medicinal residues, add the Ji Me Lao Jiu of one times of amount, hot digestion 1～2 hour, gets liquid again; The liquid that boils that merges twice gained, the thick paste of simmer down to relative density 1.2～1.25 under 70 ℃ of temperature controls.

(3) Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Asparagi, Radix Ophiopogonis, Radix Glycyrrhizae, Radix Platycodonis, Cortex Moutan, Cortex Magnoliae Officinalis are put into container, add the water of four times of amounts, soak after 4～6 hours, get liquid; In remaining medicinal residues, add again the water of doubling dose, soak after 2～3 hours, get liquid; The medicinal liquid that merges twice gained, the thick paste of simmer down to relative density 1.15～1.20 under 60 ℃ of temperature controls.

(4) by after the thick paste mixing and stirring of the fine powder of step (1) gained and step (2), step (3) gained, be lyophilized into rapidly after powder, be prepared as aerosol.

The property of medicine of the present invention's Chinese medicine used is as follows:

The Radix Rehmanniae: sweet in the mouth; Bitter; Cold nature.GUIXIN; Liver; Kidney channel.Nourishing YIN and clearing away heat; Removing heat from blood is enriched blood.Cure mainly calentura excessive thirst; Interior-heat is quenched one's thirst; Hectic fever due to YIN-deficiency consumptive fever; Epidemic febrile disease is sent out speckle; Haematemesis due to heat in blood; Blood deficiency and yellow complexion; Dizzy cardiopalmus.< < Japan hanako materia medica > > carries: " control palpitation with fear labor bad, cardiopulmonary damage, spit blood, and epistaxis, married woman's metrorrhagia bruise, helps muscles and bones." modern medicine study confirms, the Radix Rehmanniae is effective immunostimulant, comprise the beneficial multiclass aminoacid of human body, multiclass saccharide, and have heart tonifying, diuresis, blood pressure lowering, blood sugar lowering, protect the liver, the pharmacological action such as antibacterial, hemocytes increasing.

Radix Rehmanniae Preparata: sweet in the mouth; Warm in nature; Return liver; Kidney channel.Enrich blood moist; Benefit essence is filled out marrow.Cure mainly blood tiger sallow; Dizzy cardiopalmus; Hepatic and renal YIN deficiency; Soreness of the waist and knees; The dyspnea with rapid and short breath of suffering from a deficiency of the kidney.< < book on Chinese herbal medicine converges says that > > carries: " the cloudy wound of prolonged illness, newly produces blood and lose, the essential person of institute also." modern medicine study confirmation, Radix Rehmanniae Preparata can strengthen the active content with reducing LPO in serum of GSH-Px, improves plasma A D concentration, also has closely-related effect with medulla hematopoietic system.

The Radix Paeoniae Alba: bitter in the mouth; Property is put down.Enter liver; Spleen channel.Nourishing blood to suppress the hyperactive liver, slow middle pain relieving; Yin fluid astringing is received antiperspirant.Cure mainly dysentery stomachache, spontaneous sweating, fever due to yin deficiency.< < does not record > > and carries: " clear and coherent blood vessels, in delaying, dispelling malignant blood, expelling extravasated blood, the gas that anhydrates, sharp bladder, intestine and small intestine, subduing inflammation, row cold and heat while controlling, attacked by pestiferous factors stomachache." modern medicine study confirms; the Radix Paeoniae Alba can regulate immunity, strengthens macrophage and leukocytic phagocytic function, the immunologic function of adjusting T lymphocyte and body fluid; protect the liver, spasmolytic, analgesia, calmness, resist cool, cooling effect, strengthen in addition the effect of anoxia enduring, antioxidation and resisting fatigue.

The Rhizoma Atractylodis Macrocephalae: bitter in the mouth; Sweet; Warm in nature.Return spleen; Stomach warp.Invigorating the spleen and benefiting QI; Dampness diuretic.Cure mainly deficiency-weakness of spleen-QI; Spiritlessness and weakness; Lack of appetite abdominal distention; Large loose stool is thin; Fluid-retention stagnating in the interior; Dysuria; Edema; Dizziness due to fluid-retention; Arthralgia chiefly caused by damp pathogen is ached; Spontaneous sweating due to deficiency of QI.< < herbal classic meets former > > to carry: " dehumidifying benefit is dry, and expectorant diuretic, and middle QI invigorating, slake thirst and help produce saliva, and enters diet." modern medicine study confirmation; the Rhizoma Atractylodis Macrocephalae can strengthen the phagocytic function of reticuloendothelial system and the ability of leukocytes phagocytic staphylococcus aureus; improve lymhocyte transformation rate; promote cellular immune function, Hemolytic streptococcus, viridans streptococci, diphtheria corynebacterium, bacillus subtilis are had to inhibitory action in various degree.

Radix Scutellariae: acrid in the mouth; Bitter; Cold in nature.Return lung; Liver; Kidney channel.Heat-clearing and toxic substances removing; Dissipating blood stasis hemostasis; Inducing diuresis to remove edema.Cure mainly pyretic toxicity carbuncle; Have sore throat; Lung abscess; Intestinal carbuncle; Scrofula; Spit blood; Epistaxis; Stranguria with blood; Edema; Ascites and cancer.< < Quanzhou book on Chinese herbal medicine > > carries: " heat clearing away, removing toxic substances, method wind, loose blood, circulation of qi promoting, diuretic, dredging collateral, removing blood stasis with potent drugs, pain relieving.Main stranguria with blood for oral administration, spits blood, epistaxis." modern medicine study confirmation, Radix Scutellariae has broad-spectrum antibacterial action, also has in addition the effect of antiplatelet aggregation, anticoagulant and blood fat reducing.

Radix Et Rhizoma Rhei: bitter in the mouth; Cold in nature.Enter stomach; Large intestine; Liver; Spleen channel.Attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Removing toxic substances.Cure mainly excess-heat constipation; The accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery; Gonorrhea; Edema abdominal distention; Dysuria; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Gastropyretic vomiting; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Hematuria; Blood-retention; WEIJIA is gathered; Pyretic toxicity carbuncle and ulcer.< < Japan hanako materia medica > > carries: " sharp joint, rushes down and stop up stagnant, aqueous vapor for logical all gas of a surname, blood circulation regulating, and applies all furuncle carbuncle poison." modern medicine study confirmation, Radix Et Rhizoma Rhei has broad-spectrum antiviral, antibacterial and antimycotic effect, can be used for the control of various inflammation, regulates in addition in addition immunologic function, and diseases of urinary system is had to prevention and therapeutical effect clearly.

radix Asparagi: sweet in the mouth; Bitter; Cold in nature; Enter lung; Kidney channel.Nourshing Yin and drynsessmoistening prescription; Lung heat clearing pathogenic fire reducing.Cough caused by dryness-heat; Deficiency of YIN chronic cough; Consumption of YIN caused by febrile disease; Interior-heat is quenched one's thirst; Dryness of the intestine constipation; Laryngopharynx swelling and pain.< < book on Chinese herbal medicine converges says that > > carries: " except inclined to one side numbness, bone strengthening marrow, control lung-heat and become flaccidity, kidney-heat marrow is withered, and the inclined to one side numbness person of the withered not Rong Ercheng of muscle also." modern medicine study confirmation; Radix Asparagi all has bacteriostasis in various degree to anthrax bacillus, A type and beta hemolytic streptococcus, diphtheria corynebacterium, diphtheroid, bacillus subtilis; leukocytic dehydrogenase is had to certain inhibitory action, and can suppress the leukocytic breathing of acute lymphoblastic type leukaemic.

radix Ophiopogonis: sweet in the mouth; Micro-hardship; Cold nature.GUIXIN; Lung; Stomach warp.YIN nourishing and the production of body fluid promoting; Lung moistening clears away heart-fire.Cure mainly dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.< < Mingyi Bielu > > carries: " treat heavy sensation of the body icteric sclera, rami cardiaci inferiores is full, asthenia exopathogenic heat, xerostomia excessive thirst; more flaccidity falls, and reinforcing YIN-essence benefit essence, during rapid digestion of food is adjusted; protect god, determine lung qi, settling five organs." modern medicine study confirmation, contain the effect of leukocyte increasing, prolongation antibody life period Radix Ophiopogonis, improve immunologic function and nucleic acid synthetic ratio, the generation of the immune materials such as enhancing antibody, complement, interferon, lysozyme.

Radix Glycyrrhizae: sweet in the mouth; Property is put down.GUIXIN; Lung; Spleen; Stomach warp.God's spleen QI invigorating; Heat-clearing and toxic substances removing; Expelling phlegm for arresting cough; Relieving spasm to stop pain; Coordinating the actions of various ingredients in a prescription.Cure mainly weakness of the spleen and stomach; Fatigue and weakness; Shortness of breath and palpitation; Carbuncle sore tumefacting virus; Alleviate aerosol toxicity.< < Compendium of Materia Medica > > carries: " control 72 kinds of mammary calculus poison, draft is malicious by every means to separate 1,002, is in harmonious proportion from medicine meritorious." modern medicine study confirmation; Radix Glycyrrhizae has stronger Detoxication; also have antiulcer, anti-inflammatory, spasmolytic antitussive, blood pressure lowering, blood fat reducing, antitumaous effect; be widely used in the diseases such as treatment pharyngolaryngitis, laryngitis, tracheitis, bronchitis, asthma, cough, hemoptysis, have in addition anti-gastric-ulcer, gastritis effect.

Radix Platycodonis: bitter in the mouth; Pungent; Property is put down.Return lung; Stomach warp.Lung qi dispersing; Eliminate the phlegm; Sore-throat relieving; Evacuation of pus.Cure mainly cough with copious phlegm; Laryngopharynx swelling and pain; Lung abscess vomiting pus; The full hypochondriac pain of born of the same parents.< < Japan hanako materia medica > > carries: " lower all gas, stop cramp caused by acute vomiting and diarrhea, and trusted subordinate's distending pain is mended five kinds of over strain; foster the spirit of nobility, evil removing is warded off temperature, tonify deficiency expectorant; by mass in the abdomen, and internal hemorrhage due to trauma and sore throat are mended in the evacuation of pus of nourishing blood." modern medicine study confirms, Radix Platycodonis, except sugar content is higher, also contains abundant vitamin B1, vitamin C etc., has phlegm-dispelling functions, and can reduce the content of cholesterol, increases the secretion of cholic acid, the effect such as antipyretic, analgesia in addition, antiinflammatory, calmness in addition.

Cortex Moutan: cold in nature, bitter in the mouth; Cool; Be slightly cold.GUIXIN; Liver; Kidney channel.Clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis; Send out speckle; Tell nosebleed; Carbuncle sore tumefacting virus.Modern medicine study proves, its extract has antibacterial anticoagulant, improve blood permeability, promote the effect of mononuclear phagocyte performance, the decomposition of the lipocyte due to resistance epinephrine, promote to add glucose in lipocyte and generate fat, increase the multiple effect that glucose due to insulin generates fat, treatment acute eczema is also had to remarkable effectiveness.

Poria: sweet in the mouth; Light; Property is put down.Enter the heart; Spleen; Lung; Kidney channel.Eliminating dampness and diuresis; Invigorating the spleen and regulating the stomach; Mind tranquilizing and the heart calming.Cure mainly edema distension; Phlegm retention cough with dyspnea; Insufficiency of the spleen lack of appetite; Let out wash with watercolours; Palpitation and restlessness; Insomnia forgetfulness.< < does not record > > and carries: " only quench one's thirst, large abdomen, drenches drop, the disease due to obstruction of QI of middle-JIAO expectorant water, and edema is drenched knot.Open breast internal organs, adjust visceral-qi, cut down kidney heresy, long cloudy, physical strength profiting, during guarantor god keeps." modern medicine study confirmation, Poria all has inhibitory action to staphylococcus aureus, escherichia coli, Bacillus proteus etc., can kill the antibacterials such as leptospira, and digestive system, blood system and central nervous system are had to certain protective effect.

radix Scrophulariae: sweet in the mouth; Bitter; Salty; Cold nature.Return lung; Stomach; Kidney channel.Clearing away heat and cooling blood; Nourishing YIN to lower pathogenic fire; Detoxicating and resolving stagnation of pathogens.Cure mainly warm febrile disease; Fever of the body; Excessive thirst; Crimson tongue; Hectic fever due to YIN-deficiency chronic cough; Fidgets due to deficiency is awake not; Constipation is hindered in Tianjin; Laryngopharynx swelling and pain; Scrofula sucutaneous nodule; Skin sore.< < Japan hanako materia medica > > carries: " control pyretic toxicity urticaria, tonify deficiency strain, the heart is frightened irritated, and bad weary hectic fever due to YIN-deficiency passes corpse pathogen, detumescence poison." modern medicine study confirmation, Radix Scrophulariae is containing Radix Scrophulariae element, iridoid glycosides, volatile oil, alkaloid etc., infusion, alcohol immersion and decoct have the effect of blood vessel dilating, heart tonifying, also have in addition town table and anticonvulsant action.

rhizoma Cyperi: acrid in the mouth; Cold nature; Nontoxic.Return liver; Lung; Spleen; Stomach; Tri-jiao channel.The resolving depression of regulating the flow of vital energy; Menstruction regulating and pain relieving.Cure mainly distending pain over the hypochondrium; Gastral cavity abdomen feeling of fullness pain; Belch acid regurgitation; Vomiting and nausea.< < detailed outline > > carries: " ulcer sores, spits blood; hematochezia, hematuria for the cold epidemic disease of loose seasonal epidemic pathogens, sharp three warmers, Xie Nvyu; the diet that disappears gathers; phlegm retention feeling of fullness, edema of dorsum of the foot, abdominal distention; beriberi; stop trusted subordinate, limbs, head, order, tooth, all pains of ear." modern medicine study proves, Rhizoma Cyperi has nervous system regulation effect, and has heart tonifying, decreased heart rate, reduces blood pressure, prevents and treats the effects such as hyperlipidemia and atherosclerosis.

cortex Magnoliae Officinalis: bitter in the mouth; Pungent; Warm in nature.Enter spleen; Stomach; Large intestine channel.Circulation of qi promoting removing food stagnancy; Dampness is except full; Lowering the adverse QI to relieve asthma.Cure mainly stagnation of QI due to dyspepsia; Abdominal distention constipation; Retention of dampness in middle-JIAO; Gastral cavity painful abdominal mass is vomited and diarrhoea; Expectorant is stopped up QI rising in reverse order; Fullness in the chest cough with asthma.< < does not record > > and carries: " warming middle-JIAO QI invigorating, the expectorant therapeutic method to keep the adverse QI flowing downwards.Treat cholera and stomachache distension, cold in the stomach is contrary and vomit in the heart incessantly, and let out dysentery and drench and reveal, except frightened, the earnest stuffy sensation with restlessness of going or staying, thick the intestines and stomach." modern medicine study confirmation, it is movable that Cortex Magnoliae Officinalis has the gastrointestinal of impact, antibacterial, antiviral, and antiallergic action, loose muscle, suppresses nervus centralis, antiallergic and the effect that maintains adjusting oral cavity bacterium.

fructus Aurantii Immaturus: bitter in the mouth; Pungent; Cold in nature.Enter spleen; Stomach; Liver; Heart channel.Dispelling the stagnated QI removing food stagnancy; Reduce phlegm except painful abdominal mass.Cure mainly in stagnant and stop; Feeling of fullness distending pain; Constipation; Heavy after dysentery; Blocked-up chest; Gastroptosis.< < medicineization justice > > carries: " Fructus Aurantii Immaturus is specially let out excess of the stomach, convinces hard knot by patient analysis, therefore the main middle part of gastric cavity is to control blood system; treat the interventral reality of umbilicus full, expectorant addiction, dispels and cut off the water; by dyspepsia, broken blocked-up chest, and relieving constipation is closed.Because of hematocele stagnant in, can not nutrition flesh table, if diet do not think, can not transporting because of spleen pent-up, all get power that its pungent loose hardship rushes down also.For the gas medicine in blood system, only this claims." Fructus Aurantii Immaturus can alleviate little enterospasm, increases gastrointestinal and shrinks the rhythm and pace of moving things, impels gallbladder contraction, increases Oddi's sphincter tension force, suppresses thrombosis, particularly has antiulcer effect.

the present invention compared with prior art, has following beneficial effect:

selected each medical material compatibility of the present invention is superior, and the property of medicine is mutually collaborative each other, gets the method in QI invigorating benefit, the regulate the flow of vital energy effect of resolving depression of tool, and the mechanism menstruction regulating and pain relieving for oral ulcer, has giving consideration to both the incidental and fundamental, effects a permanent cure and asks this advantage; Through Clinical Laboratory, good absorbing effect, evident in efficacy, safe and reliable, have no side effect and clinical adverse, recurrent oral ulceration is had to good curative effect.

The specific embodiment

below in conjunction with specific embodiment, the present invention is further elaborated.

embodiment 1

the raw material of aerosol effective ingredient of the present invention forms and weight is:

radix Rehmanniae 68g Radix Rehmanniae Preparata 68g Radix Paeoniae Alba 62g Rhizoma Atractylodis Macrocephalae 62g

radix Scutellariae 56g Radix Et Rhizoma Rhei 57g Radix Asparagi 53g 52g Radix Ophiopogonis

radix Glycyrrhizae 48g Radix Platycodonis 46g Cortex Moutan 45g Poria 49g

radix Scrophulariae 38g Rhizoma Cyperi 28g Cortex Magnoliae Officinalis 18g Fructus Aurantii Immaturus 14g

the processing step of production of aerosol of the present invention is:

(1) Rhizoma Cyperi, Fructus Aurantii Immaturus are stirred to micro-coke yellow that is with wheat bran, in the ratio of 10:10:1, get respectively Rhizoma Cyperi, Fructus Aurantii Immaturus, wheat bran, grind as smalls, cross 120 order fine powders, standby.

(2) Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Poria, Radix Scrophulariae are put into container, add the Ji Me Lao Jiu of triplication, hot digestion 2～3 hours, gets liquid; In remaining medicinal residues, add the Ji Me Lao Jiu of one times of amount, hot digestion 1～2 hour, gets liquid again; The liquid that boils that merges twice gained, the thick paste of simmer down to relative density 1.2～1.25 under 70 ℃ of temperature controls.

(3) Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Asparagi, Radix Ophiopogonis, Radix Glycyrrhizae, Radix Platycodonis, Cortex Moutan, Cortex Magnoliae Officinalis are put into container, add the water of four times of amounts, soak after 4～6 hours, get liquid; In remaining medicinal residues, add again the water of doubling dose, soak after 2～3 hours, get liquid; The medicinal liquid that merges twice gained, the thick paste of simmer down to relative density 1.15～1.20 under 60 ℃ of temperature controls.

(4) by after the thick paste mixing and stirring of the fine powder of step (1) gained and step (2), step (3) gained, be lyophilized into rapidly after powder, be prepared as aerosol.

usage and dosage: the damaged scope of viewport transmucosal and ulcer level, spray 9～18 every day, or spray during hurt like hell, within 2 days, be a course for the treatment of, common 1～2 course for the treatment of is effective, and pertinacious disease needs 3～4 courses for the treatment of.

embodiment 2

the raw material of aerosol effective ingredient of the present invention forms and weight is:

radix Rehmanniae 62g Radix Rehmanniae Preparata 62g Radix Paeoniae Alba 57g Rhizoma Atractylodis Macrocephalae 59g

radix Scutellariae 50g Radix Et Rhizoma Rhei 53g Radix Asparagi 47g 48g Radix Ophiopogonis

radix Glycyrrhizae 43g Radix Platycodonis 42g Cortex Moutan 42g Poria 45g

radix Scrophulariae 35g Rhizoma Cyperi 26g Cortex Magnoliae Officinalis 16g Fructus Aurantii Immaturus 10g

production of aerosol processing step and the usage and dosage of the present embodiment are identical with embodiment 1.

embodiment 3

the raw material of aerosol effective ingredient of the present invention forms and parts by weight are:

radix Rehmanniae 54g Radix Rehmanniae Preparata 57g Radix Paeoniae Alba 52g Rhizoma Atractylodis Macrocephalae 55g

radix Scutellariae 46g Radix Et Rhizoma Rhei 48g Radix Asparagi 43g 42g Radix Ophiopogonis

radix Glycyrrhizae 38g Radix Platycodonis 36g Cortex Moutan 38g Poria 40g

radix Scrophulariae 32g Rhizoma Cyperi 23g Cortex Magnoliae Officinalis 13g Fructus Aurantii Immaturus 8g

production of aerosol processing step and the usage and dosage of the present embodiment are identical with embodiment 1.

clinical data

oral ulcer lacks and can be used as the lab index of making a definite diagnosis foundation, with medical history and ulcer, show as diagnosis basis, the clinical aerosol curative effect of the present invention record that sprays shows, in the 215 routine symptoms case that suddenly slow, site of pathological change is neither identical, patient's sensation of pricking can be slowed down rapidly conventionally, ulcer symptom is compared with body spontaneous recovery, and cure time shortens 4～7 days, reaches the standard of clinical large-area applications completely.

Claims (3)

1. an aerosol for the treatment of recurrent oral ulceration, is characterized in that: raw material composition and the parts by weight of making described aerosol effective ingredient are:

50～65 parts of 50～65 parts of Rhizoma Atractylodis Macrocephalaes of 50～70 portions of Radix Paeoniae Albas of 50～70 parts of Radix Rehmanniaes Preparata of the Radix Rehmanniae

40～55 parts of 45～60 parts of Radix Asparagis of 45～60 parts of Radix Et Rhizoma Rhei of Radix Scutellariae 40～55 parts of Radix Ophiopogonis

35～50 parts, 35～50 parts of Poria of 35～50 parts of Cortex Moutans of 35～50 parts of Radix Platycodoniss of Radix Glycyrrhizae

6～15 parts of 10～20 parts of Fructus Aurantii Immaturuss of 20～30 parts of Cortex Magnoliae Officinalis of 30～40 portions of Rhizoma Cyperis of Radix Scrophulariae.

2. a kind of aerosol for the treatment of recurrent oral ulceration according to claim 1, is characterized in that: the raw material of making described aerosol effective ingredient forms and parts by weight are:

52～60 parts of 52～60 parts of Rhizoma Atractylodis Macrocephalaes of 55～65 portions of Radix Paeoniae Albas of 55～65 parts of Radix Rehmanniaes Preparata of the Radix Rehmanniae

45～50 parts of 50～55 parts of Radix Asparagis of 50～55 parts of Radix Et Rhizoma Rhei of Radix Scutellariae 45～50 parts of Radix Ophiopogonis

40～45 parts, 40～45 parts of Poria of 40～45 parts of Cortex Moutans of 40～45 parts of Radix Platycodoniss of Radix Glycyrrhizae

8～12 parts of 13～18 parts of Fructus Aurantii Immaturuss of 23～27 parts of Cortex Magnoliae Officinalis of 32～36 portions of Rhizoma Cyperis of Radix Scrophulariae.

3. a kind of aerosol for the treatment of recurrent oral ulceration according to claim 1, is characterized in that: the raw material of making described aerosol effective ingredient forms and parts by weight are:

55 parts of 55 parts of Rhizoma Atractylodis Macrocephalaes of 60 portions of Radix Paeoniae Albas of 60 parts of Radix Rehmanniaes Preparata of the Radix Rehmanniae

47 parts of 53 parts of Radix Asparagis of 52 parts of Radix Et Rhizoma Rhei of Radix Scutellariae 48 parts of Radix Ophiopogonis

42 parts, 43 parts of Poria of 43 parts of Cortex Moutans of 41 parts of Radix Platycodoniss of Radix Glycyrrhizae

9 parts of 15 parts of Fructus Aurantii Immaturuss of 24 parts of Cortex Magnoliae Officinalis of 33 portions of Rhizoma Cyperis of Radix Scrophulariae.