CN101053631A - Preparation method for effective drug capsule for gastric disease - Google Patents
Preparation method for effective drug capsule for gastric disease Download PDFInfo
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Abstract
Disclosed is a method for preparing 'Wei Kang Ling' capsule which consists of white peony root 317.5g, hyacinth bletilla 238.1g, notoginseng 9.9g, licorice 317.2g, poria 238.1g, corydalis tuber 158.7g and cuttlebone 31.7g, belladonna 2.1g and medicinal adjuvant. The invention improves the powder property of capsule content and reduces the difference of loading capacity by modifying the process.
Description
[technical field]
The invention belongs to technical field of medicine, be specifically related to a kind of preparation method of stomach-recovering capsule.
[background technology]
Stomach-recovering capsule is to act as the basis with peony and licorice decoction antiulcer in the famous TCM work treatise on Febrile Diseases, genuine Chinese crude drugs such as compatibility Radix Notoginseng, Rhizoma Corydalis, Endoconcha Sepiae simultaneously, Semen daturae extractum in addition, through science extract, the refining gastropathy good medicine that forms.WEIKANGLING has spasmolytic, analgesia, hemostasis, antacid, comprehensive repair gastric mucosa, eliminates the effect of ulcer and surrounding tissue inflammation.This product is a hard capsule, and content is faint yellow to brown powder; Sweet in the mouth.
Stomach-recovering capsule easing the affected liver stomach function regulating, the dissipating blood stasis hemostasis, relieving spasm to stop pain is removed the rotten and let fresh grow.Be used for incoordination between the liver and stomach, stomach alkane pain, company and two sides of body, belch, pantothenic acid due to the obstruction of collaterals by blood stasis; Acute and chronic gastritis, stomach, duodenal ulcer, gastrorrhagia is seen above-mentioned patient.
The prescription and the preparation method of 2005 editions (one one) 518 pages of disclosed stomach-recovering capsules of Chinese Pharmacopoeia are:
Prescription: the Pseudobulbus Bletillae (Rhizoma Bletillae) 238.1 gram Radix Paeoniae Albas 317.5 grams
Radix Notoginseng 9.9 gram Radix Glycyrrhizaes 317.2 grams
Poria 238.1 gram Rhizoma Corydalis 158.7 grams
Endoconcha Sepiae 31.7 gram Semen daturae extractums 2.1 grams
Method for making: above eight flavors, Pseudobulbus Bletillae (Rhizoma Bletillae) and Radix Notoginseng are pulverized and are granularity 90-125 purpose fine powder, Endoconcha Sepiae are pulverized be granularity 100-200 purpose fine powder; Radix Glycyrrhizae decocts with water four times, first and second time each 3 hours, and third and fourth time each 2 hours, decocting liquid filters, and filtrate merges, and leaves standstill 24 hours, gets supernatant, and is standby; The Radix Paeoniae Alba, Rhizoma Corydalis, Poria decoct with water secondary, and 3 hours for the first time, 2 hours for the second time, decocting liquid filters, and filtrate merges, and leaves standstill 24 hours, get supernatant, merge, be concentrated into an amount of with above-mentioned supernatant, add above-mentioned fine powder and Semen daturae extractum, stir evenly, drying, be ground into fine powder, add an amount of adjuvant, incapsulate and make 1000, promptly.
Domesticly have a sale that 98 tame enterprises are engaged in stomach-recovering capsule, wherein the output of sunflower Pharmaceutical and Renhe Pharmaceutical is bigger, the technology comparative maturity.But in 518 pages of concrete preparation process of Chinese Pharmacopoeia 2005 editions (an one), do not provide the grinding particle size of concrete Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng, Endoconcha Sepiae, and full medical material is used as medicine in the Chinese medicine, its grinding particle size is a key parameter, concerning the homogeneous degree and the capsular content uniformity of various compositions in the compound medicine.Seem simple, actually the big problem that can in time obtain medical treatment concerning the patient who is in the gastropathy torment.
[summary of the invention]
Another object of the present invention is to provide the preparation method of stomach-recovering capsule.
Specifically, in the preparation method of this method Pseudobulbus Bletillae (Rhizoma Bletillae) and Radix Notoginseng pulverizing are granularity 90-125 purpose fine powder, it is granularity 100-200 purpose fine powder that Endoconcha Sepiae is pulverized.
In the preferred manufacturing procedure Pseudobulbus Bletillae (Rhizoma Bletillae) and Radix Notoginseng pulverizing are granularity 100-125 purpose fine powder, it is granularity 150-200 purpose fine powder that Endoconcha Sepiae is pulverized.
In the preferred preparation method Pseudobulbus Bletillae (Rhizoma Bletillae) and Radix Notoginseng pulverizing are granularity 100 purpose fine powders, it is granularity 150 purpose fine powders that Endoconcha Sepiae is pulverized.
The tradition traditional Chinese medical science is thought: " deposit one fen gastric qi, deposit one fen life ".Thereby the treatment of gastropathy is most important for the adjusting of the whole body function of human body.The prescription of WEIKANGLING is: the Radix Paeoniae Alba 317.5 grams, Pseudobulbus Bletillae (Rhizoma Bletillae), 238.1 grams, Radix Notoginseng 9.9 grams, Radix Glycyrrhizae 317.2 grams, Poria 238.1 grams, Rhizoma Corydalis 158.7 grams, Endoconcha Sepiae 31.7 grams, Semen daturae extractum 2.1 grams; Such as these a few flavor Chinese medicines of the Radix Paeoniae Alba, Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Glycyrrhizae, Poria and Rhizoma Corydalis nearly more than 150 grams, its dosage all is accurate to one-bit digital behind the arithmetic point, illustrates what this prescription was strict to the assurance of dosage; And the medicine that Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng and the full medical material of Endoconcha Sepiae three flavors are used as medicine more wants accurate distribution in capsule.If can not accomplish the homogeneity of various compositions in the stomach-recovering capsule preparation process, the situation of " a small discrepancy leads to a great error " then can take place in clinical practice.Though, reduce content uniformity so improve the powder characteristics of capsule 's content; Say it only is on the microcosmic for the homogeneity that guarantees compound medicine more and the stability of content uniformity; Can postpone and eliminate with the up to ten million slight illness of taking the stomach-recovering capsule patient in the whole nation highly beneficial on the macroscopic view.
The present invention has significantly improved the powder characteristics of capsule 's content by the improvement to technology, has reduced content uniformity.
[specific embodiment]
Following embodiment further describes the present invention, but described embodiment only is used to illustrate the present invention rather than restriction the present invention.
Embodiment 1
The prescription Pseudobulbus Bletillae (Rhizoma Bletillae) 238.1 gram Radix Paeoniae Albas 317.5 grams
Radix Notoginseng 9.9 gram Radix Glycyrrhizaes 317.2 grams
Poria 238.1 gram Rhizoma Corydalis 158.7 grams
Endoconcha Sepiae 31.7 gram Semen daturae extractums 2.1 grams
Method for making: above eight flavors, Pseudobulbus Bletillae (Rhizoma Bletillae) and Radix Notoginseng are pulverized and are granularity 90 purpose fine powders, Endoconcha Sepiae are pulverized be granularity 100 purpose fine powders; Radix Glycyrrhizae decocts with water four times, first and second time each 3 hours, and third and fourth time each 2 hours, decocting liquid filters, and filtrate merges, and leaves standstill 24 hours, gets supernatant, and is standby; The Radix Paeoniae Alba, Rhizoma Corydalis, Poria decoct with water secondary, and 3 hours for the first time, 2 hours for the second time, decocting liquid filters, and filtrate merges, and leaves standstill 24 hours, get supernatant, merge, be concentrated into an amount of with above-mentioned supernatant, add above-mentioned fine powder and Semen daturae extractum, stir evenly, drying, be ground into fine powder, add an amount of adjuvant, incapsulate and make 1000, promptly.
Embodiment 2
The prescription Pseudobulbus Bletillae (Rhizoma Bletillae) 238.1 gram Radix Paeoniae Albas 317.5 grams
Radix Notoginseng 9.9 gram Radix Glycyrrhizaes 317.2 grams
Poria 238.1 gram Rhizoma Corydalis 158.7 grams
Endoconcha Sepiae 31.7 gram Semen daturae extractums 2.1 grams
Method for making: above eight flavors, Pseudobulbus Bletillae (Rhizoma Bletillae) and Radix Notoginseng are pulverized and are granularity 90 purpose fine powders, Endoconcha Sepiae are pulverized be granularity 150 purpose fine powders; Radix Glycyrrhizae decocts with water four times, first and second time each 3 hours, and third and fourth time each 2 hours, decocting liquid filters, and filtrate merges, and leaves standstill 24 hours, gets supernatant, and is standby; The Radix Paeoniae Alba, Rhizoma Corydalis, Poria decoct with water secondary, and 3 hours for the first time, 2 hours for the second time, decocting liquid filters, and filtrate merges, and leaves standstill 24 hours, get supernatant, merge, be concentrated into an amount of with above-mentioned supernatant, add above-mentioned fine powder and Semen daturae extractum, stir evenly, drying, be ground into fine powder, add an amount of adjuvant, incapsulate and make 1000, promptly.
Embodiment 3
The prescription Pseudobulbus Bletillae (Rhizoma Bletillae) 238.1 gram Radix Paeoniae Albas 317.5 grams
Radix Notoginseng 9.9 gram Radix Glycyrrhizaes 317.2 grams
Poria 238.1 gram Rhizoma Corydalis 158.7 grams
Endoconcha Sepiae 31.7 gram Semen daturae extractums 2.1 grams
Method for making: above eight flavors, Pseudobulbus Bletillae (Rhizoma Bletillae) and Radix Notoginseng are pulverized and are granularity 100 purpose fine powders, Endoconcha Sepiae are pulverized be granularity 150 purpose fine powders; Radix Glycyrrhizae decocts with water four times, first and second time each 3 hours, and third and fourth time each 2 hours, decocting liquid filters, and filtrate merges, and leaves standstill 24 hours, gets supernatant, and is standby; The Radix Paeoniae Alba, Rhizoma Corydalis, Poria decoct with water secondary, and 3 hours for the first time, 2 hours for the second time, decocting liquid filters, and filtrate merges, and leaves standstill 24 hours, get supernatant, merge, be concentrated into an amount of with above-mentioned supernatant, add above-mentioned fine powder and Semen daturae extractum, stir evenly, drying, be ground into fine powder, add an amount of adjuvant, incapsulate and make 1000, promptly.
Embodiment 4
The prescription Pseudobulbus Bletillae (Rhizoma Bletillae) 238.1 gram Radix Paeoniae Albas 317.5 grams
Radix Notoginseng 9.9 gram Radix Glycyrrhizaes 317.2 grams
Poria 238.1 gram Rhizoma Corydalis 158.7 grams
Endoconcha Sepiae 31.7 gram Semen daturae extractums 2.1 grams
Method for making: above eight flavors, Pseudobulbus Bletillae (Rhizoma Bletillae) and Radix Notoginseng are pulverized and are granularity 125 purpose fine powders, Endoconcha Sepiae are pulverized be granularity 200 purpose fine powders; Radix Glycyrrhizae decocts with water four times, first and second time each 3 hours, and third and fourth time each 2 hours, decocting liquid filters, and filtrate merges, and leaves standstill 24 hours, gets supernatant, and is standby; The Radix Paeoniae Alba, Rhizoma Corydalis, Poria decoct with water secondary, and 3 hours for the first time, 2 hours for the second time, decocting liquid filters, and filtrate merges, and leaves standstill 24 hours, get supernatant, merge, be concentrated into an amount of with above-mentioned supernatant, add above-mentioned fine powder and Semen daturae extractum, stir evenly, drying, be ground into fine powder, add an amount of adjuvant, incapsulate and make 1000, promptly.
Embodiment 5
The prescription Pseudobulbus Bletillae (Rhizoma Bletillae) 238.1 gram Radix Paeoniae Albas 317.5 grams
Radix Notoginseng 9.9 gram Radix Glycyrrhizaes 317.2 grams
Poria 238.1 gram Rhizoma Corydalis 158.7 grams
Endoconcha Sepiae 31.7 gram Semen daturae extractums 2.1 grams
Method for making: above eight flavors, Pseudobulbus Bletillae (Rhizoma Bletillae) and Radix Notoginseng are pulverized and are granularity 125 purpose fine powders, Endoconcha Sepiae are pulverized be granularity 150 purpose fine powders; Radix Glycyrrhizae decocts with water four times, first and second time each 3 hours, and third and fourth time each 2 hours, decocting liquid filters, and filtrate merges, and leaves standstill 24 hours, gets supernatant, and is standby; The Radix Paeoniae Alba, Rhizoma Corydalis, Poria decoct with water secondary, and 3 hours for the first time, 2 hours for the second time, decocting liquid filters, and filtrate merges, and leaves standstill 24 hours, get supernatant, merge, be concentrated into an amount of with above-mentioned supernatant, add above-mentioned fine powder and Semen daturae extractum, stir evenly, drying, be ground into fine powder, add an amount of adjuvant, incapsulate and make 1000, promptly.
Embodiment 6
The prescription Pseudobulbus Bletillae (Rhizoma Bletillae) 238.1 gram Radix Paeoniae Albas 317.5 grams
Radix Notoginseng 9.9 gram Radix Glycyrrhizaes 317.2 grams
Poria 238.1 gram Rhizoma Corydalis 158.7 grams
Endoconcha Sepiae 31.7 gram Semen daturae extractums 2.1 grams
Method for making: above eight flavors, Pseudobulbus Bletillae (Rhizoma Bletillae) and Radix Notoginseng are pulverized and are granularity 125 purpose fine powders, Endoconcha Sepiae are pulverized be granularity 200 purpose fine powders; Radix Glycyrrhizae decocts with water four times, first and second time each 3 hours, and third and fourth time each 2 hours, decocting liquid filters, and filtrate merges, and leaves standstill 24 hours, gets supernatant, and is standby; The Radix Paeoniae Alba, Rhizoma Corydalis, Poria decoct with water secondary, and 3 hours for the first time, 2 hours for the second time, decocting liquid filters, and filtrate merges, and leaves standstill 24 hours, get supernatant, merge, be concentrated into an amount of with above-mentioned supernatant, add above-mentioned fine powder and Semen daturae extractum, stir evenly, drying, be ground into fine powder, add an amount of adjuvant, incapsulate and make 1000, promptly.
Comparative Examples 1
The prescription Pseudobulbus Bletillae (Rhizoma Bletillae) 238.1 gram Radix Paeoniae Albas 317.5 grams
Radix Notoginseng 9.9 gram Radix Glycyrrhizaes 317.2 grams
Poria 238.1 gram Rhizoma Corydalis 158.7 grams
Endoconcha Sepiae 31.7 gram Semen daturae extractums 2.1 grams
Method for making: above eight flavors, Pseudobulbus Bletillae (Rhizoma Bletillae) and Radix Notoginseng are pulverized and are granularity 60 purpose fine powders, Endoconcha Sepiae are pulverized be granularity 100 purpose fine powders; Radix Glycyrrhizae decocts with water four times, first and second time each 3 hours, and third and fourth time each 2 hours, decocting liquid filters, and filtrate merges, and leaves standstill 24 hours, gets supernatant, and is standby; The Radix Paeoniae Alba, Rhizoma Corydalis, Poria decoct with water secondary, and 3 hours for the first time, 2 hours for the second time, decocting liquid filters, and filtrate merges, and leaves standstill 24 hours, get supernatant, merge, be concentrated into an amount of with above-mentioned supernatant, add above-mentioned fine powder and Semen daturae extractum, stir evenly, drying, be ground into fine powder, add an amount of adjuvant, incapsulate and make 1000, promptly.
Comparative Examples 2
The prescription Pseudobulbus Bletillae (Rhizoma Bletillae) 238.1 gram Radix Paeoniae Albas 317.5 grams
Radix Notoginseng 9.9 gram Radix Glycyrrhizaes 317.2 grams
Poria 238.1 gram Rhizoma Corydalis 158.7 grams
Endoconcha Sepiae 31.7 gram Semen daturae extractums 2.1 grams
Method for making: above eight flavors, Pseudobulbus Bletillae (Rhizoma Bletillae) and Radix Notoginseng are pulverized and are granularity 60 purpose fine powders, Endoconcha Sepiae are pulverized be granularity 150 purpose fine powders; Radix Glycyrrhizae decocts with water four times, first and second time each 3 hours, and third and fourth time each 2 hours, decocting liquid filters, and filtrate merges, and leaves standstill 24 hours, gets supernatant, and is standby; The Radix Paeoniae Alba, Rhizoma Corydalis, Poria decoct with water secondary, and 3 hours for the first time, 2 hours for the second time, decocting liquid filters, and filtrate merges, and leaves standstill 24 hours, get supernatant, merge, be concentrated into an amount of with above-mentioned supernatant, add above-mentioned fine powder and Semen daturae extractum, stir evenly, drying, be ground into fine powder, add an amount of adjuvant, incapsulate and make 1000, promptly.
Comparative Examples 3
The prescription Pseudobulbus Bletillae (Rhizoma Bletillae) 238.1 gram Radix Paeoniae Albas 317.5 grams
Radix Notoginseng 9.9 gram Radix Glycyrrhizaes 317.2 grams
Poria 238.1 gram Rhizoma Corydalis 158.7 grams
Endoconcha Sepiae 31.7 gram Semen daturae extractums 2.1 grams
Method for making: above eight flavors, Pseudobulbus Bletillae (Rhizoma Bletillae) and Radix Notoginseng are pulverized and are granularity 100 purpose fine powders, Endoconcha Sepiae are pulverized be granularity 300 purpose fine powders; Radix Glycyrrhizae decocts with water four times, first and second time each 3 hours, and third and fourth time each 2 hours, decocting liquid filters, and filtrate merges, and leaves standstill 24 hours, gets supernatant, and is standby; The Radix Paeoniae Alba, Rhizoma Corydalis, Poria decoct with water secondary, and 3 hours for the first time, 2 hours for the second time, decocting liquid filters, and filtrate merges, and leaves standstill 24 hours, get supernatant, merge, be concentrated into an amount of with above-mentioned supernatant, add above-mentioned fine powder and Semen daturae extractum, stir evenly, drying, be ground into fine powder, add an amount of adjuvant, incapsulate and make 1000, promptly.
Comparative Examples 4
The prescription Pseudobulbus Bletillae (Rhizoma Bletillae) 238.1 gram Radix Paeoniae Albas 317.5 grams
Radix Notoginseng 9.9 gram Radix Glycyrrhizaes 317.2 grams
Poria 238.1 gram Rhizoma Corydalis 158.7 grams
Endoconcha Sepiae 31.7 gram Semen daturae extractums 2.1 grams
Method for making: above eight flavors, Pseudobulbus Bletillae (Rhizoma Bletillae) and Radix Notoginseng are pulverized and are granularity 60 purpose fine powders, Endoconcha Sepiae are pulverized be granularity 300 purpose fine powders; Radix Glycyrrhizae decocts with water four times, first and second time each 3 hours, and third and fourth time each 2 hours, decocting liquid filters, and filtrate merges, and leaves standstill 24 hours, gets supernatant, and is standby; The Radix Paeoniae Alba, Rhizoma Corydalis, Poria decoct with water secondary, and 3 hours for the first time, 2 hours for the second time, decocting liquid filters, and filtrate merges, and leaves standstill 24 hours, get supernatant, merge, be concentrated into an amount of with above-mentioned supernatant, add above-mentioned fine powder and Semen daturae extractum, stir evenly, drying, be ground into fine powder, add an amount of adjuvant, incapsulate and make 1000, promptly.
Comparative Examples 5
The prescription Pseudobulbus Bletillae (Rhizoma Bletillae) 238.1 gram Radix Paeoniae Albas 317.5 grams
Radix Notoginseng 9.9 gram Radix Glycyrrhizaes 317.2 grams
Poria 238.1 gram Rhizoma Corydalis 158.7 grams
Endoconcha Sepiae 31.7 gram Semen daturae extractums 2.1 grams
Method for making: above eight flavors, Pseudobulbus Bletillae (Rhizoma Bletillae) and Radix Notoginseng are pulverized and are granularity 60 purpose fine powders, Endoconcha Sepiae are pulverized be granularity 150 purpose fine powders; Radix Glycyrrhizae decocts with water four times, first and second time each 3 hours, and third and fourth time each 2 hours, decocting liquid filters, and filtrate merges, and leaves standstill 24 hours, gets supernatant, and is standby; The Radix Paeoniae Alba, Rhizoma Corydalis, Poria decoct with water secondary, and 3 hours for the first time, 2 hours for the second time, decocting liquid filters, and filtrate merges, and leaves standstill 24 hours, get supernatant, merge, be concentrated into an amount of with above-mentioned supernatant, add above-mentioned fine powder and Semen daturae extractum, stir evenly, drying, be ground into fine powder, add an amount of adjuvant, incapsulate and make 1000, promptly.
Comparative Examples 6
The prescription Pseudobulbus Bletillae (Rhizoma Bletillae) 238.1 gram Radix Paeoniae Albas 317.5 grams
Radix Notoginseng 9.9 gram Radix Glycyrrhizaes 317.2 grams
Poria 238.1 gram Rhizoma Corydalis 158.7 grams
Endoconcha Sepiae 31.7 gram Semen daturae extractums 2.1 grams
Method for making: above eight flavors, Pseudobulbus Bletillae (Rhizoma Bletillae) and Radix Notoginseng are pulverized and are granularity 60 purpose fine powders, Endoconcha Sepiae are pulverized be granularity 200 purpose fine powders; Radix Glycyrrhizae decocts with water four times, first and second time each 3 hours, and third and fourth time each 2 hours, decocting liquid filters, and filtrate merges, and leaves standstill 24 hours, gets supernatant, and is standby; The Radix Paeoniae Alba, Rhizoma Corydalis, Poria decoct with water secondary, and 3 hours for the first time, 2 hours for the second time, decocting liquid filters, and filtrate merges, and leaves standstill 24 hours, get supernatant, merge, be concentrated into an amount of with above-mentioned supernatant, add above-mentioned fine powder and Semen daturae extractum, stir evenly, drying, be ground into fine powder, add an amount of adjuvant, incapsulate and make 1000, promptly.
The optimization experiment of Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng and Endoconcha Sepiae grinding particle size among experimental example-the present invention
Be particle is subjected to frictional force between gravity and particle when sliding on the free inclined-plane of powder body accumulation horizon effect angle of repose (angle of repose), remains static when these power reach balance.Be the free inclined-plane and the formed maximum angular of horizontal plane of powder body accumulation horizon this moment angle of repose.Be the easiest method of check powder fluidity quality angle of repose.Angle of repose is more little, illustrate that frictional force is more little, flowability is good more, good fluidity when it is generally acknowledged θ angle of repose≤30 °, can substantially satisfy in production process mobile demand during 30 °≤θ≤40 ° angle of repose, when θ＞40 ° will be unfavorable for the fill of capsule particle, this can cause the uneven phenomenon of fill.
The present invention adopts fixed funnel method (248 pages-249 pages of Xi Nianzhu chief editor " pharmaceutics " third editions) to measure the angle of repose of the preceding granule (intermediate) of fill of embodiment and Comparative Examples; (Xi Nianzhu chief editor " pharmaceutics " third edition page or leaf, 326 pages) described method, data such as table 1 are adopted in embodiment and the test of Comparative Examples content uniformity.
Particulate angle of repose of capsule 's content and capsular content uniformity data among table 1 the present invention
| Embodiment | Angle of repose | Embodiment | Content uniformity |
| Embodiment 1 | 28° | Embodiment 1 | ±3.3％ |
| Embodiment 2 | 27° | Embodiment 2 | ±3.5％ |
| Embodiment 3 | 24° | Embodiment 3 | ±2.5％ |
| Embodiment 4 | 28° | Embodiment 4 | ±4.1％ |
| Embodiment 5 | 29° | Embodiment 5 | ±3.5％ |
| Embodiment 6 | 28° | Embodiment 6 | ±3.7％ |
| Comparative Examples | Angle of repose | Comparative Examples | Content uniformity |
| Comparative Examples 1 | 30° | Comparative Examples 1 | ±5.3％ |
| Comparative Examples 2 | 38° | Comparative Examples 2 | ±7.1％ |
| Comparative Examples 3 | 32° | Comparative Examples 3 | ±5.5％ |
| Comparative Examples 4 | 33° | Comparative Examples 4 | ±9.0％ |
| Comparative Examples 5 | 31° | Comparative Examples 5 | ±5.6％ |
| Comparative Examples 6 | 35° | Comparative Examples 6 | ±7.4％ |
As above show the test shows of illustrated embodiment and Comparative Examples, when Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng grinding particle size when 90-125 order and Endoconcha Sepiae grinding particle size are the 100-200 order, be reduced to its angle of repose below 30 °, this helps the stable of capsule loading amount, also this point can be described from the difference of actual fill.And when Pseudobulbus Bletillae (Rhizoma Bletillae), when the Radix Notoginseng grinding particle size is lower than 90 orders and Endoconcha Sepiae grinding particle size when being the above granularity of 200 orders, increase particulate angle of repose in the capsule, content uniformity big this all is unfavorable for the production of capsule, and when Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng grinding particle size be that 100 orders and Endoconcha Sepiae grinding particle size are when being 150 orders, be 24 ° its angle of repose, and the capsule loading amount is the most stable.
Claims (3)
1. the preparation method of a stomach-recovering capsule is characterized in that Pseudobulbus Bletillae (Rhizoma Bletillae) and Radix Notoginseng pulverizing are granularity 90-125 purpose fine powder, Endoconcha Sepiae is pulverized be granularity 100-200 purpose fine powder.
2. according to the described preparation method of claim 1, it is characterized in that Pseudobulbus Bletillae (Rhizoma Bletillae) and Radix Notoginseng pulverizing are granularity 100-125 purpose fine powder that it is granularity 150-200 purpose fine powder that Endoconcha Sepiae is pulverized.
3. according to the described preparation method of claim 2, it is characterized in that Pseudobulbus Bletillae (Rhizoma Bletillae) and Radix Notoginseng pulverizing are granularity 100 purpose fine powders that it is granularity 150 purpose fine powders that Endoconcha Sepiae is pulverized.
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| CNA2007101106111A CN101053631A (en) | 2007-06-07 | 2007-06-07 | Preparation method for effective drug capsule for gastric disease |
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| CNA2007101106111A CN101053631A (en) | 2007-06-07 | 2007-06-07 | Preparation method for effective drug capsule for gastric disease |
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| CN2011103173901A Division CN102349973B (en) | 2007-06-07 | 2007-06-07 | Preparation method of traditional Chinese medicinal capsule |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101439149B (en) * | 2008-12-19 | 2011-04-20 | 黄远吉 | Chinese medicinal composition for treating gastric ulcer, gastrorrhagia and gastric perforation |
| CN103705734A (en) * | 2013-11-28 | 2014-04-09 | 安徽海神寿春药业有限公司 | Traditional Chinese medicine for treating acute or chronic gastritis |
| CN103751688A (en) * | 2013-12-30 | 2014-04-30 | 臧萍 | Chinese herbal medicine for treating stomach diseases and preparation method of Chinese herbal medicine |
| CN103920047A (en) * | 2014-04-27 | 2014-07-16 | 王玉娟 | Traditional Chinese medicine preparation for treating gastrorrhagia and preparation method thereof |
| CN104116978A (en) * | 2014-06-13 | 2014-10-29 | 江美珍 | Traditional Chinese medicine for treating stomach duct pain |
| CN104857305A (en) * | 2015-05-29 | 2015-08-26 | 海南葫芦娃制药有限公司 | Stomach-recovering pellet as well as preparation method and application thereof |
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2007
- 2007-06-07 CN CNA2007101106111A patent/CN101053631A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101439149B (en) * | 2008-12-19 | 2011-04-20 | 黄远吉 | Chinese medicinal composition for treating gastric ulcer, gastrorrhagia and gastric perforation |
| CN103705734A (en) * | 2013-11-28 | 2014-04-09 | 安徽海神寿春药业有限公司 | Traditional Chinese medicine for treating acute or chronic gastritis |
| CN103705734B (en) * | 2013-11-28 | 2016-03-23 | 安徽海神寿春药业有限公司 | A kind of Chinese medicine for the treatment of chronic gastritis |
| CN103751688A (en) * | 2013-12-30 | 2014-04-30 | 臧萍 | Chinese herbal medicine for treating stomach diseases and preparation method of Chinese herbal medicine |
| CN103751688B (en) * | 2013-12-30 | 2016-04-13 | 臧萍 | A kind of Chinese herbal medicine for the treatment of gastropathy and preparation method thereof |
| CN103920047A (en) * | 2014-04-27 | 2014-07-16 | 王玉娟 | Traditional Chinese medicine preparation for treating gastrorrhagia and preparation method thereof |
| CN104116978A (en) * | 2014-06-13 | 2014-10-29 | 江美珍 | Traditional Chinese medicine for treating stomach duct pain |
| CN104857305A (en) * | 2015-05-29 | 2015-08-26 | 海南葫芦娃制药有限公司 | Stomach-recovering pellet as well as preparation method and application thereof |
| CN104857305B (en) * | 2015-05-29 | 2018-08-17 | 海南葫芦娃药业集团股份有限公司 | A kind of stomach Kang Ling pellets and its preparation method and application |
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