CN1772098A - Chinese medicine composition for treating chronic pharyngitis and phlegm-heat and its prepn process - Google Patents
Chinese medicine composition for treating chronic pharyngitis and phlegm-heat and its prepn process Download PDFInfo
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Abstract
The present invention provides one kind of Chinese medicine composition for treating chronic pharyngitis and phlegm-heat causing pain throat, itching throat, dry throat and foreign body sensation. The Chinese medicine composition is compounded with figwort, rehmannia root, honeysuckle, forsythia, balloonflower root and other four kinds of Chinese medicinal materials as well as honey in certain weight proportion. The present invention has obvious antiphlogistic and analgetic functions, and clinical test proves its determined and high curative effect.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate to a kind of Chinese medicine composition and preparation method thereof, relate in particular to a kind of preparation technology who treats Chinese medicine composition and this Chinese medicine composition of chronic pharyngitis.
Background technology
Chronic pharyngitis, the traditional Chinese medical science claim " sore throat ".The main cause that causes chronic pharyngitis has: cigarette, wine are excessive; Contact has irritative gas; Dust and long-term mouth breathing; Dry; Speak too much; Or the heresy of obeying hot thing or wind heat loves for a long time in lung, the damage lung yin, and deficiency of YIN failing to restrain YANG is then seen the card of hyperactivity of fire caused by deficiency of YIN.The symptom of chronic pharyngitis is: pharyngeal discomfort, dry pharynx, pharynx hypodynia, foreign body in pharynx sense.Phlegm-heat patient's clinical symptoms is an abundant expectoration, cough, the pharynx rear wall has secretions to adhere to, this is a YIN-deficiency of the lung and kidney, hyperactivity of deficient fire, as the then pharyngeal drying of heresy of experiencing wind heat obviously, pharyngalgia increases the weight of and burning sensation is arranged.
Summary of the invention
The purpose of this invention is to provide and a kind ofly can effectively treat having sore throat due to sore throat yin deficiency or the phlegm-heat, itching throat, dry pharynx, foreign body sensation and by the Chinese medicine composition of above symptom due to the chronic pharyngitis.
Another object of the present invention provides the preparation technology of this Chinese medicine composition.
Chinese medicine composition of the present invention is to be prepared from by following materials of weight proportions:
35～75 parts of 20～60 portions of Flos Loniceraes of 25～75 portions of Radix Rehmanniae of Radix Scrophulariae
20～60 parts of 20～60 parts of Rhizoma Belamcandae of 25～75 parts of Radix Platycodoniss of Fructus Forsythiae
0.1～0.3 part of 16.5～49.5 parts of Borneolum Syntheticum of 20～60 portions of Radix Glycyrrhizaes of Radix Isatidis
275～825 parts of Mel.
Chinese medicine composition of the present invention is to be formed by following prepared:
1. with Radix Scrophulariae, Fructus Forsythiae, Radix Platycodonis, Radix Isatidis, Rhizoma Belamcandae, Radix Rehmanniae, Radix Glycyrrhizae with the water boiling and extraction of 5～15 times of amounts three times, each 1～3 hour extraction time, merge decoction liquor, filter;
2. be warm macerating three times in 50～90 ℃ of water with Flos Lonicerae 10～20 times of amounts, temperature, each 0.5～3 hour, merge warm macerating liquid, filter;
3. merge above-mentioned decoction liquor and warm macerating liquid, being evaporated to proportion is 1.06～1.08g/ml, filters;
4. in above-mentioned concentrated solution, add sterilized Mel, stir and make its mixing;
5. add Borneolum Syntheticum, stir, mix homogeneously must get the active component of medicine of the present invention.
The present invention can make mixture with the medicine activity component of producing.
The preparation technology of Chinese medicine composition mixture of the present invention is: in the medicine activity component of producing, add 0.2～0.6 part of antiseptic, and add water and make its concentration to 0.4 ‰-0.8 ‰, transfer PH to 4.1～5.0 with citric acid then, stir evenly, divide pack mixture.
Described antiseptic is an ethyl hydroxybenzoate.
The present invention can be pressed into tablet with medicine activity component and the tablet auxiliary materials and mixing of producing commonly used.
The preparation technology of Chinese medicine composition tablet of the present invention is: above-mentioned adding has been sterilized behind the concentrated solution vacuum drying or spray drying behind the Mel, be ground into fine powder, made granule with 40%～85% ethanol; Spray into the alcoholic solution of Borneolum Syntheticum after the drying, mixing, tabletting is shaped.
The alcoholic solution concentration of described Borneolum Syntheticum is 0.006～0.2g/ml.
The purposes of medicine of the present invention: be used for the treatment of chronic pharyngitis and phlegm-heat or by symptoms such as having sore throat due to chronic pharyngitis and the phlegm-heat, itching throat, dry pharynx, foreign body sensations.
Effective dose of medicine of the present invention: oral, a 20ml, 4 times on the one.20 days was 1 course of treatment.
Effect of the present invention can be proved absolutely by following experiment:
1. pharmacodynamic experiment: experiment has been carried out the pharmacodynamics investigation from antiinflammatory, analgesic, analgesia, antibacterial four aspects:
1.1: antiinflammatory action:
1.1.1 anti-Oleum Tiglii proinflammatory effect: compare with the normal saline matched group, heavy dose of group of mixture of the present invention (28g/kg) and salicylic acid group (0.3g/kg) all have significant anti-Oleum Tiglii proinflammatory effect (P＜0.05).
1.1.2 suppress the capillary permeability effect: hydrocortisone group (0.025g/kg), salicylic acid group all have the effect (P＜0.05) of significant inhibition mice capillary permeability increase to (0.03g/kg) and the heavy dose of group of mixture of the present invention (28g/kg).
1.1.3 the pedal swelling that on Carrageenan causes experiment shows: the heavy dose of group of mixture of the present invention (40g/kg) on Carrageenan proinflammatory effect a little less than, but tangible antiinflammatory tendency is arranged, and the hydrocortisone group just had significant antiinflammatory action (P＜0.05) in 4～6 hours after administration.
1.1.4 suppress the test of Mus granuloma induced by implantation of cotton pellets: compare with the normal saline group, mixture group of the present invention (20g/kgd) has the effect (P＜0.05) of significant inhibition Mus granuloma induced by implantation of cotton pellets, mixture group (40g/kgd) has the effect (P＜0.01) of the inhibition Mus granuloma induced by implantation of cotton pellets of highly significant, hydrocortisone (0.03g/kgd) has the effect (P＜0.01) of the inhibition Mus granuloma induced by implantation of cotton pellets of highly significant, and hydromel group and normal saline group are than there was no significant difference (P＞0.05).
1.2 analgesic test: show that by the hot plate method test mixture of the present invention has analgesic tendentiousness.Show by the writhing method test: the periphery pain that mixture Dichlorodiphenyl Acetate of the present invention causes has significant inhibitory effect (P＜0.05).
1.3 bacteriostatic test: mixture of the present invention has remarkable inhibitory action to six kinds of common bacterias such as bacillus pyocyaneus, proteus vulgaris, Flavobacterium, staphylococcus aureus, Candida albicans, pneumobacilluses.
1.4 separate heat test: show that by controlled trial mixture group of the present invention (33.7g/kg) more all has significant differences (P＜0.01) with other each groups in 0.5-2 hour after administration with hydromel group, aspirin group and distilled water group; Each group of mixture group (27g/kg) group and other is no significant difference relatively all.
2. acute toxicity test: because many effects limit such as administration concentration, administration volume can't be measured median lethal dose(LD 50) (LD50) value through prerun.Carry out maximum tolerated dose (MTD) determination test under the acceptable maximum volume of mice, the result records mice LD50 greater than the 72g/ kilogram, has been equivalent to 144 times of the clinical consumption of people, illustrates that toxicity is minimum, and is safe.
3. long term toxicity test: divide four groups: 100 times, 60 times, 30 times of clinical consumption and matched group are relatively, through 60 days long term toxicity tests, no matter the result shows the symptom from macroscopic observation, or the histopathology morphological examination from the microcosmic and routine blood test liver function, renal function chemical examination illustrate that all this medicine long term toxicity is little.
4, clinical trial: carry out clinical experiment by units such as Gansu Provincial Hospital of Traditional Chinese Medicine, first, second Affiliated Hospital of Lanzhou medical college, treatment chronic pharyngitis 302 examples, other establishes contrast 152 examples and adopts LIYANLING PIAN.With the symptom that chronic pharyngitis was showed: have sore throat, the improvement situation before and after the bottleneck throat discomfort, dry cough, the sticking less treatment of expectoration is the symptom index of keeping the score, respectively medication 7 days, carried out statistical analysis (referring to table 1) in 14,21,35.
Table 1: the cardinal symptom situation of change of keeping the score before and after the medication
| Symptom | Grouping | After the medication 7 days | After the medication 14 days | After the medication 21 days | After the medication 35 days | ||||
| N | Average decline divided | N | Average decline divided | N | Average decline divided | N | Average decline divided | ||
| Have sore throat | The treatment group | 103 | 0.90 | 117 | 1.44 | 119 | 1.66 | 54 | 1.89 |
| Matched group | 126 | 0.67 | 128 | 1.06 | 130 | 1.49 | 57 | 1.68 | |
| The bottleneck throat discomfort | The treatment group | 98 | 0.76 | 99 | 1.07 | 127 | 1.54 | 68 | 1.84 |
| Matched group | 86 | 0.72 | 103 | 0.83 | 141 | 1.25 | 71 | 1.62 | |
| Dry cough | The treatment group | 69 | 0.42 | 70 | 0.8 | 72 | 1.04 | 34 | 1.26 |
| Matched group | 80 | 0.41 | 95 | 0.75 | 96 | 1.00 | 46 | 1.13 | |
| Expectoration is sticking less | The treatment group | 74 | 0.38 | 76 | 0.75 | 76 | 1.07 | 37 | 1.32 |
| Matched group | 75 | 0.23 | 76 | 0.67 | 74 | 0.91 | 36 | 0.89 | |
Appear the index of keeping the score that situation, throat wall mucosal hyperplasia plumpness, throat wall lymph foilicie hyperplasia and the atrophy at the year end of throat wall are main physical signs before and after the medication with the congested situation of throat wall, throat parietal vessel, respectively medication 7 days, carried out statistical analysis (referring to table 2) in 14,21,35.
Table 2: the change of keeping the score of main physical signs before and after the medication
| Symptom | Grouping | After the medication 7 days | After the medication 14 days | After the medication 21 days | After the medication 35 days | ||||
| N | Average decline divided | N | Average decline divided | N | Average decline divided | N | Average decline divided | ||
| The hyperemia of pharynx rear wall | The treatment group | 90 | 0.67 | 96 | 1.28 | 96 | 1.54 | 40 | 1.73 |
| Matched group | 75 | 0.51 | 79 | 0.92 | 80 | 1.43 | 35 | 1.60 | |
| Pharynx rear wall exposed vessel | The treatment group | 39 | 0.54 | 47 | 0.74 | 47 | 1.02 | 20 | 1.55 |
| Matched group | 45 | 0.27 | 45 | 0.42 | 46 | 0.65 | 20 | 0.95 | |
| Pharynx rear wall mucosal hyperplasia plumpness | The treatment group | 34 | 0.65 | 39 | 1.08 | 27 | 1.26 | 12 | 1.42 |
| Matched group | 40 | 0.40 | 40 | 0.80 | 40 | 1.25 | 12 | 1.42 | |
| Retropharyneal folliculosis | The treatment group | 132 | 0.39 | 134 | 0.72 | 135 | 0.98 | 82 | 1.18 |
| Matched group | 134 | 0.16 | 136 | 0.31 | 136 | 0.51 | 50 | 0.72 | |
| Pharynx rear wall mucosal atrophy | The treatment group | 85 | 0.47 | 93 | 0.90 | 93 | 1.55 | 71 | 1.70 |
| Matched group | 95 | 0.32 | 97 | 0.71 | 97 | 1.10 | 58 | 1.41 | |
The result shows:
1, mixture treatment chronic pharyngitis of the present invention has obvious curative effects, clinical effective rate 94.08, and matched group 75.66%, apparently higher than matched group, P is all less than 0.01.
2, onset of cardinal symptom sign and extinction time, average onset of cardinal symptom sign and hour time are significantly shorter than matched group, and P is less than 0.05, and the cardinal symptom sign branch that on average descends obviously is higher than matched group.
3, pharyngeal pathologic finding: pathologic finding before and after the medication, 30 examples are organized in treatment, matched group 20 examples, branch on average falls after the every index treatment of comprehensive judgement, the treatment group is apparently higher than matched group, and P illustrates that less than 0.01 the gold ginseng wets one's whistle mixture to the effect of having clear improvement of chronic pharyngitis focus.
The specific embodiment
Embodiment 1: the preparation of mixture of the present invention:
Prescription:
60 parts of 25 parts of Radix Platycodoniss of 35 parts of Fructus Forsythiaes of 20 portions of Flos Loniceraes of 25 portions of Radix Rehmanniae of Radix Scrophulariae
275 parts of 0.2 part of Mel of 20 parts of Borneolum Syntheticums of 60 portions of Radix Glycyrrhizaes of 60 parts of Radix Isatidiss of Rhizoma Belamcandae
Technology:
1. with Radix Scrophulariae, Fructus Forsythiae, Radix Platycodonis, Radix Isatidis, Rhizoma Belamcandae, Radix Rehmanniae, Radix Glycyrrhizae with the water boiling and extraction of 15 times of amounts three times, each 1 hour extraction time, merge decoction liquor, filter;
2. be warm macerating three times in 50 ℃ of water with Flos Lonicerae 10 times of amounts, temperature, each 3 hours, merge warm macerating liquid, filter;
3. merge above-mentioned decoction liquor and warm macerating liquid, being evaporated to proportion is 1.06g/ml, filters;
4. in above-mentioned concentrated solution, add sterilized Mel, stir and make its mixing;
5. add Borneolum Syntheticum, stir, mix homogeneously must get the active component of medicine of the present invention.
6. in the medicine activity component of producing, add 0.2 part of antiseptic ethyl hydroxybenzoate, add water and make its concentration to 0.4 ‰, transfer PH to 4.1 with citric acid then, stir evenly, divide pack mixture.
Embodiment 2: the preparation of mixture of the present invention:
Prescription:
20 parts of 35 parts of Radix Platycodoniss of 45 parts of Fructus Forsythiaes of 30 portions of Flos Loniceraes of 40 portions of Radix Rehmanniae of Radix Scrophulariae
500 parts of 0.1 part of Mel of 16.5 parts of Borneolum Syntheticums of 20 portions of Radix Glycyrrhizaes of 20 parts of Radix Isatidiss of Rhizoma Belamcandae
Technology:
1. with Radix Scrophulariae, Fructus Forsythiae, Radix Platycodonis, Radix Isatidis, Rhizoma Belamcandae, Radix Rehmanniae, Radix Glycyrrhizae with the water boiling and extraction of 10 times of amounts three times, each 2 hours extraction times, merge decoction liquor, filter;
2. be warm macerating three times in 60 ℃ of water with Flos Lonicerae 10 times of amounts, temperature, each 2 hours, merge warm macerating liquid, filter;
3. merge above-mentioned decoction liquor and warm macerating liquid, being evaporated to proportion is 1.07g/ml, filters;
4. in above-mentioned concentrated solution, add sterilized Mel, stir and make its mixing;
5. add Borneolum Syntheticum, stir, mix homogeneously must get the active component of medicine of the present invention.
6. in the medicine activity component of producing, add 0.4 part of antiseptic ethyl hydroxybenzoate, add water and make its concentration to 0.6 ‰, transfer PH to 4.5 with citric acid then, stir evenly, divide pack mixture.
Embodiment 3: the preparation of mixture of the present invention:
Prescription:
40 parts of 45 parts of Radix Platycodoniss of 55 parts of Fructus Forsythiaes of 40 portions of Flos Loniceraes of 55 portions of Radix Rehmanniae of Radix Scrophulariae
300 parts of 0.25 part of Mel of 25 parts of Borneolum Syntheticums of 30 portions of Radix Glycyrrhizaes of 30 parts of Radix Isatidiss of Rhizoma Belamcandae
Technology:
1. with Radix Scrophulariae, Fructus Forsythiae, Radix Platycodonis, Radix Isatidis, Rhizoma Belamcandae, Radix Rehmanniae, Radix Glycyrrhizae with the water boiling and extraction of 5 times of amounts three times, each 1 hour extraction time, merge decoction liquor, filter;
2. be warm macerating three times in 70 ℃ of water with Flos Lonicerae 15 times of amounts, temperature, each 1 hour, merge warm macerating liquid, filter;
3. merge above-mentioned decoction liquor and warm macerating liquid, being evaporated to proportion is 1.08g/ml, filters;
4. in above-mentioned concentrated solution, add sterilized Mel, stir and make its mixing;
5. add Borneolum Syntheticum, stir, mix homogeneously must get the active component of medicine of the present invention.
6. in the medicine activity component of producing, add 0.6 part of antiseptic ethyl hydroxybenzoate, add water and make its concentration to 0.8 ‰, transfer PH to 5.0 with citric acid then, stir evenly, divide pack mixture.
The preparation of embodiment 4, tablet of the present invention:
Prescription:
50 parts of 55 parts of Radix Platycodoniss of 55 parts of Fructus Forsythiaes of 50 portions of Flos Loniceraes of 65 portions of Radix Rehmanniae of Radix Scrophulariae
400 parts of 0.3 part of Mel of 30 parts of Borneolum Syntheticums of 50 portions of Radix Glycyrrhizaes of 50 parts of Radix Isatidiss of Rhizoma Belamcandae
Technology:
1. with Radix Scrophulariae, Fructus Forsythiae, Radix Platycodonis, Radix Isatidis, Rhizoma Belamcandae, Radix Rehmanniae, Radix Glycyrrhizae with the water boiling and extraction of 12 times of amounts three times, each 1.5 hours extraction times, merge decoction liquor, filter;
2. be warm macerating three times in 80 ℃ of water with Flos Lonicerae 12 times of amounts, temperature, each 0.5 hour, merge warm macerating liquid, filter;
3. merge above-mentioned decoction liquor and warm macerating liquid, being evaporated to proportion is 1.06g/ml, filters;
4. in above-mentioned concentrated solution, add sterilized Mel, stir and make its mixing;
5. with behind the concentrated solution vacuum drying, be ground into fine powder, make granule with 40% ethanol; Spray into the alcoholic solution (concentration is 0.006g/ml) of Borneolum Syntheticum after the drying, mixing, tabletting is shaped.
Embodiment 5:
The preparation of tablet of the present invention:
Prescription:
20 parts of 25 parts of Radix Platycodoniss of 65 parts of Fructus Forsythiaes of 50 portions of Flos Loniceraes of 75 portions of Radix Rehmanniae of Radix Scrophulariae
600 parts of 0.2 part of Mel of 40 parts of Borneolum Syntheticums of 60 portions of Radix Glycyrrhizaes of 20 parts of Radix Isatidiss of Rhizoma Belamcandae
Technology:
1. with Radix Scrophulariae, Fructus Forsythiae, Radix Platycodonis, Radix Isatidis, Rhizoma Belamcandae, Radix Rehmanniae, Radix Glycyrrhizae with the water boiling and extraction of 8 times of amounts three times, each 2.5 hours extraction times, merge decoction liquor, filter;
2. be warm macerating three times in 90 ℃ of water with Flos Lonicerae 18 times of amounts, temperature, each 1.5 hours, merge warm macerating liquid, filter;
3. merge above-mentioned decoction liquor and warm macerating liquid, being evaporated to proportion is 1.07g/ml, filters;
4. in above-mentioned concentrated solution, add sterilized Mel, stir and make its mixing;
5. with after above-mentioned concentrated solution vacuum drying or the spray drying, be ground into fine powder, make granule with 60% ethanol; Spray into the alcoholic solution (concentration is 0.01g/ml) of Borneolum Syntheticum after the drying, mixing, tabletting is shaped.
Embodiment 6:
The preparation prescription of tablet of the present invention:
40 parts of 50 parts of Radix Platycodoniss of 50 parts of Fructus Forsythiaes of 40 portions of Flos Loniceraes of 50 portions of Radix Rehmanniae of Radix Scrophulariae
825 parts of 0.15 part of Mel of 49.5 parts of Borneolum Syntheticums of 40 portions of Radix Glycyrrhizaes of 60 parts of Radix Isatidiss of Rhizoma Belamcandae
Technology:
1. with Radix Scrophulariae, Fructus Forsythiae, Radix Platycodonis, Radix Isatidis, Rhizoma Belamcandae, Radix Rehmanniae, Radix Glycyrrhizae with the water boiling and extraction of 10 times of amounts three times, each 1 hour extraction time, merge decoction liquor, filter;
2. be warm macerating three times in 70 ℃ of water with Flos Lonicerae 15 times of amounts, temperature, each 1 hour, merge warm macerating liquid, filter;
3. merge above-mentioned decoction liquor and warm macerating liquid, being evaporated to proportion is 1.08g/ml, filters;
4. in above-mentioned concentrated solution, add sterilized Mel, stir and make its mixing;
5. with after above-mentioned concentrated solution vacuum drying or the spray drying, be ground into fine powder, make granule with 85% ethanol; Spray into the alcoholic solution (concentration is 0.2g/ml) of Borneolum Syntheticum after the drying, mixing, tabletting is shaped.
Claims (8)
1, a kind of Chinese medicine composition for the treatment of chronic pharyngitis and phlegm-heat is to be prepared from by following materials of weight proportions:
35～75 parts of 20～60 portions of Flos Loniceraes of 25～75 portions of Radix Rehmanniae of Radix Scrophulariae
20～60 parts of 20～60 parts of Radix Isatidiss of 25～75 parts of Radix Platycodoniss of Fructus Forsythiae
16.5～49.5 parts in 0.1～0.3 portion of Radix Glycyrrhizae of 20～60 parts of Borneolum Syntheticums of Rhizoma Belamcandae
275～825 parts of Mel.
2, a kind of Chinese medicine composition for the treatment of chronic pharyngitis and phlegm-heat as claimed in claim 1 is to be formed by following prepared:
1. with Radix Scrophulariae, Fructus Forsythiae, Radix Platycodonis, Radix Isatidis, Rhizoma Belamcandae, Radix Rehmanniae, Radix Glycyrrhizae with the water boiling and extraction of 5～15 times of amounts three times, each 1～3 hour extraction time, merge decoction liquor, filter;
2. be warm macerating three times in 50～90 ℃ of water with Flos Lonicerae 10～20 times of amounts, temperature, each 0.5～3 hour, merge warm macerating liquid, filter;
3. merge above-mentioned decoction liquor and warm macerating liquid, being evaporated to proportion is 1.06～1.08g/ml, filters;
4. in above-mentioned concentrated solution, add sterilized Mel, stir and make its mixing;
5. add Borneolum Syntheticum, stir, mix homogeneously must get the active component of medicine of the present invention.
3, the Chinese medicine composition of treatment chronic pharyngitis as claimed in claim 2 and phlegm-heat is characterized in that: the medicine activity component of producing is made mixture.
4, the mixture of the Chinese medicine composition of treatment chronic pharyngitis as claimed in claim 3 and phlegm-heat, it is characterized in that: its preparation technology is: add 0.2～0.6 part of antiseptic in the medicine activity component of producing, and add water and make its concentration to 0.4 ‰-0.8 ‰, transfer PH to 4.1～5.0 with citric acid then, stir evenly, divide pack mixture.
5, the mixture of the Chinese medicine composition of treatment chronic pharyngitis as claimed in claim 4 and phlegm-heat is characterized in that: described antiseptic is an ethyl hydroxybenzoate.
6, the Chinese medicine composition of treatment chronic pharyngitis as claimed in claim 2 and phlegm-heat is characterized in that: medicine activity component and tablet auxiliary materials and mixing commonly used with producing are pressed into tablet.
7, the tablet of the Chinese medicine composition of treatment chronic pharyngitis as claimed in claim 6 and phlegm-heat, it is characterized in that: its preparation technology is: above-mentioned adding has been sterilized behind the concentrated solution vacuum drying or spray drying behind the Mel, be ground into fine powder, make granule with 40%～85% ethanol; Spray into the alcoholic solution of Borneolum Syntheticum after the drying, mixing, tabletting is shaped.
8, the tablet of the Chinese medicine composition of treatment chronic pharyngitis as claimed in claim 7 and phlegm-heat is characterized in that: the alcoholic solution concentration of described Borneolum Syntheticum is 0.006～0.2g/ml.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510096229 CN1772098A (en) | 2005-10-18 | 2005-10-18 | Chinese medicine composition for treating chronic pharyngitis and phlegm-heat and its prepn process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510096229 CN1772098A (en) | 2005-10-18 | 2005-10-18 | Chinese medicine composition for treating chronic pharyngitis and phlegm-heat and its prepn process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1772098A true CN1772098A (en) | 2006-05-17 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101062202B (en) * | 2007-06-07 | 2010-05-19 | 王立敏 | Agent for preventing and treating common cold |
| CN102406827A (en) * | 2010-11-25 | 2012-04-11 | 中国人民解放军第四军医大学 | Pharyngitis chewable tablets and molding process thereof |
| CN105999000A (en) * | 2016-06-14 | 2016-10-12 | 罗朝邦 | Traditional Chinese medicine for treating chronic pharyngitis |
-
2005
- 2005-10-18 CN CN 200510096229 patent/CN1772098A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101062202B (en) * | 2007-06-07 | 2010-05-19 | 王立敏 | Agent for preventing and treating common cold |
| CN102406827A (en) * | 2010-11-25 | 2012-04-11 | 中国人民解放军第四军医大学 | Pharyngitis chewable tablets and molding process thereof |
| CN105999000A (en) * | 2016-06-14 | 2016-10-12 | 罗朝邦 | Traditional Chinese medicine for treating chronic pharyngitis |
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