CN1792374A - Traditional Chinese medicine prepns. for treating diabete - Google Patents

Abstract

A Chinese medicine for treating diabetes and decreasing the content of sugar in human body is prepared from 15 Chinese-medicinal materials including peach kernel, chrysanthermum flower, yam, astragalus root, etc.

Description

The lowering blood sugar and preventing thirst Chinese medicine preparation

Technical field

The invention belongs to a kind of pharmaceutical product, particularly a kind of lowering blood sugar and preventing thirst Chinese medicine preparation for the treatment of diabetes.

Technical background

The diabetes that are called as " affluenza ", along with improving constantly of living standards of the people, sickness rate is the trend of rising year by year because it can cause various complication, the serious harm people's is healthy, make us talk sickly skin color and become.Diabetes are searched to the bottom, and are owing to the caused metabolism of hypoinsulinism, endocrine disturbance's property disease, and the cause of disease is not clear mostly, and has genetic predisposition, and its performance characteristic is: blood glucose increases, and contains sugar in the urine.Clinically with " more than three " (polyphagia, polydipsia, polyuria), become thin, fatigue and weak etc. is characterized as main performance, and normal easily concurrency suppurative infection, the ketone acidosis can take place and threat to life when serious in the complication of pulmonary tuberculosis, arteriosclerosis, neuritis and kidney, eye.

At present, the medicine of treatment diabetes can be divided into two kinds in Chinese medicine and Western medicine.Western medicine mainly is by stimulating the islet secretion insulin, to replenish the deficiency of self insulin; Or by partly stoping intestinal that the absorption of sugar is come blood sugar lowering.Common drug has guanidine class, sulfonamides and insuline pro injection, and these Western medicine all are the purposes that reach blood sugar control by interim onset, needs lifelong medication, can produce some side effect simultaneously.Though the Chinese medicine of at present used some has reduced the side effect of Western medicine because compatibility is reasonable inadequately, can only take stopgap measures and can not and basic, need long-term prescription equally, in case drug withdrawal, the state of an illness recurrence that will rebound brings psychic pain and financial burden to the patient.

Summary of the invention

Diabetes belong to " eliminating mass ", " diabetes " category in motherland's medical science, all on the books in the monographs such as TCM Document " interior warp ", " Medical Treasures of the Golden Chamber ", " medical secrets of official ", the successive dynasties physician is divided into three types of upper, middle and lower according to the difference of " more than three " degree with " diabetes ", disappear on thinking at lung, in disappear at stomach, diabetes due to kidney-deficiency at kidney, then think because saying of " it is poly-also that the disease of three types of diabetes is guarded against hot-tempered accumulation of heat " due to deficient, the lung dryness of the stomach heat of stomach-Yin, arranged in " medical science innermost thoughts and feelings " for the mechanism of primary disease.So the present invention overcomes the thinking that existing medicine focuses on blood sugar lowering, adopts methods such as nourishing kidney, lung moistening, lung heat clearing more, focuses on nourishing kidney-YIN, for preventing to nourish the side effect of the greasy stomach of medicine, need activating spleen and strengthening stomach, no matter upper, middle and lower suddenly should be controlled kidney, cloudy gas is gradually filled, and essence and blood is gradually multiple, and then disease must spontaneous recovery.

Preparation of the present invention is made up of following parts by weight of Chinese traditional medicine raw material:

Semen Persicae 10-20, Stigma Maydis 130-190, Cortex Lycii 20-30, Herba Plantaginis 10-20, Flos Chrysanthemi 15-25, Rhizoma Dioscoreae 15-25, Radix Astragali 25-35, Fructus Schisandrae Chinensis 10-20, Radix Trichosanthis 15-25, Radix Rehmanniae 15-25, Fructus Corni 10-20, Herba Taraxaci 15-25, Herba Violae 15-25, Radix Rehmanniae Preparata 15-25, Radix Angelicae Sinensis 10-20.

The preferential preparation of recommending of the present invention is made up of the raw material of Chinese medicine of following weight ratio:

Semen Persicae 15, Stigma Maydis 160, Cortex Lycii 25, Herba Plantaginis 15, Flos Chrysanthemi 20, Rhizoma Dioscoreae 20, the Radix Astragali 30, Fructus Schisandrae Chinensis 15, Radix Trichosanthis 20, the Radix Rehmanniae 20, Fructus Corni 15, Herba Taraxaci 20, Herba Violae 20, Radix Rehmanniae Preparata 20, Radix Angelicae Sinensis 15.

Preparation: with each prescription YAOJING choosing, by the accurate weighing of prescription, dried disinfecting, sterilization, crushing packing get final product.Can be made into powder, watered pill or capsule.

Preparation medicine compatibility of the present invention lexical or textual analysis:

Semen Persicae---removing blood stasis with potent drugs blood is capable, moisturizes laxation;

Stigma Maydis---inducing diuresis to remove edema, blood pressure lowering, blood sugar lowering, the diarrhea of heat type gallbladder disappears;

Cortex Lycii---removing heat from blood moves back steaming, clear purte the white;

Herba Plantaginis---clearing away heat and promoting diuresis is oozed warm antidiarrheal, liver heat removing and eyesight improving, dissipating phlegm and hemastasis;

Flos Chrysanthemi---dispelling wind and heat pathogens, suppressing the hyperactive liver makes eye bright;

Rhizoma Dioscoreae---spleen reinforcing antidiarrheal is supported the lung tonifying YIN, supplementing the kidney to control the nocturnal, YIN nourishing and the production of body fluid promoting;

The Radix Astragali---tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration is supported the skin ulcer granulation promoting, inducing diuresis to remove edema;

Fructus Schisandrae Chinensis---astringing lung-QI and relieving cough, consolidating superficial resistance arresting sweating, arresting seminal emission antidiarrheal, promoting the production of body fluid to quench thirst;

Radix Trichosanthis---heat clearing away spermatogenesis, detumescence and apocenosis;

The Radix Rehmanniae---heat clearing away YIN nourishing, cooling blood for hemostasis, promoting the production of body fluid to quench thirst;

Fructus Corni---liver and kidney tonifying, the arresting seminal emission reducing urination, the controlling nocturnal emission with astringent drugs hemostasis is held back liver and is taken off admittedly;

Herba Taraxaci---heat clearing away toxin expelling, liver heat removing and eyesight improving;

Herba Violae---heat clearing away toxin expelling;

Radix Rehmanniae Preparata---tonifying blood and regulating menstruation, nourishing kidney nourishing YIN (system is used);

Radix Angelicae Sinensis---tonifying blood and regulating menstruation, promoting blood circulation and stopping pain, loosening bowel to relieve constipation.

The present invention all adopts herbal raw material, be main component with inducing diuresis to remove edema medicine Stigma Maydis commonly used among the people in the medicine particularly, between be equipped with heat-clearing and toxic substances removing and liver and kidney tonifying, the Herba Taraxaci of tonifying Qi and lifting yang, Fructus Corni, the Radix Astragali, be aided with spleen reinforcing antidiarrheal simultaneously, the Rhizoma Dioscoreae of the cough-relieving of promoting the production of body fluid, the Radix Rehmanniae, direct blood sugar lowering not only, and help the recovery of pancreatic function.Simultaneously, the present invention also is furnished with the Herba Plantaginis and the Flos Chrysanthemi of liver heat removing and eyesight improving, dispelling wind and heat pathogens, and complication such as the retinopathy that causes for prevent diabetes and cerebrovascular disease has good effect.Proof is evident in efficacy after the many cases patient takes, and has reached the effect for the treatment of both the principal and secondary aspects of a disease, does not rebound after the healing, do not recur, and the curative effect height, short treating period, pharmaceutical preparation is simple, and cost is lower.

The specific embodiment 1:

Choose Semen Persicae 15, Stigma Maydis 160, Cortex Lycii 25, Herba Plantaginis 15, Flos Chrysanthemi 20, Rhizoma Dioscoreae 20, the Radix Astragali 30, Fructus Schisandrae Chinensis 15, Radix Trichosanthis 20, the Radix Rehmanniae 20, Fructus Corni 15, Herba Taraxaci 20, Herba Violae 20, Radix Rehmanniae Preparata 20, Radix Angelicae Sinensis 15; Various compositions mix, and after dried disinfecting, sterilization, the pulverizing, make the watered pill behind the adding supplementary product starch.

Instructions of taking: three times on the one, each 10 grams-20 grams, ante cibum or one hour after meal, clothes were obeyed the 30-60 gram every day altogether.

The specific embodiment 2: take by weighing Semen Persicae 10, Stigma Maydis 190, Cortex Lycii 20, Herba Plantaginis 20, Flos Chrysanthemi 15, Rhizoma Dioscoreae 25, the Radix Astragali 25, Fructus Schisandrae Chinensis 20, Radix Trichosanthis 15, the Radix Rehmanniae 25, Fructus Corni 10, Herba Taraxaci 25, Herba Violae 15, Radix Rehmanniae Preparata 25, Radix Angelicae Sinensis 10, make oral liquid after decocting with water.

The specific embodiment 3: choose Semen Persicae 20, Stigma Maydis 130, Cortex Lycii 30, Herba Plantaginis 10, Flos Chrysanthemi 25, Rhizoma Dioscoreae 15, the Radix Astragali 35, Fructus Schisandrae Chinensis 10, Radix Trichosanthis 25, the Radix Rehmanniae 15, Fructus Corni 20, Herba Taraxaci 15, Herba Violae 25, Radix Rehmanniae Preparata 15, Radix Angelicae Sinensis 20, back 300 mesh sieves excessively of pulverizing are made powder warm water and are taken after mixing it with water.

The final report that the medicine patient of above-mentioned three embodiments takes is as follows:

Hypoglycemic and thirst-relieving Chinese medicine preparation 121 routine clinical reports

One, basic condition

Chinese medicine preparation of the present invention adopts the mode by doctor's outpatient service administration of seeing and treating patients, and has treated 128 routine patients altogether, and return visit data person 121 examples are arranged, and does not see further consultation after all the other 7 routine patients see a doctor once, and the data after yet not having it to take medicine is not so include in the statistics scope.Male's 72 examples among the 121 routine patients of statistics, women 49 people; Patient 71 people more than 60 years old, 45-59 year patient 32 people, 18 people of patient below 45 years old.

Two, diagnosis and curative effect determinate standard

1, diagnostic criteria

Adopt The World Health Organization's standard in 1997: 1, symptoms such as tangible three-many-one-little (polyuria, polyphagia, polydipsia, become thin), blurred vision are arranged, random blood sugar 〉=11.1 mMs/liter.2, fasting glucose 〉=7.0 mMs/liter (be meant early before the meal on an empty stomach, and do not advance the food of energy content at least in 8 hours).3, carry out oral glucose tolerance test, promptly obey 75 the gram glucoses after 2 hours blood glucose 〉=11.1 mMs/liter.See a doctor to have among the patient and satisfy above 3 middle any point persons, require its check once, if conformance with standard still promptly is judged as type 2 diabetes mellitus.

2, efficacy determination

According to above-mentioned standard, it is as follows to have worked out the curative effect determinate standard that uses behind the preparation of the present invention:

Produce effects: clinical symptom more than three obviously alleviates, and blood glucose descends to some extent.

Cure: clinical symptom more than three disappears substantially, and glycemic control does not rebound under the situation of suitably keeping on a diet after the drug withdrawal below the mark.

Invalid: clinical symptom more than three is not seen improvement, and blood glucose is not controlled at below the mark.

Three, Therapeutic Method

The patient who sees a doctor is according to the second standard, all be diagnosed as type 2 diabetes mellitus, the clinical symptoms of three-many-one-little is arranged mostly, and mostly be the trouble diabetes for many years, take other hypoglycemic medicines throughout the year, wherein 85 routine patients after taking other hypoglycemic medicine 2 hours after the meal blood glucose still 13 mMs/liter more than.This type of patient is divided into every day takes preparation of the present invention 60 grams (specifically taking dosage form freely selects according to patient's fancy grade) for three times, all the other patients take 30 every day and restrain.Take general other hypoglycemic medicine of stopping using during the preparation of the present invention (take other hypoglycemic medicines at clothes according to the different situations decrement but post-prandial glycemia is higher than the 15 mM/persons of liter taking medicine within preceding 10 days, but all stop using other medicines after 10 days).Period in a medicine detected next whole day blood glucose (on an empty stomach once, 2 hours three times after the meal) in 15 days.Especially the patient is handed over following doctor's advice:

1, careful food advances the sweet greasy product of fat meat and fine grain less, forbids irritable foods such as pungent, tobacco and wine, suitably increases vegetable protein, reduces starch.2, distantly related thing must be avoided sexual life when stadium and first healing, also will suitably control after being completely recovered.3, guard against trouble anger, Nervous and Mental Factors is particularly close to this sick pass, must guard against sorrow, and anxious state of mind such as indignation, sadness keep pleasant.4, untired, must participate in appropriate exercise or work, but can not be too tired.5, suitable cold warm, whenever climate change will notice that medicated clothing is in good time.

Four, therapeutic outcome statistics

1, took medicine 15 days after test blood glucose statistical table (blood glucose unit: mM/liter)

Testing time	Test value	Patient's number	Percentage ratio
				Before the meal early	4.4---6.4	5	4.1
6.4---7.8	41	33.9
			≥7.8		75	62.0
After the meal early	4.4---7.8	7					5.7
			7.8---11	69	57.0
	≥11	45				37.3
			After the lunch	4.4---7.8	3		2.5
7.8---11	45	37.2
				≥11	73	60.3
After the dinner	4.4---7.8	4					3.3
			7.8---11	49	40.5
	≥11	68				56.2

2, took medicine 30 days after test blood glucose statistical table (blood glucose unit: mM/liter)

Testing time	Test value	Patient's number	Percentage ratio
				Before the meal early	4.4---6.4	9	7.4
6.4---7.8	56	46.3
			≥7.8		56	46.3
After the meal early	4.4---7.8	9					7.4
			7.8---11	73	60.3
	≥11	39				32.3
			After the lunch	4.4---7.8	5		4.1
7.8---11	54	44.6
				≥11	62	51.3
After the dinner	4.4---7.8	7					5.9
			7.8---11	61	50.4
	≥11	53				43.7

3, took medicine 45 days after test blood glucose statistical table (blood glucose unit: mM/liter)

Testing time	Test value	Patient's number	Percentage ratio
				Before the meal early	4.4---6.4	15	12.4
6.4---7.8	80	66.1
			≥7.8		26	21.5
After the meal early	4.4---7.8	14					11.6
			7.8---11	83	68.6
	≥11	24				19.8
			After the lunch	4.4---7.8	11		9.1
7.8---11	89	73.6
				≥11	21	17.3
After the dinner	4.4---7.8	19					15.7
			7.8---11	87	71.9
	≥11	15				12.4

4, took medicine 60 days after test blood glucose statistical table (blood glucose unit: mM/liter)

Testing time	Test value	Patient's number	Percentage ratio
				Before the meal early	4.4---6.4	23	19.0
6.4---7.8	91	75.2
			≥7.8		7	5.8
After the meal early	4.4---7.8	25					20.7
			7.8---11	91	75.2
	≥11	5				4.1
			After the lunch	4.4---7.8	19		15.7
7.8---11	94	77.7
				≥11	8	6.6
After the dinner	4.4---7.8	28					23.1
			7.8---11	89	73.6
	≥11	4				3.3

In above table, blood glucose value 4.4---6.4 is the glycemic control desirable level of generally acknowledging before the meal, and 6.4---7.8 is a mean level, is poor greater than 7.8, and blood glucose value 4.4---7.8 was desirable in 2 hours after the meal, and 7.8---11 is general, is poor greater than 11.As can be seen, Most patients blood glucose after taking 45 days is under control, and most patient's blood glucose have been controlled at below the markly after 60 days, and decidable is a produce effects.The obvious effective rate average out to 95.05% that this detects, can not be controlled at substandard is 4.95%.For the patient of produce effects, follow up a case by regular visits in 1 year four times after the drug withdrawal, under the appropriate exercise and the situation of keeping on a diet, do not take the medicine of any treatment diabetes, all reflection does not have the diabetes clinical symptoms, and glycemic control is at ideal or mean level.So aforementioned produce effects patient all can be judged as healing.

Five, model case

Woman Yao 62 years old, suffered from diabetes more than 20 year.Take fasting glucose 11.9 mMs before the medicine of the present invention/liter, (following blood glucose unit is identical, omits) glucose in urine is (++ ++) after the meal, on an empty stomach ±, the 7 days glucoses in urine (-) after the meal of taking medicine, fasting glucose 8.5 in the time of 15 days, 2 hours 10.8 after the meal.Transference cure more than three after 60 days, empty stomach glucose in urine (-) or (±), blood glucose 5.1 is not seen recurrence after the post-prandial glycemia 7.5. drug withdrawal.

Liang Nan, 44 years old, take fasting glucose 9.9 mMs before the medicine of the present invention/liter, glucose in urine is (++ ++) after the meal, on an empty stomach ±.Transference cure more than three after taking medicine 40 days, empty stomach glucose in urine (-), blood glucose 5.1 is not seen recurrence after post-prandial glycemia 6.7 drug withdrawals.

Huang Nan 37 years old, takes preceding fasting glucose 15 mMs of medicine of the present invention/liter (following blood glucose unit is identical, omits), glucose in urine is (++ ++) after the meal, on an empty stomach ±, transference cure more than three after taking medicine 60 days, empty stomach glucose in urine (-) or (±), blood glucose 5.1 is not seen recurrence after post-prandial glycemia 6.7 drug withdrawals.

Woman Liu, 29 years old, take fasting glucose 13.9 mMs before the medicine of the present invention/liter, (following blood glucose unit is identical, omits) glucose in urine is (++ ++) after the meal, on an empty stomach ±, the fasting glucose 8.5 15 days time of taking medicine, 2 hours 10.8 after the meal.Transference cure more than three after 30 days, empty stomach glucose in urine (-) or (±), blood glucose 5.1, post-prandial glycemia 5.8 is not seen recurrence after the drug withdrawal.

Gu Nan, 42 years old, take fasting glucose 9.3-16.4 mM before the medicine of the present invention/liter, (following blood glucose unit is identical, omits) glucose in urine is (++ ++) after the meal, on an empty stomach ±, the 45 days glucoses in urine (-) after the meal of taking medicine, fasting glucose 8.5,2 hours 10.8 after the meal.Transference cure more than three after 60 days.Because this patient is engaged in sale, dietetic life is irregular, and the post-prandial glycemia bounce-back reduces to 5.8 to 13.6 again when sporadicly taking medicine of the present invention as follows after the drug withdrawal.

Claims (2)

1, a kind of lowering blood sugar and preventing thirst Chinese medicine preparation is characterized in that being made by following parts by weight of Chinese traditional medicine raw material: Semen Persicae 10-20, Stigma Maydis 130-190, Cortex Lycii 20-30, Herba Plantaginis 10-20, Flos Chrysanthemi 15-25, Rhizoma Dioscoreae 15-25, Radix Astragali 25-35, Fructus Schisandrae Chinensis 10-20, Radix Trichosanthis 15-25, Radix Rehmanniae 15-25, Fructus Corni 10-20, Herba Taraxaci 15-25, Herba Violae 15-25, Radix Rehmanniae Preparata 15-25, Radix Angelicae Sinensis 10-20.

2, lowering blood sugar and preventing thirst Chinese medicine preparation according to claim 1 is characterized in that being made by the raw material of Chinese medicine of following weight ratio:

Semen Persicae 15, Stigma Maydis 160, Cortex Lycii 25, Herba Plantaginis 15, Flos Chrysanthemi 20, Rhizoma Dioscoreae 20, the Radix Astragali 30, Fructus Schisandrae Chinensis 15, Radix Trichosanthis 20, the Radix Rehmanniae 20, Fructus Corni 15, Herba Taraxaci 20, Herba Violae 20, Radix Rehmanniae Preparata 20, Radix Angelicae Sinensis 15.