CN1803169A - Medicinal composition for treating leukaemia - Google Patents
Medicinal composition for treating leukaemia Download PDFInfo
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- CN1803169A CN1803169A CNA2005100608821A CN200510060882A CN1803169A CN 1803169 A CN1803169 A CN 1803169A CN A2005100608821 A CNA2005100608821 A CN A2005100608821A CN 200510060882 A CN200510060882 A CN 200510060882A CN 1803169 A CN1803169 A CN 1803169A
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Abstract
The invention discloses a pharmaceutical composition for treating leukemia, which comprises codonopsis pilosula 16-33 weight parts, white atractylodes rhizome 8-15 weight parts, poria cocos wolf 8-15 weight parts, Chinese angelica root 20-33 weight parts, rhizome of Sichuan lovage 3-6 weight parts, white peony root 8-15 weight parts, prepared rehmannia root 18-33 weight parts, rheum officinale 3-6 weight parts, tuber of multiflower knotweed 18-33 weight parts, orpiment 3-8 weight parts, natural indigo 3-6 weight parts, peanut coat 3-6 weight parts, and prepared licorice root 3-6 weight parts, wolfberry fruit 8-15 weight parts, negundo chastetree fruit 6-16 weight parts, rhinoceros horn powder 0.3-1.5 weight parts, and buffalo horn 20-33 weight parts.
Description
Technical field
The present invention relates to Chinese medicine preparation, the leukemic Chinese medicine pharmaceutical composition of specifically a kind of treatment.
Background technology
Leukemia claims leukemia again, belongs to multi-pathogenesis, many diseases, multifaceted complexity disease, leukemic pathology, medical knowledge and pharmacological research and clinical treatment thereof be at present both at home and abroad, one of the forward position research project of Chinese and western medicine.
Doctor trained in Western medicine is to leukemic present Research
The western medical treatment hematopathy has roughly experienced several stages such as blood transfusion, change-blood, chemotherapy, bone marrow transplantation, stem cell transplantation.But owing to cause of disease multiformity has caused occurring the state of an illness repeatedly and a large amount of complication in therapeutic process, individual immunity power descends, and remission rate is low, therapeutic effect is poor, problems such as treatment cost costliness.
1, chemotherapy.Chemotherapy is that at present both at home and abroad western medical treatment is leukemic must be through means and modal method.Be cancerous cell to be controlled, killed, make the state of an illness be controlled, alleviate by supporting treatment again by the chemical medicine of doses.As chemotherapy medicine cyclophosphamide, left-handed asparagine, daunorubicin, cytosine arabinoside, brave and fierce, Green's prestige etc.But these chemicals are not clear the human body internal target, when eliminating cancerous cell, also a large amount of good cells eliminated together, cause the function of human body eight big systems to destroy and disorder simultaneously, a lot of complication occur.And relapse rate still is 60%.According to investigations, most leukaemics die from leukemia, but die from the complication that causes thus.
The United States Medicine professor that Ceng Erci wins Nobel Prize is known as father's Linus of world's chemotherapy. Pauling professor write in " cancer and vitamin C " the 69th page of the 1st row: " if this treatment continues; then before tumor is not also eliminated; just the patient to having been killed, this has been the fact clearly.”
" cancer and vitamin C " (U.S.) Linus. Pauling, she is ten thousand years old. Cameron---select from scientific popularization publishing house and published standard book number: 14051*1084 in 1987.
2, bone marrow transplantation.Bone marrow transplantation is the leukemic new method of treatment that the eighties is risen, and has played certain positive role in the treatment leukemia, has also alleviated many leukaemics.But also exist and much be difficult to the problem that overcomes:
The one, the bone marrow pairing is difficult, and China does not have the bone marrow storehouse of certain scale, makes patient's treatment source be difficult to solve.According to data, the quantity that the bone marrow storehouse of present China mainland has does not also have Taiwan many.
The 2nd, patient's rejection is big, causes success rate low.The success rate various places of bone marrow transplantation report is all 40%-70% (condition according to various places hospital is different with level, and there is some difference) at present.
The 3rd, disease relapse appears again in the patient after many transplanting.Still can not thoroughly alleviate disease.
The 4th, the cost of transplanting is too high, and China's transplant operation is taken tens0000 yuan at least, and many two, 300,000 yuan, the basic financial insolvency of general patient.
3, stem cell transplantation.Stem cell transplantation is at present domestic and international medical research forward position, is by after cultivating through purification from the hematopoietic cell of body and allosome, remigrates in patient's body, reaches normal hemopoietic function.But still there are a lot of problems.As treat the patient and whether can reappear problems such as the transformation of stem cell division process, deformity, hypertrophy, apoptosis, source of human stem cell and to transplant cost also be two hang-ups that perplex equally medical circle or the like simultaneously.
Summary of the invention
The objective of the invention is to overcome the deficiency of prior art, provide a kind of new treatment leukemic Chinese medicine pharmaceutical composition.
Purpose of the present invention can take following method to realize:
The leukemic pharmaceutical composition of a kind of treatment is characterized in that it is that component is formed or made active component and pharmaceutically acceptable additives are formed or make powder, the watered pill, honeyed pill, granule, effervescent granule, capsule, the injection that active component and pharmaceutically acceptable additives are formed by the alcohol extract of following main materials by the water extract of following main materials by following main materials:
Radix Codonopsis 16～33 weight portions, the Rhizoma Atractylodis Macrocephalae 8～15 weight portions, Poria 8～15 weight portions,
Radix Angelicae Sinensis 20～33 weight portions, Rhizoma Chuanxiong 3～6 weight portions, the Radix Paeoniae Alba 8～15 weight portions,
Radix Rehmanniae Preparata 18～33 weight portions, Radix Et Rhizoma Rhei 3～6 weight portions, the Radix Polygoni Multiflori 18～33 weight portions,
Fructus Viticis Negundo 6～16 weight portions, Realgar 3～8 weight portions, Indigo Naturalis 3～6 weight portions,
Testa arachidis hypogaeae 3～6 weight portions, Radix Glycyrrhizae Preparata 3～6 weight portions, Fructus Lycii 8～15 weight portions,
Cornu rhinocerotis powder 0.3～1.5 weight portion or Cornu Bubali 20～33 weight portions.
Purpose of the present invention can also take following method to realize:
Described formula optimization is:
Radix Codonopsis 30 weight portions, the Rhizoma Atractylodis Macrocephalae 10 weight portions, Poria 10 weight portions, Radix Angelicae Sinensis 30 weight portions,
Rhizoma Chuanxiong 3 weight portions, the Radix Paeoniae Alba 10 weight portions, Radix Rehmanniae Preparata 20 weight portions, Radix Et Rhizoma Rhei 3 weight portions,
The Radix Polygoni Multiflori 30 weight portions, Realgar 3 weight portions, Indigo Naturalis 3 weight portions, Fructus Viticis Negundo 10 weight portions,
Testa arachidis hypogaeae 3 weight portions, Radix Glycyrrhizae Preparata 3 weight portions, Fructus Lycii 15 weight portions, Cornu Bubali 30 weight portions.
Described pharmaceutically acceptable additives are following one or more: soybean oil, Oleum Sesami, starch, sucrose, stevioside, citric acid, sodium bicarbonate, dextrin, lactose, micropowder silica gel, microcrystalline Cellulose, Na-alginate, tartaric acid, magnesium stearate.
The present invention uses China's Traditional Chinese medical theory, start with from " heat-clearing and toxic substances removing, adjusting and runing yang ", make full use of China's Chinese medicine treasure-house resource, from thousands of kinds of Chinese crude drugs, filtered out 16 kinds of Chinese medicines, formed hundred patients of treatment leukemia new drug given and brought positive effect through the science process of preparing Chinese medicine, refine.To the acute lymphoblastic leukemia, acute myeloblastic leukemia has very significant curative effect through clinical practice for many years.
According to statistics: treat 253 people, make in year from 3 years old to 68 years old, male 146 people, women 107 people, effective percentage 231 people, invalid 22 people, complete remission rate 91.3%, operate as normal is lived, and the patient reaches 72% more than 3 years.
Table one: domestic Chinese medicine and the present invention preferably treats the contrast of back complete remission rate to the acute leukemia curative effect
| Medicine: | (alltrans) retinoic acid, | Arsenic trioxide, | The present invention |
| The result: | 85.0％ | 52.3-73.3％ | 91.3％ |
Table two: the present invention treats the leukemia curative effect and divides the folding catalog:
| Sum | Effectively | Invalid | Produce effects | Cure | Complete remission rate | |
| The male: | 146 people | 133 | 13 | 128 | 65 | 91.3％， |
| The women: | 107 people | 98 | 9 | 92 | 52 | 91.5％ |
Table three: Drug therapy of the present invention bone marrow report (complete remission rate CR) after 8 weeks: annotate 1
| Before the treatment, | 2-3 after week in the treatment, | After treatment 8 weeks of back | ||||
| Former grain | Early young grain | Former grain | Early young grain | Former grain | Early young grain | |
| Example 1 ancient so-and-so | 6 | 82 | 3 | 15 | 0.5 | 4.0 |
| Example 2 Xue so-and-so | 0 | 81 | 0 | 8 | 0 | 3.0 |
| Example 3 grandsons so-and-so | 2 | 16* | 4 | 7 | 1 | 2.5 |
| Example 4 Zou | 2 | 77 | (because of not passing through chemotherapy, do not do midway bone marrow pick up look into) | 1.0 | ||
| Example 5 Lee so-and-so, | 12.4 | 80.4 | 1.0 | 22.5 | 0.8 | 2.4 |
Annotate: * is because of after recurring chemotherapy, and the bone marrow report is not seen during recurrence, after these data are chemotherapy.
1, patient's time-to-live is long.21 years have been reached with leukaemic's survival of the present invention's treatment is the longest at present, 231 people of survival more than 3 years, 213 people of survival more than 5 years, 97 people of survival more than 10 years.
2, captured an infertile great difficult problem after patient's chemotherapy.As everyone knows, obstacles such as after the chemotherapy, human body gene DNA easily misplaces, distorts, disconnected position cause sterility and infertility or fetal anomaly.And with after the present invention treatment, not only gene can not be encroached on, and can also repair the DNA damage that causes after the chemotherapy simultaneously, and be not affected patient's fertility, and child's intelligence of fertility, body constitution etc. are all no abnormal.
The model case of giving birth to after the female patient chemotherapy:
Example one: ancient so-and-so, the woman, 31 years old now, people from Mudanjiang City, Heilungkiang, on April 28th, 1988 was diagnosed as acute leukemia by Mudanjiang Medical College, after the present invention treats 1 year, alleviated fully.And in marriage in 91 years, 92 years life one boys (existing child 13 years old).
Example two: Xue so-and-so, the woman, 36 years old now, the fragrant spring people in Anhui and county was diagnosed as acute leukemia by attached drum tower hospital of Nanjing Medical University in 1991, took medicine of the present invention and got well after seven months.In life on October 12nd, 1,994 one boy (existing child 11 years old).
Example three: grandson so-and-so, the woman, 30 years old now, Henan Meng Zhoushi people was diagnosed as acute leukemia in 1996, chemotherapy is alleviated recurrence again after half a year, through taking nine first quarter moon rehabilitations of medicine of the present invention, and in a lifes boy (showing child 6 years old) in 1999.
Example four: Zhang, the woman, 29 years old now, people from Huixian City, Henan was diagnosed as aplastic anemia by the People's Hospital, Jiaozhuo, Henan in 1996, took medicine of the present invention after six months, in life one boy (existing child 6 years old) in 1999.
Example five: Zou, woman, 26 years old now, the fragrant spring people in Anhui and county.Be diagnosed as acute leukemia through drum tower the People's Hospital, the attached Nanjing of Nanjing Medical University in 03 year.Platelet only 8000 at that time, and critical very much, school repeatedly sends the notice of being critically ill, through recovering normal after 1 year 03 months with Drug therapy of the present invention.The inventor paid a return visit to fragrant spring on March 22nd, 2005, learnt that Zou was in life one boy (existing child 1 years old) in 2004.
The present invention has following several characteristics:
1. prescription science.According to different cases, adopt 16 kinds of Chinese medicines to be mixed with preparation series, control many sick different controlling until different disease more.
2. it is unique to concoct.Can extract the Chinese medicine elite, and remove oxious component, make medicine safer effectively, simultaneously taking convenience.
3. treating both the principal and secondary aspects of a disease, heat-clearing and toxic substances removing, adjusting and runing yang.Can eliminate the disease focus fast, vital base and primordial QI consolidating improves the human body resistance against diseases comprehensively simultaneously, makes the state of an illness reach radical cure and no longer recurrence.
4. medicinal cost is lower, and general every month expenses for medicine of patient is taken 6-10 and got final product in individual month, just: change about 10,000 yuan and can cure leukemia about 1200 yuan.
5. safe and effective, a large amount of clinical observations of medicine of the present invention show efficient, low toxicity.
The specific embodiment
Describe embodiment of the present invention below in detail.
Embodiment 1: get
Radix Codonopsis 3000 restrains, the Rhizoma Atractylodis Macrocephalae 1000 restrains, Poria 1000 restrains, Radix Angelicae Sinensis 3000 restrains, Rhizoma Chuanxiong 300 restrains, the Radix Paeoniae Alba 1000 restrains,
Radix Rehmanniae Preparata 2000 restrains, Radix Et Rhizoma Rhei 300 restrains, the Radix Polygoni Multiflori 3000 restrains, Fructus Viticis Negundo 1000 restrains, Realgar 300 restrains, Indigo Naturalis 300 restrains,
Testa arachidis hypogaeae 300 grams, Radix Glycyrrhizae Preparata 300 grams, Fructus Lycii 1500 grams, Cornu Bubali 3000 grams.
After above medicine chosen carefully, remove impurity, dry, sterilization, be ground into the superfine end of 200 orders with pulverizer, add a kind of or several additives soybean oils, Oleum Sesami, starch, sucrose, stevioside, citric acid, sodium bicarbonate, dextrin etc., be processed into pill, pill can be made the common watered pill or honeyed pill.For sugared type or Sugarless type are arranged.
Embodiment 2: get
Radix Codonopsis 1600 restrains, the Rhizoma Atractylodis Macrocephalae 800 restrains, Poria 800 restrains, Radix Angelicae Sinensis 2000 restrains, Rhizoma Chuanxiong 300 restrains, the Radix Paeoniae Alba 800 restrains,
Radix Rehmanniae Preparata 1800 restrains, Radix Et Rhizoma Rhei 300 restrains, the Radix Polygoni Multiflori 1800 restrains, Fructus Viticis Negundo 600 restrains, Realgar 300 restrains, Indigo Naturalis 300 restrains,
Testa arachidis hypogaeae 300 grams, Radix Glycyrrhizae Preparata 300 grams, Fructus Lycii 1500 grams, Cornu Bubali powder 3000 grams.
Above medicine pulverize separately is become coarse powder, decoct with water 2-3 time, each 1-3 hour, filter; Merging filtrate is concentrated into relative density 1.10～1.40 (55～60 ℃), adds ethanol and reaches 50% to containing the alcohol amount, leaves standstill 24 hours; Filter, filtrate recycling ethanol is concentrated into relative density 1.35～1.38 (55～60 ℃) thick paste, and vacuum drying is ground into fine powder, adds appropriate amount of auxiliary materials, and mixing is granulated, and is pressed into 1000, and sugar coating promptly gets tablet.
Embodiment 3: get
Radix Codonopsis 3300 grams, the Rhizoma Atractylodis Macrocephalae 1500 grams, Poria 1500 grams, Radix Angelicae Sinensis 3300 restrain, Rhizoma Chuanxiong 600 restrains,
The Radix Paeoniae Alba 1500 grams, Radix Rehmanniae Preparata 3300 grams, Radix Et Rhizoma Rhei 600 grams, the Radix Polygoni Multiflori 3300 restrain, Fructus Viticis Negundo 1600 restrains,
Realgar 800 grams, Indigo Naturalis 600 grams, Testa arachidis hypogaeae 600 grams, Radix Glycyrrhizae Preparata 600 restrain, Fructus Lycii 1500 restrains,
Cornu Bubali 2000 grams.
Above medicine respectively 80～105 ℃ of oven dry, is made moisture≤8%, pulverize, cross sieve No. one.Press solid-liquid ratio 1: 5～10,60～98 ℃ of following floodings of temperature 3～12 hours, repeat twice, filter and remove residue is got supernatant, merging filtrate.Filtrate sucks vacuum concentration pot, under 0.04～0.08MPa vacuum, be concentrated into material heavy 1/2～3/4.Concentrate feed carries out spray drying, 160～180 ℃ of spray drying control inlet temperature, 70～85 ℃ of leaving air temps, but the dry product direct packaging becomes powder, makes dissolved granule after also can sneaking into inserts such as dextrin, maltodextrin, cyclodextrin, soluble starch etc.
Embodiment 4: get
Radix Codonopsis 3000 grams, the Rhizoma Atractylodis Macrocephalae 1000 grams, Poria 1000 grams, Radix Angelicae Sinensis 3000 restrain, Rhizoma Chuanxiong 300 restrains,
The Radix Paeoniae Alba 1000 grams, Radix Rehmanniae Preparata 2000 grams, Radix Et Rhizoma Rhei 300 grams, the Radix Polygoni Multiflori 3000 restrain, Fructus Viticis Negundo 1000 restrains,
Realgar 300 grams, Indigo Naturalis 300 grams, Testa arachidis hypogaeae 300 grams, Radix Glycyrrhizae Preparata 300 restrain, Fructus Lycii 1500 restrains,
Cornu Bubali 3000 grams.
After medicine-feeding chosen carefully, remove impurity, be ground into the superfine end of 200 orders with pulverizer, add a kind of or several additives soybean oils, Oleum Sesami, starch, sucrose, stevioside, citric acid, sodium bicarbonate, dextrin etc., be processed into granule, granule can be plain particles, effervescent granule, and sugared type or Sugarless type can be arranged.
Embodiment 5: get
Radix Codonopsis 3000 grams, the Rhizoma Atractylodis Macrocephalae 1000 grams, Poria 1000 grams, Radix Angelicae Sinensis 3000 restrain, Rhizoma Chuanxiong 300 restrains,
The Radix Paeoniae Alba 1000 grams, Radix Rehmanniae Preparata 2000 grams, Radix Et Rhizoma Rhei 300 grams, the Radix Polygoni Multiflori 3000 restrain, Fructus Viticis Negundo 1000 restrains,
Realgar 300 grams, Indigo Naturalis 300 grams, Testa arachidis hypogaeae 300 grams, Radix Glycyrrhizae Preparata 300 restrain, Fructus Lycii 1500 restrains,
Cornu Bubali 3000 grams.
After medicine-feeding chosen carefully, remove impurity, be ground into the superfine end of 200 orders with pulverizer, add a kind of or several additives soybean oils, Oleum Sesami, starch, sucrose, stevioside, citric acid, sodium bicarbonate, dextrin etc., be processed into drop pill, micropill or various pill, wherein micropill is taken in can directly taking and also can incapsulating.Sugared type or Sugarless type can be arranged.
Embodiment 6: get
Radix Codonopsis 3000 grams, the Rhizoma Atractylodis Macrocephalae 1000 grams, Poria 1000 grams, Radix Angelicae Sinensis 3000 restrain, Rhizoma Chuanxiong 300 restrains,
The Radix Paeoniae Alba 1000 grams, Radix Rehmanniae Preparata 2000 grams, the Radix Et Rhizoma Rhei 300 gram Radixs Polygoni Multiflori 3000 restrain, Fructus Viticis Negundo 1000 restrains,
Realgar 300 grams, Indigo Naturalis 300 grams, Testa arachidis hypogaeae 300 grams, Radix Glycyrrhizae Preparata 300 restrain, Fructus Lycii 1500 restrains,
Cornu Bubali 3000 grams.
After medicine-feeding chosen carefully, remove impurity, be ground into the superfine end of 300 orders, add a kind of or several additives soybean oils, Oleum Sesami, starch, sucrose, stevioside, citric acid, sodium bicarbonate, dextrin etc., take in can incapsulating with pulverizer.
Embodiment 7: get
Radix Codonopsis 1600 grams, the Rhizoma Atractylodis Macrocephalae 800 grams, Poria 800 grams, Radix Angelicae Sinensis 2000 restrain, Rhizoma Chuanxiong 300 restrains,
The Radix Paeoniae Alba 800 grams, Radix Rehmanniae Preparata 1800 grams, Radix Et Rhizoma Rhei 300 grams, the Radix Polygoni Multiflori 1800 restrain, Fructus Viticis Negundo 600 restrains,
Realgar 300 grams, Indigo Naturalis 300 grams, Testa arachidis hypogaeae 300 grams, Radix Glycyrrhizae Preparata 300 restrain, Fructus Lycii 1500 restrains,
Cornu Bubali 3000 grams.
Above medicine pulverize separately is become coarse powder, decoct with water 2-3 time, each 1-3 hour, filter; Merging filtrate.Make injection by the injection processing technique.
Embodiment 8: get
Radix Codonopsis 1600 grams, the Rhizoma Atractylodis Macrocephalae 800 grams, Poria 800 grams, Radix Angelicae Sinensis 2000 restrain, Rhizoma Chuanxiong 300 restrains,
The Radix Paeoniae Alba 800 grams, Radix Rehmanniae Preparata 1800 grams, Radix Et Rhizoma Rhei 300 grams, the Radix Polygoni Multiflori 1800 restrain, Fructus Viticis Negundo 600 restrains,
Realgar 300 grams, Indigo Naturalis 300 grams, Testa arachidis hypogaeae 300 grams, Radix Glycyrrhizae Preparata 300 restrain, Fructus Lycii 1500 restrains,
Cornu Bubali 3000 grams.
After medicine-feeding chosen carefully, remove impurity, be ground into the superfine end of 300 orders, add a kind of or several additives soybean oils, Oleum Sesami, starch, sucrose, stevioside, citric acid, sodium bicarbonate, dextrin etc., make powder, directly take with pulverizer.
Application examples: case
Case one:
Zou, woman, 26 years old now, the fragrant spring people in Anhui and county.Be diagnosed as acute leukemia through Nanjing Medical University attached drum tower the People's Hospital in 03 year.Platelet only 8000 at that time, and critical very much, school repeatedly sends the notice of being critically ill, through recovering normal after 1 year 03 months with Drug therapy of the present invention.
Case two:
Peng so-and-so, the man, 31 years old, sub-Zhou Qianzhou people from village raised in the suburbs, Nanchang.The patient suffers from acute myeloblastic leukemia in February, 1985 and lives in Children's Hospital, Jiangxi Prov., treats and obtains the part alleviation after three months.The recurrence again after the several months of leaving hospital is lived the children's hospital into province once again on May 12nd, 1985, and at that time a nearly week of hyperpyrexia, medication was invalid.After taking medicine of the present invention, the body temperature drop was to normal in three days.Seriously festering of oral cavity during to the 6th day, fully recovered.After five Drug therapys of the present invention of surplus month that this example is shared, blood picture and bone marrow recover: hematochrome 11.7 grams, erythrocyte 4,000,000, leukocyte 6900, platelet more than 100,000,20 years till now.
Case three:
Hu, man, 55 years old, Anhui and the work of Xian Xi port country government.The patient suffers from acute myeloblastic leukemia in December, 1988.Through total institute of Nanjing Military Command treatment 1 year, obtained alleviation, but the people is weak.Erythrocyte 2,700,000, leukocyte 2300.After I adopted Drug therapy ten wheat harvesting periods of the present invention, the blood picture myelogram all returned to normally, now worked life, the no any discomfort of work 17 years.
Case four:
Guo, the man, 23 years old, be only 7 years old in 1989 he suffered from acute leukemia.Find cancerous cell 56.5% in the bone marrow blood examination of the big attached Zhengzhou of Nikkei Henan medical courses in general in April 9 nineteen ninety the 3rd hospital, leukocyte only 100, platelet 1.2 ten thousand has been in high-risk dangerous situation.After taking seven months Drug therapy of the present invention, health recovers fully, and drafts in 1999,16 years till now.
Case five:
Guo so-and-so, woman, 18 years old, Anhui Chu Zhoushi people.Live attached children's hospital because of suffering from acute lymphatic leukemia in the time of 3 years old into Nanjing Medical University.Guo his father appoints the English Instructor in Chu Zhou city six, certain appoints the secretary of the Party committee in cement plant, Chu Zhou city its female left side.Patient's platelet 3.1 ten thousand, leukocyte 1.56 ten thousand have at that time been done blood picture after nine months and bone is worn inspection with medicine of the present invention, and health recovers fully, 16 years till now.
Case six:
Lee so-and-so, man, 43 years old, the Henan Jiaozuo City cadre of the institute of agricultural sciences.Suffer from acute leukemia in February, 92 through the Jiaozuo City the People's Hospital.Leukocyte 2.52 ten thousand in February 28 peripheral blood, platelet 6.7 ten thousand, juvenile cell 72%.February 22, bone inspection Central Plains children's grain 92.4%.After Drug therapy of the present invention, cure fully.Patient's orthobiosis, work always during the last ten years, body constitution is stronger before ill, 13 years till now.
Case seven:
Guo so-and-so, man, 55 years old now, the sliding Feng Cunren in Wuzhi County, Henan east.Be diagnosed as chronic myelocytic leukemia (acute transformation phase) through Jiaozuo City second the People's Hospital in 2000.Behind Drug therapy 10 wheat harvesting periods of the present invention, physical recovery is normal, and makes business outside, 5 years till now.
Case eight:
Hao so-and-so, woman, 55 years old now, the worker of Jiaozhuo, Henan chain factory.Be diagnosed as acute leukemia through the bone inspection of Henan medical courses in general big one attached institute in February, 1993.Obtain alleviation fully after five months through chemotherapy.But in late July state of an illness appearance recurrence.After nearly 1 year of the Drug therapy of the present invention, on June 13rd, 94, blood picture recovered normal: hematochrome 14.8 grams, erythrocyte 5,200,000, leukocyte 7800, platelet 230,000,12 years till now.
Case nine:
The king so-and-so, woman, 56 years old now, Nanjing welfare center for children work.Nikkei Jiangsu Prov. People's Hospital bone inspection in April 13 in 94 year is diagnosed as acute leukemia, former children's grain 62%.After the chemotherapy, still undesirable.Through taking Drug therapy of the present invention after seven months, all recover normal, 11 years till now.
Case ten:
Zhang, man, 25 years old now, people from Lushan County, Henan.His father Zhang is the factory director of Lushan chemical fertilizer factory.In June, 94, the patient was 15 years old, was diagnosed as acute myeloblastic leukemia through one attached institute of Henan Medical Univ..Obtaining part after the chemotherapy alleviates.But routine blood test is undesired.Take Drug therapy of the present invention after 8 months, 11 years till now.
Case 11:
Zhao so-and-so, woman, 2 years old, people from Mudanjiang City, Heilongjiang Province.Be diagnosed as acute leukemia through Affiliated Hospital of Mudanjiang Medical College in 1994.On October 21st, 94 hematochrome 3.6 gram, leukocyte 1600, platelet 3.6 ten thousand.Juvenile cell (cancerous cell) 92.4%.Take Drug therapy of the present invention after 1 year, the blood examination on October 27th, 95: hematochrome 10.7 gram, erythrocyte 3,740,000, leukocyte 4000, platelet 14.2 ten thousand returns to one's perfect health, 11 years till now.
Case 12:
Xu Liya, woman, 47 years old now, jiangsu wuxi people from city.Work in Dajishan Tool and Equipment Factory, Wuxi City.In JIUYUE, 91 is diagnosed as acute leukemia through the Jiangsu Prov. People's Hospital.After taking ten months Drug therapy of the present invention, all were normal in 93 years working backs, 15 years till now.
Case 13:
Zhang, woman, 64 years old now.Jiangsu wuxi city Nanzhang District people from village that become famous.The incumbent grade teacher that becomes famous.Calendar year 2001 economizes second the People's Hospital through Wuxi City and is diagnosed as chronic myelocytic leukemia.Through Drug therapy of the present invention more than a year, existing all are normal, 5 years till now.
Case 14:
Lee so-and-so, woman, 20 years old now, Wu villages and small towns, Huixian City, Henan people from Xiaozhuang village.With case 13 Chen families 100 meters distant only.Be only 6 years old in June, 1991, is diagnosed as the single leukemia of anxious grain through Jiaozuo City second the People's Hospital.(M4 type) through recovering after 8 months normally with Drug therapy of the present invention, 14 years till now.
Case 15:
Feng so-and-so, man, 51 years old now.Jiaozhuo, Henan section chief of sales section of chemical pharmaceutical factory.In August nineteen ninety-five, First People's Hospital is diagnosed as acute leukemia through Jiaozuo City.Behind 7 first quarter moons of Drug therapy of the present invention, rehabilitation all normally 10 years so far.
Case 16:
Zhai so-and-so, man, 38 years old now.Yixing, Jiangsu people from county.Incumbent Yixing City is handled with prosperous Industrial Co., Ltd..Nineteen ninety-five is diagnosed as acute myeloblastic leukemia through the Zong Yuan of Nanjing Military Command.Drug therapy of the present invention was resumed work in 97 years after 1 year, and it's going fine so far, 10 years till now.
Case 17:
Pay so-and-so, woman, 49 years old now, so-and-so lover of Lee of Zhengzhou City, Henan Shangjie District hardware, electrical and chemical equipment company.The patient was diagnosed as MDS through Affiliated Hospital of Henan Medical Univ. in 1999, i.e. the bone marrow abnormal syndrome.Through Drug therapy of the present invention after ten months, all recover normal, work every day more than ten hour, feel good, 6 years till now.
Case 18:
Liu so-and-so, woman, 42 years old now, Wu villages and small towns, Huixian City, Henan Tuan Xiang people from village.Be diagnosed as myelodysplastic syndrome through the Zong Yuan of mineral bureau of Jiaozuo City central authorities in August, 1996 is MDS.After ten months, recover normal through Drug therapy of the present invention.I pay a return visit in its family on May 12nd, 2005, and Liu Yuping works down on the farm, and all are normal, 9 years till now.
Case 19:
What so-and-so, man, 42 years old now, people from county of Lingbao City, Henan.Zhengzhou Zheng Fei company work now.Be diagnosed as acute leukemia through second the People's Hospital, Luoyang City, Henan in 97 years.After the nearly 1 year treatment of medicine of the present invention, return to one's perfect health.On May 15th, 2005, the inventor paid a return visit in the Zhengzhou City, 10 years till now.
Case 20:
Make pottery so-and-so, woman, 54 years old now, south, Qi Ligang township, Xinjian County, Jiangxi Province so-and-so wife of Zhao Jia village Zhao.Be diagnosed as acute leukemia through Jiangxi Hospital in 1992.Chemotherapy effect is not good, take the treatment of medicine 6 wheat harvesting periods of the present invention after, get well, now family is engaged in agriculture, 13 years till now.
Case 21:
Huang, woman, 14 years old now, Anhui Chu Zhoushi people.Be only she of 6 years old in 1997, after attached drum tower hospital of Nanjing Medical University was diagnosed as leukemia, takes the nearly 1 year treatment of medicine of the present invention, all recovered normal, 8 years till now.I paid a return visit to the Chu continent on March 25th, 2005.
Case 22:
Xu so-and-so, woman, 21 years old now, Pingdingshan City, Henan Xinhua District sun town Ji Zhuan people from village.1998, First People's Hospital, Pingdingshan City was diagnosed as acute leukemia.After the Drug therapy of the present invention in 1 year, all recover normal health, 7 years till now.
Case 23:
Xiao, the man, 27 years old now, in January, 1998, Zong Yuan was diagnosed as acute leukemia through Nanjing Military Command.Through the nearly 2 years treatment of medicine of the present invention, all recover normal, marry 7 years till now in January, 2005.
Case 24:
The king so-and-so, man, 23 years old now, six ore deposit, Pingdingshan City, Henan so-and-so son of supply station king.Be diagnosed as acute leukemia through Xinhua the People's Hospital, Pingdingshan City in 2000, after ten months, all are normal through Drug therapy of the present invention.Now junior college is read by table mountain mining metallurgical engineering institute, 5 years till now.
Case 25:
Lee so-and-so, woman, 20 years old now, Ye County, Henan Gong Dianxiang Chang Li people from village.Be diagnosed as acute leukemia through First People's Hospital, Pingdingshan City in 1998, after taking the Drug therapy of the present invention in 1 year, all are normal, 7 years till now.
Case 26:
Huangfu so-and-so, the man, 45 years old now, the Boai County, Henan open eat the collection village people.Be diagnosed as chronic myelocytic leukemia through the Jiaozuo City the People's Hospital in 1998.Through Drug therapy of the present invention more than a year, now return to one's perfect health, work, 7 years till now.
Claims (3)
1, the leukemic pharmaceutical composition of a kind of treatment is characterized in that it is that component is formed or made active component and pharmaceutically acceptable additives are formed or make powder, the watered pill, honeyed pill, granule, effervescent granule, capsule, the injection that active component and pharmaceutically acceptable additives are formed by the alcohol extract of following main materials by the water extract of following main materials by following main materials:
Radix Codonopsis 16～33 weight portions, the Rhizoma Atractylodis Macrocephalae 8～15 weight portions, Poria 8～15 weight portions,
Radix Angelicae Sinensis 20～33 weight portions, Rhizoma Chuanxiong 3～6 weight portions, the Radix Paeoniae Alba 8～15 weight portions,
Radix Rehmanniae Preparata 18～33 weight portions, Radix Et Rhizoma Rhei 3～6 weight portions, the Radix Polygoni Multiflori 18～33 weight portions,
Realgar 3～8 weight portions, Indigo Naturalis 3～6 weight portions, Testa arachidis hypogaeae 3～6 weight portions,
Radix Glycyrrhizae Preparata 3～6 weight portions, Fructus Lycii 8～15 weight portions, Fructus Viticis Negundo 6～16 weight portions,
Cornu rhinocerotis powder 0.3～1.5 weight portion or Cornu Bubali 20～33 weight portions.
2, pharmaceutical composition according to claim 1 is characterized in that formula optimization is:
Radix Codonopsis 16 weight portions, the Rhizoma Atractylodis Macrocephalae 10 weight portions, Poria 10 weight portions, Radix Angelicae Sinensis 30 weight portions,
Rhizoma Chuanxiong 3 weight portions, the Radix Paeoniae Alba 10 weight portions, Radix Rehmanniae Preparata 20 weight portions, Radix Et Rhizoma Rhei 3 weight portions,
The Radix Polygoni Multiflori 30 weight portions, Realgar 3 weight portions, Indigo Naturalis 3 weight portions, Testa arachidis hypogaeae 3 weight portions,
Radix Glycyrrhizae Preparata 3 weight portions, Fructus Lycii 15 weight portions, Cornu Bubali 30 weight portions.
3, pharmaceutical composition according to claim 1 is characterized in that: described pharmaceutically acceptable additives are following one or more: soybean oil, Oleum Sesami, starch, sucrose, stevioside, citric acid, sodium bicarbonate, dextrin, lactose, micropowder silica gel, microcrystalline Cellulose, Na-alginate, tartaric acid, magnesium stearate.
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| CNB2005100608821A CN100446795C (en) | 2005-09-21 | 2005-09-21 | Medicinal composition for treating leukaemia |
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| CNB2005100608821A CN100446795C (en) | 2005-09-21 | 2005-09-21 | Medicinal composition for treating leukaemia |
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| CN100446795C CN100446795C (en) | 2008-12-31 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101417078B (en) * | 2008-12-08 | 2011-04-06 | 涂金显 | Chinese herbal medicine preparation for treating leukaemia |
| CN101590091B (en) * | 2008-05-27 | 2012-08-08 | 北京因科瑞斯医药科技有限公司 | Traditional Chinese medicine combination for treating leukemia and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1348818A (en) * | 2001-11-05 | 2002-05-15 | 潘文光 | Leukemia treating granule capable of being used to replace chemotherapy and marrow transplantation |
| CN1216620C (en) * | 2002-08-06 | 2005-08-31 | 王凯 | Composite medicine for treating leukemia |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101590091B (en) * | 2008-05-27 | 2012-08-08 | 北京因科瑞斯医药科技有限公司 | Traditional Chinese medicine combination for treating leukemia and preparation method thereof |
| CN101417078B (en) * | 2008-12-08 | 2011-04-06 | 涂金显 | Chinese herbal medicine preparation for treating leukaemia |
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